Stuart S. Licht, PhD - Publications

Affiliations: 
2002-2008 Massachusetts Institute of Technology, Cambridge, MA, United States 
 2008-2010 Novartis, Basel, Basel-Stadt, France 
 2010- sanofi-aventis, St. Louis, MO, United States 
Website:
https://www.linkedin.com/pub/stuart-licht/7/57a/610

27 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 McManus J, He T, Gavigan JA, Marchand G, Vougier S, Bedel O, Ferrari P, Arrebola R, Gillespy T, Gregory RC, Licht S, Cheng H, Zhang B, Deng G. A Robust Multiplex Mass Spectrometric Assay for Screening Small-Molecule Inhibitors of CD73 with Diverse Inhibition Modalities. Slas Discovery : Advancing Life Sciences R & D. 2472555217750386. PMID 29336194 DOI: 10.1177/2472555217750386  1
2015 Deng G, Shen J, Yin M, McManus J, Mathieu M, Gee P, He T, Shi C, Bedel O, McLean LR, Le-Strat F, Zhang Y, Marquette JP, Gao Q, Zhang B, ... ... Licht S, et al. Selective inhibition of mutant isocitrate dehydrogenase 1 (IDH1) via disruption of a metal binding network by an allosteric small molecule. The Journal of Biological Chemistry. 290: 762-74. PMID 25391653 DOI: 10.1074/jbc.M114.608497  1
2014 Lin WC, Licht S. Poly(ethylene glycol) as a scaffold for high-affinity open-channel blockers of the mouse nicotinic acetylcholine receptor. Plos One. 9: e112088. PMID 25386750 DOI: 10.1371/journal.pone.0112088  1
2012 Choi KH, Licht S. ATP-sensitive potassium channels exhibit variance in the number of open channels below the limit predicted for identical and independent gating. Plos One. 7: e37399. PMID 22666353 DOI: 10.1371/journal.pone.0037399  1
2010 Tian-Yu J, Licht S, Pardee G, Bhat A, Cao Y, Gao W, Sangalang E, Zaror I. Binding Rate Screen - a high-throughput assay in soluble lysate for prioritizing protein expression constructs. Analytical Biochemistry. 399: 276-83. PMID 19931214 DOI: 10.1016/j.ab.2009.11.012  1
2009 Tantama M, Licht S. Functional equivalence of the nicotinic acetylcholine receptor transmitter binding sites in the open state. Biochimica Et Biophysica Acta. 1788: 936-44. PMID 19366595 DOI: 10.1016/j.bbamem.2009.01.009  1
2008 Farbman ME, Gershenson A, Licht S. Role of a conserved pore residue in the formation of a prehydrolytic high substrate affinity state in the AAA+ chaperone ClpA. Biochemistry. 47: 13497-505. PMID 19053261 DOI: 10.1021/bi801140y  1
2008 Tantama M, Licht S. Use of calculated cation-pi binding energies to predict relative strengths of nicotinic acetylcholine receptor agonists. Acs Chemical Biology. 3: 693-702. PMID 19032090 DOI: 10.1021/cb800189y  1
2008 Tantama M, Lin WC, Licht S. An activity-based protein profiling probe for the nicotinic acetylcholine receptor. Journal of the American Chemical Society. 130: 15766-7. PMID 18975901 DOI: 10.1021/ja805868x  1
2008 Jennings LD, Lun DS, Médard M, Licht S. ClpP hydrolyzes a protein substrate processively in the absence of the ClpA ATPase: mechanistic studies of ATP-independent proteolysis. Biochemistry. 47: 11536-46. PMID 18839965 DOI: 10.1021/bi801101p  1
2008 Jennings LD, Bohon J, Chance MR, Licht S. The ClpP N-terminus coordinates substrate access with protease active site reactivity. Biochemistry. 47: 11031-40. PMID 18816064 DOI: 10.1021/bi8010169  1
2008 Lin WC, Licht S. Polymer-based open-channel blockers for the acetylcholine receptor: the effect of spacer length on blockade kinetics. Biochemistry. 47: 9163-73. PMID 18690702 DOI: 10.1021/bi800737j  1
2008 Bohon J, Jennings LD, Phillips CM, Licht S, Chance MR. Synchrotron protein footprinting supports substrate translocation by ClpA via ATP-induced movements of the D2 loop. Structure (London, England : 1993). 16: 1157-65. PMID 18682217 DOI: 10.1016/j.str.2008.04.016  1
2008 Choi KH, Tantama M, Licht S. Testing for violations of microscopic reversibility in ATP-sensitive potassium channel gating. The Journal of Physical Chemistry. B. 112: 10314-21. PMID 18661924 DOI: 10.1021/jp712088v  1
2008 Licht S, Lee I. Resolving individual steps in the operation of ATP-dependent proteolytic molecular machines: from conformational changes to substrate translocation and processivity. Biochemistry. 47: 3595-605. PMID 18311925 DOI: 10.1021/bi800025g  1
2007 Farbman ME, Gershenson A, Licht S. Single-molecule analysis of nucleotide-dependent substrate binding by the protein unfoldase ClpA. Journal of the American Chemical Society. 129: 12378-9. PMID 17887675 DOI: 10.1021/ja074168x  1
2007 Lun DS, Jennings LD, Koetter R, Licht S, Médard M. An information-based computational technique for estimation of chromatographic peak purity. Journal of Chemical Information and Modeling. 47: 1973-8. PMID 17628056 DOI: 10.1021/ci6005195  1
2005 Choi KH, Licht S. Control of peptide product sizes by the energy-dependent protease ClpAP. Biochemistry. 44: 13921-31. PMID 16229481 DOI: 10.1021/bi0505060  1
2005 Mitra A, Tascione R, Auerbach A, Licht S. Plasticity of acetylcholine receptor gating motions via rate-energy relationships. Biophysical Journal. 89: 3071-8. PMID 16113115 DOI: 10.1529/biophysj.105.068783  1
2003 Licht SS, Sonnleitner A, Weiss S, Schultz PG. A rugged energy landscape mechanism for trapping of transmembrane receptors during endocytosis. Biochemistry. 42: 2916-25. PMID 12627957 DOI: 10.1021/bi026059v  1
1999 Licht SS, Lawrence CC, Stubbe J. Thermodynamic and kinetic studies on carbon-cobalt bond homolysis by ribonucleoside triphosphate reductase: the importance of entropy in catalysis. Biochemistry. 38: 1234-42. PMID 9930983 DOI: 10.1021/bi981886a  1
1999 Licht SS, Booker S, Stubbe J. Studies on the catalysis of carbon-cobalt bond homolysis by ribonucleoside triphosphate reductase: evidence for concerted carbon-cobalt bond homolysis and thiyl radical formation. Biochemistry. 38: 1221-33. PMID 9930982 DOI: 10.1021/bi981885i  1
1999 Licht SS, Lawrence CC, Stubbe J. Class II ribonucleotide reductases catalyze carbon-cobalt bond reformation on every turnover Journal of the American Chemical Society. 121: X. DOI: 10.1021/ja9913840  1
1996 Licht S, Gerfen GJ, Stubbe J. Thiyl radicals in ribonucleotide reductases. Science (New York, N.Y.). 271: 477-81. PMID 8560260  1
1996 Gerfen GJ, Licht S, Willems JP, Hoffman BM, Stubbe J. Electron paramagnetic resonance investigations of a kinetically competent intermediate formed in ribonucleotide reduction: Evidence for a thiyl radical-cob(II)alamin interaction Journal of the American Chemical Society. 118: 8192-8197. DOI: 10.1021/ja960363s  1
1996 Van Der Donk W, Licht S, Da Salva D, McCarthy J, Robins MJ, Stubbe J. Ribonucleotide reductase: no longer confusing but still amazing Faseb Journal. 10: A1086.  1
1994 Booker S, Licht S, Broderick J, Stubbe J. Coenzyme B12-dependent ribonucleotide reductase: evidence for the participation of five cysteine residues in ribonucleotide reduction. Biochemistry. 33: 12676-85. PMID 7918494  0.4
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