Ken M. Hargreaves - Publications

Affiliations: 
University of Texas Health Science Center at San Antonio, San Antonio, TX, United States 
Area:
pain, inflammation, analagesics
Website:
http://pharmacology.uthscsa.edu/faculty/Hargreaves.html

207 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Hargreaves KM, Ruparel S. Role of Oxidized Lipids and TRP Channels in Orofacial Pain and Inflammation. Journal of Dental Research. PMID 27307050 DOI: 10.1177/0022034516653751  1
2016 Diogenes A, Ruparel NB, Shiloah Y, Hargreaves KM. Regenerative endodontics: A way forward. Journal of the American Dental Association (1939). PMID 27017182 DOI: 10.1016/j.adaj.2016.01.009  1
2016 Hargreaves KM. Adding Regenerative Endodontics to the Table of Contents. Journal of Endodontics. 42: 1. PMID 26699922 DOI: 10.1016/j.joen.2015.11.001  1
2015 Eskander MA, Ruparel S, Green DP, Chen PB, Por ED, Jeske NA, Gao X, Flores ER, Hargreaves KM. Persistent Nociception Triggered by Nerve Growth Factor (NGF) Is Mediated by TRPV1 and Oxidative Mechanisms. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 8593-603. PMID 26041925 DOI: 10.1523/JNEUROSCI.3993-14.2015  1
2015 Dissanayaka WL, Zhu L, Hargreaves KM, Jin L, Zhang C. In vitro analysis of scaffold-free prevascularized microtissue spheroids containing human dental pulp cells and endothelial cells. Journal of Endodontics. 41: 663-70. PMID 25687363 DOI: 10.1016/j.joen.2014.12.017  1
2015 Dissanayaka WL, Hargreaves KM, Jin L, Samaranayake LP, Zhang C. The interplay of dental pulp stem cells and endothelial cells in an injectable peptide hydrogel on angiogenesis and pulp regeneration in vivo. Tissue Engineering. Part A. 21: 550-63. PMID 25203774 DOI: 10.1089/ten.TEA.2014.0154  1
2015 Fehrenbacher JC, Bingener J, Aho JM, Wasky PR, Locke EE, Schwesinger WH, Van Sickle KR, Hargreaves KM. Men with acute cholecystitis have higher tissue-based cytokine levels than women: A cross-sectional study Chirurgia (Turin). 28: 49-53.  1
2014 Dissanayaka WL, Zhu L, Hargreaves KM, Jin L, Zhang C. Scaffold-free Prevascularized Microtissue Spheroids for Pulp Regeneration. Journal of Dental Research. 93: 1296-303. PMID 25201919 DOI: 10.1177/0022034514550040  1
2014 Chrepa V, Kotsakis GA, Pagonis TC, Hargreaves KM. The effect of photodynamic therapy in root canal disinfection: a systematic review. Journal of Endodontics. 40: 891-8. PMID 24935531 DOI: 10.1016/j.joen.2014.03.005  1
2014 Rowan MP, Berg KA, Roberts JL, Hargreaves KM, Clarke WP. Activation of estrogen receptor α enhances bradykinin signaling in peripheral sensory neurons of female rats. The Journal of Pharmacology and Experimental Therapeutics. 349: 526-32. PMID 24706985 DOI: 10.1124/jpet.114.212977  1
2014 Hargreaves KM, Diogenes A, Teixeira FB. Paradigm lost: a perspective on the design and interpretation of regenerative endodontic research. Journal of Endodontics. 40: S65-9. PMID 24698697 DOI: 10.1016/j.joen.2014.01.023  1
2014 Diogenes AR, Ruparel NB, Teixeira FB, Hargreaves KM. Translational science in disinfection for regenerative endodontics. Journal of Endodontics. 40: S52-7. PMID 24698694 DOI: 10.1016/j.joen.2014.01.015  1
2014 Gonzales CB, Kirma NB, De La Chapa JJ, Chen R, Henry MA, Luo S, Hargreaves KM. Vanilloids induce oral cancer apoptosis independent of TRPV1. Oral Oncology. 50: 437-47. PMID 24434067 DOI: 10.1016/j.oraloncology.2013.12.023  1
2014 Flake NM, Gibbs JL, Diogenes A, Hargreaves KM, Khan AA. A standardized novel method to measure radiographic root changes after endodontic therapy in immature teeth. Journal of Endodontics. 40: 46-50. PMID 24331990 DOI: 10.1016/j.joen.2013.09.025  1
2014 Hargreaves KM, Diogenes A, Teixeira FB. Pulp Injury and Changing Trends in Treatment Stem Cell Biology and Tissue Engineering in Dental Sciences. 397-404. DOI: 10.1016/B978-0-12-397157-9.00035-7  1
2013 Rowan S, Hua J, Hargreaves K. Penicillin not effective for preoperative irreversible pulpitis pain (UT CAT #2244). Texas Dental Journal. 130: 436. PMID 23923465  1
2013 Green DP, Ruparel S, Roman L, Henry MA, Hargreaves KM. Role of endogenous TRPV1 agonists in a postburn pain model of partial-thickness injury. Pain. 154: 2512-20. PMID 23891895 DOI: 10.1016/j.pain.2013.07.040  1
2013 Ruparel S, Hargreaves KM, Eskander M, Rowan S, de Almeida JF, Roman L, Henry MA. Oxidized linoleic acid metabolite-cytochrome P450 system (OLAM-CYP) is active in biopsy samples from patients with inflammatory dental pain. Pain. 154: 2363-71. PMID 23867730 DOI: 10.1016/j.pain.2013.07.011  1
2013 Brandfellner HM, Ruparel SB, Gelfond JA, Hargreaves KM. Major blunt trauma evokes selective upregulation of oxidative enzymes in circulating leukocytes. Shock (Augusta, Ga.). 40: 182-7. PMID 23817354 DOI: 10.1097/SHK.0b013e31829de02f  1
2013 Hargreaves KM, Diogenes A, Teixeira FB. Treatment options: biological basis of regenerative endodontic procedures. Pediatric Dentistry. 35: 129-40. PMID 23635981  1
2013 Niu LN, Jiao K, Ryou H, Diogenes A, Yiu CK, Mazzoni A, Chen JH, Arola DD, Hargreaves KM, Pashley DH, Tay FR. Biomimetic silicification of demineralized hierarchical collagenous tissues. Biomacromolecules. 14: 1661-8. PMID 23586938 DOI: 10.1021/bm400316e  1
2013 Hargreaves KM, Diogenes A, Teixeira FB. Treatment options: biological basis of regenerative endodontic procedures. Journal of Endodontics. 39: S30-43. PMID 23439043 DOI: 10.1016/j.joen.2012.11.025  1
2013 Loyd DR, Henry MA, Hargreaves KM. Serotonergic neuromodulation of peripheral nociceptors. Seminars in Cell & Developmental Biology. 24: 51-7. PMID 23000387 DOI: 10.1016/j.semcdb.2012.09.002  1
2012 Ruparel S, Green D, Chen P, Hargreaves KM. The cytochrome P450 inhibitor, ketoconazole, inhibits oxidized linoleic acid metabolite-mediated peripheral inflammatory pain. Molecular Pain. 8: 73. PMID 23006841 DOI: 10.1186/1744-8069-8-73  1
2012 Jeeruphan T, Jantarat J, Yanpiset K, Suwannapan L, Khewsawai P, Hargreaves KM. Mahidol study 1: comparison of radiographic and survival outcomes of immature teeth treated with either regenerative endodontic or apexification methods: a retrospective study. Journal of Endodontics. 38: 1330-6. PMID 22980172 DOI: 10.1016/j.joen.2012.06.028  1
2012 Jung IY, Lee SJ, Hargreaves KM. Biologically based treatment of immature permanent teeth with pulpal necrosis: a case series. Texas Dental Journal. 129: 601-16. PMID 22866415  1
2012 Niu LN, Jiao K, Qi YP, Nikonov S, Yiu CK, Arola DD, Gong SQ, El-Marakby A, Carrilho MR, Hamrick MW, Hargreaves KM, Diogenes A, Chen JH, Pashley DH, Tay FR. Intrafibrillar silicification of collagen scaffolds for sustained release of stem cell homing chemokine in hard tissue regeneration. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 4517-29. PMID 22859369 DOI: 10.1096/fj.12-210211  1
2012 Loyd DR, Sun XX, Locke EE, Salas MM, Hargreaves KM. Sex differences in serotonin enhancement of capsaicin-evoked calcitonin gene-related peptide release from human dental pulp. Pain. 153: 2061-7. PMID 22819536 DOI: 10.1016/j.pain.2012.06.018  1
2012 Ruparel S, Henry MA, Akopian A, Patil M, Zeldin DC, Roman L, Hargreaves KM. Plasticity of cytochrome P450 isozyme expression in rat trigeminal ganglia neurons during inflammation. Pain. 153: 2031-9. PMID 22633978 DOI: 10.1016/j.pain.2012.04.027  1
2012 Dissanayaka WL, Zhan X, Zhang C, Hargreaves KM, Jin L, Tong EH. Coculture of dental pulp stem cells with endothelial cells enhances osteo-/odontogenic and angiogenic potential in vitro. Journal of Endodontics. 38: 454-63. PMID 22414829 DOI: 10.1016/j.joen.2011.12.024  1
2012 Loyd DR, Chen PB, Hargreaves KM. Anti-hyperalgesic effects of anti-serotonergic compounds on serotonin- and capsaicin-evoked thermal hyperalgesia in the rat. Neuroscience. 203: 207-15. PMID 22209919 DOI: 10.1016/j.neuroscience.2011.12.019  1
2012 Berg KA, Rowan MP, Gupta A, Sanchez TA, Silva M, Gomes I, McGuire BA, Portoghese PS, Hargreaves KM, Devi LA, Clarke WP. Allosteric interactions between δ and κ opioid receptors in peripheral sensory neurons. Molecular Pharmacology. 81: 264-72. PMID 22072818 DOI: 10.1124/mol.111.072702  1
2012 Hargreaves KM, Goldberg RA. JOE on the go Journal of Endodontics. 38: 1163. DOI: 10.1016/j.joen.2012.06.001  1
2011 Scotland PE, Patil M, Belugin S, Henry MA, Goffin V, Hargreaves KM, Akopian AN. Endogenous prolactin generated during peripheral inflammation contributes to thermal hyperalgesia. The European Journal of Neuroscience. 34: 745-54. PMID 21777304 DOI: 10.1111/j.1460-9568.2011.07788.x  1
2011 Trevino EG, Patwardhan AN, Henry MA, Perry G, Dybdal-Hargreaves N, Hargreaves KM, Diogenes A. Effect of irrigants on the survival of human stem cells of the apical papilla in a platelet-rich plasma scaffold in human root tips. Journal of Endodontics. 37: 1109-15. PMID 21763903 DOI: 10.1016/j.joen.2011.05.013  1
2011 Bowles WR, Burke R, Sabino M, Harding-Rose C, Lunos S, Hargreaves KM. Sex differences in neuropeptide content and release from rat dental pulp. Journal of Endodontics. 37: 1098-101. PMID 21763901 DOI: 10.1016/j.joen.2011.03.007  1
2011 Loyd DR, Weiss G, Henry MA, Hargreaves KM. Serotonin increases the functional activity of capsaicin-sensitive rat trigeminal nociceptors via peripheral serotonin receptors. Pain. 152: 2267-76. PMID 21737202 DOI: 10.1016/j.pain.2011.06.002  1
2011 Patil M, Patwardhan A, Salas MM, Hargreaves KM, Akopian AN. Cannabinoid receptor antagonists AM251 and AM630 activate TRPA1 in sensory neurons. Neuropharmacology. 61: 778-88. PMID 21645531 DOI: 10.1016/j.neuropharm.2011.05.024  1
2011 Berg KA, Rowan MP, Sanchez TA, Silva M, Patwardhan AM, Milam SB, Hargreaves KM, Clarke WP. Regulation of κ-opioid receptor signaling in peripheral sensory neurons in vitro and in vivo. The Journal of Pharmacology and Experimental Therapeutics. 338: 92-9. PMID 21487072 DOI: 10.1124/jpet.110.177493  1
2011 Ruparel NB, Patwardhan AM, Akopian AN, Hargreaves KM. Desensitization of transient receptor potential ankyrin 1 (TRPA1) by the TRP vanilloid 1-selective cannabinoid arachidonoyl-2 chloroethanolamine. Molecular Pharmacology. 80: 117-23. PMID 21441412 DOI: 10.1124/mol.110.068940  1
2011 Diogenes A, Ferraz CC, Akopian AN, Henry MA, Hargreaves KM. LPS sensitizes TRPV1 via activation of TLR4 in trigeminal sensory neurons. Journal of Dental Research. 90: 759-64. PMID 21393555 DOI: 10.1177/0022034511400225  1
2011 Hargreaves KM. Orofacial pain. Pain. 152: S25-32. PMID 21292394 DOI: 10.1016/j.pain.2010.12.024  1
2011 Lovelace TW, Henry MA, Hargreaves KM, Diogenes A. Evaluation of the delivery of mesenchymal stem cells into the root canal space of necrotic immature teeth after clinical regenerative endodontic procedure. Journal of Endodontics. 37: 133-8. PMID 21238791 DOI: 10.1016/j.joen.2010.10.009  1
2011 Ferraz CC, Henry MA, Hargreaves KM, Diogenes A. Lipopolysaccharide from Porphyromonas gingivalis sensitizes capsaicin-sensitive nociceptors. Journal of Endodontics. 37: 45-8. PMID 21146075 DOI: 10.1016/j.joen.2007.07.001  1
2011 Lautner MA, Ruparel SB, Patil MJ, Hargreaves KM. In vitro sarcoma cells release a lipophilic substance that activates the pain transduction system via TRPV1. Annals of Surgical Oncology. 18: 866-71. PMID 20842457 DOI: 10.1245/s10434-010-1328-1  1
2010 McNamara RP, Henry MA, Schindler WG, Hargreaves KM. Biocompatibility of accelerated mineral trioxide aggregate in a rat model. Journal of Endodontics. 36: 1851-5. PMID 20951299 DOI: 10.1016/j.joen.2010.08.021  1
2010 Rowan MP, Berg KA, Milam SB, Jeske NA, Roberts JL, Hargreaves KM, Clarke WP. 17beta-estradiol rapidly enhances bradykinin signaling in primary sensory neurons in vitro and in vivo. The Journal of Pharmacology and Experimental Therapeutics. 335: 190-6. PMID 20647494 DOI: 10.1124/jpet.110.167445  1
2010 Patwardhan AM, Akopian AN, Ruparel NB, Diogenes A, Weintraub ST, Uhlson C, Murphy RC, Hargreaves KM. Heat generates oxidized linoleic acid metabolites that activate TRPV1 and produce pain in rodents. The Journal of Clinical Investigation. 120: 1617-26. PMID 20424317 DOI: 10.1172/JCI41678  1
2010 Hargreaves KM. Capsicum and local anesthetic cocktails for trigeminal pain. Pain. 150: 3. PMID 20356676 DOI: 10.1016/j.pain.2010.03.008  1
2010 Khan A, Hargreaves KM. Animal models of orofacial pain. Methods in Molecular Biology (Clifton, N.J.). 617: 93-104. PMID 20336416 DOI: 10.1007/978-1-60327-323-7_8  1
2010 Hargreaves KM, Law A. The wrong emperor. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics. 109: 327-8; author reply . PMID 20219596 DOI: 10.1016/j.tripleo.2009.11.017  1
2010 Hargreaves KM, Diogenes A. Effects of cxytocin and prolactin on stress-induced bladder hypersensitivity in female rats. The Journal of Pain : Official Journal of the American Pain Society. 11: 197; author reply 19. PMID 20152775 DOI: 10.1016/j.jpain.2009.11.004  1
2010 Bereiter DA, Hargreaves KM, Hu JW. Trigeminal Mechanisms of Nociception: Peripheral and Brainstem Organization The Senses: a Comprehensive Reference. 5: 435-460. DOI: 10.1016/B978-012370880-9.00174-2  1
2009 Glickman GN, Bakland LK, Fouad AF, Hargreaves KM, Schwartz SA. Diagnostic terminology: report of an online survey. Journal of Endodontics. 35: 1625-33. PMID 19932337 DOI: 10.1016/j.joen.2009.09.034  1
2009 Patwardhan AM, Scotland PE, Akopian AN, Hargreaves KM. Activation of TRPV1 in the spinal cord by oxidized linoleic acid metabolites contributes to inflammatory hyperalgesia. Proceedings of the National Academy of Sciences of the United States of America. 106: 18820-4. PMID 19843694 DOI: 10.1073/pnas.0905415106  1
2009 Bose R, Nummikoski P, Hargreaves K. A retrospective evaluation of radiographic outcomes in immature teeth with necrotic root canal systems treated with regenerative endodontic procedures. Journal of Endodontics. 35: 1343-9. PMID 19801227 DOI: 10.1016/j.joen.2009.06.021  1
2009 Simonton JD, Azevedo B, Schindler WG, Hargreaves KM. Age- and gender-related differences in the position of the inferior alveolar nerve by using cone beam computed tomography. Journal of Endodontics. 35: 944-9. PMID 19567312 DOI: 10.1016/j.joen.2009.04.032  1
2009 Fehrenbacher JC, Sun XX, Locke EE, Henry MA, Hargreaves KM. Capsaicin-evoked iCGRP release from human dental pulp: a model system for the study of peripheral neuropeptide secretion in normal healthy tissue. Pain. 144: 253-61. PMID 19428185 DOI: 10.1016/j.pain.2009.03.027  1
2009 Salas MM, Hargreaves KM, Akopian AN. TRPA1-mediated responses in trigeminal sensory neurons: interaction between TRPA1 and TRPV1. The European Journal of Neuroscience. 29: 1568-78. PMID 19419422 DOI: 10.1111/j.1460-9568.2009.06702.x  1
2009 Fehrenbacher JC, Loverme J, Clarke W, Hargreaves KM, Piomelli D, Taylor BK. Rapid pain modulation with nuclear receptor ligands. Brain Research Reviews. 60: 114-24. PMID 19162071 DOI: 10.1016/j.brainresrev.2008.12.019  1
2009 Akopian AN, Ruparel NB, Jeske NA, Patwardhan A, Hargreaves KM. Role of ionotropic cannabinoid receptors in peripheral antinociception and antihyperalgesia. Trends in Pharmacological Sciences. 30: 79-84. PMID 19070372 DOI: 10.1016/j.tips.2008.10.008  1
2009 Rowan MP, Ruparel NB, Patwardhan AM, Berg KA, Clarke WP, Hargreaves KM. Peripheral delta opioid receptors require priming for functional competence in vivo. European Journal of Pharmacology. 602: 283-7. PMID 19063879 DOI: 10.1016/j.ejphar.2008.11.028  1
2008 Khan AA, Sun X, Hargreaves KM. Effect of calcium hydroxide on proinflammatory cytokines and neuropeptides. Journal of Endodontics. 34: 1360-3. PMID 18928847 DOI: 10.1016/j.joen.2008.08.020  1
2008 Gibbs JL, Hargreaves KM. Neuropeptide Y Y1 receptor effects on pulpal nociceptors. Journal of Dental Research. 87: 948-52. PMID 18809749 DOI: 10.1177/154405910808701008  1
2008 Hargreaves KM, Geisler T, Giesler T, Henry M, Wang Y. Regeneration potential of the young permanent tooth: what does the future hold? Pediatric Dentistry. 30: 253-60. PMID 18615992  1
2008 Khan AA, Diogenes A, Jeske NA, Henry MA, Akopian A, Hargreaves KM. Tumor necrosis factor alpha enhances the sensitivity of rat trigeminal neurons to capsaicin. Neuroscience. 155: 503-9. PMID 18582539 DOI: 10.1016/j.neuroscience.2008.05.036  1
2008 Jung IY, Lee SJ, Hargreaves KM. Biologically based treatment of immature permanent teeth with pulpal necrosis: a case series. Journal of Endodontics. 34: 876-87. PMID 18571000 DOI: 10.1016/j.joen.2008.03.023  1
2008 Cotton TP, Schindler WG, Schwartz SA, Watson WR, Hargreaves KM. A retrospective study comparing clinical outcomes after obturation with Resilon/Epiphany or Gutta-Percha/Kerr sealer. Journal of Endodontics. 34: 789-97. PMID 18570981 DOI: 10.1016/j.joen.2008.03.018  1
2008 Hargreaves KM, Giesler T, Henry M, Wang Y. Regeneration potential of the young permanent tooth: what does the future hold? Journal of Endodontics. 34: S51-6. PMID 18565373 DOI: 10.1016/j.joen.2008.02.032  1
2008 Jeske NA, Diogenes A, Ruparel NB, Fehrenbacher JC, Henry M, Akopian AN, Hargreaves KM. A-kinase anchoring protein mediates TRPV1 thermal hyperalgesia through PKA phosphorylation of TRPV1. Pain. 138: 604-16. PMID 18381233 DOI: 10.1016/j.pain.2008.02.022  1
2008 Patwardhan AM, Vela J, Farugia J, Vela K, Hargreaves KM. Trigeminal nociceptors express prostaglandin receptors. Journal of Dental Research. 87: 262-6. PMID 18296611 DOI: 10.1177/154405910808700306  1
2008 Akopian AN, Ruparel NB, Patwardhan A, Hargreaves KM. Cannabinoids desensitize capsaicin and mustard oil responses in sensory neurons via TRPA1 activation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 1064-75. PMID 18234885 DOI: 10.1523/JNEUROSCI.1565-06.2008  1
2008 Ruparel NB, Patwardhan AM, Akopian AN, Hargreaves KM. Homologous and heterologous desensitization of capsaicin and mustard oil responses utilize different cellular pathways in nociceptors. Pain. 135: 271-9. PMID 17590514 DOI: 10.1016/j.pain.2007.06.005  1
2007 Hargreaves KM. Save the baby. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics. 104: 730; author reply 73. PMID 17900940 DOI: 10.1016/j.tripleo.2007.07.036  1
2007 Kitchens JA, Schwartz SA, Schindler WG, Hargreaves KM. Iontophoresis significantly increases the trans-dentinal delivery of osteoprotegerin, alendronate, and calcitonin. Journal of Endodontics. 33: 1208-11. PMID 17889691 DOI: 10.1016/j.joen.2007.06.017  1
2007 Alvarado LT, Perry GM, Hargreaves KM, Henry MA. TRPM8 Axonal expression is decreased in painful human teeth with irreversible pulpitis and cold hyperalgesia. Journal of Endodontics. 33: 1167-71. PMID 17889683 DOI: 10.1016/j.joen.2007.06.018  1
2007 Khan AA, Owatz CB, Schindler WG, Schwartz SA, Keiser K, Hargreaves KM. Measurement of mechanical allodynia and local anesthetic efficacy in patients with irreversible pulpitis and acute periradicular periodontitis. Journal of Endodontics. 33: 796-9. PMID 17804314 DOI: 10.1016/j.joen.2007.01.021  1
2007 Akopian AN, Ruparel NB, Jeske NA, Hargreaves KM. Transient receptor potential TRPA1 channel desensitization in sensory neurons is agonist dependent and regulated by TRPV1-directed internalization. The Journal of Physiology. 583: 175-93. PMID 17584831 DOI: 10.1113/jphysiol.2007.133231  1
2007 Diogenes A, Akopian AN, Hargreaves KM. NGF up-regulates TRPA1: implications for orofacial pain. Journal of Dental Research. 86: 550-5. PMID 17525356 DOI: 10.1177/154405910708600612  1
2007 Khan AA, McCreary B, Owatz CB, Schindler WG, Schwartz SA, Keiser K, Hargreaves KM. The development of a diagnostic instrument for the measurement of mechanical allodynia. Journal of Endodontics. 33: 663-6. PMID 17509402 DOI: 10.1016/j.joen.2006.06.003  1
2007 Owatz CB, Khan AA, Schindler WG, Schwartz SA, Keiser K, Hargreaves KM. The incidence of mechanical allodynia in patients with irreversible pulpitis. Journal of Endodontics. 33: 552-6. PMID 17437870 DOI: 10.1016/j.joen.2007.01.023  1
2007 Murray PE, Garcia-Godoy F, Hargreaves KM. Regenerative endodontics: a review of current status and a call for action. Journal of Endodontics. 33: 377-90. PMID 17368324 DOI: 10.1016/j.joen.2006.09.013  1
2007 Berg KA, Patwardhan AM, Sanchez TA, Silva YM, Hargreaves KM, Clarke WP. Rapid modulation of micro-opioid receptor signaling in primary sensory neurons. The Journal of Pharmacology and Experimental Therapeutics. 321: 839-47. PMID 17347322 DOI: 10.1124/jpet.106.116681  1
2007 Henry MA, Hargreaves KM. Peripheral mechanisms of odontogenic pain. Dental Clinics of North America. 51: 19-44, v. PMID 17185058 DOI: 10.1016/j.cden.2006.09.007  1
2007 Berg KA, Zardeneta G, Hargreaves KM, Clarke WP, Milam SB. Integrins regulate opioid receptor signaling in trigeminal ganglion neurons. Neuroscience. 144: 889-97. PMID 17157995 DOI: 10.1016/j.neuroscience.2006.10.033  1
2007 Gibbs JL, Diogenes A, Hargreaves KM. Neuropeptide Y modulates effects of bradykinin and prostaglandin E2 on trigeminal nociceptors via activation of the Y1 and Y2 receptors. British Journal of Pharmacology. 150: 72-9. PMID 17143304 DOI: 10.1038/sj.bjp.0706967  1
2007 Murray PE, Garcia-Godoy F, Hargreaves KM. Reply Journal of Endodontics. 33: 1277. DOI: 10.1016/j.joen.2007.07.032  1
2006 Hargreaves KM, Balson M. Findings questioned. Journal of the American Dental Association (1939). 137: 1500, 1502; author r. PMID 17082270  1
2006 Goodis HE, Poon A, Hargreaves KM. Tissue pH and temperature regulate pulpal nociceptors. Journal of Dental Research. 85: 1046-9. PMID 17062748 DOI: 10.1177/154405910608501114  1
2006 Jeske NA, Patwardhan AM, Gamper N, Price TJ, Akopian AN, Hargreaves KM. Cannabinoid WIN 55,212-2 regulates TRPV1 phosphorylation in sensory neurons. The Journal of Biological Chemistry. 281: 32879-90. PMID 16954222 DOI: 10.1074/jbc.M603220200  1
2006 Price TJ, Hargreaves KM, Cervero F. Protein expression and mRNA cellular distribution of the NKCC1 cotransporter in the dorsal root and trigeminal ganglia of the rat. Brain Research. 1112: 146-58. PMID 16904086 DOI: 10.1016/j.brainres.2006.07.012  1
2006 Diogenes A, Patwardhan AM, Jeske NA, Ruparel NB, Goffin V, Akopian AN, Hargreaves KM. Prolactin modulates TRPV1 in female rat trigeminal sensory neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 8126-36. PMID 16885226 DOI: 10.1523/JNEUROSCI.0793-06.2006  1
2006 Patwardhan AM, Jeske NA, Price TJ, Gamper N, Akopian AN, Hargreaves KM. The cannabinoid WIN 55,212-2 inhibits transient receptor potential vanilloid 1 (TRPV1) and evokes peripheral antihyperalgesia via calcineurin. Proceedings of the National Academy of Sciences of the United States of America. 103: 11393-8. PMID 16849427 DOI: 10.1073/pnas.0603861103  1
2006 Price TJ, Flores CM, Cervero F, Hargreaves KM. The RNA binding and transport proteins staufen and fragile X mental retardation protein are expressed by rat primary afferent neurons and localize to peripheral and central axons. Neuroscience. 141: 2107-16. PMID 16809002 DOI: 10.1016/j.neuroscience.2006.05.047  1
2006 Patwardhan AM, Diogenes A, Berg KA, Fehrenbacher JC, Clarke WP, Akopian AN, Hargreaves KM. PAR-2 agonists activate trigeminal nociceptors and induce functional competence in the delta opioid receptor. Pain. 125: 114-24. PMID 16781076 DOI: 10.1016/j.pain.2006.05.007  1
2006 Bowles WR, Sabino M, Harding-Rose C, Hargreaves KM. Chronic nerve growth factor administration increases the peripheral exocytotic activity of capsaicin-sensitive cutaneous neurons. Neuroscience Letters. 403: 305-8. PMID 16777323 DOI: 10.1016/j.neulet.2006.05.020  1
2006 Gibbs JL, Flores CM, Hargreaves KM. Attenuation of capsaicin-evoked mechanical allodynia by peripheral neuropeptide Y Y1 receptors. Pain. 124: 167-74. PMID 16714086 DOI: 10.1016/j.pain.2006.04.013  1
2006 Hargreaves KM. Re: The use of an intra-oral injection of ketorolac in the treatment of irreversible pulpitis. International Endodontic Journal. 39: 334-5; author reply . PMID 16584501 DOI: 10.1111/j.1365-2591.2006.01118_1.x  1
2006 Hargreaves KM. Single-visit more effective than multiple-visit root canal treatment? Evidence-Based Dentistry. 7: 13-4. PMID 16557250 DOI: 10.1038/sj.ebd.6400372  1
2006 Schilder H, Hargreaves KM. Filling root canals in three dimensions Journal of Endodontics. 32: 281-290. PMID 16554195 DOI: 10.1016/j.joen.2006.02.007  1
2006 Hargreaves KM. Peripheral opioid regulation of nociceptors. Focus on "morphine directly inhibits nociceptors in inflamed skin". Journal of Neurophysiology. 95: 2031. PMID 16551840 DOI: 10.1152/jn.00031.2006  1
2006 Hargreaves KM. Stay tuned. Journal of Endodontics. 32: 83-4. PMID 16427449 DOI: 10.1016/j.joen.2005.12.011  1
2006 Wadachi R, Hargreaves KM. Trigeminal nociceptors express TLR-4 and CD14: a mechanism for pain due to infection. Journal of Dental Research. 85: 49-53. PMID 16373680 DOI: 10.1177/154405910608500108  1
2005 Patwardhan AM, Berg KA, Akopain AN, Jeske NA, Gamper N, Clarke WP, Hargreaves KM. Bradykinin-induced functional competence and trafficking of the delta-opioid receptor in trigeminal nociceptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 8825-32. PMID 16192372 DOI: 10.1523/JNEUROSCI.0160-05.2005  1
2005 Price TJ, Jeske NA, Flores CM, Hargreaves KM. Pharmacological interactions between calcium/calmodulin-dependent kinase II alpha and TRPV1 receptors in rat trigeminal sensory neurons. Neuroscience Letters. 389: 94-8. PMID 16095822 DOI: 10.1016/j.neulet.2005.07.029  1
2005 Price TJ, Patwardhan AM, Flores CM, Hargreaves KM. A role for the anandamide membrane transporter in TRPV1-mediated neurosecretion from trigeminal sensory neurons. Neuropharmacology. 49: 25-39. PMID 15992578 DOI: 10.1016/j.neuropharm.2005.01.031  1
2005 Price TJ, Louria MD, Candelario-Soto D, Dussor GO, Jeske NA, Patwardhan AM, Diogenes A, Trott AA, Hargreaves KM, Flores CM. Treatment of trigeminal ganglion neurons in vitro with NGF, GDNF or BDNF: effects on neuronal survival, neurochemical properties and TRPV1-mediated neuropeptide secretion. Bmc Neuroscience. 6: 4. PMID 15667652 DOI: 10.1186/1471-2202-6-4  1
2005 Hargreaves KM. From consent to CONSORT: clinical research in the 21st century. Journal of Endodontics. 31: 1-3. PMID 15613997 DOI: 10.1097/01.DON.0000151123.44369.0b  1
2004 Hargreaves KM. On the shoulders of giants. Journal of Endodontics. 30: 683. PMID 15448458  1
2004 Hargreaves KM, Keiser K. New advances in the management of endodontic pain emergencies. Journal of the California Dental Association. 32: 469-73. PMID 15344437  1
2004 Hargreaves KM. Legitimate to extrapolate efficacy from one pain context to another. Evidence-Based Dentistry. 5: 42. PMID 15238952 DOI: 10.1038/sj.ebd.6400255  1
2004 Bowles WR, Sabino M, Harding-Rose C, Hargreaves KM. Nerve growth factor treatment enhances release of immunoreactive calcitonin gene-related peptide but not substance P from spinal dorsal horn slices in rats. Neuroscience Letters. 363: 239-42. PMID 15182951 DOI: 10.1016/j.neulet.2004.03.068  1
2004 Price TJ, Patwardhan A, Akopian AN, Hargreaves KM, Flores CM. Cannabinoid receptor-independent actions of the aminoalkylindole WIN 55,212-2 on trigeminal sensory neurons. British Journal of Pharmacology. 142: 257-66. PMID 15155534 DOI: 10.1038/sj.bjp.0705778  1
2004 Gibbs J, Flores CM, Hargreaves KM. Neuropeptide Y inhibits capsaicin-sensitive nociceptors via a Y1-receptor-mediated mechanism. Neuroscience. 125: 703-9. PMID 15099684 DOI: 10.1016/j.neuroscience.2004.01.044  1
2004 Price TJ, Patwardhan A, Akopian AN, Hargreaves KM, Flores CM. Modulation of trigeminal sensory neuron activity by the dual cannabinoid-vanilloid agonists anandamide, N-arachidonoyl-dopamine and arachidonyl-2-chloroethylamide. British Journal of Pharmacology. 141: 1118-30. PMID 15006899 DOI: 10.1038/sj.bjp.0705711  1
2004 Dussor GO, Helesic G, Hargreaves KM, Flores CM. Cholinergic modulation of nociceptive responses in vivo and neuropeptide release in vitro at the level of the primary sensory neuron. Pain. 107: 22-32. PMID 14715385 DOI: 10.1016/j.pain.2003.09.022  1
2004 Hargreaves KM. Introducing letters to the editor Journal of Endodontics. 30: 825.  1
2004 Hargreaves KM. Editorial: On the shoulders of giants Journal of Endodontics. 30: 683.  1
2004 Hargreaves KM. A tribute to Dr. Samuel Seltzer Journal of Endodontics. 30: 461.  1
2003 Dussor GO, Leong AS, Gracia NB, Kilo S, Price TJ, Hargreaves KM, Flores CM. Potentiation of evoked calcitonin gene-related peptide release from oral mucosa: a potential basis for the pro-inflammatory effects of nicotine. The European Journal of Neuroscience. 18: 2515-26. PMID 14622152 DOI: 10.1046/j.1460-9568.2003.02935.x  1
2003 Mowa CN, Usip S, Collins J, Storey-Workley M, Hargreaves KM, Papka RE. The effects of pregnancy and estrogen on the expression of calcitonin gene-related peptide (CGRP) in the uterine cervix, dorsal root ganglia and spinal cord. Peptides. 24: 1163-74. PMID 14612187 DOI: 10.1016/j.peptides.2003.07.009  1
2003 Littlefield JH, Demps EL, Keiser K, Chatterjee L, Yuan CH, Hargreaves KM. A multimedia patient simulation for teaching and assessing endodontic diagnosis. Journal of Dental Education. 67: 669-77. PMID 12856967  1
2003 Price TJ, Helesic G, Parghi D, Hargreaves KM, Flores CM. The neuronal distribution of cannabinoid receptor type 1 in the trigeminal ganglion of the rat. Neuroscience. 120: 155-62. PMID 12849749 DOI: 10.1016/S0306-4522(03)00333-6  1
2003 Hargreaves KM, Jackson DL, Bowles WR. Adrenergic regulation of capsaicin-sensitive neurons in dental pulp. Journal of Endodontics. 29: 397-9. PMID 12814223 DOI: 10.1097/00004770-200306000-00004  1
2003 Keiser K, Hargreaves KM. Strategies for managing the endodontic pain patient. The Journal of the Tennessee Dental Association. 83: 24-8. PMID 12800615  1
2003 Hargreaves KM, Bowles WR, Jackson DL. Intrinsic regulation of CGRP release by dental pulp sympathetic fibers. Journal of Dental Research. 82: 398-401. PMID 12709509  1
2003 Bowles WR, Withrow JC, Lepinski AM, Hargreaves KM. Tissue levels of immunoreactive substance P are increased in patients with irreversible pulpitis. Journal of Endodontics. 29: 265-7. PMID 12701777 DOI: 10.1097/00004770-200304000-00009  1
2003 Bowles WR, Flores CM, Jackson DL, Hargreaves KM. beta 2-Adrenoceptor regulation of CGRP release from capsaicin-sensitive neurons. Journal of Dental Research. 82: 308-11. PMID 12651937  1
2003 Hargreaves KM. A new beginning Journal of Endodontics. 29: 169. DOI: 10.1097/00004770-200303000-00001  1
2002 Hargreaves KM, Keiser K. Development of new pain management strategies. Journal of Dental Education. 66: 113-21. PMID 12358098  1
2001 Hargreaves KM. Spring Pain Conference. May 7-12, 2000. Grand Cayman Island. Journal of Orofacial Pain. 15: 72-3. PMID 11889651  1
2001 Lazarski MP, Walker WA, Flores CM, Schindler WG, Hargreaves KM. Epidemiological evaluation of the outcomes of nonsurgical root canal treatment in a large cohort of insured dental patients. Journal of Endodontics. 27: 791-6. PMID 11771594 DOI: 10.1097/00004770-200112000-00021  1
2001 Flores CM, Leong AS, Dussor GO, Harding-Rose C, Hargreaves KM, Kilo S. Capsaicin-evoked CGRP release from rat buccal mucosa: development of a model system for studying trigeminal mechanisms of neurogenic inflammation. The European Journal of Neuroscience. 14: 1113-20. PMID 11683903 DOI: 10.1046/j.0953-816X.2001.01736.x  1
2001 Wurm C, Richardson JD, Bowles W, Hargreaves KM. Evaluation of functional GABA(B) receptors in dental pulp. Journal of Endodontics. 27: 620-3. PMID 11592491  1
2001 Dionne RA, Lepinski AM, Gordon SM, Jaber L, Brahim JS, Hargreaves KM. Analgesic effects of peripherally administered opioids in clinical models of acute and chronic inflammation. Clinical Pharmacology and Therapeutics. 70: 66-73. PMID 11452246 DOI: 10.1067/mcp.2001.116443  1
2001 Hargreaves KM. The promises and pitfalls of polymorphisms and pain. Journal of Orofacial Pain. 15: 89-90. PMID 11443829  1
2001 Ulrich-Lai YM, Flores CM, Harding-Rose CA, Goodis HE, Hargreaves KM. Capsaicin-evoked release of immunoreactive calcitonin gene-related peptide from rat trigeminal ganglion: evidence for intraganglionic neurotransmission. Pain. 91: 219-26. PMID 11275377 DOI: 10.1016/S0304-3959(00)00439-5  1
2000 Lepinski AM, Hargreaves KM, Goodis HE, Bowles WR. Bradykinin levels in dental pulp by microdialysis. Journal of Endodontics. 26: 744-7. PMID 11471646 DOI: 10.1097/00004770-200012000-00020  1
2000 Lenton SR, Hargreaves KM. Should we conduct a trial of distributing naloxone to heroin users for peer administration to prevent fatal overdose? The Medical Journal of Australia. 173: 260-3. PMID 11130352  1
2000 Goodis HE, Bowles WR, Hargreaves KM. Prostaglandin E2 enhances bradykinin-evoked iCGRP release in bovine dental pulp. Journal of Dental Research. 79: 1604-7. PMID 11023282  1
2000 Kehl LJ, Trempe TM, Hargreaves KM. A new animal model for assessing mechanisms and management of muscle hyperalgesia. Pain. 85: 333-43. PMID 10781907 DOI: 10.1016/S0304-3959(99)00282-1  1
1999 Buck S, Reese K, Hargreaves KM. Pulpal exposure alters neuropeptide levels in inflamed dental pulp and trigeminal ganglia: evaluation of axonal transport. Journal of Endodontics. 25: 718-21. PMID 10726536 DOI: 10.1016/S0099-2399(99)80116-2  1
1999 Doroschak AM, Bowles WR, Hargreaves KM. Evaluation of the combination of flurbiprofen and tramadol for management of endodontic pain. Journal of Endodontics. 25: 660-3. PMID 10687523 DOI: 10.1016/S0099-2399(99)80350-1  1
1999 Garry MG, Jackson DL, Geier HE, Southam M, Hargreaves KM. Evaluation of the efficacy of a bioerodible bupivacaine polymer system on antinociception and inflammatory mediator release. Pain. 82: 49-55. PMID 10422659 DOI: 10.1016/S0304-3959(99)00032-9  1
1999 Pihlstrom BL, Hargreaves KM, Bouwsma OJ, Myers WR, Goodale MB, Doyle MJ. Pain after periodontal scaling and root planing. Journal of the American Dental Association (1939). 130: 801-7. PMID 10377637  1
1999 Jackson DL, Hargreaves KM. Activation of excitatory amino acid receptors in bovine dental pulp evokes the release of iCGRP. Journal of Dental Research. 78: 54-60. PMID 10065946  1
1998 Bunczak-Reeh MA, Hargreaves KM. Effect of inflammation on the delivery of drugs to dental pulp. Journal of Endodontics. 24: 822-5. PMID 10023262 DOI: 10.1016/S0099-2399(98)80010-1  1
1998 Ulrich YM, Hargreaves KM, Harding-Rose CA, Bowles WR, Engeland WC. Characterization of iCGRP release from adrenal capsule primary afferent neurons. Endocrine Research. 24: 777-8. PMID 9888577  1
1998 Hargreaves KM. Case 5. Refractory toothache. Journal of Endodontics. 24: 699-702. PMID 9855816  1
1998 Vulchanova L, Riedl MS, Shuster SJ, Stone LS, Hargreaves KM, Buell G, Surprenant A, North RA, Elde R. P2X3 is expressed by DRG neurons that terminate in inner lamina II. The European Journal of Neuroscience. 10: 3470-8. PMID 9824460 DOI: 10.1046/j.1460-9568.1998.00355.x  1
1998 Swift JQ, Roszkowski MT, Alton T, Hargreaves KM. Effect of intra-articular versus systemic anti-inflammatory drugs in a rabbit model of temporomandibular joint inflammation. Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons. 56: 1288-95; discussion . PMID 9820217  1
1998 Richardson JD, Aanonsen L, Hargreaves KM. Antihyperalgesic effects of spinal cannabinoids. European Journal of Pharmacology. 345: 145-53. PMID 9600630 DOI: 10.1016/S0014-2999(97)01621-X  1
1998 Richardson JD, Kilo S, Hargreaves KM. Cannabinoids reduce hyperalgesia and inflammation via interaction with peripheral CB1 receptors. Pain. 75: 111-9. PMID 9539680 DOI: 10.1016/S0304-3959(97)00213-3  1
1998 Richardson JD, Aanonsen L, Hargreaves KM. Hypoactivity of the spinal cannabinoid system results in NMDA-dependent hyperalgesia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 451-7. PMID 9412521  1
1997 Roszkowski MT, Swift JQ, Hargreaves KM. Effect of NSAID administration on tissue levels of immunoreactive prostaglandin E2, leukotriene B4, and (S)-flurbiprofen following extraction of impacted third molars. Pain. 73: 339-45. PMID 9469523 DOI: 10.1016/S0304-3959(97)00120-6  1
1997 Kilo S, Harding-Rose C, Hargreaves KM, Flores CM. Peripheral CGRP release as a marker for neurogenic inflammation: a model system for the study of neuropeptide secretion in rat paw skin. Pain. 73: 201-7. PMID 9415506 DOI: 10.1016/S0304-3959(97)00108-5  1
1997 Ulrich YM, Hargreaves KM, Flores CM. A comparison of multiple injections versus continuous infusion of nicotine for producing up-regulation of neuronal [3H]-epibatidine binding sites. Neuropharmacology. 36: 1119-25. PMID 9294978 DOI: 10.1016/S0028-3908(97)00107-X  1
1997 Troullos E, Hargreaves KM, Dionne RA. Ibuprofen elevates immunoreactive beta-endorphin levels in humans during surgical stress. Clinical Pharmacology and Therapeutics. 62: 74-81. PMID 9246021 DOI: 10.1016/S0009-9236(97)90153-3  1
1997 Cook SP, Vulchanova L, Hargreaves KM, Elde R, McCleskey EW. Distinct ATP receptors on pain-sensing and stretch-sensing neurons. Nature. 387: 505-8. PMID 9168113 DOI: 10.1038/387505a0  1
1997 Richardson JD, Aanonsen L, Hargreaves KM. SR 141716A, a cannabinoid receptor antagonist, produces hyperalgesia in untreated mice. European Journal of Pharmacology. 319: R3-4. PMID 9042616 DOI: 10.1016/S0014-2999(96)00952-1  1
1996 O'Brien TP, Roszkowski MT, Wolff LF, Hinrichs JE, Hargreaves KM. Effect of a non-steroidal anti-inflammatory drug on tissue levels of immunoreactive prostaglandin E2, immunoreactive leukotriene, and pain after periodontal surgery. Journal of Periodontology. 67: 1307-16. PMID 8997678 DOI: 10.1902/jop.1996.67.12.1307  1
1996 Flores CM, DeCamp RM, Kilo S, Rogers SW, Hargreaves KM. Neuronal nicotinic receptor expression in sensory neurons of the rat trigeminal ganglion: demonstration of alpha3beta4, a novel subtype in the mammalian nervous system. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 7892-901. PMID 8987817  1
1996 Penniston SG, Hargreaves KM. Evaluation of periapical injection of Ketorolac for management of endodontic pain. Journal of Endodontics. 22: 55-9. PMID 8935018 DOI: 10.1016/S0099-2399(96)80272-X  1
1995 Reese K, Buck S, Onorati F, Hargreaves KM. Evaluation of novel opioid analgesics. Northwest Dentistry. 74: 27-8, 68. PMID 9462090  1
1995 Seybold VS, Galeazza MT, Garry MG, Hargreaves KM. Plasticity of calcitonin gene related peptide neurotransmission in the spinal cord during peripheral inflammation. Canadian Journal of Physiology and Pharmacology. 73: 1007-14. PMID 8846392 DOI: 10.1139/y95-141  1
1995 Jackson DL, Graff CB, Richardson JD, Hargreaves KM. Glutamate participates in the peripheral modulation of thermal hyperalgesia in rats. European Journal of Pharmacology. 284: 321-5. PMID 8666015 DOI: 10.1016/0014-2999(95)00449-U  1
1995 Page ML, Hargreaves KM, ElDeeb M. Comparison of concentric condensation technique with laterally condensed gutta-percha. Journal of Endodontics. 21: 308-13. PMID 7673839 DOI: 10.1016/S0099-2399(06)81007-1  1
1995 Swift JQ, Jenny JE, Hargreaves KM. Heat generation in hydroxyapatite-coated implants as a result of CO2 laser application. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics. 79: 410-5. PMID 7614197 DOI: 10.1016/S1079-2104(05)80119-2  1
1995 Bacsik CJ, Swift JQ, Hargreaves KM. Toxic systemic reactions of bupivacaine and etidocaine. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics. 79: 18-23. PMID 7614153 DOI: 10.1016/S1079-2104(05)80067-8  1
1995 Galeazza MT, Garry MG, Yost HJ, Strait KA, Hargreaves KM, Seybold VS. Plasticity in the synthesis and storage of substance P and calcitonin gene-related peptide in primary afferent neurons during peripheral inflammation. Neuroscience. 66: 443-58. PMID 7477885 DOI: 10.1016/0306-4522(94)00545-G  1
1994 Dybdal NO, Hargreaves KM, Madigan JE, Gribble DH, Kennedy PC, Stabenfeldt GH. Diagnostic testing for pituitary pars intermedia dysfunction in horses. Journal of the American Veterinary Medical Association. 204: 627-32. PMID 8163420  1
1994 Dionne RA, Snyder J, Hargreaves KM. Analgesic efficacy of flurbiprofen in comparison with acetaminophen, acetaminophen plus codeine, and placebo after impacted third molar removal. Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons. 52: 919-24; discussion 2. PMID 8064454  1
1994 Garry MG, Richardson JD, Hargreaves KM. Carrageenan-induced inflammation alters the content of i-cGMP and i-cAMP in the dorsal horn of the spinal cord. Brain Research. 646: 135-9. PMID 8055330 DOI: 10.1016/0006-8993(94)90066-3  1
1994 Garry MG, Abraham E, Hargreaves KM, Aanonsen LM. Intrathecal injection of cell-permeable analogs of cyclic 3',5'-guanosine monophosphate produces hyperalgesia in mice. European Journal of Pharmacology. 260: 129-31. PMID 7988635 DOI: 10.1016/0014-2999(94)90328-X  1
1994 Hargreaves KM, Swift JQ, Roszkowski MT, Bowles W, Garry MG, Jackson DL. Pharmacology of peripheral neuropeptide and inflammatory mediator release. Oral Surgery, Oral Medicine, and Oral Pathology. 78: 503-10. PMID 7528373 DOI: 10.1016/0030-4220(94)90045-0  1
1994 Garry MG, Richardson JD, Hargreaves KM. Sodium nitroprusside evokes the release of immunoreactive calcitonin gene-related peptide and substance P from dorsal horn slices via nitric oxide-dependent and nitric oxide-independent mechanisms. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 4329-37. PMID 7517995  1
1993 Kaufman E, Hargreaves KM, Dionne RA. Comparison of oral triazolam and nitrous oxide with placebo and intravenous diazepam for outpatient premedication. Oral Surgery, Oral Medicine, and Oral Pathology. 75: 156-64. PMID 8426714 DOI: 10.1016/0030-4220(93)90086-J  1
1993 Swift JQ, Garry MG, Roszkowski MT, Hargreaves KM. Effect of flurbiprofen on tissue levels of immunoreactive bradykinin and acute postoperative pain. Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons. 51: 112-6; discussion 11. PMID 8426248  1
1993 Hargreaves KM, Roszkowski MT, Swift JQ. Bradykinin and inflammatory pain. Agents and Actions. Supplements. 41: 65-73. PMID 8317343  1
1993 Swift JQ, Hargreaves KM. Pentazocine analgesia: is there a niche for Talwin Nx? Compendium (Newtown, Pa.). 14: 1048, 1050 passim; q. PMID 8269439  1
1992 Garry MG, Hargreaves KM. Enhanced release of immunoreactive CGRP and substance P from spinal dorsal horn slices occurs during carrageenan inflammation. Brain Research. 582: 139-42. PMID 1379871 DOI: 10.1016/0006-8993(92)90328-7  1
1992 Hargreaves KM, Bowles WR, Garry MG. An in vitro method to evaluate regulation of neuropeptide release from dental pulp. Journal of Endodontics. 18: 597-600. PMID 1284348 DOI: 10.1016/S0099-2399(06)81329-4  1
1992 Grutzner EH, Garry MG, Hargreaves KM. Effect of injury on pulpal levels of immunoreactive substance P and immunoreactive calcitonin gene-related peptide. Journal of Endodontics. 18: 553-7. PMID 1284347 DOI: 10.1016/S0099-2399(06)81213-6  1
1991 Hargreaves KM, Swift JQ. Mechanisms and management of pain due to inflammation. Northwest Dentistry. 70: 47-9. PMID 1861969  1
1990 Troullos ES, Hargreaves KM, Butler DP, Dionne RA. Comparison of nonsteroidal anti-inflammatory drugs, ibuprofen and flurbiprofen, with methylprednisolone and placebo for acute pain, swelling, and trismus. Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons. 48: 945-52. PMID 2395047 DOI: 10.1016/0278-2391(90)90007-O  1
1990 Hargreaves KM, Costello A. Glucocorticoids suppress levels of immunoreactive bradykinin in inflamed tissue as evaluated by microdialysis probes. Clinical Pharmacology and Therapeutics. 48: 168-78. PMID 2379387  1
1990 Joris J, Costello A, Dubner R, Hargreaves KM. Opiates suppress carrageenan-induced edema and hyperthermia at doses that inhibit hyperalgesia. Pain. 43: 95-103. PMID 2277720 DOI: 10.1016/0304-3959(90)90054-H  1
1990 Flores CM, Hernandez MC, Hargreaves KM, Bayer BM. Restraint stress-induced elevations in plasma corticosterone and beta-endorphin are not accompanied by alterations in immune function. Journal of Neuroimmunology. 28: 219-25. PMID 2142692 DOI: 10.1016/0165-5728(90)90015-F  1
1990 Hargreaves KM, Flores CM, Dionne RA, Mueller GP. The role of pituitary beta-endorphin in mediating corticotropin-releasing factor-induced antinociception. The American Journal of Physiology. 258: E235-42. PMID 2137676  1
1990 Hargreaves KM. Neuroendocrine markers of stress. Anesthesia Progress. 37: 99-105. PMID 2085206  1
1989 Jackson DL, Moore PA, Hargreaves KM. Preoperative nonsteroidal anti-inflammatory medication for the prevention of postoperative dental pain. Journal of the American Dental Association (1939). 119: 641-7. PMID 2691542  1
1989 Lavigne GJ, Hargreaves KM, Schmidt EA, Dionne RA. Proglumide potentiates morphine analgesia for acute postsurgical pain. Clinical Pharmacology and Therapeutics. 45: 666-73. PMID 2659236  1
1989 Hargreaves KM, Dubner R, Costello AH. Corticotropin releasing factor (CRF) has a peripheral site of action for antinociception. European Journal of Pharmacology. 170: 275-9. PMID 2620699 DOI: 10.1016/0014-2999(89)90550-5  1
1989 Troullos ES, Hargreaves KM, Goldstein DS, Stull R, Dionne RA. Epinephrine suppresses stress-induced increases in plasma immunoreactive beta-endorphin in humans. The Journal of Clinical Endocrinology and Metabolism. 69: 546-51. PMID 2527244 DOI: 10.1210/jcem-69-3-546  1
1989 Hargreaves KM, Costello AH, Joris JL. Release from inflamed tissue of a substance with properties similar to corticotropin-releasing factor. Neuroendocrinology. 49: 476-82. PMID 2524675 DOI: 10.1159/000125155  1
1989 Dubner R, Hargreaves KM. The neurobiology of pain and its modulation. The Clinical Journal of Pain. 5: S1-4; discussion S4-. PMID 2520436  1
1989 Costello AH, Hargreaves KM. Suppression of carrageenan-induced hyperalgesia, hyperthermia and edema by a bradykinin antagonist. European Journal of Pharmacology. 171: 259-63. PMID 2482813 DOI: 10.1016/0014-2999(89)90118-0  1
1988 Hargreaves KM, Troullos ES, Dionne RA, Schmidt EA, Schafer SC, Joris JL. Bradykinin is increased during acute and chronic inflammation: therapeutic implications. Clinical Pharmacology and Therapeutics. 44: 613-21. PMID 3197362  1
1987 Troullos ES, Goldstein DS, Hargreaves KM, Dionne RA. Plasma epinephrine levels and cardiovascular response to high administered doses of epinephrine contained in local anesthesia. Anesthesia Progress. 34: 10-3. PMID 3472472  1
1987 Hargreaves KM, Troullos ES, Dionne RA. Pharmacologic rationale for the treatment of acute pain. Dental Clinics of North America. 31: 675-94. PMID 3319716  1
1987 Hargreaves KM, Mueller GP, Dubner R, Goldstein D, Dionne RA. Corticotropin-releasing factor (CRF) produces analgesia in humans and rats. Brain Research. 422: 154-7. PMID 3315118 DOI: 10.1016/0006-8993(87)90550-6  1
1987 Hargreaves KM, Schmidt EA, Mueller GP, Dionne RA. Dexamethasone alters plasma levels of beta-endorphin and postoperative pain. Clinical Pharmacology and Therapeutics. 42: 601-7. PMID 2961501  1
1987 Joris JL, Dubner R, Hargreaves KM. Opioid analgesia at peripheral sites: a target for opioids released during stress and inflammation? Anesthesia and Analgesia. 66: 1277-81. PMID 2891323  1
1986 Hargreaves KM, Dionne RA, Mueller GP, Goldstein DS, Dubner R. Naloxone, fentanyl, and diazepam modify plasma beta-endorphin levels during surgery. Clinical Pharmacology and Therapeutics. 40: 165-71. PMID 3731680  1
1984 Dionne RA, Mueller GP, Young RF, Greenberg RP, Hargreaves KM, Gracely R, Dubner R. Contrast medium causes the apparent increase in beta-endorphin levels in human cerebrospinal fluid following brain stimulation. Pain. 20: 313-21. PMID 6097857 DOI: 10.1016/0304-3959(84)90109-X  1
1983 Hargreaves KM, Dionne RA, Mueller GP. Plasma beta-endorphin-like immunoreactivity, pain and anxiety following administration of placebo in oral surgery patients. Journal of Dental Research. 62: 1170-3. PMID 6580319  1
1982 Hargreaves KM, Dionne RA. Endogenous pain pathways: applications to pain control in dental practice. The Compendium of Continuing Education in Dentistry. 3: 161-6. PMID 6954022  1
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