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Rekha C. Patel - Publications

Affiliations: 
Biological Sciences University of South Carolina, Columbia, SC 
Area:
Molecular Biology, Biochemistry, Genetics
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56 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Frederick K, Patel RC. Luteolin protects DYT- cells from apoptosis by suppressing PKR activation. Frontiers in Pharmacology. 14: 1118725. PMID 36874028 DOI: 10.3389/fphar.2023.1118725  0.526
2022 Vaughn LS, Frederick K, Burnett SB, Sharma N, Bragg DC, Camargos S, Cardoso F, Patel RC. DYT- Mutation P222L Enhances PACT's Stimulatory Activity on Type I Interferon Induction. Biomolecules. 12. PMID 35625640 DOI: 10.3390/biom12050713  0.394
2021 Ukhueduan B, Chukwurah E, Patel RC. Regulation of PKR activation and apoptosis during oxidative stress by TRBP phosphorylation. The International Journal of Biochemistry & Cell Biology. 137: 106030. PMID 34174402 DOI: 10.1016/j.biocel.2021.106030  0.547
2021 Vaughn LS, Chukwurah E, Patel RC. Opposite actions of two dsRNA-binding proteins PACT and TRBP on RIG-I mediated signaling. The Biochemical Journal. PMID 33459340 DOI: 10.1042/BCJ20200987  0.407
2020 Burnett SB, Vaughn LS, Sharma N, Kulkarni R, Patel RC. Dystonia 16 (DYT16) mutations in PACT cause dysregulated PKR activation and eIF2α signaling leading to a compromised stress response. Neurobiology of Disease. 146: 105135. PMID 33049316 DOI: 10.1016/j.nbd.2020.105135  0.501
2019 Burnett SB, Vaughn LS, Strom JM, Francois A, Patel RC. A truncated PACT protein resulting from a frameshift mutation reported in movement disorder DYT16 triggers caspase activation and apoptosis. Journal of Cellular Biochemistry. PMID 31246344 DOI: 10.1002/Jcb.29223  0.586
2019 Dey A, Patel R, Smalley T, Ratnayake WS, Islam A, Acevedo-Duncan M. Abstract 244: Inhibition of atypical PKC signaling enhances the sensitivity of glioblastoma cells towards Temozolomide therapy Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-244  0.324
2019 Smalley T, Patel R, Acevedo-Duncan M. Abstract 1776: An investigation of the effects of the atypical protein kinase C-ζinhibitor ζ-Stat on clear cell carcinoma ovarian cancer proliferation and invasion Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-1776  0.375
2018 Chukwurah E, Patel RC. Stress-induced TRBP phosphorylation enhances its interaction with PKR to regulate cellular survival. Scientific Reports. 8: 1020. PMID 29348664 DOI: 10.1038/S41598-018-19360-8  0.635
2018 Islam SMA, Khalid KM, Bommareddy RR, Patel R, Acevedo-Duncan M. Abstract 5155: The modulation of actin dynamics via atypical protein kinase-C activated cofilin regulates migration of colorectal cancer cells Tumor Biology. DOI: 10.1158/1538-7445.Am2018-5155  0.428
2018 Ratnayake WS, Apostolatos AH, Apostolatos CA, Dey A, Patel R, Acevedo-Duncan M. Abstract 2022: Oncogenic protein kinase Cι drives melanoma cell epithelial-mesenchymal transition by activating vimentin through Par6/RhoA signaling Tumor Biology. DOI: 10.1158/1538-7445.Am2018-2022  0.464
2017 Chukwurah E, Willingham V, Singh M, Castillo-Azofeifa D, Patel RC. Contribution of the two dsRBM motifs to the double-stranded RNA binding and protein interactions of PACT. Journal of Cellular Biochemistry. PMID 29231267 DOI: 10.1002/Jcb.26561  0.834
2017 Dabo S, Maillard P, Collados Rodriguez M, Hansen MD, Mazouz S, Bigot DJ, Tible M, Janvier G, Helynck O, Cassonnet P, Jacob Y, Bellalou J, Gatignol A, Patel RC, Hugon J, et al. Inhibition of the inflammatory response to stress by targeting interaction between PKR and its cellular activator PACT. Scientific Reports. 7: 16129. PMID 29170442 DOI: 10.1038/S41598-017-16089-8  0.462
2017 Chukwurah E, Handy I, Patel RC. ADAR1 and PACT contribute to efficient translation of transcripts containing HIV-1 trans-activating response (TAR) element. The Biochemical Journal. PMID 28167698 DOI: 10.1042/Bcj20160964  0.457
2016 Schumpert CA, Anderson C, Dudycha JL, Patel RC. Involvement of Daphnia pulicaria Sir2 in regulating stress response and lifespan. Aging. 8: 402-17. PMID 26978617  0.315
2015 Vaughn LS, Bragg DC, Sharma N, Camargos S, Cardoso F, Patel RC. Altered Activation of Protein Kinase PKR and Enhanced Apoptosis in Dystonia Cells Carrying a Mutation in PKR Activator Protein PACT. The Journal of Biological Chemistry. 290: 22543-57. PMID 26231208 DOI: 10.1074/Jbc.M115.669408  0.59
2015 Schumpert C, Nelson J, Kim E, Dudycha JL, Patel RC. Telomerase activity and telomere length in Daphnia. Plos One. 10: e0127196. PMID 25962144 DOI: 10.1371/Journal.Pone.0127196  0.315
2015 Chukwurah E, Radetskyy R, Daher A, Gatignol A, Patel RC. ID: 214 Cytokine. 76: 104. DOI: 10.1016/J.Cyto.2015.08.218  0.472
2015 Vaughn LS, Patel RC. ID: 104 Cytokine. 76: 84-85. DOI: 10.1016/J.Cyto.2015.08.131  0.477
2014 Schumpert C, Handy I, Dudycha JL, Patel RC. Relationship between heat shock protein 70 expression and life span in Daphnia. Mechanisms of Ageing and Development. 139: 1-10. PMID 24814302 DOI: 10.1016/J.Mad.2014.04.001  0.362
2014 Vaughn LS, Snee B, Patel RC. Inhibition of PKR protects against tunicamycin-induced apoptosis in neuroblastoma cells. Gene. 536: 90-6. PMID 24334130 DOI: 10.1016/J.Gene.2013.11.074  0.542
2013 Clerzius G, Shaw E, Daher A, Burugu S, Gélinas JF, Ear T, Sinck L, Routy JP, Mouland AJ, Patel RC, Gatignol A. The PKR activator, PACT, becomes a PKR inhibitor during HIV-1 replication. Retrovirology. 10: 96. PMID 24020926 DOI: 10.1186/1742-4690-10-96  0.499
2013 Patel R, Apostolatos A, Carter G, Ajmo J, Gali M, Cooper DR, You M, Bisht KS, Patel NA. Protein kinase C δ (PKCδ) splice variants modulate apoptosis pathway in 3T3L1 cells during adipogenesis: identification of PKCδII inhibitor. The Journal of Biological Chemistry. 288: 26834-46. PMID 23902767 DOI: 10.1074/Jbc.M113.482638  0.448
2013 Handy I, Patel RC. STAT1 requirement for PKR-induced cell cycle arrest in vascular smooth muscle cells in response to heparin. Gene. 524: 15-21. PMID 23597922 DOI: 10.1016/J.Gene.2013.03.124  0.567
2013 Clerzius G, Shaw E, Daher A, Burugu S, Gélinas J, Routy J, Patel RC, Gatignol A. HIV-1 replication changes the function of the PKR activator PACT Retrovirology. 10: P35. DOI: 10.1186/1742-4690-10-S1-P35  0.354
2013 Vaughn LS, Bragg DC, Sharma N, Camargos S, Cardoso F, Patel RC. 268 Cytokine. 63: 306-307. DOI: 10.1016/J.Cyto.2013.06.271  0.549
2012 Mittelstadt ML, Patel RC. AP-1 mediated transcriptional repression of matrix metalloproteinase-9 by recruitment of histone deacetylase 1 in response to interferon β. Plos One. 7: e42152. PMID 22879913 DOI: 10.1371/Journal.Pone.0042152  0.729
2012 Singh M, Patel RC. Increased interaction between PACT molecules in response to stress signals is required for PKR activation. Journal of Cellular Biochemistry. 113: 2754-64. PMID 22473766 DOI: 10.1002/Jcb.24152  0.834
2011 Singh M, Castillo D, Patel CV, Patel RC. Stress-induced phosphorylation of PACT reduces its interaction with TRBP and leads to PKR activation. Biochemistry. 50: 4550-60. PMID 21526770 DOI: 10.1021/Bi200104H  0.838
2011 Pillai P, Desai S, Patel R, Sajan M, Farese R, Ostrov D, Acevedo-Duncan M. A novel PKC-ι inhibitor abrogates cell proliferation and induces apoptosis in neuroblastoma. The International Journal of Biochemistry & Cell Biology. 43: 784-94. PMID 21315177 DOI: 10.1016/J.Biocel.2011.02.002  0.385
2011 Singh M, Handy I, Patel RC. PS2-065. Effect of DYT16 (PACT) mutations on interferon-induced protein kinase PKR and endoplasmic reticulum (ER) stress response pathway Cytokine. 56: 82. DOI: 10.1016/J.Cyto.2011.07.227  0.791
2010 Singh M, Castillo D, Patel CV, Patel RC. PS3-26 Phosphorylation of PACT at specific serines in response to stress signals regulates PKR activation by reducing PACT’s interaction with TRBP Cytokine. 52: 87. DOI: 10.1016/J.Cyto.2010.07.365  0.805
2009 Singh M, Fowlkes V, Handy I, Patel CV, Patel RC. Essential role of PACT-mediated PKR activation in tunicamycin-induced apoptosis. Journal of Molecular Biology. 385: 457-68. PMID 19007793 DOI: 10.1016/J.Jmb.2008.10.068  0.822
2009 Daher A, Laraki G, Singh M, Melendez-Peña CE, Bannwarth S, Peters AH, Meurs EF, Braun RE, Patel RC, Gatignol A. TRBP control of PACT-induced phosphorylation of protein kinase R is reversed by stress. Molecular and Cellular Biology. 29: 254-65. PMID 18936160 DOI: 10.1128/Mcb.01030-08  0.837
2008 Mittelstadt M, Frump A, Khuu T, Fowlkes V, Handy I, Patel CV, Patel RC. Interaction of human tRNA-dihydrouridine synthase-2 with interferon-induced protein kinase PKR. Nucleic Acids Research. 36: 998-1008. PMID 18096616 DOI: 10.1093/Nar/Gkm1129  0.81
2008 Trivedi CM, Patel RC, Patel CV. Differential regulation of HOXA9 expression by nuclear factor kappa B (NF-kappaB) and HOXA9. Gene. 408: 187-95. PMID 18068911 DOI: 10.1016/J.Gene.2007.11.001  0.695
2007 Trivedi CM, Patel RC, Patel CV. Homeobox gene HOXA9 inhibits nuclear factor-kappa B dependent activation of endothelium. Atherosclerosis. 195: e50-60. PMID 17586512 DOI: 10.1016/J.Atherosclerosis.2007.04.055  0.702
2007 Fasciano S, Kaufman A, Patel RC. Expression of PACT is regulated by Sp1 transcription factor. Gene. 388: 74-82. PMID 17125937 DOI: 10.1016/J.Gene.2006.10.003  0.779
2005 Fasciano S, Hutchins B, Handy I, Patel RC. Identification of the heparin-binding domains of the interferon-induced protein kinase, PKR. The Febs Journal. 272: 1425-39. PMID 15752359 DOI: 10.1111/J.1742-4658.2005.04575.X  0.788
2005 Fasciano S, Patel RC, Handy I, Patel CV. Regulation of vascular smooth muscle proliferation by heparin: inhibition of cyclin-dependent kinase 2 activity by p27(kip1). The Journal of Biological Chemistry. 280: 15682-9. PMID 15731113 DOI: 10.1074/Jbc.M411458200  0.755
2005 Bicaku E, Patel R, Acevedo-Duncan M. Cyclin-dependent kinase activating kinase/Cdk7 co-localizes with PKC-iota in human glioma cells. Tissue & Cell. 37: 53-8. PMID 15695176 DOI: 10.1016/J.Tice.2004.10.004  0.305
2004 Acevedo-Duncan M, Russell C, Patel S, Patel R. Aloe-emodin modulates PKC isozymes, inhibits proliferation, and induces apoptosis in U-373MG glioma cells. International Immunopharmacology. 4: 1775-84. PMID 15531293 DOI: 10.1016/J.Intimp.2004.07.012  0.301
2003 Gupta V, Huang X, Patel RC. The carboxy-terminal, M3 motifs of PACT and TRBP have opposite effects on PKR activity. Virology. 315: 283-91. PMID 14585331 DOI: 10.1016/S0042-6822(03)00589-0  0.679
2002 Patel RC, Handy I, Patel CV. Contribution of double-stranded RNA-activated protein kinase toward antiproliferative actions of heparin on vascular smooth muscle cells. Arteriosclerosis, Thrombosis, and Vascular Biology. 22: 1439-44. PMID 12231563 DOI: 10.1161/01.Atv.0000028817.20351.Fe  0.491
2002 Gupta V, Patel RC. Proapoptotic protein PACT is expressed at high levels in colonic epithelial cells in mice. American Journal of Physiology. Gastrointestinal and Liver Physiology. 283: G801-8. PMID 12181197 DOI: 10.1152/Ajpgi.00498.2001  0.599
2002 Huang X, Hutchins B, Patel RC. The C-terminal, third conserved motif of the protein activator PACT plays an essential role in the activation of double-stranded-RNA-dependent protein kinase (PKR). The Biochemical Journal. 366: 175-86. PMID 11985496 DOI: 10.1042/Bj20020204  0.691
2000 Edgerton M, Koshlukova SE, Araujo MWB, Patel RC, Dong J, Bruenn JA. Salivary histatin 5 and human neutrophil defensin 1 kill Candida albicans via shared pathways Antimicrobial Agents and Chemotherapy. 44: 3310-3316. PMID 11083633 DOI: 10.1128/Aac.44.12.3310-3316.2000  0.387
2000 Patel CV, Handy I, Goldsmith T, Patel RC. PACT, a stress-modulated cellular activator of interferon-induced double-stranded RNA-activated protein kinase, PKR Journal of Biological Chemistry. 275: 37993-37998. PMID 10988289 DOI: 10.1074/Jbc.M004762200  0.645
1999 Patel RC, Vestal DJ, Xu Z, Bandyopadhyay S, Guo W, Erme SM, Williams BR, Sen GC. DRBP76, a double-stranded RNA-binding nuclear protein, is phosphorylated by the interferon-induced protein kinase, PKR. The Journal of Biological Chemistry. 274: 20432-7. PMID 10400669 DOI: 10.1074/Jbc.274.29.20432  0.549
1998 Patel RC, Sen GC. Requirement of PKR dimerization mediated by specific hydrophobic residues for its activation by double-stranded RNA and its antigrowth effects in yeast Molecular and Cellular Biology. 18: 7009-7019. PMID 9819388 DOI: 10.1128/Mcb.18.12.7009  0.481
1998 Leaman DW, Salvekar A, Patel R, Sen GC, Stark GR. A mutant cell line defective in response to double-stranded RNA and in regulating basal expression of interferon-stimulated genes Proceedings of the National Academy of Sciences of the United States of America. 95: 9442-9447. PMID 9689099 DOI: 10.1073/Pnas.95.16.9442  0.5
1998 Patel RC, Sen GC. PACT, a protein activator of the interferon-induced protein kinase, PKR Embo Journal. 17: 4379-4390. PMID 9687506 DOI: 10.1093/Emboj/17.15.4379  0.589
1996 Patel RC, Stanton P, Sen GC. Specific mutations near the amino terminus of double-stranded RNA- dependent protein kinase (PKR) differentially affect its double-stranded RNA binding and dimerization properties Journal of Biological Chemistry. 271: 25657-25663. PMID 8810342 DOI: 10.1074/Jbc.271.41.25657  0.501
1995 Patel RC, Stanton P, Mcmillan NMJ, Williams BRG, Sen GC. The interferon-inducible double-stranded RNA-activated protein kinase self-associates in vitro and in vivo Proceedings of the National Academy of Sciences of the United States of America. 92: 8283-8287. PMID 7545299 DOI: 10.1073/Pnas.92.18.8283  0.576
1995 Desai SY, Patel RC, Sen GC, Malhotra P, Ghadge GD, Thimmapaya B. Activation of interferon-inducible 2′-5′ oligoadenylate synthetase by adenoviral VAI RNA Journal of Biological Chemistry. 270: 3454-3461. PMID 7531709 DOI: 10.1074/Jbc.270.7.3454  0.483
1992 Patel RC, Sen GC. Construction and expression of an enzymatically active human-mouse chimeric double-stranded RNA-dependent protein kinase Journal of Interferon Research. 12: 389-393. PMID 1358989 DOI: 10.1089/Jir.1992.12.389  0.504
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