Alexander Meissner - Publications

Biology, Molecular and Cellular Harvard University, Cambridge, MA, United States 
Genetics, Neuroscience Biology

111 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Blanco MA, Sykes DB, Gu L, Wu M, Petroni R, Karnik R, Wawer M, Rico J, Li H, Jacobus WD, Jambhekar A, Cheloufi S, Meissner A, Hochedlinger K, Scadden DT, et al. Chromatin-state barriers enforce an irreversible mammalian cell fate decision. Cell Reports. 37: 109967. PMID 34758323 DOI: 10.1016/j.celrep.2021.109967  0.322
2021 Yagi M, Ji F, Charlton J, Cristea S, Messemer K, Horwitz N, Di Stefano B, Tsopoulidis N, Hoetker MS, Huebner AJ, Bar-Nur O, Almada AE, Yamamoto M, Patelunas A, Goldhamer DJ, ... ... Meissner A, et al. Dissecting dual roles of MyoD during lineage conversion to mature myocytes and myogenic stem cells. Genes & Development. PMID 34413137 DOI: 10.1101/gad.348678.121  0.407
2021 Wu HJ, Landshammer A, Stamenova EK, Bolondi A, Kretzmer H, Meissner A, Michor F. Topological isolation of developmental regulators in mammalian genomes. Nature Communications. 12: 4897. PMID 34385432 DOI: 10.1038/s41467-021-24951-7  0.309
2021 Gu H, Raman AT, Wang X, Gaiti F, Chaligne R, Mohammad AW, Arczewska A, Smith ZD, Landau DA, Aryee MJ, Meissner A, Gnirke A. Smart-RRBS for single-cell methylome and transcriptome analysis. Nature Protocols. PMID 34244697 DOI: 10.1038/s41596-021-00571-9  0.384
2021 Haggerty C, Kretzmer H, Riemenschneider C, Kumar AS, Mattei AL, Bailly N, Gottfreund J, Giesselmann P, Weigert R, Brändl B, Giehr P, Buschow R, Galonska C, von Meyenn F, Pappalardi MB, ... ... Meissner A, et al. Dnmt1 has de novo activity targeted to transposable elements. Nature Structural & Molecular Biology. PMID 34140676 DOI: 10.1038/s41594-021-00603-8  0.369
2021 Kretzmer H, Biran A, Purroy N, Lemvigh C, Clement K, Gruber M, Gu H, Rassenti L, Mohammad AW, Lesnick C, Slager SL, Braggio E, Shanafelt TD, Kay NE, Fernandes S, ... ... Meissner A, et al. Preneoplastic Alterations Define CLL DNA Methylome and Persist through Disease Progression and Therapy. Blood Cancer Discovery. 2: 54-69. PMID 33604581 DOI: 10.1158/2643-3230.BCD-19-0058  0.328
2020 Grosswendt S, Kretzmer H, Smith ZD, Kumar AS, Hetzel S, Wittler L, Klages S, Timmermann B, Mukherji S, Meissner A. Epigenetic regulator function through mouse gastrulation. Nature. 584: 102-108. PMID 32728215 DOI: 10.1038/S41586-020-2552-X  0.341
2020 Yagi M, Kabata M, Tanaka A, Ukai T, Ohta S, Nakabayashi K, Shimizu M, Hata K, Meissner A, Yamamoto T, Yamada Y. Identification of distinct loci for de novo DNA methylation by DNMT3A and DNMT3B during mammalian development. Nature Communications. 11: 3199. PMID 32581223 DOI: 10.1038/S41467-020-16989-W  0.319
2020 Charlton J, Jung EJ, Mattei AL, Bailly N, Liao J, Martin EJ, Giesselmann P, Brändl B, Stamenova EK, Müller FJ, Kiskinis E, Gnirke A, Smith ZD, Meissner A. TETs compete with DNMT3 activity in pluripotent cells at thousands of methylated somatic enhancers. Nature Genetics. PMID 32514123 DOI: 10.1038/S41588-020-0639-9  0.449
2019 Brumbaugh J, Kim IS, Ji F, Huebner AJ, Di Stefano B, Schwarz BA, Charlton J, Coffey A, Choi J, Walsh RM, Schindler JW, Anselmo A, Meissner A, Sadreyev RI, Bernstein BE, et al. Inducible histone K-to-M mutations are dynamic tools to probe the physiological role of site-specific histone methylation in vitro and in vivo. Nature Cell Biology. PMID 31659274 DOI: 10.1038/S41556-019-0403-5  0.307
2019 Di Stefano B, Luo EC, Haggerty C, Aigner S, Charlton J, Brumbaugh J, Ji F, Rabano Jiménez I, Clowers KJ, Huebner AJ, Clement K, Lipchina I, de Kort MAC, Anselmo A, Pulice J, ... ... Meissner A, et al. The RNA Helicase DDX6 Controls Cellular Plasticity by Modulating P-Body Homeostasis. Cell Stem Cell. PMID 31588046 DOI: 10.1016/J.Stem.2019.08.018  0.379
2019 Thakurela S, Sindhu C, Yurkovsky E, Riemenschneider C, Smith ZD, Nachman I, Meissner A. Differential regulation of OCT4 targets facilitates reacquisition of pluripotency. Nature Communications. 10: 4444. PMID 31570708 DOI: 10.1038/S41467-019-11741-5  0.808
2019 Tsankov AM, Wadsworth MH, Akopian V, Charlton J, Allon SJ, Arczewska A, Mead BE, Drake RS, Smith ZD, Mikkelsen TS, Shalek AK, Meissner A. Loss of DNA methyltransferase activity in primed human ES cells triggers increased cell-cell variability and transcriptional repression. Development (Cambridge, England). 146. PMID 31515224 DOI: 10.1242/Dev.174722  0.439
2019 Jönsson ME, Ludvik Brattås P, Gustafsson C, Petri R, Yudovich D, Pircs K, Verschuere S, Madsen S, Hansson J, Larsson J, Månsson R, Meissner A, Jakobsson J. Activation of neuronal genes via LINE-1 elements upon global DNA demethylation in human neural progenitors. Nature Communications. 10: 3182. PMID 31320637 DOI: 10.1038/S41467-019-11150-8  0.375
2019 Gaiti F, Chaligne R, Gu H, Brand RM, Kothen-Hill S, Schulman RC, Grigorev K, Risso D, Kim KT, Pastore A, Huang KY, Alonso A, Sheridan C, Omans ND, Biederstedt E, ... ... Meissner A, et al. Epigenetic evolution and lineage histories of chronic lymphocytic leukaemia. Nature. PMID 31092926 DOI: 10.1038/S41586-019-1198-Z  0.329
2019 Chan MM, Smith ZD, Grosswendt S, Kretzmer H, Norman TM, Adamson B, Jost M, Quinn JJ, Yang D, Jones MG, Khodaverdian A, Yosef N, Meissner A, Weissman JS. Molecular recording of mammalian embryogenesis. Nature. PMID 31086336 DOI: 10.1038/S41586-019-1184-5  0.339
2019 Modic M, Grosch M, Rot G, Schirge S, Lepko T, Yamazaki T, Lee FCY, Rusha E, Shaposhnikov D, Palo M, Merl-Pham J, Cacchiarelli D, Rogelj B, Hauck SM, von Mering C, ... Meissner A, et al. Cross-Regulation between TDP-43 and Paraspeckles Promotes Pluripotency-Differentiation Transition. Molecular Cell. PMID 31047794 DOI: 10.1016/J.Molcel.2019.03.041  0.313
2019 Pastore A, Gaiti F, Lu SX, Brand RM, Kulm S, Chaligne R, Gu H, Huang KY, Stamenova EK, Béguelin W, Jiang Y, Schulman RC, Kim KT, Alonso A, Allan JN, ... ... Meissner A, et al. Corrupted coordination of epigenetic modifications leads to diverging chromatin states and transcriptional heterogeneity in CLL. Nature Communications. 10: 1874. PMID 31015400 DOI: 10.1038/S41467-019-09645-5  0.352
2018 Zhang Y, Charlton J, Karnik R, Beerman I, Smith ZD, Gu H, Boyle P, Mi X, Clement K, Pop R, Gnirke A, Rossi DJ, Meissner A. Targets and genomic constraints of ectopic Dnmt3b expression. Elife. 7. PMID 30468428 DOI: 10.7554/Elife.40757  0.351
2018 Ichida JK, Staats KA, Davis-Dusenbery BN, Clement K, Galloway KE, Babos KN, Shi Y, Son EY, Kiskinis E, Atwater N, Gu H, Gnirke A, Meissner A, Eggan K. Comparative genomic analysis of embryonic, lineage-converted, and stem cell-derived motor neurons. Development (Cambridge, England). PMID 30337375 DOI: 10.1242/Dev.168617  0.317
2018 Cacchiarelli D, Qiu X, Srivatsan S, Manfredi A, Ziller M, Overbey E, Grimaldi A, Grimsby J, Pokharel P, Livak KJ, Li S, Meissner A, Mikkelsen TS, Rinn JL, Trapnell C. Aligning Single-Cell Developmental and Reprogramming Trajectories Identifies Molecular Determinants of Myogenic Reprogramming Outcome. Cell Systems. PMID 30195438 DOI: 10.1016/J.Cels.2018.07.006  0.363
2018 Di Stefano B, Ueda M, Sabri S, Brumbaugh J, Huebner AJ, Sahakyan A, Clement K, Clowers KJ, Erickson AR, Shioda K, Gygi SP, Gu H, Shioda T, Meissner A, Takashima Y, et al. Reduced MEK inhibition preserves genomic stability in naive human embryonic stem cells. Nature Methods. PMID 30127506 DOI: 10.1038/S41592-018-0104-1  0.359
2018 Schwarz BA, Cetinbas M, Clement K, Walsh RM, Cheloufi S, Gu H, Langkabel J, Kamiya A, Schorle H, Meissner A, Sadreyev RI, Hochedlinger K. Prospective Isolation of Poised iPSC Intermediates Reveals Principles of Cellular Reprogramming. Cell Stem Cell. PMID 30017590 DOI: 10.1016/J.Stem.2018.06.013  0.445
2018 Pasque V, Karnik R, Chronis C, Petrella P, Langerman J, Bonora G, Song J, Vanheer L, Sadhu Dimashkie A, Meissner A, Plath K. X Chromosome Dosage Influences DNA Methylation Dynamics during Reprogramming to Mouse iPSCs. Stem Cell Reports. PMID 29681539 DOI: 10.1016/J.Stemcr.2018.03.019  0.404
2018 Charlton J, Downing TL, Smith ZD, Gu H, Clement K, Pop R, Akopian V, Klages S, Santos DP, Tsankov AM, Timmermann B, Ziller MJ, Kiskinis E, Gnirke A, Meissner A. Global delay in nascent strand DNA methylation. Nature Structural & Molecular Biology. PMID 29531288 DOI: 10.1038/S41594-018-0046-4  0.422
2018 Galonska C, Charlton J, Mattei AL, Donaghey J, Clement K, Gu H, Mohammad AW, Stamenova EK, Cacchiarelli D, Klages S, Timmermann B, Cantz T, Schöler HR, Gnirke A, Ziller MJ, ... Meissner A, et al. Genome-wide tracking of dCas9-methyltransferase footprints. Nature Communications. 9: 597. PMID 29426832 DOI: 10.1038/S41467-017-02708-5  0.358
2018 Donaghey J, Thakurela S, Charlton J, Chen JS, Smith ZD, Gu H, Pop R, Clement K, Stamenova EK, Karnik R, Kelley DR, Gifford CA, Cacchiarelli D, Rinn JL, Gnirke A, ... ... Meissner A, et al. Genetic determinants and epigenetic effects of pioneer-factor occupancy. Nature Genetics. PMID 29358654 DOI: 10.1038/S41588-017-0034-3  0.818
2017 Smith ZD, Shi J, Gu H, Donaghey J, Clement K, Cacchiarelli D, Gnirke A, Michor F, Meissner A. Epigenetic restriction of extraembryonic lineages mirrors the somatic transition to cancer. Nature. 549: 543-547. PMID 28959968 DOI: 10.1038/Nature23891  0.356
2017 Choi J, Huebner AJ, Clement K, Walsh RM, Savol A, Lin K, Gu H, Di Stefano B, Brumbaugh J, Kim SY, Sharif J, Rose CM, Mohammad A, Odajima J, Charron J, ... ... Meissner A, et al. Prolonged Mek1/2 suppression impairs the developmental potential of embryonic stem cells. Nature. PMID 28746311 DOI: 10.1038/Nature23274  0.355
2017 Choi J, Clement K, Huebner AJ, Webster J, Rose CM, Brumbaugh J, Walsh RM, Lee S, Savol A, Etchegaray JP, Gu H, Boyle P, Elling U, Mostoslavsky R, Sadreyev R, ... ... Meissner A, et al. DUSP9 Modulates DNA Hypomethylation in Female Mouse Pluripotent Stem Cells. Cell Stem Cell. PMID 28366588 DOI: 10.1016/J.Stem.2017.03.002  0.796
2016 Liu LL, Brumbaugh J, Bar-Nur O, Smith Z, Stadtfeld M, Meissner A, Hochedlinger K, Michor F. Probabilistic Modeling of Reprogramming to Induced Pluripotent Stem Cells. Cell Reports. 17: 3395-3406. PMID 28009305 DOI: 10.1016/J.Celrep.2016.11.080  0.373
2016 Ziller MJ, Stamenova EK, Gu H, Gnirke A, Meissner A. Targeted bisulfite sequencing of the dynamic DNA methylome. Epigenetics & Chromatin. 9: 55. PMID 27980681 DOI: 10.1186/S13072-016-0105-1  0.33
2016 Yu VW, Yusuf RZ, Oki T, Wu J, Saez B, Wang X, Cook C, Baryawno N, Ziller MJ, Lee E, Gu H, Meissner A, Lin CP, Kharchenko PV, Scadden DT. Epigenetic Memory Underlies Cell-Autonomous Heterogeneous Behavior of Hematopoietic Stem Cells. Cell. 167: 1310-1322.e17. PMID 27863245 DOI: 10.1016/j.cell.2016.10.045  0.389
2016 Kottakis F, Nicolay BN, Roumane A, Karnik R, Gu H, Nagle JM, Boukhali M, Hayward MC, Li YY, Chen T, Liesa M, Hammerman PS, Wong KK, Hayes DN, Shirihai OS, ... ... Meissner A, et al. LKB1 loss links serine metabolism to DNA methylation and tumorigenesis. Nature. PMID 27799657 DOI: 10.1038/Nature20132  0.324
2016 Aguilar CA, Pop R, Shcherbina A, Watts A, Matheny RW, Cacchiarelli D, Han WM, Shin E, Nakhai SA, Jang YC, Carrigan CT, Gifford CA, Kottke MA, Cesana M, Lee J, ... ... Meissner A, et al. Transcriptional and Chromatin Dynamics of Muscle Regeneration after Severe Trauma. Stem Cell Reports. PMID 27773702 DOI: 10.1016/J.Stemcr.2016.09.009  0.749
2016 Libertini E, Heath SC, Hamoudi RA, Gut M, Ziller MJ, Czyz A, Ruotti V, Stunnenberg HG, Frontini M, Ouwehand WH, Meissner A, Gut IG, Beck S. Information recovery from low coverage whole-genome bisulfite sequencing. Nature Communications. 7: 11306. PMID 27346250 DOI: 10.1038/Ncomms11306  0.309
2016 Smith ZD, Sindhu C, Meissner A. Molecular features of cellular reprogramming and development. Nature Reviews. Molecular Cell Biology. 17: 139-54. PMID 26883001 DOI: 10.1038/Nrm.2016.6  0.395
2015 Tsankov AM, Akopian V, Pop R, Chetty S, Gifford CA, Daheron L, Tsankova NM, Meissner A. A qPCR ScoreCard quantifies the differentiation potential of human pluripotent stem cells. Nature Biotechnology. 33: 1182-92. PMID 26501952 DOI: 10.1038/Nbt.3387  0.787
2015 Choi J, Lee S, Mallard W, Clement K, Tagliazucchi GM, Lim H, Choi IY, Ferrari F, Tsankov AM, Pop R, Lee G, Rinn JL, Meissner A, Park PJ, Hochedlinger K. A comparison of genetically matched cell lines reveals the equivalence of human iPSCs and ESCs. Nature Biotechnology. PMID 26501951 DOI: 10.1038/Nbt.3388  0.375
2015 Aguilar CA, Shcherbina A, Ricke DO, Pop R, Carrigan CT, Gifford CA, Urso ML, Kottke MA, Meissner A. In vivo Monitoring of Transcriptional Dynamics After Lower-Limb Muscle Injury Enables Quantitative Classification of Healing. Scientific Reports. 5: 13885. PMID 26381351 DOI: 10.1038/Srep13885  0.74
2015 Das PP, Hendrix DA, Apostolou E, Buchner AH, Canver MC, Beyaz S, Ljuboja D, Kuintzle R, Kim W, Karnik R, Shao Z, Xie H, Xu J, De Los Angeles A, Zhang Y, ... ... Meissner A, et al. PRC2 Is Required to Maintain Expression of the Maternal Gtl2-Rian-Mirg Locus by Preventing De Novo DNA Methylation in Mouse Embryonic Stem Cells. Cell Reports. 12: 1456-1470. PMID 26299972 DOI: 10.1016/J.Celrep.2015.07.053  0.3
2015 Paull D, Sevilla A, Zhou H, Hahn AK, Kim H, Napolitano C, Tsankov A, Shang L, Krumholz K, Jagadeesan P, Woodard CM, Sun B, Vilboux T, Zimmer M, Forero E, ... ... Meissner A, et al. Automated, high-throughput derivation, characterization and differentiation of induced pluripotent stem cells. Nature Methods. PMID 26237226 DOI: 10.1038/Nmeth.3507  0.326
2015 Galonska C, Ziller MJ, Karnik R, Meissner A. Ground State Conditions Induce Rapid Reorganization of Core Pluripotency Factor Binding before Global Epigenetic Reprogramming. Cell Stem Cell. 17: 462-70. PMID 26235340 DOI: 10.1016/J.Stem.2015.07.005  0.329
2015 Cacchiarelli D, Trapnell C, Ziller MJ, Soumillon M, Cesana M, Karnik R, Donaghey J, Smith ZD, Ratanasirintrawoot S, Zhang X, Ho Sui SJ, Wu Z, Akopian V, Gifford CA, Doench J, ... ... Meissner A, et al. Integrative Analyses of Human Reprogramming Reveal Dynamic Nature of Induced Pluripotency. Cell. 162: 412-424. PMID 26186193 DOI: 10.1016/J.Cell.2015.06.016  0.79
2015 Liao J, Karnik R, Gu H, Ziller MJ, Clement K, Tsankov AM, Akopian V, Gifford CA, Donaghey J, Galonska C, Pop R, Reyon D, Tsai SQ, Mallard W, Joung JK, ... ... Meissner A, et al. Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells. Nature Genetics. 47: 469-78. PMID 25822089 DOI: 10.1038/Ng.3258  0.804
2015 Tsankov AM, Gu H, Akopian V, Ziller MJ, Donaghey J, Amit I, Gnirke A, Meissner A. Transcription factor binding dynamics during human ES cell differentiation. Nature. 518: 344-9. PMID 25693565 DOI: 10.1038/Nature14233  0.39
2015 Kundaje A, Meuleman W, Ernst J, Bilenky M, Yen A, Heravi-Moussavi A, Kheradpour P, Zhang Z, Wang J, Ziller MJ, Amin V, Whitaker JW, Schultz MD, Ward LD, ... ... Meissner A, et al. Integrative analysis of 111 reference human epigenomes. Nature. 518: 317-30. PMID 25693563 DOI: 10.1038/Nature14248  0.341
2015 French A, Bravery C, Smith J, Chandra A, Archibald P, Gold JD, Artzi N, Kim HW, Barker RW, Meissner A, Wu JC, Knowles JC, Williams D, García-Cardeña G, Sipp D, et al. Enabling consistency in pluripotent stem cell-derived products for research and development and clinical applications through material standards. Stem Cells Translational Medicine. 4: 217-23. PMID 25650438 DOI: 10.5966/Sctm.2014-0233  0.305
2015 Huh SJ, Clement K, Jee D, Merlini A, Choudhury S, Maruyama R, Yoo R, Chytil A, Boyle P, Ran FA, Moses HL, Barcellos-Hoff MH, Jackson-Grusby L, Meissner A, Polyak K. Age- and pregnancy-associated DNA methylation changes in mammary epithelial cells. Stem Cell Reports. 4: 297-311. PMID 25619437 DOI: 10.1016/J.Stemcr.2014.12.009  0.403
2015 Pour M, Pilzer I, Rosner R, Smith ZD, Meissner A, Nachman I. Epigenetic predisposition to reprogramming fates in somatic cells. Embo Reports. 16: 370-8. PMID 25600117 DOI: 10.15252/Embr.201439264  0.381
2015 Ziller MJ, Edri R, Yaffe Y, Donaghey J, Pop R, Mallard W, Issner R, Gifford CA, Goren A, Xing J, Gu H, Cacchiarelli D, Tsankov AM, Epstein C, Rinn JL, ... ... Meissner A, et al. Dissecting neural differentiation regulatory networks through epigenetic footprinting. Nature. 518: 355-9. PMID 25533951 DOI: 10.1038/Nature13990  0.791
2014 Pasque V, Tchieu J, Karnik R, Uyeda M, Sadhu Dimashkie A, Case D, Papp B, Bonora G, Patel S, Ho R, Schmidt R, McKee R, Sado T, Tada T, Meissner A, et al. X chromosome reactivation dynamics reveal stages of reprogramming to pluripotency. Cell. 159: 1681-97. PMID 25525883 DOI: 10.1016/J.Cell.2014.11.040  0.373
2014 Landau DA, Clement K, Ziller MJ, Boyle P, Fan J, Gu H, Stevenson K, Sougnez C, Wang L, Li S, Kotliar D, Zhang W, Ghandi M, Garraway L, Fernandes SM, ... ... Meissner A, et al. Locally disordered methylation forms the basis of intratumor methylome variation in chronic lymphocytic leukemia. Cancer Cell. 26: 813-25. PMID 25490447 DOI: 10.1016/J.Ccell.2014.10.012  0.338
2014 Smith ZD, Chan MM, Humm KC, Karnik R, Mekhoubad S, Regev A, Eggan K, Meissner A. DNA methylation dynamics of the human preimplantation embryo. Nature. 511: 611-5. PMID 25079558 DOI: 10.1038/Nature13581  0.397
2014 Ichida JK, TCW J, T C W J, Williams LA, Carter AC, Shi Y, Moura MT, Ziller M, Singh S, Amabile G, Bock C, Umezawa A, Rubin LL, Bradner JE, Akutsu H, ... Meissner A, et al. Notch inhibition allows oncogene-independent generation of iPS cells. Nature Chemical Biology. 10: 632-9. PMID 24952596 DOI: 10.1038/Nchembio.1552  0.305
2014 Sun D, Luo M, Jeong M, Rodriguez B, Xia Z, Hannah R, Wang H, Le T, Faull KF, Chen R, Gu H, Bock C, Meissner A, Göttgens B, Darlington GJ, et al. Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal. Cell Stem Cell. 14: 673-88. PMID 24792119 DOI: 10.1016/J.Stem.2014.03.002  0.326
2014 Galonska C, Smith ZD, Meissner A. In Vivo and in vitro dynamics of undifferentiated embryonic cell transcription factor 1. Stem Cell Reports. 2: 245-52. PMID 24672748 DOI: 10.1016/J.Stemcr.2014.01.007  0.381
2013 Stelzer Y, Ronen D, Bock C, Boyle P, Meissner A, Benvenisty N. Identification of novel imprinted differentially methylated regions by global analysis of human-parthenogenetic-induced pluripotent stem cells. Stem Cell Reports. 1: 79-89. PMID 24052944 DOI: 10.1016/J.Stemcr.2013.03.005  0.346
2013 Ziller MJ, Gu H, Müller F, Donaghey J, Tsai LT, Kohlbacher O, De Jager PL, Rosen ED, Bennett DA, Bernstein BE, Gnirke A, Meissner A. Charting a dynamic DNA methylation landscape of the human genome. Nature. 500: 477-81. PMID 23925113 DOI: 10.1038/Nature12433  0.415
2013 Kearns NA, Genga RM, Ziller M, Kapinas K, Peters H, Brehm MA, Meissner A, Maehr R. Generation of organized anterior foregut epithelia from pluripotent stem cells using small molecules. Stem Cell Research. 11: 1003-12. PMID 23917481 DOI: 10.1016/J.Scr.2013.06.007  0.313
2013 Karnik R, Meissner A. Browsing (Epi)genomes: a guide to data resources and epigenome browsers for stem cell researchers. Cell Stem Cell. 13: 14-21. PMID 23827707 DOI: 10.1016/J.Stem.2013.06.006  0.342
2013 Gifford CA, Ziller MJ, Gu H, Trapnell C, Donaghey J, Tsankov A, Shalek AK, Kelley DR, Shishkin AA, Issner R, Zhang X, Coyne M, Fostel JL, Holmes L, Meldrim J, ... ... Meissner A, et al. Transcriptional and epigenetic dynamics during specification of human embryonic stem cells. Cell. 153: 1149-63. PMID 23664763 DOI: 10.1016/J.Cell.2013.04.037  0.807
2013 Beerman I, Bock C, Garrison BS, Smith ZD, Gu H, Meissner A, Rossi DJ. Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging. Cell Stem Cell. 12: 413-25. PMID 23415915 DOI: 10.1016/J.Stem.2013.01.017  0.317
2013 Smith ZD, Meissner A. DNA methylation: roles in mammalian development. Nature Reviews. Genetics. 14: 204-20. PMID 23400093 DOI: 10.1038/Nrg3354  0.388
2013 Zhu J, Adli M, Zou JY, Verstappen G, Coyne M, Zhang X, Durham T, Miri M, Deshpande V, De Jager PL, Bennett DA, Houmard JA, Muoio DM, Onder TT, Camahort R, ... ... Meissner A, et al. Genome-wide chromatin state transitions associated with developmental and environmental cues. Cell. 152: 642-54. PMID 23333102 DOI: 10.1016/J.Cell.2012.12.033  0.338
2013 Smith ZD, Meissner A. The simplest explanation: passive DNA demethylation in PGCs. The Embo Journal. 32: 318-21. PMID 23299938 DOI: 10.1038/Emboj.2012.349  0.362
2012 Sindhu C, Samavarchi-Tehrani P, Meissner A. Transcription factor-mediated epigenetic reprogramming. The Journal of Biological Chemistry. 287: 30922-31. PMID 22952239 DOI: 10.1074/Jbc.R111.319046  0.342
2012 Gifford CA, Meissner A. Epigenetic obstacles encountered by transcription factors: reprogramming against all odds. Current Opinion in Genetics & Development. 22: 409-15. PMID 22922161 DOI: 10.1016/J.Gde.2012.08.002  0.775
2012 Bock C, Beerman I, Lien WH, Smith ZD, Gu H, Boyle P, Gnirke A, Fuchs E, Rossi DJ, Meissner A. DNA methylation dynamics during in vivo differentiation of blood and skin stem cells. Molecular Cell. 47: 633-47. PMID 22841485 DOI: 10.1016/J.Molcel.2012.06.019  0.413
2012 Arand J, Spieler D, Karius T, Branco MR, Meilinger D, Meissner A, Jenuwein T, Xu G, Leonhardt H, Wolf V, Walter J. In vivo control of CpG and non-CpG DNA methylation by DNA methyltransferases. Plos Genetics. 8: e1002750. PMID 22761581 DOI: 10.1371/Journal.Pgen.1002750  0.348
2012 Mekhoubad S, Bock C, de Boer AS, Kiskinis E, Meissner A, Eggan K. Erosion of dosage compensation impacts human iPSC disease modeling. Cell Stem Cell. 10: 595-609. PMID 22560080 DOI: 10.1016/J.Stem.2012.02.014  0.318
2012 Brinkman AB, Gu H, Bartels SJ, Zhang Y, Matarese F, Simmer F, Marks H, Bock C, Gnirke A, Meissner A, Stunnenberg HG. Sequential ChIP-bisulfite sequencing enables direct genome-scale investigation of chromatin and DNA methylation cross-talk. Genome Research. 22: 1128-38. PMID 22466170 DOI: 10.1101/Gr.133728.111  0.356
2012 Smith ZD, Chan MM, Mikkelsen TS, Gu H, Gnirke A, Regev A, Meissner A. A unique regulatory phase of DNA methylation in the early mammalian embryo. Nature. 484: 339-44. PMID 22456710 DOI: 10.1038/Nature10960  0.325
2012 Akopian V, Chan MM, Clement K, Galonska C, Gifford CA, Lehtola E, Liao J, Samavarchi-Tehrani P, Sindhu C, Smith ZD, Tsankov AM, Webster J, Zhang Y, Ziller MJ, Meissner A. Epigenomics and chromatin dynamics. Genome Biology. 13: 313. PMID 22364154 DOI: 10.1186/Gb-2012-13-2-313  0.747
2012 Challen GA, Sun D, Jeong M, Luo M, Jelinek J, Berg JS, Bock C, Vasanthakumar A, Gu H, Xi Y, Liang S, Lu Y, Darlington GJ, Meissner A, Issa JP, et al. Dnmt3a is essential for hematopoietic stem cell differentiation. Nature Genetics. 44: 23-31. PMID 22138693 DOI: 10.1038/Ng.1009  0.373
2012 Xu H, Yi BA, Wu H, Bock C, Gu H, Lui KO, Park JH, Shao Y, Riley AK, Domian IJ, Hu E, Willette R, Lepore J, Meissner A, Wang Z, et al. Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature. Cell Research. 22: 142-54. PMID 22064699 DOI: 10.1038/Cr.2011.171  0.373
2011 Ziller MJ, Müller F, Liao J, Zhang Y, Gu H, Bock C, Boyle P, Epstein CB, Bernstein BE, Lengauer T, Gnirke A, Meissner A. Genomic distribution and inter-sample variation of non-CpG methylation across human cell types. Plos Genetics. 7: e1002389. PMID 22174693 DOI: 10.1371/Journal.Pgen.1002389  0.389
2011 Shearstone JR, Pop R, Bock C, Boyle P, Meissner A, Socolovsky M. Global DNA demethylation during mouse erythropoiesis in vivo. Science (New York, N.Y.). 334: 799-802. PMID 22076376 DOI: 10.1126/Science.1207306  0.38
2011 Meissner A. Guiding DNA methylation. Cell Stem Cell. 9: 388-90. PMID 22056134 DOI: 10.1016/J.Stem.2011.10.014  0.315
2011 Zacharek SJ, Fillmore CM, Lau AN, Gludish DW, Chou A, Ho JW, Zamponi R, Gazit R, Bock C, Jäger N, Smith ZD, Kim TM, Saunders AH, Wong J, Lee JH, ... ... Meissner A, et al. Lung stem cell self-renewal relies on BMI1-dependent control of expression at imprinted loci. Cell Stem Cell. 9: 272-81. PMID 21885022 DOI: 10.1016/J.Stem.2011.07.007  0.315
2011 Guttman M, Donaghey J, Carey BW, Garber M, Grenier JK, Munson G, Young G, Lucas AB, Ach R, Bruhn L, Yang X, Amit I, Meissner A, Regev A, Rinn JL, et al. lincRNAs act in the circuitry controlling pluripotency and differentiation. Nature. 477: 295-300. PMID 21874018 DOI: 10.1038/Nature10398  0.356
2011 Thomson M, Liu SJ, Zou LN, Smith Z, Meissner A, Ramanathan S. Pluripotency factors in embryonic stem cells regulate differentiation into germ layers. Cell. 145: 875-89. PMID 21663792 DOI: 10.1016/J.Cell.2011.05.017  0.348
2011 Bock C, Kiskinis E, Verstappen G, Gu H, Boulting G, Smith ZD, Ziller M, Croft GF, Amoroso MW, Oakley DH, Gnirke A, Eggan K, Meissner A. Reference Maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines. Cell. 144: 439-52. PMID 21295703 DOI: 10.1016/J.Cell.2010.12.032  0.418
2011 Koche RP, Smith ZD, Adli M, Gu H, Ku M, Gnirke A, Bernstein BE, Meissner A. Reprogramming factor expression initiates widespread targeted chromatin remodeling. Cell Stem Cell. 8: 96-105. PMID 21211784 DOI: 10.1016/J.Stem.2010.12.001  0.401
2010 Tomazou EM, Meissner A. Epigenetic regulation of pluripotency. Advances in Experimental Medicine and Biology. 695: 26-40. PMID 21222197 DOI: 10.1007/978-1-4419-7037-4_3  0.438
2010 Wirt SE, Adler AS, Gebala V, Weimann JM, Schaffer BE, Saddic LA, Viatour P, Vogel H, Chang HY, Meissner A, Sage J. G1 arrest and differentiation can occur independently of Rb family function. The Journal of Cell Biology. 191: 809-25. PMID 21059851 DOI: 10.1083/Jcb.201003048  0.308
2010 Meissner A. Epigenetic modifications in pluripotent and differentiated cells. Nature Biotechnology. 28: 1079-88. PMID 20944600 DOI: 10.1038/Nbt.1684  0.458
2010 Warren L, Manos PD, Ahfeldt T, Loh YH, Li H, Lau F, Ebina W, Mandal PK, Smith ZD, Meissner A, Daley GQ, Brack AS, Collins JJ, Cowan C, Schlaeger TM, et al. Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell. 7: 618-30. PMID 20888316 DOI: 10.1016/J.Stem.2010.08.012  0.376
2010 Harris RA, Wang T, Coarfa C, Nagarajan RP, Hong C, Downey SL, Johnson BE, Fouse SD, Delaney A, Zhao Y, Olshen A, Ballinger T, Zhou X, Forsberg KJ, Gu J, ... ... Meissner A, et al. Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications. Nature Biotechnology. 28: 1097-105. PMID 20852635 DOI: 10.1038/Nbt.1682  0.341
2010 Bock C, Tomazou EM, Brinkman AB, Müller F, Simmer F, Gu H, Jäger N, Gnirke A, Stunnenberg HG, Meissner A. Quantitative comparison of genome-wide DNA methylation mapping technologies. Nature Biotechnology. 28: 1106-14. PMID 20852634 DOI: 10.1038/Nbt.1681  0.368
2010 Artyomov MN, Meissner A, Chakraborty AK. A model for genetic and epigenetic regulatory networks identifies rare pathways for transcription factor induced pluripotency. Plos Computational Biology. 6: e1000785. PMID 20485562 DOI: 10.1371/Journal.Pcbi.1000785  0.369
2010 Smith ZD, Nachman I, Regev A, Meissner A. Dynamic single-cell imaging of direct reprogramming reveals an early specifying event. Nature Biotechnology. 28: 521-6. PMID 20436460 DOI: 10.1038/Nbt.1632  0.367
2009 Han DW, Do JT, Araúzo-Bravo MJ, Lee SH, Meissner A, Lee HT, Jaenisch R, Schöler HR. Epigenetic hierarchy governing Nestin expression. Stem Cells (Dayton, Ohio). 27: 1088-97. PMID 19415779 DOI: 10.1002/Stem.43  0.361
2009 Daley GQ, Lensch MW, Jaenisch R, Meissner A, Plath K, Yamanaka S. Broader implications of defining standards for the pluripotency of iPSCs. Cell Stem Cell. 4: 200-1; author reply . PMID 19265657 DOI: 10.1016/J.Stem.2009.02.009  0.376
2009 Amabile G, Meissner A. Induced pluripotent stem cells: current progress and potential for regenerative medicine. Trends in Molecular Medicine. 15: 59-68. PMID 19162546 DOI: 10.1016/J.Molmed.2008.12.003  0.404
2009 Meissner A, Eminli S, Jaenisch R. Derivation and manipulation of murine embryonic stem cells. Methods in Molecular Biology (Clifton, N.J.). 482: 3-19. PMID 19089346 DOI: 10.1007/978-1-59745-060-7_1  0.339
2008 Meissner A, Mikkelsen TS, Gu H, Wernig M, Hanna J, Sivachenko A, Zhang X, Bernstein BE, Nusbaum C, Jaffe DB, Gnirke A, Jaenisch R, Lander ES. Genome-scale DNA methylation maps of pluripotent and differentiated cells. Nature. 454: 766-70. PMID 18600261 DOI: 10.1038/Nature07107  0.443
2008 Markoulaki S, Meissner A, Jaenisch R. Somatic cell nuclear transfer and derivation of embryonic stem cells in the mouse. Methods (San Diego, Calif.). 45: 101-14. PMID 18593608 DOI: 10.1016/J.Ymeth.2008.04.002  0.35
2008 Mikkelsen TS, Hanna J, Zhang X, Ku M, Wernig M, Schorderet P, Bernstein BE, Jaenisch R, Lander ES, Meissner A. Dissecting direct reprogramming through integrative genomic analysis. Nature. 454: 49-55. PMID 18509334 DOI: 10.1038/Nature07056  0.435
2008 Fouse SD, Shen Y, Pellegrini M, Cole S, Meissner A, Van Neste L, Jaenisch R, Fan G. Promoter CpG methylation contributes to ES cell gene regulation in parallel with Oct4/Nanog, PcG complex, and histone H3 K4/K27 trimethylation. Cell Stem Cell. 2: 160-9. PMID 18371437 DOI: 10.1016/J.Stem.2007.12.011  0.392
2008 Wernig M, Meissner A, Cassady JP, Jaenisch R. c-Myc is dispensable for direct reprogramming of mouse fibroblasts. Cell Stem Cell. 2: 10-2. PMID 18371415 DOI: 10.1016/J.Stem.2007.12.001  0.328
2007 Hanna J, Wernig M, Markoulaki S, Sun CW, Meissner A, Cassady JP, Beard C, Brambrink T, Wu LC, Townes TM, Jaenisch R. Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin. Science (New York, N.Y.). 318: 1920-3. PMID 18063756 DOI: 10.1126/Science.1152092  0.364
2007 Meissner A, Wernig M, Jaenisch R. Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells. Nature Biotechnology. 25: 1177-81. PMID 17724450 DOI: 10.1038/Nbt1335  0.358
2007 Mikkelsen TS, Ku M, Jaffe DB, Issac B, Lieberman E, Giannoukos G, Alvarez P, Brockman W, Kim TK, Koche RP, Lee W, Mendenhall E, O'Donovan A, Presser A, Russ C, ... ... Meissner A, et al. Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature. 448: 553-60. PMID 17603471 DOI: 10.1038/Nature06008  0.387
2007 Wernig M, Meissner A, Foreman R, Brambrink T, Ku M, Hochedlinger K, Bernstein BE, Jaenisch R. In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature. 448: 318-24. PMID 17554336 DOI: 10.1038/Nature05944  0.42
2007 Bernstein BE, Meissner A, Lander ES. The mammalian epigenome. Cell. 128: 669-81. PMID 17320505 DOI: 10.1016/J.Cell.2007.01.033  0.317
2006 Meissner A, Jaenisch R. Mammalian nuclear transfer. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 235: 2460-9. PMID 16881069 DOI: 10.1002/Dvdy.20915  0.326
2006 Blelloch R, Wang Z, Meissner A, Pollard S, Smith A, Jaenisch R. Reprogramming efficiency following somatic cell nuclear transfer is influenced by the differentiation and methylation state of the donor nucleus. Stem Cells (Dayton, Ohio). 24: 2007-13. PMID 16709876 DOI: 10.1634/Stemcells.2006-0050  0.394
2006 Bernstein BE, Mikkelsen TS, Xie X, Kamal M, Huebert DJ, Cuff J, Fry B, Meissner A, Wernig M, Plath K, Jaenisch R, Wagschal A, Feil R, Schreiber SL, Lander ES. A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell. 125: 315-26. PMID 16630819 DOI: 10.1016/J.Cell.2006.02.041  0.411
2005 Meissner A, Gnirke A, Bell GW, Ramsahoye B, Lander ES, Jaenisch R. Reduced representation bisulfite sequencing for comparative high-resolution DNA methylation analysis. Nucleic Acids Research. 33: 5868-77. PMID 16224102 DOI: 10.1093/Nar/Gki901  0.335
2004 Gaudet F, Rideout WM, Meissner A, Dausman J, Leonhardt H, Jaenisch R. Dnmt1 expression in pre- and postimplantation embryogenesis and the maintenance of IAP silencing. Molecular and Cellular Biology. 24: 1640-8. PMID 14749379 DOI: 10.1128/Mcb.24.4.1640-1648.2004  0.315
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