Jan Lewerenz, MD - Publications

Affiliations: 
Neurology University of Ulm, Ulm, Baden-Württemberg, Germany 

51 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Schubert J, Brämer D, Huttner HB, Gerner ST, Fuhrer H, Melzer N, Dik A, Prüss H, Ly LT, Fuchs K, Leypoldt F, Nissen G, Schirotzek I, Dohmen C, Bösel J, ... Lewerenz J, et al. Management and prognostic markers in patients with autoimmune encephalitis requiring ICU treatment. Neurology(R) Neuroimmunology & Neuroinflammation. 6: e514. PMID 30568992 DOI: 10.1212/NXI.0000000000000514  1
2018 Baumgartner A, Rauer S, Hottenrott T, Leypoldt F, Ufer F, Hegen H, Prüss H, Lewerenz J, Deisenhammer F, Stich O. Admission diagnoses of patients later diagnosed with autoimmune encephalitis. Journal of Neurology. PMID 30421340 DOI: 10.1007/s00415-018-9105-3  1
2018 Lewerenz J, Ates G, Methner A, Conrad M, Maher P. Oxytosis/Ferroptosis-(Re-) Emerging Roles for Oxidative Stress-Dependent Non-apoptotic Cell Death in Diseases of the Central Nervous System. Frontiers in Neuroscience. 12: 214. PMID 29731704 DOI: 10.3389/fnins.2018.00214  1
2018 Mueller SH, Färber A, Prüss H, Melzer N, Golombeck KS, Kümpfel T, Thaler F, Elisak M, Lewerenz J, Kaufmann M, Sühs KW, Ringelstein M, Kellinghaus C, Bien CG, Kraft A, et al. Genetic predisposition in anti-LGI1 and anti-NMDA receptor encephalitis. Annals of Neurology. PMID 29572931 DOI: 10.1002/ana.25216  1
2017 Pfeiffer A, Schneider J, Bueno D, Dolga A, Voss TD, Lewerenz J, Wüllner V, Methner A. Bcl-xL knockout attenuates mitochondrial respiration and causes oxidative stress that is compensated by pentose phosphate pathway activity. Free Radical Biology & Medicine. PMID 28807815 DOI: 10.1016/j.freeradbiomed.2017.08.007  1
2017 Merckx E, Albertini G, Paterka M, Jensen C, Albrecht P, Dietrich M, Van Liefferinge J, Bentea E, Verbruggen L, Demuyser T, Deneyer L, Lewerenz J, van Loo G, De Keyser J, Sato H, et al. Absence of system xc(-) on immune cells invading the central nervous system alleviates experimental autoimmune encephalitis. Journal of Neuroinflammation. 14: 9. PMID 28086920 DOI: 10.1186/s12974-016-0787-0  1
2016 Bentea E, Van Liefferinge J, Verbruggen L, Martens K, Kobayashi S, Deneyer L, Demuyser T, Albertini G, Maes K, Sato H, Smolders I, Lewerenz J, Massie A. Zonisamide attenuates lactacystin-induced parkinsonism in mice without affecting system xc. Experimental Neurology. PMID 28024798 DOI: 10.1016/j.expneurol.2016.12.009  0.48
2015 Lewerenz J, Maher P. Chronic Glutamate Toxicity in Neurodegenerative Diseases-What is the Evidence? Frontiers in Neuroscience. 9: 469. PMID 26733784 DOI: 10.3389/fnins.2015.00469  1
2015 Fauser S, Uttner I, Ariño H, Scherbaum WA, Saiz A, Lewerenz J. Long latency between GAD-antibody detection and development of limbic encephalitis - a case report. Bmc Neurology. 15: 177. PMID 26420440 DOI: 10.1186/s12883-015-0435-9  1
2015 Massie A, Boillée S, Hewett S, Knackstedt L, Lewerenz J. Main path and byways: non-vesicular glutamate release by system xc (-) as an important modifier of glutamatergic neurotransmission. Journal of Neurochemistry. PMID 26336934 DOI: 10.1111/jnc.13348  1
2015 Gahr M, Lauda F, Wigand ME, Connemann BJ, Rosenbohm A, Tumani H, Reindl M, Uzelac Z, Lewerenz J. Periventricular white matter lesion and incomplete MRZ reaction in a male patient with anti-N-methyl-D-aspartate receptor encephalitis presenting with dysphoric mania. Bmj Case Reports. 2015. PMID 25917068 DOI: 10.1136/bcr-2014-209075  1
2015 Hawlik A, Wassner A, Ludolph AC, Lewerenz J, Rosenbohm A. Internalized capillaries in skeletal muscle biopsy. Neuromuscular Disorders : Nmd. 25: 94-5. PMID 25307855 DOI: 10.1016/j.nmd.2014.08.005  1
2015 Urbach H, Rauer S, Mader I, Paus S, Wagner J, Malter MP, Prüss H, Lewerenz J, Kassubek J, Hegen H, Auer M, Deisenhammer F, Ufer F, Bien CG, Baumgartner A. Supratentorial white matter blurring associated with voltage-gated potassium channel-complex limbic encephalitis Neuroradiology. DOI: 10.1007/s00234-015-1581-x  1
2015 Lewerenz J, Leypoldt F. Paraneoplastic neurological syndromes Cerebrospinal Fluid in Clinical Neurology. 353-385. DOI: 10.1007/978-3-319-01225-4_21  1
2014 Sabater L, Gaig C, Gelpi E, Bataller L, Lewerenz J, Torres-Vega E, Contreras A, Giometto B, Compta Y, Embid C, Vilaseca I, Iranzo A, Santamaría J, Dalmau J, Graus F. A novel non-rapid-eye movement and rapid-eye-movement parasomnia with sleep breathing disorder associated with antibodies to IgLON5: a case series, characterisation of the antigen, and post-mortem study. The Lancet. Neurology. 13: 575-86. PMID 24703753 DOI: 10.1016/S1474-4422(14)70051-1  1
2014 Pfeiffer A, Jaeckel M, Lewerenz J, Noack R, Pouya A, Schacht T, Hoffmann C, Winter J, Schweiger S, Schäfer MK, Methner A. Mitochondrial function and energy metabolism in neuronal HT22 cells resistant to oxidative stress. British Journal of Pharmacology. 171: 2147-58. PMID 24319993 DOI: 10.1111/bph.12549  1
2014 Lewerenz J, Baxter P, Kassubek R, Albrecht P, Van Liefferinge J, Westhoff MA, Halatsch ME, Karpel-Massler G, Meakin PJ, Hayes JD, Aronica E, Smolders I, Ludolph AC, Methner A, Conrad M, et al. Phosphoinositide 3-kinases upregulate system xc(-) via eukaryotic initiation factor 2α and activating transcription factor 4 - A pathway active in glioblastomas and epilepsy. Antioxidants & Redox Signaling. 20: 2907-22. PMID 24219064 DOI: 10.1089/ars.2013.5455  1
2013 Wiesner D, Merdian I, Lewerenz J, Ludolph AC, Dupuis L, Witting A. Fumaric acid esters stimulate astrocytic VEGF expression through HIF-1α and Nrf2. Plos One. 8: e76670. PMID 24098549 DOI: 10.1371/journal.pone.0076670  1
2013 Süssmuth SD, Brettschneider J, Spreer A, Wick M, Jesse S, Lewerenz J, Otto M, Tumani H. [Current cerebrospinal fluid diagnostics for pathogen-related diseases]. Der Nervenarzt. 84: 229-44. PMID 23371378 DOI: 10.1007/s00115-012-3701-8  1
2013 Albrecht P, Henke N, Tien ML, Issberner A, Bouchachia I, Maher P, Lewerenz J, Methner A. Extracellular cyclic GMP and its derivatives GMP and guanosine protect from oxidative glutamate toxicity. Neurochemistry International. 62: 610-9. PMID 23357478 DOI: 10.1016/j.neuint.2013.01.019  1
2013 Henke N, Albrecht P, Bouchachia I, Ryazantseva M, Knoll K, Lewerenz J, Kaznacheyeva E, Maher P, Methner A. The plasma membrane channel ORAI1 mediates detrimental calcium influx caused by endogenous oxidative stress. Cell Death & Disease. 4: e470. PMID 23348584 DOI: 10.1038/cddis.2012.216  1
2013 Lewerenz J, Hewett SJ, Huang Y, Lambros M, Gout PW, Kalivas PW, Massie A, Smolders I, Methner A, Pergande M, Smith SB, Ganapathy V, Maher P. The cystine/glutamate antiporter system x(c)(-) in health and disease: from molecular mechanisms to novel therapeutic opportunities. Antioxidants & Redox Signaling. 18: 522-55. PMID 22667998 DOI: 10.1089/ars.2011.4391  1
2012 Albrecht P, Bouchachia I, Goebels N, Henke N, Hofstetter HH, Issberner A, Kovacs Z, Lewerenz J, Lisak D, Maher P, Mausberg AK, Quasthoff K, Zimmermann C, Hartung HP, Methner A. Effects of dimethyl fumarate on neuroprotection and immunomodulation. Journal of Neuroinflammation. 9: 163. PMID 22769044 DOI: 10.1186/1742-2094-9-163  1
2012 Leypoldt F, Buchert R, Kleiter I, Marienhagen J, Gelderblom M, Magnus T, Dalmau J, Gerloff C, Lewerenz J. Fluorodeoxyglucose positron emission tomography in anti-N-methyl-D-aspartate receptor encephalitis: distinct pattern of disease. Journal of Neurology, Neurosurgery, and Psychiatry. 83: 681-6. PMID 22566598 DOI: 10.1136/jnnp-2011-301969  1
2012 Gelderblom M, Leypoldt F, Lewerenz J, Birkenmayer G, Orozco D, Ludewig P, Thundyil J, Arumugam TV, Gerloff C, Tolosa E, Maher P, Magnus T. The flavonoid fisetin attenuates postischemic immune cell infiltration, activation and infarct size after transient cerebral middle artery occlusion in mice. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 32: 835-43. PMID 22234339 DOI: 10.1038/jcbfm.2011.189  1
2012 Lewerenz J, Sato H, Albrecht P, Henke N, Noack R, Methner A, Maher P. Mutation of ATF4 mediates resistance of neuronal cell lines against oxidative stress by inducing xCT expression. Cell Death and Differentiation. 19: 847-58. PMID 22095285 DOI: 10.1038/cdd.2011.165  1
2012 Noack R, Frede S, Albrecht P, Henke N, Pfeiffer A, Knoll K, Dehmel T, Meyer Zu Hörste G, Stettner M, Kieseier BC, Summer H, Golz S, Kochanski A, Wiedau-Pazos M, Arnold S, ... Lewerenz J, et al. Charcot-Marie-Tooth disease CMT4A: GDAP1 increases cellular glutathione and the mitochondrial membrane potential. Human Molecular Genetics. 21: 150-62. PMID 21965300 DOI: 10.1093/hmg/ddr450  1
2012 Lewerenz J, Maher P, Methner A. Regulation of xCT expression and system x (c) (-) function in neuronal cells. Amino Acids. 42: 171-9. PMID 21369940 DOI: 10.1007/s00726-011-0862-x  1
2011 Bartlett BJ, Isakson P, Lewerenz J, Sanchez H, Kotzebue RW, Cumming RC, Harris GL, Nezis IP, Schubert DR, Simonsen A, Finley KD. p62, Ref(2)P and ubiquitinated proteins are conserved markers of neuronal aging, aggregate formation and progressive autophagic defects. Autophagy. 7: 572-83. PMID 21325881 DOI: 10.4161/auto.7.6.14943  1
2011 Choe CU, Lewerenz J, Gerloff C, Magnus T, Donzelli S. Nitroxyl in the central nervous system. Antioxidants & Redox Signaling. 14: 1699-711. PMID 21235347 DOI: 10.1089/ars.2010.3852  1
2011 Lewerenz J, Maher P. Control of redox state and redox signaling by neural antioxidant systems. Antioxidants & Redox Signaling. 14: 1449-65. PMID 20812872 DOI: 10.1089/ars.2010.3600  1
2010 Lewerenz J, Dargusch R, Maher P. Lactacidosis modulates glutathione metabolism and oxidative glutamate toxicity. Journal of Neurochemistry. 113: 502-14. PMID 20132475 DOI: 10.1111/j.1471-4159.2010.06621.x  1
2010 Albrecht P, Lewerenz J, Dittmer S, Noack R, Maher P, Methner A. Mechanisms of oxidative glutamate toxicity: the glutamate/cystine antiporter system xc- as a neuroprotective drug target. Cns & Neurological Disorders Drug Targets. 9: 373-82. PMID 20053169  1
2010 Toutzaris D, Lewerenz J, Albrecht P, Jensen LT, Letz J, Geerts A, Golz S, Methner A. A novel giant peroxisomal superoxide dismutase motif-containing protein. Free Radical Biology & Medicine. 48: 811-20. PMID 20045724 DOI: 10.1016/j.freeradbiomed.2009.12.023  1
2009 Lewerenz J, Ding XQ, Matschke J, Schnabel C, Emami P, von Borczyskowski D, Buchert R, Krieger T, de Wit M, Münchau A. Dementia and leukoencephalopathy due to lymphomatosis cerebri. Bmj Case Reports. 2009. PMID 21686648 DOI: 10.1136/bcr.08.2008.0752  1
2009 Lewerenz J, Albrecht P, Tien ML, Henke N, Karumbayaram S, Kornblum HI, Wiedau-Pazos M, Schubert D, Maher P, Methner A. Induction of Nrf2 and xCT are involved in the action of the neuroprotective antibiotic ceftriaxone in vitro. Journal of Neurochemistry. 111: 332-43. PMID 19694903 DOI: 10.1111/j.1471-4159.2009.06347.x  1
2009 Choe CU, Lewerenz J, Fischer G, Uliasz TF, Espey MG, Hummel FC, King SB, Schwedhelm E, Böger RH, Gerloff C, Hewett SJ, Magnus T, Donzelli S. Nitroxyl exacerbates ischemic cerebral injury and oxidative neurotoxicity. Journal of Neurochemistry. 110: 1766-73. PMID 19619135 DOI: 10.1111/j.1471-4159.2009.06266.x  1
2009 Lewerenz J, Maher P. Basal levels of eIF2alpha phosphorylation determine cellular antioxidant status by regulating ATF4 and xCT expression. The Journal of Biological Chemistry. 284: 1106-15. PMID 19017641 DOI: 10.1074/jbc.M807325200  1
2008 Maher P, Lewerenz J, Lozano C, Torres JL. A novel approach to enhancing cellular glutathione levels. Journal of Neurochemistry. 107: 690-700. PMID 18702664 DOI: 10.1111/j.1471-4159.2008.05620.x  1
2007 Lewerenz J, Ding X, Matschke J, Schnabel C, Emami P, von Borczyskowski D, Buchert R, Krieger T, de Wit M, Münchau A. Dementia and leukoencephalopathy due to lymphomatosis cerebri. Journal of Neurology, Neurosurgery, and Psychiatry. 78: 777-8. PMID 17210623 DOI: 10.1136/jnnp.2006.106385  1
2006 Sahin M, Saxena A, Joost P, Lewerenz J, Methner A. Induction of Bcl-2 by functional regulation of G-protein coupled receptors protects from oxidative glutamate toxicity by increasing glutathione. Free Radical Research. 40: 1113-23. PMID 17050165 DOI: 10.1080/10715760600838191  1
2006 Leypoldt F, Eichhorn P, Saager C, Münchau A, Lewerenz J. Successful immunosuppressive treatment and long-term follow-up of anti-Ri-associated paraneoplastic myelitis. Journal of Neurology, Neurosurgery, and Psychiatry. 77: 1199-200. PMID 16980662 DOI: 10.1136/jnnp.2005.086140  1
2006 Lewerenz J, Klein M, Methner A. Cooperative action of glutamate transporters and cystine/glutamate antiporter system Xc- protects from oxidative glutamate toxicity. Journal of Neurochemistry. 98: 916-25. PMID 16771835 DOI: 10.1111/j.1471-4159.2006.03921.x  1
2006 Lewerenz J, Methner A. Mechanisms and role of oxidative glutamate toxicity | Mechanismen und Bedeutung der oxidativen Glutamattoxizität Neuroforum. 12: 222-227.  1
2005 Lewerenz J, Zurowski B, Jenicke L, Bäumer T, Lees AJ, Münchau A. Lesion of the dorsorostral midbrain sparing the nigrostriatal tract mimics axial rigidity seen in progressive supranuclear palsy. Movement Disorders : Official Journal of the Movement Disorder Society. 20: 1071-5. PMID 15838851 DOI: 10.1002/mds.20484  1
2003 Lewerenz J, Thomsen S, Steinbeck JA, Methner A. Short-term serum supplementation improves glucose-oxygen deprivation in primary cortical cultures grown under serum-free conditions. Methods in Cell Science : An Official Journal of the Society For in Vitro Biology. 25: 227-36. PMID 15801169  1
2003 Lewerenz J, Gocht A, Hoeger PH, von den Driesch P, Eckert B, Lamszus K, Stuerenburg HJ, Methner A. Multiple vascular abnormalities and a paradoxical combination of vitamin B12 deficiency and thrombocytosis in a case with POEMS syndrome. Journal of Neurology. 250: 1488-91. PMID 14673584 DOI: 10.1007/s00415-003-0261-7  1
2003 Lewerenz J, Letz J, Methner A. Activation of stimulatory heterotrimeric G proteins increases glutathione and protects neuronal cells against oxidative stress. Journal of Neurochemistry. 87: 522-31. PMID 14511129 DOI: 10.1046/j.1471-4159.2003.02019.x  1
2003 Lewerenz J, Leypoldt F, Methner A. Degenerate suppression PCR identifies the beta2-adrenergic receptor as upregulated by neuronal differentiation. Gene Expression. 11: 105-16. PMID 12837041  1
2001 Methner A, Leypoldt F, Joost P, Lewerenz J. Human septin 3 on chromosome 22q13.2 is upregulated by neuronal differentiation. Biochemical and Biophysical Research Communications. 283: 48-56. PMID 11322766 DOI: 10.1006/bbrc.2001.4741  1
2001 Leypoldt F, Lewerenz J, Methner A. Identification of genes up-regulated by retinoic-acid-induced differentiation of the human neuronal precursor cell line NTERA-2 cl.D1. Journal of Neurochemistry. 76: 806-14. PMID 11158252 DOI: 10.1046/j.1471-4159.2001.00079.x  1
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