Hui-Kuan Lin, Ph.D. - Publications

2002 University of Rochester, Rochester, NY 
Pathology, Oncology, Molecular Biology

82 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Rezaeian AH, Li CF, Wu CY, Zhang X, Delacerda J, You MJ, Han F, Cai Z, Jeong YS, Jin G, Phan L, Chou PC, Lee MH, Hung MC, Sarbassov D, ... Lin HK, et al. Author Correction: A hypoxia-responsive TRAF6-ATM-H2AX signalling axis promotes HIF1α activation, tumorigenesis and metastasis. Nature Cell Biology. PMID 32504031 DOI: 10.1038/s41556-020-0538-4  0.44
2020 Liu C, Ma Z, Cai Z, Zhang F, Liu C, Chen T, Peng D, Xu X, Lin HK. Identification of primordial germ cell-like cells as liver metastasis initiating cells in mouse tumour models. Cell Discovery. 6: 15. PMID 32218989 DOI: 10.1038/s41421-020-0145-3  0.32
2020 Lei J, Song GT, He LJ, Luo YF, Tang DY, Lin HK, Frett B, Li HY, Chen ZZ, Xu ZG. Correction: One-pot construction of functionalized aziridines and maleimides via a novel pseudo-Knoevenagel cascade reaction. Chemical Communications (Cambridge, England). PMID 32031562 DOI: 10.1039/d0cc90063j  0.32
2020 Cai Z, Moten A, Peng D, Hsu CC, Pan BS, Kumar Manne R, Li HY, Lin HK. The Skp2 Pathway: A Critical Target for Cancer Therapy. Seminars in Cancer Biology. PMID 32014608 DOI: 10.1016/j.semcancer.2020.01.013  0.48
2020 Lei J, Song GT, He LJ, Luo YF, Tang DY, Lin HK, Frett B, Li HY, Chen ZZ, Xu ZG. One-pot construction of functionalized aziridines and maleimides via a novel pseudo-Knoevenagel cascade reaction. Chemical Communications (Cambridge, England). PMID 31971170 DOI: 10.1039/c9cc08220d  0.32
2019 Li Y, Huang JH, Wang JL, Song GT, Tang D, Yao F, Lin HK, Yan W, Li HY, Xu ZG, Chen ZZ. Diversity-Oriented Synthesis of Imidazo-Dipyridines with Anticancer Activity via Groebke-Blackburn-Bienaymé and TBAB-Mediated Cascade Reaction in One Pot. The Journal of Organic Chemistry. PMID 31357859 DOI: 10.1021/acs.joc.9b01385  0.32
2019 Zhang W, Wang G, Xu ZG, Tu H, Hu F, Dai J, Chang Y, Chen Y, Lu Y, Zeng H, Cai Z, Han F, Xu C, Jin G, Sun L, ... ... Lin HK, et al. Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS. Cell. PMID 31155231 DOI: 10.1016/j.cell.2019.05.003  0.44
2019 Wang G, Long J, Gao Y, Zhang W, Han F, Xu C, Sun L, Yang SC, Lan J, Hou Z, Cai Z, Jin G, Hsu CC, Wang YH, Hu J, ... ... Lin HK, et al. SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis. Nature Cell Biology. PMID 30692626 DOI: 10.1038/s41556-018-0266-1  0.48
2019 Zhu GF, Xu YW, Li J, Niu HL, Ma WX, Xu J, Zhou PR, Liu X, Ye DL, Liu XR, Yan T, Zhai WK, Xu ZJ, Liu C, Wang L, ... ... Lin HK, et al. Mir20a/106a-WTX axis regulates RhoGDIa/CDC42 signaling and colon cancer progression. Nature Communications. 10: 112. PMID 30631060 DOI: 10.1038/s41467-018-07998-x  0.6
2018 Han F, Li CF, Cai Z, Zhang X, Jin G, Zhang WN, Xu C, Wang CY, Morrow J, Zhang S, Xu D, Wang G, Lin HK. The critical role of AMPK in driving Akt activation under stress, tumorigenesis and drug resistance. Nature Communications. 9: 4728. PMID 30413706 DOI: 10.1038/s41467-018-07188-9  0.44
2018 Liu C, Cai Z, Jin G, Peng D, Pan BS, Zhang X, Han F, Xu X, Lin HK. Abnormal gametogenesis induced by p53 deficiency promotes tumor progression and drug resistance. Cell Discovery. 4: 54. PMID 30302273 DOI: 10.1038/s41421-018-0054-x  0.44
2018 He LJ, Yang DL, Li SQ, Zhang YJ, Tang Y, Lei J, Frett B, Lin HK, Li HY, Chen ZZ, Xu ZG. Facile construction of fused benzimidazole-isoquinolinones that induce cell-cycle arrest and apoptosis in colorectal cancer cells. Bioorganic & Medicinal Chemistry. PMID 29921474 DOI: 10.1016/j.bmc.2018.06.010  0.32
2018 Xu ZG, Li SQ, Meng JP, Tang DY, He LJ, Lei J, Lin HK, Li HY, Chen ZZ. Functionalized Spiroindolines with Anticancer Activity through a Metal-Free Post-Ugi Diastereoselective One-Pot Cascade Reaction. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 29676029 DOI: 10.1002/chem.201801081  0.32
2018 Jin G, Xu C, Zhang X, Long J, Rezaeian AH, Liu C, Furth ME, Kridel S, Pasche B, Bian XW, Lin HK. Atad3a suppresses Pink1-dependent mitophagy to maintain homeostasis of hematopoietic progenitor cells. Nature Immunology. 19: 29-40. PMID 29242539 DOI: 10.1038/s41590-017-0002-1  0.44
2017 Wu CY, Cherng JY, Yang YH, Lin CL, Kuan FC, Lin YY, Lin YS, Shu LH, Cheng YC, Liu HT, Lu MC, Lung J, Chen PC, Lin HK, Lee KD, et al. Danshen improves survival of patients with advanced lung cancer and targeting the relationship between macrophages and lung cancer cells. Oncotarget. 8: 90925-90947. PMID 29207614 DOI: 10.18632/oncotarget.18767  0.36
2017 Zhang X, Li B, Rezaeian AH, Xu X, Chou PC, Jin G, Han F, Pan BS, Wang CY, Long J, Zhang A, Huang CY, Tsai FJ, Tsai CH, Logothetis C, ... Lin HK, et al. H3 ubiquitination by NEDD4 regulates H3 acetylation and tumorigenesis. Nature Communications. 8: 14799. PMID 28300060 DOI: 10.1038/ncomms14799  0.44
2017 Rezaeian AH, Wang YH, Lin HK. DNA damage players are linked to HIF-1α/hypoxia signaling. Cell Cycle (Georgetown, Tex.). 0. PMID 28282267 DOI: 10.1080/15384101.2017.1302208  0.4
2016 Rezaeian AH, Li CF, Wu CY, Zhang X, Delacerda J, You MJ, Han F, Cai Z, Jeong YS, Jin G, Phan L, Chou PC, Lee MH, Hung MC, Sarbassov D, ... Lin HK, et al. A hypoxia-responsive TRAF6-ATM-H2AX signalling axis promotes HIF1α activation, tumorigenesis and metastasis. Nature Cell Biology. PMID 27918549 DOI: 10.1038/ncb3445  0.44
2016 Zhang X, Li CF, Zhang L, Wu CY, Han L, Jin G, Rezaeian AH, Han F, Liu C, Xu C, Xu X, Huang CY, Tsai FJ, Tsai CH, Watabe K, ... Lin HK, et al. TRAF6 Restricts p53 Mitochondrial Translocation, Apoptosis, and Tumor Suppression. Molecular Cell. PMID 27818144 DOI: 10.1016/j.molcel.2016.10.002  0.44
2016 Liu X, Xiao ZD, Han L, Zhang J, Lee SW, Wang W, Lee H, Zhuang L, Chen J, Lin HK, Wang J, Liang H, Gan B. LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress. Nature Cell Biology. PMID 26999735 DOI: 10.1038/ncb3328  0.44
2016 Li N, Dhar SS, Chen TY, Kan PY, Wei Y, Kim JH, Chan CH, Lin HK, Hung MC, Lee MG. JARID1D is a suppressor and prognostic marker of prostate cancer invasion and metastasis. Cancer Research. PMID 26747897 DOI: 10.1158/0008-5472.CAN-15-0906  0.48
2015 Morrow JK, Lin HK, Sun SC, Zhang S. Targeting ubiquitination for cancer therapies. Future Medicinal Chemistry. PMID 26630263 DOI: 10.4155/fmc.15.148  0.44
2015 Tsai YT, Chuang MJ, Tang SH, Wu ST, Chen YC, Sun GH, Hsiao PW, Huang SM, Lee HJ, Yu CP, Ho JY, Lin HK, Chen MR, Lin CC, Chang SY, et al. Novel Cancer Therapeutics with Allosteric Modulation of The Mitochondrial C-Raf/DAPK Complex by Raf Inhibitor Combination Therapy. Cancer Research. PMID 26100670 DOI: 10.1158/0008-5472.CAN-14-3264  0.44
2015 Jin G, Lee SW, Zhang X, Cai Z, Gao Y, Chou PC, Rezaeian AH, Han F, Wang CY, Yao JC, Gong Z, Chan CH, Huang CY, Tsai FJ, Tsai CH, ... ... Lin HK, et al. Skp2-Mediated RagA Ubiquitination Elicits a Negative Feedback to Prevent Amino-Acid-Dependent mTORC1 Hyperactivation by Recruiting GATOR1. Molecular Cell. 58: 989-1000. PMID 26051179 DOI: 10.1016/j.molcel.2015.05.010  0.44
2015 Gong L, Govan JM, Evans EB, Dai H, Wang E, Lee SW, Lin HK, Lazar AJ, Mills GB, Lin SY. Nuclear PTEN Tumor-Suppressor Functions Through Maintaining Heterochromatin Structure. Cell Cycle (Georgetown, Tex.). 0. PMID 25946202 DOI: 10.1080/15384101.2015.1044174  0.44
2015 Lee SW, Li CF, Jin G, Cai Z, Han F, Chan CH, Yang WL, Li BK, Rezaeian AH, Li HY, Huang HY, Lin HK. Skp2-dependent ubiquitination and activation of LKB1 is essential for cancer cell survival under energy stress. Molecular Cell. 57: 1022-33. PMID 25728766 DOI: 10.1016/j.molcel.2015.01.015  0.48
2015 Parameswaran B, Chiang HC, Lu Y, Coates J, Deng CX, Baer R, Lin HK, Li R, Paull TT, Hu Y. Damage-induced BRCA1 phosphorylation by Chk2 contributes to the timing of end resection. Cell Cycle (Georgetown, Tex.). 14: 437-48. PMID 25659039 DOI: 10.4161/15384101.2014.972901  0.44
2015 Chen L, Du-Cuny L, Moses S, Dumas S, Song Z, Rezaeian AH, Lin HK, Meuillet EJ, Zhang S. Novel inhibitors induce large conformational changes of GAB1 pleckstrin homology domain and kill breast cancer cells. Plos Computational Biology. 11: e1004021. PMID 25569504 DOI: 10.1371/journal.pcbi.1004021  0.44
2014 Chan CH, Jo U, Kohrman A, Rezaeian AH, Chou PC, Logothetis C, Lin HK. Posttranslational regulation of Akt in human cancer. Cell & Bioscience. 4: 59. PMID 25309720 DOI: 10.1186/2045-3701-4-59  0.48
2014 Feng H, Lopez GY, Kim CK, Alvarez A, Duncan CG, Nishikawa R, Nagane M, Su AJ, Auron PE, Hedberg ML, Wang L, Raizer JJ, Kessler JA, Parsa AT, Gao WQ, ... ... Lin HK, et al. EGFR phosphorylation of DCBLD2 recruits TRAF6 and stimulates AKT-promoted tumorigenesis. The Journal of Clinical Investigation. 124: 3741-56. PMID 25061874 DOI: 10.1172/JCI73093  0.44
2014 Lin WY, Chang CL, Fu LS, Lin CH, Lin HK. Systemic lupus erythematosus and thyroid disease: A 10-year study. Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi. PMID 24874431 DOI: 10.1016/j.jmii.2014.03.004  0.48
2014 Gao Y, Moten A, Lin HK. Akt: a new activation mechanism. Cell Research. 24: 785-6. PMID 24797432 DOI: 10.1038/cr.2014.57  0.48
2014 Gong Z, Yang J, Li J, Yang L, Le Y, Wang S, Lin HK. Novel insights into the role of microRNA in lung cancer resistance to treatment and targeted therapy. Current Cancer Drug Targets. 14: 241-58. PMID 24605945  0.6
2014 Wang J, Han F, Lee SW, Wu J, Chan CH, Zhang X, Gao Y, Su HK, Feng ZZ, Xu DZ, Lin HK. E3-ligase Skp2 regulates β-catenin expression and maintains hematopoietic stem cell homing. Biochemical and Biophysical Research Communications. 445: 566-71. PMID 24561244 DOI: 10.1016/j.bbrc.2014.02.042  0.48
2014 Chan CH, Morrow JK, Zhang S, Lin HK. Skp2: a dream target in the coming age of cancer therapy. Cell Cycle (Georgetown, Tex.). 13: 679-80. PMID 24526126 DOI: 10.4161/cc.27853  0.44
2014 Kim JH, Sharma A, Dhar SS, Lee SH, Gu B, Chan CH, Lin HK, Lee MG. UTX and MLL4 coordinately regulate transcriptional programs for cell proliferation and invasiveness in breast cancer cells. Cancer Research. 74: 1705-17. PMID 24491801 DOI: 10.1158/0008-5472.CAN-13-1896  0.48
2014 Jin G, Gao Y, Lin HK. Cytoplasmic PML: from molecular regulation to biological functions. Journal of Cellular Biochemistry. 115: 812-8. PMID 24288198 DOI: 10.1002/jcb.24727  0.48
2013 Wagner KW, Alam H, Dhar SS, Giri U, Li N, Wei Y, Giri D, Cascone T, Kim JH, Ye Y, Multani AS, Chan CH, Erez B, Saigal B, Chung J, ... Lin HK, et al. KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling. The Journal of Clinical Investigation. 123: 5231-46. PMID 24200691 DOI: 10.1172/JCI68642  0.48
2013 Qiu Q, Zheng Z, Chang L, Zhao YS, Tan C, Dandekar A, Zhang Z, Lin Z, Gui M, Li X, Zhang T, Kong Q, Li H, Chen S, Chen A, ... ... Lin HK, et al. Toll-like receptor-mediated IRE1α activation as a therapeutic target for inflammatory arthritis. The Embo Journal. 32: 2477-90. PMID 23942232 DOI: 10.1038/emboj.2013.183  0.44
2013 Chan CH, Morrow JK, Li CF, Gao Y, Jin G, Moten A, Stagg LJ, Ladbury JE, Cai Z, Xu D, Logothetis CJ, Hung MC, Zhang S, Lin HK. Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression. Cell. 154: 556-68. PMID 23911321 DOI: 10.1016/j.cell.2013.06.048  0.48
2013 Song S, Maru DM, Ajani JA, Chan CH, Honjo S, Lin HK, Correa A, Hofstetter WL, Davila M, Stroehlein J, Mishra L. Loss of TGF-β adaptor β2SP activates notch signaling and SOX9 expression in esophageal adenocarcinoma. Cancer Research. 73: 2159-69. PMID 23536563 DOI: 10.1158/0008-5472.CAN-12-1962  0.44
2013 Yang WL, Jin G, Li CF, Jeong YS, Moten A, Xu D, Feng Z, Chen W, Cai Z, Darnay B, Gu W, Lin HK. Cycles of ubiquitination and deubiquitination critically regulate growth factor-mediated activation of Akt signaling. Science Signaling. 6: ra3. PMID 23300340 DOI: 10.1126/scisignal.2003197  0.48
2013 Rezaeian AH, Gao Y, Lin HK. Cloning, expression, and functional analysis of genomic miRNA using retroviral system in cancer cells. Methods in Molecular Biology (Clifton, N.J.). 936: 157-72. PMID 23007507 DOI: 10.1007/978-1-62703-083-0_13  0.48
2012 Chan CH, Li CF, Yang WL, Gao Y, Lee SW, Feng Z, Huang HY, Tsai KKC, Flores LG, Shao Y, Hazle JD, Yu D, Wei W, Sarbassov D, Hung MC, ... ... Lin HK, et al. The Skp2-SCF E3 Ligase Regulates Akt Ubiquitination, Glycolysis, Herceptin Sensitivity, and Tumorigenesis. Cell. 151: 913-914. PMID 30360292 DOI: 10.1016/j.cell.2012.10.025  0.48
2012 Lamothe B, Lai Y, Hur L, Orozco NM, Wang J, Campos AD, Xie M, Schneider MD, Lockworth CR, Jakacky J, Tran D, Ho M, Dawud S, Dong C, Lin HK, et al. Deletion of TAK1 in the myeloid lineage results in the spontaneous development of myelomonocytic leukemia in mice. Plos One. 7: e51228. PMID 23251462 DOI: 10.1371/journal.pone.0051228  0.36
2012 Liu Y, Liu F, Yu H, Zhao X, Sashida G, Deblasio A, Harr M, She QB, Chen Z, Lin HK, Di Giandomenico S, Elf SE, Yang Y, Miyata Y, Huang G, et al. Akt phosphorylates the transcriptional repressor Bmi1 to block its effects on the tumor-suppressing Ink4a-Arf locus Science Signaling. 5. PMID 23092893 DOI: 10.1126/scisignal.2003199  0.44
2012 Chen D, Sun Y, Wei Y, Zhang P, Rezaeian AH, Teruya-Feldstein J, Gupta S, Liang H, Lin HK, Hung MC, Ma L. LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker. Nature Medicine. 18: 1511-7. PMID 23001183 DOI: 10.1038/nm.2940  0.4
2012 Wang G, Gao Y, Li L, Jin G, Cai Z, Chao JI, Lin HK. K63-linked ubiquitination in kinase activation and cancer. Frontiers in Oncology. 2: 5. PMID 22649774 DOI: 10.3389/fonc.2012.00005  0.48
2012 Chan CH, Li CF, Yang WL, Gao Y, Lee SW, Feng Z, Huang HY, Tsai KK, Flores LG, Shao Y, Hazle JD, Yu D, Wei W, Sarbassov D, Hung MC, ... ... Lin HK, et al. The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis. Cell. 149: 1098-111. PMID 22632973 DOI: 10.1016/j.cell.2012.02.065  0.44
2012 Wu J, Zhang X, Zhang L, Wu CY, Rezaeian AH, Chan CH, Li JM, Wang J, Gao Y, Han F, Jeong YS, Yuan X, Khanna KK, Jin J, Zeng YX, ... Lin HK, et al. Skp2 E3 ligase integrates ATM activation and homologous recombination repair by ubiquitinating NBS1. Molecular Cell. 46: 351-61. PMID 22464731 DOI: 10.1016/j.molcel.2012.02.018  0.48
2012 Wang G, Chan CH, Gao Y, Lin HK. Novel roles of Skp2 E3 ligase in cellular senescence, cancer progression, and metastasis. Chinese Journal of Cancer. 31: 169-77. PMID 22200179 DOI: 10.5732/cjc.011.10319  0.48
2011 Wang J, Han F, Wu J, Lee SW, Chan CH, Wu CY, Yang WL, Gao Y, Zhang X, Jeong YS, Moten A, Samaniego F, Huang P, Liu Q, Zeng YX, ... Lin HK, et al. The role of Skp2 in hematopoietic stem cell quiescence, pool size, and self-renewal. Blood. 118: 5429-38. PMID 21931116 DOI: 10.1182/blood-2010-10-312785  0.48
2011 Jane ZY, Chang CC, Lin HK, Liu YC, Chen WL. The association between the exacerbation of irritable bowel syndrome and menstrual symptoms in young Taiwanese women. Gastroenterology Nursing : the Official Journal of the Society of Gastroenterology Nurses and Associates. 34: 277-86. PMID 21814061 DOI: 10.1097/SGA.0b013e3182248708  0.52
2011 Tao RH, Berkova Z, Wise JF, Rezaeian AH, Daniluk U, Ao X, Hawke DH, Karp JE, Lin HK, Molldrem JJ, Samaniego F. PMLRARα binds to Fas and suppresses Fas-mediated apoptosis through recruiting c-FLIP in vivo. Blood. 118: 3107-18. PMID 21803845 DOI: 10.1182/blood-2011-04-349670  0.4
2011 Wu CY, Kang HY, Yang WL, Wu J, Jeong YS, Wang J, Chan CH, Lee SW, Zhang X, Lamothe B, Campos AD, Darnay BG, Lin HK. Critical role of monoubiquitination of histone H2AX protein in histone H2AX phosphorylation and DNA damage response. The Journal of Biological Chemistry. 286: 30806-15. PMID 21690091 DOI: 10.1074/jbc.M111.257469  0.56
2011 Chan CH, Gao Y, Moten A, Lin HK. Novel ARF/p53-independent senescence pathways in cancer repression. Journal of Molecular Medicine (Berlin, Germany). 89: 857-67. PMID 21594579 DOI: 10.1007/s00109-011-0766-y  0.48
2011 Chen CH, Shaikenov T, Peterson TR, Aimbetov R, Bissenbaev AK, Lee SW, Wu J, Lin HK, Sarbassov dos D. ER stress inhibits mTORC2 and Akt signaling through GSK-3β-mediated phosphorylation of rictor. Science Signaling. 4: ra10. PMID 21343617 DOI: 10.1126/scisignal.2001731  0.36
2010 Chan CH, Lee SW, Wang J, Lin HK. Regulation of Skp2 expression and activity and its role in cancer progression. Thescientificworldjournal. 10: 1001-15. PMID 20526532 DOI: 10.1100/tsw.2010.89  0.44
2010 Chan CH, Lee SW, Li CF, Wang J, Yang WL, Wu CY, Wu J, Nakayama KI, Kang HY, Huang HY, Hung MC, Pandolfi PP, Lin HK. Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis. Nature Cell Biology. 12: 457-67. PMID 20383141 DOI: 10.1038/ncb2047  0.44
2010 Lin HK, Chen Z, Wang G, Nardella C, Lee SW, Chan CH, Chan CH, Yang WL, Wang J, Egia A, Nakayama KI, Cordon-Cardo C, Teruya-Feldstein J, Pandolfi PP. Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence. Nature. 464: 374-9. PMID 20237562 DOI: 10.1038/nature08815  0.48
2010 Yang WL, Wu CY, Wu J, Lin HK. Regulation of Akt signaling activation by ubiquitination. Cell Cycle (Georgetown, Tex.). 9: 487-97. PMID 20081374  0.36
2009 Yang WL, Wang J, Chan CH, Lee SW, Campos AD, Lamothe B, Hur L, Grabiner BC, Lin X, Darnay BG, Lin HK. The E3 ligase TRAF6 regulates Akt ubiquitination and activation. Science (New York, N.Y.). 325: 1134-8. PMID 19713527 DOI: 10.1126/science.1175065  0.48
2009 Chen Z, Carracedo A, Lin HK, Koutcher JA, Behrendt N, Egia A, Alimonti A, Carver BS, Gerald W, Teruya-Feldstein J, Loda M, Pandolfi PP. Differential p53-independent outcomes of p19(Arf) loss in oncogenesis. Science Signaling. 2: ra44. PMID 19690330 DOI: 10.1126/scisignal.2000053  0.44
2009 Lin HK, Wang G, Chen Z, Teruya-Feldstein J, Liu Y, Chan CH, Yang WL, Erdjument-Bromage H, Nakayama KI, Nimer S, Tempst P, Pandolfi PP. Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB. Nature Cell Biology. 11: 420-32. PMID 19270694 DOI: 10.1038/ncb1849  0.48
2008 Chang CC, Yeh MS, Lin HK, Cheng W. The effect of Vibrio alginolyticus infection on caspase-3 expression and activity in white shrimp Litopenaeus vannamei. Fish & Shellfish Immunology. 25: 672-8. PMID 18840531 DOI: 10.1016/j.fsi.2008.09.004  0.52
2004 Lin HK, Hu YC, Lee DK, Chang C. Regulation of androgen receptor signaling by PTEN (phosphatase and tensin homolog deleted on chromosome 10) tumor suppressor through distinct mechanisms in prostate cancer cells. Molecular Endocrinology (Baltimore, Md.). 18: 2409-23. PMID 15205473 DOI: 10.1210/me.2004-0117  0.6
2004 Wang L, Lin HK, Hu YC, Xie S, Yang L, Chang C. Suppression of androgen receptor-mediated transactivation and cell growth by the glycogen synthase kinase 3 beta in prostate cells. The Journal of Biological Chemistry. 279: 32444-52. PMID 15178691 DOI: 10.1074/jbc.M313963200  0.6
2004 Kang HY, Cho CL, Huang KL, Wang JC, Hu YC, Lin HK, Chang C, Huang KE. Nongenomic androgen activation of phosphatidylinositol 3-kinase/Akt signaling pathway in MC3T3-E1 osteoblasts. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 19: 1181-90. PMID 15177002 DOI: 10.1359/JBMR.040306  0.6
2004 Hu YC, Yeh S, Yeh SD, Sampson ER, Huang J, Li P, Hsu CL, Ting HJ, Lin HK, Wang L, Kim E, Ni J, Chang C. Functional domain and motif analyses of androgen receptor coregulator ARA70 and its differential expression in prostate cancer. The Journal of Biological Chemistry. 279: 33438-46. PMID 15166229 DOI: 10.1074/jbc.M401781200  0.6
2004 Xie S, Lin HK, Ni J, Yang L, Wang L, di Sant'Agnese PA, Chang C. Regulation of interleukin-6-mediated PI3K activation and neuroendocrine differentiation by androgen signaling in prostate cancer LNCaP cells. The Prostate. 60: 61-7. PMID 15129430 DOI: 10.1002/pros.20048  0.6
2003 Altuwaijri S, Lin HK, Chuang KH, Lin WJ, Yeh S, Hanchett LA, Rahman MM, Kang HY, Tsai MY, Zhang Y, Yang L, Chang C. Interruption of nuclear factor kappaB signaling by the androgen receptor facilitates 12-O-tetradecanoylphorbolacetate-induced apoptosis in androgen-sensitive prostate cancer LNCaP cells. Cancer Research. 63: 7106-12. PMID 14612503  0.6
2003 Lin HK, Hu YC, Yang L, Altuwaijri S, Chen YT, Kang HY, Chang C. Suppression versus induction of androgen receptor functions by the phosphatidylinositol 3-kinase/Akt pathway in prostate cancer LNCaP cells with different passage numbers. The Journal of Biological Chemistry. 278: 50902-7. PMID 14555644 DOI: 10.1074/jbc.M300676200  0.6
2003 Yang L, Wang L, Lin HK, Kan PY, Xie S, Tsai MY, Wang PH, Chen YT, Chang C. Interleukin-6 differentially regulates androgen receptor transactivation via PI3K-Akt, STAT3, and MAPK, three distinct signal pathways in prostate cancer cells. Biochemical and Biophysical Research Communications. 305: 462-9. PMID 12763015 DOI: 10.1016/S0006-291X(03)00792-7  0.6
2003 Yang L, Lin HK, Altuwaijri S, Xie S, Wang L, Chang C. APPL suppresses androgen receptor transactivation via potentiating Akt activity. The Journal of Biological Chemistry. 278: 16820-7. PMID 12621049 DOI: 10.1074/jbc.M213163200  0.6
2002 Lin HK, Wang L, Hu YC, Altuwaijri S, Chang C. Phosphorylation-dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase. The Embo Journal. 21: 4037-48. PMID 12145204 DOI: 10.1093/emboj/cdf406  0.6
2002 Lin HK, Altuwaijri S, Lin WJ, Kan PY, Collins LL, Chang C. Proteasome activity is required for androgen receptor transcriptional activity via regulation of androgen receptor nuclear translocation and interaction with coregulators in prostate cancer cells. The Journal of Biological Chemistry. 277: 36570-6. PMID 12119296 DOI: 10.1074/jbc.M204751200  0.6
2001 Lin HK, Yeh S, Kang HY, Chang C. Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor. Proceedings of the National Academy of Sciences of the United States of America. 98: 7200-5. PMID 11404460 DOI: 10.1073/pnas.121173298  0.6
2001 Kang HY, Lin HK, Hu YC, Yeh S, Huang KE, Chang C. From transforming growth factor-beta signaling to androgen action: identification of Smad3 as an androgen receptor coregulator in prostate cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 98: 3018-23. PMID 11248024 DOI: 10.1073/pnas.061305498  0.6
2000 Yeh S, Hu YC, Rahman M, Lin HK, Hsu CL, Ting HJ, Kang HY, Chang C. Increase of androgen-induced cell death and androgen receptor transactivation by BRCA1 in prostate cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 97: 11256-61. PMID 11016951 DOI: 10.1073/pnas.190353897  0.6
1999 Yeh S, Kang HY, Miyamoto H, Nishimura K, Chang HC, Ting HJ, Rahman M, Lin HK, Fujimoto N, Hu YC, Mizokami A, Huang KE, Chang C. Differential induction of androgen receptor transactivation by different androgen receptor coactivators in human prostate cancer DU145 cells. Endocrine. 11: 195-202. PMID 10709768 DOI: 10.1385/ENDO:11:2:195  0.6
1999 Yeh S, Chang HC, Miyamoto H, Takatera H, Rahman M, Kang HY, Thin TH, Lin HK, Chang C. Differential induction of the androgen receptor transcriptional activity by selective androgen receptor coactivators. The Keio Journal of Medicine. 48: 87-92. PMID 10405524  0.6
1999 Yeh S, Lin HK, Kang HY, Thin TH, Lin MF, Chang C. From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 96: 5458-63. PMID 10318905  0.6
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