| Year |
Citation |
Score |
| 2020 |
Yoon Y, Voloudakis G, Doran N, Zhang E, Dimovasili C, Chen L, Shao Z, Darmanis S, Tang C, Tang J, Wang VX, Hof PR, Robakis NK, Georgakopoulos A. PS1 FAD mutants decrease ephrinB2-regulated angiogenic functions, ischemia-induced brain neovascularization and neuronal survival. Molecular Psychiatry. PMID 32541930 DOI: 10.1038/S41380-020-0812-7 |
0.373 |
|
| 2018 |
Warren NA, Voloudakis G, Yoon Y, Robakis NK, Georgakopoulos A. The product of the γ-secretase processing of ephrinB2 regulates VE-cadherin complexes and angiogenesis. Cellular and Molecular Life Sciences : Cmls. PMID 29428965 DOI: 10.1007/S00018-018-2762-7 |
0.416 |
|
| 2017 |
Huang Q, Voloudakis G, Ren Y, Yoon Y, Zhang E, Kajiwara Y, Shao Z, Xuan Z, Lebedev D, Georgakopoulos A, Robakis NK. Presenilin1/γ-secretase protects neurons from glucose deprivation-induced death by regulating miR-212 and PEA15. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 28855274 DOI: 10.1096/Fj.201700447Rr |
0.308 |
|
| 2016 |
Nikolakopoulou AM, Georgakopoulos A, Robakis NK. Presenilin 1 promotes trypsin-induced neuroprotection via the PAR2/ERK signaling pathway. Effects of presenilin 1 FAD mutations. Neurobiology of Aging. 42: 41-9. PMID 27143420 DOI: 10.1016/J.Neurobiolaging.2016.02.028 |
0.392 |
|
| 2016 |
Moreno JL, Miranda-Azpiazu P, García-Bea A, Younkin J, Cui M, Kozlenkov A, Ben-Ezra A, Voloudakis G, Fakira AK, Baki L, Ge Y, Georgakopoulos A, Morón JA, Milligan G, López-Giménez JF, et al. Allosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophrenia. Science Signaling. 9: ra5. PMID 26758213 DOI: 10.1126/Scisignal.Aab0467 |
0.331 |
|
| 2015 |
Bruban J, Voloudakis G, Huang Q, Kajiwara Y, Al Rahim M, Yoon Y, Shioi J, Gama Sosa MA, Shao Z, Georgakopoulos A, Robakis NK. Presenilin 1 is necessary for neuronal, but not glial, EGFR expression and neuroprotection via γ-secretase-independent transcriptional mechanisms. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 25985800 DOI: 10.1096/Fj.15-270645 |
0.372 |
|
| 2014 |
Robakis NK, Georgakopoulos A. Allelic interference: a mechanism for trans-dominant transmission of loss of function in the neurodegeneration of familial Alzheimer's disease. Neuro-Degenerative Diseases. 13: 126-30. PMID 24081144 DOI: 10.1159/000354241 |
0.361 |
|
| 2013 |
Xuan Z, Barthet G, Shioi J, Xu J, Georgakopoulos A, Bruban J, Robakis NK. Presenilin-1/γ-secretase controls glutamate release, tyrosine phosphorylation, and surface expression of N-methyl-D-aspartate receptor (NMDAR) subunit GluN2B. The Journal of Biological Chemistry. 288: 30495-501. PMID 24025330 DOI: 10.1074/Jbc.M113.499004 |
0.361 |
|
| 2013 |
Barthet G, Dunys J, Shao Z, Xuan Z, Ren Y, Xu J, Arbez N, Mauger G, Bruban J, Georgakopoulos A, Shioi J, Robakis NK. Presenilin mediates neuroprotective functions of ephrinB and brain-derived neurotrophic factor and regulates ligand-induced internalization and metabolism of EphB2 and TrkB receptors. Neurobiology of Aging. 34: 499-510. PMID 22475621 DOI: 10.1016/J.Neurobiolaging.2012.02.024 |
0.408 |
|
| 2012 |
Barthet G, Georgakopoulos A, Robakis NK. Cellular mechanisms of γ-secretase substrate selection, processing and toxicity. Progress in Neurobiology. 98: 166-75. PMID 22622135 DOI: 10.1016/J.Pneurobio.2012.05.006 |
0.358 |
|
| 2011 |
Georgakopoulos A, Xu J, Xu C, Mauger G, Barthet G, Robakis NK. Presenilin1/gamma-secretase promotes the EphB2-induced phosphorylation of ephrinB2 by regulating phosphoprotein associated with glycosphingolipid-enriched microdomains/Csk binding protein. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 3594-604. PMID 21746865 DOI: 10.1096/Fj.11-187856 |
0.45 |
|
| 2011 |
Michailidis IE, Rusinova R, Georgakopoulos A, Chen Y, Iyengar R, Robakis NK, Logothetis DE, Baki L. Phosphatidylinositol-4,5-bisphosphate regulates epidermal growth factor receptor activation. Pflã¼Gers Archiv : European Journal of Physiology. 461: 387-97. PMID 21107857 DOI: 10.1007/S00424-010-0904-3 |
0.328 |
|
| 2009 |
Xu J, Litterst C, Georgakopoulos A, Zaganas I, Robakis NK. Peptide EphB2/CTF2 generated by the gamma-secretase processing of EphB2 receptor promotes tyrosine phosphorylation and cell surface localization of N-methyl-D-aspartate receptors. The Journal of Biological Chemistry. 284: 27220-8. PMID 19661068 DOI: 10.1074/Jbc.M109.048728 |
0.41 |
|
| 2009 |
Kouchi Z, Barthet G, Serban G, Georgakopoulos A, Shioi J, Robakis NK. p120 catenin recruits cadherins to gamma-secretase and inhibits production of Abeta peptide. The Journal of Biological Chemistry. 284: 1954-61. PMID 19008223 DOI: 10.1074/Jbc.M806250200 |
0.414 |
|
| 2009 |
Georgakopoulos A. Gamma-secretase promotes the ephrinB-mediated angiogenesis Alzheimers & Dementia. 5: 317. DOI: 10.1016/J.Jalz.2009.04.505 |
0.305 |
|
| 2008 |
Baki L, Neve RL, Shao Z, Shioi J, Georgakopoulos A, Robakis NK. Wild-type but not FAD mutant presenilin-1 prevents neuronal degeneration by promoting phosphatidylinositol 3-kinase neuroprotective signaling. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 483-90. PMID 18184791 DOI: 10.1523/Jneurosci.4067-07.2008 |
0.396 |
|
| 2008 |
Baki L, Neve RL, Shao Z, Shioi J, Georgakopoulos A, Robakis NK. P4-195: Presenilin1 prevents neurodegeneration by stimulating PI3K/Akt neuroprotective signaling: Effects of PS1 familial Alzheimer's disease mutations Alzheimer's & Dementia. 4: T728-T728. DOI: 10.1016/J.Jalz.2008.05.2262 |
0.312 |
|
| 2007 |
Litterst C, Georgakopoulos A, Shioi J, Ghersi E, Wisniewski T, Wang R, Ludwig A, Robakis NK. Ligand binding and calcium influx induce distinct ectodomain/gamma-secretase-processing pathways of EphB2 receptor. The Journal of Biological Chemistry. 282: 16155-63. PMID 17428795 DOI: 10.1074/Jbc.M611449200 |
0.389 |
|
| 2007 |
Shioi J, Georgakopoulos A, Mehta P, Kouchi Z, Litterst CM, Baki L, Robakis NK. FAD mutants unable to increase neurotoxic Abeta 42 suggest that mutation effects on neurodegeneration may be independent of effects on Abeta. Journal of Neurochemistry. 101: 674-81. PMID 17254019 DOI: 10.1111/J.1471-4159.2006.04391.X |
0.304 |
|
| 2006 |
Georgakopoulos A, Litterst C, Ghersi E, Baki L, Xu C, Serban G, Robakis NK. Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signaling. The Embo Journal. 25: 1242-52. PMID 16511561 DOI: 10.1038/Sj.Emboj.7601031 |
0.413 |
|
| 2005 |
Serban G, Kouchi Z, Baki L, Georgakopoulos A, Litterst CM, Shioi J, Robakis NK. Cadherins mediate both the association between PS1 and beta-catenin and the effects of PS1 on beta-catenin stability. The Journal of Biological Chemistry. 280: 36007-12. PMID 16126725 DOI: 10.1074/Jbc.M507503200 |
0.323 |
|
| 2002 |
Marambaud P, Shioi J, Serban G, Georgakopoulos A, Sarner S, Nagy V, Baki L, Wen P, Efthimiopoulos S, Shao Z, Wisniewski T, Robakis NK. A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions. The Embo Journal. 21: 1948-56. PMID 11953314 DOI: 10.1093/Emboj/21.8.1948 |
0.344 |
|
| 2001 |
Baki L, Marambaud P, Efthimiopoulos S, Georgakopoulos A, Wen P, Cui W, Shioi J, Koo E, Ozawa M, Friedrich VL, Robakis NK. Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex. Proceedings of the National Academy of Sciences of the United States of America. 98: 2381-6. PMID 11226248 DOI: 10.1073/Pnas.041603398 |
0.368 |
|
| 1999 |
Georgakopoulos A, Marambaud P, Efthimiopoulos S, Shioi J, Cui W, Li HC, Schütte M, Gordon R, Holstein GR, Martinelli G, Mehta P, Friedrich VL, Robakis NK. Presenilin-1 forms complexes with the cadherin/catenin cell-cell adhesion system and is recruited to intercellular and synaptic contacts. Molecular Cell. 4: 893-902. PMID 10635315 DOI: 10.1016/S1097-2765(00)80219-1 |
0.347 |
|
| 1998 |
Efthimiopoulos S, Floor E, Georgakopoulos A, Shioi J, Cui W, Yasothornsrikul S, Hook VY, Wisniewski T, Buee L, Robakis NK. Enrichment of presenilin 1 peptides in neuronal large dense-core and somatodendritic clathrin-coated vesicles. Journal of Neurochemistry. 71: 2365-72. PMID 9832134 DOI: 10.1046/J.1471-4159.1998.71062365.X |
0.347 |
|
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