Mario Jolicoeur - Publications

Affiliations: 
Ecole Polytechnique, Montreal (Canada) 
Area:
Chemical Engineering

78 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 da Veiga Moreira J, De Staercke L, César Martínez-Basilio P, Gauthier-Thibodeau S, Montégut L, Schwartz L, Jolicoeur M. Hyperosmolarity Triggers the Warburg Effect in Chinese Hamster Ovary Cells and Reveals a Reduced Mitochondria Horsepower. Metabolites. 11. PMID 34073567 DOI: 10.3390/metabo11060344  0.343
2020 Schwartz L, Peres S, Jolicoeur M, da Veiga Moreira J. Cancer and Alzheimer's disease: intracellular pH scales the metabolic disorders. Biogerontology. PMID 32617766 DOI: 10.1007/S10522-020-09888-6  0.337
2020 Bardyn M, Chen J, Dussiot M, Crettaz D, Schmid L, Längst E, Amireault P, Tissot JD, Jolicoeur M, Prudent M. Restoration of Physiological Levels of Uric Acid and Ascorbic Acid Reroutes the Metabolism of Stored Red Blood Cells. Metabolites. 10. PMID 32486030 DOI: 10.3390/Metabo10060226  0.368
2020 Montégut L, Martínez-Basilio PC, da Veiga Moreira J, Schwartz L, Jolicoeur M. Combining lipoic acid to methylene blue reduces the Warburg effect in CHO cells: From TCA cycle activation to enhancing monoclonal antibody production. Plos One. 15: e0231770. PMID 32298377 DOI: 10.1371/Journal.Pone.0231770  0.406
2020 Theiri M, Chadjaa H, Marinova M, Jolicoeur M. Development of sequential and simultaneous bacterial cultures to hydrolyse and detoxify wood pre-hydrolysate for enhanced acetone-butanol-ethanol (ABE) production. Enzyme and Microbial Technology. 133: 109438. PMID 31874697 DOI: 10.1016/J.Enzmictec.2019.109438  0.341
2019 Ren X, Deschênes JS, Tremblay R, Peres S, Jolicoeur M. A kinetic metabolic study of lipid production in Chlorella protothecoides under heterotrophic condition. Microbial Cell Factories. 18: 113. PMID 31253148 DOI: 10.1186/S12934-019-1163-4  0.414
2018 Theiri M, Chadjaa H, Marinova M, Jolicoeur M. Combining chemical flocculation and bacterial co-culture of Cupriavidus taiwanensis and Ureibacillus thermosphaericus to detoxify a hardwood hemicelluloses hydrolysate and enable ABE fermentation leading to butanol. Biotechnology Progress. PMID 30468318 DOI: 10.1002/Btpr.2753  0.307
2018 Laflaquière B, Leclercq G, Choey C, Chen J, Peres S, Ito C, Jolicoeur M. Identifying Biomarkers of Wharton's Jelly Mesenchymal Stromal Cells Using a Dynamic Metabolic Model: The Cell Passage Effect. Metabolites. 8. PMID 29495309 DOI: 10.3390/Metabo8010018  0.52
2017 Schwartz L, da Veiga Moreira J, Jolicoeur M. Physical forces modulate cell differentiation and proliferation processes. Journal of Cellular and Molecular Medicine. PMID 29193856 DOI: 10.1111/Jcmm.13417  0.373
2017 Zhao X, Kasbi M, Chen J, Peres S, Jolicoeur M. A dynamic metabolic flux analysis of ABE (acetone-butanol-ethanol) fermentation by Clostridium acetobutylicum ATCC 824, with riboflavin as a by-product. Biotechnology and Bioengineering. PMID 28853155 DOI: 10.1002/Bit.26393  0.412
2017 Goffaux G, Hammami I, Jolicoeur M. A Dynamic Metabolic Flux Analysis of Myeloid-Derived Suppressor Cells Confirms Immunosuppression-Related Metabolic Plasticity. Scientific Reports. 7: 9850. PMID 28852166 DOI: 10.1038/S41598-017-10464-1  0.794
2016 Zhao X, Condruz S, Chen J, Jolicoeur M. A quantitative metabolomics study of high sodium response in Clostridium acetobutylicum ATCC 824 acetone-butanol-ethanol (ABE) fermentation. Scientific Reports. 6: 28307. PMID 27321153 DOI: 10.1038/Srep28307  0.373
2016 Noel S, Fortier C, Murschel F, Belzil A, Gaudet G, Jolicoeur M, De Crescenzo G. Co-immobilization of adhesive peptides and VEGF within a dextran-based coating for vascular applications. Acta Biomaterialia. 37: 69-82. PMID 27039978 DOI: 10.1016/J.Actbio.2016.03.043  0.303
2016 Fernandes de Sousa S, Bastin G, Jolicoeur M, Vande Wouwer A. Dynamic metabolic flux analysis using a convex analysis approach: Application to hybridoma cell cultures in perfusion. Biotechnology and Bioengineering. 113: 1102-12. PMID 26551676 DOI: 10.1002/Bit.25879  0.405
2016 Fernandes S, Robitaille J, Bastin G, Jolicoeur M, Wouwer AV. Dynamic metabolic flux analysis of underdetermined and overdetermined metabolic networks Ifac-Papersonline. 49: 318-323. DOI: 10.1016/J.Ifacol.2016.12.146  0.35
2016 Fernandes S, Robitaille J, Bastin G, Jolicoeur M, Wouwer AV. Application of Dynamic Metabolic Flux Convex Analysis to CHO-DXB11 Cell Fed-batch Cultures Ifac-Papersonline. 49: 466-471. DOI: 10.1016/J.Ifacol.2016.07.386  0.414
2016 Ren X, Chen J, Deschênes JS, Tremblay R, Jolicoeur M. Glucose feeding recalibrates carbon flux distribution and favours lipid accumulation in Chlorella protothecoides through cell energetic management Algal Research. 14: 83-91. DOI: 10.1016/J.Algal.2016.01.004  0.431
2015 Robitaille J, Chen J, Jolicoeur M. A Single Dynamic Metabolic Model Can Describe mAb Producing CHO Cell Batch and Fed-Batch Cultures on Different Culture Media. Plos One. 10: e0136815. PMID 26331955 DOI: 10.1371/Journal.Pone.0136815  0.479
2014 Ghorbaniaghdam A, Henry O, Jolicoeur M. An in-silico study of the regulation of CHO cells glycolysis. Journal of Theoretical Biology. 357: 112-22. PMID 24801859 DOI: 10.1016/J.Jtbi.2014.04.035  0.471
2014 Sheikholeslami Z, Jolicoeur M, Henry O. Elucidating the effects of postinduction glutamine feeding on the growth and productivity of CHO cells. Biotechnology Progress. 30: 535-46. PMID 24692260 DOI: 10.1002/Btpr.1907  0.472
2014 Ghorbaniaghdam A, Chen J, Henry O, Jolicoeur M. Analyzing clonal variation of monoclonal antibody-producing CHO cell lines using an in silico metabolomic platform. Plos One. 9: e90832. PMID 24632968 DOI: 10.1371/Journal.Pone.0090832  0.475
2014 Binan L, Tendey C, De Crescenzo G, El Ayoubi R, Ajji A, Jolicoeur M. Differentiation of neuronal stem cells into motor neurons using electrospun poly-L-lactic acid/gelatin scaffold. Biomaterials. 35: 664-74. PMID 24161168 DOI: 10.1016/J.Biomaterials.2013.09.097  0.328
2013 Sheikholeslami Z, Jolicoeur M, Henry O. Probing the metabolism of an inducible mammalian expression system using extracellular isotopomer analysis. Journal of Biotechnology. 164: 469-78. PMID 23403402 DOI: 10.1016/J.Jbiotec.2013.01.025  0.427
2013 Claeyssen E, Dorion S, Clendenning A, He JZ, Wally O, Chen J, Auslender EL, Moisan MC, Jolicoeur M, Rivoal J. The futile cycling of hexose phosphates could account for the fact that hexokinase exerts a high control on glucose phosphorylation but not on glycolytic rate in transgenic potato (Solanum tuberosum) roots. Plos One. 8: e53898. PMID 23382859 DOI: 10.1371/Journal.Pone.0053898  0.386
2013 Hoemann CD, Guzmán-Morales J, Tran-Khanh N, Lavallée G, Jolicoeur M, Lavertu M. Chitosan rate of uptake in HEK293 cells is influenced by soluble versus microparticle state and enhanced by serum-induced cell metabolism and lactate-based media acidification. Molecules (Basel, Switzerland). 18: 1015-35. PMID 23322067 DOI: 10.3390/Molecules18011015  0.365
2013 Valancin A, Srinivasan B, Rivoal J, Jolicoeur M. Analyzing the effect of decreasing cytosolic triosephosphate isomerase on Solanum tuberosum hairy root cells using a kinetic-metabolic model. Biotechnology and Bioengineering. 110: 924-35. PMID 23055265 DOI: 10.1002/Bit.24747  0.473
2013 Ghorbaniaghdam A, Henry O, Jolicoeur M. A kinetic-metabolic model based on cell energetic state: study of CHO cell behavior under Na-butyrate stimulation. Bioprocess and Biosystems Engineering. 36: 469-87. PMID 22976819 DOI: 10.1007/S00449-012-0804-3  0.47
2013 Sheikholeslami Z, Jolicoeur M, Henry O. The impact of the timing of induction on the metabolism and productivity of CHO cells in culture Biochemical Engineering Journal. 79: 162-171. DOI: 10.1016/J.Bej.2013.07.015  0.517
2012 Hammami I, Chen J, Bronte V, DeCrescenzo G, Jolicoeur M. L-glutamine is a key parameter in the immunosuppression phenomenon. Biochemical and Biophysical Research Communications. 425: 724-9. PMID 22885179 DOI: 10.1016/J.Bbrc.2012.07.139  0.791
2012 Hammami I, Chen J, Murschel F, Bronte V, De Crescenzo G, Jolicoeur M. Immunosuppressive activity enhances central carbon metabolism and bioenergetics in myeloid-derived suppressor cells in vitro models. Bmc Cell Biology. 13: 18. PMID 22762146 DOI: 10.1186/1471-2121-13-18  0.793
2012 Hammami I, Bertrand M, Chen J, Bronte V, De Crescenzo G, Jolicoeur M. Nitric oxide affects immune cells bioenergetics: long-term effects of nitric-oxide derivatives on leukaemic Jurkat cell metabolism. Immunobiology. 217: 808-15. PMID 22656888 DOI: 10.1016/J.Imbio.2012.05.005  0.802
2011 Gigout A, Ruiz JC, Wertheimer MR, Jolicoeur M, Lerouge S. Nitrogen-rich plasma-polymerized coatings on PET and PTFE surfaces improve endothelial cell attachment and resistance to shear flow. Macromolecular Bioscience. 11: 1110-9. PMID 21591258 DOI: 10.1002/Mabi.201000512  0.305
2011 Mailier J, Delmotte A, Cloutier M, Jolicoeur M, Wouwer AV. Parametric sensitivity analysis and reduction of a detailed nutritional model of plant cell cultures. Biotechnology and Bioengineering. 108: 1108-1118. PMID 21287523 DOI: 10.1002/Bit.23030  0.377
2011 Hammami I, Chen J, Bronte V, De Crescenzo G, Jolicoeur M. Myeloid-derived suppressor cells exhibit two bioenergetic steady-states in vitro. Journal of Biotechnology. 152: 43-8. PMID 21262283 DOI: 10.1016/J.Jbiotec.2011.01.009  0.799
2011 Guzmán-Morales J, Ariganello MB, Hammami I, Thibault M, Jolicoeur M, Hoemann CD. Biodegradable chitosan particles induce chemokine release and negligible arginase-1 activity compared to IL-4 in murine bone marrow-derived macrophages. Biochemical and Biophysical Research Communications. 405: 538-44. PMID 21256824 DOI: 10.1016/J.Bbrc.2011.01.063  0.741
2011 Henry O, Jolicoeur M, Kamen A. Unraveling the metabolism of HEK-293 cells using lactate isotopomer analysis. Bioprocess and Biosystems Engineering. 34: 263-73. PMID 20848294 DOI: 10.1007/S00449-010-0468-9  0.46
2011 Mailier J, Delmotte A, Cloutier M, Jolicoeur M, VandeWouwer A. Sensitivity Analysis for Parameter Identification of a Plant Growth Model Ifac Proceedings Volumes. 44: 10615-10620. DOI: 10.3182/20110828-6-It-1002.00315  0.327
2010 Liberelle B, Boucher C, Chen J, Jolicoeur M, Durocher Y, De Crescenzo G. Impact of epidermal growth factor tethering strategy on cellular response. Bioconjugate Chemistry. 21: 2257-66. PMID 21058714 DOI: 10.1021/Bc1002604  0.362
2010 Boivin EB, Lepage E, Matton DP, De Crescenzo G, Jolicoeur M. Transient expression of antibodies in suspension plant cell suspension cultures is enhanced when co-transformed with the tomato bushy stunt virus p19 viral suppressor of gene silencing. Biotechnology Progress. 26: 1534-43. PMID 20859930 DOI: 10.1002/Btpr.485  0.341
2010 Boucher C, Ruiz JC, Thibault M, Buschmann MD, Wertheimer MR, Jolicoeur M, Durocher Y, De Crescenzo G. Human corneal epithelial cell response to epidermal growth factor tethered via coiled-coil interactions. Biomaterials. 31: 7021-31. PMID 20579729 DOI: 10.1016/J.Biomaterials.2010.05.072  0.352
2010 Ben-Tchavtchavadze M, Chen J, Perrier M, Jolicoeur M. A noninvasive technique for the measurement of the energetic state of free-suspension mammalian cells. Biotechnology Progress. 26: 532-41. PMID 19938168 DOI: 10.1002/Btpr.333  0.485
2010 Ghorbaniaghdam A, Henry O, Jolicoeur M. A kinetic modelling approach to study the role of energy regulatory pathways in CHO cells Ifac Proceedings Volumes (Ifac-Papersonline). 11: 479-484. DOI: 10.3182/20100707-3-Be-2012.0109  0.497
2010 Poliquin P, Cloutier M, Perrier M, Jolicoeur M. An approach for the study of energy regulated pathway in Parkinson's disease Ifac Proceedings Volumes. 43: 449-454. DOI: 10.3182/20100707-3-Be-2012.0105  0.311
2009 Cloutier M, Chen J, De Dobbeleer C, Perrier M, Jolicoeur M. A systems approach to plant bioprocess optimization. Plant Biotechnology Journal. 7: 939-51. PMID 19843248 DOI: 10.1111/J.1467-7652.2009.00455.X  0.47
2009 Gigout A, Levasseur S, Girard-Lauriault PL, Buschmann MD, Wertheimer MR, Jolicoeur M. CHO cells adhering to nitrogen-rich plasma-polymerised ethylene exhibit high production of a specific recombinant protein. Macromolecular Bioscience. 9: 979-88. PMID 19623580 DOI: 10.1002/Mabi.200900079  0.439
2009 McMurray-Beaulieu V, Hisiger S, Durand C, Perrier M, Jolicoeur M. Na-butyrate sustains energetic states of metabolism and t-PA productivity of CHO cells. Journal of Bioscience and Bioengineering. 108: 160-7. PMID 19619865 DOI: 10.1016/J.Jbiosc.2009.03.001  0.375
2009 Lioussanne L, Jolicoeur M, St-Arnaud M. Role of the modification in root exudation induced by arbuscular mycorrhizal colonization on the intraradical growth of Phytophthora nicotianae in tomato. Mycorrhiza. 19: 443-448. PMID 19488792 DOI: 10.1007/S00572-009-0257-Y  0.304
2009 Cloutier M, Chen J, Tatge F, McMurray-Beaulieu V, Perrier M, Jolicoeur M. Kinetic metabolic modelling for the control of plant cells cytoplasmic phosphate. Journal of Theoretical Biology. 259: 118-31. PMID 19281825 DOI: 10.1016/J.Jtbi.2009.02.022  0.445
2009 Gigout A, Buschmann MD, Jolicoeur M. Chondrocytes cultured in stirred suspension with serum-free medium containing pluronic-68 aggregate and proliferate while maintaining their differentiated phenotype. Tissue Engineering. Part A. 15: 2237-48. PMID 19231970 DOI: 10.1089/Ten.Tea.2008.0256  0.404
2008 Boucher C, St-Laurent G, Loignon M, Jolicoeur M, De Crescenzo G, Durocher Y. The bioactivity and receptor affinity of recombinant tagged EGF designed for tissue engineering applications is defined by the nature and position of the tags. Tissue Engineering. Part A. 14: 2069-77. PMID 18652537 DOI: 10.1089/Ten.Tea.2008.0037  0.345
2008 Generelli S, Jacquemart R, de Rooij NF, Jolicoeur M, Koudelka-Hep M, Guenat OT. Potentiometric platform for the quantification of cellular potassium efflux. Lab On a Chip. 8: 1210-5. PMID 18584100 DOI: 10.1039/B801042K  0.457
2008 Chavane N, Jacquemart R, Hoemann CD, Jolicoeur M, De Crescenzo G. At-line quantification of bioactive antibody in bioreactor by surface plasmon resonance using epitope detection. Analytical Biochemistry. 378: 158-65. PMID 18457651 DOI: 10.1016/J.Ab.2008.04.019  0.345
2008 Gigout A, Buschmann MD, Jolicoeur M. The fate of Pluronic F-68 in chondrocytes and CHO cells. Biotechnology and Bioengineering. 100: 975-87. PMID 18393312 DOI: 10.1002/Bit.21840  0.5
2008 Poulin F, Jacquemart R, De Crescenzo G, Jolicoeur M, Legros R. A Study of the interaction of HEK-293 cells with streamline chelating adsorbent in expanded bed operation. Biotechnology Progress. 24: 279-82. PMID 18197671 DOI: 10.1021/Bp070173T  0.322
2008 Cloutier M, Bouchard-Marchand É, Perrier M, Jolicoeur M. A predictive nutritional model for plant cells and hairy roots. Biotechnology and Bioengineering. 99: 189-200. PMID 17614323 DOI: 10.1002/Bit.21543  0.463
2008 Lioussanne L, Jolicoeur M, St-Arnaud M. Mycorrhizal colonization with Glomus intraradices and development stage of transformed tomato roots significantly modify the chemotactic response of zoospores of the pathogen Phytophthora nicotianae Soil Biology and Biochemistry. 40: 2217-2224. DOI: 10.1016/J.Soilbio.2008.04.013  0.311
2007 Cloutier M, Perrier M, Jolicoeur M. Dynamic flux cartography of hairy roots primary metabolism Phytochemistry. 68: 2393-2404. PMID 17555780 DOI: 10.1016/J.Phytochem.2007.04.028  0.448
2007 De Dobbeleer C, Cloutier M, Fouilland M, Legros R, Jolicoeur M. A high-rate perfusion bioreactor for plant cells. Biotechnology and Bioengineering. 95: 1126-37. PMID 16807927 DOI: 10.1002/Bit.21077  0.476
2007 Cloutier M, Jolicoeur M, Perrier M. Dynamic sensitivity analysis of Catharanthus roseus hairy roots metabolism Ifac Proceedings Volumes (Ifac-Papersonline). 10: 301-306. DOI: 10.3182/20070604-3-Mx-2914.00052  0.389
2006 Aucoin MG, McMurray-Beaulieu V, Poulin F, Boivin EB, Chen J, Ardelean FM, Cloutier M, Choi YJ, Miguez CB, Jolicoeur M. Identifying conditions for inducible protein production in E. coli: combining a fed-batch and multiple induction approach. Microbial Cell Factories. 5: 27. PMID 16911799 DOI: 10.1186/1475-2859-5-27  0.318
2006 Klvana M, Chen J, Lépine F, Legros R, Jolicoeur M. Analysis of secondary metabolites from eschscholtzia californica by high-performance liquid chromatography. Phytochemical Analysis : Pca. 17: 236-42. PMID 16910039 DOI: 10.1002/Pca.913  0.33
2006 Leduc M, Tikhomiroff C, Cloutier M, Perrier M, Jolicoeur M. Development of a kinetic metabolic model: application to Catharanthus roseus hairy root. Bioprocess and Biosystems Engineering. 28: 295-313. PMID 16453114 DOI: 10.1007/S00449-005-0034-Z  0.446
2005 Lamboursain L, Jolicoeur M. Critical influence of Eschscholzia californica cells nutritional state on secondary metabolite production. Biotechnology and Bioengineering. 91: 827-37. PMID 15948144 DOI: 10.1002/Bit.20553  0.769
2005 Hisiger S, Jolicoeur M. A multiwavelength fluorescence probe: is one probe capable for on-line monitoring of recombinant protein production and biomass activity? Journal of Biotechnology. 117: 325-36. PMID 15890426 DOI: 10.1016/J.Jbiotec.2005.03.004  0.384
2005 Hisiger S, Jolicoeur M. Plant cell culture monitoring using an in situ multiwavelength fluorescence probe. Biotechnology Progress. 21: 580-9. PMID 15801802 DOI: 10.1021/Bp049726F  0.367
2005 Lamboursain L, Jolicoeur M. Determination of cell concentration in a plant cell suspension using a fluorescence microplate reader. Plant Cell Reports. 23: 665-72. PMID 15747158 DOI: 10.1007/S00299-004-0899-3  0.757
2005 Klvana M, Legros R, Jolicoeur M. In situ extraction strategy affects benzophenanthridine alkaloid production fluxes in suspension cultures of Eschscholtzia californica. Biotechnology and Bioengineering. 89: 280-9. PMID 15744839 DOI: 10.1002/Bit.20306  0.441
2005 Gmati D, Chen J, Jolicoeur M. Development of a small-scale bioreactor: application to in vivo NMR measurement. Biotechnology and Bioengineering. 89: 138-47. PMID 15584028 DOI: 10.1002/Bit.20293  0.422
2003 Labour K, Jolicoeur M, St-Arnaud M. Arbuscular mycorrhizal responsiveness of in vitro tomato root lines is not related to growth and nutrient uptake rates Canadian Journal of Botany. 81: 645-656. DOI: 10.1139/B03-057  0.352
2002 Yuk IH, Wildt S, Jolicoeur M, Wang DI, Stephanopoulos G. A GFP-based screen for growth-arrested, recombinant protein-producing cells. Biotechnology and Bioengineering. 79: 74-82. PMID 17590933 DOI: 10.1002/Bit.10293  0.456
2002 Lamboursain L, St-Onge F, Jolicoeur M. A lab-built respirometer for plant and animal cell culture. Biotechnology Progress. 18: 1377-86. PMID 12467474 DOI: 10.1021/Bp015511J  0.746
2002 Tikhomiroff C, Jolicoeur M. Screening of Catharanthus roseus secondary metabolites by high-performance liquid chromatography. Journal of Chromatography. A. 955: 87-93. PMID 12061566 DOI: 10.1016/S0021-9673(02)00204-2  0.316
2002 Jolicoeur M, Bouchard-Marchand E, Bécard G, Perrier M. Regulation of mycorrhizal symbiosis: development of a structured nutritional dual model Ecological Modelling. 158: 121-142. DOI: 10.1016/S0304-3800(02)00168-0  0.355
2001 Tikhomiroff C, Lamboursain L, Jolicoeur M. Development of a Dual Biokinetic-Metabolic Model for Secondary Metabolites Production by Plant Cells Ifac Proceedings Volumes. 34: 373-378. DOI: 10.1016/S1474-6670(17)34248-9  0.762
1999 Jolicoeur M, Williams RD, Chavarie C, Fortin JA, Archambault J. Production of Glomus intraradices propagules, an arbuscular mycorrhizal fungus, in an airlift bioreactor Biotechnology and Bioengineering. 63: 224-232. PMID 10099599 DOI: 10.1002/(Sici)1097-0290(19990420)63:2<224::Aid-Bit11>3.0.Co;2-X  0.369
1995 Belfares L, Perrier M, Ramsay BA, Ramsay JA, Jolicoeur M, Chavarie C. Multi-inhibition kinetic model for the growth ofAlcaligenes eutrophus Canadian Journal of Microbiology. 41: 249-256. DOI: 10.1139/M95-193  0.322
1994 Bédard C, Jolicoeur M, Jardin B, Tom R, Perret S, Kamen A. Insect cell density in bioreactor cultures can be estimated from on-line measurements of optical density Biotechnology Techniques. 8: 605-610. DOI: 10.1007/Bf00241682  0.388
1992 Jolicoeur M, Chavarie C, Carreau PJ, Archambault J. Development of a helical-ribbon impeller bioreactor for high-density plant cell suspension culture. Biotechnology and Bioengineering. 39: 511-21. PMID 18600977 DOI: 10.1002/Bit.260390506  0.366
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