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Jin Zhang, Ph.D. - Publications

Affiliations: 
Pharmacology and Molecular Sciences Johns Hopkins University School of Medicine, Baltimore, MD, United States 
Area:
Spatiotemporal Regulation Dynamics of Intracellular Signaling
Website:
http://www.hopkinsmedicine.org/pharmacology_molecular_sciences/faculty/bios/zhang.html
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137 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Mehta S, Zhang J. Biochemical Activity Architectures Visualized-Using Genetically Encoded Fluorescent Biosensors to Map the Spatial Boundaries of Signaling Compartments. Accounts of Chemical Research. PMID 33949851 DOI: 10.1021/acs.accounts.1c00056  0.319
2020 Zhang JZ, Nguyen AH, Miyamoto S, Heller Brown J, McCulloch AD, Zhang J. Histamine-induced biphasic activation of RhoA allows for persistent RhoA signaling. Plos Biology. 18: e3000866. PMID 32881857 DOI: 10.1371/Journal.Pbio.3000866  0.387
2020 Zhang JZ, Lu TW, Stolerman LM, Tenner B, Yang JR, Zhang JF, Falcke M, Rangamani P, Taylor SS, Mehta S, Zhang J. Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogenic Signaling. Cell. PMID 32846158 DOI: 10.1016/J.Cell.2020.07.043  0.393
2020 Zhou X, Mehta S, Zhang J. Genetically Encodable Fluorescent and Bioluminescent Biosensors Light Up Signaling Networks. Trends in Biochemical Sciences. PMID 32660810 DOI: 10.1016/J.Tibs.2020.06.001  0.331
2020 Keyes J, Ganesan A, Molinar-Inglis O, Hamidzadeh A, Zhang J, Ling M, Trejo J, Levchenko A, Zhang J. Signaling diversity enabled by Rap1-regulated plasma membrane ERK with distinct temporal dynamics. Elife. 9. PMID 32452765 DOI: 10.7554/Elife.57410  0.424
2020 Mo GCH, Posner C, Rodriguez EA, Sun T, Zhang J. A rationally enhanced red fluorescent protein expands the utility of FRET biosensors. Nature Communications. 11: 1848. PMID 32296061 DOI: 10.1038/S41467-020-15687-X  0.388
2020 Lee HN, Mehta S, Zhang J. Recent advances in the use of genetically encodable optical tools to elicit and monitor signaling events. Current Opinion in Cell Biology. 63: 114-124. PMID 32058267 DOI: 10.1016/J.Ceb.2020.01.007  0.378
2020 Schmitt DL, Mehta S, Zhang J. Illuminating the kinome: Visualizing real-time kinase activity in biological systems using genetically encoded fluorescent protein-based biosensors. Current Opinion in Chemical Biology. 54: 63-69. PMID 31911398 DOI: 10.1016/J.Cbpa.2019.11.005  0.368
2020 Keyes J, Ganesan A, Molinar-Inglis O, Hamidzadeh A, Zhang J, Ling M, Trejo J, Levchenko A, Zhang J. Author response: Signaling diversity enabled by Rap1-regulated plasma membrane ERK with distinct temporal dynamics Elife. DOI: 10.7554/Elife.57410.Sa2  0.321
2020 Kwon Y, Clark MJ, Keyes J, Walters G, Sunahara RK, Zhang J. Spatiotemporal Control of ERK Activity by b 2 ‐adrenergic Signaling The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.07537  0.323
2020 Zhong Y, Zhou X, Guan K, Zhang J. Constitutively Active Rheb Regulates Nuclear mTORC1 Activity and Function The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.07130  0.31
2020 Lin W, Phatarphekar A, Greenwald EC, Zhang J. A Light‐gated Integrator for Imaging Kinase Activity in Living Cells The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.05541  0.321
2020 Zhou X, Zhong Y, Kunkel MT, Newton AC, Zhang J. Tracking mTORC1 Activity in the Nucleus: Distinct Regulation Revealed by Locationspecific Inhibition of Akt The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.04692  0.312
2020 Garcia A, Molinar-Inglis O, Nicholas D, Keyes J, Adame J, Cisneros M, Lawson M, Zhang J, Trejo J. Improved fractionation method demonstrates phosphorylated Akt is localized to the cytoplasm in LβT2 cells The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.04608  0.306
2020 Zhang JZ, Lu T, Tenner B, Yang J, Zhang J, Taylor S, Mehta S, Zhang J. PKA RIα phase separation drives cAMP compartmentation and suppresses tumorigenic signaling The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.03204  0.301
2020 Keyes J, Ganesan A, Molinar-Inglis O, Hamidzadeh A, Ling M, Trejo J, Levchenko A, Zhang J. Signaling Diversity Enabled by Rap1 and cAMP/PKA‐Regulated Plasma Membrane ERK with Distinct Temporal Dynamics The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.00680  0.313
2020 Zhang J. Illuminating the Biochemical Activity Architecture of the Cell The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.00385  0.301
2019 Qin Q, Laub S, Shi Y, Ouyang M, Peng Q, Zhang J, Wang Y, Lu S. for Ratiometric and High-Throughput Live-Cell Image Visualization and Quantitation. Frontiers in Physics. 7. PMID 33163483 DOI: 10.3389/Fphy.2019.00154  0.307
2019 Hertel F, Li S, Chen M, Pott L, Mehta S, Zhang J. Fluorescent biosensors for multiplexed imaging of phosphoinositide dynamics. Acs Chemical Biology. PMID 31855412 DOI: 10.1021/Acschembio.9B00691  0.368
2019 Ohadi D, Schmitt DL, Calabrese B, Halpain S, Zhang J, Rangamani P. Computational Modeling Reveals Frequency Modulation of Calcium-cAMP/PKA Pathway in Dendritic Spines. Biophysical Journal. PMID 31668749 DOI: 10.1016/J.Bpj.2019.10.003  0.305
2019 Lin W, Mehta S, Zhang J. Genetically encoded fluorescent biosensors illuminate kinase signaling in cancer. The Journal of Biological Chemistry. PMID 31434714 DOI: 10.1074/Jbc.Rev119.006177  0.372
2018 Greenwald EC, Mehta S, Zhang J. Genetically Encoded Fluorescent Biosensors Illuminate the Spatiotemporal Regulation of Signaling Networks. Chemical Reviews. PMID 30550275 DOI: 10.1021/Acs.Chemrev.8B00333  0.352
2018 Mehta S, Zhang Y, Roth RH, Zhang JF, Mo A, Tenner B, Huganir RL, Zhang J. Single-fluorophore biosensors for sensitive and multiplexed detection of signalling activities. Nature Cell Biology. 20: 1215-1225. PMID 30250062 DOI: 10.1038/S41556-018-0200-6  0.37
2018 Grimsey NJ, Narala R, Rada CC, Mehta S, Stephens BS, Kufareva I, Lapek J, Gonzalez DJ, Handel TM, Zhang J, Trejo J. A Tyrosine Switch on NEDD4-2 E3 Ligase Transmits GPCR Inflammatory Signaling. Cell Reports. 24: 3312-3323.e5. PMID 30232011 DOI: 10.1016/J.Celrep.2018.08.061  0.342
2018 Liu SL, Wang ZG, Hu Y, Xin Y, Singaram I, Gorai S, Zhou X, Shim Y, Min JH, Gong LW, Hay N, Zhang J, Cho W. Quantitative Lipid Imaging Reveals a New Signaling Function of Phosphatidylinositol-3,4-Bisphophate: Isoform- and Site-Specific Activation of Akt. Molecular Cell. PMID 30174291 DOI: 10.1016/J.Molcel.2018.07.035  0.365
2018 Ross BL, Tenner B, Markwardt ML, Zviman A, Shi G, Kerr JP, Snell NE, McFarland JJ, Mauban JR, Ward CW, Rizzo MA, Zhang J. Single-color, ratiometric biosensors for detecting signaling activities in live cells. Elife. 7. PMID 29968564 DOI: 10.7554/Elife.35458  0.359
2018 Oldach LM, Gorshkov K, Mills WT, Zhang J, Meffert MK. A Biosensor for MAPK-Dependent Lin28 Signaling. Molecular Biology of the Cell. PMID 29540527 DOI: 10.1091/Mbc.E17-08-0500  0.588
2018 Ross BL, Tenner B, Markwardt ML, Zviman A, Shi G, Kerr JP, Snell NE, McFarland JJ, Mauban JR, Ward CW, Rizzo MA, Zhang J. Author response: Single-color, ratiometric biosensors for detecting signaling activities in live cells Elife. DOI: 10.7554/Elife.35458.037  0.336
2018 Zhang J. Illuminating the Biochemical Activity Architecture of the Cell Biophysical Journal. 114. DOI: 10.1016/J.Bpj.2017.11.2223  0.301
2017 Nygren PJ, Mehta S, Schweppe DK, Langeberg LK, Whiting JL, Weisbrod CR, Bruce JE, Zhang J, Veesler D, Scott JD. Intrinsic disorder within AKAP79 fine-tunes anchored phosphatase activity toward substrates and drug sensitivity. Elife. 6. PMID 28967377 DOI: 10.7554/Elife.30872  0.311
2017 Chen Y, Booth C, Wang H, Wang R, Terzi D, Zachariou V, Jiao K, Zhang J, Wang Q. Effective attenuation of adenosine A1R signaling by neurabin requires oligomerization of neurabin. Molecular Pharmacology. PMID 28954816 DOI: 10.1124/Mol.117.109462  0.321
2017 Mehta S, Zhang J. Illuminating the cell's biochemical activity architecture. Biochemistry. PMID 28718621 DOI: 10.1021/Acs.Biochem.7B00561  0.343
2017 Ni Q, Mehta S, Zhang J. Live-cell imaging of cell signaling using genetically encoded fluorescent reporters. The Febs Journal. PMID 28613457 DOI: 10.1111/Febs.14134  0.374
2017 Newman RH, Zhang J. Integrated Strategies to Gain a Systems-Level View of Dynamic Signaling Networks. Methods in Enzymology. 589: 133-170. PMID 28336062 DOI: 10.1016/Bs.Mie.2017.01.016  0.331
2017 Mo GC, Ross B, Hertel F, Manna P, Yang X, Greenwald E, Booth C, Plummer AM, Tenner B, Chen Z, Wang Y, Kennedy EJ, Cole PA, Fleming KG, Palmer A, ... ... Zhang J, et al. Genetically encoded biosensors for visualizing live-cell biochemical activity at super-resolution. Nature Methods. PMID 28288122 DOI: 10.1038/Nmeth.4221  0.357
2017 Gorshkov K, Mehta S, Ramamurthy S, Ronnett GV, Zhou FQ, Zhang J. AKAP-mediated feedback control of cAMP gradients in developing hippocampal neurons. Nature Chemical Biology. PMID 28192412 DOI: 10.1038/Nchembio.2298  0.583
2016 Zhou X, Li S, Zhang J. Tracking the Activity of mTORC1 in Living Cells Using Genetically Encoded FRET-based Biosensor TORCAR. Current Protocols in Chemical Biology. 8: 225-233. PMID 27925667 DOI: 10.1002/Cpch.11  0.402
2016 Moore BS, Stepanchick AN, Tewson PH, Hartle CM, Zhang J, Quinn AM, Hughes TE, Mirshahi T. Cilia have high cAMP levels that are inhibited by Sonic Hedgehog-regulated calcium dynamics. Proceedings of the National Academy of Sciences of the United States of America. PMID 27799542 DOI: 10.1073/Pnas.1602393113  0.386
2016 Behar J, Ganesan A, Zhang J, Yaniv Y. The Autonomic Nervous System Regulates the Heart Rate through cAMP-PKA Dependent and Independent Coupled-Clock Pacemaker Cell Mechanisms. Frontiers in Physiology. 7: 419. PMID 27729868 DOI: 10.3389/Fphys.2016.00419  0.318
2016 Conlon P, Gelin-Licht R, Ganesan A, Zhang J, Levchenko A. Single-cell dynamics and variability of MAPK activity in a yeast differentiation pathway. Proceedings of the National Academy of Sciences of the United States of America. PMID 27651485 DOI: 10.1073/Pnas.1610081113  0.371
2016 Ross B, Mehta S, Zhang J. Molecular tools for acute spatiotemporal manipulation of signal transduction. Current Opinion in Chemical Biology. 34: 135-142. PMID 27639090 DOI: 10.1016/J.Cbpa.2016.08.012  0.359
2016 Tenner B, Mehta S, Zhang J. Optical sensors to gain mechanistic insights into signaling assemblies. Current Opinion in Structural Biology. 41: 203-210. PMID 27611602 DOI: 10.1016/J.Sbi.2016.07.021  0.348
2016 Hung WC, Yang JR, Yankaskas CL, Wong BS, Wu PH, Pardo-Pastor C, Serra SA, Chiang MJ, Gu Z, Wirtz D, Valverde MA, Yang JT, Zhang J, Konstantopoulos K. Confinement-Sensing and Signal Optimization via Piezo1/PKA and Myosin II Pathways. Cell Reports. PMID 27160899 DOI: 10.1016/J.Celrep.2016.04.035  0.355
2016 Hertel F, Zhang J. A New Class of Targetable, Genetically Encoded Single-Color Biosensors for Multiplexed Monitoring of Phosphoinositides Biophysical Journal. 110: 336. DOI: 10.1016/J.Bpj.2015.11.1809  0.356
2015 Head SA, Shi W, Zhao L, Gorshkov K, Pasunooti K, Chen Y, Deng Z, Li RJ, Shim JS, Tan W, Hartung T, Zhang J, Zhao Y, Colombini M, Liu JO. Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 26655341 DOI: 10.1073/Pnas.1512867112  0.585
2015 Hu J, Neiswinger J, Zhang J, Zhu H, Qian J. Systematic Prediction of Scaffold Proteins Reveals New Design Principles in Scaffold-Mediated Signal Transduction. Plos Computational Biology. 11: e1004508. PMID 26393507 DOI: 10.1371/Journal.Pcbi.1004508  0.332
2015 Karlsson I, Zhou X, Thomas R, Smith AT, Bonner MY, Bakshi P, Banga AK, Bowen JP, Qabaja G, Ford SL, Ballard MD, Petersen KS, Li X, Chen G, Ogretmen B, Zhang J, et al. Solenopsin A and analogs exhibit ceramide-like biological activity. Vascular Cell. 7: 5. PMID 26015865 DOI: 10.1186/S13221-015-0030-2  0.334
2015 Miyamoto T, Rho E, Sample V, Akano H, Magari M, Ueno T, Gorshkov K, Chen M, Tokumitsu H, Zhang J, Inoue T. Compartmentalized AMPK signaling illuminated by genetically encoded molecular sensors and actuators. Cell Reports. 11: 657-70. PMID 25892241 DOI: 10.1016/J.Celrep.2015.03.057  0.607
2015 Sample V, Ramamurthy S, Gorshkov K, Ronnett GV, Zhang J. Polarized activities of AMPK and BRSK in primary hippocampal neurons. Molecular Biology of the Cell. 26: 1935-46. PMID 25788287 DOI: 10.1091/Mbc.E14-02-0764  0.579
2015 Mehta S, Zhang J. Dynamic visualization of calcium-dependent signaling in cellular microdomains. Cell Calcium. PMID 25703691 DOI: 10.1016/J.Ceca.2015.01.009  0.366
2015 Ding Y, Li J, Enterina JR, Shen Y, Zhang I, Tewson PH, Mo GC, Zhang J, Quinn AM, Hughes TE, Maysinger D, Alford SC, Zhang Y, Campbell RE. Ratiometric biosensors based on dimerization-dependent fluorescent protein exchange. Nature Methods. 12: 195-8. PMID 25622108 DOI: 10.1038/Nmeth.3261  0.345
2015 Dou H, Wang C, Wu X, Yao L, Zhang X, Teng S, Xu H, Liu B, Wu Q, Zhang Q, Hu M, Wang Y, Wang L, Wu Y, Shang S, ... ... Zhang J, et al. Calcium influx activates adenylyl cyclase 8 for sustained insulin secretion in rat pancreatic beta cells. Diabetologia. 58: 324-33. PMID 25381556 DOI: 10.1007/S00125-014-3437-Z  0.309
2015 Zhang J. Compartmentalized PI3K/Akt/mTOR Signaling in Living Cells The Faseb Journal. 29. DOI: 10.1096/Fasebj.29.1_Supplement.234.3  0.37
2015 Hertel F, Mo G, Duwé S, Dedecker P, Zhang J. Refsofi for Imaging Protein-Protein Interactions in Living Cells in Super-Resolution Biophysical Journal. 108: 360. DOI: 10.1016/J.Bpj.2014.11.1977  0.336
2015 Mo GCH, Zhang J. A Novel Molecular Ruler between Fluorescent Proteins Biophysical Journal. 108. DOI: 10.1016/J.Bpj.2014.11.1895  0.384
2014 Gorshkov K, Zhang J. Visualization of cyclic nucleotide dynamics in neurons. Frontiers in Cellular Neuroscience. 8: 395. PMID 25538560 DOI: 10.3389/Fncel.2014.00395  0.592
2014 Newman RH, Zhang J, Zhu H. Toward a systems-level view of dynamic phosphorylation networks. Frontiers in Genetics. 5: 263. PMID 25177341 DOI: 10.3389/Fgene.2014.00263  0.383
2014 Mehta S, Aye-Han NN, Ganesan A, Oldach L, Gorshkov K, Zhang J. Calmodulin-controlled spatial decoding of oscillatory Ca2+ signals by calcineurin. Elife. 3: e03765. PMID 25056880 DOI: 10.7554/Elife.03765  0.6
2014 Kim TJ, Sun J, Lu S, Zhang J, Wang Y. The regulation of β-adrenergic receptor-mediated PKA activation by substrate stiffness via microtubule dynamics in human MSCs. Biomaterials. 35: 8348-56. PMID 24973298 DOI: 10.1016/J.Biomaterials.2014.06.018  0.332
2014 Fu Q, Kim S, Soto D, De Arcangelis V, DiPilato L, Liu S, Xu B, Shi Q, Zhang J, Xiang YK. A long lasting β1 adrenergic receptor stimulation of cAMP/protein kinase A (PKA) signal in cardiac myocytes. The Journal of Biological Chemistry. 289: 14771-81. PMID 24713698 DOI: 10.1074/Jbc.M113.542589  0.352
2014 Sample V, Mehta S, Zhang J. Genetically encoded molecular probes to visualize and perturb signaling dynamics in living biological systems. Journal of Cell Science. 127: 1151-60. PMID 24634506 DOI: 10.1242/Jcs.099994  0.352
2014 Haj Slimane Z, Bedioune I, Lechêne P, Varin A, Lefebvre F, Mateo P, Domergue-Dupont V, Dewenter M, Richter W, Conti M, El-Armouche A, Zhang J, Fischmeister R, Vandecasteele G. Control of cytoplasmic and nuclear protein kinase A by phosphodiesterases and phosphatases in cardiac myocytes. Cardiovascular Research. 102: 97-106. PMID 24550350 DOI: 10.1093/Cvr/Cvu029  0.331
2014 Hu J, Rho HS, Newman RH, Zhang J, Zhu H, Qian J. PhosphoNetworks: a database for human phosphorylation networks. Bioinformatics (Oxford, England). 30: 141-2. PMID 24227675 DOI: 10.1093/Bioinformatics/Btt627  0.31
2014 Cazabat L, Ragazzon B, Varin A, Potier-Cartereau M, Vandier C, Vezzosi D, Risk-Rabin M, Guellich A, Schittl J, Lechêne P, Richter W, Nikolaev VO, Zhang J, Bertherat J, Vandecasteele G. Inactivation of the Carney complex gene 1 (PRKAR1A) alters spatiotemporal regulation of cAMP and cAMP-dependent protein kinase: a study using genetically encoded FRET-based reporters. Human Molecular Genetics. 23: 1163-74. PMID 24122441 DOI: 10.1093/Hmg/Ddt510  0.365
2014 Aye-Han NN, Zhang J. A multiparameter live cell imaging approach to monitor cyclic AMP and protein kinase A dynamics in parallel. Methods in Molecular Biology (Clifton, N.J.). 1071: 207-15. PMID 24052391 DOI: 10.1007/978-1-62703-622-1_16  0.376
2014 Mehta S, Zhang J. Using a genetically encoded FRET-based reporter to visualize calcineurin phosphatase activity in living cells. Methods in Molecular Biology (Clifton, N.J.). 1071: 139-49. PMID 24052386 DOI: 10.1007/978-1-62703-622-1_11  0.371
2014 Newman RH, Zhang J. The design and application of genetically encodable biosensors based on fluorescent proteins. Methods in Molecular Biology (Clifton, N.J.). 1071: 1-16. PMID 24052376 DOI: 10.1007/978-1-62703-622-1_1  0.322
2014 Hu J, Rho HS, Newman RH, Hwang W, Neiswinger J, Zhu H, Zhang J, Qian J. Global analysis of phosphorylation networks in humans. Biochimica Et Biophysica Acta. 1844: 224-31. PMID 23524292 DOI: 10.1016/J.Bbapap.2013.03.009  0.327
2014 Mehta S, Aye-Han N, Ganesan A, Oldach L, Gorshkov K, Zhang J. Author response: Calmodulin-controlled spatial decoding of oscillatory Ca2+ signals by calcineurin Elife. DOI: 10.7554/Elife.03765.018  0.564
2014 Mo G, Zhang J. Mute-Kars: Silent Kinase Activity Reporters Useful for Co-Imaging Biophysical Journal. 106. DOI: 10.1016/J.Bpj.2013.11.4443  0.347
2014 Ross BL, Zhang J. Superresolution Plasmalemmal Lipid Mapping Biophysical Journal. 106. DOI: 10.1016/J.Bpj.2013.11.1756  0.31
2014 Zhang J. Probing Spatiotemporal Regulation of Signal Transduction in Living Cells Biophysical Journal. 106. DOI: 10.1016/J.Bpj.2013.11.080  0.416
2014 Hertel F, Zhang J. Monitoring of post-translational modification dynamics with genetically encoded fluorescent reporters Biopolymers. 101: 180-187. DOI: 10.1002/Bip.22254  0.343
2013 Woodard CL, Goodwin CR, Wan J, Xia S, Newman R, Hu J, Zhang J, Hayward SD, Qian J, Laterra J, Zhu H. Profiling the dynamics of a human phosphorylome reveals new components in HGF/c-Met signaling. Plos One. 8: e72671. PMID 24023761 DOI: 10.1371/Journal.Pone.0072671  0.373
2013 Nunes AR, Holmes AP, Sample V, Kumar P, Cann MJ, Monteiro EC, Zhang J, Gauda EB. Bicarbonate-sensitive soluble and transmembrane adenylyl cyclases in peripheral chemoreceptors. Respiratory Physiology & Neurobiology. 188: 83-93. PMID 23727159 DOI: 10.1016/J.Resp.2013.05.013  0.314
2013 Huang J, Yang JR, Zhang J, Yang J. Total synthesis and structure-activity relationship study of the potent cAMP signaling agonist (-)-alotaketal A. Organic & Biomolecular Chemistry. 11: 3212-22. PMID 23584129 DOI: 10.1039/C3Ob40120K  0.368
2013 Depry C, Mehta S, Zhang J. Multiplexed visualization of dynamic signaling networks using genetically encoded fluorescent protein-based biosensors Pflugers Archiv European Journal of Physiology. 465: 373-381. PMID 23138230 DOI: 10.1007/S00424-012-1175-Y  0.372
2013 Sample V, Ni Q, Mehta S, Inoue T, Zhang J. Controlling enzymatic action in living cells with a kinase-inducible bimolecular switch Acs Chemical Biology. 8: 116-121. PMID 23072367 DOI: 10.1021/Cb300393W  0.379
2013 Sample V, DiPilato LM, Yang JH, Ni Q, Saucerman JJ, Zhang J. Erratum: Corrigendum: Regulation of nuclear PKA revealed by spatiotemporal manipulation of cyclic AMP Nature Chemical Biology. 9: 406-406. DOI: 10.1038/Nchembio0613-406B  0.314
2012 Nunes AR, Sample V, Xiang YK, Monteiro EC, Gauda E, Zhang J. Effect of oxygen on phosphodiesterases (PDE) 3 and 4 isoforms and PKA activity in the superior cervical ganglia Advances in Experimental Medicine and Biology. 758: 287-294. PMID 23080174 DOI: 10.1007/978-94-007-4584-1_39  0.369
2012 Ghigo A, Perino A, Mehel H, Zahradníková A, Morello F, Leroy J, Nikolaev VO, Damilano F, Cimino J, De Luca E, Richter W, Westenbroek R, Catterall WA, Zhang J, Yan C, et al. Phosphoinositide 3-kinase γ protects against catecholamine-induced ventricular arrhythmia through protein kinase A-mediated regulation of distinct phosphodiesterases. Circulation. 126: 2073-83. PMID 23008439 DOI: 10.1161/Circulationaha.112.114074  0.375
2012 Huang J, Yang JR, Zhang J, Yang J. Total synthesis of the potent cAMP signaling agonist (-)-alotaketal A. Journal of the American Chemical Society. 134: 8806-9. PMID 22563931 DOI: 10.1021/Ja303529Z  0.319
2012 Ferrando IM, Chaerkady R, Zhong J, Molina H, Jacob HK, Herbst-Robinson K, Dancy BM, Katju V, Bose R, Zhang J, Pandey A, Cole PA. Identification of targets of c-Src tyrosine kinase by chemical complementation and phosphoproteomics. Molecular & Cellular Proteomics : McP. 11: 355-69. PMID 22499769 DOI: 10.1074/Mcp.M111.015750  0.362
2012 Sample V, DiPilato LM, Yang JH, Ni Q, Saucerman JJ, Zhang J. Regulation of nuclear PKA revealed by spatiotemporal manipulation of cyclic AMP. Nature Chemical Biology. 8: 375-82. PMID 22366721 DOI: 10.1038/Nchembio.799  0.422
2012 Aye-Han NN, Allen MD, Ni Q, Zhang J. Parallel tracking of cAMP and PKA signaling dynamics in living cells with FRET-based fluorescent biosensors. Molecular Biosystems. 8: 1435-40. PMID 22362165 DOI: 10.1039/C2Mb05514G  0.399
2012 Zhou X, Herbst-Robinson KJ, Zhang J. Visualizing dynamic activities of signaling enzymes using genetically encodable FRET-based biosensors: From designs to applications Methods in Enzymology. 504: 317-340. PMID 22264542 DOI: 10.1016/B978-0-12-391857-4.00016-1  0.409
2012 del Puerto A, Díaz-Hernández JI, Tapia M, Gomez-Villafuertes R, Benitez MJ, Zhang J, Miras-Portugal MT, Wandosell F, Díaz-Hernández M, Garrido JJ. Adenylate cyclase 5 coordinates the action of ADP, P2Y1, P2Y13 and ATP-gated P2X7 receptors on axonal elongation. Journal of Cell Science. 125: 176-88. PMID 22250198 DOI: 10.1242/Jcs.091736  0.304
2012 Slimane ZH, Zhang J, Richter W, Fischmeister R, Vandecasteele G. Spatiotemporal Regulation of cAMP-Dependent Protein Kinase (PKA) in Cardiac Myocytes Biophysical Journal. 102. DOI: 10.1016/J.Bpj.2011.11.3637  0.316
2012 Ganesan A, Levchenko A, Zhang J. ERK-Mediated Decoding of Calcium Oscillations in Pancreatic Beta Cells Biophysical Journal. 102. DOI: 10.1016/J.Bpj.2011.11.2777  0.322
2011 Chakir K, Depry C, Dimaano VL, Zhu WZ, Vanderheyden M, Bartunek J, Abraham TP, Tomaselli GF, Liu SB, Xiang YK, Zhang M, Takimoto E, Dulin N, Xiao RP, Zhang J, et al. Galphas-biased beta2-adrenergic receptor signaling from restoring synchronous contraction in the failing heart. Science Translational Medicine. 3: 100ra88. PMID 21918105 DOI: 10.1126/Scitranslmed.3001909  0.316
2011 Depry C, Zhang J. Using FRET-based reporters to visualize subcellular dynamics of protein kinase A activity Methods in Molecular Biology. 756: 285-294. PMID 21870233 DOI: 10.1007/978-1-61779-160-4_16  0.389
2011 Herbst KJ, Allen MD, Zhang J. Spatiotemporally regulated protein kinase a activity is a critical regulator of growth factor-stimulated extracellular signal-regulated kinase signaling in PC12 Cells Molecular and Cellular Biology. 31: 4063-4075. PMID 21807900 DOI: 10.1128/Mcb.05459-11  0.414
2011 Mehta S, Zhang J. Reporting from the field: Genetically encoded fluorescent reporters uncover signaling dynamics in living biological systems Annual Review of Biochemistry. 80: 375-401. PMID 21495849 DOI: 10.1146/Annurev-Biochem-060409-093259  0.334
2011 Liu S, Zhang J, Xiang YK. FRET-based direct detection of dynamic protein kinase A activity on the sarcoplasmic reticulum in cardiomyocytes Biochemical and Biophysical Research Communications. 404: 581-586. PMID 21130738 DOI: 10.1016/J.Bbrc.2010.11.116  0.391
2011 Ni Q, Ganesan A, Aye-Han NN, Gao X, Allen MD, Levchenko A, Zhang J. Signaling diversity of PKA achieved via a Ca2+-cAMP-PKA oscillatory circuit. Nature Chemical Biology. 7: 34-40. PMID 21102470 DOI: 10.1038/Nchembio.478  0.409
2011 Ganesan A, Ni Q, Aye-Han N, Gao X, Allen MD, Levchenko A, Zhang J. PKA is a Control Node in a Calcium-Dependent Oscillatory Circuit in Pancreatic Beta Cells Biophysical Journal. 100. DOI: 10.1016/J.Bpj.2010.12.3023  0.357
2009 Aye-Han NN, Ni Q, Zhang J. Fluorescent biosensors for real-time tracking of post-translational modification dynamics Current Opinion in Chemical Biology. 13: 392-397. PMID 19682946 DOI: 10.1016/J.Cbpa.2009.07.009  0.303
2009 Soto D, De Arcangelis V, Zhang J, Xiang Y. Dynamic protein kinase a activities induced by beta-adrenoceptors dictate signaling propagation for substrate phosphorylation and myocyte contraction. Circulation Research. 104: 770-9. PMID 19213958 DOI: 10.1161/Circresaha.108.187880  0.369
2009 Seong J, Lu S, Ouyang M, Huang H, Zhang J, Frame MC, Wang Y. Visualization of Src activity at different compartments of the plasma membrane by FRET imaging. Chemistry & Biology. 16: 48-57. PMID 19171305 DOI: 10.1016/J.Chembiol.2008.11.007  0.324
2008 Ananthanarayanan B, Ni Q, Zhang J. Chapter 2: Molecular sensors based on fluorescence resonance energy transfer to visualize cellular dynamics. Methods in Cell Biology. 89: 37-57. PMID 19118671 DOI: 10.1016/S0091-679X(08)00602-X  0.329
2008 Vincent P, Gervasi N, Zhang J. Real-time monitoring of cyclic nucleotide signaling in neurons using genetically encoded FRET probes. Brain Cell Biology. 36: 3-17. PMID 18941898 DOI: 10.1007/S11068-008-9035-6  0.389
2008 Allen MD, DiPilato LM, Ananthanarayanan B, Newman RH, Ni Q, Zhang J. Dynamic visualization of signaling activities in living cells. Science Signaling. 1: pt6. PMID 18799423 DOI: 10.1126/Scisignal.137Pt6  0.312
2008 Allen MD, DiPilato LM, Ananthanarayanan B, Newman RH, Ni Q, Zhang J. Dynamic visualization of signaling activities in living cells. Science Signaling. 1: pt6. PMID 18799423 DOI: 10.1126/Scisignal.137Pt6  0.312
2008 Allen MD, DiPilato LM, Ananthanarayanan B, Newman RH, Ni Q, Zhang J. Dynamic visualization of signaling activities in living cells. Science Signaling. 1: pt6. PMID 18799423 DOI: 10.1126/Scisignal.137Pt6  0.312
2008 Allen MD, DiPilato LM, Ananthanarayanan B, Newman RH, Ni Q, Zhang J. Dynamic visualization of signaling activities in living cells. Science Signaling. 1: pt6. PMID 18799423 DOI: 10.1126/Scisignal.137Pt6  0.312
2008 Allen MD, DiPilato LM, Ananthanarayanan B, Newman RH, Ni Q, Zhang J. Dynamic visualization of signaling activities in living cells. Science Signaling. 1: pt6. PMID 18799423 DOI: 10.1126/Scisignal.137Pt6  0.312
2008 Szewczuk LM, Tarrant MK, Sample V, Drury WJ, Zhang J, Cole PA. Analysis of serotonin N-acetyltransferase regulation in vitro and in live cells using protein semisynthesis. Biochemistry. 47: 10407-19. PMID 18771288 DOI: 10.1021/Bi801189D  0.363
2008 Lu S, Ouyang M, Seong J, Zhang J, Chien S, Wang Y. The spatiotemporal pattern of Src activation at lipid rafts revealed by diffusion-corrected FRET imaging. Plos Computational Biology. 4: e1000127. PMID 18711637 DOI: 10.1371/Journal.Pcbi.1000127  0.325
2008 Gao X, Zhang J. Spatiotemporal analysis of differential Akt regulation in plasma membrane microdomains Molecular Biology of the Cell. 19: 4366-4373. PMID 18701703 DOI: 10.1091/Mbc.E08-05-0449  0.386
2008 Newman RH, Zhang J. Visualization of phosphatase activity in living cells with a FRET-based calcineurin activity sensor Molecular Biosystems. 4: 496-501. PMID 18493642 DOI: 10.1039/B720034J  0.318
2008 Newman RH, Zhang J. Visualization of phosphatase activity in living cells with a FRET-based calcineurin activity sensor Molecular Biosystems. 4: 496-501. PMID 18493642 DOI: 10.1039/B720034J  0.318
2008 Newman RH, Zhang J. Visualization of phosphatase activity in living cells with a FRET-based calcineurin activity sensor Molecular Biosystems. 4: 496-501. PMID 18493642 DOI: 10.1039/B720034J  0.318
2008 Violin JD, DiPilato LM, Yildirim N, Elston TC, Zhang J, Lefkowitz RJ. beta2-adrenergic receptor signaling and desensitization elucidated by quantitative modeling of real time cAMP dynamics. The Journal of Biological Chemistry. 283: 2949-61. PMID 18045878 DOI: 10.1074/Jbc.M707009200  0.338
2008 Ni Q, Fosbrink M, Zhang J. Illuminating the phosphatidylinositol 3-kinase/Akt pathway Progress in Biomedical Optics and Imaging - Proceedings of Spie. 6868. DOI: 10.1117/12.765524  0.405
2007 Ananthanarayanan B, Fosbrink M, Rahdar M, Zhang J. Live-cell molecular analysis of Akt activation reveals roles for activation loop phosphorylation. The Journal of Biological Chemistry. 282: 36634-41. PMID 17928291 DOI: 10.1074/Jbc.M706227200  0.35
2007 Gervasi N, Hepp R, Tricoire L, Zhang J, Lambolez B, Paupardin-Tritsch D, Vincent P. Dynamics of protein kinase A signaling at the membrane, in the cytosol, and in the nucleus of neurons in mouse brain slices. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 2744-50. PMID 17360896 DOI: 10.1523/Jneurosci.5352-06.2007  0.359
2006 Allen MD, DiPilato LM, Rahdar M, Ren YR, Chong C, Liu JO, Zhang J. Reading dynamic kinase activity in living cells for high-throughput screening. Acs Chemical Biology. 1: 371-6. PMID 17163774 DOI: 10.1021/Cb600202F  0.37
2006 Dunn TA, Wang CT, Colicos MA, Zaccolo M, DiPilato LM, Zhang J, Tsien RY, Feller MB. Imaging of cAMP levels and protein kinase A activity reveals that retinal waves drive oscillations in second-messenger cascades. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 12807-15. PMID 17151284 DOI: 10.1523/Jneurosci.3238-06.2006  0.37
2006 Saucerman JJ, Zhang J, Martin JC, Peng LX, Stenbit AE, Tsien RY, McCulloch AD. Systems analysis of PKA-mediated phosphorylation gradients in live cardiac myocytes. Proceedings of the National Academy of Sciences of the United States of America. 103: 12923-8. PMID 16905651 DOI: 10.1073/Pnas.0600137103  0.379
2006 Allen MD, Zhang J. Subcellular dynamics of protein kinase A activity visualized by FRET-based reporters. Biochemical and Biophysical Research Communications. 348: 716-21. PMID 16895723 DOI: 10.1016/J.Bbrc.2006.07.136  0.301
2006 Allen MD, Zhang J. Subcellular dynamics of protein kinase A activity visualized by FRET-based reporters. Biochemical and Biophysical Research Communications. 348: 716-21. PMID 16895723 DOI: 10.1016/J.Bbrc.2006.07.136  0.301
2006 Allen MD, Zhang J. Subcellular dynamics of protein kinase A activity visualized by FRET-based reporters. Biochemical and Biophysical Research Communications. 348: 716-21. PMID 16895723 DOI: 10.1016/J.Bbrc.2006.07.136  0.301
2006 Allen MD, Zhang J. Subcellular dynamics of protein kinase A activity visualized by FRET-based reporters. Biochemical and Biophysical Research Communications. 348: 716-21. PMID 16895723 DOI: 10.1016/J.Bbrc.2006.07.136  0.301
2005 Zhang J, Hupfeld CJ, Taylor SS, Olefsky JM, Tsien RY. Insulin disrupts beta-adrenergic signalling to protein kinase A in adipocytes. Nature. 437: 569-73. PMID 16177793 DOI: 10.1038/Nature04140  0.345
2005 Kunkel MT, Ni Q, Tsien RY, Zhang J, Newton AC. Spatio-temporal dynamics of protein kinase B/Akt signaling revealed by a genetically encoded fluorescent reporter. The Journal of Biological Chemistry. 280: 5581-7. PMID 15583002 DOI: 10.1074/Jbc.M411534200  0.432
2004 DiPilato LM, Cheng X, Zhang J. Fluorescent indicators of cAMP and Epac activation reveal differential dynamics of cAMP signaling within discrete subcellular compartments. Proceedings of the National Academy of Sciences of the United States of America. 101: 16513-8. PMID 15545605 DOI: 10.1073/Pnas.0405973101  0.321
2004 DiPilato LM, Cheng X, Zhang J. Fluorescent indicators of cAMP and Epac activation reveal differential dynamics of cAMP signaling within discrete subcellular compartments. Proceedings of the National Academy of Sciences of the United States of America. 101: 16513-8. PMID 15545605 DOI: 10.1073/Pnas.0405973101  0.321
2004 DiPilato LM, Cheng X, Zhang J. Fluorescent indicators of cAMP and Epac activation reveal differential dynamics of cAMP signaling within discrete subcellular compartments. Proceedings of the National Academy of Sciences of the United States of America. 101: 16513-8. PMID 15545605 DOI: 10.1073/Pnas.0405973101  0.321
2004 DiPilato LM, Cheng X, Zhang J. Fluorescent indicators of cAMP and Epac activation reveal differential dynamics of cAMP signaling within discrete subcellular compartments. Proceedings of the National Academy of Sciences of the United States of America. 101: 16513-8. PMID 15545605 DOI: 10.1073/Pnas.0405973101  0.321
2004 DiPilato LM, Cheng X, Zhang J. Fluorescent indicators of cAMP and Epac activation reveal differential dynamics of cAMP signaling within discrete subcellular compartments. Proceedings of the National Academy of Sciences of the United States of America. 101: 16513-8. PMID 15545605 DOI: 10.1073/Pnas.0405973101  0.321
2004 DiPilato LM, Cheng X, Zhang J. Fluorescent indicators of cAMP and Epac activation reveal differential dynamics of cAMP signaling within discrete subcellular compartments. Proceedings of the National Academy of Sciences of the United States of America. 101: 16513-8. PMID 15545605 DOI: 10.1073/Pnas.0405973101  0.321
2004 DiPilato LM, Cheng X, Zhang J. Fluorescent indicators of cAMP and Epac activation reveal differential dynamics of cAMP signaling within discrete subcellular compartments. Proceedings of the National Academy of Sciences of the United States of America. 101: 16513-8. PMID 15545605 DOI: 10.1073/Pnas.0405973101  0.321
2004 DiPilato LM, Cheng X, Zhang J. Fluorescent indicators of cAMP and Epac activation reveal differential dynamics of cAMP signaling within discrete subcellular compartments. Proceedings of the National Academy of Sciences of the United States of America. 101: 16513-8. PMID 15545605 DOI: 10.1073/Pnas.0405973101  0.321
2004 DiPilato LM, Cheng X, Zhang J. Fluorescent indicators of cAMP and Epac activation reveal differential dynamics of cAMP signaling within discrete subcellular compartments. Proceedings of the National Academy of Sciences of the United States of America. 101: 16513-8. PMID 15545605 DOI: 10.1073/Pnas.0405973101  0.321
2002 Zhang J, Campbell RE, Ting AY, Tsien RY. Creating new fluorescent probes for cell biology. Nature Reviews. Molecular Cell Biology. 3: 906-18. PMID 12461557 DOI: 10.1038/Nrm976  0.347
2001 Zhang J, Ma Y, Taylor SS, Tsien RY. Genetically encoded reporters of protein kinase A activity reveal impact of substrate tethering. Proceedings of the National Academy of Sciences of the United States of America. 98: 14997-5002. PMID 11752448 DOI: 10.1073/Pnas.211566798  0.379
2000 Campbell AM, Tok JB, Zhang J, Wang Y, Stein M, Lynn DG, Binns AN. Xenognosin sensing in virulence: is there a phenol receptor in Agrobacterium tumefaciens? Chemistry & Biology. 7: 65-76. PMID 10662683 DOI: 10.1016/S1074-5521(00)00065-X  0.312
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