Year |
Citation |
Score |
2023 |
Burguin A, Roy J, Ouellette G, Maltais R, Bherer J, Diorio C, Poirier D, Durocher F. Aminosteroid RM-581 Decreases Cell Proliferation of All Breast Cancer Molecular Subtypes, Alone and in Combination with Breast Cancer Treatments. Journal of Clinical Medicine. 12. PMID 37445276 DOI: 10.3390/jcm12134241 |
0.602 |
|
2023 |
Poirier D, Roy J, Maltais R, Weidmann C, Audet-Walsh É. An Aminosteroid Derivative Shows Higher In Vitro and In Vivo Potencies than Gold Standard Drugs in Androgen-Dependent Prostate Cancer Models. Cancers. 15. PMID 37296995 DOI: 10.3390/cancers15113033 |
0.606 |
|
2023 |
Maltais R, Sancéau JY, Poirier D, Marette A. A Concise, Gram-Scale Total Synthesis of Protectin DX and Related Labeled Versions via a Key Stereoselective Reduction of Enediyne. The Journal of Organic Chemistry. PMID 37172290 DOI: 10.1021/acs.joc.3c00360 |
0.602 |
|
2023 |
Poirier D. Description of Chemical Synthesis, Nuclear Magnetic Resonance Characterization and Biological Activity of Estrane-Based Inhibitors/Activators of Steroidogenesis. Molecules (Basel, Switzerland). 28. PMID 37110733 DOI: 10.3390/molecules28083499 |
0.33 |
|
2023 |
Ngueta AD, Roy J, Maltais R, Poirier D. Chemical Synthesis and Biological Evaluation of 3-Substituted Estrone/Estradiol Derivatives as 17β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors Acting via a Reverse Orientation of the Natural Substrate Estrone. Molecules (Basel, Switzerland). 28. PMID 36677690 DOI: 10.3390/molecules28020632 |
0.705 |
|
2022 |
Poirier D, Maltais R, Rousseau JA, Roy J, Phoenix S, Cortés-Benítez F, Lecomte R. Chemical synthesis of fluorinated and iodinated 17β-HSD3 inhibitors and evaluation for imaging prostate cancer tumors and tissue biodistribution. Bioorganic Chemistry. 129: 106145. PMID 36174444 DOI: 10.1016/j.bioorg.2022.106145 |
0.677 |
|
2022 |
Poirier D, Nyachieo A, Romano A, Roy J, Maltais R, Chai D, Delvoux B, Tomassetti C, Vanhie A. An irreversible inhibitor of 17β-hydroxysteroid dehydrogenase type 1 inhibits estradiol synthesis in human endometriosis lesions and induces regression of the non-human primate endometriosis model. The Journal of Steroid Biochemistry and Molecular Biology. 106136. PMID 35691460 DOI: 10.1016/j.jsbmb.2022.106136 |
0.646 |
|
2022 |
Sancéau JY, Bélanger P, Maltais R, Poirier D. An Improved Synthesis of Glucuronide Metabolites of Hindered Phenolic Xenoestrogens. Current Organic Synthesis. PMID 35473530 DOI: 10.2174/1570179419666220426104848 |
0.571 |
|
2021 |
Maltais R, Roy J, Perreault M, Sato S, Lévesque JC, Poirier D. Induction of Endoplasmic Reticulum Stress-Mediated Apoptosis by Aminosteroid RM-581 Efficiently Blocks the Growth of PC-3 Cancer Cells and Tumors Resistant or Not to Docetaxel. International Journal of Molecular Sciences. 22. PMID 34681843 DOI: 10.3390/ijms222011181 |
0.609 |
|
2021 |
Thériault JF, Poirier D, Lin SX. The multi-specific human 17 beta-hydroxysteroid dehydrogenase type 7: Non-competitive inhibitors can target different catalyses to facilitate breast cancer treatment. The Journal of Steroid Biochemistry and Molecular Biology. 105963. PMID 34400276 DOI: 10.1016/j.jsbmb.2021.105963 |
0.31 |
|
2021 |
Maltais R, Roy J, Poirier D. Turning a Quinoline-based Steroidal Anticancer Agent into Fluorescent Dye for its Tracking by Cell Imaging. Acs Medicinal Chemistry Letters. 12: 822-826. PMID 34055232 DOI: 10.1021/acsmedchemlett.1c00111 |
0.613 |
|
2021 |
Lespérance M, Roy J, Djiemeny Ngueta A, Maltais R, Poirier D. Synthesis of 16β-derivatives of 3-(2-bromoethyl)-estra-1,3,5(10)-trien-17β-ol as inhibitors of 17β-HSD1 and/or steroid sulfatase for the treatment of estrogen-dependent diseases. Steroids. 108856. PMID 33945801 DOI: 10.1016/j.steroids.2021.108856 |
0.715 |
|
2021 |
Poirier D, Roy J, Maltais R. A Targeted-Covalent Inhibitor of 17β-HSD1 Blocks Two Estrogen-Biosynthesis Pathways: In Vitro (Metabolism) and In Vivo (Xenograft) Studies in T-47D Breast Cancer Models. Cancers. 13. PMID 33924352 DOI: 10.3390/cancers13081841 |
0.68 |
|
2021 |
Cortés-Benítez F, Roy J, Perreault M, Maltais R, Poirier D. 16-Picolyl-androsterone derivative exhibits potent 17β-HSD3 inhibitory activity, improved metabolic stability and cytotoxic effect on various cancer cells: Synthesis, homology modeling and docking studies. The Journal of Steroid Biochemistry and Molecular Biology. 105846. PMID 33609690 DOI: 10.1016/j.jsbmb.2021.105846 |
0.692 |
|
2020 |
Boutin S, Maltais R, Roy J, Poirier D. Synthesis of 17β-hydroxysteroid dehydrogenase type 10 steroidal inhibitors: Selectivity, metabolic stability and enhanced potency. European Journal of Medicinal Chemistry. 112909. PMID 33081987 DOI: 10.1016/j.ejmech.2020.112909 |
0.699 |
|
2020 |
Maltais R, Ngueta Djiemeny A, Roy J, Barbeau X, Lambert JP, Poirier D. Design and synthesis of dansyl-labeled inhibitors of steroid sulfatase for optical imaging. Bioorganic & Medicinal Chemistry. 115368. PMID 32122754 DOI: 10.1016/J.Bmc.2020.115368 |
0.695 |
|
2020 |
Stephen P, Roy J, Maltais R, Poirier D. Insight into the Mechanism of 17β-Hydroxysteroid Dehydrogenase Type 3 Inhibition by the Androsterone Derivative RM-532-105 Current Enzyme Inhibition. 16: 243-250. DOI: 10.2174/1573408016999200729110245 |
0.712 |
|
2020 |
Darveau P, Maltais R, Roy J, Poirier D, Morin J. Synthesis and pharmacokinetic study of poly(ethylene oxide) triazole dendrimers decorated with aminosteroids as anticancer agent Journal of Polymer Science. 58: 654-661. DOI: 10.1002/Pol.20190042 |
0.619 |
|
2019 |
Maltais R, Perreault M, Roy J, Poirier D. Minor chemical modifications of the aminosteroid derivative RM-581 lead to major impact on its anticancer activity, metabolic stability and aqueous solubility. European Journal of Medicinal Chemistry. 188: 111990. PMID 31893547 DOI: 10.1016/J.Ejmech.2019.111990 |
0.678 |
|
2019 |
Ferrante T, Adinolfi S, D'Arrigo G, Poirier D, Daga M, Lolli ML, Balliano G, Spyrakis F, Oliaro-Bosso S. Multiple catalytic activities of human 17β-hydroxysteroid dehydrogenase type 7 respond differently to inhibitors. Biochimie. PMID 31887335 DOI: 10.1016/J.Biochi.2019.12.012 |
0.433 |
|
2019 |
Boutin S, Roy J, Maltais R, Poirier D. Formation of 5α-dihydrotestosterone from 5α-androstane-3α,17β-diol in prostate cancer LAPC-4 cells - Identifying inhibitors of non-classical pathways producing the most potent androgen. Bioorganic & Medicinal Chemistry Letters. 126783. PMID 31753699 DOI: 10.1016/J.Bmcl.2019.126783 |
0.684 |
|
2019 |
Cortés-Benítez F, Roy J, Perreault M, Maltais R, Poirier D. A- and D-ring structural modifications of an androsterone derivative inhibiting 17β-hydroxysteroid dehydrogenase type 3: Chemical synthesis and structure-activity relationships. Journal of Medicinal Chemistry. PMID 31268309 DOI: 10.1021/Acs.Jmedchem.9B00624 |
0.731 |
|
2019 |
Poirier D, Roy J, Maltais R, Ayan D. Antisulfatase, osteogenic and anticancer activities of steroid sulfatase inhibitor EO-33 in mice. Journal of Medicinal Chemistry. PMID 31062594 DOI: 10.1021/Acs.Jmedchem.9B00382 |
0.661 |
|
2019 |
Ghanbari F, Hebert-Losier A, Barry J, Poirier D, Giguere V, Mader S, Philip A. Isolation and functional characterization of a novel endogenous inverse agonist of estrogen related receptors (ERRs) from human pregnancy urine. The Journal of Steroid Biochemistry and Molecular Biology. PMID 30954508 DOI: 10.1016/J.Jsbmb.2019.04.001 |
0.329 |
|
2019 |
Maltais R, Poirier D. Development of a Gram-Scale Synthesis of PBRM, an Irreversible Inhibitor of 17β-Hydroxysteroid Dehydrogenase Type 1 Organic Process Research & Development. 23: 2323-2335. DOI: 10.1021/Acs.Oprd.8B00402 |
0.698 |
|
2018 |
Sancéau JY, Maltais R, Poirier D, Marette A. Total Synthesis of the Antidiabetic (Type 2) Lipid Mediator Protectin DX/PDX. The Journal of Organic Chemistry. PMID 30586310 DOI: 10.1021/Acs.Joc.8B01973 |
0.647 |
|
2018 |
Boutin S, Roy J, Maltais R, Alata W, Calon F, Poirier D. Identification of steroidal derivatives inhibiting the transformations of allopregnanolone and estradiol by 17β-hydroxysteroid dehydrogenase type 10. Bioorganic & Medicinal Chemistry Letters. PMID 30297283 DOI: 10.1016/J.Bmcl.2018.09.031 |
0.727 |
|
2018 |
Lespérance M, Barbeau X, Roy J, Maltais R, Lagüe P, Poirier D. Chemical Synthesis of C3-oxiranyl/oxiranylmethyl-estrane derivatives targeted by molecular modeling and tested as potential inhibitors of 17β-hydroxysteroid dehydrogenase type 1. Steroids. PMID 30273695 DOI: 10.1016/J.Steroids.2018.09.009 |
0.74 |
|
2018 |
Dutour R, Roy J, Cortés-Benítez F, Maltais R, Poirier D. Targeting Cytochrome P450 (CYP) 1B1 Enzyme with Four Series of A-ring Substituted Estrane Derivatives: Design, Synthesis, Inhibitory Activity and Selectivity. Journal of Medicinal Chemistry. PMID 30216063 DOI: 10.1021/Acs.Jmedchem.8B00907 |
0.7 |
|
2018 |
Li T, Maltais R, Poirier D, Lin SX. Combined Biophysical Chemistry Reveals the Finding of a New Covalent Inhibitor with a Low-Reactive Alkyl Halide. The Journal of Physical Chemistry Letters. PMID 30148957 DOI: 10.1021/acs.jpclett.8b02225 |
0.682 |
|
2018 |
Perreault M, Maltais R, Roy J, Picard S, Popa I, Bertrand N, Poirier D. Induction of endoplasmic reticulum stress by aminosteroid derivative RM-581 leads to tumor regression in PANC-1 xenograft model. Investigational New Drugs. PMID 30062573 DOI: 10.1007/S10637-018-0643-4 |
0.643 |
|
2018 |
Sang X, Han H, Poirier D, Lin SX. Steroid sulfatase inhibition success and limitation in breast cancer clinical assays: an underlying mechanism. The Journal of Steroid Biochemistry and Molecular Biology. PMID 29803725 DOI: 10.1016/J.Jsbmb.2018.05.009 |
0.449 |
|
2018 |
Dutour R, Maltais R, Perreault M, Roy J, Poirier D. Parallel Solid-Phase Synthesis Using a New Diethylsilylacetylenic Linker and Leading to Mestranol Derivatives with Potent Antiproliferative Activities on Multiple Cancer Cell Lines. Anti-Cancer Agents in Medicinal Chemistry. PMID 29521249 DOI: 10.2174/1871520618666180307130158 |
0.66 |
|
2018 |
Boutin S, Poirier D. Structure Confirmation and Evaluation of a Nonsteroidal Inhibitor of 17β-Hydroxysteroid Dehydrogenase Type 10 Magnetochemistry. 4: 32. DOI: 10.3390/Magnetochemistry4030032 |
0.488 |
|
2018 |
Li T, Maltais R, Poirier D, Lin S. Combined Biophysical Chemistry Reveals a New Covalent Inhibitor with a Low-Reactivity Alkyl Halide Journal of Physical Chemistry Letters. 9: 5275-5280. DOI: 10.2210/Pdb6Cge/Pdb |
0.703 |
|
2018 |
Djigoue GB, Poirier D. Introducing Molecular Diversity at the C20-position of Pregnenolone by the Formation of Spiro-2-morpholinones Current Organic Synthesis. 15: 541-551. DOI: 10.2174/1570179414666171107161304 |
0.384 |
|
2017 |
Perreault M, Maltais R, Kenmogne LC, Létourneau D, LeHoux JG, Gobeil S, Poirier D. Implication of STARD5 and cholesterol homeostasis disturbance in the endoplasmic reticulum stress-related response induced by pro-apoptotic aminosteroid RM-133. Pharmacological Research. PMID 29287690 DOI: 10.1016/J.Phrs.2017.12.024 |
0.626 |
|
2017 |
Maltais R, Trottier A, Roy J, Ayan D, Bertrand N, Poirier D. Pharmacokinetic profile of PBRM in rodents, a first selective covalent inhibitor of 17β-HSD1 for breast cancer and endometriosis treatments. The Journal of Steroid Biochemistry and Molecular Biology. PMID 29248731 DOI: 10.1016/J.Jsbmb.2017.12.007 |
0.687 |
|
2017 |
Dutour R, Cortés-Benítez F, Roy J, Poirier D. Structure-Based Design and Synthesis of New Estrane-Pyridine Derivatives as Cytochrome P450 (CYP) 1B1 Inhibitors. Acs Medicinal Chemistry Letters. 8: 1159-1164. PMID 29152048 DOI: 10.1021/Acsmedchemlett.7B00265 |
0.442 |
|
2017 |
Trottier A, Maltais R, Ayan D, Barbeau X, Roy J, Perreault M, Poulin R, Lagüe P, Poirier D. Insight into the mode of action and selectivity of PBRM, a covalent steroidal inhibitor of 17β-hydroxysteroid dehydrogenase type 1. Biochemical Pharmacology. PMID 28800957 DOI: 10.1016/J.Bcp.2017.08.004 |
0.714 |
|
2017 |
Dutour R, Poirier D. Inhibitors of cytochrome P450 (CYP) 1B1. European Journal of Medicinal Chemistry. 135: 296-306. PMID 28458135 DOI: 10.1016/J.Ejmech.2017.04.042 |
0.434 |
|
2017 |
Cortés-Benítez F, Roy J, Maltais R, Poirier D. Impact of androstane A- and D-ring inversion on 17β-hydroxysteroid dehydrogenase type 3 inhibitory activity, androgenic effect and metabolic stability. Bioorganic & Medicinal Chemistry. PMID 28254377 DOI: 10.1016/J.Bmc.2017.02.008 |
0.703 |
|
2017 |
Kenmogne LC, Roy J, Maltais R, Rouleau M, Neveu B, Pouliot F, Poirier D. Investigation of the In Vitro and In Vivo efficiency of RM-532-105, a 17β-hydroxysteroid dehydrogenase type 3 inhibitor, in LAPC-4 prostate cancer cell and tumor models. Plos One. 12: e0171871. PMID 28182747 DOI: 10.1371/Journal.Pone.0171871 |
0.711 |
|
2017 |
Perreault M, Maltais R, Roy J, Dutour R, Poirier D. Design of a Mestranol 2-N-Piperazino-Substituted Derivative Showing Potent and Selective in vitro and in vivo Activities in MCF-7 Breast Cancer Models. Chemmedchem. PMID 28060448 DOI: 10.1002/Cmdc.201600482 |
0.695 |
|
2017 |
Poirier D, Maltais R. NMR-Assisted Structure Elucidation of an Anticancer Steroid-β-Enaminone Derivative Magnetochemistry. 3: 37. DOI: 10.3390/Magnetochemistry3040037 |
0.689 |
|
2016 |
Ayotte C, Sylvestre A, Charlebois A, Poirier D. Detection of 5α-androst-2-en-17-one and variants: Identification of main urinary metabolites in human urine samples by GC-MS and NMR. Drug Testing and Analysis. PMID 27714952 DOI: 10.1002/Dta.2105 |
0.351 |
|
2016 |
Poirier D, Roy J, Cortés-Benítez F, Dutour R. Targeting cytochrome P450 (CYP) 1B1 with steroid derivatives. Bioorganic & Medicinal Chemistry Letters. PMID 27687674 DOI: 10.1016/J.Bmcl.2016.09.046 |
0.392 |
|
2016 |
Perreault M, Maltais R, Dutour R, Poirier D. Explorative study on the anticancer activity, selectivity and metabolic stability of related analogs of aminosteroid RM-133. Steroids. PMID 27553727 DOI: 10.1016/J.Steroids.2016.08.015 |
0.687 |
|
2016 |
Ouellet C, Maltais R, Ouellet É, Barbeau X, Lagüe P, Poirier D. Discovery of a sulfamate-based steroid sulfatase inhibitor with intrinsic selective estrogen receptor modulator properties. European Journal of Medicinal Chemistry. 119: 169-182. PMID 27155470 DOI: 10.1016/J.Ejmech.2016.04.044 |
0.716 |
|
2016 |
Kenmogne LC, Maltais R, Poirier D. Synthesis of a dansyl-labeled inhibitor of 17β-hydroxysteroid dehydrogenase type 3 for optical imaging. Bioorganic & Medicinal Chemistry Letters. 26: 2179-83. PMID 27025340 DOI: 10.1016/J.Bmcl.2016.03.069 |
0.715 |
|
2015 |
Talbot A, Maltais R, Kenmogne LC, Roy J, Poirier D. Solid-phase synthesis of libraries of ethynylated aminosteroid derivatives as potential antileukemic agents. Steroids. PMID 26742630 DOI: 10.1016/J.Steroids.2015.12.019 |
0.691 |
|
2015 |
Kenmogne LC, Ayan D, Roy J, Maltais R, Poirier D. The Aminosteroid Derivative RM-133 Shows In Vitro and In Vivo Antitumor Activity in Human Ovarian and Pancreatic Cancers. Plos One. 10: e0144890. PMID 26660672 DOI: 10.1371/Journal.Pone.0144890 |
0.636 |
|
2015 |
Maltais R, Trottier A, Barbeau X, Lagüe P, Perreault M, Thériault JF, Lin SX, Poirier D. Impact of structural modifications at positions 13, 16 and 17 of 16β-(m-carbamoylbenzyl)-estradiol on 17β-hydroxysteroid dehydrogenase type 1 inhibition and estrogenic activity. The Journal of Steroid Biochemistry and Molecular Biology. PMID 26519987 DOI: 10.1016/J.Jsbmb.2015.10.020 |
0.708 |
|
2015 |
Roy J, Fournier MA, Maltais R, Kenmogne LC, Poirier D. Reprint of "In vitro and in vivo evaluation of a 3β-androsterone derivative as inhibitor of 17β-hydroxysteroid dehydrogenase type 3". The Journal of Steroid Biochemistry and Molecular Biology. 153: 170-8. PMID 26291835 DOI: 10.1016/J.Jsbmb.2015.08.014 |
0.713 |
|
2015 |
Djigoué GB, Kenmogne LC, Roy J, Maltais R, Poirier D. Design, chemical synthesis and biological evaluation of 3-spiromorpholinone/3-spirocarbamate androsterone derivatives as inhibitors of 17β-hydroxysteroid dehydrogenase type 3. Bioorganic & Medicinal Chemistry. 23: 5433-51. PMID 26277760 DOI: 10.1016/J.Bmc.2015.07.049 |
0.741 |
|
2015 |
Mansour MF, Pelletier M, Boulet MM, Mayrand D, Brochu G, Lebel S, Poirier D, Fradette J, Cianflone K, Luu-The V, Tchernof A. Oxidative activity of 17β-hydroxysteroid dehydrogenase on testosterone in male abdominal adipose tissues and cellular localization of 17β-HSD type 2. Molecular and Cellular Endocrinology. PMID 26123590 DOI: 10.1016/J.Mce.2015.06.016 |
0.364 |
|
2015 |
Wang X, Gérard C, Thériault JF, Poirier D, Doillon CJ, Lin SX. Synergistic control of sex hormones by 17β-HSD type 7: a novel target for estrogen-dependent breast cancer. Journal of Molecular Cell Biology. 7: 568-79. PMID 25966904 DOI: 10.1093/Jmcb/Mjv028 |
0.431 |
|
2015 |
Maltais R, Trottier A, Delhomme A, Barbeau X, Lagüe P, Poirier D. Identification of fused 16β,17β-oxazinone-estradiol derivatives as a new family of non-estrogenic 17β-hydroxysteroid dehydrogenase type 1 inhibitors. European Journal of Medicinal Chemistry. 93: 470-80. PMID 25728028 DOI: 10.1016/J.Ejmech.2015.01.059 |
0.715 |
|
2015 |
Poirier D. Recent patents on new steroid agents targeting the steroidogenesis for endocrine cancer treatments. Recent Patents On Endocrine, Metabolic & Immune Drug Discovery. 9: 15-23. PMID 25643356 |
0.308 |
|
2015 |
Ouellet C, Ouellet É, Poirier D. In vitro evaluation of a tetrahydroisoquinoline derivative as a steroid sulfatase inhibitor and a selective estrogen receptor modulator. Investigational New Drugs. 33: 95-103. PMID 25410727 DOI: 10.1007/S10637-014-0187-1 |
0.446 |
|
2015 |
Poirier D, Roy J, Maltais R, Ayan D. A Potent Inhibitor of Steroid Sulfatase (EM-1913) Blocks Tumor Growth in Nude Mice (MCF-7 Xenograft) Current Enzyme Inhibition. 11: 65-73. DOI: 10.2174/157340801101150707124626 |
0.596 |
|
2015 |
Fournier D, Ciobanu L, Poirier D. A Sequential Dual Cleavage of the Arylsulfamate Linker to Provide Both Sulfamate and Phenol Derivatives Chemistry Journal of Moldova. 10: 68-76. DOI: 10.19261/Cjm.2015.10(2).09 |
0.783 |
|
2014 |
Ayan D, Maltais R, Hospital A, Poirier D. Chemical synthesis, cytotoxicity, selectivity and bioavailability of 5α-androstane-3α,17β-diol derivatives. Bioorganic & Medicinal Chemistry. 22: 5847-59. PMID 25300820 DOI: 10.1016/J.Bmc.2014.09.026 |
0.72 |
|
2014 |
Djigoué GB, Maltais R, Poirier D. Development of a simple and efficient solution-phase parallel synthesis of flexible non-steroidal estradiol mimics. Combinatorial Chemistry & High Throughput Screening. 17: 734-44. PMID 25230027 DOI: 10.2174/1386207317666140915125620 |
0.674 |
|
2014 |
Trottier A, Maltais R, Poirier D. Identification of a first enzymatic activator of a 17β-hydroxysteroid dehydrogenase. Acs Chemical Biology. 9: 1668-73. PMID 24910887 DOI: 10.1021/Cb500109E |
0.696 |
|
2014 |
Maltais R, Hospital A, Delhomme A, Roy J, Poirier D. Chemical synthesis, NMR analysis and evaluation on a cancer xenograft model (HL-60) of the aminosteroid derivative RM-133. Steroids. 82: 68-76. PMID 24486462 DOI: 10.1016/J.Steroids.2014.01.008 |
0.675 |
|
2014 |
Roy J, Fournier MA, Maltais R, Kenmogne LC, Poirier D. In vitro and in vivo evaluation of a 3β-androsterone derivative as inhibitor of 17β-hydroxysteroid dehydrogenase type 3. The Journal of Steroid Biochemistry and Molecular Biology. 141: 44-51. PMID 24434282 DOI: 10.1016/j.jsbmb.2013.12.019 |
0.687 |
|
2014 |
Maltais R, Ayan D, Trottier A, Barbeau X, Lagüe P, Bouchard JE, Poirier D. Discovery of a non-estrogenic irreversible inhibitor of 17β-hydroxysteroid dehydrogenase type 1 from 3-substituted-16β-(m-carbamoylbenzyl)-estradiol derivatives. Journal of Medicinal Chemistry. 57: 204-22. PMID 24328103 DOI: 10.1021/Jm401639V |
0.724 |
|
2014 |
Ouellet E, Ayan D, Poirier D. Synthesis and Biological Evaluation of Estradiol-Core Derivatives Bearing a Fused γ-Lactone as Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1 Current Enzyme Inhibition. 10: 39-53. DOI: 10.2174/1573408010666140118002739 |
0.404 |
|
2014 |
Talbot A, Maltais R, Poirier D. Synthesis of an estradiol derivative with an adenosine-phosphate mimic linked at position 16β Current Organic Synthesis. 11: 612-620. DOI: 10.2174/15701794113106660078 |
0.716 |
|
2014 |
Popusoi A, Barba N, Gulea A, Roy J, Poirier D. Substituted 1,3-Phenyl(Pyridyl) Propenones and Derivatives with Thiosemicarbazidic Groups. Structrure – (HL-60) Antileukemia Activity Relationship Chemistry Journal of Moldova. 9: 67-73. DOI: 10.19261/Cjm.2014.09(2).10 |
0.318 |
|
2014 |
Pakhontsu E, Tsapkov VI, Poirier D, Gulya AP. Coordination compounds of copper and nickel with N,N′-[4,4′-(perfluoro-1,4-phenylene)bis(oxy)bis(4,1-phenylene)]-bis[2-(pyridin-2-ylmethylidene)hydrazinecarbothioamide] and its derivatives Russian Journal of General Chemistry. 84: 1198-1201. DOI: 10.1134/S1070363214060231 |
0.336 |
|
2013 |
Djigoué GB, Kenmogne LC, Roy J, Poirier D. Synthesis of 3-spiromorpholinone androsterone derivatives as inhibitors of 17β-hydroxysteroid dehydrogenase type 3. Bioorganic & Medicinal Chemistry Letters. 23: 6360-2. PMID 24144853 DOI: 10.1016/J.Bmcl.2013.09.072 |
0.513 |
|
2013 |
Roy J, Lefebvre J, Maltais R, Poirier D. Inhibition of dehydroepiandosterone sulfate action in androgen-sensitive tissues by EM-1913, an inhibitor of steroid sulfatase Molecular and Cellular Endocrinology. 376: 148-155. PMID 23806558 DOI: 10.1016/J.Mce.2013.06.022 |
0.65 |
|
2013 |
Farhane S, Fournier MA, Poirier D. Chemical synthesis, characterisation and biological evaluation of lactonic-estradiol derivatives as inhibitors of 17β-hydroxysteroid dehydrogenase type 1. The Journal of Steroid Biochemistry and Molecular Biology. 137: 322-31. PMID 23685015 DOI: 10.1016/J.Jsbmb.2013.05.002 |
0.49 |
|
2013 |
Lecka J, Gillerman I, Fausther M, Salem M, Munkonda MN, Brosseau JP, Cadot C, Martín-Satué M, d'Orléans-Juste P, Rousseau E, Poirier D, Künzli B, Fischer B, Sévigny J. 8-BuS-ATP derivatives as specific NTPDase1 inhibitors. British Journal of Pharmacology. 169: 179-96. PMID 23425137 DOI: 10.1111/Bph.12135 |
0.362 |
|
2013 |
Djigoué GB, Ngatcha BT, Roy J, Poirier D. Synthesis of 5α-androstane-17-spiro-δ-lactones with a 3-keto, 3-hydroxy, 3-spirocarbamate or 3-spiromorpholinone as inhibitors of 17β-hydroxysteroid dehydrogenases. Molecules (Basel, Switzerland). 18: 914-33. PMID 23344201 DOI: 10.3390/Molecules18010914 |
0.457 |
|
2013 |
Sneitz N, Vahermo M, Mosorin J, Laakkonen L, Poirier D, Finel M. Regiospecificity and stereospecificity of human UDP-glucuronosyltransferases in the glucuronidation of estriol, 16-epiestriol, 17-epiestriol, and 13-epiestradiol. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 582-91. PMID 23288867 DOI: 10.1124/Dmd.112.049072 |
0.329 |
|
2013 |
Ajeawung NF, Maltais R, Jones C, Poirier D, Kamnasaran D. Viability screen on pediatric low grade glioma cell lines unveils a novel anti-cancer drug of the steroid biosynthesis inhibitor family. Cancer Letters. 330: 96-105. PMID 23201138 DOI: 10.1016/J.Canlet.2012.11.034 |
0.662 |
|
2013 |
Ouellet É, Maltais R, Ouellet C, Poirier D. Investigation of a tetrahydroisoquinoline scaffold as dual-action steroid sulfatase inhibitors generated by parallel solid-phase synthesis Medchemcomm. 4: 681. DOI: 10.1039/C3Md20354A |
0.72 |
|
2012 |
Ayan D, Maltais R, Roy J, Poirier D. A new nonestrogenic steroidal inhibitor of 17β-hydroxysteroid dehydrogenase type I blocks the estrogen-dependent breast cancer tumor growth induced by estrone. Molecular Cancer Therapeutics. 11: 2096-104. PMID 22914440 DOI: 10.1158/1535-7163.Mct-12-0299 |
0.712 |
|
2012 |
Jegham H, Maltais R, Dufour P, Roy J, Poirier D. Solid-phase chemical synthesis and in vitro biological evaluation of novel 2β-piperazino-(20R)-5α-pregnane-3α,20-diol N-derivatives as anti-leukemic agents. Steroids. 77: 1403-18. PMID 22910290 DOI: 10.1016/J.Steroids.2012.07.012 |
0.718 |
|
2012 |
Ayan D, Maltais R, Poirier D. Identification of a 17β-hydroxysteroid dehydrogenase type 10 steroidal inhibitor: a tool to investigate the role of type 10 in Alzheimer's disease and prostate cancer. Chemmedchem. 7: 1181-4. PMID 22674910 DOI: 10.1002/Cmdc.201200129 |
0.659 |
|
2012 |
Talbot A, Maltais R, Poirier D. New diethylsilylacetylenic linker for parallel solid-phase synthesis of libraries of hydroxy acetylenic steroid derivatives with improved metabolic stability. Acs Combinatorial Science. 14: 347-51. PMID 22587990 DOI: 10.1021/Co300034Y |
0.672 |
|
2012 |
Gauthier J, Poirier D, Ayotte C. Characterization of desoxymethyltestosterone main urinary metabolite produced from cultures of human fresh hepatocytes. Steroids. 77: 635-43. PMID 22366110 DOI: 10.1016/J.Steroids.2012.02.008 |
0.381 |
|
2012 |
Jegham H, Maltais R, Roy J, Doillon C, Poirier D. Biological evaluation of a new family of aminosteroids that display a selective toxicity for various malignant cell lines. Anti-Cancer Drugs. 23: 803-14. PMID 22361842 DOI: 10.1097/Cad.0B013E328351Aa8C |
0.658 |
|
2012 |
Jegham H, Roy J, Maltais R, Desnoyers S, Poirier D. A novel aminosteroid of the 5α-androstane-3α,17β-diol family induces cell cycle arrest and apoptosis in human promyelocytic leukemia HL-60 cells. Investigational New Drugs. 30: 176-85. PMID 20890632 DOI: 10.1007/S10637-010-9548-6 |
0.637 |
|
2012 |
Djigoué GB, Maltais R, Ouellet C, Trottier A, Poirier D. Chemical Synthesis and NMR Characterization of Non Steroidal Mimics of an Estradiol Derivative Used as Inhibitor of 17beta-Hydroxysteroid Dehydrogenase Type 1 International Journal of Chemistry. 4. DOI: 10.5539/Ijc.V4N6P75 |
0.728 |
|
2012 |
Poirier D, Ajeawung N, Maltais R, Kamnasaran D. 341 Cytotoxic Screen Unveils a Novel Inhibitor of Low Grade Pediatric Astrocytomas Belonging to a Family of Steroid Inhibitor Compounds European Journal of Cancer. 48: 104. DOI: 10.1016/S0959-8049(12)72139-1 |
0.638 |
|
2012 |
Maltais R, Poirier D. Diversity-oriented synthesis of spiro-and fused azacycles from ketone molecular templates European Journal of Organic Chemistry. 5435-5439. DOI: 10.1002/Ejoc.201200852 |
0.684 |
|
2011 |
Maltais R, Ayan D, Poirier D. Crucial Role of 3-Bromoethyl in Removing the Estrogenic Activity of 17β-HSD1 Inhibitor 16β-(m-Carbamoylbenzyl)estradiol. Acs Medicinal Chemistry Letters. 2: 678-681. PMID 21927646 DOI: 10.1021/Ml200093V |
0.716 |
|
2011 |
Ayan D, Roy J, Maltais R, Poirier D. Impact of estradiol structural modifications (18-methyl and/or 17-hydroxy inversion of configuration) on the in vitro and in vivo estrogenic activity. The Journal of Steroid Biochemistry and Molecular Biology. 127: 324-30. PMID 21827856 DOI: 10.1016/J.Jsbmb.2011.07.009 |
0.702 |
|
2011 |
Ouellet E, Ayan D, Poirier D. Synthesis and preliminary evaluation of a modified estradiol-core bearing a fused γ-lactone as non-estrogenic inhibitor of 17β-hydroxysteroid dehydrogenase type 1. Bioorganic & Medicinal Chemistry Letters. 21: 5510-3. PMID 21782424 DOI: 10.1016/J.Bmcl.2011.06.110 |
0.507 |
|
2011 |
Fournier D, Poirier D. Chemical synthesis and evaluation of 17α-alkylated derivatives of estradiol as inhibitors of steroid sulfatase. European Journal of Medicinal Chemistry. 46: 4227-37. PMID 21782294 DOI: 10.1016/j.ejmech.2011.06.027 |
0.361 |
|
2011 |
Maltais R, Fournier MA, Poirier D. Development of 3-substituted-androsterone derivatives as potent inhibitors of 17β-hydroxysteroid dehydrogenase type 3. Bioorganic & Medicinal Chemistry. 19: 4652-68. PMID 21741247 DOI: 10.1016/J.Bmc.2011.06.003 |
0.748 |
|
2011 |
Maltais R, Poirier D. Steroid sulfatase inhibitors: a review covering the promising 2000-2010 decade. Steroids. 76: 929-48. PMID 21458474 DOI: 10.1016/J.Steroids.2011.03.010 |
0.631 |
|
2011 |
Farhane S, Laplante Y, Poirier D. Chemical synthesis, characterisation and biological evaluation of furanic-estradiol derivatives as inhibitors of 17β-hydroxysteroid dehydrogenase type 1. Medicinal Chemistry (ShāRiqah (United Arab Emirates)). 7: 80-91. PMID 21222612 DOI: 10.2174/157340611794859352 |
0.482 |
|
2011 |
Poirier D. Contribution to the development of inhibitors of 17β-hydroxysteroid dehydrogenase types 1 and 7: key tools for studying and treating estrogen-dependent diseases. The Journal of Steroid Biochemistry and Molecular Biology. 125: 83-94. PMID 21182944 DOI: 10.1016/J.Jsbmb.2010.12.007 |
0.492 |
|
2011 |
Roy J, Maltais R, Jegham H, Poirier D. Libraries of 2β-(N-substituted piperazino)-5α-androstane-3α, 17β-diols: chemical synthesis and cytotoxic effects on human leukemia HL-60 cells and on normal lymphocytes. Molecular Diversity. 15: 317-39. PMID 20827507 DOI: 10.1007/S11030-010-9273-2 |
0.712 |
|
2011 |
Farhane S, Fournier MA, Poirier D. Synthesis and evaluation of amido-deoxyestradiol derivatives as inhibitors of 17β-hydroxysteroid dehydrogenase type 12 Current Enzyme Inhibition. 7: 134-146. DOI: 10.2174/157340811798807614 |
0.524 |
|
2011 |
Farhane S, Fournier M, Maltais R, Poirier D. Convergent stereoselective and efficient synthesis of furanic-steroid derivatives Tetrahedron. 67: 2434-2440. DOI: 10.1016/J.Tet.2011.01.083 |
0.719 |
|
2010 |
Poirier D. 17beta-Hydroxysteroid dehydrogenase inhibitors: a patent review. Expert Opinion On Therapeutic Patents. 20: 1123-45. PMID 20645882 DOI: 10.1517/13543776.2010.505604 |
0.361 |
|
2010 |
Bérubé M, Delagoutte F, Poirier D. Preparation of 6beta-estradiol derivative libraries as bisubstrate inhibitors of 7beta-hydroxysteroid dehydrogenase type using the multidetachable sulfamate linker. Molecules (Basel, Switzerland). 15: 1590-631. PMID 20336003 DOI: 10.3390/Molecules15031590 |
0.404 |
|
2010 |
MALTAIS R, POIRIER D. ChemInform Abstract: A Solution-Phase Combinatorial Parallel Synthesis of 3β-Amido-3α-hydroxy-5α-androstane-17-ones. Cheminform. 29: no-no. DOI: 10.1002/chin.199833234 |
0.629 |
|
2010 |
SAM KM, AUGER S, LUU-THE VAN LV, POIRIER D. ChemInform Abstract: Steroidal Spiro-γ-lactones That Inhibit 17β-Hydroxysteroid Dehydrogenase Activity in Human Placental Microsomes. Cheminform. 27: no-no. DOI: 10.1002/CHIN.199610258 |
0.302 |
|
2009 |
Mazumdar M, Fournier D, Zhu DW, Cadot C, Poirier D, Lin SX. Binary and ternary crystal structure analyses of a novel inhibitor with 17beta-HSD type 1: a lead compound for breast cancer therapy. The Biochemical Journal. 424: 357-66. PMID 19929851 DOI: 10.1042/Bj20091020 |
0.401 |
|
2009 |
Bellavance E, Luu-The V, Poirier D. Potent and selective steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 7, an enzyme that catalyzes the reduction of the key hormones estrone and dihydrotestosterone. Journal of Medicinal Chemistry. 52: 7488-502. PMID 19772289 DOI: 10.1021/Jm900921C |
0.336 |
|
2009 |
Poirier D. Advances in development of inhibitors of 17beta hydroxysteroid dehydrogenases. Anti-Cancer Agents in Medicinal Chemistry. 9: 642-60. PMID 19601747 DOI: 10.2174/187152009788680000 |
0.359 |
|
2009 |
Fournier D, Breuil PA, Poirier D. Synthesis of aryl sulfamate and phenol small peptide derivatives using a multidetachable sulfamate linker strategy. Advances in Experimental Medicine and Biology. 611: 219-20. PMID 19400168 DOI: 10.1007/978-0-387-73657-0_101 |
0.467 |
|
2009 |
Fournier D, Poirier D. Estradiol dimers as a new class of steroid sulfatase reversible inhibitors. Bioorganic & Medicinal Chemistry Letters. 19: 693-6. PMID 19128967 DOI: 10.1016/J.Bmcl.2008.12.047 |
0.368 |
|
2009 |
Gauthier J, Goudreault D, Poirier D, Ayotte C. Identification of drostanolone and 17-methyldrostanolone metabolites produced by cryopreserved human hepatocytes. Steroids. 74: 306-14. PMID 19056412 DOI: 10.1016/J.Steroids.2008.11.002 |
0.316 |
|
2009 |
Bérubé M, Poirier D. Improved synthesis of EM-1745, preparation of its C17-ketone analogue and comparison of their inhibitory potency on 17beta-hydroxysteroid dehydrogenase type 1. Journal of Enzyme Inhibition and Medicinal Chemistry. 24: 832-43. PMID 19003559 DOI: 10.1080/14756360802399761 |
0.408 |
|
2009 |
Fournier MA, Poirier D. Estrogen formation in endometrial and cervix cancer cell lines: involvement of aromatase, steroid sulfatase and 17beta-hydroxysteroid dehydrogenases (types 1, 5, 7 and 12). Molecular and Cellular Endocrinology. 301: 142-5. PMID 18817841 DOI: 10.1016/J.Mce.2008.08.027 |
0.36 |
|
2009 |
Laplante Y, Rancourt C, Poirier D. Relative involvement of three 17beta-hydroxysteroid dehydrogenases (types 1, 7 and 12) in the formation of estradiol in various breast cancer cell lines using selective inhibitors. Molecular and Cellular Endocrinology. 301: 146-53. PMID 18812208 DOI: 10.1016/J.Mce.2008.08.026 |
0.399 |
|
2009 |
Chura JC, Ryu HS, Simard M, Poirier D, Tremblay Y, Brooker DC, Blomquist CH, Argenta PA. Steroid-converting enzymes in human ovarian carcinomas. Molecular and Cellular Endocrinology. 301: 51-8. PMID 18723074 DOI: 10.1016/J.Mce.2008.07.015 |
0.328 |
|
2009 |
Bydal P, Luu-The V, Labrie F, Poirier D. Steroidal lactones as inhibitors of 17beta-hydroxysteroid dehydrogenase type 5: chemical synthesis, enzyme inhibitory activity, and assessment of estrogenic and androgenic activities. European Journal of Medicinal Chemistry. 44: 632-44. PMID 18472187 DOI: 10.1016/J.Ejmech.2008.03.020 |
0.441 |
|
2009 |
Bérubé M, Poirier D. Design, chemical synthesis, and in vitro biological evaluation of simplified estradiol-adenosine hybrids as inhibitors of 17β-hydroxysteroid dehydrogenase type 1 Canadian Journal of Chemistry. 87: 1180-1199. DOI: 10.1139/V09-083 |
0.377 |
|
2009 |
Maltais R, Fournier D, Poirier D. Quantitative structure-activity relationship (QSAR) study with a series of 17α-derivatives of estradiol: Model for the development of reversible steroid sulfatase inhibitors Qsar and Combinatorial Science. 28: 1284-1299. DOI: 10.1002/Qsar.200960028 |
0.7 |
|
2008 |
Thibeault D, Roy J, DeRoy P, Poirier D. Chemical synthesis of 2beta-amino-5alpha-androstane-3alpha,17beta-diol N-derivatives and their antiproliferative effect on HL-60 human leukemia cells. Bioorganic & Medicinal Chemistry. 16: 5062-77. PMID 18375126 DOI: 10.1016/J.Bmc.2008.03.031 |
0.339 |
|
2008 |
Laplante Y, Poirier D. Proliferative effect of androst-4-ene-3,17-dione and its metabolites in the androgen-sensitive LNCaP cell line. Steroids. 73: 266-71. PMID 18082864 DOI: 10.1016/J.Steroids.2007.10.009 |
0.363 |
|
2008 |
Laplante Y, Cadot C, Fournier MA, Poirier D. Estradiol and estrone C-16 derivatives as inhibitors of type 1 17beta-hydroxysteroid dehydrogenase: blocking of ER+ breast cancer cell proliferation induced by estrone. Bioorganic & Medicinal Chemistry. 16: 1849-60. PMID 18035543 DOI: 10.1016/j.bmc.2007.11.007 |
0.316 |
|
2008 |
Rouillard F, Lefebvre J, Fournier M, Poirier D. Chemical Synthesis, 17β-Hydroxysteroid Dehydrogenase Type 1 Inhibitory Activity and Assessment of In Vitro and In Vivo Estrogenic Activities of Estradiol Derivatives The Open Enzyme Inhibition Journal. 1: 61-71. DOI: 10.2174/1874940200801010061 |
0.473 |
|
2008 |
Rouillard F, Roy J, Poirier D. Chemical synthesis of (S)-spiro(estradiol-17,2′-[1,4]oxazinan)- 6′-one derivatives bearing two levels of molecular diversity European Journal of Organic Chemistry. 2446-2453. DOI: 10.1002/Ejoc.200701077 |
0.427 |
|
2008 |
Poirier D. New cancer drugs targeting the biosynthesis of estrogens and androgens Drug Development Research. 69: 304-318. DOI: 10.1002/Ddr.20263 |
0.43 |
|
2007 |
Bérubé M, Poirier D. Chemical synthesis and in vitro biological evaluation of a phosphorylated bisubstrate inhibitor of type 3 17beta-hydroxysteroid dehydrogenase. Journal of Enzyme Inhibition and Medicinal Chemistry. 22: 201-11. PMID 17518347 DOI: 10.1080/14756360601051423 |
0.369 |
|
2007 |
Roy J, DeRoy P, Poirier D. 2beta-(N-substituted piperazino)-5alpha-androstane-3alpha,17beta-diols: parallel solid-phase synthesis and antiproliferative activity on human leukemia HL-60 cells. Journal of Combinatorial Chemistry. 9: 347-58. PMID 17441773 DOI: 10.1021/Cc060098Z |
0.384 |
|
2007 |
Roy J, Breton R, Martel C, Labrie F, Poirier D. Chemical synthesis and biological activities of 16alpha-derivatives of 5alpha-androstane-3alpha,17beta-diol as antiandrogens. Bioorganic & Medicinal Chemistry. 15: 3003-18. PMID 17336533 DOI: 10.1016/J.Bmc.2007.02.007 |
0.338 |
|
2007 |
Cadot C, Laplante Y, Kamal F, Luu-The V, Poirier D. C6-(N,N-butyl-methyl-heptanamide) derivatives of estrone and estradiol as inhibitors of type 1 17beta-hydroxysteroid dehydrogenase: Chemical synthesis and biological evaluation. Bioorganic & Medicinal Chemistry. 15: 714-26. PMID 17110114 DOI: 10.1016/J.Bmc.2006.10.055 |
0.419 |
|
2006 |
Ciobanu LC, Poirier D. Synthesis of libraries of 16beta-aminopropyl estradiol derivatives for targeting two key steroidogenic enzymes. Chemmedchem. 1: 1249-59. PMID 16986200 DOI: 10.1002/Cmdc.200600071 |
0.817 |
|
2006 |
Bérubé M, Laplante Y, Poirier D. Design, synthesis and in vitro evaluation of 4-androstene-3,17-dione/adenosine hybrid compounds as bisubstrate inhibitors of type 3 17beta-hydroxysteroid dehydrogenase. Medicinal Chemistry (ShāRiqah (United Arab Emirates)). 2: 329-47. PMID 16848745 DOI: 10.2174/157340606777724086 |
0.431 |
|
2006 |
Poirier D, Maltais R. Solid-phase organic synthesis (SPOS) of modulators of estrogenic and androgenic action. Mini Reviews in Medicinal Chemistry. 6: 37-52. PMID 16457631 DOI: 10.2174/138955706775197802 |
0.648 |
|
2006 |
Ngatcha BT, Laplante Y, Labrie F, Luu-The V, Poirier D. 3Beta-alkyl-androsterones as inhibitors of type 3 17beta-hydroxysteroid dehydrogenase: inhibitory potency in intact cells, selectivity towards isoforms 1, 2, 5 and 7, binding affinity for steroid receptors, and proliferative/antiproliferative activities on AR+ and ER+ cell lines. Molecular and Cellular Endocrinology. 248: 225-32. PMID 16359782 DOI: 10.1016/J.Mce.2005.10.023 |
0.382 |
|
2006 |
Poirier D, Chang HJ, Azzi A, Boivin RP, Lin SX. Estrone and estradiol C-16 derivatives as inhibitors of type 1 17beta-hydroxysteroid dehydrogenase. Molecular and Cellular Endocrinology. 248: 236-8. PMID 16337735 DOI: 10.1016/J.Mce.2005.10.017 |
0.376 |
|
2005 |
Poirier D, Boivin RP, Tremblay MR, Bérubé M, Qiu W, Lin SX. Estradiol-adenosine hybrid compounds designed to inhibit type 1 17beta-hydroxysteroid dehydrogenase. Journal of Medicinal Chemistry. 48: 8134-47. PMID 16366595 DOI: 10.1021/Jm058235E |
0.396 |
|
2005 |
Tchédam Ngatcha B, Luu-The V, Labrie F, Poirier D. Androsterone 3alpha-ether-3beta-substituted and androsterone 3beta-substituted derivatives as inhibitors of type 3 17beta-hydroxysteroid dehydrogenase: chemical synthesis and structure-activity relationship. Journal of Medicinal Chemistry. 48: 5257-68. PMID 16078844 DOI: 10.1021/Jm058179H |
0.383 |
|
2005 |
Tremblay MR, Boivin RP, Luu-The V, Poirier D. Inhibitors of type 1 17beta-hydroxysteroid dehydrogenase with reduced estrogenic activity: modifications of the positions 3 and 6 of estradiol. Journal of Enzyme Inhibition and Medicinal Chemistry. 20: 153-63. PMID 15968820 DOI: 10.1080/14756360500043307 |
0.422 |
|
2005 |
Maltais R, Mercier C, Labrie F, Poirier D. Solid-phase synthesis of model libraries of 3alpha,17beta-dihydroxy-16alpha-(aminoethyl-N-substituted)-5alpha-androstanes for the development of steroidal therapeutic agents. Molecular Diversity. 9: 67-79. PMID 15789554 DOI: 10.1007/S11030-005-1312-Z |
0.657 |
|
2004 |
Bérubé M, Poirier D. Synthesis of simplified hybrid inhibitors of type 1 17beta-hydroxysteroid dehydrogenase via cross-metathesis and sonogashira coupling Reactions. Organic Letters. 6: 3127-30. PMID 15330604 DOI: 10.1021/Ol048820U |
0.424 |
|
2004 |
Maltais R, Tremblay MR, Ciobanu LC, Poirier D. Steroids and combinatorial chemistry. Journal of Combinatorial Chemistry. 6: 443-56. PMID 15244402 DOI: 10.1021/Cc030118M |
0.778 |
|
2004 |
Bydal P, Auger S, Poirier D. Inhibition of type 2 17beta-hydroxysteroid dehydrogenase by estradiol derivatives bearing a lactone on the D-ring: structure-activity relationships. Steroids. 69: 325-42. PMID 15219411 DOI: 10.1016/J.Steroids.2004.03.002 |
0.439 |
|
2003 |
Ciobanu LC, Luu-The V, Martel C, Labrie F, Poirier D. Inhibition of estrone sulfate-induced uterine growth by potent nonestrogenic steroidal inhibitors of steroid sulfatase. Cancer Research. 63: 6442-6. PMID 14559834 |
0.804 |
|
2003 |
Ciobanu LC, Poirier D. Solid-phase parallel synthesis of 17alpha-substituted estradiol sulfamate and phenol libraries using the multidetachable sulfamate linker. Journal of Combinatorial Chemistry. 5: 429-40. PMID 12857111 DOI: 10.1021/Cc020115U |
0.813 |
|
2003 |
Ciobanu LC, Boivin RP, Luu-The V, Poirier D. 3Beta-sulfamate derivatives of C19 and C21 steroids bearing a t-butylbenzyl or a benzyl group: synthesis and evaluation as non-estrogenic and non-androgenic steroid sulfatase inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry. 18: 15-26. PMID 12751816 DOI: 10.1080/1475636031000069282 |
0.81 |
|
2003 |
Radu I, Poirier D, Provencher L. Corrigendum to “New efficient pathway for the synthesis of 3-aminoestrone” Tetrahedron Letters. 44: 3431. DOI: 10.1016/S0040-4039(03)00585-9 |
0.624 |
|
2002 |
Tchédam-Ngatcha B, Luu-The V, Poirier D. Androsterone derivatives substituted at position 16: chemical synthesis, inhibition of type 3 17beta-hydroxysteroid dehydrogenase, binding affinity for steroid receptors and proliferative/antiproliferative activity on Shionogi (AR+) cells. Journal of Enzyme Inhibition and Medicinal Chemistry. 17: 155-65. PMID 12443041 DOI: 10.1080/1475636021000002067 |
0.45 |
|
2002 |
Poirier D, Ciobanu LC, Bérubé M. A multidetachable sulfamate linker successfully used in a solid-phase strategy to generate libraries of sulfamate and phenol derivatives. Bioorganic & Medicinal Chemistry Letters. 12: 2833-8. PMID 12270157 DOI: 10.1016/S0960-894X(02)00637-6 |
0.808 |
|
2002 |
Ciobanu LC, Luu-The V, Poirier D. Nonsteroidal compounds designed to mimic potent steroid sulfatase inhibitors. The Journal of Steroid Biochemistry and Molecular Biology. 80: 339-53. PMID 11948019 DOI: 10.1016/S0960-0760(02)00024-9 |
0.819 |
|
2002 |
Maltais R, Luu-The V, Poirier D. Synthesis and optimization of a new family of type 3 17 beta-hydroxysteroid dehydrogenase inhibitors by parallel liquid-phase chemistry. Journal of Medicinal Chemistry. 45: 640-53. PMID 11806715 DOI: 10.1021/Jm010286Y |
0.653 |
|
2002 |
Radu II, Poirier D, Provencher L. New efficient pathway for the synthesis of 3-aminoestrone Tetrahedron Letters. 43: 7617-7619. DOI: 10.1016/S0040-4039(02)01823-3 |
0.63 |
|
2001 |
Maltais R, Luu-The V, Poirier D. Parallel solid-phase synthesis of 3β-peptido-3α-hydroxy-5α-androstan-17-one derivatives for inhibition of Type 3 17β-hydroxysteroid dehydrogenase Bioorganic and Medicinal Chemistry. 9: 3101-3111. PMID 11711285 DOI: 10.1016/S0968-0896(01)00182-1 |
0.726 |
|
2001 |
Ciobanu LC, Boivin RP, Luu-The V, Poirier D. Synthesis and steroid sulphatase inhibitory activity of C19- and C21-steroidal derivatives bearing a benzyl-inhibiting group. European Journal of Medicinal Chemistry. 36: 659-71. PMID 11600235 DOI: 10.1016/S0223-5234(01)01262-4 |
0.804 |
|
2001 |
Tremblay MR, Lin SX, Poirier D. Chemical synthesis of 16beta-propylaminoacyl derivatives of estradiol and their inhibitory potency on type 1 17beta-hydroxysteroid dehydrogenase and binding affinity on steroid receptors. Steroids. 66: 821-31. PMID 11576622 DOI: 10.1016/S0039-128X(01)00116-7 |
0.395 |
|
2001 |
Poirier D, Bydal P, Tremblay MR, Sam KM, Luu-The V. Inhibitors of type II 17beta-hydroxysteroid dehydrogenase. Molecular and Cellular Endocrinology. 171: 119-28. PMID 11165020 DOI: 10.1016/S0303-7207(00)00427-5 |
0.407 |
|
2000 |
Maltais R, Tremblay MR, Poirier D. Solid-phase synthesis of hydroxysteroid derivatives using the diethylsilyloxy linker Journal of Combinatorial Chemistry. 2: 604-614. PMID 11126290 DOI: 10.1021/Cc0000242 |
0.676 |
|
2000 |
Boivin RP, Luu-The V, Lachance R, Labrie F, Poirier D. Structure-activity relationships of 17alpha-derivatives of estradiol as inhibitors of steroid sulfatase. Journal of Medicinal Chemistry. 43: 4465-78. PMID 11087571 DOI: 10.1021/Jm0001166 |
0.463 |
|
2000 |
Ngatcha BT, Luu-The V, Poirier D. Androsterone 3β-substituted derivatives as inhibitors of type 3 17β-hydroxysteroid dehydrogenase Bioorganic and Medicinal Chemistry Letters. 10: 2533-2536. PMID 11086723 DOI: 10.1016/S0960-894X(00)00517-5 |
0.478 |
|
2000 |
Ciobanu LC, Maltais R, Poirier D. The sulfamate functional group as a new anchor for solid-phase organic synthesis Organic Letters. 2: 445-8. PMID 10814347 DOI: 10.1021/Ol990381P |
0.775 |
|
2000 |
Sam KM, Labrie F, Poirier D. N-butyl-N-methyl-11-(3'-hydroxy-21',17'-carbolactone-19'-nor-17'α- pregna-1',3',5'(10')-trien-7'α-yl)-undecanamide: An inhibitor of type 2 17β-hydroxysteroid dehydrogenase that does not have oestrogenic or androgenic activity European Journal of Medicinal Chemistry. 35: 217-225. PMID 10758283 DOI: 10.1016/S0223-5234(00)00124-0 |
0.388 |
|
2000 |
Tremblay MR, Poirier D. Solid-phase synthesis of phenolic steroids: From optimization studies to a convenient procedure for combinatorial synthesis of biologically relevant estradiol derivatives Journal of Combinatorial Chemistry. 2: 48-65. PMID 10750486 DOI: 10.1021/Cc9900504 |
0.469 |
|
2000 |
Maltais R, Bérubé M, Marion O, Labrecque R, Poirier D. Efficient coupling and solid-phase synthesis of steroidal ketone derivative using polymer-bound glycerol Tetrahedron Letters. 41: 1691-1694. DOI: 10.1016/S0040-4039(00)00050-2 |
0.638 |
|
1999 |
Godin C, Provost PR, Poirier D, Blomquist CH, Tremblay Y. Separation by thin-layer chromatography of the most common androgen-derived C19 steroids formed by mammalian cells. Steroids. 64: 767-9. PMID 10577833 DOI: 10.1016/S0039-128X(99)00063-X |
0.317 |
|
1999 |
Boivin RP, Labrie F, Poirier D. 17α-Alkan (or alkyn) amide derivatives of estradiol as inhibitors of steroid-sulfatase activity Steroids. 64: 825-833. PMID 10576217 DOI: 10.1016/S0039-128X(99)00060-4 |
0.488 |
|
1999 |
Tremblay MR, Simard J, Poirier D. Parallel solid-phase synthesis of a model library of 7α-alkylamide estradiol derivatives as potential estrogen receptor antagonists Bioorganic and Medicinal Chemistry Letters. 9: 2827-2832. PMID 10522700 DOI: 10.1016/S0960-894X(99)00487-4 |
0.413 |
|
1999 |
Tremblay MR, Luu-The V, Leblanc G, Noël P, Breton E, Labrie F, Poirier D. Spironolactone-related inhibitors of type II 17beta-hydroxysteroid dehydrogenase: chemical synthesis, receptor binding affinities, and proliferative/antiproliferative activities. Bioorganic & Medicinal Chemistry. 7: 1013-23. PMID 10428369 DOI: 10.1016/S0968-0896(98)00260-0 |
0.412 |
|
1999 |
Qiu W, Zhu DW, Azzi A, Campbell RL, Qi H, Poirier D, Lin SX. Two non-reactive ternary complexes of estrogenic 17beta-hydroxysteroid dehydrogenase: crystallization and preliminary structural analysis. The Journal of Steroid Biochemistry and Molecular Biology. 68: 239-44. PMID 10416839 DOI: 10.1016/S0960-0760(99)00036-9 |
0.311 |
|
1999 |
Ciobanu LC, Boivin RP, Luu-The V, Labrie F, Poirier D. Potent inhibition of steroid sulfatase activity by 3-O-sulfamate 17alpha-benzyl(or 4'-tert-butylbenzyl)estra-1,3,5(10)-trienes: combination of two substituents at positions C3 and c17alpha of estradiol. Journal of Medicinal Chemistry. 42: 2280-6. PMID 10377235 DOI: 10.1021/Jm980677L |
0.823 |
|
1999 |
Poirier D, Ciobanu LC, Maltais R. Steroid sulfatase inhibitors Expert Opinion On Therapeutic Patents. 9: 1083-1099. DOI: 10.1517/13543776.9.8.1083 |
0.793 |
|
1999 |
Tremblay MR, Poirier D. Solid-phase synthesis of phenolic steroids: Towards combinatorial libraries of estradiol derivatives Tetrahedron Letters. 40: 1277-1280. DOI: 10.1016/S0040-4039(98)02640-9 |
0.439 |
|
1998 |
Poirier D, Boivin RP. 17α-alkyl- or 17α-substituted benzyl-17β-estradiols: A new family of estrone-sulfatase inhibitors Bioorganic and Medicinal Chemistry Letters. 8: 1891-1896. PMID 9873454 DOI: 10.1016/S0960-894X(98)00330-8 |
0.466 |
|
1998 |
Tremblay MR, Poirier D. Overview of a rational approach to design type I 17β-hydroxysteroid dehydrogenase inhibitors without estrogenic activity: Chemical synthesis and biological evaluation Journal of Steroid Biochemistry and Molecular Biology. 66: 179-191. PMID 9744515 DOI: 10.1016/S0960-0760(98)00043-0 |
0.507 |
|
1998 |
Poirier D, Dionne P, Auger S. A 6β-(thiaheptanamide) derivative of estradiol as inhibitor of 17β-hydroxysteroid dehydrogenase type 1 Journal of Steroid Biochemistry and Molecular Biology. 64: 83-90. PMID 9569013 DOI: 10.1016/S0960-0760(97)00136-2 |
0.478 |
|
1998 |
Maltais R, Poirier D. A solution-phase combinatorial parallel synthesis of 3β-amido-3α- hydroxy 5α-androstane-17-ones Tetrahedron Letters. 39: 4151-4154. DOI: 10.1016/S0040-4039(98)00772-2 |
0.699 |
|
1997 |
Dionne P, Ngatcha BT, Poirier D. D-ring allyl derivatives of 17β- and 17α-estradiols: Chemical synthesis and 13C NMR data Steroids. 62: 674-681. PMID 9381515 DOI: 10.1016/S0039-128X(97)00067-6 |
0.408 |
|
1996 |
Pelletier JD, Poirier D. Synthesis and evaluation of estradiol derivatives with 16α-(bromoalkylamide), 16α-(bromoalkyl) or 16α-(Bromoalkynyl) side chain as inhibitors of 17β-hydroxysteroid dehydrogenase type 1 without estrogenic activity Bioorganic and Medicinal Chemistry. 4: 1617-1628. PMID 8931931 DOI: 10.1016/0968-0896(96)00154-X |
0.504 |
|
1996 |
Bydal P, Sam KM, Poirier D. Steroid-hindered 17β-tertiary alcohol: Characterization of dehydrated compounds Steroids. 61: 349-353. PMID 8776797 DOI: 10.1016/0039-128X(96)00036-0 |
0.422 |
|
1996 |
Tremblay MR, Poirier D. Synthesis of 16-[carbamoyl(bromomethyl)alkyl]estradiol: a potential dual-action inhibitor designed to blockade estrogen action and biosynthesis Journal of the Chemical Society-Perkin Transactions 1. 2765-2771. DOI: 10.1039/P19960002765 |
0.442 |
|
1996 |
Poirier D, Mérand Y, Labrie C, Labrie F. D-ring alkylamide derivatives of estradiol: Effect on ER-binding affinity and antiestrogenic activity Bioorganic and Medicinal Chemistry Letters. 6: 2537-2542. DOI: 10.1016/0960-894X(96)00472-6 |
0.426 |
|
1995 |
Dionne P, Poirier D. 13C nuclear magnetic resonance study of 17α-substituted estradiols Steroids. 60: 830-836. PMID 8650707 DOI: 10.1016/0039-128X(95)00147-I |
0.332 |
|
1995 |
Auger S, Mérand Y, Pelletier JD, Poirier D, Labrie F. Synthesis and biological activities of thioether derivatives related to the antiestrogens tamoxifen and ICI 164384. The Journal of Steroid Biochemistry and Molecular Biology. 52: 547-65. PMID 7779759 DOI: 10.1016/0960-0760(95)00014-Q |
0.426 |
|
1995 |
Tremblay MR, Auger S, Poirier D. Synthesis of 16-(bromoalkyl)-estradiols having inhibitory effect on human placental estradiol 17β-hydroxysteroid dehydrogenase (17-β-HSD type 1) Bioorganic and Medicinal Chemistry. 3: 505-523. PMID 7648200 DOI: 10.1016/0968-0896(95)00041-E |
0.464 |
|
1995 |
Sam KM, Auger S, Luu-The V, Poirier D. Steroidal spiro-gamma-lactones that inhibit 17 beta-hydroxysteroid dehydrogenase activity in human placental microsomes. Journal of Medicinal Chemistry. 38: 4518-28. PMID 7473580 DOI: 10.1021/Jm00022A018 |
0.371 |
|
1995 |
Tremblay MR, Auger S, Poirier D. A convenient synthetic method for alpha-alkylation of steroidal 17-ketone: Preparation of 16β-(THPO-heptyl)-estradiol Synthetic Communications. 25: 2483-2495. DOI: 10.1080/00397919508015454 |
0.363 |
|
1994 |
Poirier D, Auger S, Merand Y, Simard J, Labrie F. Synthesis and Antiestrogenic Activity of Diaryl Thioether Derivatives Journal of Medicinal Chemistry. 37: 1115-1125. PMID 8164253 DOI: 10.1021/Jm00034A009 |
0.441 |
|
1994 |
Pelletier JD, Labrie F, Poirier D. N-butyl, N-methyl, 11-[3′,17′ β-(dihydroxy)-1′,3′,5′(10′)- estratrien-16′ α-yl]-9(R/S)-bromo undecanamide: synthesis and 17β-HSD inhibiting, estrogenic and antiestrogenic activities Steroids. 59: 536-547. PMID 7846736 DOI: 10.1016/0039-128X(94)90072-8 |
0.486 |
|
1994 |
Auger S, Luu-The V, Sam KM, Poirier D. 3-Hydroxy-19-nor-17α-pregna-1,3,5(10)-triene-21,17β-carbolactone as inhibitor of 17β-hydroxysteroid dehydrogenase type 2 Bioorganic & Medicinal Chemistry Letters. 4: 2045-2048. DOI: 10.1016/S0960-894X(01)80560-6 |
0.462 |
|
1994 |
Sam KM, Boivin RP, Auger S, Poirier D. 16α-propyl derivatives of estradiol as inhibitors of 17β-hydroxysteroid dehydrogenase type 1 Bioorganic & Medicinal Chemistry Letters. 4: 2129-2132. DOI: 10.1016/S0960-894X(01)80115-3 |
0.44 |
|
1991 |
Poirier D, Labrie C, Mérand Y, Labrie F. Synthesis and biological activity of 17α-alkynylamide derivatives of estradiol Journal of Steroid Biochemistry and Molecular Biology. 38: 759-774. PMID 2064992 DOI: 10.1016/0960-0760(91)90090-R |
0.444 |
|
1991 |
Poulin R, Baker D, Poirier D, Labrie F. Multiple actions of synthetic 'progestins' on the growth of ZR-75-1 human breast cancer cells: An in vitro model for the simultaneous assay of androgen, progestin, estrogen, and glucocorticoid agonistic and antagonistic activities of steroids Breast Cancer Research and Treatment. 17: 197-210. PMID 1645605 DOI: 10.1007/Bf01806369 |
0.307 |
|
1990 |
Poirier D, Labrie C, Mérand Y, Labrie F. Derivatives of ethynylestradiol with oxygenated 17α-alkyl side chain: Synthesis and biological activity Journal of Steroid Biochemistry. 36: 133-142. PMID 2362442 DOI: 10.1016/0022-4731(90)90123-A |
0.418 |
|
1990 |
Poulin R, Poirier D, Thériault C, Couture J, Bélanger A, Labrie F. Wide spectrum of steroids serving as substrates for the formation of lipoidal derivatives in ZR-75-1 human breast cancer cells. Journal of Steroid Biochemistry. 35: 237-47. PMID 2308338 DOI: 10.1016/0022-4731(90)90280-6 |
0.387 |
|
1990 |
Thériault C, Poulin R, Tremblay S, Poirier D, Labrie F. Hormonal Regulation of Estradiol 17?-Hydroxysteroid Dehydrogenase Activity in the ZR-75-1 Human Breast Cancer Cell Line Annals of the New York Academy of Sciences. 595: 419-421. DOI: 10.1111/J.1749-6632.1990.Tb34323.X |
0.301 |
|
1987 |
Burnell RH, Jean M, Poirier D. Synthesis of taxodione Canadian Journal of Chemistry. 65: 775-781. DOI: 10.1139/V87-132 |
0.318 |
|
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