Ken J. Kellar - Related publications

Georgetown University, Washington, DC 
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50 most relevant papers in past 60 days:
Year Citation  Score
2021 Hahn B. Cross-species evidence that nicotine widens the attentional window. Psychopharmacology. PMID 34618202 DOI: 10.1007/s00213-021-05972-y   
2021 Rosenthal JS, Yuan Q. Constructing and Tuning Excitatory Cholinergic Synapses: The Multifaceted Functions of Nicotinic Acetylcholine Receptors in Neural Development and Physiology. Frontiers in Cellular Neuroscience. 15: 720560. PMID 34650404 DOI: 10.3389/fncel.2021.720560   
2021 Loser D, Grillberger K, Hinojosa MG, Blum J, Haufe Y, Danker T, Johansson Y, Möller C, Nicke A, Bennekou SH, Gardner I, Bauch C, Walker P, Forsby A, Ecker GF, et al. Acute effects of the imidacloprid metabolite desnitro-imidacloprid on human nACh receptors relevant for neuronal signaling. Archives of Toxicology. PMID 34628512 DOI: 10.1007/s00204-021-03168-z   
2021 Wei N, Chu Y, Liu H, Xu Q, Jiang T, Yu R. Antagonistic Mechanism of α-Conotoxin BuIA toward the Human α3β2 Nicotinic Acetylcholine Receptor. Acs Chemical Neuroscience. PMID 34738810 DOI: 10.1021/acschemneuro.1c00568   
2021 Gallagher R, Qudah T, Balle T, Chebib M, McLeod MD. Novel methyllycaconitine analogues selective for the α4β2 over α7 nicotinic acetylcholine receptors. Bioorganic & Medicinal Chemistry. 51: 116516. PMID 34798380 DOI: 10.1016/j.bmc.2021.116516   
2021 Liu Q, Yu J, Li X, Guo Y, Sun T, Luo L, Ren J, Jiang W, Zhang R, Yang P, Yang Q. Cannabinoid receptor GPR55 activation blocks nicotine use disorder by regulation of AMPAR phosphorylation. Psychopharmacology. PMID 34648060 DOI: 10.1007/s00213-021-05949-x   
2021 Peters K, Dahlgren D, Lennernäs H, Sjöblom M. Melatonin-Activated Receptor Signaling Pathways Mediate Protective Effects on Surfactant-Induced Increase in Jejunal Mucosal Permeability in Rats. International Journal of Molecular Sciences. 22. PMID 34639101 DOI: 10.3390/ijms221910762   
2021 Christesen D, Yang YT, Chen W, Batterham P, Perry T. Loss of the Dβ1 nicotinic acetylcholine receptor subunit disrupts bursicon-driven wing expansion and diminishes adult viability in Drosophila melanogaster. Genetics. 219. PMID 34849910 DOI: 10.1093/genetics/iyab112   
2021 Shinde AK, Badange RK, Reballi V, Achanta PK, Bojja K, Manchineella S, Rao Muddana N, Subramanian R, Choudary Palacharla R, Benade V, Jayarajan P, Thentu JB, Lingavarapu BB, Yarra S, Kagita N, et al. 1-[2-(1-Cyclobutylpiperidin-4-yloxy)-6,7-dihydro-4H-thiazolo[5,4-c]pyridin-5-yl]propan-1-one: a Histamine H Receptor Inverse Agonist with Efficacy in Animal Models of Cognition. Chemmedchem. PMID 34761873 DOI: 10.1002/cmdc.202100583   
2021 Khan SA, Zia K, Ashraf S, Khan A, Ul-Haq Z. Theoretical investigation of selective ligand binding mode of galanin receptors. Journal of Biomolecular Structure & Dynamics. 1-11. PMID 34632940 DOI: 10.1080/07391102.2021.1977703   
2021 Wang M, Hou S, Liu Y, Li D, Lin J. Identification of Novel Antagonists Targeting Cannabinoid Receptor 2 Using a Multi-Step Virtual Screening Strategy. Molecules (Basel, Switzerland). 26. PMID 34771087 DOI: 10.3390/molecules26216679   
2021 Liu T, Yi TL, Yang DQ, Tao YX. Regulation of melanocortin-5 receptor pharmacology by two isoforms of MRAP2 in ricefield eel (Monopterus albus). General and Comparative Endocrinology. 113928. PMID 34653433 DOI: 10.1016/j.ygcen.2021.113928   
2021 Jurutka PW, di Martino O, Reshi S, Mallick S, Sabir ZL, Staniszewski LJP, Warda A, Maiorella EL, Minasian A, Davidson J, Ibrahim SJ, Raban S, Haddad D, Khamisi M, Suban SL, et al. Modeling, Synthesis, and Biological Evaluation of Potential Retinoid-X-Receptor (RXR) Selective Agonists: Analogs of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahyro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) and 6-(Ethyl(4-isobutoxy-3-isopropylphenyl)amino)nicotinic Acid (NEt-4IB). International Journal of Molecular Sciences. 22. PMID 34830251 DOI: 10.3390/ijms222212371   
2021 Raïch I, Rivas-Santisteban R, Lillo A, Lillo J, Reyes-Resina I, Nadal X, Ferreiro-Vera C, de Medina VS, Majellaro M, Sotelo E, Navarro G, Franco R. Similarities and differences upon binding of naturally occurring Δ-tetrahydrocannabinol-derivatives to cannabinoid CB and CB receptors. Pharmacological Research. 174: 105970. PMID 34758399 DOI: 10.1016/j.phrs.2021.105970   
2021 Patberg M, Isaak A, Füsser F, Ortiz Zacarías NV, Vinnenberg L, Schulte J, Michetti L, Grey L, van der Horst C, Hundehege P, Koch O, Heitman LH, Budde T, Junker A. Piperazine squaric acid diamides, a novel class of allosteric P2X7 receptor antagonists. European Journal of Medicinal Chemistry. 226: 113838. PMID 34571173 DOI: 10.1016/j.ejmech.2021.113838   
2021 Lou L, Li C, Wang J, Wu A, Zhang T, Ma Z, Chai L, Zhang D, Zhao Y, Nie B, Jin Q, Chen H, Liu WJ. Yiqi Huoxue preserves heart function by upregulating the Sigma-1 receptor in rats with myocardial infarction. Experimental and Therapeutic Medicine. 22: 1308. PMID 34630662 DOI: 10.3892/etm.2021.10743   
2021 Long S, Ji S, Xiao K, Xue P, Zhu S. Prognostic and immunological value of LTB4R in pan-cancer. Mathematical Biosciences and Engineering : Mbe. 18: 9336-9356. PMID 34814348 DOI: 10.3934/mbe.2021459   
2021 Matsushita Y, Manabe M, Kitagawa I, Higuchi M, Hosaka YZ, Kitamura N. Inhibition of transient receptor potential vanilloid type 1 through α adrenergic receptors at peripheral nerve terminals relieves pain. The Journal of Veterinary Medical Science. 83: 1570-1581. PMID 34470979 DOI: 10.1292/jvms.21-0429   
2021 Okita K, Kato K, Shigemoto Y, Sato N, Matsumoto T, Matsuda H. Effects of an Adenosine A Receptor Antagonist on Striatal Dopamine D2-Type Receptor Availability: A Randomized Control Study Using Positron Emission Tomography. Frontiers in Neuroscience. 15: 729153. PMID 34588952 DOI: 10.3389/fnins.2021.729153   
2021 Zhou Y, Zhou M, Qi Y, Wang W, Chen X, Wang S. The prognostic value of thyroid-stimulating immunoglobulin in the management of Graves' disease. Therapeutic Advances in Endocrinology and Metabolism. 12: 20420188211044943. PMID 34603682 DOI: 10.1177/20420188211044943   
2021 Sapkota K, Burnell ES, Irvine MW, Fang G, Gawande DY, Dravid SM, Jane DE, Monaghan DT. Pharmacological characterization of a novel negative allosteric modulator of NMDA receptors, UBP792. Neuropharmacology. 201: 108818. PMID 34610288 DOI: 10.1016/j.neuropharm.2021.108818   
2021 Ishida A, Okabe Y, Matsushita T, Sekiguchi T, Nishio T, Komagata T, Iwaki M, Miyata H, Katagi J, Naganawa A, Maruyama T, Imagawa A. Design, synthesis, and biological evaluation of novel somatostatin receptor subtype-2 agonists: Optimization for potency and risk mitigation of hERG and phospholipidosis. Bioorganic & Medicinal Chemistry. 49: 116424. PMID 34626901 DOI: 10.1016/j.bmc.2021.116424   
2021 Fouad Shalaby MA, Abd El Latif HA, El Yamani M, Galal MA, Kamal S, Sindi I, Masaood R. Therapeutic activity of sarpogrelate and dopamine D receptor agonists on cardiovascular and renal systems in rats with alloxan-induced diabetes. Bmc Pharmacology & Toxicology. 22: 64. PMID 34702339 DOI: 10.1186/s40360-021-00526-6   
2021 Zarkin A, Jahan R, Uprety R, Zhang Y, McElhinny C, Snyder R, Gay E, Jewula G, Bool H, Clark SD, Runyon S. Identification of a Novel Neuropeptide S Receptor Antagonist Scaffold Based on the SHA-68 Core. Pharmaceuticals (Basel, Switzerland). 14. PMID 34681248 DOI: 10.3390/ph14101024   
2021 Jenkins L, Marsango S, Mancini S, Mahmud ZA, Morrison A, McElroy SP, Bennett KA, Barnes M, Tobin AB, Tikhonova IG, Milligan G. Discovery and Characterization of Novel Antagonists of the Proinflammatory Orphan Receptor GPR84. Acs Pharmacology & Translational Science. 4: 1598-1613. PMID 34661077 DOI: 10.1021/acsptsci.1c00151   
2021 Mann G, Kadiyala KG, Thirumal M, Tiwari AK, Datta A. Receptor mapping using methoxy phenyl piperazine derivative: Preclinical PET imaging. Bioorganic Chemistry. 117: 105429. PMID 34736134 DOI: 10.1016/j.bioorg.2021.105429   
2021 Cheng X, Yin C, Deng Y, Li Z. Exogenous adenosine activates A2A adenosine receptor to inhibit RANKL-induced osteoclastogenesis via AP-1 pathway to facilitate bone repair. Molecular Biology Reports. PMID 34846650 DOI: 10.1007/s11033-021-07017-1   
2021 Baldwin SN, Forrester EA, McEwan L, Greenwood IA. Sexual dimorphism in prostacyclin-mimetic responses within rat mesenteric arteries: A novel role for K 7.1 in shaping IP-receptor mediated relaxation. British Journal of Pharmacology. PMID 34766649 DOI: 10.1111/bph.15722   
2021 Howlett AC, Thomas BF, Huffman JW. The Spicy Story of Cannabimimetic Indoles. Molecules (Basel, Switzerland). 26. PMID 34684770 DOI: 10.3390/molecules26206190   
2021 Cai X, Yao Y, Teng F, Li Y, Wu L, Yan W, Lin N. The role of P2X7 receptor in infection and metabolism: Based on inflammation and immunity. International Immunopharmacology. 101: 108297. PMID 34717202 DOI: 10.1016/j.intimp.2021.108297   
2021 Bender AM, Carter TR, Spock M, Rodriguez AL, Dickerson JW, Rook JM, Chang S, Qi A, Presley CC, Engers DW, Harp JM, Bridges TM, Niswender CM, Conn PJ, Lindsley CW. Synthesis and Characterization of Chiral 6-Azaspiro[2.5]Octanes as Potent and Selective Antagonists of the M Muscarinic Acetylcholine Receptor. Bioorganic & Medicinal Chemistry Letters. 128479. PMID 34838649 DOI: 10.1016/j.bmcl.2021.128479   
2021 Hansen KB, Wollmuth LP, Bowie D, Furukawa H, Menniti FS, Sobolevsky AI, Swanson GT, Swanger SA, Greger IH, Nakagawa T, McBain CJ, Jayaraman V, Low CM, Dell'Acqua ML, Diamond JS, et al. Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels. Pharmacological Reviews. 73: 298-487. PMID 34753794 DOI: 10.1124/pharmrev.120.000131   
2021 Wines BD, Trist HM, Esparon S, Impey RE, Mackay GA, Andrews RK, Soares da Costa TP, Pietersz GA, Baker RI, Hogarth PM. Fc Binding by FcγRIIa Is Essential for Cellular Activation by the Anti-FcγRIIa mAbs 8.26 and 8.2. Frontiers in Immunology. 12: 666813. PMID 34759915 DOI: 10.3389/fimmu.2021.666813   
2021 Brockett AT, Deng C, Shuster M, Perera S, DiMaggio D, Cheng M, Murkli S, Briken V, Roesch MR, Isaacs L. In Vitro and In Vivo Sequestration of Methamphetamine by a Sulfated Acyclic CB[n]-Type Receptor. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 34613641 DOI: 10.1002/chem.202102919   
2021 Wang J, Miao Y, Wicklein R, Sun Z, Wang J, Jude KM, Fernandes RA, Merrill SA, Wernig M, Garcia KC, Südhof TC. RTN4/NoGo-receptor binding to BAI adhesion-GPCRs regulates neuronal development. Cell. PMID 34758294 DOI: 10.1016/j.cell.2021.10.016   
2021 Rečnik LM, Thatcher RJ, Mallah S, Butts CP, Collingridge GL, Molnár E, Jane DE, Willis CL. Synthesis and pharmacological characterisation of arctigenin analogues as antagonists of AMPA and kainate receptors. Organic & Biomolecular Chemistry. 19: 9154-9162. PMID 34642722 DOI: 10.1039/d1ob01653a   
2021 Kai H, Horiguchi T, Kameyma T, Onodera N, Itoh N, Fujii Y, Ichihashi Y, Hirai K, Shintani T, Nakamura K, Minami K, Kasai E, Yoneda S, Murakami Y, Ogawa H, et al. Discovery of clinical candidate Sivopixant (S-600918): Lead optimization of dioxotriazine derivatives as selective P2X3 receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 52: 128384. PMID 34587541 DOI: 10.1016/j.bmcl.2021.128384   
2021 Gao J, Yuan X, Zheng X, Zhao X, Wang T, Liang Q, Xiao C, Wang J, Li Q, Zhao X. Two-point immobilization of a conformation-specific beta-adrenoceptor for recognizing the receptor agonists or antagonists inspired by binding-induced DNA assembly. Biomaterials Science. PMID 34704989 DOI: 10.1039/d1bm01222c   
2021 Faúndez-Parraguez M, Alarcón-Miranda C, Cho YH, Pessoa-Mahana H, Gallardo-Garrido C, Chung H, Faúndez M, Pessoa-Mahana D. New Pyridone-Based Derivatives as Cannabinoid Receptor Type 2 Agonists. International Journal of Molecular Sciences. 22. PMID 34681877 DOI: 10.3390/ijms222011212   
2021 Levick SP. Histamine receptors in heart failure. Heart Failure Reviews. PMID 34622365 DOI: 10.1007/s10741-021-10166-x   
2021 Hinds CE, Owen BM, Hope DCD, Pickford P, Jones B, Tan TM, Minnion JS, Bloom SR. A glucagon analogue decreases body weight in mice via signalling in the liver. Scientific Reports. 11: 22577. PMID 34799628 DOI: 10.1038/s41598-021-01912-0   
2021 Xu Q, Hu M, Li J, Ma X, Chu Z, Zhu Q, Zhang Y, Zhu P, Huang Y, He G. Discovery of novel brain-penetrant GluN2B NMDAR antagonists via pharmacophore-merging strategy as anti-stroke therapeutic agents. European Journal of Medicinal Chemistry. 227: 113876. PMID 34710748 DOI: 10.1016/j.ejmech.2021.113876   
2021 Bachurin SO, Makhaeva GF, Shevtsova EF, Aksinenko AY, Grigoriev VV, Shevtsov PN, Goreva TV, Epishina TA, Kovaleva NV, Pushkareva EA, Boltneva NP, Lushchekina SV, Gabrelyan AV, Zamoyski VL, Dubova LG, et al. Conjugation of Aminoadamantane and γ-Carboline Pharmacophores Gives Rise to Unexpected Properties of Multifunctional Ligands. Molecules (Basel, Switzerland). 26. PMID 34576998 DOI: 10.3390/molecules26185527   
2021 Suresh M, Li B, Huang X, Korolowicz KE, Murreddu MG, Gudima SO, Menne S. Agonistic Activation of Cytosolic DNA Sensing Receptors in Woodchuck Hepatocyte Cultures and Liver for Inducing Antiviral Effects. Frontiers in Immunology. 12: 745802. PMID 34671360 DOI: 10.3389/fimmu.2021.745802   
2021 Hong J, Kwon HJ, Cachau R, Chen CZ, Butay KJ, Duan Z, Li D, Ren H, Liang T, Zhu J, Dandey VP, Martin N, Esposito D, Ortega-Rodriguez U, Xu M, et al. Camel nanobodies broadly neutralize SARS-CoV-2 variants. Biorxiv : the Preprint Server For Biology. PMID 34751270 DOI: 10.1101/2021.10.27.465996   
2021 Liang Q, Joshi S, Liu H, Yu Y, Zhao H, Benzinger TLS, Perlmutter JS, Tu Z. In vitro characterization of [H]VAT in cells, animal and human brain tissues for vesicular acetylcholine transporter. European Journal of Pharmacology. 911: 174556. PMID 34627806 DOI: 10.1016/j.ejphar.2021.174556   
2021 Arora A, Behl T, Sehgal A, Singh S, Sharma N, Chigurupati S, Kaur R, Bhatia S, Al-Harrasi A, Vargas-De-La-Cruz C, Bungau S. Free fatty acid receptor 1: a ray of hope in the therapy of type 2 diabetes mellitus. Inflammopharmacology. PMID 34669065 DOI: 10.1007/s10787-021-00879-8   
2021 Lee R, Choi SH, Cho HS, Hwang H, Rhim H, Kim HC, Hwang SH, Nah SY. Effect of the Gintonin-Enriched Fraction on Glucagon-Like-Protein-1 Release. Molecules (Basel, Switzerland). 26. PMID 34684879 DOI: 10.3390/molecules26206298   
2021 Dodd J, Jordan R, Makhlina M, Pesco Koplowitz L, Koplowitz B, Barnett K, Yang WH, Spana C. Pharmacokinetics of the Melanocortin Type 1 Receptor Agonist PL8177 After Subcutaneous Administration. Drugs in R&D. PMID 34693509 DOI: 10.1007/s40268-021-00367-y   
2021 Song Y, Deng X, Shi W, Tang F, Huang W, Gong L, Qin Q. A homogeneous time-resolved fluorometric energy transfer assay for the binding assessment of FcRn with IgG antibodies. Journal of Immunological Methods. 113180. PMID 34736962 DOI: 10.1016/j.jim.2021.113180