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Donna M. Huryn - Publications

Affiliations: 
Pharmacy University of Pittsburgh, Pittsburgh, PA, United States 
Area:
Drug Discovery and Medicinal Chemistry
Website:
http://webdev.chem.upenn.edu/chem/research/faculty.php?id=22
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38 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Cotticelli MG, Forestieri R, Xia S, Joyasawal S, Lee T, Xu K, Smith Iii AB, Huryn DM, Wilson RB. Identification of a Novel Oleic Acid Analog with Protective Effects in Multiple Cellular Models of Friedreich Ataxia. Acs Chemical Neuroscience. PMID 32786299 DOI: 10.1021/Acschemneuro.0C00323  0.376
2020 Loro E, Sengupta K, Bogdanovich S, Whig K, Schultz DC, Huryn DM, Khurana TS. High-throughput identification of post-transcriptional utrophin up-regulators for Duchenne muscle dystrophy (DMD) therapy. Scientific Reports. 10: 2132. PMID 32034254 DOI: 10.1038/S41598-020-58737-6  0.308
2019 Long K, Kostman SJ, Fernandez C, Burnett JC, Huryn DM. Do Zebrafish Obey Lipinski Rules? Acs Medicinal Chemistry Letters. 10: 1002-1006. PMID 31223462 DOI: 10.1021/Acsmedchemlett.9B00063  0.37
2018 LaPorte MG, Burnett JC, Colombo R, Bulfer SL, Alverez C, Chou TF, Neitz RJ, Green N, Moore WJ, Yue Z, Li S, Arkin MR, Wipf P, Huryn DM. Optimization of Phenyl Indole Inhibitors of the AAA+ ATPase p97. Acs Medicinal Chemistry Letters. 9: 1075-1081. PMID 30429948 DOI: 10.1021/Acsmedchemlett.8B00372  0.361
2016 LaPorte MG, Wang Z, Colombo R, Garzan A, Peshkov VA, Liang M, Johnston PA, Schurdak ME, Sen M, Camarco DP, Hua Y, Pollock NI, Lazo JS, Grandis JR, Wipf P, ... Huryn DM, et al. Optimization of pyrazole-containing 1,2,4-triazolo-[3,4-b]thiadiazines, a new class of STAT3 pathway inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 27381083 DOI: 10.1016/J.Bmcl.2016.06.017  0.374
2016 Johnston PA, Nguyen MM, Dar JA, Ai J, Wang Y, Masoodi KZ, Shun T, Shinde S, Camarco DP, Hua Y, Huryn DM, Wilson GM, Lazo JS, Nelson JB, Wipf P, et al. Development and Implementation of a High-Throughput High-Content Screening Assay to Identify Inhibitors of Androgen Receptor Nuclear Localization in Castration-Resistant Prostate Cancer Cells. Assay and Drug Development Technologies. 14: 226-39. PMID 27187604 DOI: 10.1089/Adt.2016.716  0.307
2016 Alverez C, Bulfer SL, Chakrasali R, Chimenti MS, Deshaies RJ, Green N, Kelly M, LaPorte MG, Lewis TS, Liang M, Moore WJ, Neitz RJ, Peshkov VA, Walters MA, Zhang F, ... ... Huryn DM, et al. Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway. Acs Medicinal Chemistry Letters. 7: 182-7. PMID 26985295 DOI: 10.1021/Acsmedchemlett.5B00396  0.387
2016 Lassalas P, Gay B, Lasfargeas C, James MJ, Tran V, Vijayendran KG, Brunden KR, Kozlowski MC, Thomas CJ, Smith Iii AB, Huryn DM, Ballatore C. Structure Property Relationships of Carboxylic Acid Isosteres. Journal of Medicinal Chemistry. PMID 26967507 DOI: 10.1021/Acs.Jmedchem.5B01963  0.685
2015 Alverez C, Arkin MR, Bulfer SL, Colombo R, Kovaliov M, LaPorte MG, Lim C, Liang M, Moore WJ, Neitz RJ, Yan Y, Yue Z, Huryn DM, Wipf P. Structure-Activity Study of Bioisosteric Trifluoromethyl and Pentafluorosulfanyl Indole Inhibitors of the AAA ATPase p97. Acs Medicinal Chemistry Letters. 6: 1225-30. PMID 26713109 DOI: 10.1021/Acsmedchemlett.5B00364  0.337
2015 Johnston PA, Sen M, Hua Y, Camarco DP, Shun TY, Lazo JS, Wilson GM, Resnick LO, LaPorte MG, Wipf P, Huryn DM, Grandis JR. HCS Campaign to Identify Selective Inhibitors of IL-6-Induced STAT3 Pathway Activation in Head and Neck Cancer Cell Lines. Assay and Drug Development Technologies. 13: 356-76. PMID 26317883 DOI: 10.1089/Adt.2015.663  0.351
2015 Maryanoff BE, Huryn DM. Our scope expansion to include biologics. Acs Medicinal Chemistry Letters. 6: 227. PMID 25941543 DOI: 10.1021/Acsmedchemlett.5B00063  0.328
2014 LaPorte MG, da Paz Lima DJ, Zhang F, Sen M, Grandis JR, Camarco D, Hua Y, Johnston PA, Lazo JS, Resnick LO, Wipf P, Huryn DM. 2-Guanidinoquinazolines as new inhibitors of the STAT3 pathway. Bioorganic & Medicinal Chemistry Letters. 24: 5081-5. PMID 25288188 DOI: 10.1016/J.Bmcl.2014.09.001  0.348
2014 Colombo R, Jeon KO, Huryn DM, LaPorte MG, Wipf P. A new synthesis of 4,5,6,7-Tetrahydropyrazolo[1,5-c] pyrimidines by a retro-mannich cascade rearrangement Australian Journal of Chemistry. 67: 420-425. DOI: 10.1071/Ch13468  0.301
2013 Ballatore C, Huryn DM, Smith AB. Carboxylic acid (bio)isosteres in drug design. Chemmedchem. 8: 385-95. PMID 23361977 DOI: 10.1002/Cmdc.201200585  0.435
2012 Culyba M, Hwang Y, Attar S, Madrid PB, Bupp J, Huryn D, Sanchez L, Grobler J, Miller MD, Bushman FD. Bulged DNA substrates for identifying poxvirus resolvase inhibitors. Nucleic Acids Research. 40: e124. PMID 22581770 DOI: 10.1093/Nar/Gks325  0.509
2011 Ballatore C, Soper JH, Piscitelli F, James M, Huang L, Atasoylu O, Huryn DM, Trojanowski JQ, Lee VM, Brunden KR, Smith AB. Cyclopentane-1,3-dione: a novel isostere for the carboxylic acid functional group. Application to the design of potent thromboxane (A2) receptor antagonists. Journal of Medicinal Chemistry. 54: 6969-83. PMID 21863799 DOI: 10.1021/Jm200980U  0.704
2011 Huryn DM, Brodsky JL, Brummond KM, Chambers PG, Eyer B, Ireland AW, Kawasumi M, Laporte MG, Lloyd K, Manteau B, Nghiem P, Quade B, Seguin SP, Wipf P. Chemical methodology as a source of small-molecule checkpoint inhibitors and heat shock protein 70 (Hsp70) modulators. Proceedings of the National Academy of Sciences of the United States of America. 108: 6757-62. PMID 21502524 DOI: 10.1073/Pnas.1015251108  0.37
2010 Clifton JD, Lucumi E, Myers MC, Napper A, Hama K, Farber SA, Smith AB, Huryn DM, Diamond SL, Pack M. Identification of novel inhibitors of dietary lipid absorption using zebrafish. Plos One. 5: e12386. PMID 20811635 DOI: 10.1371/Journal.Pone.0012386  0.335
2010 Liu Z, Myers MC, Shah PP, Beavers MP, Benedetti PA, Diamond SL, Smith AB, Huryn DM. Design, synthesis and biological evaluation of a library of thiocarbazates and their activity as cysteine protease inhibitors. Combinatorial Chemistry & High Throughput Screening. 13: 337-51. PMID 20438448 DOI: 10.2174/138620710791054303  0.376
2009 Crowe A, Huang W, Ballatore C, Johnson RL, Hogan AM, Huang R, Wichterman J, McCoy J, Huryn D, Auld DS, Smith AB, Inglese J, Trojanowski JQ, Austin CP, Brunden KR, et al. Identification of aminothienopyridazine inhibitors of tau assembly by quantitative high-throughput screening. Biochemistry. 48: 7732-45. PMID 19580328 DOI: 10.1021/Bi9006435  0.32
2009 Pu J, Kreft AF, Aschmies SH, Atchison KP, Berkowitz J, Caggiano TJ, Chlenov M, Diamantidis G, Harrison BL, Hu Y, Huryn D, Steven Jacobsen J, Jin M, Lipinski K, Lu P, et al. Synthesis and structure-activity relationship of a novel series of heterocyclic sulfonamide gamma-secretase inhibitors. Bioorganic & Medicinal Chemistry. 17: 4708-17. PMID 19443228 DOI: 10.1016/J.Bmc.2009.04.052  0.327
2009 Chiang AN, Valderramos JC, Balachandran R, Chovatiya RJ, Mead BP, Schneider C, Bell SL, Klein MG, Huryn DM, Chen XS, Day BW, Fidock DA, Wipf P, Brodsky JL. Select pyrimidinones inhibit the propagation of the malarial parasite, Plasmodium falciparum. Bioorganic & Medicinal Chemistry. 17: 1527-33. PMID 19195901 DOI: 10.1016/J.Bmc.2009.01.024  0.3
2008 Beavers MP, Myers MC, Shah PP, Purvis JE, Diamond SL, Cooperman BS, Huryn DM, Smith AB. Molecular docking of cathepsin L inhibitors in the binding site of papain. Journal of Chemical Information and Modeling. 48: 1464-72. PMID 18598021 DOI: 10.1021/Ci800085C  0.336
2008 Kreft A, Harrison B, Aschmies S, Atchison K, Casebier D, Cole DC, Diamantidis G, Ellingboe J, Hauze D, Hu Y, Huryn D, Jin M, Kubrak D, Lu P, Lundquist J, et al. Discovery of a novel series of Notch-sparing gamma-secretase inhibitors. Bioorganic & Medicinal Chemistry Letters. 18: 4232-6. PMID 18556202 DOI: 10.1016/J.Bmcl.2008.05.064  0.332
2008 Myers MC, Shah PP, Beavers MP, Napper AD, Diamond SL, Smith AB, Huryn DM. Design, synthesis, and evaluation of inhibitors of cathepsin L: Exploiting a unique thiocarbazate chemotype. Bioorganic & Medicinal Chemistry Letters. 18: 3646-51. PMID 18499453 DOI: 10.1016/J.Bmcl.2008.04.065  0.337
2008 Shah PP, Myers MC, Beavers MP, Purvis JE, Jing H, Grieser HJ, Sharlow ER, Napper AD, Huryn DM, Cooperman BS, Smith AB, Diamond SL. Kinetic characterization and molecular docking of a novel, potent, and selective slow-binding inhibitor of human cathepsin L. Molecular Pharmacology. 74: 34-41. PMID 18403718 DOI: 10.1124/Mol.108.046219  0.333
2008 Myers MC, Shah PP, Diamond SL, Huryn DM, Smith AB. Identification and synthesis of a unique thiocarbazate cathepsin L inhibitor. Bioorganic & Medicinal Chemistry Letters. 18: 210-4. PMID 18060772 DOI: 10.1016/J.Bmcl.2007.10.107  0.351
2007 Huryn DM, Cosford NDP. Chapter 26 The Molecular Libraries Screening Center Network (MLSCN): Identifying Chemical Probes of Biological Systems. Annual Reports in Medicinal Chemistry. 42: 401-416. PMID 32287469 DOI: 10.1016/S0065-7743(07)42026-7  0.33
2007 Johnston PA, Phillips J, Shun TY, Shinde S, Lazo JS, Huryn DM, Myers MC, Ratnikov BI, Smith JW, Su Y, Dahl R, Cosford ND, Shiryaev SA, Strongin AY. HTS identifies novel and specific uncompetitive inhibitors of the two-component NS2B-NS3 proteinase of West Nile virus. Assay and Drug Development Technologies. 5: 737-50. PMID 18181690 DOI: 10.1089/Adt.2007.101  0.342
2007 Myers MC, Napper AD, Motlekar N, Shah PP, Chiu CH, Beavers MP, Diamond SL, Huryn DM, Smith AB. Identification and characterization of 3-substituted pyrazolyl esters as alternate substrates for cathepsin B: the confounding effects of DTT and cysteine in biological assays. Bioorganic & Medicinal Chemistry Letters. 17: 4761-6. PMID 17656088 DOI: 10.1016/J.Bmcl.2007.06.091  0.378
2006 Hatzenbuhler NT, Evrard DA, Harrison BL, Huryn D, Inghrim J, Kraml C, Mattes JF, Mewshaw RE, Zhou D, Hornby G, Lin Q, Smith DL, Sullivan KM, Schechter LE, Beyer CE, et al. Synthesis and biological evaluation of novel compounds within a class of 3-aminochroman derivatives with dual 5-HT1A receptor and serotonin transporter affinity. Journal of Medicinal Chemistry. 49: 4785-9. PMID 16854086 DOI: 10.1021/Jm060218H  0.352
2006 Harrison BL, Kreft A, Aschmies S, Atchison K, Cole D, Ellingboe J, Hauze D, Hu Y, Huryn D, Jin M, Kubrak D, Lu P, Mann C, Martone R, Moore W, et al. P4-244: Discovery of a novel series of notch-sparing γ-secretase inhibitors Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.1984  0.315
2005 Childers WE, Abou-Gharbia MA, Kelly MG, Andree TH, Harrison BL, Ho DM, Hornby G, Huryn DM, Potestio L, Rosenzweig-Lipson SJ, Schmid J, Smith DL, Sukoff SJ, Zhang G, Schechter LE. Synthesis and biological evaluation of benzodioxanylpiperazine derivatives as potent serotonin 5-HT(1A) antagonists: the discovery of Lecozotan. Journal of Medicinal Chemistry. 48: 3467-70. PMID 15887953 DOI: 10.1021/Jm049493Z  0.371
2004 Huryn DM, Konradi AW, Ashwell S, Freedman SB, Lombardo LJ, Pleiss MA, Thorsett ED, Yednock T, Kennedy JD. The identification and optimization of orally efficacious, small molecule VLA-4 antagonists. Current Topics in Medicinal Chemistry. 4: 1473-84. PMID 15544538 DOI: 10.2174/1568026043387467  0.317
2004 Huryn DM, Ashwell S, Baudy R, Dressen DB, Gallaway W, Grant FS, Konradi A, Ley RW, Petusky S, Pleiss MA, Sarantakis D, Semko CM, Sherman MM, Tio C, Zhang L. Synthesis, characterization and evaluation of pro-drugs of VLA-4 antagonists. Bioorganic & Medicinal Chemistry Letters. 14: 1651-4. PMID 15026043 DOI: 10.1016/J.Bmcl.2004.01.062  0.326
1996 Liu A, Dillon K, Campbell RM, Cox DC, Huryn DM. Synthesis of E-selectin inhibitors: Use of an aryl-cyclohexyl ether as a disaccharide scaffold Tetrahedron Letters. 37: 3785-3788. DOI: 10.1016/0040-4039(96)00713-7  0.371
1992 Huryn DM, Sluboski BC, Tam SY, Weigele M, Sim I, Anderson BD, Mitsuya H, Broder S. Synthesis and anti-HIV activity of isonucleosides. Journal of Medicinal Chemistry. 35: 2347-54. PMID 1619614 DOI: 10.1021/Jm00091A001  0.317
1989 Huryn DM, Sluboski BC, Tam SY, Todaro LJ, Weigele M. Synthesis of iso-ddA, member of a novel class of anti-HIV agents Tetrahedron Letters. 30: 6259-6262. DOI: 10.1016/S0040-4039(01)93867-5  0.33
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