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Year Citation  Score
2021 Sakla M, Breitinger U, Breitinger HG, Mansour S, Tammam SN. Delivery of trans-membrane proteins by liposomes; The effect of liposome size and formulation technique on the efficiency of protein delivery. International Journal of Pharmaceutics. 120879. PMID 34265391 DOI: 10.1016/j.ijpharm.2021.120879  0.32
2021 Breitinger U, Weinländer K, Pechmann Y, Langlhofer G, Enz R, Becker CM, Sticht H, Kneussel M, Villmann C, Breitinger HG. A proline-rich motif in the large intracellular loop of the glycine receptor α1 subunit interacts with the Pleckstrin homology domain of collybistin. Journal of Advanced Research. 29: 95-106. PMID 33842008 DOI: 10.1016/j.jare.2020.09.009  0.32
2021 Breitinger U, Sticht H, Breitinger HG. Modulation of recombinant human alpha 1 glycine receptor by flavonoids and gingerols. Biological Chemistry. PMID 33752269 DOI: 10.1515/hsz-2020-0360  0.32
2021 Breitinger U, Farag NS, Ali NKM, Ahmed M, El-Azizi MA, Breitinger HG. Cell viability assay as a tool to study activity and inhibition of hepatitis C p7 channels. The Journal of General Virology. PMID 33709903 DOI: 10.1099/jgv.0.001571  0.32
2021 Zlotos DP, Abdelmalek CM, Botros LS, Banoub MM, Mandour YM, Breitinger U, El Nady A, Breitinger HG, Sotriffer C, Villmann C, Jensen AA, Holzgrabe U. C-2-Linked Dimeric Strychnine Analogues as Bivalent Ligands Targeting Glycine Receptors. Journal of Natural Products. PMID 33596384 DOI: 10.1021/acs.jnatprod.0c01030  0.32
2020 Sebak AA, Gomaa IEO, ElMeshad AN, Farag MH, Breitinger U, Breitinger HG, AbdelKader MH. Distinct Proteins in Protein Corona of Nanoparticles Represent a Promising Venue for Endogenous Targeting - Part II: In vitro and in vivo Kinetics Study. International Journal of Nanomedicine. 15: 9539-9556. PMID 33299308 DOI: 10.2147/IJN.S273721  0.32
2020 Sebak AA, Gomaa IEO, ElMeshad AN, Farag MH, Breitinger U, Breitinger HG, AbdelKader MH. Distinct Proteins in Protein Corona of Nanoparticles Represent a Promising Venue for Endogenous Targeting - Part I: In vitro Release and Intracellular Uptake Perspective. International Journal of Nanomedicine. 15: 8845-8862. PMID 33204091 DOI: 10.2147/IJN.S273713  0.32
2020 Hussein RA, Ahmed M, Sticht H, Breitinger HG, Breitinger U. Fine-Tuning of Neuronal Ion Channels-Mapping of Residues Involved in Glucose Sensitivity of Recombinant Human Glycine Receptors. Acs Chemical Neuroscience. PMID 33007159 DOI: 10.1021/acschemneuro.0c00566  0.32
2020 Saleh HA, Raafat KM, Temraz TA, Noureldin N, Breitinger HG, Breitinger U. Sarcophine and (7S, 8R)-Dihydroxydeepoxysarcophine from the Red Sea Soft Coral Sarcophyton glaucum as in vitro and in vivo Modulators of Glycine Receptors. Neurotoxicology. PMID 32702364 DOI: 10.1016/j.neuro.2020.07.002  0.32
2020 Breitinger U, Breitinger HG. Modulators of the inhibitory glycine receptor. Acs Chemical Neuroscience. PMID 32391682 DOI: 10.1021/acschemneuro.0c00054  0.32
2020 Langlhofer G, Schaefer N, Maric HM, Keramidas A, Zhang Y, Baumann P, Blum R, Breitinger U, Strømgaard K, Schlosser A, Kessels MM, Koch D, Qualmann B, Breitinger HG, Lynch JW, et al. A novel glycine receptor variant with startle disease affects syndapin I and glycinergic inhibition. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 32354853 DOI: 10.1523/Jneurosci.2490-19.2020  0.32
2019 Hussein RA, Ahmed M, Breitinger HG, Breitinger U. Modulation of Glycine Receptor-Mediated Pain Signaling and by Glucose. Frontiers in Molecular Neuroscience. 12: 280. PMID 31824259 DOI: 10.3389/fnmol.2019.00280  0.32
2019 Ramadan S, Tammam SN, Shetab Boushehri MA, Breitinger HG, Breitinger U, Mansour S, Lamprecht A. Liposomal delivery of functional transmembrane ion channels into the cell membranes of target cells; A potential approach for the treatment of channelopathies. International Journal of Biological Macromolecules. PMID 31756462 DOI: 10.1016/j.ijbiomac.2019.10.238  0.32
2019 Zlotos DP, Mohsen AMY, Mandour YM, Marzouk MA, Breitinger U, Villmann C, Breitinger HG, Sotriffer C, Jensen AA, Holzgrabe U. 11-Aminostrychnine and -(Strychnine-11-yl)propionamide: Synthesis, Configuration, and Pharmacological Evaluation at Glycine Receptors. Journal of Natural Products. PMID 31385511 DOI: 10.1021/Acs.Jnatprod.9B00180  0.32
2019 Hegazy NH, Breitinger HG, Breitinger U. Kavalactones from Kava (Piper methysticum) root extract as modulators of recombinant human glycine receptors. Biological Chemistry. PMID 31141476 DOI: 10.1515/hsz-2019-0112  0.32
2018 Breitinger U, Bahnassawy LM, Janzen D, Roemer V, Becker CM, Villmann C, Breitinger HG. PKA and PKC Modulators Affect Ion Channel Function and Internalization of Recombinant Alpha1 and Alpha1-Beta Glycine Receptors. Frontiers in Molecular Neuroscience. 11: 154. PMID 29867346 DOI: 10.3389/Fnmol.2018.00154  0.32
2018 Mandour YM, Breitinger U, Ma C, Wang J, Boeckler FM, Breitinger HG, Zlotos DP. Symmetric dimeric adamantanes for exploring the structure of two viroporins: influenza virus M2 and hepatitis C virus p7. Drug Design, Development and Therapy. 12: 1019-1031. PMID 29750015 DOI: 10.2147/Dddt.S157104  0.32
2016 Mohsen AM, Mandour YM, Sarukhanyan E, Breitinger U, Villmann C, Banoub MM, Breitinger HG, Dandekar T, Holzgrabe U, Sotriffer C, Jensen AA, Zlotos DP. Oxime Ethers of (E)-11-Isonitrosostrychnine as Highly Potent Glycine Receptor Antagonists. Journal of Natural Products. PMID 27966945 DOI: 10.1021/Acs.Jnatprod.6B00479  0.32
2016 Breitinger U, Farag NS, Ali NK, Breitinger HA. Patch-Clamp Study of Hepatitis C p7 Channels Reveals Genotype-Specific Sensitivity to Inhibitors. Biophysical Journal. 110: 2419-2429. PMID 27276260 DOI: 10.1016/j.bpj.2016.04.018  0.32
2016 Breitinger U, Sticht H, Breitinger HG. Modulation of recombinant human α1 glycine receptors by mono-and disaccharides - a kinetic study. Acs Chemical Neuroscience. PMID 27227552 DOI: 10.1021/acschemneuro.6b00044  0.32
2015 Breitinger U, Breitinger HG. Augmentation of glycine receptor alpha3 currents suggests a mechanism for glucose-mediated analgesia. Neuroscience Letters. PMID 26656729 DOI: 10.1016/j.neulet.2015.11.051  1
2015 Tammam SN, Azzazy HM, Breitinger HG, Lamprecht A. Chitosan Nanoparticles for Nuclear Targeting: The Effect of Nanoparticle Size and Nuclear Localization Sequence Density. Molecular Pharmaceutics. PMID 26465978 DOI: 10.1021/acs.molpharmaceut.5b00478  1
2015 Breitinger U, Raafat KM, Breitinger HG. Glucose is a positive modulator for the activation of human recombinant glycine receptors. Journal of Neurochemistry. 134: 1055-66. PMID 26118987 DOI: 10.1111/jnc.13215  1
2014 Maher A, El-Sayed NS, Breitinger HG, Gad MZ. Overexpression of NMDAR2B in an inflammatory model of Alzheimer's disease: modulation by NOS inhibitors. Brain Research Bulletin. 109: 109-16. PMID 25454121 DOI: 10.1016/j.brainresbull.2014.10.007  1
2014 Maher A, Radwan R, Breitinger HG. In vivo protection against strychnine toxicity in mice by the glycine receptor agonist ivermectin. Biomed Research International. 2014: 640790. PMID 25317421 DOI: 10.1155/2014/640790  1
2014 Meiselbach H, Vogel N, Langlhofer G, Stangl S, Schleyer B, Bahnassawy L, Sticht H, Breitinger HG, Becker CM, Villmann C. Single expressed glycine receptor domains reconstitute functional ion channels without subunit-specific desensitization behavior. The Journal of Biological Chemistry. 289: 29135-47. PMID 25143388 DOI: 10.1074/Jbc.M114.559138  1
2011 Alqazzaz M, Thompson AJ, Price KL, Breitinger HG, Lummis SC. Cys-loop receptor channel blockers also block GLIC. Biophysical Journal. 101: 2912-8. PMID 22208189 DOI: 10.1016/j.bpj.2011.10.055  1
2010 Raafat K, Breitinger U, Mahran L, Ayoub N, Breitinger HG. Synergistic inhibition of glycinergic transmission in vitro and in vivo by flavonoids and strychnine. Toxicological Sciences : An Official Journal of the Society of Toxicology. 118: 171-82. PMID 20719748 DOI: 10.1093/toxsci/kfq245  1
2009 Breitinger HG, Villmann C, Melzer N, Rennert J, Breitinger U, Schwarzinger S, Becker CM. Novel regulatory site within the TM3-4 loop of human recombinant alpha3 glycine receptors determines channel gating and domain structure. The Journal of Biological Chemistry. 284: 28624-33. PMID 19661067 DOI: 10.1074/Jbc.M109.043174  1
2009 Villmann C, Oertel J, Ma-Högemeier ZL, Hollmann M, Sprengel R, Becker K, Breitinger HG, Becker CM. Functional complementation of Glra1(spd-ot), a glycine receptor subunit mutant, by independently expressed C-terminal domains. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 2440-52. PMID 19244519 DOI: 10.1523/Jneurosci.4400-08.2009  1
2008 Becker K, Breitinger HG, Humeny A, Meinck HM, Dietz B, Aksu F, Becker CM. The novel hyperekplexia allele GLRA1(S267N) affects the ethanol site of the glycine receptor. European Journal of Human Genetics : Ejhg. 16: 223-8. PMID 18043720 DOI: 10.1038/sj.ejhg.5201958  1
2005 Paarmann I, Frermann D, Keller BU, Villmann C, Breitinger HG, Hollmann M. Kinetics and subunit composition of NMDA receptors in respiratory-related neurons. Journal of Neurochemistry. 93: 812-24. PMID 15857385 DOI: 10.1111/J.1471-4159.2005.03027.X  1
2004 Breitinger HG, Lanig H, Vohwinkel C, Grewer C, Breitinger U, Clark T, Becker CM. Molecular dynamics simulation links conformation of a pore-flanking region to hyperekplexia-related dysfunction of the inhibitory glycine receptor. Chemistry & Biology. 11: 1339-50. PMID 15489161 DOI: 10.1016/J.Chembiol.2004.07.008  1
2004 Breitinger U, Breitinger HG, Bauer F, Fahmy K, Glockenhammer D, Becker CM. Conserved high affinity ligand binding and membrane association in the native and refolded extracellular domain of the human glycine receptor alpha1-subunit. The Journal of Biological Chemistry. 279: 1627-36. PMID 14593111 DOI: 10.1074/jbc.M303811200  1
2003 Banerjee A, Grewer C, Ramakrishnan L, Jäger J, Gameiro A, Breitinger HG, Gee KR, Carpenter BK, Hess GP. Toward the development of new photolabile protecting groups that can rapidly release bioactive compounds upon photolysis with visible light. The Journal of Organic Chemistry. 68: 8361-7. PMID 14575458 DOI: 10.1021/Jo0300643  1
2003 Breitinger HG. Synthesis and characterization of 2,3-di-O-alkylated amyloses: hydrophobic substitution destabilizes helical conformation. Biopolymers. 69: 301-10. PMID 12833257 DOI: 10.1002/bip.10384  1
2002 Breitinger HG, Becker CM. The inhibitory glycine receptor-simple views of a complicated channel. Chembiochem : a European Journal of Chemical Biology. 3: 1042-52. PMID 12404628 DOI: 10.1002/1439-7633(20021104)3:11<1042::AID-CBIC1042>3.0.CO;2-7  1
2002 Strutz N, Villmann C, Breitinger HG, Werner M, Wenthold RJ, Kizelsztein P, Teichberg VI, Hollmann M. Kainate-binding proteins are rendered functional ion channels upon transplantation of two short pore-flanking domains from a kainate receptor. The Journal of Biological Chemistry. 277: 48035-42. PMID 12370171 DOI: 10.1074/Jbc.M209647200  1
2002 Breitinger HG, Becker CM. Statistical coassembly of glycine receptor alpha1 wildtype and the hyperekplexia mutant alpha1(P250T) in HEK 293 cells: impaired channel function is not dominant in the recombinant system. Neuroscience Letters. 331: 21-4. PMID 12359314 DOI: 10.1016/S0304-3940(02)00773-5  1
2002 Breitinger HG, Villmann C, Rennert J, Ballhausen D, Becker CM. Hydroxylated residues influence desensitization behaviour of recombinant alpha3 glycine receptor channels. Journal of Neurochemistry. 83: 30-6. PMID 12358726 DOI: 10.1046/J.1471-4159.2002.01109.X  1
2002 Breitinger HG. Synthesis of silica-bound amylose by phosphorolytic elongation of immobilised maltoheptaosyl hydrazides Tetrahedron Letters. 43: 6127-6131. DOI: 10.1016/S0040-4039(02)01293-5  1
2001 Breitinger HG. Fast kinetic analysis of ligand-gated ion channels. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 7: 95-103. PMID 11496930  1
2001 Breitinger HG, Geetha N, Hess GP. Inhibition of the serotonin 5-HT3 receptor by nicotine, cocaine, and fluoxetine investigated by rapid chemical kinetic techniques. Biochemistry. 40: 8419-29. PMID 11444989 DOI: 10.1021/Bi0106890  1
2001 Breitinger HG, Villmann C, Becker K, Becker CM. Opposing effects of molecular volume and charge at the hyperekplexia site alpha 1(P250) govern glycine receptor activation and desensitization. The Journal of Biological Chemistry. 276: 29657-63. PMID 11395484 DOI: 10.1074/Jbc.M100446200  1
2000 Hess GP, Ulrich H, Breitinger HG, Niu L, Gameiro AM, Grewer C, Srivastava S, Ippolito JE, Lee SM, Jayaraman V, Coombs SE. Mechanism-based discovery of ligands that counteract inhibition of the nicotinic acetylcholine receptor by cocaine and MK-801. Proceedings of the National Academy of Sciences of the United States of America. 97: 13895-900. PMID 11095713 DOI: 10.1073/Pnas.240459497  1
2000 Adrian K, Bernhard MK, Breitinger HG, Ogilvie A. Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells. Biochimica Et Biophysica Acta. 1492: 127-38. PMID 11004484 DOI: 10.1016/S0167-4781(00)00094-4  1
2000 Breitinger HG, Wieboldt R, Ramesh D, Carpenter BK, Hess GP. Synthesis and characterization of photolabile derivatives of serotonin for chemical kinetic investigations of the serotonin 5-HT(3) receptor. Biochemistry. 39: 5500-8. PMID 10820023 DOI: 10.1021/Bi992781Q  1
1998 Breitinger HG, Becker CM. The inhibitory glycine receptor: prospects for a therapeutic orphan? Current Pharmaceutical Design. 4: 315-34. PMID 10197046  1
1997 Walseth TF, Aarhus R, Gurnack ME, Wong L, Breitinger HG, Gee KR, Lee HC. Preparation of cyclic ADP-ribose antagonists and caged cyclic ADP-ribose. Methods in Enzymology. 280: 294-305. PMID 9211325 DOI: 10.1016/S0076-6879(97)80121-8  1
1997 Breitinger HG, Hess GP. Transient kinetic investigations of the inhibition of the 5-ht-4 serotonin receptor by nicotine Faseb Journal. 11: A969.  1
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