Year |
Citation |
Score |
2023 |
Patel AB, He Y, Radhakrishnan I. Histone acetylation and deacetylation - Mechanistic insights from structural biology. Gene. 890: 147798. PMID 37726026 DOI: 10.1016/j.gene.2023.147798 |
0.407 |
|
2023 |
Patel AB, Qing J, Tam KH, Zaman S, Luiso M, Radhakrishnan I, He Y. Cryo-EM structure of the Saccharomyces cerevisiae Rpd3L histone deacetylase complex. Nature Communications. 14: 3061. PMID 37244892 DOI: 10.1038/s41467-023-38687-z |
0.462 |
|
2021 |
Marcum RD, Hsieh J, Giljen M, Justice E, Daffern N, Zhang Y, Radhakrishnan I. A Capped Tudor Domain within a Core Subunit of the Sin3L/Rpd3L Histone Deacetylase Complex Binds to Nucleic Acid G-Quadruplexes. The Journal of Biological Chemistry. 101558. PMID 34979096 DOI: 10.1016/j.jbc.2021.101558 |
0.346 |
|
2020 |
Marcum RD, Radhakrishnan I. The neuronal transcription factor Myt1L interacts via a conserved motif with the PAH1 domain of Sin3 to recruit the Sin3L/Rpd3L histone deacetylase complex. Febs Letters. PMID 32391601 DOI: 10.1002/1873-3468.13811 |
0.38 |
|
2019 |
Marcum RD, Radhakrishnan I. Inositol phosphates and core subunits of the Sin3L/Rpd3L histone deacetylase (HDAC) complex up-regulate deacetylase activity. The Journal of Biological Chemistry. PMID 31358618 DOI: 10.1074/Jbc.Ra119.009780 |
0.386 |
|
2018 |
Daffern N, Chen Z, Zhang Y, Pick L, Radhakrishnan I. Solution NMR Studies of the Ligand-Binding Domain of an Orphan Nuclear Receptor Reveals a Dynamic Helix in the Ligand-Binding Pocket. Biochemistry. PMID 29547262 DOI: 10.1021/Acs.Biochem.8B00069 |
0.365 |
|
2015 |
Clark MD, Zhang Y, Radhakrishnan I. Solution NMR Studies of an Alternative Mode of Sin3 Engagement by the Sds3 Subunit in the Histone Deacetylase-Associated Sin3L/Rpd3L Corepressor Complex. Journal of Molecular Biology. PMID 26522936 DOI: 10.1016/J.Jmb.2015.10.018 |
0.423 |
|
2015 |
Clark M, Kumar GS, Marcum R, Luo Q, Zhang Y, Radhakrishnan I. Molecular Basis for the Mechanism of Constitutive CBP/p300 Coactivator Recruitment by CRTC1-MAML2 and its Implications in cAMP Signaling. Biochemistry. PMID 26274502 DOI: 10.1021/Acs.Biochem.5B00332 |
0.354 |
|
2015 |
Clark MD, Marcum R, Graveline R, Chan CW, Xie T, Chen Z, Ding Y, Zhang Y, Mondragón A, David G, Radhakrishnan I. Structural insights into the assembly of the histone deacetylase-associated Sin3L/Rpd3L corepressor complex. Proceedings of the National Academy of Sciences of the United States of America. PMID 26124119 DOI: 10.1073/Pnas.1504021112 |
0.443 |
|
2015 |
Xie T, Zmyslowski AM, Zhang Y, Radhakrishnan I. Structural Basis for Multi-specificity of MRG Domains. Structure (London, England : 1993). 23: 1049-57. PMID 25960410 DOI: 10.1016/J.Str.2015.03.020 |
0.46 |
|
2015 |
Clark M, Radhakrishnan I. Solution structure of Sds3 in complex with Sin3A Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2N2H/Pdb |
0.383 |
|
2015 |
Xie T, Zmysloski A, Zhang Y, Radhakrishnan I. Solution structure of the MRG15-MRGBP complex Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2N1D/Pdb |
0.383 |
|
2012 |
Luo Q, Viste K, Urday-Zaa JC, Senthil Kumar G, Tsai WW, Talai A, Mayo KE, Montminy M, Radhakrishnan I. Mechanism of CREB recognition and coactivation by the CREB-regulated transcriptional coactivator CRTC2. Proceedings of the National Academy of Sciences of the United States of America. 109: 20865-70. PMID 23213254 DOI: 10.1073/Pnas.1219028109 |
0.416 |
|
2012 |
Kumar GS, Chang W, Xie T, Patel A, Zhang Y, Wang GG, David G, Radhakrishnan I. Sequence requirements for combinatorial recognition of histone H3 by the MRG15 and Pf1 subunits of the Rpd3S/Sin3S corepressor complex. Journal of Molecular Biology. 422: 519-31. PMID 22728643 DOI: 10.1016/J.Jmb.2012.06.013 |
0.371 |
|
2012 |
Xie T, Graveline R, Kumar GS, Zhang Y, Krishnan A, David G, Radhakrishnan I. Structural basis for molecular interactions involving MRG domains: implications in chromatin biology. Structure (London, England : 1993). 20: 151-60. PMID 22244764 DOI: 10.1016/J.Str.2011.10.019 |
0.474 |
|
2011 |
Xie T, He Y, Korkeamaki H, Zhang Y, Imhoff R, Lohi O, Radhakrishnan I. Structure of the 30-kDa Sin3-associated protein (SAP30) in complex with the mammalian Sin3A corepressor and its role in nucleic acid binding. The Journal of Biological Chemistry. 286: 27814-24. PMID 21676866 DOI: 10.1074/Jbc.M111.252494 |
0.572 |
|
2011 |
Filippova EV, Shuvalova L, Minasov G, Kiryukhina O, Zhang Y, Clancy S, Radhakrishnan I, Joachimiak A, Anderson WF. Crystal structure of the novel PaiA N-acetyltransferase from Thermoplasma acidophilum involved in the negative control of sporulation and degradative enzyme production Proteins: Structure, Function and Bioinformatics. 79: 2566-2577. PMID 21633970 DOI: 10.1002/Prot.23062 |
0.403 |
|
2011 |
Kumar GS, Xie T, Zhang Y, Radhakrishnan I. Solution structure of the mSin3A PAH2-Pf1 SID1 complex: a Mad1/Mxd1-like interaction disrupted by MRG15 in the Rpd3S/Sin3S complex. Journal of Molecular Biology. 408: 987-1000. PMID 21440557 DOI: 10.1016/J.Jmb.2011.03.043 |
0.465 |
|
2011 |
Xie T, He Y, Korkeamaki H, Zhang Y, Imhoff R, Lohi O, Radhakrishnan I. solution structure of the mSin3A PAH3-SAP30 SID complex Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2Ld7/Pdb |
0.513 |
|
2011 |
Kumar GS, Xie T, Zhang Y, Radhakrishnan I. Solution structure of Pf1 SID1-mSin3A PAH2 Complex Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2L9S/Pdb |
0.388 |
|
2011 |
Xie T, Patel A, Krishnan A, Zhang Y, Radhakrishnan I. Structure-Function Analysis of MRG15, a Chromatin-Targeting Protein Invovled in Cell Growth and Aging Biophysical Journal. 100: 603a. DOI: 10.1016/J.Bpj.2010.12.3472 |
0.408 |
|
2011 |
Ganesan SK, Xie T, Velagapudi C, Zhang Y, Radhakrishnan I. Structural Analysis of the Pf1 Subunit of the Sin3S/Rpd3S Complex and its Implications in Chromatin Targeting and Complex Assembly Biophysical Journal. 100: 603a. DOI: 10.1016/J.Bpj.2010.12.3471 |
0.442 |
|
2009 |
He Y, Imhoff R, Sahu A, Radhakrishnan I. Solution structure of a novel zinc finger motif in the SAP30 polypeptide of the Sin3 corepressor complex and its potential role in nucleic acid recognition. Nucleic Acids Research. 37: 2142-52. PMID 19223330 DOI: 10.1093/Nar/Gkp051 |
0.584 |
|
2009 |
Radhakrishnan I, He Y, Imhoff R, Sahu A. Solution Structure of the SAP30 zinc finger motif Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2Kdp/Pdb |
0.515 |
|
2008 |
Sahu SC, Swanson KA, Kang RS, Huang K, Brubaker K, Ratcliff K, Radhakrishnan I. Conserved themes in target recognition by the PAH1 and PAH2 domains of the Sin3 transcriptional corepressor. Journal of Molecular Biology. 375: 1444-56. PMID 18089292 DOI: 10.1016/J.Jmb.2007.11.079 |
0.433 |
|
2008 |
He Y, Radhakrishnan I. Solution NMR studies of apo-mSin3A and -mSin3B reveal that the PAH1 and PAH2 domains are structurally independent. Protein Science : a Publication of the Protein Society. 17: 171-5. PMID 18042683 DOI: 10.1110/Ps.073097308 |
0.529 |
|
2007 |
He Y, Hicke L, Radhakrishnan I. Structural basis for ubiquitin recognition by SH3 domains. Journal of Molecular Biology. 373: 190-6. PMID 17765920 DOI: 10.1016/J.Jmb.2007.07.074 |
0.513 |
|
2007 |
Lerch TF, Xu M, Jardetzky TS, Mayo KE, Radhakrishnan I, Kazer R, Shea LD, Woodruff TK. The structures that underlie normal reproductive function Molecular and Cellular Endocrinology. 267: 1-5. PMID 17140726 DOI: 10.1016/J.Mce.2006.10.018 |
0.321 |
|
2006 |
Zhang Y, Zhang Z, Demeler B, Radhakrishnan I. Coupled unfolding and dimerization by the PAH2 domain of the mammalian Sin3A corepressor. Journal of Molecular Biology. 360: 7-14. PMID 16813833 DOI: 10.1016/J.Jmb.2006.04.069 |
0.463 |
|
2006 |
Swanson KA, Hicke L, Radhakrishnan I. Structural basis for monoubiquitin recognition by the Ede1 UBA domain. Journal of Molecular Biology. 358: 713-24. PMID 16563434 DOI: 10.1016/J.Jmb.2006.02.059 |
0.398 |
|
2006 |
Huang K, Wu CW, Sanborn TJ, Patch JA, Kirshenbaum K, Zuckermann RN, Barron AE, Radhakrishnan I. A threaded loop conformation adopted by a family of peptoid nonamers. Journal of the American Chemical Society. 128: 1733-8. PMID 16448149 DOI: 10.1021/Ja0574318 |
0.353 |
|
2006 |
Little TH, Zhang Y, Matulis CK, Weck J, Zhang Z, Ramachandran A, Mayo KE, Radhakrishnan I. Sequence-specific deoxyribonucleic acid (DNA) recognition by steroidogenic factor 1: a helix at the carboxy terminus of the DNA binding domain is necessary for complex stability. Molecular Endocrinology (Baltimore, Md.). 20: 831-43. PMID 16339274 DOI: 10.1210/Me.2005-0384 |
0.445 |
|
2005 |
French M, Swanson K, Shih SC, Radhakrishnan I, Hicke L. Identification and characterization of modular domains that bind ubiquitin. Methods in Enzymology. 399: 135-57. PMID 16338353 DOI: 10.1016/S0076-6879(05)99009-5 |
0.353 |
|
2004 |
Pham JW, Radhakrishnan I, Sontheimer EJ. Thermodynamic and structural characterization of 2'-nitrogen-modified RNA duplexes. Nucleic Acids Research. 32: 3446-55. PMID 15247335 DOI: 10.1093/Nar/Gkh658 |
0.365 |
|
2004 |
Swanson KA, Knoepfler PS, Huang K, Kang RS, Cowley SM, Laherty CD, Eisenman RN, Radhakrishnan I. HBP1 and Mad1 repressors bind the Sin3 corepressor PAH2 domain with opposite helical orientations. Nature Structural & Molecular Biology. 11: 738-46. PMID 15235594 DOI: 10.1038/Nsmb798 |
0.434 |
|
2004 |
Salerno WJ, Seaver SM, Armstrong BR, Radhakrishnan I. MONSTER: inferring non-covalent interactions in macromolecular structures from atomic coordinate data. Nucleic Acids Research. 32: W566-8. PMID 15215451 DOI: 10.1093/Nar/Gkh434 |
0.307 |
|
2004 |
Cowley SM, Kang RS, Frangioni JV, Yada JJ, DeGrand AM, Radhakrishnan I, Eisenman RN. Functional analysis of the Mad1-mSin3A repressor-corepressor interaction reveals determinants of specificity, affinity, and transcriptional response. Molecular and Cellular Biology. 24: 2698-709. PMID 15024060 DOI: 10.1128/Mcb.24.7.2698-2709.2004 |
0.406 |
|
2003 |
Swanson KA, Kang RS, Stamenova SD, Hicke L, Radhakrishnan I. Solution structure of Vps27 UIM-ubiquitin complex important for endosomal sorting and receptor downregulation. The Embo Journal. 22: 4597-606. PMID 12970172 DOI: 10.1093/Emboj/Cdg471 |
0.359 |
|
2003 |
Kang RS, Daniels CM, Francis SA, Shih SC, Salerno WJ, Hicke L, Radhakrishnan I. Solution structure of a CUE-ubiquitin complex reveals a conserved mode of ubiquitin binding. Cell. 113: 621-30. PMID 12787503 DOI: 10.1016/S0092-8674(03)00362-3 |
0.403 |
|
2002 |
Tai LJ, McFall SM, Huang K, Demeler B, Fox SG, Brubaker K, Radhakrishnan I, Morimoto RI. Structure-function analysis of the heat shock factor-binding protein reveals a protein composed solely of a highly conserved and dynamic coiled-coil trimerization domain. The Journal of Biological Chemistry. 277: 735-45. PMID 11679589 DOI: 10.1074/Jbc.M108604200 |
0.393 |
|
2000 |
Tsui V, Radhakrishnan I, Wright PE, Case DA. NMR and molecular dynamics studies of the hydration of a zinc finger-DNA complex Journal of Molecular Biology. 302: 1101-1117. PMID 11183777 DOI: 10.1006/Jmbi.2000.4108 |
0.427 |
|
2000 |
Brubaker K, Cowley SM, Huang K, Loo L, Yochum GS, Ayer DE, Eisenman RN, Radhakrishnan I. Solution structure of the interacting domains of the Mad-Sin3 complex: implications for recruitment of a chromatin-modifying complex. Cell. 103: 655-65. PMID 11106735 DOI: 10.1016/S0092-8674(00)00168-9 |
0.465 |
|
1999 |
Parker D, Rivera M, Zor T, Henrion-Caude A, Radhakrishnan I, Kumar A, Shapiro LH, Wright PE, Montminy M, Brindle PK. Role of secondary structure in discrimination between constitutive and inducible activators. Molecular and Cellular Biology. 19: 5601-7. PMID 10409749 DOI: 10.1128/Mcb.19.8.5601 |
0.399 |
|
1999 |
Radhakrishnan I, Pérez-Alvarado GC, Parker D, Dyson HJ, Montminy MR, Wright PE. Structural analyses of CREB-CBP transcriptional activator-coactivator complexes by NMR spectroscopy: implications for mapping the boundaries of structural domains. Journal of Molecular Biology. 287: 859-65. PMID 10222196 DOI: 10.1006/Jmbi.1999.2658 |
0.457 |
|
1998 |
Parker D, Jhala US, Radhakrishnan I, Yaffe MB, Reyes C, Shulman AI, Cantley LC, Wright PE, Montminy M. Analysis of an activator:coactivator complex reveals an essential role for secondary structure in transcriptional activation. Molecular Cell. 2: 353-9. PMID 9774973 DOI: 10.1016/S1097-2765(00)80279-8 |
0.387 |
|
1998 |
Foster MP, Wuttke DS, Clemens KR, Jahnke W, Radhakrishnan I, Tennant L, Reymond M, Chung J, Wright PE. Chemical shift as a probe of molecular interfaces: NMR studies of DNA binding by the three amino-terminal zinc finger domains from transcription factor IIIA. Journal of Biomolecular Nmr. 12: 51-71. PMID 9729788 DOI: 10.1023/A:1008290631575 |
0.49 |
|
1998 |
Radhakrishnan I, Pérez-Alvarado GC, Dyson HJ, Wright PE. Conformational preferences in the Ser133-phosphorylated and non-phosphorylated forms of the kinase inducible transactivation domain of CREB. Febs Letters. 430: 317-22. PMID 9688563 DOI: 10.1016/S0014-5793(98)00680-2 |
0.379 |
|
1998 |
Radhakrishnan I, Pérez-Alvarado GC, Parker D, Dyson HJ, Montminy MR, Wright PE. Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: a model for activator:coactivator interactions. Cell. 91: 741-52. PMID 9413984 DOI: 10.1016/S0092-8674(00)80463-8 |
0.41 |
|
1997 |
Foster MP, Wuttke DS, Radhakrishnan I, Case DA, Gottesfeld JM, Wright PE. Domain packing and dynamics in the DNA complex of the N-terminal zinc fingers of TFIIIA. Nature Structural Biology. 4: 605-8. PMID 9253405 DOI: 10.1038/Nsb0897-605 |
0.437 |
|
1996 |
Greenbaum NL, Radhakrishnan I, Patel DJ, Hirsh D. Solution structure of the donor site of a trans-splicing RNA. Structure (London, England : 1993). 4: 725-33. PMID 8805553 DOI: 10.1016/S0969-2126(96)00078-0 |
0.678 |
|
1995 |
Greenbaum NL, Radhakrishnan I, Hirsh D, Patel DJ. Determination of the folding topology of the SL1 RNA from Caenorhabditis elegans by multidimensional heteronuclear NMR. Journal of Molecular Biology. 252: 314-27. PMID 7563053 DOI: 10.1006/Jmbi.1995.0499 |
0.712 |
|
1994 |
Radhakrishnan I, Patel DJ. Hydration sites in purine.purine.pyrimidine and pyrimidine.purine.pyrimidine DNA triplexes in aqueous solution. Structure (London, England : 1993). 2: 395-405. PMID 8081755 DOI: 10.1016/S0969-2126(00)00041-1 |
0.589 |
|
1994 |
Radhakrishnan I, Patel DJ. Solution structure of a pyrimidine.purine.pyrimidine DNA triplex containing T.AT, C+.GC and G.TA triples. Structure (London, England : 1993). 2: 17-32. PMID 8075980 DOI: 10.1016/S0969-2126(00)00005-8 |
0.605 |
|
1994 |
Radhakrishnan I, Patel DJ. Solution structure of a purine.purine.pyrimidine DNA triplex containing G.GC and T.AT triples. Structure (London, England : 1993). 1: 135-52. PMID 8069626 DOI: 10.1016/0969-2126(93)90028-F |
0.579 |
|
1994 |
Radhakrishnan I, Patel DJ. Solution structure and hydration patterns of a pyrimidine.purine.pyrimidine DNA triplex containing a novel T.CG base-triple. Journal of Molecular Biology. 241: 600-19. PMID 8057381 DOI: 10.1006/Jmbi.1994.1534 |
0.588 |
|
1994 |
Radhakrishnan I, Patel DJ. DNA triplexes: solution structures, hydration sites, energetics, interactions, and function. Biochemistry. 33: 11405-16. PMID 7522550 DOI: 10.1021/Bi00204A001 |
0.567 |
|
1993 |
Radhakrishnan I, de los Santos C, Patel DJ. Nuclear magnetic resonance structural studies of A.AT base triple alignments in intramolecular purine.purine.pyrimidine DNA triplexes in solution. Journal of Molecular Biology. 234: 188-97. PMID 8230198 DOI: 10.1006/Jmbi.1993.1573 |
0.557 |
|
1993 |
Radhakrishnan I, Patel DJ, Priestly ES, Nash HM, Dervan PB. NMR structural studies on a nonnatural deoxyribonucleoside which mediates recognition of GC base pairs in pyrimidine-purine-pyrimidine DNA triplexes. Biochemistry. 32: 11228-34. PMID 8218188 DOI: 10.1021/Bi00092A037 |
0.573 |
|
1993 |
Radhakrishnan I, Patel DJ. Solution/structure of an intramolecular purine-purine-pyrimidine DNA triplex Journal of the American Chemical Society. 115: 1615-1617. DOI: 10.1021/Ja00057A078 |
0.571 |
|
1992 |
Radhakrishnan I, Patel DJ, Gao X. Three-dimensional homonuclear NOESY-TOCSY of an intramolecular pyrimidine.purine.pyrimidine DNA triplex containing a central G.TA triple: nonexchangeable proton assignments and structural implications. Biochemistry. 31: 2514-23. PMID 1547235 DOI: 10.1021/Bi00124A011 |
0.689 |
|
1992 |
Radhakrishnan I, Patel DJ, Veal JM, Gao X. Solution conformation of a G.cntdot.TA [guanosine.cntdot.thymidine-5'-adenylic acid] triple in an intramolecular pyrimidine.cntdot.purine.cntdot.pyrimidine DNA triplex Journal of the American Chemical Society. 114: 6913-6915. DOI: 10.1021/Ja00043A045 |
0.668 |
|
1991 |
Radhakrishnan I, Gao X, de los Santos C, Live D, Patel DJ. NMR structural studies of intramolecular (Y+)n.(R+)n(Y-)nDNA triplexes in solution: imino and amino proton and nitrogen markers of G.TA base triple formation. Biochemistry. 30: 9022-30. PMID 1654085 DOI: 10.1021/Bi00101A016 |
0.656 |
|
1991 |
Radhakrishnan I, Patel D, Gao X. NMR assignment strategy for DNA protons through three-dimensional proton-proton connectivities. Application to an intramolecular DNA triplex Journal of the American Chemical Society. 113: 8542-8544. DOI: 10.1021/Ja00022A063 |
0.655 |
|
1991 |
Radhakrishnan I, de los Santos C, Patel DJ. Nuclear magnetic resonance structural studies of intramolecular purine · purine · pyrimidine DNA triplexes in solution Journal of Molecular Biology. 221: 1403-1418. DOI: 10.1016/0022-2836(91)90941-X |
0.51 |
|
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