Narasimhan Gautam, Ph.D. - Publications

Affiliations: 
Anesthesiology Washington University Medical School 
Area:
G-proteins

65 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Meshik X, O'Neill PR, Gautam N. Optogenetic Control of Cell Migration. Methods in Molecular Biology (Clifton, N.J.). 1749: 313-324. PMID 29526006 DOI: 10.1007/978-1-4939-7701-7_22  0.419
2016 O'Neill PR, Kalyanaraman V, Gautam N. Subcellular optogenetic activation of Cdc42 controls local and distal signaling to drive immune cell migration. Molecular Biology of the Cell. PMID 26941336 DOI: 10.1091/Mbc.E15-12-0832  0.327
2015 O'Neill PR, Gautam N. Optimizing optogenetic constructs for control over signaling and cell behaviours. Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society For Photobiology. 14: 1578-85. PMID 26135203 DOI: 10.1039/C5Pp00171D  0.324
2015 Karunarathne WK, O'Neill PR, Gautam N. Subcellular optogenetics - controlling signaling and single-cell behavior. Journal of Cell Science. 128: 15-25. PMID 25433038 DOI: 10.1242/Jcs.154435  0.383
2014 Giri L, Patel AK, Karunarathne WK, Kalyanaraman V, Venkatesh KV, Gautam N. A G-protein subunit translocation embedded network motif underlies GPCR regulation of calcium oscillations. Biophysical Journal. 107: 242-54. PMID 24988358 DOI: 10.1016/J.Bpj.2014.05.020  0.465
2014 O'Neill PR, Gautam N. Subcellular optogenetic inhibition of G proteins generates signaling gradients and cell migration. Molecular Biology of the Cell. 25: 2305-14. PMID 24920824 DOI: 10.1091/Mbc.E14-04-0870  0.503
2014 O'Neill PR, Giri L, Karunarathne WK, Patel AK, Venkatesh KV, Gautam N. The structure of dynamic GPCR signaling networks. Wiley Interdisciplinary Reviews. Systems Biology and Medicine. 6: 115-23. PMID 24741711 DOI: 10.1002/Wsbm.1249  0.314
2013 Karunarathne WK, Giri L, Patel AK, Venkatesh KV, Gautam N. Optical control demonstrates switch-like PIP3 dynamics underlying the initiation of immune cell migration. Proceedings of the National Academy of Sciences of the United States of America. 110: E1575-83. PMID 23569254 DOI: 10.1073/Pnas.1220755110  0.338
2013 Karunarathne WK, Giri L, Kalyanaraman V, Gautam N. Optically triggering spatiotemporally confined GPCR activity in a cell and programming neurite initiation and extension. Proceedings of the National Academy of Sciences of the United States of America. 110: E1565-74. PMID 23479634 DOI: 10.1073/Pnas.1220697110  0.331
2012 O'Neill PR, Karunarathne WK, Kalyanaraman V, Silvius JR, Gautam N. G-protein signaling leverages subunit-dependent membrane affinity to differentially control βγ translocation to intracellular membranes. Proceedings of the National Academy of Sciences of the United States of America. 109: E3568-77. PMID 23213235 DOI: 10.1073/Pnas.1205345109  0.492
2012 Ajith Karunarathne WK, O'Neill PR, Martinez-Espinosa PL, Kalyanaraman V, Gautam N. All G protein βγ complexes are capable of translocation on receptor activation. Biochemical and Biophysical Research Communications. 421: 605-11. PMID 22538369 DOI: 10.1016/J.Bbrc.2012.04.054  0.563
2012 Gautam N. Real time analysis of protein location and function: a Golgi-specific PKD sensor. Biotechnology Journal. 7: 17-8. PMID 22057971 DOI: 10.1002/Biot.201100424  0.301
2011 Cho JH, Saini DK, Karunarathne WK, Kalyanaraman V, Gautam N. Alteration of Golgi structure in senescent cells and its regulation by a G protein γ subunit. Cellular Signalling. 23: 785-93. PMID 21238584 DOI: 10.1016/J.Cellsig.2011.01.001  0.522
2010 Saini DK, Karunarathne WK, Angaswamy N, Saini D, Cho JH, Kalyanaraman V, Gautam N. Regulation of Golgi structure and secretion by receptor-induced G protein βγ complex translocation. Proceedings of the National Academy of Sciences of the United States of America. 107: 11417-22. PMID 20534534 DOI: 10.1073/pnas.1003042107  0.397
2010 Saini DK, Gautam N. Live cell imaging for studying g protein-coupled receptor activation in single cells. Methods in Molecular Biology (Clifton, N.J.). 617: 191-207. PMID 20336424 DOI: 10.1007/978-1-60327-323-7_16  0.475
2009 Chisari M, Saini DK, Cho JH, Kalyanaraman V, Gautam N. G protein subunit dissociation and translocation regulate cellular response to receptor stimulation. Plos One. 4: e7797. PMID 19936219 DOI: 10.1371/Journal.Pone.0007797  0.536
2009 Saini DK, Chisari M, Gautam N. Shuttling and translocation of heterotrimeric G proteins and Ras. Trends in Pharmacological Sciences. 30: 278-86. PMID 19427041 DOI: 10.1016/J.Tips.2009.04.001  0.465
2007 Saini DK, Kalyanaraman V, Chisari M, Gautam N. A family of G protein βγ subunits translocate reversibly from the plasma membrane to endomembranes on receptor activation. The Journal of Biological Chemistry. 282: 24099-108. PMID 17581822 DOI: 10.1074/Jbc.M701191200  0.606
2007 Chisari M, Saini DK, Kalyanaraman V, Gautam N. Shuttling of G protein subunits between the plasma membrane and intracellular membranes. The Journal of Biological Chemistry. 282: 24092-8. PMID 17576765 DOI: 10.1074/Jbc.M704246200  0.478
2006 Akgoz M, Kalyanaraman V, Gautam N. G protein betagamma complex translocation from plasma membrane to Golgi complex is influenced by receptor gamma subunit interaction. Cellular Signalling. 18: 1758-68. PMID 16517125 DOI: 10.1016/J.Cellsig.2006.01.016  0.553
2006 Azpiazu I, Gautam N. A G protein gamma subunit peptide stabilizes a novel muscarinic receptor state. Biochemical and Biophysical Research Communications. 341: 904-10. PMID 16466691 DOI: 10.1016/J.Bbrc.2006.01.093  0.427
2006 Azpiazu I, Akgoz M, Kalyanaraman V, Gautam N. G protein betagamma11 complex translocation is induced by Gi, Gq and Gs coupling receptors and is regulated by the alpha subunit type. Cellular Signalling. 18: 1190-200. PMID 16242307 DOI: 10.1016/J.Cellsig.2005.09.007  0.538
2004 Akgoz M, Kalyanaraman V, Gautam N. Receptor-mediated reversible translocation of the G protein betagamma complex from the plasma membrane to the Golgi complex. The Journal of Biological Chemistry. 279: 51541-4. PMID 15448129 DOI: 10.1074/Jbc.M410639200  0.517
2004 Azpiazu I, Gautam N. A fluorescence resonance energy transfer-based sensor indicates that receptor access to a G protein is unrestricted in a living mammalian cell. The Journal of Biological Chemistry. 279: 27709-18. PMID 15078878 DOI: 10.1074/Jbc.M403712200  0.453
2003 Gautam N. A conformational switch regulates receptor-G protein interaction. Structure (London, England : 1993). 11: 359-60. PMID 12679009 DOI: 10.1016/S0969-2126(03)00054-6  0.515
2002 Akgoz M, Azpiazu I, Kalyanaraman V, Gautam N. Role of the G protein gamma subunit in beta gamma complex modulation of phospholipase Cbeta function. The Journal of Biological Chemistry. 277: 19573-8. PMID 11914377 DOI: 10.1074/Jbc.M201546200  0.516
2002 Hou Y, Chang V, Gautam N. Determining G protein heterotrimer formation. Methods in Enzymology. 344: 505-12. PMID 11771406 DOI: 10.1016/S0076-6879(02)44736-2  0.511
2002 Kale TA, Turek TC, Chang V, Gautam N, Distefano MD. Preparation and application of G protein gamma subunit-derived peptides incorporating a photoactive isoprenoid. Methods in Enzymology. 344: 245-58. PMID 11771387 DOI: 10.1016/S0076-6879(02)44719-2  0.49
2002 Azpiazu I, Gautam N. Role of G protein beta gamma complex in receptor-G protein interaction. Methods in Enzymology. 344: 112-25. PMID 11771376 DOI: 10.1016/S0076-6879(02)44709-X  0.579
2001 Fogg VC, Azpiazu I, Linder ME, Smrcka A, Scarlata S, Gautam N. Role of the gamma subunit prenyl moiety in G protein beta gamma complex interaction with phospholipase Cbeta. The Journal of Biological Chemistry. 276: 41797-802. PMID 11546822 DOI: 10.1074/Jbc.M107661200  0.5
2001 Azpiazu I, Gautam N. G protein gamma subunit interaction with a receptor regulates receptor-stimulated nucleotide exchange. The Journal of Biological Chemistry. 276: 41742-7. PMID 11546799 DOI: 10.1074/Jbc.M104034200  0.582
2001 Hou Y, Chang V, Capper AB, Taussig R, Gautam N. G Protein beta subunit types differentially interact with a muscarinic receptor but not adenylyl cyclase type II or phospholipase C-beta 2/3. The Journal of Biological Chemistry. 276: 19982-8. PMID 11262394 DOI: 10.1074/Jbc.M010424200  0.473
2000 Hou Y, Azpiazu I, Smrcka A, Gautam N. Selective role of G protein gamma subunits in receptor interaction. The Journal of Biological Chemistry. 275: 38961-4. PMID 11042163 DOI: 10.1074/Jbc.C000604200  0.563
1999 Downes GB, Gautam N. The G protein subunit gene families. Genomics. 62: 544-52. PMID 10644457 DOI: 10.1006/Geno.1999.5992  0.767
1999 Azpiazu I, Cruzblanca H, Li P, Linder M, Zhuo M, Gautam N. A G protein gamma subunit-specific peptide inhibits muscarinic receptor signaling. The Journal of Biological Chemistry. 274: 35305-8. PMID 10585394 DOI: 10.1074/Jbc.274.50.35305  0.48
1999 Downes GB, Gilbert DJ, Copeland NG, Gautam N, Jenkins NA. Chromosomal mapping of five mouse G protein gamma subunits. Genomics. 57: 173-6. PMID 10191100 DOI: 10.1006/Geno.1999.5763  0.769
1999 Bell B, Xing H, Yan K, Gautam N, Muslin AJ. KSR-1 binds to G-protein betagamma subunits and inhibits beta gamma-induced mitogen-activated protein kinase activation. The Journal of Biological Chemistry. 274: 7982-6. PMID 10075696 DOI: 10.1074/Jbc.274.12.7982  0.506
1998 García DE, Li B, García-Ferreiro RE, Hernández-Ochoa EO, Yan K, Gautam N, Catterall WA, Mackie K, Hille B. G-protein beta-subunit specificity in the fast membrane-delimited inhibition of Ca2+ channels. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 9163-70. PMID 9801356  0.361
1998 Downes GB, Copeland NG, Jenkins NA, Gautam N. Structure and mapping of the G protein gamma3 subunit gene and a divergently transcribed novel gene, gng3lg. Genomics. 53: 220-30. PMID 9790771 DOI: 10.1006/Geno.1998.5508  0.746
1998 Gautam N, Downes GB, Yan K, Kisselev O. The G-protein betagamma complex. Cellular Signalling. 10: 447-55. PMID 9754712 DOI: 10.1016/S0898-6568(98)00006-0  0.781
1998 Kalyanaraman S, Copeland NG, Gilbert DG, Jenkins NA, Gautam N. Structure and chromosomal localization of mouse G protein subunit gamma 4 gene. Genomics. 49: 147-51. PMID 9570961 DOI: 10.1006/Geno.1998.5223  0.548
1998 Kisselev OG, Kao J, Ponder JW, Fann YC, Gautam N, Marshall GR. Light-activated rhodopsin induces structural binding motif in G protein alpha subunit. Proceedings of the National Academy of Sciences of the United States of America. 95: 4270-5. PMID 9539726 DOI: 10.1073/Pnas.95.8.4270  0.511
1998 Garcı́a DE, Li B, Garcı́a-Ferreiro RE, Hernández-Ochoa EO, Yan K, Gautam N, Catterall WA, Mackie K, Hille B. G-Protein β-Subunit Specificity in the Fast Membrane-Delimited Inhibition of Ca2+ Channels The Journal of Neuroscience. 18: 9163-9170. DOI: 10.1523/Jneurosci.18-22-09163.1998  0.401
1998 Azpiazu I, Gautam N. G protein ysubunit interaction with muscarinic receptors Faseb Journal. 12: A1365.  0.401
1997 Giambarella U, Yamatsuji T, Okamoto T, Matsui T, Ikezu T, Murayama Y, Levine MA, Katz A, Gautam N, Nishimoto I. G protein betagamma complex-mediated apoptosis by familial Alzheimer's disease mutant of APP. The Embo Journal. 16: 4897-907. PMID 9305632 DOI: 10.1093/Emboj/16.16.4897  0.516
1997 Yan K, Gautam N. Structural determinants for interaction with three different effectors on the G protein beta subunit. The Journal of Biological Chemistry. 272: 2056-9. PMID 8999902 DOI: 10.1074/Jbc.272.4.2056  0.441
1996 Wang JL, Kalyanaraman S, Vivo MD, Gautam N. Bombesin and thrombin affect discrete pools of intracellular calcium through different G-proteins. The Biochemical Journal. 320: 87-91. PMID 8947471 DOI: 10.1042/Bj3200087  0.405
1996 Yan K, Gautam N. A domain on the G protein beta subunit interacts with both adenylyl cyclase 2 and the muscarinic atrial potassium channel. The Journal of Biological Chemistry. 271: 17597-600. PMID 8663592 DOI: 10.1074/Jbc.271.30.17597  0.476
1996 Yan K, Kalyanaraman V, Gautam N. Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families. The Journal of Biological Chemistry. 271: 7141-6. PMID 8636150 DOI: 10.1074/Jbc.271.12.7141  0.538
1996 Downes G, Kalyanaraman S, Fong H, Gautam N. Gene structure and expression of g protein subunits Faseb Journal. 10: A1099.  0.754
1995 Kisselev O, Ermolaeva M, Gautam N. Efficient interaction with a receptor requires a specific type of prenyl group on the G protein gamma subunit. The Journal of Biological Chemistry. 270: 25356-8. PMID 7592699 DOI: 10.1074/Jbc.270.43.25356  0.571
1995 Kisselev O, Pronin A, Ermolaeva M, Gautam N. Receptor-G protein coupling is established by a potential conformational switch in the beta gamma complex. Proceedings of the National Academy of Sciences of the United States of America. 92: 9102-6. PMID 7568081 DOI: 10.1073/Pnas.92.20.9102  0.567
1995 Kalyanaraman S, Kalyanaraman V, Gautam N. A brain-specific G protein gamma subunit. Biochemical and Biophysical Research Communications. 216: 126-32. PMID 7488078 DOI: 10.1006/Bbrc.1995.2600  0.492
1994 Kisselev OG, Ermolaeva MV, Gautam N. A farnesylated domain in the G protein gamma subunit is a specific determinant of receptor coupling. The Journal of Biological Chemistry. 269: 21399-402. PMID 8063769  0.467
1994 Pronin AN, Gautam N. Characterization of antibodies for various G-protein beta and gamma subunits. Methods in Enzymology. 237: 482-98. PMID 7935022 DOI: 10.1016/S0076-6879(94)37085-0  0.527
1994 Gallagher C, Gautam N. Design of oligonucleotide probes for molecular cloning of beta and gamma subunits. Methods in Enzymology. 237: 471-82. PMID 7935021 DOI: 10.1016/S0076-6879(94)37084-2  0.492
1993 Pronin AN, Gautam N. Proper processing of a G protein gamma subunit depends on complex formation with a beta subunit. Febs Letters. 328: 89-93. PMID 8344437 DOI: 10.1016/0014-5793(93)80971-V  0.532
1993 Kisselev O, Gautam N. Specific interaction with rhodopsin is dependent on the gamma subunit type in a G protein. The Journal of Biological Chemistry. 268: 24519-22. PMID 8227005  0.53
1992 Pronin AN, Gautam N. Interaction between G-protein beta and gamma subunit types is selective. Proceedings of the National Academy of Sciences of the United States of America. 89: 6220-4. PMID 1631113 DOI: 10.1073/Pnas.89.13.6220  0.538
1991 Simon MI, Strathmann MP, Gautam N. Diversity of G proteins in signal transduction. Science (New York, N.Y.). 252: 802-8. PMID 1902986 DOI: 10.1126/Science.1902986  0.721
1991 Simonds WF, Butrynski JE, Gautam N, Unson CG, Spiegel AM. G-protein beta gamma dimers. Membrane targeting requires subunit coexpression and intact gamma C-A-A-X domain. The Journal of Biological Chemistry. 266: 5363-6. PMID 1706334  0.463
1990 Gautam N, Northup J, Tamir H, Simon MI. G protein diversity is increased by associations with a variety of gamma subunits. Proceedings of the National Academy of Sciences of the United States of America. 87: 7973-7. PMID 2122451 DOI: 10.1073/Pnas.87.20.7973  0.723
1989 Gautam N, Baetscher M, Aebersold R, Simon MI. A G protein gamma subunit shares homology with ras proteins. Science (New York, N.Y.). 244: 971-4. PMID 2499046 DOI: 10.1126/Science.2499046  0.705
1988 Amatruda TT, Gautam N, Fong HK, Northup JK, Simon MI. The 35- and 36-kDa beta subunits of GTP-binding regulatory proteins are products of separate genes. The Journal of Biological Chemistry. 263: 5008-11. PMID 3128533  0.563
1983 Gautam N. Identification of two closely located larval salivary protein genes in Drosophila melanogaster Mgg Molecular & General Genetics. 189: 495-500. DOI: 10.1007/BF00325916  0.318
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