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Jacob T. Cain, Ph.D. - Publications

Affiliations: 
2013 Biology The University of North Dakota, Grand Forks, ND, United States 
Area:
Human Development, Neuroscience Biology, General Biology
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25 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Johnson TB, Brudvig JJ, Likhite S, Pratt MA, White KA, Cain JT, Booth CD, Timm DJ, Davis SS, Meyerink B, Pineda R, Dennys-Rivers C, Kaspar BK, Meyer K, Weimer JM. Early postnatal administration of an AAV9 gene therapy is safe and efficacious in CLN3 disease. Frontiers in Genetics. 14: 1118649. PMID 37035740 DOI: 10.3389/fgene.2023.1118649  0.767
2022 Rechtzigel MJ, Meyerink BL, Leppert H, Johnson TB, Cain JT, Ferrandino G, May DG, Roux KJ, Brudvig JJ, Weimer JM. Transmembrane Batten Disease Proteins Interact With a Shared Network of Vesicle Sorting Proteins, Impacting Their Synaptic Enrichment. Frontiers in Neuroscience. 16: 834780. PMID 35692423 DOI: 10.3389/fnins.2022.834780  0.758
2021 Lu CL, Ortmeier S, Brudvig J, Moretti T, Cain J, Boyadjiev SA, Weimer JM, Kim J. Collagen has a unique SEC24 preference for efficient export from the endoplasmic reticulum. Traffic (Copenhagen, Denmark). PMID 34761479 DOI: 10.1111/tra.12826  0.731
2020 Johnson TB, White KA, Brudvig JJ, Cain JT, Langin L, Pratt MA, Booth CD, Timm DJ, Davis SS, Meyerink B, Likhite S, Meyer K, Weimer JM. AAV9 Gene Therapy Increases Lifespan and Treats Pathological and Behavioral Abnormalities in a Mouse Model of CLN8-Batten Disease. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 33010819 DOI: 10.1016/j.ymthe.2020.09.033  0.778
2020 Johnson TB, Mechels K, Anderson RH, Cain JT, Sturdevant DA, Braddock S, Pinz H, Wilson MA, Landsverk M, Roux KJ, Weimer JM. Author Correction: Characterization of a recurrent missense mutation in the forkhead DNA-binding domain of FOXP1. Scientific Reports. 10: 6635. PMID 32296074 DOI: 10.1038/S41598-020-62950-8  0.571
2020 Johnson TB, Brudvig JJ, Lehtimäki KK, Cain JT, White KA, Bragge T, Rytkönen J, Huhtala T, Timm D, Vihma M, Puoliväli JT, Poutiainen P, Nurmi A, Weimer JM. A multimodal approach to identify clinically relevant biomarkers to comprehensively monitor disease progression in a mouse model of pediatric neurodegenerative disease. Progress in Neurobiology. 101789. PMID 32198061 DOI: 10.1016/J.Pneurobio.2020.101789  0.767
2020 Oksman J, Lehtimäki K, Bragge T, Rytkönen J, Puoliväli J, Poutiainen P, Johnson TB, Cain JT, Davis S, Nurmi A, Weimer J. Principal component analysis (PCA) based data fusion approach for a mouse model of CLN8 Batten disease Molecular Genetics and Metabolism. 129: S119. DOI: 10.1016/J.Ymgme.2019.11.308  0.626
2020 Lehtimäki K, Bragge T, Rytkönen J, Puoliväli J, Poutiainen P, Cerrada-Gimenez M, Kalesnykas G, Johnson TB, Cain JT, Davis S, Nurmi A, Weimer J. Longitudinal characterization of the mouse model of CLN8 Batten disease fine motor performance, retinal degeneration, brain pathology, and metabolic changes Molecular Genetics and Metabolism. 129: S97. DOI: 10.1016/J.Ymgme.2019.11.244  0.624
2019 White KA, Cain JT, Magee H, Yeon SK, Park KD, Khanna R, Weimer JM. Modulation of CRMP2 via ()-Lacosamide shows therapeutic promise but is ultimately ineffective in a mouse model of CLN6-Batten disease. Health Psychology and Behavioral Medicine. 3: NS20190001. PMID 32269836 DOI: 10.1042/NS20190001  0.648
2019 Cain JT, Likhite S, White KA, Timm DJ, Davis SS, Johnson TB, Dennys-Rivers CN, Rinaldi F, Motti D, Corcoran S, Morales P, Pierson C, Hughes SM, Lee SY, Kaspar BK, et al. Gene Therapy Corrects Brain and Behavioral Pathologies in CLN6-Batten Disease. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 31331814 DOI: 10.1016/J.Ymthe.2019.06.015  0.644
2019 Johnson TB, Cain JT, White KA, Ramirez-Montealegre D, Pearce DA, Weimer JM. Therapeutic landscape for Batten disease: current treatments and future prospects. Nature Reviews. Neurology. PMID 30783219 DOI: 10.1038/S41582-019-0138-8  0.693
2019 Poppens MJ, Cain JT, Johnson TB, White KA, Davis SS, Laufmann R, Kloth AD, Weimer JM. Tracking sex-dependent differences in a mouse model of CLN6-Batten disease. Orphanet Journal of Rare Diseases. 14: 19. PMID 30665444 DOI: 10.1186/S13023-019-0994-8  0.676
2019 Weimer J, Cain J, Johnson T, White K, Likhite S, Meyer K. Promise of AAV9 gene therapy in the treatment of Batten disease: Systematic approach in therapy design reduces pathological and behavioral deficits and prolongs survival in mouse models of CLN3-, CLN6-, and CLN8-Batten disease Molecular Genetics and Metabolism. 126: S151. DOI: 10.1016/J.Ymgme.2018.12.390  0.41
2019 Cain JT, Johnson TB, White K, Meyerink B, Staton C, Davis S, Sturdevant D, Bragge T, Huhtala T, Brudvig J, Rytkonen J, Lehtimaki K, Nurmi A, Nurmi A, Weimer J. Identifying a biomarker signature for Batten disease Molecular Genetics and Metabolism. 126: S35-S36. DOI: 10.1016/J.Ymgme.2018.12.070  0.753
2018 Johnson TB, Mechels K, Anderson RE, Cain JT, Sturdevant DA, Braddock S, Pinz H, Wilson MA, Landsverk M, Roux KJ, Weimer JM. Characterization of a recurrent missense mutation in the forkhead DNA-binding domain of FOXP1. Scientific Reports. 8: 16161. PMID 30385778 DOI: 10.1038/S41598-018-34437-0  0.606
2018 Madeo M, Colbert PL, Vermeer DW, Lucido CT, Cain JT, Vichaya EG, Grossberg AJ, Muirhead D, Rickel AP, Hong Z, Zhao J, Weimer JM, Spanos WC, Lee JH, Dantzer R, et al. Cancer exosomes induce tumor innervation. Nature Communications. 9: 4284. PMID 30327461 DOI: 10.1038/S41467-018-06640-0  0.571
2018 Brudvig JJ, Cain JT, Sears RM, Schmidt-Grimminger GG, Wittchen ES, Adler KB, Ghashghaei HT, Weimer JM. MARCKS regulates neuritogenesis and interacts with a CDC42 signaling network. Scientific Reports. 8: 13278. PMID 30185885 DOI: 10.1038/S41598-018-31578-0  0.728
2018 Timm D, Cain JT, Geraets RD, White KA, Koh SY, Kielian T, Pearce DA, Hastings ML, Weimer JM. Searching for novel biomarkers using a mouse model of CLN3-Batten disease. Plos One. 13: e0201470. PMID 30086172 DOI: 10.1371/Journal.Pone.0201470  0.686
2018 White KA, Swier VJ, Cain JT, Kohlmeyer JL, Meyerholz DK, Tanas MR, Uthoff J, Hammond E, Li H, Rohret FA, Goeken A, Chan CH, Leidinger MR, Umesalma S, Wallace MR, et al. A porcine model of neurofibromatosis type 1 that mimics the human disease. Jci Insight. 3. PMID 29925695 DOI: 10.1172/Jci.Insight.120402  0.609
2018 Brudvig JJ, Cain JT, Schmidt-Grimminger GG, Stumpo DJ, Roux KJ, Blackshear PJ, Weimer JM. MARCKS Is Necessary for Netrin-DCC Signaling and Corpus Callosum Formation. Molecular Neurobiology. PMID 29546593 DOI: 10.1007/S12035-018-0990-3  0.714
2017 Geraets RD, Langin LM, Cain JT, Parker CM, Beraldi R, Kovacs AD, Weimer JM, Pearce DA. A tailored mouse model of CLN2 disease: A nonsense mutant for testing personalized therapies. Plos One. 12: e0176526. PMID 28464005 DOI: 10.1371/Journal.Pone.0176526  0.683
2017 Cain JT, Kim DI, Quast M, Shivega WG, Patrick RJ, Moser C, Reuter S, Perez M, Myers A, Weimer JM, Roux KJ, Landsverk M. Nonsense pathogenic variants in exon 1 of PHOX2B lead to translational reinitiation in congenital central hypoventilation syndrome. American Journal of Medical Genetics. Part A. PMID 28371199 DOI: 10.1002/Ajmg.A.38162  0.622
2015 Brudvig J, Cain J. KIS: synaptic plasticity's missing molecular link? The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 2839-41. PMID 25698723 DOI: 10.1523/Jneurosci.5082-14.2015  0.692
2014 Cain JT, Berosik MA, Snyder SD, Crawford NF, Nour SI, Schaubhut GJ, Darland DC. Shifts in the vascular endothelial growth factor isoforms result in transcriptome changes correlated with early neural stem cell proliferation and differentiation in mouse forebrain. Developmental Neurobiology. 74: 63-81. PMID 24124161 DOI: 10.1002/Dneu.22130  0.657
2011 Darland DC, Cain JT, Berosik MA, Saint-Geniez M, Odens PW, Schaubhut GJ, Frisch S, Stemmer-Rachamimov A, Darland T, D'Amore PA. Vascular endothelial growth factor (VEGF) isoform regulation of early forebrain development. Developmental Biology. 358: 9-22. PMID 21803034 DOI: 10.1016/J.Ydbio.2011.06.045  0.645
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