Christopher M. Flores - Related publications

Affiliations: 
University of Minnesota, Twin Cities, Minneapolis, MN 
Area:
pain, nicotine
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50 most relevant papers in past 60 days:
Year Citation  Score
2020 Intagliata S, Sharma A, King TI, Mesangeau C, Seminerio M, Chin FT, Wilson LL, Matsumoto RR, McLaughlin JP, Avery BA, McCurdy CR. Discovery of a Highly Selective Sigma-2 Receptor Ligand, 1-(4-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)butyl)-3-methyl-1H-benzo[d]imidazol-2(3H)-one (CM398), with Drug-Like Properties and Antinociceptive Effects In Vivo. The Aaps Journal. 22: 94. PMID 32691179 DOI: 10.1208/s12248-020-00472-x   
2020 Nguyen T, Marusich J, Li JX, Zhang Y. Neuropeptide FF and Its Receptors: Therapeutic Applications and Ligand Development. Journal of Medicinal Chemistry. PMID 32673481 DOI: 10.1021/acs.jmedchem.0c00643   
2020 Segura-Chama P, Luis E, Almanza A, Pellicer F, Hernández-Cruz A, Mercado F. Modulation of intracellular calcium concentration by D2-like DA receptor agonists in non-peptidergic DRG neurons is mediated mainly by D4 receptor activation. Neuroscience Letters. 135267. PMID 32717335 DOI: 10.1016/j.neulet.2020.135267   
2020 Fujii N, McGarr GW, Ghassa R, Schmidt MD, McCormick JJ, Nishiyasu T, Kenny GP. Sex-differences in cholinergic, nicotinic, and β-adrenergic cutaneous vasodilation: Roles of nitric oxide synthase, cyclooxygenase, and K channels. Microvascular Research. 131: 104030. PMID 32531353 DOI: 10.1016/j.mvr.2020.104030   
2020 Corrie LW, Stokes C, Wilkerson JL, Carroll FI, McMahon LR, Papke RL. Nicotinic Acetylcholine Receptor Accessory Subunits Determine the Activity Profile of Epibatidine Derivatives. Molecular Pharmacology. PMID 32690626 DOI: 10.1124/molpharm.120.000037   
2020 Nieman AN, Li G, Zahn NM, Mian MY, Mikulsky BN, Hoffman DA, Wilcox TM, Kehoe AS, Luecke IW, Poe MM, Alvarez-Carbonell D, Cook JM, Stafford DC, Arnold LA. Targeting nitric oxide production in microglia with novel imidazodiazepines for non-sedative pain treatment. Acs Chemical Neuroscience. PMID 32511908 DOI: 10.1021/acschemneuro.0c00324   
2020 Zheng N, Christensen S, Blakely A, Dowell C, Purushottam L, McIntosh JM, Chou DH. Development of Conformationally Constrained α-RgIA Analogues as Stable Peptide Antagonists of Human α9α10 Nicotinic Acetylcholine Receptors. Journal of Medicinal Chemistry. PMID 32597184 DOI: 10.1021/acs.jmedchem.0c00613   
2020 Johnson K, Yin J, In JG, Kulkarni S, Pasricha P, Tse M, Donowitz M. Cholinergic-induced anion secretion in murine jejunal enteroids involves synergy between muscarinic and nicotinic pathways. American Journal of Physiology. Cell Physiology. PMID 32551856 DOI: 10.1152/ajpcell.00179.2020   
2020 Chiocchetti R, Rinnovati R, Tagliavia C, Stanzani A, Galiazzo G, Giancola F, De Silva M, Capodanno Y, Spadari A. Localisation of cannabinoid and cannabinoid-related receptors in the equine dorsal root ganglia. Equine Veterinary Journal. PMID 32524649 DOI: 10.1111/evj.13305   
2020 Gillet C, Kurth S, Kuenzel T. Muscarinic modulation of M and h currents in gerbil spherical bushy cells. Plos One. 15: e0226954. PMID 31940388 DOI: 10.1371/journal.pone.0226954   
2020 Yuwei W, Dongqin F, Qiaofen G, Li Y, Qian Z, Han J, Liu Z, Ren W, Liu Y. Activation of CB1 receptors on GABAergic interneurons in the ventrolateral orbital cortex induces analgesia. Neuroscience Letters. 135286. PMID 32745558 DOI: 10.1016/j.neulet.2020.135286   
2020 Gelfuso EA, Reis SL, Aguiar DSR, Faggion SA, Gomes FMM, Galan DT, Peigneur S, Pereira AMS, Mortari MR, Cunha AOS, Tytgat J, Beleboni RO. New insights in the mode of action of (+)-erythravine and (+)-11α-hydroxy-erythravine alkaloids. European Journal of Pharmacology. 173390. PMID 32735983 DOI: 10.1016/j.ejphar.2020.173390   
2020 Mugnaini C, Kostrzewa M, Bryk M, Mahmoud AM, Brizzi A, Lamponi S, Giorgi G, Ferlenghi F, Vacondio F, Maccioni P, Colombo G, Mor M, Starowicz K, Di Marzo V, Ligresti A, et al. Design, Synthesis, and Physicochemical and Pharmacological Profiling of 7-Hydroxy-5-oxopyrazolo[4,3-]pyridine-6-carboxamide Derivatives with Antiosteoarthritic Activity In Vivo. Journal of Medicinal Chemistry. PMID 32515588 DOI: 10.1021/acs.jmedchem.0c00595   
2020 Stoveken HM, Zucca S, Masuho I, Grill B, Martemyanov KA. The orphan receptor GPR139 signals via Gq/11 to oppose opioid effects. The Journal of Biological Chemistry. PMID 32576659 DOI: 10.1074/jbc.AC120.014770   
2020 Gallagher CI, Sheipouri D, Shimmon S, Rawling T, Vandenberg RJ. Identification of N-acyl amino acids that are positive allosteric modulators of glycine receptors. Biochemical Pharmacology. 114117. PMID 32579961 DOI: 10.1016/j.bcp.2020.114117   
2020 Bucknell SJ, Ator MA, Brown A, Brown J, Cansfield A, Cansfield J, Christopher J, Congreve M, Cseke G, Deflorian F, Jones C, Mason JS, O'Brien A, Ott GR, Pickworth M, et al. Structure-Based Drug Discovery of N-((R)-3-(7-Methyl-1H-indazol-5-yl)-1-oxo-1-(((S)-1-oxo-3-(piperidin-4-yl)-1-(4-(pyridin-4-yl)piperazin-1-yl)propan-2-yl)amino)propan-2-yl)-2'-oxo-1',2'-dihydrospiro[piperidine-4,4'-pyrido[2,3-d][1,3]oxazine]-1-carboxamide (HTL22562): a Calcitonin Gene-Related Peptide (CGRP) Receptor Antagonist For Acute Treatment of Migraine. Journal of Medicinal Chemistry. PMID 32558564 DOI: 10.1021/acs.jmedchem.0c01003   
2020 Wu J, Li X, Zhou P, Li X. M but not M muscarinic receptors in the rostromedial tegmental nucleus are involved in the acquisition of morphine-induced conditioned place preference. European Journal of Pharmacology. 173274. PMID 32534071 DOI: 10.1016/j.ejphar.2020.173274   
2020 Huynh PN, Harvey PJ, Gajewiak J, Craik DJ, Michael McIntosh J. Critical residue properties for potency and selectivity of α-Conotoxin RgIA towards α9α10 nicotinic acetylcholine receptors. Biochemical Pharmacology. 114124. PMID 32593612 DOI: 10.1016/j.bcp.2020.114124   
2020 Domocos D, Selescu T, Ceafalan LC, Iodi Carstens M, Carstens E, Babes A. Role of 5-HT1A and 5-HT3 receptors in serotonergic activation of sensory neurons in relation to itch and pain behavior in the rat. Journal of Neuroscience Research. PMID 32537854 DOI: 10.1002/jnr.24633   
2020 Soeberdt M, Kilic A, Abels C. Small molecule drugs for the treatment of pruritus in patients with atopic dermatitis. European Journal of Pharmacology. 173242. PMID 32504692 DOI: 10.1016/j.ejphar.2020.173242   
2020 Besserer-Offroy É, Tétreault P, Brouillette RL, René A, Murza A, Fanelli R, Kirby K, Parent A, Dubuc I, Beaudet N, Côté J, Longpré JM, Martinez J, Cavelier F, Sarret P. Data set describing the biological activity of JMV2009, a novel silylated neurotensin(8-13) analog. Data in Brief. 31: 105884. PMID 32637491 DOI: 10.1016/j.dib.2020.105884   
2020 Wu X, Li JY, Lee A, Lu YX, Zhou SY, Owyang C. Satiety induced by bile acids is mediated via vagal afferent pathways. Jci Insight. 5. PMID 32699194 DOI: 10.1172/jci.insight.132400   
2020 Xu B, Xiao J, Xu K, Zhang Q, Chen D, Zhang R, Zhang M, Zhu H, Niu J, Zheng T, Li N, Zhang X, Fang Q. VF-13, a chimeric peptide of VD-hemopressin(α) and neuropeptide VF, produces potent antinociception with reduced cannabinoid-related side effects. Neuropharmacology. 108178. PMID 32544481 DOI: 10.1016/j.neuropharm.2020.108178   
2020 Yang X, Dilweg MA, Osemwengie D, Burggraaff L, van der Es D, Heitman LH, IJzerman AP. Design and Pharmacological Profile of a Novel Covalent Partial Agonist for the Adenosine A Receptor. Biochemical Pharmacology. 114144. PMID 32653590 DOI: 10.1016/j.bcp.2020.114144   
2020 Currò D, Navarra P, Samengo I, Martire M. P2X7 receptors exert a permissive effect on the activation of presynaptic AMPA receptors in rat trigeminal caudal nucleus glutamatergic nerve terminals. The Journal of Headache and Pain. 21: 83. PMID 32615921 DOI: 10.1186/s10194-020-01153-y   
2020 Mitra S, Khatri SN, Maulik M, Bult-Ito A, Schulte M. Allosterism of Nicotinic Acetylcholine Receptors: Therapeutic Potential for Neuroinflammation Underlying Brain Trauma and Degenerative Disorders. International Journal of Molecular Sciences. 21. PMID 32664647 DOI: 10.3390/ijms21144918   
2020 Marcovich I, Moglie MJ, Carpaneto Freixas AE, Trigila AP, Franchini LF, Plazas PV, Lipovsek M, Elgoyhen AB. Distinct Evolutionary Trajectories of Neuronal and Hair Cell Nicotinic Acetylcholine Receptors. Molecular Biology and Evolution. 37: 1070-1089. PMID 31821508 DOI: 10.1093/molbev/msz290   
2020 Leino T, Lehtimäki J, Koivisto A, Haapalinna A, Pesonen U. Fadolmidine - Favourable adverse effects profile for spinal analgesia suggested by in vitro and in vivo models. European Journal of Pharmacology. 173296. PMID 32592769 DOI: 10.1016/j.ejphar.2020.173296   
2020 Anwar T, Nadeem H, Sarwar S, Naureen H, Ahmed S, Khan A, Arif M. Investigation of antioxidant and anti-nociceptive potential of isoxazolone, pyrazolone derivatives, and their molecular docking studies. Drug Development Research. PMID 32662202 DOI: 10.1002/ddr.21711   
2020 Rufener L, Kaur K, Sarr A, Aaen SM, Horsberg TE. Nicotinic acetylcholine receptors: Ex-vivo expression of functional, non-hybrid, heteropentameric receptors from a marine arthropod, Lepeophtheirus salmonis. Plos Pathogens. 16: e1008715. PMID 32716968 DOI: 10.1371/journal.ppat.1008715   
2020 Ghimire M, Cai R, Ling L, Hackett TA, Caspary DM. Nicotinic Receptor Subunit Distribution in Auditory Cortex: Impact of Aging on Receptor Number and Function. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 32541068 DOI: 10.1523/JNEUROSCI.0093-20.2020   
2020 Alsalem M, Aldossary SA, Haddad M, Altarifi A, Kalbouneh H, Azab B, Mustafa AG, Jaffal SM, El-Salem K. The desensitization of the transient receptor potential vanilloid 1 by nonpungent agonists and its resensitization by bradykinin. Neuroreport. 31: 781-786. PMID 32618816 DOI: 10.1097/WNR.0000000000001485   
2020 Choi DS, Ji Y, Jang Y, Lee WJ, Shim WS. Crotamiton, an Anti-Scabies Agent, Suppresses Histamine- and Chloroquine-Induced Itch Pathways in Sensory Neurons and Alleviates Scratching in Mice. Biomolecules & Therapeutics. PMID 32536619 DOI: 10.4062/biomolther.2020.063   
2020 Andoh T, Suzuki K, Konno M, Tsuneyama K, Kuraishi Y. Pharmacological Characterization of a Novel Mouse Model of Cholestatic Pruritus. Biological & Pharmaceutical Bulletin. 43: 1111-1117. PMID 32612073 DOI: 10.1248/bpb.b20-00097   
2020 Brimson JM, Akula KK, Abbas H, Ferry DR, Kulkarni SK, Russell ST, Tisdale MJ, Tencomnao T, Safrany ST. Simple ammonium salts acting on sigma-1 receptors yield potential treatments for cancer and depression. Scientific Reports. 10: 9251. PMID 32514120 DOI: 10.1038/s41598-020-65849-6   
2020 Gharishvandi F, Abdollahi A, Shafaroodi H, Jafari RM, Pasalar P, Dehpour AR. Involvement of 5-HT1B/1D receptors in the inflammatory response and oxidative stress in intestinal ischemia/reperfusion in rats. European Journal of Pharmacology. 173265. PMID 32574671 DOI: 10.1016/j.ejphar.2020.173265   
2020 Hoang JD, Salavatian S, Yamaguchi N, Swid MA, Vaseghi M. Cardiac sympathetic activation circumvents high-dose beta blocker therapy in part through release of neuropeptide Y. Jci Insight. 5. PMID 32493842 DOI: 10.1172/jci.insight.135519   
2020 Nirthanan S. Snake three-finger α-neurotoxins and nicotinic acetylcholine receptors: molecules, mechanisms and medicine. Biochemical Pharmacology. 114168. PMID 32710970 DOI: 10.1016/j.bcp.2020.114168   
2020 Changeux JP. Golden Anniversary of the Nicotinic Receptor. Neuron. 107: 14-16. PMID 32645305 DOI: 10.1016/j.neuron.2020.05.026   
2020 Stenqvist J, Carlsson T, Winder M, Aronsson P. Functional atropine sensitive purinergic responses in the healthy rat bladder. Autonomic Neuroscience : Basic & Clinical. 227: 102693. PMID 32563054 DOI: 10.1016/j.autneu.2020.102693   
2020 Stenqvist J, Aronsson P, Carlsson T, Winder M, Tobin G. In vivo paracrine effects of ATP-induced urothelial acetylcholine in the rat urinary bladder. Autonomic Neuroscience : Basic & Clinical. 227: 102689. PMID 32473532 DOI: 10.1016/j.autneu.2020.102689   
2020 Haranishi Y, Hara K, Terada T. Antihyperalgesic effects of intrathecal perospirone in a rat model of neuropathic pain. Pharmacology, Biochemistry, and Behavior. 172964. PMID 32504731 DOI: 10.1016/j.pbb.2020.172964   
2020 Tian J, He Y, Deuther-Conrad W, Fu H, Xie F, Zhang Y, Wang T, Zhang X, Zhang J, Brust P, Huang Y, Jia H. Synthesis and evaluation of new 1-oxa-8-azaspiro[4.5]decane derivatives as candidate radioligands for sigma-1 receptors. Bioorganic & Medicinal Chemistry. 28: 115560. PMID 32616183 DOI: 10.1016/j.bmc.2020.115560   
2020 Bolchi C, Bavo F, Appiani R, Roda G, Pallavicini M. 1,4-Benzodioxane, an evergreen, versatile scaffold in medicinal chemistry: A review of its recent applications in drug design. European Journal of Medicinal Chemistry. 200: 112419. PMID 32502862 DOI: 10.1016/j.ejmech.2020.112419   
2020 Cox S, Sommardahl C, Fortner C, Davis R, Bergman J, Doherty T. Determination of grapiprant plasma and urine concentrations in horses. Veterinary Anaesthesia and Analgesia. PMID 32439238 DOI: 10.1016/j.vaa.2020.04.006   
2020 An D, Peigneur S, Hendrickx LA, Tytgat J. Targeting Cannabinoid Receptors: Current Status and Prospects of Natural Products. International Journal of Molecular Sciences. 21. PMID 32709050 DOI: 10.3390/ijms21145064   
2020 Li X, Shen L, Hua T, Liu ZJ. Structural and Functional Insights into Cannabinoid Receptors. Trends in Pharmacological Sciences. PMID 32739033 DOI: 10.1016/j.tips.2020.06.010   
2020 Song M, Yan R, Zhang Y, Guo D, Zhou N, Deng X. Design, synthesis, and anticonvulsant effects evaluation of nonimidazole histamine H receptor antagonists/inverse agonists containing triazole moiety. Journal of Enzyme Inhibition and Medicinal Chemistry. 35: 1310-1321. PMID 32529860 DOI: 10.1080/14756366.2020.1774573   
2020 Smith B, Rowe J, Watkins PB, Ashina M, Woodhead JL, Sistare FD, Goadsby PJ. Mechanistic Investigations Support Liver Safety of Ubrogepant. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 32579200 DOI: 10.1093/toxsci/kfaa093   
2020 Jiang WN, Jing X, Li M, Deng H, Jiang T, Xiong KZ, Chen Y, Wang XF, Wang QJ. Corydaline and l-tetrahydropalmatine attenuate morphine-induced conditioned place preference and the changes in dopamine D and GluA1 AMPA receptor expression in rats. European Journal of Pharmacology. 173397. PMID 32717192 DOI: 10.1016/j.ejphar.2020.173397