| Year |
Citation |
Score |
| 2023 |
Smith JW, O'Meally RN, Burke SM, Ng DK, Chen JG, Kensler TW, Groopman JD, Cole RN. Global Discovery and Temporal Changes of Human Albumin Modifications by Pan-Protein Adductomics: Initial Application to Air Pollution Exposure. Journal of the American Society For Mass Spectrometry. PMID 36939690 DOI: 10.1021/jasms.2c00314 |
0.482 |
|
| 2022 |
Smith JW, Ng DK, Alvarez CS, Egner PA, Burke SM, Chen JG, Kensler TW, Koshiol J, Rivera-Andrade A, Kroker-Lobos MF, Ramírez-Zea M, McGlynn KA, Groopman JD. Assessing the Validity of Normalizing Aflatoxin B-Lysine Albumin Adduct Biomarker Measurements to Total Serum Albumin Concentration across Multiple Human Population Studies. Toxins. 14. PMID 35324659 DOI: 10.3390/toxins14030162 |
0.463 |
|
| 2021 |
Smith JW, O'Meally RN, Ng DK, Chen JG, Kensler TW, Cole RN, Groopman JD. Biomonitoring of Ambient Outdoor Air Pollutant Exposure in Humans Using Targeted Serum Albumin Adductomics. Chemical Research in Toxicology. PMID 33793228 DOI: 10.1021/acs.chemrestox.1c00055 |
0.483 |
|
| 2021 |
Chen JG, Zhu J, Zhang YH, Chen YS, Lu JH, Zhu YR, Chen HZ, Shen AG, Wang GR, Groopman JD, Kensler TW. Liver cancer mortality over six decades in an epidemic area: what we have learned. Peerj. 9: e10600. PMID 33604165 DOI: 10.7717/peerj.10600 |
0.462 |
|
| 2020 |
Shanmugam G, Wang D, Gounder SS, Fernandes J, Litovsky SH, Whitehead K, Radhakrishnan RK, Franklin S, Hoidal J, Kensler TW, Dell'Italia L, Darley-Usmar V, Abel ED, Jones DP, Ping P, et al. Reductive Stress Causes Pathological Cardiac Remodeling and Diastolic Dysfunction. Antioxidants & Redox Signaling. PMID 32064894 DOI: 10.1089/Ars.2019.7808 |
0.325 |
|
| 2019 |
Yagishita Y, Fahey JW, Dinkova-Kostova AT, Kensler TW. Broccoli or Sulforaphane: Is It the Source or Dose That Matters? Molecules (Basel, Switzerland). 24. PMID 31590459 DOI: 10.3390/Molecules24193593 |
0.301 |
|
| 2019 |
Livingstone MC, Johnson NM, Roebuck BD, Kensler TW, Groopman JD. Serum miR-182 is a predictive biomarker for dichotomization of risk of hepatocellular carcinoma in rats. Molecular Carcinogenesis. PMID 31373075 DOI: 10.1002/Mc.23093 |
0.483 |
|
| 2019 |
Chen JG, Johnson J, Egner P, Ng D, Zhu J, Wang JB, Xue XF, Sun Y, Zhang YH, Lu LL, Chen YS, Wu Y, Zhu YR, Carmella S, Hecht S, ... ... Kensler T, et al. Dose-dependent detoxication of the airborne pollutant benzene in a randomized trial of broccoli sprout beverage in Qidong, China. The American Journal of Clinical Nutrition. PMID 31268126 DOI: 10.1093/Ajcn/Nqz122 |
0.512 |
|
| 2019 |
Chen J, Zhu J, Wang G, Groopman JD, Kensler TW. Qidong: a crucible for studies on liver cancer etiology and prevention. Cancer Biology & Medicine. 16: 24-37. PMID 31119044 DOI: 10.20892/J.Issn.2095-3941.2018.0394 |
0.541 |
|
| 2019 |
Fragoulis A, Schenkel J, Herzog M, Schellenberg T, Jahr H, Pufe T, Trautwein C, Kensler TW, Streetz KL, Wruck CJ. Nrf2 ameliorates DDC-induced sclerosing cholangitis and biliary fibrosis and improves the regenerative capacity of the liver. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 30825315 DOI: 10.1093/Toxsci/Kfz055 |
0.375 |
|
| 2019 |
Chartoumpekis DV, Ziros PG, Chen JG, Groopman JD, Kensler TW, Sykiotis GP. Broccoli sprout beverage is safe for thyroid hormonal and autoimmune status: Results of a 12-week randomized trial. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. PMID 30735751 DOI: 10.1016/J.Fct.2019.02.004 |
0.466 |
|
| 2018 |
Palliyaguru DL, Salvatore SR, Schopfer FJ, Cheng X, Zhou J, Kensler TW, Wendell SG. Evaluation of 2-thiothiazolidine-4-carboxylic Acid, a Common Metabolite of Isothiocyanates as a Potential Biomarker of Cruciferous Vegetable Intake. Molecular Nutrition & Food Research. e1801029. PMID 30408325 DOI: 10.1002/Mnfr.201801029 |
0.308 |
|
| 2018 |
Chen T, Qian G, Fan C, Sun Y, Wang J, Lu P, Xue X, Wu Y, Zhang Q, Jin Y, Wu Y, Gan Y, Lu J, Kensler TW, Groopman JD, et al. Qidong hepatitis B virus infection cohort: a 25-year prospective study in high risk area of primary liver cancer. Hepatoma Research. 4. PMID 29479565 DOI: 10.20517/2394-5079.2017.50 |
0.52 |
|
| 2018 |
Wible RS, Tran QT, Fathima S, Sutter CH, Kensler TW, Sutter TR. Pharmacogenomics of chemically distinct classes of Keap1-Nrf2 activators identify common and unique gene, protein, and pathway responses in vivo. Molecular Pharmacology. PMID 29367259 DOI: 10.1124/Mol.117.110262 |
0.314 |
|
| 2017 |
Livingstone MC, Johnson NM, Roebuck BD, Kensler TW, Groopman JD. Profound changes in miRNA expression during cancer initiation by aflatoxin B1 and their abrogation by the chemopreventive triterpenoid CDDO-Im. Molecular Carcinogenesis. PMID 28218475 DOI: 10.1002/Mc.22635 |
0.48 |
|
| 2016 |
Bauman JE, Zang Y, Sen M, Li C, Wang L, Egner PA, Fahey JW, Normolle DP, Grandis JR, Kensler TW, Johnson DE. Prevention of Carcinogen-Induced Oral Cancer by Sulforaphane. Cancer Prevention Research (Philadelphia, Pa.). PMID 27339168 DOI: 10.1158/1940-6207.Capr-15-0290 |
0.413 |
|
| 2016 |
Taguchi K, Takaku M, Egner PA, Morita M, Kaneko T, Mashimo T, Kensler TW, Yamamoto M. Generation of A New Model Rat: Nrf2 Knockout Rats Are Sensitive to Aflatoxin B1 Toxicity. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 27071940 DOI: 10.1093/Toxsci/Kfw065 |
0.366 |
|
| 2015 |
Slocum SL, Skoko JJ, Wakabayashi N, Aja S, Yamamoto M, Kensler TW, Chartoumpekis DV. Keap1/Nrf2 pathway activation leads to a repressed hepatic gluconeogenic and lipogenic program in mice on a high-fat diet. Archives of Biochemistry and Biophysics. PMID 26701603 DOI: 10.1016/J.Abb.2015.11.040 |
0.778 |
|
| 2015 |
Wakabayashi N, Chartoumpekis DV, Kensler TW. Crosstalk between Nrf2 and Notch signaling. Free Radical Biology & Medicine. 88: 158-67. PMID 26003520 DOI: 10.1016/J.Freeradbiomed.2015.05.017 |
0.392 |
|
| 2014 |
Wu F, Mitchell NJ, Male D, Kensler TW. Reduced foodborne toxin exposure is a benefit of improving dietary diversity. Toxicological Sciences : An Official Journal of the Society of Toxicology. 141: 329-34. PMID 25015663 DOI: 10.1093/Toxsci/Kfu137 |
0.315 |
|
| 2014 |
Skoko JJ, Wakabayashi N, Noda K, Kimura S, Tobita K, Shigemura N, Tsujita T, Yamamoto M, Kensler TW. Loss of Nrf2 in mice evokes a congenital intrahepatic shunt that alters hepatic oxygen and protein expression gradients and toxicity. Toxicological Sciences : An Official Journal of the Society of Toxicology. 141: 112-9. PMID 24924401 DOI: 10.1093/Toxsci/Kfu109 |
0.354 |
|
| 2014 |
Egner PA, Chen JG, Zarth AT, Ng DK, Wang JB, Kensler KH, Jacobson LP, Muñoz A, Johnson JL, Groopman JD, Fahey JW, Talalay P, Zhu J, Chen TY, Qian GS, ... ... Kensler TW, et al. Rapid and sustainable detoxication of airborne pollutants by broccoli sprout beverage: results of a randomized clinical trial in China. Cancer Prevention Research (Philadelphia, Pa.). 7: 813-23. PMID 24913818 DOI: 10.1158/1940-6207.Capr-14-0103 |
0.547 |
|
| 2014 |
Kensler KH, Slocum SL, Chartoumpekis DV, Dolan PM, Johnson NM, Ilic Z, Crawford DR, Sell S, Groopman JD, Kensler TW, Egner PA. Genetic or pharmacologic activation of Nrf2 signaling fails to protect against aflatoxin genotoxicity in hypersensitive GSTA3 knockout mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. 139: 293-300. PMID 24675090 DOI: 10.1093/Toxsci/Kfu056 |
0.795 |
|
| 2014 |
Johnson NM, Egner PA, Baxter VK, Sporn MB, Wible RS, Sutter TR, Groopman JD, Kensler TW, Roebuck BD. Complete protection against aflatoxin B(1)-induced liver cancer with a triterpenoid: DNA adduct dosimetry, molecular signature, and genotoxicity threshold. Cancer Prevention Research (Philadelphia, Pa.). 7: 658-65. PMID 24662598 DOI: 10.1158/1940-6207.Capr-13-0430 |
0.586 |
|
| 2014 |
Wakabayashi N, Skoko JJ, Chartoumpekis DV, Kimura S, Slocum SL, Noda K, Palliyaguru DL, Fujimuro M, Boley PA, Tanaka Y, Shigemura N, Biswal S, Yamamoto M, Kensler TW. Notch-Nrf2 axis: regulation of Nrf2 gene expression and cytoprotection by notch signaling. Molecular and Cellular Biology. 34: 653-63. PMID 24298019 DOI: 10.1128/Mcb.01408-13 |
0.783 |
|
| 2014 |
Chen JG, Kensler TW. Changing rates for liver and lung cancers in Qidong, China. Chemical Research in Toxicology. 27: 3-6. PMID 24215631 DOI: 10.1021/Tx400313J |
0.31 |
|
| 2013 |
Chen JG, Egner PA, Ng D, Jacobson LP, Muñoz A, Zhu YR, Qian GS, Wu F, Yuan JM, Groopman JD, Kensler TW. Reduced aflatoxin exposure presages decline in liver cancer mortality in an endemic region of China. Cancer Prevention Research (Philadelphia, Pa.). 6: 1038-45. PMID 23963804 DOI: 10.1158/1940-6207.Capr-13-0168 |
0.469 |
|
| 2013 |
Vitturi DA, Chen CS, Woodcock SR, Salvatore SR, Bonacci G, Koenitzer JR, Stewart NA, Wakabayashi N, Kensler TW, Freeman BA, Schopfer FJ. Modulation of nitro-fatty acid signaling: prostaglandin reductase-1 is a nitroalkene reductase. The Journal of Biological Chemistry. 288: 25626-37. PMID 23878198 DOI: 10.1074/Jbc.M113.486282 |
0.353 |
|
| 2013 |
Yang L, Zahid M, Liao Y, Rogan EG, Cavalieri EL, Davidson NE, Yager JD, Visvanathan K, Groopman JD, Kensler TW. Reduced formation of depurinating estrogen-DNA adducts by sulforaphane or KEAP1 disruption in human mammary epithelial MCF-10A cells. Carcinogenesis. 34: 2587-92. PMID 23843041 DOI: 10.1093/Carcin/Bgt246 |
0.556 |
|
| 2013 |
Kannan S, Muthusamy VR, Whitehead KJ, Wang L, Gomes AV, Litwin SE, Kensler TW, Abel ED, Hoidal JR, Rajasekaran NS. Nrf2 deficiency prevents reductive stress-induced hypertrophic cardiomyopathy. Cardiovascular Research. 100: 63-73. PMID 23761402 DOI: 10.1016/J.Freeradbiomed.2013.10.593 |
0.315 |
|
| 2013 |
Uruno A, Furusawa Y, Yagishita Y, Fukutomi T, Muramatsu H, Negishi T, Sugawara A, Kensler TW, Yamamoto M. The Keap1-Nrf2 system prevents onset of diabetes mellitus. Molecular and Cellular Biology. 33: 2996-3010. PMID 23716596 DOI: 10.1128/Mcb.00225-13 |
0.313 |
|
| 2013 |
Kensler TW, Egner PA, Agyeman AS, Visvanathan K, Groopman JD, Chen JG, Chen TY, Fahey JW, Talalay P. Keap1-nrf2 signaling: a target for cancer prevention by sulforaphane. Topics in Current Chemistry. 329: 163-77. PMID 22752583 DOI: 10.1007/128_2012_339 |
0.803 |
|
| 2013 |
Egner PA, Chen J, Ng D, Jacobson LP, Munoz A, Lu J, Zhu Y, Qian G, Chen T, Wu F, Wang J, Groopman JD, Kensler TW. Abstract 1381: Reduction in aflatoxin exposure drives decrease in primary liver cancer in Qidong, China. Cancer Research. 73: 1381-1381. DOI: 10.1158/1538-7445.Am2013-1381 |
0.538 |
|
| 2012 |
Weerachayaphorn J, Mennone A, Soroka CJ, Harry K, Hagey LR, Kensler TW, Boyer JL. Nuclear factor-E2-related factor 2 is a major determinant of bile acid homeostasis in the liver and intestine. American Journal of Physiology. Gastrointestinal and Liver Physiology. 302: G925-36. PMID 22345550 DOI: 10.1152/Ajpgi.00263.2011 |
0.326 |
|
| 2012 |
Fahey JW, Wehage SL, Holtzclaw WD, Kensler TW, Egner PA, Shapiro TA, Talalay P. Protection of humans by plant glucosinolates: Efficiency of conversion of glucosinolates to isothiocyanates by the gastrointestinal microflora Cancer Prevention Research. 5: 603-611. PMID 22318753 DOI: 10.1158/1940-6207.Capr-11-0538 |
0.32 |
|
| 2012 |
Kensler TW, Ng D, Carmella SG, Chen M, Jacobson LP, Muñoz A, Egner PA, Chen JG, Qian GS, Chen TY, Fahey JW, Talalay P, Groopman JD, Yuan JM, Hecht SS. Modulation of the metabolism of airborne pollutants by glucoraphanin-rich and sulforaphane-rich broccoli sprout beverages in Qidong, China. Carcinogenesis. 33: 101-7. PMID 22045030 DOI: 10.1093/Carcin/Bgr229 |
0.552 |
|
| 2012 |
Wogan GN, Kensler TW, Groopman JD. Present and future directions of translational research on aflatoxin and hepatocellular carcinoma. A review. Food Additives & Contaminants. Part a, Chemistry, Analysis, Control, Exposure & Risk Assessment. 29: 249-57. PMID 21623489 DOI: 10.1080/19440049.2011.563370 |
0.646 |
|
| 2012 |
Agyeman AS, Chaerkady R, Shaw PG, Davidson NE, Visvanathan K, Pandey A, Kensler TW. Transcriptomic and proteomic profiling of KEAP1 disrupted and sulforaphane-treated human breast epithelial cells reveals common expression profiles. Breast Cancer Research and Treatment. 132: 175-87. PMID 21597922 DOI: 10.1007/S10549-011-1536-9 |
0.79 |
|
| 2012 |
Kensler TW. Abstract CN05-01: Viral and Dietary Factors in Declining Liver Cancer Mortality in Qidong, China Cancer Prevention Research. 5: CN05-01-CN05-01. DOI: 10.1158/1940-6207.Prev-12-Cn05-01 |
0.328 |
|
| 2012 |
Kensler TW, Groopman JD, Egner PA, Muñoz A, Qian G, Chen J. Chemoprevention of hepatic cancer in aflatoxin endemic areas Primary Liver Cancer: Challenges and Perspectives. 2147483647: 339-365. DOI: 10.1007/978-3-642-28702-2_11 |
0.507 |
|
| 2011 |
Muñoz A, Chen JG, Egner PA, Marshall ML, Johnson JL, Schneider MF, Lu JH, Zhu YR, Wang JB, Chen TY, Kensler TW, Groopman JD. Predictive power of hepatitis B 1762T/1764A mutations in plasma for hepatocellular carcinoma risk in Qidong, China. Carcinogenesis. 32: 860-5. PMID 21474708 DOI: 10.1093/Carcin/Bgr055 |
0.491 |
|
| 2011 |
Egner PA, Chen JG, Wang JB, Wu Y, Sun Y, Lu JH, Zhu J, Zhang YH, Chen YS, Friesen MD, Jacobson LP, Muñoz A, Ng D, Qian GS, Zhu YR, ... ... Kensler TW, et al. Bioavailability of Sulforaphane from two broccoli sprout beverages: results of a short-term, cross-over clinical trial in Qidong, China. Cancer Prevention Research (Philadelphia, Pa.). 4: 384-95. PMID 21372038 DOI: 10.1158/1940-6207.Capr-10-0296 |
0.522 |
|
| 2011 |
Slocum SL, Kensler TW. Nrf2: control of sensitivity to carcinogens. Archives of Toxicology. 85: 273-84. PMID 21369766 DOI: 10.1007/S00204-011-0675-4 |
0.79 |
|
| 2011 |
You A, Nam CW, Wakabayashi N, Yamamoto M, Kensler TW, Kwak MK. Transcription factor Nrf2 maintains the basal expression of Mdm2: An implication of the regulation of p53 signaling by Nrf2. Archives of Biochemistry and Biophysics. 507: 356-64. PMID 21211512 DOI: 10.1016/J.Abb.2010.12.034 |
0.389 |
|
| 2011 |
Kensler TW, Roebuck BD, Wogan GN, Groopman JD. Aflatoxin: a 50-year odyssey of mechanistic and translational toxicology. Toxicological Sciences : An Official Journal of the Society of Toxicology. 120: S28-48. PMID 20881231 DOI: 10.1093/Toxsci/Kfq283 |
0.662 |
|
| 2011 |
Egner PA, Chen JG, Wang JB, Friesen MD, Jacobson LP, Munoz A, Ng D, Chen TY, Fahey JW, Talalay P, Carmella SG, Hecht SS, Groopman JD, Kensler TW. Abstract LB-405: Modulation of the metabolism of air-borne pollutants by broccoli sprout beverages: Results of a short term, cross-over clinical trial in Qidong, People's Republic of China Cancer Research. 71. DOI: 10.1158/1538-7445.Am2011-Lb-405 |
0.562 |
|
| 2010 |
Wakabayashi N, Shin S, Slocum SL, Agoston ES, Wakabayashi J, Kwak MK, Misra V, Biswal S, Yamamoto M, Kensler TW. Regulation of notch1 signaling by nrf2: implications for tissue regeneration. Science Signaling. 3: ra52. PMID 20628156 DOI: 10.1126/Scisignal.2000762 |
0.782 |
|
| 2010 |
Malhotra D, Portales-Casamar E, Singh A, Srivastava S, Arenillas D, Happel C, Shyr C, Wakabayashi N, Kensler TW, Wasserman WW, Biswal S. Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis. Nucleic Acids Research. 38: 5718-34. PMID 20460467 DOI: 10.1093/Nar/Gkq212 |
0.382 |
|
| 2010 |
Shah ZA, Li RC, Ahmad AS, Kensler TW, Yamamoto M, Biswal S, Doré S. The flavanol (-)-epicatechin prevents stroke damage through the Nrf2/HO1 pathway. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 30: 1951-61. PMID 20442725 DOI: 10.1038/Jcbfm.2010.53 |
0.322 |
|
| 2010 |
Wakabayashi N, Slocum SL, Skoko JJ, Shin S, Kensler TW. When NRF2 talks, who's listening? Antioxidants & Redox Signaling. 13: 1649-63. PMID 20367496 DOI: 10.1089/Ars.2010.3216 |
0.799 |
|
| 2010 |
Shin DH, Park HM, Jung KA, Choi HG, Kim JA, Kim DD, Kim SG, Kang KW, Ku SK, Kensler TW, Kwak MK. The NRF2-heme oxygenase-1 system modulates cyclosporin A-induced epithelial-mesenchymal transition and renal fibrosis. Free Radical Biology & Medicine. 48: 1051-63. PMID 20096777 DOI: 10.1016/J.Freeradbiomed.2010.01.021 |
0.34 |
|
| 2010 |
Zhou Q, Chaerkady R, Shaw PG, Kensler TW, Pandey A, Davidson NE. Screening for therapeutic targets of vorinostat by SILAC-based proteomic analysis in human breast cancer cells. Proteomics. 10: 1029-39. PMID 20049865 DOI: 10.1002/Pmic.200900602 |
0.326 |
|
| 2010 |
Kensler TW, Wakabayashi N. Nrf2: friend or foe for chemoprevention? Carcinogenesis. 31: 90-9. PMID 19793802 DOI: 10.1093/Carcin/Bgp231 |
0.384 |
|
| 2010 |
Kwak MK, Kensler TW. Targeting NRF2 signaling for cancer chemoprevention. Toxicology and Applied Pharmacology. 244: 66-76. PMID 19732782 DOI: 10.1016/J.Taap.2009.08.028 |
0.434 |
|
| 2010 |
Gruber F, Mayer H, Lengauer B, Mlitz V, Sanders JM, Kadl A, Bilban M, de Martin R, Wagner O, Kensler TW, Yamamoto M, Leitinger N, Tschachler E. NF-E2-related factor 2 regulates the stress response to UVA-1-oxidized phospholipids in skin cells. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 39-48. PMID 19720622 DOI: 10.1096/Fj.09-133520 |
0.354 |
|
| 2010 |
Agyeman A, Chaerkady R, Shaw P, Jacob HKC, Visvanathan K, Pandey A, Davidson N, Kensler T. Abstract A47: Establishing candidate biomarkers for the pharmacodynamic action of sulforaphane in the breast Cancer Prevention Research. 3. DOI: 10.1158/1940-6207.Prev-10-A47 |
0.803 |
|
| 2010 |
Agyeman A, Shaw P, Chaerkady R, Tran Q, Sutter T, Pandey A, Visvanathan K, Davidson N, Kensler T. Abstract 5700: Establishing candidate biomarkers for the pharmacodynamic action of sulforaphane in the breast Cancer Research. 70: 5700-5700. DOI: 10.1158/1538-7445.Am10-5700 |
0.801 |
|
| 2010 |
Groopman JD, Kensler TW. Food safety | Mycotoxins Encyclopedia of Human Nutrition. 317-323. DOI: 10.1016/B0-12-226694-3/00134-4 |
0.375 |
|
| 2009 |
Kensler TW, Groopman JD. Is it time to advance the chemoprevention of environmental carcinogenesis with microdosing trials? Cancer Prevention Research (Philadelphia, Pa.). 2: 1003-7. PMID 19952364 DOI: 10.1158/1940-6207.Capr-09-0232 |
0.492 |
|
| 2009 |
Holland R, Navamal M, Velayutham M, Zweier JL, Kensler TW, Fishbein JC. Hydrogen peroxide is a second messenger in phase 2 enzyme induction by cancer chemopreventive dithiolethiones. Chemical Research in Toxicology. 22: 1427-34. PMID 19785463 DOI: 10.1021/Tx900110N |
0.314 |
|
| 2009 |
Wakabayashi J, Zhang Z, Wakabayashi N, Tamura Y, Fukaya M, Kensler TW, Iijima M, Sesaki H. The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice. The Journal of Cell Biology. 186: 805-16. PMID 19752021 DOI: 10.1083/Jcb.200903065 |
0.304 |
|
| 2009 |
Reddy NM, Suryanarayana V, Kalvakolanu DV, Yamamoto M, Kensler TW, Hassoun PM, Kleeberger SR, Reddy SP. Innate immunity against bacterial infection following hyperoxia exposure is impaired in NRF2-deficient mice. Journal of Immunology (Baltimore, Md. : 1950). 183: 4601-8. PMID 19734219 DOI: 10.4049/Jimmunol.0901754 |
0.356 |
|
| 2009 |
Shin S, Wakabayashi J, Yates MS, Wakabayashi N, Dolan PM, Aja S, Liby KT, Sporn MB, Yamamoto M, Kensler TW. Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-imidazolide. European Journal of Pharmacology. 620: 138-44. PMID 19698707 DOI: 10.1016/J.Ejphar.2009.08.022 |
0.79 |
|
| 2009 |
Reddy NM, Suryanaraya V, Yates MS, Kleeberger SR, Hassoun PM, Yamamoto M, Liby KT, Sporn MB, Kensler TW, Reddy SP. The triterpenoid CDDO-imidazolide confers potent protection against hyperoxic acute lung injury in mice. American Journal of Respiratory and Critical Care Medicine. 180: 867-74. PMID 19679692 DOI: 10.1164/Rccm.200905-0670Oc |
0.654 |
|
| 2009 |
Reddy NM, Kleeberger SR, Kensler TW, Yamamoto M, Hassoun PM, Reddy SP. Disruption of Nrf2 impairs the resolution of hyperoxia-induced acute lung injury and inflammation in mice. Journal of Immunology (Baltimore, Md. : 1950). 182: 7264-71. PMID 19454723 DOI: 10.4049/Jimmunol.0804248 |
0.351 |
|
| 2009 |
Nagai N, Thimmulappa RK, Cano M, Fujihara M, Izumi-Nagai K, Kong X, Sporn MB, Kensler TW, Biswal S, Handa JT. Nrf2 is a critical modulator of the innate immune response in a model of uveitis. Free Radical Biology & Medicine. 47: 300-6. PMID 19410644 DOI: 10.1016/J.Freeradbiomed.2009.04.033 |
0.338 |
|
| 2009 |
Yates MS, Tran QT, Dolan PM, Osburn WO, Shin S, McCulloch CC, Silkworth JB, Taguchi K, Yamamoto M, Williams CR, Liby KT, Sporn MB, Sutter TR, Kensler TW. Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice. Carcinogenesis. 30: 1024-31. PMID 19386581 DOI: 10.1093/Carcin/Bgp100 |
0.802 |
|
| 2009 |
Roebuck BD, Johnson DN, Sutter CH, Egner PA, Scholl PF, Friesen MD, Baumgartner KJ, Ware NM, Bodreddigari S, Groopman JD, Kensler TW, Sutter TR. Transgenic expression of aflatoxin aldehyde reductase (AKR7A1) modulates aflatoxin B1 metabolism but not hepatic carcinogenesis in the rat. Toxicological Sciences : An Official Journal of the Society of Toxicology. 109: 41-9. PMID 19168568 DOI: 10.1093/Toxsci/Kfp003 |
0.572 |
|
| 2009 |
Tran QT, Xu L, Phan V, Goodwin SB, Rahman M, Jin VX, Sutter CH, Roebuck BD, Kensler TW, George EO, Sutter TR. Chemical genomics of cancer chemopreventive dithiolethiones. Carcinogenesis. 30: 480-6. PMID 19126641 DOI: 10.1093/Carcin/Bgn292 |
0.39 |
|
| 2009 |
Sussan TE, Rangasamy T, Blake DJ, Malhotra D, El-Haddad H, Bedja D, Yates MS, Kombairaju P, Yamamoto M, Liby KT, Sporn MB, Gabrielson KL, Champion HC, Tuder RM, Kensler TW, et al. Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice. Proceedings of the National Academy of Sciences of the United States of America. 106: 250-5. PMID 19104057 DOI: 10.1073/Pnas.0804333106 |
0.686 |
|
| 2009 |
Singh A, Ling G, Suhasini AN, Zhang P, Yamamoto M, Navas-Acien A, Cosgrove G, Tuder RM, Kensler TW, Watson WH, Biswal S. Nrf2-dependent sulfiredoxin-1 expression protects against cigarette smoke-induced oxidative stress in lungs. Free Radical Biology & Medicine. 46: 376-86. PMID 19027064 DOI: 10.1016/J.Freeradbiomed.2008.10.026 |
0.347 |
|
| 2008 |
Colburn NH, Kensler TW. Targeting transcription factors for cancer prevention--the case of Nrf2. Cancer Prevention Research (Philadelphia, Pa.). 1: 153-5. PMID 19138949 DOI: 10.1158/1940-6207.Capr-08-0025 |
0.341 |
|
| 2008 |
Williams MA, Rangasamy T, Bauer SM, Killedar S, Karp M, Kensler TW, Yamamoto M, Breysse P, Biswal S, Georas SN. Disruption of the transcription factor Nrf2 promotes pro-oxidative dendritic cells that stimulate Th2-like immunoresponsiveness upon activation by ambient particulate matter. Journal of Immunology (Baltimore, Md. : 1950). 181: 4545-59. PMID 18802057 DOI: 10.4049/Jimmunol.181.7.4545 |
0.331 |
|
| 2008 |
Egner PA, Kensler TW, Chen JG, Gange SJ, Groopman JD, Friesen MD. Quantification of sulforaphane mercapturic acid pathway conjugates in human urine by high-performance liquid chromatography and isotope-dilution tandem mass spectrometry. Chemical Research in Toxicology. 21: 1991-6. PMID 18729326 DOI: 10.1021/Tx800210K |
0.54 |
|
| 2008 |
Liby K, Yore MM, Roebuck BD, Baumgartner KJ, Honda T, Sundararajan C, Yoshizawa H, Gribble GW, Williams CR, Risingsong R, Royce DB, Dinkova-Kostova AT, Stephenson KK, Egner PA, Yates MS, ... ... Kensler TW, et al. A novel acetylenic tricyclic bis-(cyano enone) potently induces phase 2 cytoprotective pathways and blocks liver carcinogenesis induced by aflatoxin Cancer Research. 68: 6727-6733. PMID 18701497 DOI: 10.1158/0008-5472.Can-08-1123 |
0.747 |
|
| 2008 |
Bransfield LA, Rennie A, Visvanathan K, Odwin SA, Kensler TW, Yager JD, Friesen MD, Groopman JD. Formation of two novel estrogen guanine adducts and HPLC/MS detection of 4-hydroxyestradiol-N7-guanine in human urine. Chemical Research in Toxicology. 21: 1622-30. PMID 18582124 DOI: 10.1021/Tx800145W |
0.529 |
|
| 2008 |
Reddy NM, Kleeberger SR, Bream JH, Fallon PG, Kensler TW, Yamamoto M, Reddy SP. Genetic disruption of the Nrf2 compromises cell-cycle progression by impairing GSH-induced redox signaling. Oncogene. 27: 5821-32. PMID 18542053 DOI: 10.1038/Onc.2008.188 |
0.372 |
|
| 2008 |
Osburn WO, Yates MS, Dolan PD, Chen S, Liby KT, Sporn MB, Taguchi K, Yamamoto M, Kensler TW. Genetic or pharmacologic amplification of nrf2 signaling inhibits acute inflammatory liver injury in mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. 104: 218-27. PMID 18417483 DOI: 10.1093/Toxsci/Kfn079 |
0.805 |
|
| 2008 |
Bodreddigari S, Jones LK, Egner PA, Groopman JD, Sutter CH, Roebuck BD, Guengerich FP, Kensler TW, Sutter TR. Protection against aflatoxin B1-induced cytotoxicity by expression of the cloned aflatoxin B1-aldehyde reductases rat AKR7A1 and human AKR7A3. Chemical Research in Toxicology. 21: 1134-42. PMID 18416522 DOI: 10.1021/Tx7004458 |
0.548 |
|
| 2008 |
Pearson KJ, Lewis KN, Price NL, Chang JW, Perez E, Cascajo MV, Tamashiro KL, Poosala S, Csiszar A, Ungvari Z, Kensler TW, Yamamoto M, Egan JM, Longo DL, Ingram DK, et al. Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction. Proceedings of the National Academy of Sciences of the United States of America. 105: 2325-30. PMID 18287083 DOI: 10.1073/Pnas.0712162105 |
0.342 |
|
| 2008 |
Johnson DN, Egner PA, Obrian G, Glassbrook N, Roebuck BD, Sutter TR, Payne GA, Kensler TW, Groopman JD. Quantification of urinary aflatoxin B1 dialdehyde metabolites formed by aflatoxin aldehyde reductase using isotope dilution tandem mass spectrometry. Chemical Research in Toxicology. 21: 752-60. PMID 18266327 DOI: 10.1021/Tx700397N |
0.52 |
|
| 2008 |
Osburn WO, Kensler TW. Nrf2 signaling: an adaptive response pathway for protection against environmental toxic insults. Mutation Research. 659: 31-9. PMID 18164232 DOI: 10.1016/J.Mrrev.2007.11.006 |
0.739 |
|
| 2008 |
Groopman JD, Kensler TW, Wild CP. Protective interventions to prevent aflatoxin-induced carcinogenesis in developing countries. Annual Review of Public Health. 29: 187-203. PMID 17914931 DOI: 10.1146/Annurev.Publhealth.29.020907.090859 |
0.528 |
|
| 2008 |
Zhou Q, Chaerkady R, Shaw P, Kensler T, Pandey A, Davidson N. Abstract B104: Targeting Nrf2/ARE pathway by inhibition of HDAC in breast cancer prevention Cancer Prevention Research. 1. DOI: 10.1158/1940-6207.Prev-08-B104 |
0.387 |
|
| 2008 |
Groopman JD, Kensler TW, Wild C. Aflatoxin, Hepatitis B Virus and Liver Cancer: A Paradigm for Molecular Epidemiology Molecular Epidemiology of Chronic Diseases. 323-342. DOI: 10.1002/9780470725726.ch25 |
0.462 |
|
| 2007 |
Reddy NM, Kleeberger SR, Yamamoto M, Kensler TW, Scollick C, Biswal S, Reddy SP. Genetic dissection of the Nrf2-dependent redox signaling-regulated transcriptional programs of cell proliferation and cytoprotection. Physiological Genomics. 32: 74-81. PMID 17895394 DOI: 10.1152/Physiolgenomics.00126.2007 |
0.384 |
|
| 2007 |
Manandhar S, Cho JM, Kim JA, Kensler TW, Kwak MK. Induction of Nrf2-regulated genes by 3H-1, 2-dithiole-3-thione through the ERK signaling pathway in murine keratinocytes. European Journal of Pharmacology. 577: 17-27. PMID 17854798 DOI: 10.1016/J.Ejphar.2007.08.018 |
0.383 |
|
| 2007 |
Thimmulappa RK, Fuchs RJ, Malhotra D, Scollick C, Traore K, Bream JH, Trush MA, Liby KT, Sporn MB, Kensler TW, Biswal S. Preclinical evaluation of targeting the Nrf2 pathway by triterpenoids (CDDO-Im and CDDO-Me) for protection from LPS-induced inflammatory response and reactive oxygen species in human peripheral blood mononuclear cells and neutrophils. Antioxidants & Redox Signaling. 9: 1963-70. PMID 17822364 DOI: 10.1089/Ars.2007.1745 |
0.357 |
|
| 2007 |
Yates MS, Kensler TW. Keap1 eye on the target: chemoprevention of liver cancer. Acta Pharmacologica Sinica. 28: 1331-42. PMID 17723167 DOI: 10.1111/J.1745-7254.2007.00688.X |
0.694 |
|
| 2007 |
Shin S, Wakabayashi N, Misra V, Biswal S, Lee GH, Agoston ES, Yamamoto M, Kensler TW. NRF2 modulates aryl hydrocarbon receptor signaling: influence on adipogenesis. Molecular and Cellular Biology. 27: 7188-97. PMID 17709388 DOI: 10.1128/Mcb.00915-07 |
0.791 |
|
| 2007 |
Kwak MK, Cho JM, Huang B, Shin S, Kensler TW. Role of increased expression of the proteasome in the protective effects of sulforaphane against hydrogen peroxide-mediated cytotoxicity in murine neuroblastoma cells. Free Radical Biology & Medicine. 43: 809-17. PMID 17664144 DOI: 10.1016/J.Freeradbiomed.2007.05.029 |
0.74 |
|
| 2007 |
Osburn WO, Karim B, Dolan PM, Liu G, Yamamoto M, Huso DL, Kensler TW. Increased colonic inflammatory injury and formation of aberrant crypt foci in Nrf2-deficient mice upon dextran sulfate treatment. International Journal of Cancer. 121: 1883-91. PMID 17631644 DOI: 10.1002/Ijc.22943 |
0.791 |
|
| 2007 |
Wang J, Fields J, Zhao C, Langer J, Thimmulappa RK, Kensler TW, Yamamoto M, Biswal S, Doré S. Role of Nrf2 in protection against intracerebral hemorrhage injury in mice. Free Radical Biology & Medicine. 43: 408-14. PMID 17602956 DOI: 10.1016/J.Freeradbiomed.2007.04.020 |
0.32 |
|
| 2007 |
Chen JG, Kuang SY, Egner PA, Lu JH, Zhu YR, Wang JB, Zhang BC, Chen TY, Muñoz A, Kensler TW, Groopman JD. Acceleration to death from liver cancer in people with hepatitis B viral mutations detected in plasma by mass spectrometry. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 16: 1213-8. PMID 17548687 DOI: 10.1158/1055-9965.Epi-06-0905 |
0.507 |
|
| 2007 |
Kwak MK, Huang B, Chang H, Kim JA, Kensler TW. Tissue specific increase of the catalytic subunits of the 26S proteasome by indirect antioxidant dithiolethione in mice: enhanced activity for degradation of abnormal protein. Life Sciences. 80: 2411-20. PMID 17521679 DOI: 10.1016/J.Lfs.2007.04.014 |
0.362 |
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| 2007 |
Shah ZA, Li RC, Thimmulappa RK, Kensler TW, Yamamoto M, Biswal S, Doré S. Role of reactive oxygen species in modulation of Nrf2 following ischemic reperfusion injury. Neuroscience. 147: 53-9. PMID 17507167 DOI: 10.1016/J.Neuroscience.2007.02.066 |
0.309 |
|
| 2007 |
Yates MS, Kensler TW. Chemopreventive promise of targeting the Nrf2 pathway. Drug News & Perspectives. 20: 109-17. PMID 17440634 DOI: 10.1358/Dnp.2007.20.2.1083437 |
0.701 |
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| 2007 |
Reddy NM, Kleeberger SR, Cho HY, Yamamoto M, Kensler TW, Biswal S, Reddy SP. Deficiency in Nrf2-GSH signaling impairs type II cell growth and enhances sensitivity to oxidants. American Journal of Respiratory Cell and Molecular Biology. 37: 3-8. PMID 17413030 DOI: 10.1165/Rcmb.2007-0004Rc |
0.363 |
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| 2007 |
Cornblatt BS, Ye L, Dinkova-Kostova AT, Erb M, Fahey JW, Singh NK, Chen MSA, Stierer T, Garrett-Mayer E, Argani P, Davidson NE, Talalay P, Kensler TW, Visvanathan K. Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast Carcinogenesis. 28: 1485-1490. PMID 17347138 DOI: 10.1093/Carcin/Bgm049 |
0.364 |
|
| 2007 |
Simonich MT, Egner PA, Roebuck BD, Orner GA, Jubert C, Pereira C, Groopman JD, Kensler TW, Dashwood RH, Williams DE, Bailey GS. Natural chlorophyll inhibits aflatoxin B1-induced multi-organ carcinogenesis in the rat. Carcinogenesis. 28: 1294-302. PMID 17290047 DOI: 10.1093/Carcin/Bgm027 |
0.536 |
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| 2007 |
Yates MS, Tauchi M, Katsuoka F, Flanders KC, Liby KT, Honda T, Gribble GW, Johnson DA, Johnson JA, Burton NC, Guilarte TR, Yamamoto M, Sporn MB, Kensler TW. Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes. Molecular Cancer Therapeutics. 6: 154-62. PMID 17237276 DOI: 10.1158/1535-7163.Mct-06-0516 |
0.673 |
|
| 2007 |
Posner GH, Suh BC, Petersen KS, Dolan P, Agoston ES, Kensler TW, Koh JT, Peleg S. Difluoromethyl analogs of the natural hormone 1α,25-dihydroxyvitamin D3: Design, synthesis, and preliminary biological evaluation Journal of Steroid Biochemistry and Molecular Biology. 103: 213-221. PMID 17218093 DOI: 10.1016/J.Jsbmb.2006.12.024 |
0.764 |
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| 2007 |
Pratt MM, Reddy AP, Hendricks JD, Pereira C, Kensler TW, Bailey GS. The importance of carcinogen dose in chemoprevention studies: quantitative interrelationships between, dibenzo[a,l]pyrene dose, chlorophyllin dose, target organ DNA adduct biomarkers and final tumor outcome. Carcinogenesis. 28: 611-24. PMID 16973675 DOI: 10.1093/Carcin/Bgl174 |
0.306 |
|
| 2007 |
Kensler TW, Wakabayashi N, Biswal S. Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annual Review of Pharmacology and Toxicology. 47: 89-116. PMID 16968214 DOI: 10.1146/Annurev.Pharmtox.46.120604.141046 |
0.392 |
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| 2007 |
Kwak M, Kensler TW. Cytoprotection Against Oxidative Damage by Nrf2-regulated Genes Toxicological Research. 23: 207-214. DOI: 10.5487/Tr.2007.23.3.207 |
0.414 |
|
| 2006 |
Peleg S, Petersen KS, Suh BC, Dolan P, Agoston ES, Kensler TW, Posner GH. Low-calcemic, highly antiproliferative, 1-difluoromethyl hybrid analogs of the natural hormone 1α,25-dihydroxyvitamin D3: Design, synthesis, and preliminary biological evaluation Journal of Medicinal Chemistry. 49: 7513-7517. PMID 17149880 DOI: 10.1021/Jm0609925 |
0.757 |
|
| 2006 |
Thimmulappa RK, Scollick C, Traore K, Yates M, Trush MA, Liby KT, Sporn MB, Yamamoto M, Kensler TW, Biswal S. Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide. Biochemical and Biophysical Research Communications. 351: 883-9. PMID 17097057 DOI: 10.1016/J.Bbrc.2006.10.102 |
0.664 |
|
| 2006 |
Egner PA, Groopman JD, Wang JS, Kensler TW, Friesen MD. Quantification of aflatoxin-B1-N7-Guanine in human urine by high-performance liquid chromatography and isotope dilution tandem mass spectrometry. Chemical Research in Toxicology. 19: 1191-5. PMID 16978023 DOI: 10.1021/Tx060108D |
0.528 |
|
| 2006 |
Osburn WO, Wakabayashi N, Misra V, Nilles T, Biswal S, Trush MA, Kensler TW. Nrf2 regulates an adaptive response protecting against oxidative damage following diquat-mediated formation of superoxide anion. Archives of Biochemistry and Biophysics. 454: 7-15. PMID 16962985 DOI: 10.1016/J.Abb.2006.08.005 |
0.719 |
|
| 2006 |
Burton NC, Kensler TW, Guilarte TR. In vivo modulation of the Parkinsonian phenotype by Nrf2. Neurotoxicology. 27: 1094-100. PMID 16959318 DOI: 10.1016/J.Neuro.2006.07.019 |
0.363 |
|
| 2006 |
Skipper PL, Trudel LJ, Kensler TW, Groopman JD, Egner PA, Liberman RG, Wogan GN, Tannenbaum SR. DNA adduct formation by 2,6-dimethyl-, 3,5-dimethyl-, and 3-ethylaniline in vivo in mice. Chemical Research in Toxicology. 19: 1086-90. PMID 16918249 DOI: 10.1021/Tx060082Q |
0.663 |
|
| 2006 |
Yu X, Egner PA, Wakabayashi J, Wakabayashi N, Yamamoto M, Kensler TW. Nrf2-mediated induction of cytoprotective enzymes by 15-deoxy-Delta12,14-prostaglandin J2 is attenuated by alkenal/one oxidoreductase. The Journal of Biological Chemistry. 281: 26245-52. PMID 16857669 DOI: 10.1074/Jbc.M604620200 |
0.359 |
|
| 2006 |
Singh A, Rangasamy T, Thimmulappa RK, Lee H, Osburn WO, Brigelius-Flohé R, Kensler TW, Yamamoto M, Biswal S. Glutathione peroxidase 2, the major cigarette smoke-inducible isoform of GPX in lungs, is regulated by Nrf2. American Journal of Respiratory Cell and Molecular Biology. 35: 639-50. PMID 16794261 DOI: 10.1165/Rcmb.2005-0325Oc |
0.709 |
|
| 2006 |
Kwak MK, Kensler TW. Induction of 26S proteasome subunit PSMB5 by the bifunctional inducer 3-methylcholanthrene through the Nrf2-ARE, but not the AhR/Arnt-XRE, pathway. Biochemical and Biophysical Research Communications. 345: 1350-7. PMID 16723119 DOI: 10.1016/J.Bbrc.2006.05.043 |
0.404 |
|
| 2006 |
Gong J, Neels JF, Yu X, Kensler TW, Peterson LA, Sturla SJ. Investigating the role of stereochemistry in the activity of anticancer acylfulvenes: synthesis, reductase-mediated bioactivation, and cellular toxicity. Journal of Medicinal Chemistry. 49: 2593-9. PMID 16610802 DOI: 10.1021/Jm051104T |
0.354 |
|
| 2006 |
Thimmulappa RK, Lee H, Rangasamy T, Reddy SP, Yamamoto M, Kensler TW, Biswal S. Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis. The Journal of Clinical Investigation. 116: 984-95. PMID 16585964 DOI: 10.1172/Jci25790 |
0.335 |
|
| 2006 |
Yates MS, Kwak MK, Egner PA, Groopman JD, Bodreddigari S, Sutter TR, Baumgartner KJ, Roebuck BD, Liby KT, Yore MM, Honda T, Gribble GW, Sporn MB, Kensler TW. Potent protection against aflatoxin-induced tumorigenesis through induction of Nrf2-regulated pathways by the triterpenoid 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole. Cancer Research. 66: 2488-94. PMID 16489057 DOI: 10.1158/0008-5472.Can-05-3823 |
0.752 |
|
| 2006 |
Agoston ES, Hatcher MA, Kensler TW, Posner GH. Vitamin D analogs as anti-carcinogenic agents Anti-Cancer Agents in Medicinal Chemistry. 6: 53-71. PMID 16475927 DOI: 10.2174/187152006784111369 |
0.773 |
|
| 2006 |
Scholl PF, McCoy L, Kensler TW, Groopman JD. Quantitative analysis and chronic dosimetry of the aflatoxin B1 plasma albumin adduct Lys-AFB1 in rats by isotope dilution mass spectrometry. Chemical Research in Toxicology. 19: 44-9. PMID 16411655 DOI: 10.1021/Tx050251R |
0.547 |
|
| 2006 |
Karuri AR, Huang Y, Bodreddigari S, Sutter CH, Roebuck BD, Kensler TW, Sutter TR. 3H-1,2-dithiole-3-thione targets nuclear factor kappaB to block expression of inducible nitric-oxide synthase, prevents hypotension, and improves survival in endotoxemic rats. The Journal of Pharmacology and Experimental Therapeutics. 317: 61-7. PMID 16371450 DOI: 10.1124/Jpet.105.096396 |
0.355 |
|
| 2006 |
Huang Y, Yan J, Lubet R, Kensler TW, Sutter TR. Identification of novel transcriptional networks in response to treatment with the anticarcinogen 3H-1,2-dithiole-3-thione. Physiological Genomics. 24: 144-53. PMID 16317079 DOI: 10.1152/Physiolgenomics.00258.2005 |
0.363 |
|
| 2006 |
Okawa H, Motohashi H, Kobayashi A, Aburatani H, Kensler TW, Yamamoto M. Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity. Biochemical and Biophysical Research Communications. 339: 79-88. PMID 16293230 DOI: 10.1016/J.Bbrc.2005.10.185 |
0.383 |
|
| 2005 |
Groopman JD, Johnson D, Kensler TW. Aflatoxin and hepatitis B virus biomarkers: a paradigm for complex environmental exposures and cancer risk. Cancer Biomarkers : Section a of Disease Markers. 1: 5-14. PMID 17192028 DOI: 10.3233/Cbm-2005-1103 |
0.554 |
|
| 2005 |
Kensler TW, Chen JG, Egner PA, Fahey JW, Jacobson LP, Stephenson KK, Ye L, Coady JL, Wang JB, Wu Y, Sun Y, Zhang QN, Zhang BC, Zhu YR, Qian GS, et al. Effects of glucosinolate-rich broccoli sprouts on urinary levels of aflatoxin-DNA adducts and phenanthrene tetraols in a randomized clinical trial in He Zuo township, Qidong, People's Republic of China. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 14: 2605-13. PMID 16284385 DOI: 10.1158/1055-9965.Epi-05-0368 |
0.539 |
|
| 2005 |
Healy ZR, Lee NH, Gao X, Goldring MB, Talalay P, Kensler TW, Konstantopoulos K. Divergent responses of chondrocytes and endothelial cells to shear stress: Cross-talk among COX-2, the phase 2 response, and apoptosis Proceedings of the National Academy of Sciences of the United States of America. 102: 14010-14015. PMID 16172382 DOI: 10.1073/Pnas.0506620102 |
0.329 |
|
| 2005 |
Laso N, Mas S, Lafuente MJ, Llobet JM, Molina R, Ballesta A, Kensler TW, Lafuente A. Induction of NAD(P)H quinone oxidoreductase by vegetables widely consumed in Catalonia, Spain. Nutrition and Cancer. 52: 49-58. PMID 16091004 DOI: 10.1207/S15327914Nc5201_7 |
0.325 |
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| 2005 |
Yu X, Kensler T. Nrf2 as a target for cancer chemoprevention. Mutation Research. 591: 93-102. PMID 16054659 DOI: 10.1016/J.Mrfmmm.2005.04.017 |
0.44 |
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| 2005 |
Rangasamy T, Guo J, Mitzner WA, Roman J, Singh A, Fryer AD, Yamamoto M, Kensler TW, Tuder RM, Georas SN, Biswal S. Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice. The Journal of Experimental Medicine. 202: 47-59. PMID 15998787 DOI: 10.1084/Jem.20050538 |
0.34 |
|
| 2005 |
Groopman JD, Kensler TW. Role of metabolism and viruses in aflatoxin-induced liver cancer. Toxicology and Applied Pharmacology. 206: 131-7. PMID 15967201 DOI: 10.1016/J.Taap.2004.09.020 |
0.559 |
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| 2005 |
Fahey JW, Stephenson KK, Dinkova-Kostova AT, Egner PA, Kensler TW, Talalay P. Chlorophyll, chlorophyllin and related tetrapyrroles are significant inducers of mammalian phase 2 cytoprotective genes Carcinogenesis. 26: 1247-1255. PMID 15774490 DOI: 10.1093/Carcin/Bgi068 |
0.324 |
|
| 2004 |
Rangasamy T, Cho CY, Thimmulappa RK, Zhen L, Srisuma SS, Kensler TW, Yamamoto M, Petrache I, Tuder RM, Biswal S. Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice. The Journal of Clinical Investigation. 114: 1248-59. PMID 15520857 DOI: 10.1172/Jci21146 |
0.36 |
|
| 2004 |
Kensler TW, Egner PA, Wang JB, Zhu YR, Zhang BC, Lu PX, Chen JG, Qian GS, Kuang SY, Jackson PE, Gange SJ, Jacobson LP, Muñoz A, Groopman JD. Chemoprevention of hepatocellular carcinoma in aflatoxin endemic areas. Gastroenterology. 127: S310-8. PMID 15508099 DOI: 10.1053/J.Gastro.2004.09.046 |
0.576 |
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| 2004 |
Kwak MK, Wakabayashi N, Kensler TW. Chemoprevention through the Keap1-Nrf2 signaling pathway by phase 2 enzyme inducers. Mutation Research. 555: 133-48. PMID 15476857 DOI: 10.1016/J.Mrfmmm.2004.06.041 |
0.411 |
|
| 2004 |
Anderson SP, Howroyd P, Liu J, Qian X, Bahnemann R, Swanson C, Kwak MK, Kensler TW, Corton JC. The transcriptional response to a peroxisome proliferator-activated receptor alpha agonist includes increased expression of proteome maintenance genes. The Journal of Biological Chemistry. 279: 52390-8. PMID 15375163 DOI: 10.1074/Jbc.M409347200 |
0.4 |
|
| 2004 |
Corton JC, Apte U, Anderson SP, Limaye P, Yoon L, Latendresse J, Dunn C, Everitt JI, Voss KA, Swanson C, Kimbrough C, Wong JS, Gill SS, Chandraratna RA, Kwak MK, ... Kensler TW, et al. Mimetics of caloric restriction include agonists of lipid-activated nuclear receptors. The Journal of Biological Chemistry. 279: 46204-12. PMID 15302862 DOI: 10.1074/Jbc.M406739200 |
0.36 |
|
| 2004 |
Kwak MK, Ramos-Gomez M, Wakabayashi N, Kensler TW. Chemoprevention by 1,2-dithiole-3-thiones through induction of NQO1 and other phase 2 enzymes. Methods in Enzymology. 382: 414-23. PMID 15047114 DOI: 10.1016/S0076-6879(04)82022-6 |
0.403 |
|
| 2004 |
Kuang SY, Jackson PE, Wang JB, Lu PX, Muñoz A, Qian GS, Kensler TW, Groopman JD. Specific mutations of hepatitis B virus in plasma predict liver cancer development. Proceedings of the National Academy of Sciences of the United States of America. 101: 3575-80. PMID 14990795 DOI: 10.1073/Pnas.0308232100 |
0.507 |
|
| 2004 |
Dick RA, Yu X, Kensler TW. NADPH alkenal/one oxidoreductase activity determines sensitivity of cancer cells to the chemotherapeutic alkylating agent irofulven. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 1492-9. PMID 14977853 DOI: 10.1158/1078-0432.Ccr-03-0162 |
0.773 |
|
| 2004 |
Dick RA, Kensler TW. The catalytic and kinetic mechanisms of NADPH-dependent alkenal/one oxidoreductase. The Journal of Biological Chemistry. 279: 17269-77. PMID 14966122 DOI: 10.1074/Jbc.M400427200 |
0.759 |
|
| 2004 |
Wakabayashi N, Dinkova-Kostova AT, Holtzclaw WD, Kang MI, Kobayashi A, Yamamoto M, Kensler TW, Talalay P. Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers Proceedings of the National Academy of Sciences of the United States of America. 101: 2040-2045. PMID 14764894 DOI: 10.1073/Pnas.0307301101 |
0.367 |
|
| 2003 |
Petzer JP, Navamal M, Johnson JK, Kwak MK, Kensler TW, Fishbein JC. Phase 2 enzyme induction by the major metabolite of oltipraz. Chemical Research in Toxicology. 16: 1463-9. PMID 14615973 DOI: 10.1021/Tx034154E |
0.328 |
|
| 2003 |
Kwak MK, Wakabayashi N, Greenlaw JL, Yamamoto M, Kensler TW. Antioxidants enhance mammalian proteasome expression through the Keap1-Nrf2 signaling pathway. Molecular and Cellular Biology. 23: 8786-94. PMID 14612418 DOI: 10.1128/Mcb.23.23.8786-8794.2003 |
0.41 |
|
| 2003 |
Roebuck BD, Curphey TJ, Li Y, Baumgartner KJ, Bodreddigari S, Yan J, Gange SJ, Kensler TW, Sutter TR. Evaluation of the cancer chemopreventive potency of dithiolethione analogs of oltipraz. Carcinogenesis. 24: 1919-28. PMID 14555609 DOI: 10.1093/Carcin/Bgg173 |
0.4 |
|
| 2003 |
Egner PA, Yu X, Johnson JK, Nathasingh CK, Groopman JD, Kensler TW, Roebuck BD. Identification of aflatoxin M1-N7-guanine in liver and urine of tree shrews and rats following administration of aflatoxin B1. Chemical Research in Toxicology. 16: 1174-80. PMID 12971806 DOI: 10.1021/Tx034106U |
0.527 |
|
| 2003 |
Jackson PE, Kuang SY, Wang JB, Strickland PT, Muñoz A, Kensler TW, Qian GS, Groopman JD. Prospective detection of codon 249 mutations in plasma of hepatocellular carcinoma patients. Carcinogenesis. 24: 1657-63. PMID 12869416 DOI: 10.1093/Carcin/Bgg101 |
0.486 |
|
| 2003 |
Kwak MK, Kensler TW, Casero RA. Induction of phase 2 enzymes by serum oxidized polyamines through activation of Nrf2: effect of the polyamine metabolite acrolein. Biochemical and Biophysical Research Communications. 305: 662-70. PMID 12763045 DOI: 10.1016/S0006-291X(03)00834-9 |
0.385 |
|
| 2003 |
Kensler TW, Qian GS, Chen JG, Groopman JD. Translational strategies for cancer prevention in liver. Nature Reviews. Cancer. 3: 321-9. PMID 12724730 DOI: 10.1038/Nrc1076 |
0.553 |
|
| 2003 |
Ramos-Gomez M, Dolan PM, Itoh K, Yamamoto M, Kensler TW. Interactive effects of nrf2 genotype and oltipraz on benzo[a]pyrene-DNA adducts and tumor yield in mice. Carcinogenesis. 24: 461-7. PMID 12663505 DOI: 10.1093/Carcin/24.3.461 |
0.353 |
|
| 2003 |
Egner PA, Muñoz A, Kensler TW. Chemoprevention with chlorophyllin in individuals exposed to dietary aflatoxin. Mutation Research. 523: 209-16. PMID 12628519 DOI: 10.1016/S0027-5107(02)00337-8 |
0.389 |
|
| 2003 |
Guyton KZ, Kensler TW. Prevention of liver cancer. Current Oncology Reports. 4: 464-70. PMID 12354357 DOI: 10.1007/S11912-002-0057-4 |
0.34 |
|
| 2002 |
Kensler TW, Egner PA, Wang JB, Zhu YR, Zhang BC, Qian GS, Kuang SY, Gange SJ, Jacobson LP, Muñoz A, Groopman JD. Strategies for chemoprevention of liver cancer. European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (Ecp). 11: S58-64. PMID 12570336 |
0.525 |
|
| 2002 |
Kwak MK, Wakabayashi N, Itoh K, Motohashi H, Yamamoto M, Kensler TW. Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival. The Journal of Biological Chemistry. 278: 8135-45. PMID 12506115 DOI: 10.1074/Jbc.M211898200 |
0.392 |
|
| 2002 |
Dick RA, Kensler TW. Chemoprotective potential of phase 2 enzyme inducers. Expert Review of Anticancer Therapy. 2: 581-92. PMID 12382526 DOI: 10.1586/14737140.2.5.581 |
0.775 |
|
| 2002 |
Kwak MK, Itoh K, Yamamoto M, Kensler TW. Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents: role of antioxidant response element-like sequences in the nrf2 promoter. Molecular and Cellular Biology. 22: 2883-92. PMID 11940647 DOI: 10.1128/Mcb.22.9.2883-2892.2002 |
0.376 |
|
| 2002 |
Cho HY, Jedlicka AE, Reddy SP, Kensler TW, Yamamoto M, Zhang LY, Kleeberger SR. Role of NRF2 in protection against hyperoxic lung injury in mice. American Journal of Respiratory Cell and Molecular Biology. 26: 175-82. PMID 11804867 DOI: 10.1165/Ajrcmb.26.2.4501 |
0.357 |
|
| 2002 |
Cho HY, Jedlicka AE, Reddy SP, Zhang LY, Kensler TW, Kleeberger SR. Linkage analysis of susceptibility to hyperoxia. Nrf2 is a candidate gene. American Journal of Respiratory Cell and Molecular Biology. 26: 42-51. PMID 11751202 DOI: 10.1165/Ajrcmb.26.1.4536 |
0.34 |
|
| 2001 |
Nelson WG, De Marzo AM, Deweese TL, Lin X, Brooks JD, Putzi MJ, Nelson CP, Groopman JD, Kensler TW. Preneoplastic prostate lesions: an opportunity for prostate cancer prevention. Annals of the New York Academy of Sciences. 952: 135-44. PMID 11795433 DOI: 10.1111/J.1749-6632.2001.Tb02734.X |
0.778 |
|
| 2001 |
Egner PA, Wang JB, Zhu YR, Zhang BC, Wu Y, Zhang QN, Qian GS, Kuang SY, Gange SJ, Jacobson LP, Helzlsouer KJ, Bailey GS, Groopman JD, Kensler TW. Chlorophyllin intervention reduces aflatoxin-DNA adducts in individuals at high risk for liver cancer Proceedings of the National Academy of Sciences of the United States of America. 98: 14601-14606. PMID 11724948 DOI: 10.1073/Pnas.251536898 |
0.558 |
|
| 2001 |
Posner GH, Crawford KR, Peleg S, Welsh JE, Romu S, Gewirtz DA, Gupta MS, Dolan P, Kensler TW. A non-calcemic sulfone version of the vitamin D(3) analogue seocalcitol (EB 1089): chemical synthesis, biological evaluation and potency enhancement of the anticancer drug adriamycin. Bioorganic & Medicinal Chemistry. 9: 2365-71. PMID 11553477 DOI: 10.1016/S0968-0896(01)00159-6 |
0.304 |
|
| 2001 |
Parsons JK, Nelson CP, Gage WR, Nelson WG, Kensler TW, De Marzo AM. GSTA1 expression in normal, preneoplastic, and neoplastic human prostate tissue. The Prostate. 49: 30-7. PMID 11550208 DOI: 10.1002/Pros.1115 |
0.773 |
|
| 2001 |
Dick RA, Kwak MK, Sutter TR, Kensler TW. Antioxidative function and substrate specificity of NAD(P)H-dependent alkenal/one oxidoreductase. A new role for leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase. The Journal of Biological Chemistry. 276: 40803-10. PMID 11524419 DOI: 10.1074/Jbc.M105487200 |
0.759 |
|
| 2001 |
Kwak MK, Egner PA, Dolan PM, Ramos-Gomez M, Groopman JD, Itoh K, Yamamoto M, Kensler TW. Role of phase 2 enzyme induction in chemoprotection by dithiolethiones. Mutation Research. 480: 305-15. PMID 11506823 DOI: 10.1016/S0027-5107(01)00190-7 |
0.611 |
|
| 2001 |
Walton M, Egner P, Scholl PF, Walker J, Kensler TW, Groopman JD. Liquid chromatography electrospray-mass spectrometry of urinary aflatoxin biomarkers: Characterization and application to dosimetry and chemoprevention in rats Chemical Research in Toxicology. 14: 919-926. PMID 11453740 DOI: 10.1021/Tx010063A |
0.519 |
|
| 2001 |
Guyton KZ, Kensler TW, Posner GH. Cancer chemoprevention using natural vitamin D and synthetic analogs. Annual Review of Pharmacology and Toxicology. 41: 421-42. PMID 11264464 DOI: 10.1146/Annurev.Pharmtox.41.1.421 |
0.3 |
|
| 2001 |
Ramos-Gomez M, Kwak MK, Dolan PM, Itoh K, Yamamoto M, Talalay P, Kensler TW. Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice Proceedings of the National Academy of Sciences of the United States of America. 98: 3410-3415. PMID 11248092 DOI: 10.1073/Pnas.051618798 |
0.366 |
|
| 2001 |
Kensler TW, Curphey TJ, Maxiutenko Y, Roebuck BD. Chemoprotection by organosulfur inducers of phase 2 enzymes: dithiolethiones and dithiins. Drug Metabolism and Drug Interactions. 17: 3-22. PMID 11201301 DOI: 10.1515/Dmdi.2000.17.1-4.3 |
0.433 |
|
| 2001 |
Nelson CP, Kidd LC, Sauvageot J, Isaacs WB, De Marzo AM, Groopman JD, Nelson WG, Kensler TW. Protection against 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine cytotoxicity and DNA adduct formation in human prostate by glutathione S-transferase P1. Cancer Research. 61: 103-9. PMID 11196146 |
0.778 |
|
| 2001 |
Kwak M, Itoh K, Yamamoto M, Sutter TR, Kensler TW. Role of Transcription Factor Nrf2 in the Induction of Hepatic Phase 2 and Antioxidative Enzymes in vivo by the Cancer Chemoprotective Agent, 3H-1, 2-Dithiole-3-thione Molecular Medicine. 7: 135-145. DOI: 10.1007/Bf03401947 |
0.403 |
|
| 2000 |
Kensler TW, Dolan PM, Gange SJ, Lee JK, Wang Q, Posner GH. Conceptually new deltanoids (vitamin D analogs) inhibit multistage skin tumorigenesis. Carcinogenesis. 21: 1341-5. PMID 10874012 DOI: 10.1093/Carcin/21.5.341 |
0.323 |
|
| 2000 |
Otieno MA, Kensler TW, Guyton KZ. Chemoprotective 3H-1,2-dithiole-3-thione induces antioxidant genes in vivo. Free Radical Biology & Medicine. 28: 944-52. PMID 10802226 DOI: 10.1016/S0891-5849(00)00175-1 |
0.361 |
|
| 2000 |
Li Y, Su JJ, Qin LL, Egner PA, Wang JS, Groopman JD, Kensler TW, Roebuck BD. Reduction of aflatoxin B1 adduct biomarkers by oltipraz in the tree shrew (Tupaia belangeri chinensis) Cancer Letters. 154: 79-83. PMID 10799742 DOI: 10.1016/S0304-3835(00)00382-7 |
0.568 |
|
| 2000 |
Primiano T, Kensler TW, Trush MA, Sutter TR. Induction of leukotriene B4 metabolism by cancer chemopreventive agents. Advances in Experimental Medicine and Biology. 469: 599-605. PMID 10667388 DOI: 10.1007/978-1-4615-4793-8_87 |
0.382 |
|
| 1999 |
Kensler TW, Tsuda H, Wogan GN. United States-Japan workshop on New Rodent Models for the Analysis and Prevention of Carcinogenesis. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 8: 1033-7. PMID 10566560 |
0.474 |
|
| 1999 |
Wang SS, O'Neill JP, Qian GS, Zhu YR, Wang JB, Armenian H, Zarba A, Wang JS, Kensler TW, Cariello NF, Groopman JD, Swenberg JA. Elevated HPRT mutation frequencies in aflatoxin-exposed residents of daxin, Qidong county, People's Republic of China. Carcinogenesis. 20: 2181-4. PMID 10545423 DOI: 10.1093/Carcin/20.11.2181 |
0.545 |
|
| 1999 |
Knight LP, Primiano T, Groopman JD, Kensler TW, Sutter TR. cDNA cloning, expression and activity of a second human aflatoxin B1-metabolizing member of the aldo-keto reductase superfamily, AKR7A3 Carcinogenesis. 20: 1215-1223. PMID 10383892 DOI: 10.1093/Carcin/20.7.1215 |
0.546 |
|
| 1999 |
Links JM, Kensler TW, Groopman JD. Biomarkers in environmental health research & practice. Drug and Chemical Toxicology. 22: 1-14. PMID 10189567 DOI: 10.3109/01480549909029720 |
0.465 |
|
| 1999 |
Wang JS, Shen X, He X, Zhu YR, Zhang BC, Wang JB, Qian GS, Kuang SY, Zarba A, Egner PA, Jacobson LP, Muñoz A, Helzlsouer KJ, Groopman JD, Kensler TW. Protective alterations in phase 1 and 2 metabolism of aflatoxin B1 oltipraz in residents of Qidong, People's Republic of China Journal of the National Cancer Institute. 91: 347-354. PMID 10050868 DOI: 10.1093/Jnci/91.4.347 |
0.536 |
|
| 1999 |
Kensler TW, Groopman JD, Sutter TR, Curphey TJ, Roebuck BD. Development of cancer chemopreventive agents: Oltipraz as a paradigm Chemical Research in Toxicology. 12: 113-126. PMID 10027787 DOI: 10.1021/Tx980185B |
0.508 |
|
| 1999 |
Groopman JD, Kensler TW. The light at the end of the tunnel for chemical-specific biomarkers: Daylight or headlight? Carcinogenesis. 20: 1-11. PMID 9934843 DOI: 10.1093/Carcin/20.1.1 |
0.544 |
|
| 1998 |
Maxuitenko YY, Libby AH, Joyner HH, Curphey TJ, MacMillan DL, Kensler TW, Roebuck BD. Identification of dithiolethiones with better chemopreventive properties than oltipraz. Carcinogenesis. 19: 1609-15. PMID 9771932 DOI: 10.1093/Carcin/19.9.1609 |
0.393 |
|
| 1998 |
Kensler TW, Groopman JD, Roebuck BD. Use of aflatoxin adducts as intermediate endpoints to assess the efficacy of chemopreventive interventions in animals and man Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 402: 165-172. PMID 9675269 DOI: 10.1016/S0027-5107(97)00294-7 |
0.558 |
|
| 1998 |
Primiano T, Li Y, Kensler TW, Trush MA, Sutter TR. Identification of dithiolethione-inducible gene-1 as a leukotriene B4 12-hydroxydehydrogenase: implications for chemoprevention. Carcinogenesis. 19: 999-1005. PMID 9667737 DOI: 10.1093/Carcin/19.6.999 |
0.38 |
|
| 1998 |
Primiano T, Sutter TR, Kensler TW. Redox regulation of genes that protect against carcinogens. Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology. 118: 487-97. PMID 9467861 DOI: 10.1016/S0305-0491(97)00221-6 |
0.391 |
|
| 1998 |
Berchtold CM, Tamez P, Kensler TW, Casero RA. Inhibition of cell growth in CaCO2 cells by the polyamine analogue N1,N12-bis(ethyl)spermine is preceded by a reduction in MYC oncoprotein levels. Journal of Cellular Physiology. 174: 380-6. PMID 9462700 DOI: 10.1002/(Sici)1097-4652(199803)174:3<380::Aid-Jcp12>3.0.Co;2-D |
0.335 |
|
| 1997 |
Kensler TW. Chemoprevention by inducers of carcinogen detoxication enzymes. Environmental Health Perspectives. 965-70. PMID 9255588 DOI: 10.1289/Ehp.97105S4965 |
0.418 |
|
| 1997 |
Primiano T, Gastel JA, Kensler TW, Sutter TR. Isolation of cDNAs representing dithiolethione-responsive genes. Carcinogenesis. 17: 2297-303. PMID 8968041 DOI: 10.1093/Carcin/17.11.2297 |
0.355 |
|
| 1997 |
Primiano T, Sutter TR, Kensler TW. Antioxidant-inducible genes. Advances in Pharmacology (San Diego, Calif.). 38: 293-328. PMID 8895814 DOI: 10.1016/S1054-3589(08)60989-8 |
0.392 |
|
| 1997 |
Zhang B, Zhu Y, Wang J, Wu Y, Zhang Q, Qian G, Kuang S, Li Y, Fang X, Yu L, De Flora S, Jacobson LP, Zarba A, Egner PA, He X, ... ... Kensler TW, et al. Oltipraz chemoprevention trial in Qidong, Jiangsu Province, People's Republic of China Journal of Cellular Biochemistry. 67: 166-173. DOI: 10.1002/(Sici)1097-4644(1997)28/29+<166::Aid-Jcb20>3.0.Co;2-E |
0.536 |
|
| 1996 |
Kensler TW, Groopman JD. Carcinogen-DNA and protein adducts: Biomarkers for cohort selection and modifiable endpoints in chemoprevention trials Journal of Cellular Biochemistry. 63: 85-91. PMID 9027603 DOI: 10.1002/(Sici)1097-4644(1996)25+<85::Aid-Jcb12>3.0.Co;2-M |
0.559 |
|
| 1996 |
Primiano T, Kensler TW, Kuppusamy P, Zweier JL, Sutter TR. Induction of hepatic heme oxygenase-1 and ferritin in rats by cancer chemopreventive dithiolethiones Carcinogenesis. 17: 2291-2296. PMID 8968040 DOI: 10.1093/Carcin/17.11.2291 |
0.339 |
|
| 1996 |
Kensler TW, Groopman JD, Wogan GN. Use of carcinogen-DNA and carcinogen-protein adduct biomarkers for cohort selection and as modifiable end points in chemoprevention trials. Iarc Scientific Publications. 237-48. PMID 8923034 |
0.643 |
|
| 1996 |
Scholl P, Musser SM, Kensler TW, Groopman JD. Inhibition of aflatoxin Ml excretion in rat urine during dietary intervention with oltipraz. Carcinogenesis. 17: 1385-8. PMID 8681461 DOI: 10.1093/Carcin/17.6.1385 |
0.556 |
|
| 1996 |
King JK, Egner PA, Kensler TW. Generation of DNA base modification following treatment of cultured murine keratinocytes with benzoyl peroxide. Carcinogenesis. 17: 317-20. PMID 8625457 DOI: 10.1093/Carcin/17.2.317 |
0.307 |
|
| 1996 |
MAXUITENKO YY, CURPHEY TJ, KENSLER TW, ROEBUCK BD. Protection against Aflatoxin B1-Induced Hepatic Toxicity as a Short-Term Screen of Cancer Chemopreventive Dithiolethiones Toxicological Sciences. 32: 250-259. DOI: 10.1006/Faat.1996.0128 |
0.357 |
|
| 1996 |
Flora SD, Camoirano A, Bagnasco M, Bennicelli C, Zandwijk NV, Wigbout G, Qian GS, Zhu YR, Kensler TW. Smokers and urinary genotoxins: implications for selection of cohorts and modulation of endpoints in chemoprevention trials. Journal of Cellular Biochemistry. 63: 92-98. DOI: 10.1002/(Sici)1097-4644(1996)25+<92::Aid-Jcb13>3.0.Co;2-P |
0.311 |
|
| 1995 |
Groopman JD, Kensler TW, Links JM. Molecular epidemiology and human risk monitoring Toxicology Letters. 82: 763-769. PMID 8597140 DOI: 10.1016/0378-4274(95)03594-X |
0.514 |
|
| 1995 |
Kensler TW, Helzlsouer KJ. Oltipraz: clinical opportunities for cancer chemoprevention. p Journal of Cellular Biochemistry. Supplement. 22: 101-107. PMID 8538185 DOI: 10.1002/Jcb.240590813 |
0.36 |
|
| 1995 |
Links JM, Kensler TW, Groopman JD. Biomarkers and mechanistic approaches in environmental epidemiology Annual Review of Public Health. 16: 83-103. PMID 7639885 DOI: 10.1146/Annurev.Pu.16.050195.000503 |
0.544 |
|
| 1995 |
Egner PA, Gange SJ, Dolan PM, Groopman JD, Muñoz A, Kensler TW. Levels of aflatoxin-albumin biomarkers in rat plasma are modulated by both long-term and transient interventions with oltipraz Carcinogenesis. 16: 1769-1773. PMID 7634402 DOI: 10.1093/Carcin/16.8.1769 |
0.526 |
|
| 1995 |
Scholl P, Musser SM, Kensler TW, Groopman JD. Molecular biomarkers for aflatoxins and their application to human liver cancer. Pharmacogenetics. 5: S171-6. PMID 7581490 DOI: 10.1097/00008571-199512001-00022 |
0.552 |
|
| 1994 |
Egner PA, Kensler TW, Prestera T, Talalay P, Libby AH, Joyner HH, Curphey TJ. Regulation of phase 2 enzyme induction by oltipraz and other dithiolethiones. Carcinogenesis. 15: 177-81. PMID 8313505 DOI: 10.1093/Carcin/15.2.177 |
0.36 |
|
| 1994 |
Guyton KZ, Thompson JA, Kensler TW. Role of quinone methide in the in vitro toxicity of the skin tumor promoter butylated hydroxytoluene hydroperoxide. Chemical Research in Toxicology. 6: 731-8. PMID 8292753 DOI: 10.1021/Tx00035A020 |
0.344 |
|
| 1994 |
Guyton KZ, Dolan PM, Kensler TW. Quinone methide mediates in vitro induction of ornithine decarboxylase by the tumor promoter butylated hydroxytoluene hydroperoxide. Carcinogenesis. 15: 817-21. PMID 8200081 DOI: 10.1093/Carcin/15.5.817 |
0.328 |
|
| 1994 |
Zhang Y, Kensler TW, Cho CG, Posner GH, Talalay P. Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates. Proceedings of the National Academy of Sciences of the United States of America. 91: 3147-50. PMID 8159717 DOI: 10.1073/Pnas.91.8.3147 |
0.338 |
|
| 1994 |
Groopman JD, Wogan GN, Roebuck BD, Kensler TW. Molecular biomarkers for aflatoxins and their application to human cancer prevention. Cancer Research. 54: 1907s-1911s. PMID 8137310 |
0.646 |
|
| 1994 |
Groopman JD, Roebuck BD, Kensler TW. Carcinogen-DNA and protein adducts as intermediate biomarkers for human chemoprotection trials Advances in Experimental Medicine and Biology. 354: 149-160. PMID 8067283 DOI: 10.1007/978-1-4899-0939-8_11 |
0.557 |
|
| 1993 |
Meyer DJ, Harris JM, Gilmore KS, Coles B, Kensler TW, Ketterer B. Quantitation of tissue- and sex-specific induction of rat GSH transferase subunits by dietary 1,2-dithiole-3-thiones Carcinogenesis. 14: 567-572. PMID 8472316 DOI: 10.1093/Carcin/14.4.567 |
0.317 |
|
| 1993 |
Groopman JD, Wild CP, Hasler J, Junshi C, Wogan GN, Kensler TW. Molecular epidemiology of aflatoxin exposures: validation of aflatoxin-N7-guanine levels in urine as a biomarker in experimental rat models and humans. Environmental Health Perspectives. 99: 107-13. PMID 8319607 DOI: 10.1289/Ehp.9399107 |
0.68 |
|
| 1993 |
Meyer DJ, Coles B, Harris J, Gilmore KS, Raney K, Harris TM, Guengerich FP, Kensler TW, Ketterer B. Induction of rat liver GSH transferases by 1,2-dithiole-3-thione illustrates both anticarcinogenic and tumor-promoting properties. Basic Life Sciences. 61: 171-9. PMID 8304929 DOI: 10.1007/978-1-4615-2984-2_16 |
0.348 |
|
| 1993 |
Kensler TW, Davidson NE, Groopman JD, Roebuck BD, Prochaska HJ, Talalay P. Chemoprotection by inducers of electrophile detoxication enzymes. Basic Life Sciences. 61: 127-36. PMID 8304925 DOI: 10.1007/978-1-4615-2984-2_12 |
0.557 |
|
| 1993 |
Maxuitenko YY, MacMillan DL, Kensler TW, Roebuck BD. Evaluation of the post-initiation effects of oltipraz on aflatoxin B1-induced preneoplastic foci in a rat model of hepatic tumorigenesis. Carcinogenesis. 14: 2423-5. PMID 8242875 DOI: 10.1093/Carcin/14.11.2423 |
0.3 |
|
| 1993 |
Guyton KZ, Kensler TW. Oxidative mechanisms in carcinogenesis. British Medical Bulletin. 49: 523-44. PMID 8221020 DOI: 10.1093/Oxfordjournals.Bmb.A072628 |
0.343 |
|
| 1993 |
Styczynski PB, Blackmon RC, Groopman JD, Kensler TW. The direct glucuronidation of 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP) by human and rabbit liver microsomes. Chemical Research in Toxicology. 6: 846-51. PMID 8117924 DOI: 10.1021/Tx00036A014 |
0.531 |
|
| 1993 |
Groopman JD, Kensler TW. Molecular biomarkers for human chemical carcinogen exposures Chemical Research in Toxicology. 6: 764-770. PMID 8117914 DOI: 10.1021/Tx00036A004 |
0.513 |
|
| 1993 |
Kensler T, Styczynski P, Groopman J, Helzlsouer K, Curphey T, Maxuitenko Y, Roebuck BD. Mechanisms of chemoprotection by oltipraz. Journal of Cellular Biochemistry. Supplement. 167-72. PMID 1305682 DOI: 10.1002/Jcb.240501331 |
0.522 |
|
| 1993 |
Posner GH, Guyton KZ, Kensler TW, Barsony J, Lieberman ME, Reddy GS, Clark JW, Wankadiya KF, Tserng KT. 1-(hydroxyalkyl)-25-hydroxyvitamin D3 analogs of calcitriol. 2. Preliminary biological evaluation Bioorganic and Medicinal Chemistry Letters. 3: 1835-1840. DOI: 10.1016/S0960-894X(00)80115-8 |
0.305 |
|
| 1992 |
Groopman JD, Dematos P, Egner PA, Love-hunt A, Kensler TW. Molecular dosimetry of urinary aflatoxin-N-guanine and serum aflatoxin-albumin adducts predicts chemoprotection by l,2-dithiole-3-thione in rats Carcinogenesis. 13: 101-106. PMID 1733561 DOI: 10.1093/Carcin/13.1.101 |
0.564 |
|
| 1992 |
Kensler TW, Groopman JD, Eaton DL, Curphey TJ, Roebuck BD. Potent inhibition of aflatoxin-induced hepatic tumorigenesis by the monofunctional enzyme inducer l,2-dithiole-3-thione Carcinogenesis. 13: 95-100. PMID 1346373 DOI: 10.1093/Carcin/13.1.95 |
0.561 |
|
| 1991 |
Trush MA, Kensler TW. An overview of the relationship between oxidative stress and chemical carcinogenesis. Free Radical Biology & Medicine. 10: 201-9. PMID 1864525 DOI: 10.1016/0891-5849(91)90077-G |
0.306 |
|
| 1989 |
Taffe BG, Zweier JL, Pannell LK, Kensler TW. Generation of reactive intermediates from the tumor promoter butylated hydroxytoluene hydroperoxide in isolated murine keratinocytes or by hematin. Carcinogenesis. 10: 1261-8. PMID 2472232 DOI: 10.1093/Carcin/10.7.1261 |
0.315 |
|
| 1988 |
Liu YL, Roebuck BD, Yager JD, Groopman JD, Kensler TW. Protection by 5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione (oltipraz) against the hepatotoxicity of aflatoxin B1 in the rat Toxicology and Applied Pharmacology. 93: 442-451. PMID 3130679 DOI: 10.1016/0041-008X(88)90047-6 |
0.528 |
|
| 1988 |
Groopman JD, Cain LG, Kensler TW, Harris CC. Aflatoxin exposure in human populations: Measurements and relationship to cancer Critical Reviews in Toxicology. 19: 113-145. PMID 3069332 DOI: 10.3109/10408448809014902 |
0.554 |
|
| 1987 |
Kensler TW, Egner PA, Moore KG, Taffe BG, Twerdok LE, Trush MA. Role of inflammatory cells in the metabolic activation of polycyclic aromatic hydrocarbons in mouse skin. Toxicology and Applied Pharmacology. 90: 337-46. PMID 3629608 DOI: 10.1016/0041-008X(87)90341-3 |
0.324 |
|
| 1987 |
Groopman JD, Kensler TW. The use of monoclonal antibody affinity columns for assessing DNA damage and repair following exposure to aflatoxin B1 Pharmacology and Therapeutics. 34: 321-334. PMID 3120202 DOI: 10.1016/0163-7258(87)90016-7 |
0.561 |
|
| 1987 |
Groopman JD, Roebuck BD, Kensler TW. Application of monoclonal antibodies and dietary antioxidant-based animal models to define human exposure to aflatoxin B1 Progress in Experimental Tumor Research. Fortschritte Der Experimentellen Tumorforschung. Progres De La Recherche Experimentale Des Tumeurs. 31: 52-62. PMID 2882562 DOI: 10.1159/000413903 |
0.503 |
|
| 1986 |
Trush MA, Kensler TW, Seed JL. Activation of xenobiotics by human polymorphonuclear leukocytes via reactive oxygen-dependent reactions. Advances in Experimental Medicine and Biology. 197: 311-21. PMID 2429521 DOI: 10.1007/978-1-4684-5134-4_28 |
0.303 |
|
| 1985 |
Egner PA, Kensler TW. Effects of a biomimetic superoxide dismutase on complete and multistage carcinogenesis in mouse skin. Carcinogenesis. 6: 1167-72. PMID 3926337 DOI: 10.1093/Carcin/6.8.1167 |
0.311 |
|
| 1985 |
Kensler TW, Egner PA, Trush MA, Bueding E, Groopman JD. Modification of aflatoxin B1 binding to DNA in vivo in rats fed phenolic antioxidants, ethoxyquin and a dithiothione Carcinogenesis. 6: 759-763. PMID 3924431 DOI: 10.1093/Carcin/6.5.759 |
0.559 |
|
| 1985 |
Trush MA, Seed JL, Kensler TW. Oxidant-dependent metabolic activation of polycyclic aromatic hydrocarbons by phorbol ester-stimulated human polymorphonuclear leukocytes: possible link between inflammation and cancer. Proceedings of the National Academy of Sciences of the United States of America. 82: 5194-8. PMID 2991910 DOI: 10.1073/Pnas.82.15.5194 |
0.327 |
|
| 1984 |
Roebuck BD, MacMillan DL, Bush DM, Kensler TW. Modulation of Azaserine-Induced Pancreatic Foci by Phenolic Antioxidants in Rats Journal of the National Cancer Institute. 72: 1405-1410. DOI: 10.1093/Jnci/72.6.1405 |
0.346 |
|
| 1976 |
Kensler TW, Busby WF, Davidson NE, Wogan GN. Effect of hepatocarcinogens on the binding of glucocorticoid receptor complex in rat liver nuclei Cancer Research. 36: 4647-4651. PMID 1000507 |
0.468 |
|
| 1976 |
Kensler TW, Busby WF, Davidson NE, Wogan GN. Aflatoxin inhibition of glucocorticoid binding capacity of rat liver nuclei Bba - General Subjects. 437: 200-210. PMID 181075 DOI: 10.1016/0304-4165(76)90361-5 |
0.449 |
|
| Show low-probability matches. |
