| Year |
Citation |
Score |
| 2021 |
Parker JL, Deme JC, Kuteyi G, Wu Z, Huo J, Goldman ID, Owens RJ, Biggin PC, Lea SM, Newstead S. Structural basis of antifolate recognition and transport by PCFT. Nature. PMID 34040256 DOI: 10.1038/s41586-021-03579-z |
0.347 |
|
| 2020 |
Zhan HQ, Najmi M, Lin K, Aluri S, Fiser A, Goldman ID, Zhao R. A proton-coupled folate transporter mutation causing hereditary folate malabsorption locks the protein in an inward-open conformation. The Journal of Biological Chemistry. PMID 32893190 DOI: 10.1074/Jbc.Ra120.014757 |
0.483 |
|
| 2019 |
Alam C, Aufreiter S, Georgiou CJ, Hoque MT, Finnell RH, O'Connor DL, Goldman ID, Bendayan R. Upregulation of reduced folate carrier by vitamin D enhances brain folate uptake in mice lacking folate receptor alpha. Proceedings of the National Academy of Sciences of the United States of America. PMID 31405972 DOI: 10.1073/Pnas.1907077116 |
0.389 |
|
| 2019 |
Aluri S, Zhao R, Lin K, Shin DS, Fiser A, Goldman ID. Substitutions that lock and unlock the proton-coupled folate transporter (PCFT-SLC46A1) in an inward-open conformation. The Journal of Biological Chemistry. PMID 30858177 DOI: 10.1074/Jbc.Ra118.005533 |
0.512 |
|
| 2018 |
Aluri S, Zhao R, Lubout C, Goorden SMI, Fiser A, Goldman ID. Hereditary folate malabsorption due to a mutation in the external gate of the proton-coupled folate transporter SLC46A1. Blood Advances. 2: 61-68. PMID 29344585 DOI: 10.1182/Bloodadvances.2017012690 |
0.534 |
|
| 2018 |
Zhao R, Najmi M, Aluri S, Spray DC, Goldman ID. Concentrative transport of antifolates mediated by the proton-coupled folate transporter (PCFT, SLC46A1); augmentation by a HEPES buffer. Molecular Pharmacology. PMID 29326243 DOI: 10.1124/Mol.117.110445 |
0.483 |
|
| 2017 |
Aluri S, Zhao R, Fiser A, Goldman ID. Substituted-cysteine accessibility and cross-linking identify an exofacial cleft in the 7(th) and 8(th) helices of the proton-coupled folate transporter (SLC46A1). American Journal of Physiology. Cell Physiology. ajpcell.00215.2017. PMID 29167151 DOI: 10.1152/Ajpcell.00215.2017 |
0.477 |
|
| 2017 |
Alam C, Hoque MT, Finnell RH, Goldman ID, Bendayan R. Regulation of Reduced Folate Carrier (RFC) by Vitamin D Receptor at the Blood-Brain Barrier. Molecular Pharmaceutics. PMID 28885847 DOI: 10.1021/Acs.Molpharmaceut.7B00572 |
0.422 |
|
| 2017 |
Aluri S, Zhao R, Fiser A, Goldman ID. Residues in the eighth transmembrane domain of the proton-coupled folate transporter (SLC46A1) play an important role in defining the aqueous translocation pathway and in folate substrate binding. Biochimica Et Biophysica Acta. PMID 28802835 DOI: 10.1016/J.Bbamem.2017.08.006 |
0.504 |
|
| 2017 |
Zhao R, Najmi M, Aluri S, Goldman ID. Impact of post-translational modifications of engineered cysteines on the substituted cysteine accessibility method; evidence for glutathionylation. American Journal of Physiology. Cell Physiology. ajpcell.00350.2016. PMID 28122733 DOI: 10.1152/Ajpcell.00350.2016 |
0.456 |
|
| 2016 |
Zhao R, Aluri S, Goldman ID. The proton-coupled folate transporter (PCFT-SLC46A1) and the syndrome of systemic and cerebral folate deficiency of infancy: Hereditary folate malabsorption. Molecular Aspects of Medicine. PMID 27664775 DOI: 10.1016/J.Mam.2016.09.002 |
0.462 |
|
| 2016 |
Najmi M, Zhao R, Fiser A, Goldman ID. Role of the Tryptophan Residues in Proton-Coupled Folate Transporter (PCFT-SLC46A1) Function. American Journal of Physiology. Cell Physiology. ajpcell.00084.2016. PMID 27251438 DOI: 10.1152/Ajpcell.00084.2016 |
0.518 |
|
| 2016 |
Zhao R, Najmi M, Fiser A, Goldman ID. Identification of an Extracellular Gate for the Proton-Coupled Folate Transporter (SLC46A1) by Cysteine Cross-Linking. The Journal of Biological Chemistry. PMID 26884338 DOI: 10.1074/Jbc.M115.693929 |
0.495 |
|
| 2015 |
Visentin M, Unal ES, Najmi M, Fiser A, Zhao R, Goldman ID. Identification of Tyr residues that enhance folate substrate binding and constrain oscillation of the proton-coupled folate transporter (PCFT-SLC46A1). American Journal of Physiology. Cell Physiology. 308: C631-41. PMID 25608532 DOI: 10.1152/Ajpcell.00238.2014 |
0.788 |
|
| 2014 |
Visentin M, Unal ES, Goldman ID. The impact of 5-formyltetrahydrofolate on the anti-tumor activity of pralatrexate, as compared to methotrexate, in HeLa cells in vitro Cancer Chemotherapy and Pharmacology. 73: 1055-1062. PMID 24682532 DOI: 10.1007/S00280-014-2441-9 |
0.7 |
|
| 2014 |
Visentin M, Diop-Bove N, Zhao R, Goldman ID. The intestinal absorption of folates. Annual Review of Physiology. 76: 251-74. PMID 24512081 DOI: 10.1146/Annurev-Physiol-020911-153251 |
0.48 |
|
| 2014 |
Zhao R, Diop-Bove N, Goldman ID. Enhanced receptor-mediated endocytosis and cytotoxicity of a folic acid-desacetylvinblastine monohydrazide conjugate in a pemetrexed-resistant cell line lacking folate-specific facilitative carriers but with increased folate receptor expression. Molecular Pharmacology. 85: 310-21. PMID 24249723 DOI: 10.1124/Mol.113.089110 |
0.484 |
|
| 2014 |
Visentin M, Unal ES, Goldman ID. Abstract 1784: The impact of the natural (6S) isomer of 5-formyltetrahydrofolate on the activities of pralatrexate and methotrexate in vitro Cancer Research. 74: 1784-1784. DOI: 10.1158/1538-7445.Am2014-1784 |
0.72 |
|
| 2013 |
Zhao R, Goldman ID. The proton-coupled folate transporter: physiological and pharmacological roles. Current Opinion in Pharmacology. 13: 875-80. PMID 24383099 DOI: 10.1016/J.Coph.2013.09.011 |
0.534 |
|
| 2013 |
Visentin M, Unal ES, Zhao R, Goldman ID. The membrane transport and polyglutamation of pralatrexate: A new-generation dihydrofolate reductase inhibitor Cancer Chemotherapy and Pharmacology. 72: 597-606. PMID 23881211 DOI: 10.1007/S00280-013-2231-9 |
0.746 |
|
| 2013 |
Diop-Bove N, Jain M, Scaglia F, Goldman ID. A novel deletion mutation in the proton-coupled folate transporter (PCFT; SLC46A1) in a Nicaraguan child with hereditary folate malabsorption. Gene. 527: 673-4. PMID 23816405 DOI: 10.1016/j.gene.2013.06.039 |
0.361 |
|
| 2013 |
Zhao R, Visentin M, Suadicani SO, Goldman ID. Inhibition of the proton-coupled folate transporter (PCFT-SLC46A1) by bicarbonate and other anions. Molecular Pharmacology. 84: 95-103. PMID 23609145 DOI: 10.1124/Mol.113.085605 |
0.504 |
|
| 2013 |
Shin DS, Zhao R, Fiser A, Goldman ID. Role of the fourth transmembrane domain in proton-coupled folate transporter function as assessed by the substituted cysteine accessibility method. American Journal of Physiology. Cell Physiology. 304: C1159-67. PMID 23552283 DOI: 10.1152/Ajpcell.00353.2012 |
0.536 |
|
| 2013 |
Zhao R, Goldman ID. Folate and thiamine transporters mediated by facilitative carriers (SLC19A1-3 and SLC46A1) and folate receptors. Molecular Aspects of Medicine. 34: 373-85. PMID 23506878 DOI: 10.1016/J.Mam.2012.07.006 |
0.499 |
|
| 2013 |
Mangone M, Mei AH, Scotto L, Visentin M, Marchi E, Goldman ID, Mitsiades CS, O'Connor OA, Cho HJ. Pre-Clinical Analysis Of The Novel Antifolate Pralatrexate In Multiple Myeloma Reveals Functional Biomarkers Correlated With Response Blood. 122: 4430-4430. DOI: 10.1182/Blood.V122.21.4430.4430 |
0.367 |
|
| 2013 |
Visentin M, Unal ES, Zhao R, Goldman ID. Abstract 5491: Marked augmentation of the polyglutamate derivatives as the basis for the enhanced activity of pralatrexate relative to methotrexate. Cancer Research. 73: 5491-5491. DOI: 10.1158/1538-7445.Am2013-5491 |
0.77 |
|
| 2012 |
Zhao R, Shin DS, Fiser A, Goldman ID. Identification of a functionally critical GXXG motif and its relationship to the folate binding site of the proton-coupled folate transporter (PCFT-SLC46A1). American Journal of Physiology. Cell Physiology. 303: C673-81. PMID 22785121 DOI: 10.1152/Ajpcell.00123.2012 |
0.499 |
|
| 2012 |
Visentin M, Zhao R, Goldman ID. Augmentation of reduced folate carrier-mediated folate/antifolate transport through an antiport mechanism with 5-aminoimidazole-4-carboxamide riboside monophosphate. Molecular Pharmacology. 82: 209-16. PMID 22554803 DOI: 10.1124/Mol.112.078642 |
0.534 |
|
| 2012 |
Visentin M, Chang MH, Romero MF, Zhao R, Goldman ID. Substrate- and pH-specific antifolate transport mediated by organic anion-transporting polypeptide 2B1 (OATP2B1-SLCO2B1). Molecular Pharmacology. 81: 134-42. PMID 22021325 DOI: 10.1124/Mol.111.074823 |
0.482 |
|
| 2011 |
Zhao R, Shin DS, Diop-Bove N, Ovits CG, Goldman ID. Random mutagenesis of the proton-coupled folate transporter (SLC46A1), clustering of mutations, and the bases for associated losses of function. The Journal of Biological Chemistry. 286: 24150-8. PMID 21602279 DOI: 10.1074/Jbc.M111.236539 |
0.405 |
|
| 2011 |
Zhao R, Diop-Bove N, Visentin M, Goldman ID. Mechanisms of membrane transport of folates into cells and across epithelia. Annual Review of Nutrition. 31: 177-201. PMID 21568705 DOI: 10.1146/Annurev-Nutr-072610-145133 |
0.533 |
|
| 2011 |
Mahadeo KM, Diop-Bove N, Ramirez SI, Cadilla CL, Rivera E, Martin M, Lerner NB, DiAntonio L, Duva S, Santiago-Borrero PJ, Goldman ID. Prevalence of a loss-of-function mutation in the proton-coupled folate transporter gene (PCFT-SLC46A1) causing hereditary folate malabsorption in Puerto Rico. The Journal of Pediatrics. 159: 623-7.e1. PMID 21489556 DOI: 10.1016/J.Jpeds.2011.03.005 |
0.338 |
|
| 2011 |
Shin DS, Mahadeo K, Min SH, Diop-Bove N, Clayton P, Zhao R, Goldman ID. Identification of novel mutations in the proton-coupled folate transporter (PCFT-SLC46A1) associated with hereditary folate malabsorption. Molecular Genetics and Metabolism. 103: 33-7. PMID 21333572 DOI: 10.1016/J.Ymgme.2011.01.008 |
0.427 |
|
| 2011 |
Zhao R, Shin DS, Goldman ID. Vulnerability of the cysteine-less proton-coupled folate transporter (PCFT-SLC46A1) to mutational stress associated with the substituted cysteine accessibility method. Biochimica Et Biophysica Acta. 1808: 1140-5. PMID 21256110 DOI: 10.1016/J.Bbamem.2011.01.008 |
0.517 |
|
| 2010 |
Shin DS, Min SH, Russell L, Zhao R, Fiser A, Goldman ID. Functional roles of aspartate residues of the proton-coupled folate transporter (PCFT-SLC46A1); a D156Y mutation causing hereditary folate malabsorption. Blood. 116: 5162-9. PMID 20805364 DOI: 10.1182/Blood-2010-06-291237 |
0.484 |
|
| 2010 |
Atabay B, Turker M, Ozer EA, Mahadeo K, Diop-Bove N, Goldman ID. Mutation of the proton-coupled folate transporter gene (PCFT-SLC46A1) in Turkish siblings with hereditary folate malabsorption Pediatric Hematology and Oncology. 27: 614-619. PMID 20795774 DOI: 10.3109/08880018.2010.481705 |
0.391 |
|
| 2010 |
Mahadeo K, Diop-Bove N, Shin D, Unal ES, Teo J, Zhao R, Chang MH, Fulterer A, Romero MF, Goldman ID. Properties of the Arg376 residue of the proton-coupled folate transporter (PCFT-SLC46A1) and a glutamine mutant causing hereditary folate malabsorption. American Journal of Physiology. Cell Physiology. 299: C1153-61. PMID 20686069 DOI: 10.1152/Ajpcell.00113.2010 |
0.788 |
|
| 2010 |
Zhao R, Unal ES, Shin DS, Goldman ID. Membrane topological analysis of the proton-coupled folate transporter (PCFT-SLC46A1) by the substituted cysteine accessibility method. Biochemistry. 49: 2925-31. PMID 20225891 DOI: 10.1021/Bi9021439 |
0.77 |
|
| 2010 |
Bozard BR, Ganapathy PS, Duplantier J, Mysona B, Ha Y, Roon P, Smith R, Goldman ID, Prasad P, Martin PM, Ganapathy V, Smith SB. Molecular and biochemical characterization of folate transport proteins in retinal Müller cells. Investigative Ophthalmology & Visual Science. 51: 3226-35. PMID 20053979 DOI: 10.1167/Iovs.09-4833 |
0.476 |
|
| 2010 |
Goldman ID. Abstract IA6-1: The evolution of folate analogs: Drugs targeted to folate transporters, drugs targeted to novel enzyme sites, effects on signaling pathways Clinical Cancer Research. 16. DOI: 10.1158/1078-0432.Tcmusa10-Ia6-1 |
0.51 |
|
| 2009 |
Diop-Bove NK, Wu J, Zhao R, Locker J, Goldman ID. Hypermethylation of the human proton-coupled folate transporter (SLC46A1) minimal transcriptional regulatory region in an antifolate-resistant HeLa cell line. Molecular Cancer Therapeutics. 8: 2424-31. PMID 19671745 DOI: 10.1158/1535-7163.Mct-08-0938 |
0.413 |
|
| 2009 |
Unal ES, Zhao R, Goldman ID. Role of the glutamate 185 residue in proton translocation mediated by the proton-coupled folate transporter SLC46A1. American Journal of Physiology. Cell Physiology. 297: C66-74. PMID 19403800 DOI: 10.1152/Ajpcell.00096.2009 |
0.791 |
|
| 2009 |
Unal ES, Zhao R, Chang MH, Fiser A, Romero MF, Goldman ID. The functional roles of the His247 and His281 residues in folate and proton translocation mediated by the human proton-coupled folate transporter SLC46A1. The Journal of Biological Chemistry. 284: 17846-57. PMID 19389703 DOI: 10.1074/Jbc.M109.008060 |
0.782 |
|
| 2009 |
Zhao R, Matherly LH, Goldman ID. Membrane transporters and folate homeostasis: intestinal absorption and transport into systemic compartments and tissues. Expert Reviews in Molecular Medicine. 11: e4. PMID 19173758 DOI: 10.1017/S1462399409000969 |
0.506 |
|
| 2009 |
Zhao R, Min SH, Wang Y, Campanella E, Low PS, Goldman ID. A role for the proton-coupled folate transporter (PCFT-SLC46A1) in folate receptor-mediated endocytosis. The Journal of Biological Chemistry. 284: 4267-74. PMID 19074442 DOI: 10.1074/Jbc.M807665200 |
0.544 |
|
| 2008 |
Min SH, Oh SY, Karp GI, Poncz M, Zhao R, Goldman ID. The clinical course and genetic defect in the PCFT gene in a 27-year-old woman with hereditary folate malabsorption. The Journal of Pediatrics. 153: 435-7. PMID 18718264 DOI: 10.1016/J.Jpeds.2008.04.009 |
0.353 |
|
| 2008 |
Zhao R, Qiu A, Tsai E, Jansen M, Akabas MH, Goldman ID. The proton-coupled folate transporter: impact on pemetrexed transport and on antifolates activities compared with the reduced folate carrier. Molecular Pharmacology. 74: 854-62. PMID 18524888 DOI: 10.1124/Mol.108.045443 |
0.54 |
|
| 2008 |
Unal ES, Zhao R, Qiu A, Goldman ID. N-linked glycosylation and its impact on the electrophoretic mobility and function of the human proton-coupled folate transporter (HsPCFT). Biochimica Et Biophysica Acta. 1778: 1407-14. PMID 18405659 DOI: 10.1016/J.Bbamem.2008.03.009 |
0.784 |
|
| 2008 |
Wollack JB, Makori B, Ahlawat S, Koneru R, Picinich SC, Smith A, Goldman ID, Qiu A, Cole PD, Glod J, Kamen B. Characterization of folate uptake by choroid plexus epithelial cells in a rat primary culture model. Journal of Neurochemistry. 104: 1494-503. PMID 18086128 DOI: 10.1111/J.1471-4159.2007.05095.X |
0.498 |
|
| 2008 |
Chattopadhyay S, Tamari R, Min SH, Zhao R, Tsai E, Goldman ID. Commentary: a case for minimizing folate supplementation in clinical regimens with pemetrexed based on the marked sensitivity of the drug to folate availability. The Oncologist. 12: 808-15. PMID 17673612 DOI: 10.1634/Theoncologist.12-7-808 |
0.372 |
|
| 2007 |
Qiu A, Min SH, Jansen M, Malhotra U, Tsai E, Cabelof DC, Matherly LH, Zhao R, Akabas MH, Goldman ID. Rodent intestinal folate transporters (SLC46A1): secondary structure, functional properties, and response to dietary folate restriction. American Journal of Physiology. Cell Physiology. 293: C1669-78. PMID 17898134 DOI: 10.1152/Ajpcell.00202.2007 |
0.507 |
|
| 2007 |
Min SH, Goldman ID, Zhao R. Caffeine markedly sensitizes human mesothelioma cell lines to pemetrexed. Cancer Chemotherapy and Pharmacology. 61: 819-27. PMID 17594092 DOI: 10.1007/S00280-007-0539-Z |
0.344 |
|
| 2007 |
Li T, Ling YH, Goldman ID, Perez-Soler R. Schedule-dependent cytotoxic synergism of pemetrexed and erlotinib in human non-small cell lung cancer cells. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 13: 3413-22. PMID 17545550 DOI: 10.1158/1078-0432.Ccr-06-2923 |
0.332 |
|
| 2007 |
Zhao R, Min SH, Qiu A, Sakaris A, Goldberg GL, Sandoval C, Malatack JJ, Rosenblatt DS, Goldman ID. The spectrum of mutations in the PCFT gene, coding for an intestinal folate transporter, that are the basis for hereditary folate malabsorption. Blood. 110: 1147-52. PMID 17446347 DOI: 10.1182/Blood-2007-02-077099 |
0.438 |
|
| 2007 |
Zhao R, Goldman ID. The molecular identity and characterization of a Proton-coupled Folate Transporter--PCFT; biological ramifications and impact on the activity of pemetrexed. Cancer Metastasis Reviews. 26: 129-39. PMID 17340171 DOI: 10.1007/S10555-007-9047-1 |
0.545 |
|
| 2007 |
Chattopadhyay S, Moran RG, Goldman ID. Pemetrexed: biochemical and cellular pharmacology, mechanisms, and clinical applications. Molecular Cancer Therapeutics. 6: 404-17. PMID 17308042 DOI: 10.1158/1535-7163.Mct-06-0343 |
0.51 |
|
| 2006 |
Qiu A, Jansen M, Sakaris A, Min SH, Chattopadhyay S, Tsai E, Sandoval C, Zhao R, Akabas MH, Goldman ID. Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption. Cell. 127: 917-28. PMID 17129779 DOI: 10.1016/J.Cell.2006.09.041 |
0.525 |
|
| 2006 |
Chattopadhyay S, Zhao R, Tsai E, Schramm VL, Goldman ID. The effect of a novel transition state inhibitor of methylthioadenosine phosphorylase on pemetrexed activity Molecular Cancer Therapeutics. 5: 2549-2555. PMID 17041099 DOI: 10.1158/1535-7163.Mct-06-0313 |
0.36 |
|
| 2006 |
Chattopadhyay S, Zhao R, Krupenko SA, Krupenko N, Goldman ID. The inverse relationship between reduced folate carrier function and pemetrexed activity in a human colon cancer cell line. Molecular Cancer Therapeutics. 5: 438-49. PMID 16505119 DOI: 10.1158/1535-7163.Mct-05-0243 |
0.416 |
|
| 2005 |
Zhao R, Hanscom M, Goldman ID. The relationship between folate transport activity at low pH and reduced folate carrier function in human Huh7 hepatoma cells. Biochimica Et Biophysica Acta. 1715: 57-64. PMID 16109384 DOI: 10.1016/J.Bbamem.2005.07.003 |
0.47 |
|
| 2005 |
Zhao R, Zhang S, Hanscom M, Chattopadhyay S, Goldman ID. Loss of reduced folate carrier function and folate depletion result in enhanced pemetrexed inhibition of purine synthesis. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 11: 1294-301. PMID 15709201 |
0.304 |
|
| 2005 |
Zhao R, Chattopadhyay S, Hanscom M, Goldman ID. Antifolate resistance in a HeLa cell line associated with impaired transport independent of the reduced folate carrier. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 8735-42. PMID 15623659 DOI: 10.1158/1078-0432.Ccr-04-0932 |
0.493 |
|
| 2005 |
Chattopadhyay S, Wang Y, Zhao R, Goldman ID. Lack of impact of the loss of constitutive folate receptor alpha expression, achieved by RNA Interference, on the activity of the new generation antifolate pemetrexed in HeLa cells. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 7986-93. PMID 15585634 DOI: 10.1158/1078-0432.Ccr-04-1225 |
0.372 |
|
| 2005 |
Wang Y, Zhao R, Goldman ID. Characterization of a folate transporter in HeLa cells with a low pH optimum and high affinity for pemetrexed distinct from the reduced folate carrier. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 6256-64. PMID 15448015 DOI: 10.1158/1078-0432.Ccr-04-0645 |
0.454 |
|
| 2004 |
Wang Y, Rajgopal A, Goldman ID, Zhao R. Preservation of folate transport activity with a low-pH optimum in rat IEC-6 intestinal epithelial cell lines that lack reduced folate carrier function. American Journal of Physiology. Cell Physiology. 288: C65-71. PMID 15385270 DOI: 10.1152/Ajpcell.00307.2004 |
0.515 |
|
| 2004 |
Zhao R, Hanscom M, Chattopadhyay S, Goldman ID. Selective preservation of pemetrexed pharmacological activity in HeLa cells lacking the reduced folate carrier: association with the presence of a secondary transport pathway. Cancer Research. 64: 3313-9. PMID 15126375 DOI: 10.1158/0008-5472.Can-03-3953 |
0.468 |
|
| 2004 |
Zhao R, Gao F, Hanscom M, Goldman ID. A prominent low-pH methotrexate transport activity in human solid tumors: contribution to the preservation of methotrexate pharmacologic activity in HeLa cells lacking the reduced folate carrier. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 718-27. PMID 14760095 DOI: 10.1158/1078-0432.Ccr-1066-03 |
0.437 |
|
| 2003 |
Zhao R, Goldman ID. Resistance to antifolates. Oncogene. 22: 7431-57. PMID 14576850 DOI: 10.1038/Sj.Onc.1206946 |
0.34 |
|
| 2003 |
Stark M, Rothem L, Jansen G, Scheffer GL, Goldman ID, Assaraf YG. Antifolate resistance associated with loss of MRP1 expression and function in Chinese hamster ovary cells with markedly impaired export of folate and cholate. Molecular Pharmacology. 64: 220-7. PMID 12869626 DOI: 10.1124/Mol.64.2.220 |
0.418 |
|
| 2003 |
Zhao R, Wang Y, Gao F, Goldman ID. Residues 45 and 404 in the murine reduced folate carrier may interact to alter carrier binding and mobility. Biochimica Et Biophysica Acta. 1613: 49-56. PMID 12832086 DOI: 10.1016/S0005-2736(03)00136-6 |
0.472 |
|
| 2003 |
Wang Y, Zhao R, Goldman ID. Decreased expression of the reduced folate carrier and folypolyglutamate synthetase is the basis for acquired resistance to the pemetrexed antifolate (LY231514) in an L1210 murine leukemia cell line. Biochemical Pharmacology. 65: 1163-70. PMID 12663051 DOI: 10.1016/S0006-2952(03)00007-8 |
0.415 |
|
| 2003 |
Goldman ID, Zhao R. Molecular, biochemical, and cellular pharmacology of pemetrexed. Seminars in Oncology. 29: 3-17. PMID 12571805 DOI: 10.1053/sonc.2002.37461 |
0.376 |
|
| 2002 |
Wang Y, Zhao R, Chattopadhyay S, Goldman ID. A novel folate transport activity in human mesothelioma cell lines with high affinity and specificity for the new-generation antifolate, pemetrexed. Cancer Research. 62: 6434-7. PMID 12438230 |
0.417 |
|
| 2002 |
Sharina IG, Zhao R, Wang Y, Babani S, Goldman ID. Role of the C-terminus and the long cytoplasmic loop in reduced folate carrier expression and function. Biochemical Pharmacology. 63: 1717-24. PMID 12007575 DOI: 10.1016/S0006-2952(02)00955-3 |
0.49 |
|
| 2002 |
Zhao R, Gao F, Goldman ID. Reduced folate carrier transports thiamine monophosphate: an alternative route for thiamine delivery into mammalian cells. American Journal of Physiology. Cell Physiology. 282: C1512-7. PMID 11997266 DOI: 10.1152/Ajpcell.00547.2001 |
0.541 |
|
| 2002 |
Rajgopal A, Edmondnson A, Goldman ID, Zhao R. SLC19A3 encodes a second thiamine transporter ThTr2. Biochimica Et Biophysica Acta. 1537: 175-8. PMID 11731220 DOI: 10.1016/S0925-4439(01)00073-4 |
0.514 |
|
| 2002 |
GOLDMAN I, ZHAO R. Molecular, biochemical, and cellular pharmacology of pemetrexed Seminars in Oncology. 29: 3-17. DOI: 10.1016/S0093-7754(02)70040-7 |
0.468 |
|
| 2001 |
Rajgopal A, Sierra EE, Zhao R, Goldman ID. Expression of the reduced folate carrier SLC19A1 in IEC-6 cells results in two distinct transport activities. American Journal of Physiology. Cell Physiology. 281: C1579-86. PMID 11600421 DOI: 10.1152/Ajpcell.2001.281.5.C1579 |
0.456 |
|
| 2001 |
Wang Y, Zhao R, Russell RG, Goldman ID. Localization of the murine reduced folate carrier as assessed by immunohistochemical analysis. Biochimica Et Biophysica Acta. 1513: 49-54. PMID 11427193 DOI: 10.1016/S0005-2736(01)00340-6 |
0.419 |
|
| 2001 |
Sharina IG, Zhao R, Wang Y, Babani S, Goldman ID. Mutational analysis of the functional role of conserved arginine and lysine residues in transmembrane domains of the murine reduced folate carrier. Molecular Pharmacology. 59: 1022-8. PMID 11306683 DOI: 10.1124/Mol.59.5.1022 |
0.485 |
|
| 2001 |
Zhao R, Gao F, Goldman ID. Marked suppression of the activity of some, but not all, antifolate compounds by augmentation of folate cofactor pools within tumor cells. Biochemical Pharmacology. 61: 857-65. PMID 11274972 DOI: 10.1016/S0006-2952(01)00532-9 |
0.343 |
|
| 2001 |
Zhao R, Russell RG, Wang Y, Liu L, Gao F, Kneitz B, Edelmann W, Goldman ID. Rescue of embryonic lethality in reduced folate carrier-deficient mice by maternal folic acid supplementation reveals early neonatal failure of hematopoietic organs. The Journal of Biological Chemistry. 276: 10224-8. PMID 11266438 DOI: 10.1074/Jbc.C000905200 |
0.309 |
|
| 2001 |
Zhao R, Gao F, Wang Y, Diaz GA, Gelb BD, Goldman ID. Impact of the reduced folate carrier on the accumulation of active thiamin metabolites in murine leukemia cells Journal of Biological Chemistry. 276: 1114-1118. PMID 11038362 DOI: 10.1074/Jbc.M007919200 |
0.525 |
|
| 2001 |
Zhao R, Babani S, Gao F, Liu L, Goldman ID. The mechanism of transport of the multitargeted antifolate (MTA) and its cross-resistance pattern in cells with markedly impaired transport of methotrexate. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 6: 3687-95. PMID 10999762 |
0.385 |
|
| 2000 |
Zhao R, Gao F, Babani S, Goldman ID. Sensitivity to 5,10-dideazatetrahydrofolate is fully conserved in a murine leukemia cell line highly resistant to methotrexate due to impaired transport mediated by the reduced folate carrier. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 6: 3304-11. PMID 10955817 |
0.404 |
|
| 2000 |
Zhao R, Titus S, Gao F, Moran RG, Goldman ID. Molecular analysis of murine leukemia cell lines resistant to 5, 10-dideazatetrahydrofolate identifies several amino acids critical to the function of folylpolyglutamate synthetase. The Journal of Biological Chemistry. 275: 26599-606. PMID 10856298 DOI: 10.1074/Jbc.M002580200 |
0.441 |
|
| 2000 |
Zhao R, Gao F, Liu L, Goldman ID. The reduced folate carrier in L1210 murine leukemia cells is a 58-kDa protein. Biochimica Et Biophysica Acta. 1466: 7-10. PMID 10825425 DOI: 10.1016/S0005-2736(00)00190-5 |
0.393 |
|
| 2000 |
Sharif KA, Goldman ID. Rapid determination of membrane transport parameters in adherent cells Biotechniques. 28: 926-932. PMID 10818699 DOI: 10.2144/00285St06 |
0.487 |
|
| 2000 |
Drori S, Sprecher H, Shemer G, Jansen G, Goldman ID, Assaraf YG. Characterization of a human alternatively spliced truncated reduced folate carrier increasing folate accumulation in parental leukemia cells. European Journal of Biochemistry. 267: 690-702. PMID 10651805 DOI: 10.1046/J.1432-1327.2000.01049.X |
0.471 |
|
| 2000 |
Zhao R, Gao F, Wang PJ, Goldman ID. Role of the amino acid 45 residue in reduced folate carrier function and ion-dependent transport as characterized by site-directed mutagenesis. Molecular Pharmacology. 57: 317-23. PMID 10648641 |
0.354 |
|
| 1999 |
Sierra EE, Goldman ID. Recent advances in the understanding of the mechanism of membrane transport of folates and antifolates. Seminars in Oncology. 26: 11-23. PMID 10598550 |
0.469 |
|
| 1999 |
Zhao R, Gao F, Goldman ID. Discrimination among reduced folates and methotrexate as transport substrates by a phenylalanine substitution for serine within the predicted eighth transmembrane domain of the reduced folate carrier. Biochemical Pharmacology. 58: 1615-24. PMID 10535753 DOI: 10.1016/S0006-2952(99)00257-9 |
0.469 |
|
| 1999 |
Assaraf YG, Sierra EE, Babani S, Goldman ID. Inhibitory effects of prostaglandin A1 on membrane transport of folates mediated by both the reduced folate carrier and ATP-driven exporters. Biochemical Pharmacology. 58: 1321-7. PMID 10487535 DOI: 10.1016/S0006-2952(99)00227-0 |
0.498 |
|
| 1999 |
Zhao R, Sharina IG, Goldman ID. Pattern of mutations that results in loss of reduced folate carrier function under antifolate selective pressure augmented by chemical mutagenesis. Molecular Pharmacology. 56: 68-76. PMID 10385685 |
0.36 |
|
| 1999 |
Sierra EE, Goldman ID. Characterization of folate transport mediated by a low pH route in mouse L1210 leukemia cells with defective reduced folate carrier function. Biochemical Pharmacology. 55: 1505-12. PMID 10076544 DOI: 10.1016/S0006-2952(97)00673-4 |
0.428 |
|
| 1999 |
Zhao R, Sharina IG, Goldman ID. Pattern of Mutations that Results in Loss of Reduced Folate Carrier Function under Antifolate Selective Pressure Augmented by Chemical Mutagenesis Molecular Pharmacology. 56: 68-76. DOI: 10.1124/Mol.56.1.68 |
0.462 |
|
| 1998 |
Zhao R, Assaraf YG, Goldman ID. A mutated murine reduced folate carrier (RFC1) with increased affinity for folic acid, decreased affinity for methotrexate, and an obligatory anion requirement for transport function. The Journal of Biological Chemistry. 273: 19065-71. PMID 9668089 DOI: 10.1074/Jbc.273.30.19065 |
0.477 |
|
| 1998 |
Sharif KA, Moscow JA, Goldman ID. Concentrating capacity of the human reduced folate carrier (hRFC1) in human ZR-75 breast cancer cell lines Biochemical Pharmacology. 55: 1683-1689. PMID 9634005 DOI: 10.1016/S0006-2952(98)00039-2 |
0.46 |
|
| 1998 |
Assaraf YG, Babani S, Goldman ID. Increased activity of a novel low pH folate transporter associated with lipophilic antifolate resistance in chinese hamster ovary cells. The Journal of Biological Chemistry. 273: 8106-11. PMID 9525913 DOI: 10.1074/jbc.273.14.8106 |
0.341 |
|
| 1998 |
Zhao R, Assaraf YG, Goldman ID. A reduced folate carrier mutation produces substrate-dependent alterations in carrier mobility in murine leukemia cells and methotrexate resistance with conservation of growth in 5-formyltetrahydrofolate. The Journal of Biological Chemistry. 273: 7873-9. PMID 9525881 DOI: 10.1074/Jbc.273.14.7873 |
0.463 |
|
| 1997 |
Brigle KE, Spinella MJ, Sierra EE, Goldman ID. Organization of the murine reduced folate carrier gene and identification of variant splice forms. Biochimica Et Biophysica Acta. 1353: 191-8. PMID 9294013 DOI: 10.1016/S0167-4781(97)00082-1 |
0.305 |
|
| 1997 |
Zhao R, Seither R, Brigle KE, Sharina IG, Wang PJ, Goldman ID. Impact of overexpression of the reduced folate carrier (RFC1), an anion exchanger, on concentrative transport in murine L1210 leukemia cells. The Journal of Biological Chemistry. 272: 21207-12. PMID 9261128 DOI: 10.1074/Jbc.272.34.21207 |
0.489 |
|
| 1997 |
Assaraf YG, Goldman ID. Loss of folic acid exporter function with markedly augmented folate accumulation in lipophilic antifolate-resistant mammalian cells. The Journal of Biological Chemistry. 272: 17460-6. PMID 9211890 DOI: 10.1074/jbc.272.28.17460 |
0.338 |
|
| 1997 |
Sierra EE, Brigle KE, Spinella MJ, Goldman ID. pH dependence of methotrexate transport by the reduced folate carrier and the folate receptor in L1210 leukemia cells. Further evidence for a third route mediated at low pH. Biochemical Pharmacology. 53: 223-31. PMID 9037255 DOI: 10.1016/S0006-2952(96)00730-7 |
0.389 |
|
| 1996 |
Spinella MJ, Brigle KE, Freemantle SJ, Sierra EE, Goldman ID. Comparison of methotrexate polyglutamylation in L1210 leukemia cells when influx is mediated by the reduced folate carrier or the folate receptor. Lack of evidence for influx route-specific effects. Biochemical Pharmacology. 52: 703-12. PMID 8765468 DOI: 10.1016/0006-2952(96)00347-4 |
0.348 |
|
| 1995 |
Spinella MJ, Brigle KE, Sierra EE, Goldman ID. Distinguishing between folate receptor-alpha-mediated transport and reduced folate carrier-mediated transport in L1210 leukemia cells. The Journal of Biological Chemistry. 270: 7842-9. PMID 7713875 DOI: 10.1074/Jbc.270.14.7842 |
0.347 |
|
| 1995 |
Brigle KE, Spinella MJ, Sierra EE, Goldman ID. Characterization of a mutation in the reduced folate carrier in a transport defective L1210 murine leukemia cell line. The Journal of Biological Chemistry. 270: 22974-9. PMID 7559435 DOI: 10.1074/Jbc.270.39.22974 |
0.338 |
|
| 1995 |
Sierra EE, Brigle KE, Spinella MJ, Goldman ID. Comparison of transport properties of the reduced folate carrier and folate receptor in murine L1210 leukemia cells. Biochemical Pharmacology. 50: 1287-94. PMID 7488246 DOI: 10.1016/0006-2952(95)94097-Y |
0.307 |
|
| 1989 |
Schuetz JD, Westin EH, Matherly LH, Pincus R, Swerdlow PS, Goldman ID. Membrane protein changes in an L1210 leukemia cell line with a translocation defect in the methotrexate-tetrahydrofolate cofactor transport carrier Journal of Biological Chemistry. 264: 16261-16267. PMID 2777791 |
0.361 |
|
| 1988 |
Schuetz JD, Matherly LH, Westin EH, Goldman ID. Evidence for a functional defect in the translocation of the methotrexate transport carrier in a methotrexate-resistant murine L1210 leukemia cell line Journal of Biological Chemistry. 263: 9840-9847. PMID 2838483 |
0.366 |
|
| 1985 |
Fabre G, Fabre I, Gewirtz DA, Goldman ID. Characteristics of the formation and membrane transport of 7-hydroxymethotrexate in freshly isolated rabbit hepatocytes. Cancer Research. 45: 1086-91. PMID 2578871 |
0.414 |
|
| 1985 |
Matherly LH, Voss MK, Anderson LA, Fry DW, Goldman ID. Enhanced Polyglutamylation of Aminopterin Relative to Methotrexate in the Ehrlich Ascites Tumor Cell in vitro Cancer Research. 45: 1073-1078. PMID 2578870 |
0.322 |
|
| 1984 |
Yalowich JC, Goldman ID. Analysis of the inhibitory effects of VP-16-213 (etoposide) and podophyllotoxin on thymidine transport and metabolism in Ehrlich ascites tumor cells in vitro. Cancer Research. 44: 984-9. PMID 6692420 |
0.407 |
|
| 1984 |
Fabre G, Matherly LH, Fabre I, Cano JP, Goldman ID. Interactions Between 7-Hydroxymethotrexate and Methotrexate at the Cellular Level in the Ehrlich Ascites Tumor in Vitro Cancer Research. 44: 970-975. PMID 6692419 |
0.36 |
|
| 1982 |
Fry DW, Goldman ID. Further studies on the charge-related alterations of methotrexate transport in Ehrlich ascites tumor cells by ionic liposomes: correlation with liposome-cell association. The Journal of Membrane Biology. 66: 87-95. PMID 7077651 DOI: 10.1007/BF01868485 |
0.336 |
|
| 1982 |
Yalowich JC, Fry DW, Goldman ID. Teniposide (VM-26)- and etoposide (VP-16-213)-induced augmentation of methotrexate transport and polyglutamylation in Ehrlich ascites tumor cells in vitro. Cancer Research. 42: 3648-53. PMID 6179605 |
0.312 |
|
| 1982 |
Cybulski RL, Fry DW, Goldman ID. Approaches to the measurement of intracellular adenine and the discrimination between adenine transport and metabolism in L1210 leukemia cells. Biochimica Et Biophysica Acta. 714: 435-41. PMID 6174155 DOI: 10.1016/0304-4165(82)90151-9 |
0.352 |
|
| 1981 |
Fry DW, White JC, Goldman ID. Effects of 2,4-dinitrophenol and other metabolic inhibitors on the bidirectional carrier fluxes, net transport, and intracellular binding of methotrexate in Ehrlich ascites tumor cells. Cancer Research. 40: 3669-73. PMID 7438050 |
0.313 |
|
| 1981 |
Fry DW, Cybulski RL, Goldman ID. K+-induced alterations of energetics and exchange diffusion in the carrier-mediated transport of the folic acid analog, methotrexate, in Ehrlich ascites tumor cells. Biochimica Et Biophysica Acta. 603: 157-70. PMID 7192570 DOI: 10.1016/0005-2736(80)90398-3 |
0.307 |
|
| 1980 |
Gewirtz AD, White JC, Randolph JK, Goldman ID. Transport, Binding, and Polyglutamation of Methotrexate in Freshly Isolated Rat Hepatocytes Cancer Research. 40: 573-578. PMID 6162551 |
0.423 |
|
| 1980 |
White JC, Carchman RA, Fry DW, Goldman ID. Relationship between membrane transport of methotrexate and endogenous cyclic adenosine 3':5'-monophosphate in the Ehrlich ascites tumor. Cancer Research. 40: 2400-4. PMID 6155994 |
0.383 |
|
| 1980 |
Fry DW, White JC, Goldman ID. Alterations of the carrier-mediated transport of an anionic solute, methotrexate, by charged liposomes in Ehrlich ascites tumor cells. The Journal of Membrane Biology. 50: 123-40. PMID 501733 DOI: 10.1007/BF01868944 |
0.355 |
|
| 1979 |
Hill BT, Bailey BD, White JC, Goldman ID. Characteristics of transport of 4-amino antifolates and folate compounds by two lines of L5178Y lymphoblasts, one with impaired transport of methotrexate. Cancer Research. 39: 2440-6. PMID 221104 |
0.34 |
|
| 1978 |
White JC, Bailey BD, Goldman ID. Lack of stereospecificity at carbon 6 of methyltetrahydrofolate transport in Ehrlich ascites tumor cells. Carrier-mediated transport of both stereoisomers. The Journal of Biological Chemistry. 253: 242-5. PMID 618860 |
0.386 |
|
| 1977 |
Goldman ID, Fyfe JM, Bowen D, Loftfield S, Schafer JA. The effect of microtubular inhibitors on transport of alpha-aminoisobutyric acid. Inhibition of uphill transport without changes in transmembrane gradients of Na+, K+, or H+. Biochimica Et Biophysica Acta. 467: 185-91. PMID 18176 DOI: 10.1016/0005-2736(77)90195-X |
0.318 |
|
| 1976 |
Jennette JC, Goldman ID. Inhibition of the membrane transport of folates by anions retained in uremia. The Journal of Laboratory and Clinical Medicine. 86: 834-43. PMID 1185041 |
0.405 |
|
| 1972 |
Goldman ID. The characteristics of the membrane transport of amethopterin and the naturally occurring folates. Annals of the New York Academy of Sciences. 186: 400-22. PMID 5289428 DOI: 10.1111/j.1749-6632.1971.tb46996.x |
0.314 |
|
| 1972 |
Bobzien WF, Goldman ID. The mechanism of folate transport in rabbit reticulocytes. The Journal of Clinical Investigation. 51: 1688-96. PMID 5032520 DOI: 10.1172/JCI106970 |
0.382 |
|
| 1970 |
Lilien DL, Spivak JL, Goldman ID. Chromate transport in human leukocytes. The Journal of Clinical Investigation. 49: 1551-7. PMID 5431664 DOI: 10.1172/JCI106372 |
0.318 |
|
| 1969 |
Goldman ID. Transport energetics of the folic acid analogue, methotrexate, in L1210 leukemia cells. Enhanced accumulation by metabolic inhibitors. The Journal of Biological Chemistry. 244: 3779-85. PMID 5805398 |
0.308 |
|
| 1969 |
Lichtenstein NS, Oliverio VT, Goldman ID. Characteristics of folic acid transport in the L1210 leukemia cell. Biochimica Et Biophysica Acta. 193: 456-67. PMID 5389249 DOI: 10.1016/0005-2736(69)90204-1 |
0.308 |
|
| 1968 |
Goldman ID, Lichtenstein NS, Oliverio VT. Carrier-mediated transport of the folic acid analogue, methotrexate, in the L1210 leukemia cell. The Journal of Biological Chemistry. 243: 5007-17. PMID 5303004 |
0.333 |
|
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