David T. Dexter, Ph.D. - Publications

Affiliations: 
Brain sciences, Medicine Imperial College, London, London, England, United Kingdom 
Area:
Neurodegeneration, iron metabolism, neuroinflammation
Website:
http://www1.imperial.ac.uk/medicine/people/d.dexter/

54 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Al-Zaid FS, Hurley MJ, Dexter DT, Gillies GE. Neuroprotective role for RORA in Parkinson's disease revealed by analysis of post-mortem brain and a dopaminergic cell line. Npj Parkinson's Disease. 9: 119. PMID 37500636 DOI: 10.1038/s41531-023-00563-4  0.311
2020 Lewis FW, Fairooz S, Elson JL, Hubscher-Bruder V, Brandel J, Soundararajan M, Smith D, Dexter DT, Tétard D, Pienaar IS. Novel 1-hydroxypyridin-2-one metal chelators prevent and rescue ubiquitin proteasomal-related neuronal injury in an in vitro model of Parkinson's disease. Archives of Toxicology. PMID 32078022 DOI: 10.1007/S00204-020-02672-Y  0.34
2020 Sharma PK, Wells L, Rizzo G, Elson JL, Passchier J, Rabiner EA, Gunn RN, Dexter DT, Pienaar IS. DREADD Activation of Pedunculopontine Cholinergic Neurons Reverses Motor Deficits and Restores Striatal Dopamine Signaling in Parkinsonian Rats. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 31965550 DOI: 10.1007/S13311-019-00830-4  0.421
2019 Gonzalez-Carter D, Goode AE, Kiryushko D, Masuda S, Hu S, Lopes-Rodrigues R, Dexter DT, Shaffer MSP, Porter AE. Quantification of blood-brain barrier transport and neuronal toxicity of unlabelled multiwalled carbon nanotubes as a function of surface charge. Nanoscale. PMID 31720664 DOI: 10.1039/C9Nr02866H  0.408
2018 Harrison IF, Powell NM, Dexter DT. The Histone Deacetylase Inhibitor Nicotinamide Exacerbates Neurodegeneration in the Lactacystin Rat Model of Parkinson's Disease. Journal of Neurochemistry. PMID 30269333 DOI: 10.1111/Jnc.14599  0.701
2018 Gonzalez-Carter D, Ong ZY, McGilvery CM, Dunlop IE, Dexter DT, Porter AE. L-DOPA functionalized, multi-branched gold nanoparticles as brain-targeted Nano-vehicles. Nanomedicine : Nanotechnology, Biology, and Medicine. PMID 30189294 DOI: 10.1016/J.Nano.2018.08.011  0.357
2018 Pankratova S, Klingelhofer J, Dmytriyeva O, Owczarek S, Renziehausen A, Syed N, Porter AE, Dexter DT, Kiryushko D. The S100A4 Protein Signals through the ErbB4 Receptor to Promote Neuronal Survival. Theranostics. 8: 3977-3990. PMID 30083275 DOI: 10.7150/Thno.22274  0.365
2018 Moreau C, Duce JA, Rascol O, Devedjian JC, Berg D, Dexter D, Cabantchik ZI, Bush AI, Devos D. Iron as a therapeutic target for Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 29380903 DOI: 10.1002/Mds.27275  0.318
2017 Harrison IF, Smith AD, Dexter DT. Pathological histone acetylation in Parkinson's disease: Neuroprotection and inhibition of microglial activation through SIRT 2 inhibition. Neuroscience Letters. 666: 48-57. PMID 29273397 DOI: 10.1016/J.Neulet.2017.12.037  0.693
2017 Martin-Bastida A, Ward RJ, Newbould R, Piccini P, Sharp D, Kabba C, Patel MC, Spino M, Connelly J, Tricta F, Crichton RR, Dexter DT. Brain iron chelation by deferiprone in a phase 2 randomised double-blinded placebo controlled clinical trial in Parkinson's disease. Scientific Reports. 7: 1398. PMID 28469157 DOI: 10.1038/S41598-017-01402-2  0.349
2017 Gonzalez-Carter DA, Leo BF, Ruenraroengsak P, Chen S, Goode AE, Theodorou IG, Chung KF, Carzaniga R, Shaffer MS, Dexter DT, Ryan MP, Porter AE. Silver nanoparticles reduce brain inflammation and related neurotoxicity through induction of H2S-synthesizing enzymes. Scientific Reports. 7: 42871. PMID 28251989 DOI: 10.1038/Srep42871  0.406
2015 Harrison IF, Anis HK, Dexter DT. Associated Degeneration of Ventral Tegmental Area Dopaminergic Neurons in the Rat Nigrostriatal Lactacystin Model of Parkinsonism and their Neuroprotection by Valproate. Neuroscience Letters. PMID 26742637 DOI: 10.1016/J.Neulet.2015.12.052  0.691
2015 Pienaar IS, Gartside SE, Sharma P, De Paola V, Gretenkord S, Withers D, Elson JL, Dexter DT. Pharmacogenetic stimulation of cholinergic pedunculopontine neurons reverses motor deficits in a rat model of Parkinson's disease. Molecular Neurodegeneration. 10: 47. PMID 26394842 DOI: 10.1186/S13024-015-0044-5  0.448
2015 Goode AE, Gonzalez Carter DA, Motskin M, Pienaar IS, Chen S, Hu S, Ruenraroengsak P, Ryan MP, Shaffer MS, Dexter DT, Porter AE. High resolution and dynamic imaging of biopersistence and bioreactivity of extra and intracellular MWNTs exposed to microglial cells. Biomaterials. 70: 57-70. PMID 26298523 DOI: 10.1016/J.Biomaterials.2015.08.019  0.662
2015 Brauer R, Bhaskaran K, Chaturvedi N, Dexter DT, Smeeth L, Douglas I. Glitazone Treatment and Incidence of Parkinson's Disease among People with Diabetes: A Retrospective Cohort Study. Plos Medicine. 12: e1001854. PMID 26196151 DOI: 10.1371/Journal.Pmed.1001854  0.37
2015 Harrison IF, Crum WR, Vernon AC, Dexter DT. Neurorestoration Induced by the HDAC Inhibitor Sodium Valproate in the Lactacystin Model of Parkinson's is Associated with Histone Acetylation and Upregulation of Neurotrophic Factors. British Journal of Pharmacology. PMID 26040297 DOI: 10.1111/Bph.13208  0.729
2015 Hurley MJ, Durrenberger PF, Gentleman SM, Walls AF, Dexter DT. Altered Expression of Brain Proteinase-Activated Receptor-2, Trypsin-2 and Serpin Proteinase Inhibitors in Parkinson's Disease. Journal of Molecular Neuroscience : Mn. PMID 25982926 DOI: 10.1007/S12031-015-0576-8  0.377
2015 Ward RJ, Dexter DT, Crichton RR. Ageing, neuroinflammation and neurodegeneration. Frontiers in Bioscience (Scholar Edition). 7: 189-204. PMID 25961695 DOI: 10.2741/S433  0.368
2015 Ward RJ, Dexter DT, Crichton RR. Neurodegenerative diseases and therapeutic strategies using iron chelators. Journal of Trace Elements in Medicine and Biology : Organ of the Society For Minerals and Trace Elements (Gms). 31: 267-73. PMID 25716300 DOI: 10.1016/J.Jtemb.2014.12.012  0.334
2015 Klioueva NM, Rademaker MC, Dexter DT, Al-Sarraj S, Seilhean D, Streichenberger N, Schmitz P, Bell JE, Ironside JW, Arzberger T, Huitinga I. BrainNet Europe's Code of Conduct for brain banking. Journal of Neural Transmission (Vienna, Austria : 1996). 122: 937-40. PMID 25578485 DOI: 10.1007/S00702-014-1353-5  0.308
2015 Pienaar IS, Lee CH, Elson JL, McGuinness L, Gentleman SM, Kalaria RN, Dexter DT. Deep-brain stimulation associates with improved microvascular integrity in the subthalamic nucleus in Parkinson's disease. Neurobiology of Disease. 74: 392-405. PMID 25533682 DOI: 10.1016/J.Nbd.2014.12.006  0.411
2015 Di Fruscia P, Zacharioudakis E, Liu C, Moniot S, Laohasinnarong S, Khongkow M, Harrison IF, Koltsida K, Reynolds CR, Schmidtkunz K, Jung M, Chapman KL, Steegborn C, Dexter DT, Sternberg MJ, et al. The discovery of a highly selective 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one SIRT2 inhibitor that is neuroprotective in an in vitro Parkinson's disease model. Chemmedchem. 10: 69-82. PMID 25395356 DOI: 10.1002/Cmdc.201402431  0.655
2015 Hurley MJ, Gentleman SM, Dexter DT. Calcium CaV1 channel subtype mRNA expression in Parkinson's disease examined by in situ hybridization. Journal of Molecular Neuroscience : Mn. 55: 715-24. PMID 25173401 DOI: 10.1007/S12031-014-0410-8  0.371
2015 Durrenberger PF, Fernando FS, Kashefi SN, Bonnert TP, Seilhean D, Nait-Oumesmar B, Schmitt A, Gebicke-Haerter PJ, Falkai P, Grünblatt E, Palkovits M, Arzberger T, Kretzschmar H, Dexter DT, Reynolds R. Common mechanisms in neurodegeneration and neuroinflammation: a BrainNet Europe gene expression microarray study. Journal of Neural Transmission (Vienna, Austria : 1996). 122: 1055-68. PMID 25119539 DOI: 10.1007/S00702-014-1293-0  0.36
2015 Pienaar IS, Harrison IF, Elson JL, Bury A, Woll P, Simon AK, Dexter DT. An animal model mimicking pedunculopontine nucleus cholinergic degeneration in Parkinson's disease. Brain Structure & Function. 220: 479-500. PMID 24292256 DOI: 10.1007/S00429-013-0669-5  0.687
2014 Williams CJ, Dexter DT. Neuroprotective and symptomatic effects of targeting group III mGlu receptors in neurodegenerative disease. Journal of Neurochemistry. 129: 4-20. PMID 24224472 DOI: 10.1111/Jnc.12608  0.514
2014 Ward RJ, Lallemand F, Dexter DT, De Witte P. SY39-4 * INFLUENCE OF SYSTEMIC INFLAMMATORY PROCESSES ON BRAIN IMMUNE SYSTEM Alcohol and Alcoholism. 49: i33-i33. DOI: 10.1093/Alcalc/Agu052.164  0.319
2014 Goode AE, Hine NDM, Chen S, Bergin SD, Motskin M, Gonzalez Carter DA, Dexter DT, Shaffer MSP, Ryan MP, Haynes PD, Porter AE, McComb DW. Electron microscopic characterization of functionalized multi-walled carbon nanotubes and their interactions with the blood brain barrier Microscopy and Microanalysis. 20: 1744-1745. DOI: 10.1017/S1431927614010459  0.648
2014 Reynolds R, Howell OW, Magliozzi R, Dexter DT, Durrenberger PF. In the search for molecular hallmarks of neuroinflammation in brain diseases Journal of Neuroimmunology. 275: 147. DOI: 10.1016/J.Jneuroim.2014.08.394  0.347
2013 Watts JC, Giles K, Oehler A, Middleton L, Dexter DT, Gentleman SM, DeArmond SJ, Prusiner SB. Transmission of multiple system atrophy prions to transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 110: 19555-60. PMID 24218576 DOI: 10.1073/Pnas.1318268110  0.321
2013 Hurley MJ, Brandon B, Gentleman SM, Dexter DT. Parkinson's disease is associated with altered expression of CaV1 channels and calcium-binding proteins. Brain : a Journal of Neurology. 136: 2077-97. PMID 23771339 DOI: 10.1093/Brain/Awt134  0.371
2013 Harrison IF, Dexter DT. Epigenetic targeting of histone deacetylase: therapeutic potential in Parkinson's disease? Pharmacology & Therapeutics. 140: 34-52. PMID 23711791 DOI: 10.1016/J.Pharmthera.2013.05.010  0.681
2013 Dexter DT, Jenner P. Parkinson disease: from pathology to molecular disease mechanisms. Free Radical Biology & Medicine. 62: 132-44. PMID 23380027 DOI: 10.1016/J.Freeradbiomed.2013.01.018  0.426
2012 Durrenberger PF, Grünblatt E, Fernando FS, Monoranu CM, Evans J, Riederer P, Reynolds R, Dexter DT. Inflammatory Pathways in Parkinson's Disease; A BNE Microarray Study. Parkinson's Disease. 2012: 214714. PMID 22548201 DOI: 10.1155/2012/214714  0.302
2011 Ward RJ, Lallemand F, de Witte P, Crichton RR, Piette J, Tipton K, Hemmings K, Pitard A, Page M, Della Corte L, Taylor D, Dexter D. Anti-inflammatory actions of a taurine analogue, ethane β-sultam, in phagocytic cells, in vivo and in vitro. Biochemical Pharmacology. 81: 743-51. PMID 21232527 DOI: 10.1016/J.Bcp.2010.12.030  0.326
2011 Harrison I, Dexter D. Magnetic Resonance Imaging as a tool for longitudinal monitoring in the lactacystin model of Parkinson's disease and studying the neuroprotective effects of valproate F1000research. 2. DOI: 10.7490/F1000Research.1089305.1  0.688
2011 Crichton R, Dexter DT, Ward RJ, Kalk N, Rabiner EA, Lingford-Hughes AR, Ward R, De Witte P, Lallemand F, Noel X, Campanella S, Verbank P, Crews F, Ward RJ. S14 * IDENTIFICATION OF NEUROINFLAMMATION IN THE BRAIN IN VIVO AND IN VITRO AND THERAPEUTIC STRATEGIES TO COMBAT ITS PROGRESSION * S14.1 * INFLAMMATORY PROCESSES IN NEURODEGENERATIVE DISEASES Alcohol and Alcoholism. 46: i13-i14. DOI: 10.1093/Alcalc/Agr104  0.345
2011 Ward R, De Witte P, Lallemand F, Corte LD, Dexter DT, Bakalkin G, Yakovleva T, Pascual-Mora M, Balino P, Alfonso-Loeches S, Aragon C, Guerri C, Crews F. S06 * ROLE OF INNATE IMMUNE SYSTEM IN THE ETHANOL-INDUCED BRAIN DAMAGE, BEHAVIOURAL DYSFUNCTIONS AND ADDICTION * S06.1 * BINGE DRINKING INDUCES SIGNIFICANT CHANGES IN THE INNATE IMMUNE SYSTEM Alcohol and Alcoholism. 46: i6-i7. DOI: 10.1093/Alcalc/Agr091  0.331
2010 Chan H, Paur H, Vernon AC, Zabarsky V, Datla KP, Croucher MJ, Dexter DT. Neuroprotection and Functional Recovery Associated with Decreased Microglial Activation Following Selective Activation of mGluR2/3 Receptors in a Rodent Model of Parkinson's Disease. Parkinson's Disease. 2010. PMID 20948891 DOI: 10.4061/2010/190450  0.598
2008 Vernon AC, Croucher MJ, Dexter DT. Additive neuroprotection by metabotropic glutamate receptor subtype-selective ligands in a rat Parkinson's model. Neuroreport. 19: 475-8. PMID 18287950 DOI: 10.1097/Wnr.0B013E3282F602Df  0.586
2007 Vernon AC, Zbarsky V, Datla KP, Croucher MJ, Dexter DT. Subtype selective antagonism of substantia nigra pars compacta Group I metabotropic glutamate receptors protects the nigrostriatal system against 6-hydroxydopamine toxicity in vivo. Journal of Neurochemistry. 103: 1075-91. PMID 17714448 DOI: 10.1111/J.1471-4159.2007.04860.X  0.638
2007 Vernon AC, Zbarsky V, Datla KP, Dexter DT, Croucher MJ. Selective activation of group III metabotropic glutamate receptors by L-(+)-2-amino-4-phosphonobutryic acid protects the nigrostriatal system against 6-hydroxydopamine toxicity in vivo. The Journal of Pharmacology and Experimental Therapeutics. 320: 397-409. PMID 17012606 DOI: 10.1124/Jpet.106.108159  0.605
2005 Zbarsky V, Datla KP, Parkar S, Rai DK, Aruoma OI, Dexter DT. Neuroprotective properties of the natural phenolic antioxidants curcumin and naringenin but not quercetin and fisetin in a 6-OHDA model of Parkinson's disease. Free Radical Research. 39: 1119-25. PMID 16298737 DOI: 10.1080/10715760500233113  0.313
2005 Vernon AC, Palmer S, Datla KP, Zbarsky V, Croucher MJ, Dexter DT. Neuroprotective effects of metabotropic glutamate receptor ligands in a 6-hydroxydopamine rodent model of Parkinson's disease. The European Journal of Neuroscience. 22: 1799-806. PMID 16197521 DOI: 10.1111/J.1460-9568.2005.04362.X  0.605
2004 Datla KP, Bennett RD, Zbarsky V, Ke B, Liang YF, Higa T, Bahorun T, Aruoma OI, Dexter DT. The antioxidant drink effective microorganism-X (EM-X) pre-treatment attenuates the loss of nigrostriatal dopaminergic neurons in 6-hydroxydopamine-lesion rat model of Parkinson's disease. The Journal of Pharmacy and Pharmacology. 56: 649-54. PMID 15142343 DOI: 10.1211/0022357023222  0.338
2003 Graeber MB, Dexter D, Pearce RK, Reynolds R. Parkinson's disease: an update. Neuropathology and Applied Neurobiology. 29: 514-5. PMID 14507344 DOI: 10.1046/J.1365-2990.2003.00461.X  0.342
2003 Datla KP, Murray HE, Pillai AV, Gillies GE, Dexter DT. Differences in dopaminergic neuroprotective effects of estrogen during estrous cycle. Neuroreport. 14: 47-50. PMID 12544829 DOI: 10.1097/00001756-200301200-00009  0.313
2001 Datla KP, Christidou M, Widmer WW, Rooprai HK, Dexter DT. Tissue distribution and neuroprotective effects of citrus flavonoid tangeretin in a rat model of Parkinson's disease. Neuroreport. 12: 3871-5. PMID 11726811 DOI: 10.1097/00001756-200112040-00053  0.378
2001 Datla KP, Blunt SB, Dexter DT. Chronic L-DOPA administration is not toxic to the remaining dopaminergic nigrostriatal neurons, but instead may promote their functional recovery, in rats with partial 6-OHDA or FeCl(3) nigrostriatal lesions. Movement Disorders : Official Journal of the Movement Disorder Society. 16: 424-34. PMID 11391735 DOI: 10.1002/Mds.1091  0.334
2001 Rooprai HK, Kandanearatchi A, Maidment SL, Christidou M, Trillo-Pazos G, Dexter DT, Rucklidge GJ, Widmer W, Pilkington GJ. Evaluation of the effects of swainsonine, captopril, tangeretin and nobiletin on the biological behaviour of brain tumour cells in vitro. Neuropathology and Applied Neurobiology. 27: 29-39. PMID 11299000 DOI: 10.1046/J.0305-1846.2000.00298.X  0.3
2000 Rooprai HK, Dexter DT, Thomson AD, Shaw K, Pratt OE. Regional distribution of transketolase in post-mortem human brain Neuroscience Research Communications. 26: 51-57. DOI: 10.1002/(Sici)1520-6769(200001/02)26:1<51::Aid-Nrc6>3.0.Co;2-A  0.31
1999 Fillebeen C, Mitchell V, Dexter D, Benaissa M, Beauvillain J, Spik G, Pierce A. Lactoferrin is synthesized by mouse brain tissue and its expression is enhanced after MPTP treatment. Brain Research. Molecular Brain Research. 72: 183-94. PMID 10529477 DOI: 10.1016/S0169-328X(99)00221-1  0.389
1998 Jeyasingham MD, Rooprai HK, Dexter D, Pratt OE, Komoly S. Zinc supplementation does not prevent cuprizone toxicity in the brain of mice Neuroscience Research Communications. 22: 181-187. DOI: 10.1002/(Sici)1520-6769(199805/06)22:3<181::Aid-Nrc7>3.0.Co;2-R  0.302
1994 Sian J, Dexter DT, Lees AJ, Daniel S, Jenner P, Marsden CD. Glutathione-related enzymes in brain in Parkinson's disease Annals of Neurology. 36: 356-361. PMID 8080243 DOI: 10.1002/Ana.410360306  0.311
Show low-probability matches.