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Yijun Huang, Ph.D. - Publications

Affiliations: 
2011 University of Pittsburgh, Pittsburgh, PA, United States 
Area:
Pharmacy, General Biophysics
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13 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Christner SM, Clausen DM, Beumer JH, Parise RA, Guo J, Huang Y, Dömling AS, Eiseman JL. In vitro cytotoxicity and in vivo efficacy, pharmacokinetics, and metabolism of pyrazole-based small molecule inhibitors of Mdm2/4-p53 interaction. Cancer Chemotherapy and Pharmacology. PMID 26050209 DOI: 10.1007/S00280-015-2791-Y  0.334
2014 Boltjes A, Huang Y, van de Velde R, Rijkee L, Wolf S, Gaugler J, Lesniak K, Guzik K, Holak TA, Dömling A. Fragment-based library generation for the discovery of a peptidomimetic p53-Mdm4 inhibitor. Acs Combinatorial Science. 16: 393-6. PMID 24983416 DOI: 10.1021/Co500026B  0.4
2014 Huang Y, Wolf S, Beck B, Köhler LM, Khoury K, Popowicz GM, Goda SK, Subklewe M, Twarda A, Holak TA, Dömling A. Discovery of highly potent p53-MDM2 antagonists and structural basis for anti-acute myeloid leukemia activities. Acs Chemical Biology. 9: 802-11. PMID 24405416 DOI: 10.1021/Cb400728E  0.387
2013 Bista M, Wolf S, Khoury K, Kowalska K, Huang Y, Wrona E, Arciniega M, Popowicz GM, Holak TA, Dömling A. Transient protein states in designing inhibitors of the MDM2-p53 interaction. Structure (London, England : 1993). 21: 2143-51. PMID 24207125 DOI: 10.1016/J.Str.2013.09.006  0.368
2012 Huang Y, Khoury K, Chanas T, Dömling A. Multicomponent synthesis of diverse 1,4-benzodiazepine scaffolds. Organic Letters. 14: 5916-9. PMID 23157402 DOI: 10.1021/Ol302837H  0.304
2012 Koes D, Khoury K, Huang Y, Wang W, Bista M, Popowicz GM, Wolf S, Holak TA, Dömling A, Camacho CJ. Enabling large-scale design, synthesis and validation of small molecule protein-protein antagonists. Plos One. 7: e32839. PMID 22427896 DOI: 10.1371/Journal.Pone.0032839  0.397
2012 Huang Y, Wolf S, Koes D, Popowicz GM, Camacho CJ, Holak TA, Dömling A. Exhaustive fluorine scanning toward potent p53-Mdm2 antagonists. Chemmedchem. 7: 49-52. PMID 21954050 DOI: 10.1002/Cmdc.201100428  0.371
2011 Huang Y, Dömling A. The Gewald multicomponent reaction. Molecular Diversity. 15: 3-33. PMID 20191319 DOI: 10.1007/S11030-010-9229-6  0.318
2010 Czarna A, Beck B, Srivastava S, Popowicz GM, Wolf S, Huang Y, Bista M, Holak TA, Dömling A. Robust generation of lead compounds for protein-protein interactions by computational and MCR chemistry: p53/Hdm2 antagonists. Angewandte Chemie (International Ed. in English). 49: 5352-6. PMID 20575124 DOI: 10.1002/Anie.201001343  0.387
2010 Huang Y, Dömling A. 1,4-Thienodiazepine-2,5-diones via MCR (II): scaffold hopping by Gewald and Ugi-deprotection-cyclization strategy. Chemical Biology & Drug Design. 76: 130-41. PMID 20545946 DOI: 10.1111/J.1747-0285.2010.00990.X  0.372
2010 Huang Y, Wolf S, Bista M, Meireles L, Camacho C, Holak TA, Dömling A. 1,4-Thienodiazepine-2,5-diones via MCR (I): synthesis, virtual space and p53-Mdm2 activity. Chemical Biology & Drug Design. 76: 116-29. PMID 20492448 DOI: 10.1111/J.1747-0285.2010.00989.X  0.41
2010 Dömling A, Huang Y. Piperazine scaffolds via isocyanide-based multicomponent reactions Synthesis. 2010: 2859-2883. DOI: 10.1055/S-0030-1257906  0.386
2009 Wang K, Nguyen K, Huang Y, Dömling A. Cyanoacetamide multicomponent reaction (I): Parallel synthesis of cyanoacetamides. Journal of Combinatorial Chemistry. 11: 920-7. PMID 19694451 DOI: 10.1021/Cc9000778  0.324
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