Karen Ocorr, PhD - Publications

Sanford-Burnham Medical Research Institute, USA 

67 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Achal M, Trujillo AS, Melkani GC, Farman GP, Ocorr K, Viswanathan MC, Kaushik G, Newhard CS, Glasheen BM, Melkani A, Suggs JA, Moore JR, Swank DM, Bodmer R, Cammarato A, et al. A restrictive cardiomyopathy mutation in an invariant proline at the myosin head/rod junction enhances head flexibility and function, yielding muscle defects in Drosophila. Journal of Molecular Biology. PMID 27107639 DOI: 10.1016/j.jmb.2016.04.021  1
2015 Zarndt R, Piloto S, Powell FL, Haddad GG, Bodmer R, Ocorr K. Cardiac responses to hypoxia and reoxygenation in Drosophila. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. ajpregu.00164.2015. PMID 26377557 DOI: 10.1152/ajpregu.00164.2015  1
2015 Ivy JR, Drechsler M, Catterson JH, Bodmer R, Ocorr K, Paululat A, Hartley PS. Klf15 Is Critical for the Development and Differentiation of Drosophila Nephrocytes. Plos One. 10: e0134620. PMID 26301956 DOI: 10.1371/journal.pone.0134620  1
2015 Martínez-Morentin L, Martínez L, Piloto S, Yang H, Schon EA, Garesse R, Bodmer R, Ocorr K, Cervera M, Arredondo JJ. Cardiac deficiency of single cytochrome oxidase assembly factor scox induces p53-dependent apoptosis in a Drosophila cardiomyopathy model. Human Molecular Genetics. 24: 3608-22. PMID 25792727 DOI: 10.1093/hmg/ddv106  1
2015 Diop SB, Bisharat-Kernizan J, Birse RT, Oldham S, Ocorr K, Bodmer R. PGC-1/Spargel Counteracts High-Fat-Diet-Induced Obesity and Cardiac Lipotoxicity Downstream of TOR and Brummer ATGL Lipase. Cell Reports. PMID 25753422 DOI: 10.1016/j.celrep.2015.02.022  1
2015 Cammarato A, Ocorr S, Ocorr K. Enhanced assessment of contractile dynamics in Drosophila hearts. Biotechniques. 58: 77-80. PMID 25652030 DOI: 10.2144/000114255  1
2015 Smith KA, Voiriot G, Tang H, Fraidenburg DR, Song S, Yamamura H, Yamamura A, Guo Q, Wan J, Pohl NM, Tauseef M, Bodmer R, Ocorr K, Thistlethwaite PA, Haddad GG, et al. Notch Activation of Ca(2+) Signaling Mediates Hypoxic Pulmonary Vasoconstriction and Pulmonary Hypertension. American Journal of Respiratory Cell and Molecular Biology. PMID 25569851 DOI: 10.1165/rcmb.2014-0235OC  1
2014 Ocorr K, Vogler G, Bodmer R. Methods to assess Drosophila heart development, function and aging. Methods (San Diego, Calif.). 68: 265-72. PMID 24727147 DOI: 10.1016/j.ymeth.2014.03.031  1
2014 Lim HY, Wang W, Chen J, Ocorr K, Bodmer R. ROS regulate cardiac function via a distinct paracrine mechanism. Cell Reports. 7: 35-44. PMID 24656823 DOI: 10.1016/j.celrep.2014.02.029  1
2014 Nishimura M, Kumsta C, Kaushik G, Diop SB, Ding Y, Bisharat-Kernizan J, Catan H, Cammarato A, Ross RS, Engler AJ, Bodmer R, Hansen M, Ocorr K. A dual role for integrin-linked kinase and β1-integrin in modulating cardiac aging. Aging Cell. 13: 431-40. PMID 24400780 DOI: 10.1111/acel.12193  1
2014 Tang M, Yuan W, Bodmer R, Wu X, Ocorr K. The role of pygopus in the differentiation of intracardiac valves in Drosophila. Genesis (New York, N.Y. : 2000). 52: 19-28. PMID 24265259 DOI: 10.1002/dvg.22724  1
2013 Melkani GC, Trujillo AS, Ramos R, Bodmer R, Bernstein SI, Ocorr K. Huntington's disease induced cardiac amyloidosis is reversed by modulating protein folding and oxidative stress pathways in the Drosophila heart. Plos Genetics. 9: e1004024. PMID 24367279 DOI: 10.1371/journal.pgen.1004024  1
2013 Tang M, Yuan W, Fan X, Liu M, Bodmer R, Ocorr K, Wu X. Pygopus maintains heart function in aging Drosophila independently of canonical Wnt signaling. Circulation. Cardiovascular Genetics. 6: 472-80. PMID 24046329 DOI: 10.1161/CIRCGENETICS.113.000253  1
2013 Wang X, Liao P, Fan X, Wan Y, Wang Y, Li Y, Jiang Z, Ye X, Mo X, Ocorr K, Deng Y, Wu X, Yuan W. CXXC5 Associates with Smads to Mediate TNF-α Induced Apoptosis. Current Molecular Medicine. 13: 1385-96. PMID 23906331 DOI: 10.2174/15665240113139990069  1
2013 Harpaz N, Ordan E, Ocorr K, Bodmer R, Volk T. Multiplexin promotes heart but not aorta morphogenesis by polarized enhancement of slit/robo activity at the heart lumen. Plos Genetics. 9: e1003597. PMID 23825967 DOI: 10.1371/journal.pgen.1003597  1
2013 Zhang R, Han P, Yang H, Ouyang K, Lee D, Lin YF, Ocorr K, Kang G, Chen J, Stainier DY, Yelon D, Chi NC. In vivo cardiac reprogramming contributes to zebrafish heart regeneration. Nature. 498: 497-501. PMID 23783515 DOI: 10.1038/nature12322  1
2013 Zhang Z, Hsieh B, Poe A, Anderson J, Ocorr K, Gibson G, Bodmer R. Complex genetic architecture of cardiac disease in a wild type inbred strain of Drosophila melanogaster. Plos One. 8: e62909. PMID 23638165 DOI: 10.1371/journal.pone.0062909  1
2013 Na J, Musselman LP, Pendse J, Baranski TJ, Bodmer R, Ocorr K, Cagan R. A Drosophila model of high sugar diet-induced cardiomyopathy. Plos Genetics. 9: e1003175. PMID 23326243 DOI: 10.1371/journal.pgen.1003175  1
2012 Spindler SR, Li R, Dhahbi JM, Yamakawa A, Mote P, Bodmer R, Ocorr K, Williams RT, Wang Y, Ablao KP. Statin treatment increases lifespan and improves cardiac health in Drosophila by decreasing specific protein prenylation. Plos One. 7: e39581. PMID 22737247 DOI: 10.1371/journal.pone.0039581  1
2012 Hong TT, Smyth JW, Chu KY, Vogan JM, Fong TS, Jensen BC, Fang K, Halushka MK, Russell SD, Colecraft H, Hoopes CW, Ocorr K, Chi NC, Shaw RM. BIN1 is reduced and Cav1.2 trafficking is impaired in human failing cardiomyocytes. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 9: 812-20. PMID 22138472 DOI: 10.1016/j.hrthm.2011.11.055  1
2011 Grossman TR, Gamliel A, Wessells RJ, Taghli-Lamallem O, Jepsen K, Ocorr K, Korenberg JR, Peterson KL, Rosenfeld MG, Bodmer R, Bier E. Over-expression of DSCAM and COL6A2 cooperatively generates congenital heart defects. Plos Genetics. 7: e1002344. PMID 22072978 DOI: 10.1371/journal.pgen.1002344  1
2011 Melkani GC, Bodmer R, Ocorr K, Bernstein SI. The UNC-45 chaperone is critical for establishing myosin-based myofibrillar organization and cardiac contractility in the Drosophila heart model. Plos One. 6: e22579. PMID 21799905 DOI: 10.1371/journal.pone.0022579  1
2011 Eleftherianos I, Won S, Chtarbanova S, Squiban B, Ocorr K, Bodmer R, Beutler B, Hoffmann JA, Imler JL. ATP-sensitive potassium channel (K(ATP))-dependent regulation of cardiotropic viral infections. Proceedings of the National Academy of Sciences of the United States of America. 108: 12024-9. PMID 21719711 DOI: 10.1073/pnas.1108926108  1
2011 Qian L, Wythe JD, Liu J, Cartry J, Vogler G, Mohapatra B, Otway RT, Huang Y, King IN, Maillet M, Zheng Y, Crawley T, Taghli-Lamallem O, Semsarian C, Dunwoodie S, ... ... Ocorr K, et al. Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species. The Journal of Cell Biology. 193: 1181-96. PMID 21690310 DOI: 10.1083/jcb.201006114  1
2011 Fan X, Yang Q, Wang Y, Zhang Y, Wang J, Yuan J, Li Y, Wang Y, Deng Y, Yuan W, Mo X, Wan Y, Ocorr K, Yang X, Wu X. Cloning and characterization of the cardiac-specific Lrrc10 promoter. Bmb Reports. 44: 123-8. PMID 21345312 DOI: 10.5483/BMBRep.2011.44.2.123  1
2011 Lim HY, Wang W, Wessells RJ, Ocorr K, Bodmer R. Phospholipid homeostasis regulates lipid metabolism and cardiac function through SREBP signaling in Drosophila. Genes & Development. 25: 189-200. PMID 21245170 DOI: 10.1101/gad.1992411  1
2011 Nishimura M, Ocorr K, Bodmer R, Cartry J. Drosophila as a model to study cardiac aging. Experimental Gerontology. 46: 326-30. PMID 21130861 DOI: 10.1016/j.exger.2010.11.035  1
2011 Huang W, Deng Y, Dong W, Yuan W, Wan Y, Mo X, Li Y, Wang Z, Wang Y, Ocorr K, Zhang B, Lin S, Wu X. The effect of excess expression of GFP in a novel heart-specific green fluorescence zebrafish regulated by nppa enhancer at early embryonic development. Molecular Biology Reports. 38: 793-9. PMID 20383585 DOI: 10.1007/s11033-010-0168-1  1
2010 Birse RT, Choi J, Reardon K, Rodriguez J, Graham S, Diop S, Ocorr K, Bodmer R, Oldham S. High-fat-diet-induced obesity and heart dysfunction are regulated by the TOR pathway in Drosophila. Cell Metabolism. 12: 533-44. PMID 21035763 DOI: 10.1016/j.cmet.2010.09.014  1
2010 Luo N, Li G, Li Y, Fan X, Wang Y, Ye X, Mo X, Zhou J, Yuan W, Tan M, Xie H, Ocorr K, Bodmer R, Deng Y, Wu X. SAMD4B, a novel SAM-containing protein, inhibits AP-1-, p53- and p21-mediated transcriptional activity. Bmb Reports. 43: 355-61. PMID 20510020  1
2010 Neely GG, Kuba K, Cammarato A, Isobe K, Amann S, Zhang L, Murata M, Elmén L, Gupta V, Arora S, Sarangi R, Dan D, Fujisawa S, Usami T, Xia CP, ... ... Ocorr K, et al. A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Cell. 141: 142-53. PMID 20371351 DOI: 10.1016/j.cell.2010.02.023  1
2010 Lee JH, Budanov AV, Park EJ, Birse R, Kim TE, Perkins GA, Ocorr K, Ellisman MH, Bodmer R, Bier E, Karin M. Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. Science (New York, N.Y.). 327: 1223-8. PMID 20203043 DOI: 10.1126/science.1182228  1
2010 Hu J, Yuan W, Tang M, Wang Y, Fan X, Mo X, Li Y, Ying Z, Wan Y, Ocorr K, Bodmer R, Deng Y, Wu X. KBTBD7, a novel human BTB-kelch protein, activates transcriptional activities of SRE and AP-1. Bmb Reports. 43: 17-22. PMID 20132730  1
2009 Alayari NN, Vogler G, Taghli-Lamallem O, Ocorr K, Bodmer R, Cammarato A. Fluorescent labeling of Drosophila heart structures. Journal of Visualized Experiments : Jove. PMID 19826399 DOI: 10.3791/1423  1
2009 Vogler G, Ocorr K. Visualizing the beating heart in Drosophila. Journal of Visualized Experiments : Jove. PMID 19786947 DOI: 10.3791/1425  1
2009 Ocorr K, Fink M, Cammarato A, Bernstein S, Bodmer R. Semi-automated Optical Heartbeat Analysis of small hearts. Journal of Visualized Experiments : Jove. PMID 19759521 DOI: 10.3791/1435  1
2009 Akasaka T, Ocorr K. Drug discovery through functional screening in the Drosophila heart. Methods in Molecular Biology (Clifton, N.J.). 577: 235-49. PMID 19718521 DOI: 10.1007/978-1-60761-232-2_18  1
2009 Shahrestani P, Leung HT, Le PK, Pak WL, Tse S, Ocorr K, Huang T. Heterozygous mutation of Drosophila Opa1 causes the development of multiple organ abnormalities in an age-dependent and organ-specific manner. Plos One. 4: e6867. PMID 19718456 DOI: 10.1371/journal.pone.0006867  1
2009 Wessells R, Fitzgerald E, Piazza N, Ocorr K, Morley S, Davies C, Lim HY, Elmén L, Hayes M, Oldham S, Bodmer R. d4eBP acts downstream of both dTOR and dFoxo to modulate cardiac functional aging in Drosophila. Aging Cell. 8: 542-52. PMID 19594484 DOI: 10.1111/j.1474-9726.2009.00504.x  1
2009 Fink M, Callol-Massot C, Chu A, Ruiz-Lozano P, Izpisua Belmonte JC, Giles W, Bodmer R, Ocorr K. A new method for detection and quantification of heartbeat parameters in Drosophila, zebrafish, and embryonic mouse hearts. Biotechniques. 46: 101-13. PMID 19317655 DOI: 10.2144/000113078  1
2009 Buechling T, Akasaka T, Vogler G, Ruiz-Lozano P, Ocorr K, Bodmer R. Non-autonomous modulation of heart rhythm, contractility and morphology in adult fruit flies. Developmental Biology. 328: 483-92. PMID 19233157 DOI: 10.1016/j.ydbio.2009.02.013  1
2009 Qian L, Mohapatra B, Akasaka T, Liu J, Ocorr K, Towbin JA, Bodmer R. Transcription factor neuromancer/TBX20 is required for cardiac function in Drosophila with implications for human heart disease (Proceedings of the National Academy of Sciences of the United States of America (2008) 105, 50 (19833-19838) DOI: 10.1073/pnas.0808705105) Proceedings of the National Academy of Sciences of the United States of America. 106: 12561. DOI: 10.1073/pnas.0907125106  1
2009 Buechling T, Akasaka T, Vogler G, Ruiz-Lozano P, Ocorr K, Bodmer R. Corrigendum to "Non-autonomous modulation of heart rhythm, contractility and morphology in adult fruit flies" [Dev. Biol. 328 (2009) 483-492] (DOI:10.1016/j.ydbio.2009.02.013) Developmental Biology. 334: 547. DOI: 10.1016/j.ydbio.2009.08.013  1
2008 Qian L, Mohapatra B, Akasaka T, Liu J, Ocorr K, Towbin JA, Bodmer R. Transcription factor neuromancer/TBX20 is required for cardiac function in Drosophila with implications for human heart disease. Proceedings of the National Academy of Sciences of the United States of America. 105: 19833-8. PMID 19074289 DOI: 10.1073/pnas.0808705105  1
2008 Yu W, Li Y, Zhou X, Deng Y, Wang Z, Yuan W, Li D, Zhu C, Zhao X, Mo X, Huang W, Luo N, Yan Y, Ocorr K, Bodmer R, et al. A novel human BTB-kelch protein KLHL31, strongly expressed in muscle and heart, inhibits transcriptional activities of TRE and SRE. Molecules and Cells. 26: 443-53. PMID 18719355  1
2008 Taghli-Lamallem O, Akasaka T, Hogg G, Nudel U, Yaffe D, Chamberlain JS, Ocorr K, Bodmer R. Dystrophin deficiency in Drosophila reduces lifespan and causes a dilated cardiomyopathy phenotype. Aging Cell. 7: 237-49. PMID 18221418 DOI: 10.1111/j.1474-9726.2008.00367.x  1
2008 Li Y, Yang D, Bai Y, Mo X, Huang W, Yuan W, Yin Z, Deng Y, Murashko O, Wang Y, Fan X, Zhu C, Ocorr K, Bodmer R, Wu X. ZNF418, a novel human KRAB/C2H2 zinc finger protein, suppresses MAPK signaling pathway. Molecular and Cellular Biochemistry. 310: 141-51. PMID 18084723 DOI: 10.1007/s11010-007-9674-4  1
2008 Mery A, Taghli-Lamallem O, Clark KA, Beckerle MC, Wu X, Ocorr K, Bodmer R. The Drosophila muscle LIM protein, Mlp84B, is essential for cardiac function. The Journal of Experimental Biology. 211: 15-23. PMID 18083727 DOI: 10.1242/jeb.012435  1
2008 Shaw P, Ocorr K, Bodmer R, Oldham S. Drosophila aging 2006/2007. Experimental Gerontology. 43: 5-10. PMID 18061385 DOI: 10.1016/j.exger.2007.10.008  1
2008 Cammarato A, Dambacher CM, Knowles AF, Kronert WA, Bodmer R, Ocorr K, Bernstein SI. Myosin transducer mutations differentially affect motor function, myofibril structure, and the performance of skeletal and cardiac muscles. Molecular Biology of the Cell. 19: 553-62. PMID 18045988 DOI: 10.1091/mbc.E07-09-0890  1
2007 Li J, Wang Y, Fan X, Mo X, Wang Z, Li Y, Yin Z, Deng Y, Luo N, Zhu C, Liu M, Ma Q, Ocorr K, Yuan W, Wu X. ZNF307, a novel zinc finger gene suppresses p53 and p21 pathway. Biochemical and Biophysical Research Communications. 363: 895-900. PMID 17910948 DOI: 10.1016/j.bbrc.2007.08.180  1
2007 Ocorr KA, Crawley T, Gibson G, Bodmer R. Genetic variation for cardiac dysfunction in Drosophila. Plos One. 2: e601. PMID 17622346 DOI: 10.1371/journal.pone.0000601  1
2007 Ocorr K, Perrin L, Lim HY, Qian L, Wu X, Bodmer R. Genetic control of heart function and aging in Drosophila. Trends in Cardiovascular Medicine. 17: 177-82. PMID 17574126 DOI: 10.1016/j.tcm.2007.04.001  1
2007 Ocorr K, Reeves NL, Wessells RJ, Fink M, Chen HS, Akasaka T, Yasuda S, Metzger JM, Giles W, Posakony JW, Bodmer R. KCNQ potassium channel mutations cause cardiac arrhythmias in Drosophila that mimic the effects of aging. Proceedings of the National Academy of Sciences of the United States of America. 104: 3943-8. PMID 17360457 DOI: 10.1073/pnas.0609278104  1
2007 Ocorr K, Akasaka T, Bodmer R. Age-related cardiac disease model of Drosophila. Mechanisms of Ageing and Development. 128: 112-6. PMID 17125816 DOI: 10.1016/j.mad.2006.11.023  1
2006 Akasaka T, Klinedinst S, Ocorr K, Bustamante EL, Kim SK, Bodmer R. The ATP-sensitive potassium (KATP) channel-encoded dSUR gene is required for Drosophila heart function and is regulated by tinman. Proceedings of the National Academy of Sciences of the United States of America. 103: 11999-2004. PMID 16882722 DOI: 10.1073/pnas.0603098103  1
2003 Ocorr K, Osgood MP. Self or help? A comparison of a personalized system of instruction biochemistry class to a standard lecture-based biochemistry class Biochemistry and Molecular Biology Education. 31: 308-312. DOI: 10.1002/bmb.2003.494031050259  1
2000 Venkatesh TV, Park M, Ocorr K, Nemaceck J, Golden K, Wemple M, Bodmer R. Cardiac enhancer activity of the homeobox gene tinman depends on CREB consensus binding sites in Drosophila. Genesis (New York, N.Y. : 2000). 26: 55-66. PMID 10660673 DOI: 10.1002/(SICI)1526-968X(200001)26:1<55::AID-GENE8>3.0.CO;2-A  1
1997 Bodmer R, Golden KL, Lockwood WK, Ocorr KA, Park M, Su MT, Venkatesh TV. Heart Development in Drosophila Advances in Developmental Biology (1992). 5: 201-236. DOI: 10.1016/S1566-3116(08)60038-9  1
1991 Lemos JR, Lee CJ, Ocorr KA, Dayanithi G, Nordmann JJ. Possible role for neurosecretory granule channel that resembles gap junctions. Annals of the New York Academy of Sciences. 635: 480-2. PMID 1720606  1
1991 Ocorr KA, Schulman H. Activation of multifunctional Ca2+/calmodulin-dependent kinase in intact hippocampal slices. Neuron. 6: 907-14. PMID 1647175 DOI: 10.1016/0896-6273(91)90231-N  1
1989 Lemos JR, Ocorr KA, Nordmann JJ. Possible role for ionic channels in neurosecretory granules of the rat neurohypophysis. Society of General Physiologists Series. 44: 333-47. PMID 2476857  1
1986 Ocorr KA, Byrne JH. Evidence for separate receptors that mediate parallel effects of serotonin and small cardioactive peptideB (SCPB) on adenylate cyclase in Aplysia californica. Neuroscience Letters. 70: 283-8. PMID 3095711 DOI: 10.1016/0304-3940(86)90478-7  1
1986 Ocorr KA, Tabata M, Byrne JH. Stimuli that produce sensitization lead to elevation of cyclic AMP levels in tail sensory neurons of Aplysia. Brain Research. 371: 190-2. PMID 2871895 DOI: 10.1016/0006-8993(86)90828-0  1
1985 Ocorr KA, Byrne JH. Membrane responses and changes in cAMP levels in Aplysia sensory neurons produced by serotonin, tryptamine, FMRFamide and small cardioactive peptideB (SCPB). Neuroscience Letters. 55: 113-8. PMID 2987761 DOI: 10.1016/0304-3940(85)90004-7  1
1985 Ocorr KA, Walters ET, Byrne JH. Associative conditioning analog selectively increases cAMP levels of tail sensory neurons in Aplysia. Proceedings of the National Academy of Sciences of the United States of America. 82: 2548-52. PMID 2986121  1
1983 Ocorr KA, Berlind A. The identification and localization of a catecholamine in the motor neurons of the lobster cardiac ganglion. Journal of Neurobiology. 14: 51-9. PMID 6298362 DOI: 10.1002/neu.480140107  1
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