Ryan Jefferson Watts - Publications

Affiliations: 
Genentech, Inc., San Francisco, CA, United States 
Area:
Neurodegeneration, Blood-brian barrier

43 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Xiong M, Jiang H, Serrano JR, Gonzales ER, Wang C, Gratuze M, Hoyle R, Bien-Ly N, Silverman AP, Sullivan PM, Watts RJ, Ulrich JD, Zipfel GJ, Holtzman DM. APOE immunotherapy reduces cerebral amyloid angiopathy and amyloid plaques while improving cerebrovascular function. Science Translational Medicine. 13. PMID 33597265 DOI: 10.1126/scitranslmed.abd7522  0.504
2020 Kariolis MS, Wells RC, Getz JA, Kwan W, Mahon CS, Tong R, Kim DJ, Srivastava A, Bedard C, Henne KR, Giese T, Assimon VA, Chen X, Zhang Y, Solanoy H, ... ... Watts RJ, et al. Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys. Science Translational Medicine. 12. PMID 32461332 DOI: 10.1126/Scitranslmed.Aay1359  0.351
2020 Ullman JC, Arguello A, Getz JA, Bhalla A, Mahon CS, Wang J, Giese T, Bedard C, Kim DJ, Blumenfeld JR, Liang N, Ravi R, Nugent AA, Davis SS, Ha C, ... ... Watts RJ, et al. Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice. Science Translational Medicine. 12. PMID 32461331 DOI: 10.1126/Scitranslmed.Aay1163  0.341
2019 Nugent AA, Lin K, van Lengerich B, Lianoglou S, Przybyla L, Davis SS, Llapashtica C, Wang J, Kim DJ, Xia D, Lucas A, Baskaran S, Haddick PCG, Lenser M, Earr TK, ... ... Watts RJ, et al. TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge. Neuron. PMID 31902528 DOI: 10.1016/J.Neuron.2019.12.007  0.331
2019 Henry AG, Kariolis MS, Ullman JC, Getz JA, Arguello A, Mahon C, Wang J, Bhalla A, Giese T, Bedard C, Kim DJ, Blumenfeld J, Liang N, Duque J, Tran H, ... ... Watts RJ, et al. Improved brain uptake and efficacy of iduronate 2-sulfatase with the enzyme transport vehicle Molecular Genetics and Metabolism. 126: S72. DOI: 10.1016/J.Ymgme.2018.12.174  0.301
2018 Liao F, Li A, Xiong M, Bien-Ly N, Jiang H, Zhang Y, Finn MB, Hoyle R, Keyser J, Lefton KB, Robinson GO, Serrano JR, Silverman AP, Guo JL, Getz J, ... ... Watts RJ, et al. Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation. The Journal of Clinical Investigation. PMID 29600961 DOI: 10.1172/Jci96429  0.556
2017 Bumbaca Yadav D, Maloney JA, Wildsmith KR, Fuji RN, Meilandt WJ, Solanoy H, Lu Y, Peng K, Wilson B, Chan P, Gadkar K, Kosky A, Goo M, Daugherty A, Couch JA, ... ... Watts RJ, et al. Widespread brain distribution and activity following anti-BACE1 intracerebroventricular infusion in nonhuman primates. British Journal of Pharmacology. PMID 28859225 DOI: 10.1111/Bph.14021  0.314
2017 Lo M, Kim HS, Tong RK, Bainbridge TW, Vernes JM, Zhang Y, Lin YL, Chung S, Dennis MS, Zuchero YJ, Watts RJ, Couch JA, Meng YG, Atwal JK, Brezski RJ, et al. Effector attenuating substitutions that maintain antibody stability and reduce toxicity in mice. The Journal of Biological Chemistry. PMID 28077575 DOI: 10.1074/Jbc.M116.767749  0.306
2016 Lee SH, Le Pichon CE, Adolfsson O, Gafner V, Pihlgren M, Lin H, Solanoy H, Brendza R, Ngu H, Foreman O, Chan R, Ernst JA, DiCara D, Hotzel I, Srinivasan K, ... ... Watts RJ, et al. Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement. Cell Reports. PMID 27475227 DOI: 10.1016/J.Celrep.2016.06.099  0.347
2016 Gadkar K, Yadav DB, Zuchero JY, Couch JA, Kanodia J, Kenrick MK, Atwal JK, Dennis MS, Prabhu S, Watts RJ, Joseph SB, Ramanujan S. Mathematical PKPD and safety model of bispecific TfR/BACE1 antibodies for the optimization of antibody uptake in brain. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V. PMID 26820920 DOI: 10.1016/J.Ejpb.2016.01.009  0.351
2015 Zuchero YJ, Chen X, Bien-Ly N, Bumbaca D, Tong RK, Gao X, Zhang S, Hoyte K, Luk W, Huntley MA, Phu L, Tan C, Kallop D, Weimer RM, Lu Y, ... ... Watts RJ, et al. Discovery of Novel Blood-Brain Barrier Targets to Enhance Brain Uptake of Therapeutic Antibodies. Neuron. PMID 26687840 DOI: 10.1016/J.Neuron.2015.11.024  0.568
2015 Bien-Ly N, Boswell CA, Jeet S, Beach TG, Hoyte K, Luk W, Shihadeh V, Ulufatu S, Foreman O, Lu Y, DeVoss J, van der Brug M, Watts RJ. Lack of Widespread BBB Disruption in Alzheimer's Disease Models: Focus on Therapeutic Antibodies. Neuron. 88: 289-97. PMID 26494278 DOI: 10.1016/J.Neuron.2015.09.036  0.563
2014 Wetzel-Smith MK, Hunkapiller J, Bhangale TR, Srinivasan K, Maloney JA, Atwal JK, Sa SM, Yaylaoglu MB, Foreman O, Ortmann W, Rathore N, Hansen DV, Tessier-Lavigne M, Mayeux R, ... ... Watts RJ, et al. A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death. Nature Medicine. 20: 1452-7. PMID 25419706 DOI: 10.1038/Nm.3736  0.322
2014 Huntley MA, Bien-Ly N, Daneman R, Watts RJ. Dissecting gene expression at the blood-brain barrier. Frontiers in Neuroscience. 8: 355. PMID 25414634 DOI: 10.3389/Fnins.2014.00355  0.541
2014 Bien-Ly N, Watts RJ. The blood-brain barrier's gut check. Science Translational Medicine. 6: 263fs46. PMID 25411469 DOI: 10.1126/Scitranslmed.Aaa2543  0.518
2014 Yu YJ, Atwal JK, Zhang Y, Tong RK, Wildsmith KR, Tan C, Bien-Ly N, Hersom M, Maloney JA, Meilandt WJ, Bumbaca D, Gadkar K, Hoyte K, Luk W, Lu Y, ... ... Watts RJ, et al. Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates. Science Translational Medicine. 6: 261ra154. PMID 25378646 DOI: 10.1126/Scitranslmed.3009835  0.566
2014 Bien-Ly N, Yu YJ, Bumbaca D, Elstrott J, Boswell CA, Zhang Y, Luk W, Lu Y, Dennis MS, Weimer RM, Chung I, Watts RJ. Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants. The Journal of Experimental Medicine. 211: 233-44. PMID 24470444 DOI: 10.1084/Jem.20131660  0.566
2013 Couch JA, Yu YJ, Zhang Y, Tarrant JM, Fuji RN, Meilandt WJ, Solanoy H, Tong RK, Hoyte K, Luk W, Lu Y, Gadkar K, Prabhu S, Ordonia BA, Nguyen Q, ... ... Watts RJ, et al. Addressing safety liabilities of TfR bispecific antibodies that cross the blood-brain barrier. Science Translational Medicine. 5: 183ra57, 1-12. PMID 23636093 DOI: 10.1126/Scitranslmed.3005338  0.341
2013 Watts RJ, Dennis MS. Bispecific antibodies for delivery into the brain. Current Opinion in Chemical Biology. 17: 393-9. PMID 23570979 DOI: 10.1016/J.Cbpa.2013.03.023  0.335
2013 Yu YJ, Watts RJ. Developing therapeutic antibodies for neurodegenerative disease. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 10: 459-72. PMID 23549647 DOI: 10.1007/S13311-013-0187-4  0.35
2013 Hunt KW, Cook AW, Watts RJ, Clark CT, Vigers G, Smith D, Metcalf AT, Gunawardana IW, Burkard M, Cox AA, Geck Do MK, Dutcher D, Thomas AA, Rana S, Kallan NC, et al. Spirocyclic β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors: from hit to lowering of cerebrospinal fluid (CSF) amyloid β in a higher species. Journal of Medicinal Chemistry. 56: 3379-403. PMID 23537249 DOI: 10.1021/Jm4002154  0.322
2012 Chen M, Maloney JA, Kallop DY, Atwal JK, Tam SJ, Baer K, Kissel H, Kaminker JS, Lewcock JW, Weimer RM, Watts RJ. Spatially coordinated kinase signaling regulates local axon degeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 13439-53. PMID 23015435 DOI: 10.1523/Jneurosci.2039-12.2012  0.6
2012 Adolfsson O, Pihlgren M, Toni N, Varisco Y, Buccarello AL, Antoniello K, Lohmann S, Piorkowska K, Gafner V, Atwal JK, Maloney J, Chen M, Gogineni A, Weimer RM, Mortensen DL, ... ... Watts RJ, et al. An effector-reduced anti-β-amyloid (Aβ) antibody with unique aβ binding properties promotes neuroprotection and glial engulfment of Aβ. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 9677-89. PMID 22787053 DOI: 10.1523/Jneurosci.4742-11.2012  0.337
2012 Tam SJ, Richmond DL, Kaminker JS, Modrusan Z, Martin-McNulty B, Cao TC, Weimer RM, Carano RA, van Bruggen N, Watts RJ. Death receptors DR6 and TROY regulate brain vascular development. Developmental Cell. 22: 403-17. PMID 22340501 DOI: 10.1016/J.Devcel.2011.11.018  0.52
2012 Dennis MS, Watts RJ. Transferrin antibodies into the brain. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 302-3. PMID 22157868 DOI: 10.1038/Npp.2011.196  0.349
2012 Atwal J, Yu J, Zhang Y, Chen Y, Chiu C, Meilandt W, Scearce-Levie K, Lu Y, Kenrick M, Prabhu S, Wu Y, Dennis M, Watts R. Enhancing antibody uptake in brain to target BACE1 Alzheimers & Dementia. 8: 95. DOI: 10.1016/J.Jalz.2012.05.234  0.318
2011 Ghosh AS, Wang B, Pozniak CD, Chen M, Watts RJ, Lewcock JW. DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity. The Journal of Cell Biology. 194: 751-64. PMID 21893599 DOI: 10.1083/Jcb.201103153  0.398
2011 Yu YJ, Zhang Y, Kenrick M, Hoyte K, Luk W, Lu Y, Atwal J, Elliott JM, Prabhu S, Watts RJ, Dennis MS. Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target. Science Translational Medicine. 3: 84ra44. PMID 21613623 DOI: 10.1126/Scitranslmed.3002230  0.359
2011 Atwal JK, Chen Y, Chiu C, Mortensen DL, Meilandt WJ, Liu Y, Heise CE, Hoyte K, Luk W, Lu Y, Peng K, Wu P, Rouge L, Zhang Y, Lazarus RA, ... ... Watts RJ, et al. A therapeutic antibody targeting BACE1 inhibits amyloid-β production in vivo. Science Translational Medicine. 3: 84ra43. PMID 21613622 DOI: 10.1126/Scitranslmed.3002254  0.361
2011 Neuwelt EA, Bauer B, Fahlke C, Fricker G, Iadecola C, Janigro D, Leybaert L, Molnár Z, O'Donnell ME, Povlishock JT, Saunders NR, Sharp F, Stanimirovic D, Watts RJ, Drewes LR. Engaging neuroscience to advance translational research in brain barrier biology. Nature Reviews. Neuroscience. 12: 169-82. PMID 21331083 DOI: 10.1038/Nrn2995  0.303
2011 Koch AW, Mathivet T, Larrivée B, Tong RK, Kowalski J, Pibouin-Fragner L, Bouvrée K, Stawicki S, Nicholes K, Rathore N, Scales SJ, Luis E, del Toro R, Freitas C, Bréant C, ... ... Watts RJ, et al. Robo4 maintains vessel integrity and inhibits angiogenesis by interacting with UNC5B. Developmental Cell. 20: 33-46. PMID 21238923 DOI: 10.1016/J.Devcel.2010.12.001  0.323
2010 Wu Y, Cain-Hom C, Choy L, Hagenbeek TJ, de Leon GP, Chen Y, Finkle D, Venook R, Wu X, Ridgway J, Schahin-Reed D, Dow GJ, Shelton A, Stawicki S, Watts RJ, et al. Therapeutic antibody targeting of individual Notch receptors. Nature. 464: 1052-7. PMID 20393564 DOI: 10.1038/Nature08878  0.316
2010 Tam SJ, Watts RJ. Connecting vascular and nervous system development: angiogenesis and the blood-brain barrier. Annual Review of Neuroscience. 33: 379-408. PMID 20367445 DOI: 10.1146/Annurev-Neuro-060909-152829  0.492
2009 Mortensen D, Deng R, Adolfsson O, Tam S, Peng K, Lu Y, Erickson R, Schofield C, DuPree K, Pastuskovas CV, Boswell CA, Goldman H, Bormans G, Iyer S, Khawli LA, ... ... Watts R, et al. Characterization of the pharmacokinetics, pharmacodynamics, and distribution of anti-abeta antibody MABT5102A Alzheimers & Dementia. 5: 419. DOI: 10.1016/J.Jalz.2009.04.930  0.475
2008 Hoopfer ED, Penton A, Watts RJ, Luo L. Genomic analysis of Drosophila neuronal remodeling: a role for the RNA-binding protein Boule as a negative regulator of axon pruning. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 6092-103. PMID 18550751 DOI: 10.1523/Jneurosci.0677-08.2008  0.781
2007 Liang WC, Dennis MS, Stawicki S, Chanthery Y, Pan Q, Chen Y, Eigenbrot C, Yin J, Koch AW, Wu X, Ferrara N, Bagri A, Tessier-Lavigne M, Watts RJ, Wu Y. Function blocking antibodies to neuropilin-1 generated from a designed human synthetic antibody phage library. Journal of Molecular Biology. 366: 815-29. PMID 17196977 DOI: 10.1016/J.Jmb.2006.11.021  0.326
2006 Hoopfer ED, McLaughlin T, Watts RJ, Schuldiner O, O'Leary DD, Luo L. Wlds protection distinguishes axon degeneration following injury from naturally occurring developmental pruning. Neuron. 50: 883-95. PMID 16772170 DOI: 10.1016/J.Neuron.2006.05.013  0.743
2006 MacDonald JM, Beach MG, Porpiglia E, Sheehan AE, Watts RJ, Freeman MR. The Drosophila cell corpse engulfment receptor Draper mediates glial clearance of severed axons. Neuron. 50: 869-81. PMID 16772169 DOI: 10.1016/J.Neuron.2006.04.028  0.469
2005 Marin EC, Watts RJ, Tanaka NK, Ito K, Luo L. Developmentally programmed remodeling of the Drosophila olfactory circuit. Development (Cambridge, England). 132: 725-37. PMID 15659487 DOI: 10.1242/Dev.01614  0.747
2004 Watts RJ, Schuldiner O, Perrino J, Larsen C, Luo L. Glia engulf degenerating axons during developmental axon pruning. Current Biology : Cb. 14: 678-84. PMID 15084282 DOI: 10.1016/J.Cub.2004.03.035  0.766
2003 Zhai Q, Wang J, Kim A, Liu Q, Watts R, Hoopfer E, Mitchison T, Luo L, He Z. Involvement of the ubiquitin-proteasome system in the early stages of wallerian degeneration. Neuron. 39: 217-25. PMID 12873380 DOI: 10.1016/S0896-6273(03)00429-X  0.782
2003 Watts RJ, Hoopfer ED, Luo L. Axon pruning during Drosophila metamorphosis: evidence for local degeneration and requirement of the ubiquitin-proteasome system. Neuron. 38: 871-85. PMID 12818174 DOI: 10.1016/S0896-6273(03)00295-2  0.785
2002 Jefferis GS, Marin EC, Watts RJ, Luo L. Development of neuronal connectivity in Drosophila antennal lobes and mushroom bodies. Current Opinion in Neurobiology. 12: 80-6. PMID 11861168 DOI: 10.1016/S0959-4388(02)00293-3  0.732
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