| Year |
Citation |
Score |
| 2023 |
Sharma P, Zhang X, Ly K, Zhang Y, Hu Y, Ye AY, Hu J, Kim JH, Lou M, Wang C, Celuzza Q, Kondo Y, Furukawa K, Bundle DR, Furukawa K, ... Alt FW, et al. The lipid Gb3 promotes germinal center B cell responses and anti-viral immunity. Biorxiv : the Preprint Server For Biology. PMID 37790573 DOI: 10.1101/2023.09.23.559132 |
0.707 |
|
| 2023 |
Liang Z, Zhao L, Ye AY, Lin SG, Zhang Y, Guo C, Dai HQ, Ba Z, Alt FW. Contribution of the IGCR1 regulatory element and the 3' CTCF-binding elements to regulation of V(D)J recombination. Proceedings of the National Academy of Sciences of the United States of America. 120: e2306564120. PMID 37339228 DOI: 10.1073/pnas.2306564120 |
0.735 |
|
| 2023 |
Liang Z, Zhao L, Yongxin Ye A, Lin SG, Zhang Y, Guo C, Dai HQ, Ba Z, Alt FW. Contribution of the IGCR1 regulatory element and the 3 CBEs to Regulation of V(D)J Recombination. Biorxiv : the Preprint Server For Biology. PMID 37163018 DOI: 10.1101/2023.04.21.537836 |
0.303 |
|
| 2022 |
Luo S, Jing C, Ye AY, Kratochvil S, Cottrell CA, Koo JH, Chapdelaine Williams A, Francisco LV, Batra H, Lamperti E, Kalyuzhniy O, Zhang Y, Barbieri A, Manis JP, Haynes BF, ... ... Alt FW, et al. Humanized V(D)J-rearranging and TdT-expressing mouse vaccine models with physiological HIV-1 broadly neutralizing antibody precursors. Proceedings of the National Academy of Sciences of the United States of America. 120: e2217883120. PMID 36574685 DOI: 10.1073/pnas.2217883120 |
0.723 |
|
| 2022 |
Luo S, Zhang J, Kreutzberger AJB, Eaton A, Edwards RJ, Jing C, Dai HQ, Sempowski GD, Cronin K, Parks R, Ye AY, Mansouri K, Barr M, Pishesha N, Williams AC, ... ... Alt FW, et al. An Antibody from Single Human V-rearranging Mouse Neutralizes All SARS-CoV-2 Variants Through BA.5 by Inhibiting Membrane Fusion. Science Immunology. eadd5446. PMID 35951767 DOI: 10.1126/sciimmunol.add5446 |
0.702 |
|
| 2022 |
Vincendeau E, Wei W, Zhang X, Planchais C, Yu W, Lenden-Hasse H, Cokelaer T, Pipoli da Fonseca J, Mouquet H, Adams DJ, Alt FW, Jackson SP, Balmus G, Lescale C, Deriano L. SHLD1 is dispensable for 53BP1-dependent V(D)J recombination but critical for productive class switch recombination. Nature Communications. 13: 3707. PMID 35764636 DOI: 10.1038/s41467-022-31287-3 |
0.362 |
|
| 2022 |
Zhang Y, Zhang X, Dai HQ, Hu H, Alt FW. The role of chromatin loop extrusion in antibody diversification. Nature Reviews. Immunology. PMID 35169260 DOI: 10.1038/s41577-022-00679-3 |
0.329 |
|
| 2021 |
Wang Y, Wang M, Djekidel MN, Chen H, Liu D, Alt FW, Zhang Y. eccDNAs are apoptotic products with high innate immunostimulatory activity. Nature. 599: 308-314. PMID 34671165 DOI: 10.1038/s41586-021-04009-w |
0.403 |
|
| 2021 |
Cheng YC, Snavely A, Barrett LB, Zhang X, Herman C, Frost DJ, Riva P, Tochitsky I, Kawaguchi R, Singh B, Ivanis J, Huebner EA, Arvanites A, Oza V, Davidow L, ... ... Alt FW, et al. Topoisomerase I inhibition and peripheral nerve injury induce DNA breaks and ATF3-associated axon regeneration in sensory neurons. Cell Reports. 36: 109666. PMID 34496254 DOI: 10.1016/j.celrep.2021.109666 |
0.778 |
|
| 2021 |
Liang Z, Kumar V, Le Bouteiller M, Zurita J, Kenrick J, Lin SG, Lou J, Hu J, Ye AY, Boboila C, Alt FW, Frock RL. Ku70 suppresses alternative end joining in G1-arrested progenitor B cells. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34006647 DOI: 10.1073/pnas.2103630118 |
0.823 |
|
| 2021 |
Dai HQ, Hu H, Lou J, Ye AY, Ba Z, Zhang X, Zhang Y, Zhao L, Yoon HS, Chapdelaine-Williams AM, Kyritsis N, Chen H, Johnson K, Lin S, Conte A, ... ... Alt FW, et al. Loop extrusion mediates physiological Igh locus contraction for RAG scanning. Nature. PMID 33442057 DOI: 10.1038/s41586-020-03121-7 |
0.764 |
|
| 2020 |
Dai HQ, Liang Z, Chang AN, Chapdelaine-Williams AM, Alvarado B, Pollen AA, Alt FW, Schwer B. Direct analysis of brain phenotypes via neural blastocyst complementation. Nature Protocols. PMID 32778838 DOI: 10.1038/S41596-020-0364-Y |
0.791 |
|
| 2020 |
Ba Z, Lou J, Ye AY, Dai HQ, Dring EW, Lin SG, Jain S, Kyritsis N, Kieffer-Kwon KR, Casellas R, Alt FW. CTCF orchestrates long-range cohesin-driven V(D)J recombinational scanning. Nature. PMID 32717742 DOI: 10.1038/S41586-020-2578-0 |
0.753 |
|
| 2020 |
Chen H, Zhang Y, Ye AY, Du Z, Xu M, Lee CS, Hwang JK, Kyritsis N, Ba Z, Neuberg D, Littman DR, Alt FW. BCR selection and affinity maturation in Peyer's patch germinal centres. Nature. PMID 32499646 DOI: 10.1038/S41586-020-2262-4 |
0.78 |
|
| 2020 |
Tena A, Zhang Y, Kyritsis N, Devorak A, Zurita J, Wei PC, Alt FW. Induction of recurrent break cluster genes in neural progenitor cells differentiated from embryonic stem cells in culture. Proceedings of the National Academy of Sciences of the United States of America. PMID 32332169 DOI: 10.1073/Pnas.1922299117 |
0.403 |
|
| 2020 |
Tian M, McGovern K, Cheng HL, Waddicor P, Rieble L, Dao M, Chen Y, Kimble MT, Cantor E, Manfredonia N, Judson R, Chapdelaine-Williams A, Cain DW, Haynes BF, Alt FW. Conditional antibody expression to avoid central B cell deletion in humanized HIV-1 vaccine mouse models. Proceedings of the National Academy of Sciences of the United States of America. PMID 32209668 DOI: 10.1073/Pnas.1921996117 |
0.381 |
|
| 2020 |
Bradley T, Kuraoka M, Yeh CH, Tian M, Chen H, Cain DW, Chen X, Cheng C, Ellebedy AH, Parks R, Barr M, Sutherland LL, Scearce RM, Bowman CM, Bouton-Verville H, ... ... Alt FW, et al. Immune checkpoint modulation enhances HIV-1 antibody induction. Nature Communications. 11: 948. PMID 32075963 DOI: 10.1038/S41467-020-14670-W |
0.404 |
|
| 2020 |
Wang M, Wei PC, Lim CK, Gallina IS, Marshall S, Marchetto MC, Alt FW, Gage FH. Increased Neural Progenitor Proliferation in a hiPSC Model of Autism Induces Replication Stress-Associated Genome Instability. Cell Stem Cell. PMID 32004479 DOI: 10.1016/J.Stem.2019.12.013 |
0.389 |
|
| 2019 |
Saunders KO, Wiehe K, Tian M, Acharya P, Bradley T, Alam SM, Go EP, Scearce R, Sutherland L, Henderson R, Hsu AL, Borgnia MJ, Chen H, Lu X, Wu NR, ... ... Alt FW, et al. Targeted selection of HIV-specific antibody mutations by engineering B cell maturation. Science (New York, N.Y.). 366. PMID 31806786 DOI: 10.1126/Science.Aay7199 |
0.302 |
|
| 2019 |
Zhang X, Zhang Y, Ba Z, Kyritsis N, Casellas R, Alt FW. Fundamental roles of chromatin loop extrusion in antibody class switching. Nature. PMID 31666703 DOI: 10.1038/S41586-019-1723-0 |
0.424 |
|
| 2019 |
Zhang Y, Zhang X, Ba Z, Liang Z, Dring EW, Hu H, Lou J, Kyritsis N, Zurita J, Shamim MS, Presser Aiden A, Lieberman Aiden E, Alt FW. The fundamental role of chromatin loop extrusion in physiological V(D)J recombination. Nature. PMID 31511698 DOI: 10.1038/S41586-019-1547-Y |
0.378 |
|
| 2019 |
Lee C, Hu J, Alt FW. Abstract B171: Elucidating the mechanism of RAG tracking and its impacts on V(D)J recombination Cancer Immunology Research. 7. DOI: 10.1158/2326-6074.Cricimteatiaacr18-B171 |
0.43 |
|
| 2019 |
Ba Z, Jain S, Hu J, Alt F. Abstract B099: Elucidating the mechanisms that underpin RAG chromatin scanning in V(D)J recombination at antigen receptor gene loci Cancer Immunology Research. 7. DOI: 10.1158/2326-6074.Cricimteatiaacr18-B099 |
0.455 |
|
| 2019 |
Ratnaparkhe M, Wong JK, Wei P, Hlevnjak M, Kolb T, Simovic M, Haag D, Paul Y, Devens F, Northcott P, Jones DT, Kool M, Jauch A, Pastorczak A, Mlynarski W, ... ... Alt FW, et al. Abstract 3496: Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-3496 |
0.343 |
|
| 2019 |
Frock RL, Kumar V, Liang Z, Zurita J, Du Z, Lin SG, Boboila C, Alt FW. Abstract 1745: Ku70 suppresses alternative end-joining in G1-arrested progenitor B cells Cancer Research. 79: 1745-1745. DOI: 10.1158/1538-7445.Am2019-1745 |
0.776 |
|
| 2018 |
Ratnaparkhe M, Wong JKL, Wei PC, Hlevnjak M, Kolb T, Simovic M, Haag D, Paul Y, Devens F, Northcott P, Jones DTW, Kool M, Jauch A, Pastorczak A, Mlynarski W, ... ... Alt FW, et al. Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors. Nature Communications. 9: 4760. PMID 30420702 DOI: 10.1038/S41467-018-06925-4 |
0.386 |
|
| 2018 |
Chang AN, Liang Z, Dai HQ, Chapdelaine-Williams AM, Andrews N, Bronson RT, Schwer B, Alt FW. Neural blastocyst complementation enables mouse forebrain organogenesis. Nature. PMID 30305734 DOI: 10.1038/S41586-018-0586-0 |
0.81 |
|
| 2018 |
Lin SG, Ba Z, Alt FW, Zhang Y. RAG Chromatin Scanning During V(D)J Recombination and Chromatin Loop Extrusion are Related Processes. Advances in Immunology. 139: 93-135. PMID 30249335 DOI: 10.1016/Bs.Ai.2018.07.001 |
0.448 |
|
| 2018 |
Layer JV, Cleary JP, Brown AJ, Stevenson KE, Morrow SN, Van Scoyk A, Blasco RB, Karaca E, Meng FL, Frock RL, Tivey T, Kim S, Fuchs H, Chiarle R, Alt FW, et al. Parp3 promotes long-range end joining in murine cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 30213852 DOI: 10.1073/Pnas.1801591115 |
0.79 |
|
| 2018 |
Alt FW, Schwer B. DNA double-strand breaks as drivers of neural genomic change, function, and disease. Dna Repair. PMID 30195640 DOI: 10.1016/J.Dnarep.2018.08.019 |
0.611 |
|
| 2018 |
Duan H, Chen X, Boyington JC, Cheng C, Zhang Y, Jafari AJ, Stephens T, Tsybovsky Y, Kalyuzhniy O, Zhao P, Menis S, Nason MC, Normandin E, Mukhamedova M, DeKosky BJ, ... ... Alt FW, et al. Glycan Masking Focuses Immune Responses to the HIV-1 CD4-Binding Site and Enhances Elicitation of VRC01-Class Precursor Antibodies. Immunity. PMID 30076101 DOI: 10.1016/J.Immuni.2018.07.005 |
0.307 |
|
| 2018 |
Crowe JL, Shao Z, Wang XS, Wei PC, Jiang W, Lee BJ, Estes VM, Alt FW, Zha S. Kinase-dependent structural role of DNA-PKcs during immunoglobulin class switch recombination. Proceedings of the National Academy of Sciences of the United States of America. PMID 30072430 DOI: 10.1073/Pnas.1808490115 |
0.707 |
|
| 2018 |
Ru H, Mi W, Zhang P, Alt FW, Schatz DG, Liao M, Wu H. DNA melting initiates the RAG catalytic pathway. Nature Structural & Molecular Biology. PMID 30061602 DOI: 10.1038/s41594-018-0098-5 |
0.611 |
|
| 2018 |
Jain S, Ba Z, Zhang Y, Dai HQ, Alt FW. CTCF-Binding Elements Mediate Accessibility of RAG Substrates During Chromatin Scanning. Cell. PMID 29804837 DOI: 10.1016/J.Cell.2018.04.035 |
0.392 |
|
| 2018 |
Wei PC, Lee CS, Du Z, Schwer B, Zhang Y, Kao J, Zurita J, Alt FW. Three classes of recurrent DNA break clusters in brain progenitors identified by 3D proximity-based break joining assay. Proceedings of the National Academy of Sciences of the United States of America. PMID 29432181 DOI: 10.1073/Pnas.1719907115 |
0.665 |
|
| 2018 |
Panchakshari RA, Zhang X, Kumar V, Du Z, Wei PC, Kao J, Dong J, Alt FW. DNA double-strand break response factors influence end-joining features of IgH class switch and general translocation junctions. Proceedings of the National Academy of Sciences of the United States of America. PMID 29311308 DOI: 10.1073/Pnas.1719988115 |
0.459 |
|
| 2018 |
Ratnaparkhe M, Wong J, Wei P, Hlevnjak M, Northcott P, Jones DT, Kool M, Jauch A, Pastorczak A, Korshunov A, Kumar R, Downing SM, Pfister SM, Zapatka M, McKinnon PJ, ... Alt FW, et al. Abstract 1352: Inactivation of factors of DNA double-strand break repair by homologous recombination or non-homologous end-joining leads to frequent catastrophic genomic events in murine and human tumors Cancer Research. 78: 1352-1352. DOI: 10.1158/1538-7445.Am2018-1352 |
0.416 |
|
| 2018 |
Schwer B, Chang AN, Liang Z, Dai H, Chapdelaine-Williams AM, Alt FW. CRISPR/Cas9-mediated genome editing in mouse embryonic stem cells and direct analysis of brain phenotypes via neural blastocyst complementation Protocol Exchange. DOI: 10.1038/Protex.2018.107 |
0.593 |
|
| 2017 |
Paulsen BS, Mandal PK, Frock RL, Boyraz B, Yadav R, Upadhyayula S, Gutierrez-Martinez P, Ebina W, Fasth A, Kirchhausen T, Talkowski ME, Agarwal S, Alt FW, Rossi DJ. Ectopic expression of RAD52 and dn53BP1 improves homology-directed repair during CRISPR-Cas9 genome editing. Nature Biomedical Engineering. 1: 878-888. PMID 31015609 DOI: 10.1038/S41551-017-0145-2 |
0.771 |
|
| 2017 |
Willis NA, Frock RL, Menghi F, Duffey EE, Panday A, Camacho V, Hasty EP, Liu ET, Alt FW, Scully R. Mechanism of tandem duplication formation in BRCA1-mutant cells. Nature. PMID 29168504 DOI: 10.1038/Nature24477 |
0.757 |
|
| 2017 |
Nguyen HV, Dong J, Panchakshari RA, Kumar V, Alt FW, Bories JC. Histone methyltransferase MMSET promotes AID-mediated DNA breaks at the donor switch region during class switch recombination. Proceedings of the National Academy of Sciences of the United States of America. PMID 29158395 DOI: 10.1073/Pnas.1701366114 |
0.469 |
|
| 2017 |
Xing M, Bjørås M, Daniel JA, Alt FW, Oksenych V. Synthetic lethality between murine DNA repair factors XLF and DNA-PKcs is rescued by inactivation of Ku70. Dna Repair. 57: 133-138. PMID 28759779 DOI: 10.1016/J.Dnarep.2017.07.008 |
0.413 |
|
| 2017 |
Qiao Q, Wang L, Meng FL, Hwang JK, Alt FW, Wu H. AID Recognizes Structured DNA for Class Switch Recombination. Molecular Cell. PMID 28757211 DOI: 10.1016/J.Molcel.2017.06.034 |
0.322 |
|
| 2017 |
Hwang JK, Wang C, Du Z, Meyers RM, Kepler TB, Neuberg D, Kwong PD, Mascola JR, Joyce MG, Bonsignori M, Haynes BF, Yeap LS, Alt FW. Sequence intrinsic somatic mutation mechanisms contribute to affinity maturation of VRC01-class HIV-1 broadly neutralizing antibodies. Proceedings of the National Academy of Sciences of the United States of America. PMID 28747530 DOI: 10.1073/Pnas.1709203114 |
0.408 |
|
| 2017 |
Compagno M, Wang Q, Pighi C, Cheong TC, Meng FL, Poggio T, Yeap LS, Karaca E, Blasco RB, Langellotto F, Ambrogio C, Voena C, Wiestner A, Kasar SN, Brown JR, ... ... Alt FW, et al. Phosphatidylinositol 3-kinase δ blockade increases genomic instability in B cells. Nature. PMID 28199309 DOI: 10.1038/Nature21406 |
0.435 |
|
| 2017 |
Verkoczy L, Alt FW, Tian M. Human Ig knockin mice to study the development and regulation of HIV-1 broadly neutralizing antibodies. Immunological Reviews. 275: 89-107. PMID 28133799 DOI: 10.1111/Imr.12505 |
0.321 |
|
| 2017 |
Vanoli F, Ito S, Frock RL, Alt FW, Moynahan ME, Jasin M. Abstract B37: PARP inhibitor olaparib induces genomic instability in normal mammalian cells Molecular Cancer Research. 15. DOI: 10.1158/1557-3125.Dnarepair16-B37 |
0.76 |
|
| 2016 |
Chen L, Zhao L, Alt FW, Krangel MS. An Ectopic CTCF Binding Element Inhibits Tcrd Rearrangement by Limiting Contact between Vδ and Dδ Gene Segments. Journal of Immunology (Baltimore, Md. : 1950). PMID 27613698 DOI: 10.4049/Jimmunol.1601124 |
0.381 |
|
| 2016 |
Tian M, Cheng C, Chen X, Duan H, Cheng HL, Dao M, Sheng Z, Kimble M, Wang L, Lin S, Schmidt SD, Du Z, Joyce MG, Chen Y, DeKosky BJ, ... ... Alt FW, et al. Induction of HIV Neutralizing Antibody Lineages in Mice with Diverse Precursor Repertoires. Cell. 166: 1471-1484.e18. PMID 27610571 DOI: 10.1016/J.Cell.2016.07.029 |
0.316 |
|
| 2016 |
Kumar V, Alt FW, Frock RL. PAXX and XLF DNA repair factors are functionally redundant in joining DNA breaks in a G1-arrested progenitor B-cell line. Proceedings of the National Academy of Sciences of the United States of America. PMID 27601633 DOI: 10.1073/pnas.1611882113 |
0.77 |
|
| 2016 |
Zhao L, Frock RL, Du Z, Hu J, Chen L, Krangel MS, Alt FW. Orientation-specific RAG activity in chromosomal loop domains contributes to Tcrd V(D)J recombination during T cell development. The Journal of Experimental Medicine. PMID 27526713 DOI: 10.1084/Jem.20160670 |
0.758 |
|
| 2016 |
Lin SG, Ba Z, Du Z, Zhang Y, Hu J, Alt FW. Highly sensitive and unbiased approach for elucidating antibody repertoires. Proceedings of the National Academy of Sciences of the United States of America. PMID 27354528 DOI: 10.1073/Pnas.1608649113 |
0.44 |
|
| 2016 |
Bank I, DePinho RA, Brenner MB, Cassimeris J, Alt FW, Chess L. Pillars Article: A Functional T3 Molecule Associated with a Novel Heterodimer on the Surface of Immature Human Thymocytes. Nature. 1986. 322: 179-181. Journal of Immunology (Baltimore, Md. : 1950). 196: 3514-6. PMID 27183648 |
0.369 |
|
| 2016 |
Hu J, Meyers RM, Dong J, Panchakshari RA, Alt FW, Frock RL. Detecting DNA double-stranded breaks in mammalian genomes by linear amplification-mediated high-throughput genome-wide translocation sequencing. Nature Protocols. 11: 853-71. PMID 27031497 DOI: 10.1038/Nprot.2016.043 |
0.739 |
|
| 2016 |
Schwer B, Wei PC, Chang AN, Kao J, Du Z, Meyers RM, Alt FW. Transcription-associated processes cause DNA double-strand breaks and translocations in neural stem/progenitor cells. Proceedings of the National Academy of Sciences of the United States of America. 113: 2258-63. PMID 26873106 DOI: 10.1073/Pnas.1525564113 |
0.836 |
|
| 2016 |
Wei PC, Chang AN, Kao J, Du Z, Meyers RM, Alt FW, Schwer B. Long Neural Genes Harbor Recurrent DNA Break Clusters in Neural Stem/Progenitor Cells. Cell. 164: 644-55. PMID 26871630 DOI: 10.1016/J.Cell.2015.12.039 |
0.816 |
|
| 2016 |
Garot A, Marquet M, Saintamand A, Bender S, Le Noir S, Rouaud P, Carrion C, Oruc Z, Bébin AG, Moreau J, Lebrigand K, Denizot Y, Alt FW, Cogné M, Pinaud E. Sequential activation and distinct functions for distal and proximal modules within the IgH 3' regulatory region. Proceedings of the National Academy of Sciences of the United States of America. PMID 26831080 DOI: 10.1073/Pnas.1514090113 |
0.455 |
|
| 2016 |
Hu J, Zhang Y, Zhao L, Frock R, Du Z, Meyers RM, Meng F, Schatz DG, Alt FW. Abstract A180: Topologically associated domains genome-wide restrict the off-target activity of recombination activating gene 1/2 endonuclease Cancer Immunology Research. 4. DOI: 10.1158/2326-6074.Cricimteatiaacr15-A180 |
0.823 |
|
| 2016 |
Hu J, Lin SG, Ba Z, Du Z, Zhang Y, Alt FW. Abstract B087: Revealing antibody repertoires and RAG tracking by linear amplification mediated-high-throughput genome-wide translocation sequencing Cancer Immunology Research. 4. DOI: 10.1158/2326-6066.Imm2016-B087 |
0.41 |
|
| 2016 |
Ba Z, Hu J, Du Z, Lin SG, Wesemann DR, Alt FW. Abstract A033: Mechanisms that mediate intralocus and interlocus regulation of V(D)J recombination at immunoglobulin light chain loci Cancer Immunology Research. 4. DOI: 10.1158/2326-6066.Imm2016-A033 |
0.506 |
|
| 2016 |
Mandal PK, Paulsen BS, Frock R, Gutierrez-Martinez P, Ebina W, Agarwal S, Alt F, Rossi DJ. 568. Transient Manipulation of DNA Damage Repair Pathway Choice Improves Homology-Directed Repair During CRISPR/Cas9-Mediated Genome Editing Molecular Therapy. 24: S227. DOI: 10.1016/S1525-0016(16)33376-7 |
0.759 |
|
| 2015 |
Hu J, Zhang Y, Zhao L, Frock RL, Du Z, Meyers RM, Meng FL, Schatz DG, Alt FW. Chromosomal Loop Domains Direct the Recombination of Antigen Receptor Genes. Cell. 163: 947-59. PMID 26593423 DOI: 10.1016/J.Cell.2015.10.016 |
0.799 |
|
| 2015 |
Yeap LS, Hwang JK, Du Z, Meyers RM, Meng FL, Jakubauskaitė A, Liu M, Mani V, Neuberg D, Kepler TB, Wang JH, Alt FW. Sequence-Intrinsic Mechanisms that Target AID Mutational Outcomes on Antibody Genes. Cell. PMID 26582132 DOI: 10.1016/J.Cell.2015.10.042 |
0.414 |
|
| 2015 |
Dong J, Panchakshari RA, Zhang T, Zhang Y, Hu J, Volpi SA, Meyers RM, Ho YJ, Du Z, Robbiani DF, Meng F, Gostissa M, Nussenzweig MC, Manis JP, Alt FW. Orientation-specific joining of AID-initiated DNA breaks promotes antibody class switching. Nature. 525: 134-9. PMID 26308889 DOI: 10.1038/Nature14970 |
0.476 |
|
| 2015 |
Hwang JK, Alt FW, Yeap LS. Related Mechanisms of Antibody Somatic Hypermutation and Class Switch Recombination. Microbiology Spectrum. 3. PMID 26104555 DOI: 10.1128/Microbiolspec.Mdna3-0037-2014 |
0.446 |
|
| 2015 |
Ba Z, Meng FL, Gostissa M, Huang PY, Ke Q, Wang Z, Dao MN, Fujiwara Y, Rajewsky K, Zhang B, Alt FW. A Rapid Embryonic Stem Cell-Based Mouse Model for B-cell Lymphomas Driven by Epstein-Barr Virus Protein LMP1. Cancer Immunology Research. 3: 641-9. PMID 25934172 DOI: 10.1158/2326-6066.Cir-15-0058 |
0.444 |
|
| 2015 |
Zhang B, Calado DP, Wang Z, Fröhler S, Köchert K, Qian Y, Koralov SB, Schmidt-Supprian M, Sasaki Y, Unitt C, Rodig S, Chen W, Dalla-Favera R, Alt FW, Pasqualucci L, et al. An oncogenic role for alternative NF-κB signaling in DLBCL revealed upon deregulated BCL6 expression. Cell Reports. 11: 715-26. PMID 25921526 DOI: 10.1016/J.Celrep.2015.03.059 |
0.31 |
|
| 2015 |
Jiang W, Lee BJ, Li C, Dubois RL, Gostissa M, Alt FW, Zha S. Aberrant TCRδ rearrangement underlies the T-cell lymphocytopenia and t(12;14) translocation associated with ATM deficiency. Blood. 125: 2665-8. PMID 25721125 DOI: 10.1182/Blood-2015-01-622621 |
0.658 |
|
| 2015 |
Lin SG, Guo C, Su A, Zhang Y, Alt FW. CTCF-binding elements 1 and 2 in the Igh intergenic control region cooperatively regulate V(D)J recombination. Proceedings of the National Academy of Sciences of the United States of America. 112: 1815-20. PMID 25624508 DOI: 10.1073/Pnas.1424936112 |
0.395 |
|
| 2015 |
Frock RL, Hu J, Meyers RM, Ho YJ, Kii E, Alt FW. Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases. Nature Biotechnology. 33: 179-86. PMID 25503383 DOI: 10.1038/Nbt.3101 |
0.733 |
|
| 2015 |
Compagno M, Qi W, Pighi C, Meng F, Cheong T, Poggio T, Langellotto F, Voena C, Gostissa M, Alt F, Chiarle R. PI3Kdelta Inhibitors Increase Genomic Instability By Upregulating Aid Expression Blood. 126: 164-164. DOI: 10.1182/Blood.V126.23.164.164 |
0.452 |
|
| 2014 |
Meng FL, Du Z, Federation A, Hu J, Wang Q, Kieffer-Kwon KR, Meyers RM, Amor C, Wasserman CR, Neuberg D, Casellas R, Nussenzweig MC, Bradner JE, Liu XS, Alt FW. Convergent transcription at intragenic super-enhancers targets AID-initiated genomic instability. Cell. 159: 1538-48. PMID 25483776 DOI: 10.1016/J.Cell.2014.11.014 |
0.436 |
|
| 2014 |
Hu J, Tepsuporn S, Meyers RM, Gostissa M, Alt FW. Developmental propagation of V(D)J recombination-associated DNA breaks and translocations in mature B cells via dicentric chromosomes. Proceedings of the National Academy of Sciences of the United States of America. 111: 10269-74. PMID 24982162 DOI: 10.1073/Pnas.1410112111 |
0.845 |
|
| 2014 |
Tepsuporn S, Hu J, Gostissa M, Alt FW. Mechanisms that can promote peripheral B-cell lymphoma in ATM-deficient mice. Cancer Immunology Research. 2: 857-66. PMID 24913718 DOI: 10.1158/2326-6066.Cir-14-0090 |
0.839 |
|
| 2014 |
Kumar V, Alt FW, Oksenych V. Reprint of "Functional overlaps between XLF and the ATM-dependent DNA double strand break response". Dna Repair. 17: 52-63. PMID 24767946 DOI: 10.1016/J.Dnarep.2014.04.004 |
0.469 |
|
| 2014 |
Macdonald LE, Karow M, Stevens S, Auerbach W, Poueymirou WT, Yasenchak J, Frendewey D, Valenzuela DM, Giallourakis CC, Alt FW, Yancopoulos GD, Murphy AJ. Precise and in situ genetic humanization of 6 Mb of mouse immunoglobulin genes. Proceedings of the National Academy of Sciences of the United States of America. 111: 5147-52. PMID 24706858 DOI: 10.1073/Pnas.1323896111 |
0.502 |
|
| 2014 |
Kumar V, Alt FW, Oksenych V. Functional overlaps between XLF and the ATM-dependent DNA double strand break response. Dna Repair. 16: 11-22. PMID 24674624 DOI: 10.1016/J.Dnarep.2014.01.010 |
0.469 |
|
| 2014 |
Gostissa M, Schwer B, Chang A, Dong J, Meyers RM, Marecki GT, Choi VW, Chiarle R, Zarrin AA, Alt FW. IgH class switching exploits a general property of two DNA breaks to be joined in cis over long chromosomal distances. Proceedings of the National Academy of Sciences of the United States of America. 111: 2644-9. PMID 24550291 DOI: 10.1073/Pnas.1324176111 |
0.835 |
|
| 2014 |
Lee YN, Frugoni F, Dobbs K, Walter JE, Giliani S, Gennery AR, Al-Herz W, Haddad E, LeDeist F, Bleesing JH, Henderson LA, Pai SY, Nelson RP, El-Ghoneimy DH, El-Feky RA, ... ... Alt FW, et al. A systematic analysis of recombination activity and genotype-phenotype correlation in human recombination-activating gene 1 deficiency. The Journal of Allergy and Clinical Immunology. 133: 1099-108. PMID 24290284 DOI: 10.1016/J.Jaci.2013.10.007 |
0.425 |
|
| 2013 |
Shin J, He M, Liu Y, Paredes S, Villanova L, Brown K, Qiu X, Nabavi N, Mohrin M, Wojnoonski K, Li P, Cheng HL, Murphy AJ, Valenzuela DM, Luo H, ... ... Alt FW, et al. SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease. Cell Reports. 5: 654-65. PMID 24210820 DOI: 10.1016/J.Celrep.2013.10.007 |
0.446 |
|
| 2013 |
Dougan SK, Ashour J, Karssemeijer RA, Popp MW, Avalos AM, Barisa M, Altenburg AF, Ingram JR, Cragnolini JJ, Guo C, Alt FW, Jaenisch R, Ploegh HL. Antigen-specific B-cell receptor sensitizes B cells to infection by influenza virus. Nature. 503: 406-9. PMID 24141948 DOI: 10.1038/Nature12637 |
0.344 |
|
| 2013 |
Medvedovic J, Ebert A, Tagoh H, Tamir IM, Schwickert TA, Novatchkova M, Sun Q, Huis In 't Veld PJ, Guo C, Yoon HS, Denizot Y, Holwerda SJ, de Laat W, Cogné M, Shi Y, ... Alt FW, et al. Flexible long-range loops in the VH gene region of the Igh locus facilitate the generation of a diverse antibody repertoire. Immunity. 39: 229-44. PMID 23973221 DOI: 10.1016/J.Immuni.2013.08.011 |
0.359 |
|
| 2013 |
Wesemann DR, Portuguese AJ, Meyers RM, Gallagher MP, Cluff-Jones K, Magee JM, Panchakshari RA, Rodig SJ, Kepler TB, Alt FW. Microbial colonization influences early B-lineage development in the gut lamina propria. Nature. 501: 112-5. PMID 23965619 DOI: 10.1038/Nature12496 |
0.447 |
|
| 2013 |
Callen E, Di Virgilio M, Kruhlak MJ, Nieto-Soler M, Wong N, Chen HT, Faryabi RB, Polato F, Santos M, Starnes LM, Wesemann DR, Lee JE, Tubbs A, Sleckman BP, Daniel JA, ... ... Alt FW, et al. 53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions. Cell. 153: 1266-80. PMID 23727112 DOI: 10.1016/J.Cell.2013.05.023 |
0.414 |
|
| 2013 |
Shi W, Bain AL, Schwer B, Al-Ejeh F, Smith C, Wong L, Chai H, Miranda MS, Ho U, Kawaguchi M, Miura Y, Finnie JW, Wall M, Heierhorst J, Wicking C, ... ... Alt FW, et al. Essential developmental, genomic stability, and tumour suppressor functions of the mouse orthologue of hSSB1/NABP2. Plos Genetics. 9: e1003298. PMID 23408915 DOI: 10.1371/Journal.Pgen.1003298 |
0.68 |
|
| 2013 |
Selimyan R, Gerstein RM, Ivanova I, Precht P, Subrahmanyam R, Perlot T, Alt FW, Sen R. Localized DNA demethylation at recombination intermediates during immunoglobulin heavy chain gene assembly. Plos Biology. 11: e1001475. PMID 23382652 DOI: 10.1371/Journal.Pbio.1001475 |
0.432 |
|
| 2013 |
Gostissa M, Bianco JM, Malkin DJ, Kutok JL, Rodig SJ, Morse HC, Bassing CH, Alt FW. Conditional inactivation of p53 in mature B cells promotes generation of nongerminal center-derived B-cell lymphomas. Proceedings of the National Academy of Sciences of the United States of America. 110: 2934-9. PMID 23382223 DOI: 10.1073/Pnas.1222570110 |
0.425 |
|
| 2013 |
Alt FW, Zhang Y, Meng FL, Guo C, Schwer B. Mechanisms of programmed DNA lesions and genomic instability in the immune system. Cell. 152: 417-29. PMID 23374339 DOI: 10.1016/J.Cell.2013.01.007 |
0.636 |
|
| 2013 |
Rass E, Chandramouly G, Zha S, Alt FW, Xie A. Ataxia telangiectasia mutated (ATM) is dispensable for endonuclease I-SceI-induced homologous recombination in mouse embryonic stem cells. The Journal of Biological Chemistry. 288: 7086-95. PMID 23355489 DOI: 10.1074/Jbc.M112.445825 |
0.689 |
|
| 2013 |
Oksenych V, Kumar V, Liu X, Guo C, Schwer B, Zha S, Alt FW. Functional redundancy between the XLF and DNA-PKcs DNA repair factors in V(D)J recombination and nonhomologous DNA end joining. Proceedings of the National Academy of Sciences of the United States of America. 110: 2234-9. PMID 23345432 DOI: 10.1073/Pnas.1222573110 |
0.789 |
|
| 2013 |
Boboila C, Yan C, Wesemann DR, Jankovic M, Wang JH, Manis J, Nussenzweig A, Nussenzweig M, Alt FW. Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4 Journal of Experimental Medicine. 210: 641. DOI: 10.1084/jem.200924492103c |
0.737 |
|
| 2013 |
Shin J, He M, Liu Y, Paredes S, Villanova L, Brown K, Qiu X, Nabavi N, Mohrin M, Wojnoonski K, Li P, Cheng HL, Murphy A, Valenzuela D, Luo H, ... ... Alt F, et al. Correction to SIRT7 Represses Myc Activity to Suppress ER Stress and Prevent Fatty Liver Disease. [Cell Reports 5, 7, (2013)] 654-665 Cell Reports. 5: 1479. DOI: 10.1016/J.Celrep.2013.11.036 |
0.377 |
|
| 2012 |
Subrahmanyam R, Du H, Ivanova I, Chakraborty T, Ji Y, Zhang Y, Alt FW, Schatz DG, Sen R. Localized epigenetic changes induced by DH recombination restricts recombinase to DJH junctions. Nature Immunology. 13: 1205-12. PMID 23104096 DOI: 10.1038/Ni.2447 |
0.55 |
|
| 2012 |
Boboila C, Alt FW, Schwer B. Classical and alternative end-joining pathways for repair of lymphocyte-specific and general DNA double-strand breaks. Advances in Immunology. 116: 1-49. PMID 23063072 DOI: 10.1016/B978-0-12-394300-2.00001-6 |
0.834 |
|
| 2012 |
Wesemann DR, Portuguese AJ, Magee JM, Gallagher MP, Zhou X, Panchakshari RA, Alt FW. Reprogramming IgH isotype-switched B cells to functional-grade induced pluripotent stem cells. Proceedings of the National Academy of Sciences of the United States of America. 109: 13745-50. PMID 22869756 DOI: 10.1073/Pnas.1210286109 |
0.445 |
|
| 2012 |
Westerberg LS, Dahlberg C, Baptista M, Moran CJ, Detre C, Keszei M, Eston MA, Alt FW, Terhorst C, Notarangelo LD, Snapper SB. Wiskott-Aldrich syndrome protein (WASP) and N-WASP are critical for peripheral B-cell development and function. Blood. 119: 3966-74. PMID 22411869 DOI: 10.1182/Blood-2010-09-308197 |
0.431 |
|
| 2012 |
Zhang Y, McCord RP, Ho YJ, Lajoie BR, Hildebrand DG, Simon AC, Becker MS, Alt FW, Dekker J. Spatial organization of the mouse genome and its role in recurrent chromosomal translocations. Cell. 148: 908-21. PMID 22341456 DOI: 10.1016/J.Cell.2012.02.002 |
0.349 |
|
| 2012 |
Boboila C, Oksenych V, Gostissa M, Wang JH, Zha S, Zhang Y, Chai H, Lee CS, Jankovic M, Saez LM, Nussenzweig MC, McKinnon PJ, Alt FW, Schwer B. Robust chromosomal DNA repair via alternative end-joining in the absence of X-ray repair cross-complementing protein 1 (XRCC1). Proceedings of the National Academy of Sciences of the United States of America. 109: 2473-8. PMID 22308491 DOI: 10.1073/Pnas.1121470109 |
0.842 |
|
| 2012 |
Oksenych V, Alt FW, Kumar V, Schwer B, Wesemann DR, Hansen E, Patel H, Su A, Guo C. Functional redundancy between repair factor XLF and damage response mediator 53BP1 in V(D)J recombination and DNA repair. Proceedings of the National Academy of Sciences of the United States of America. 109: 2455-60. PMID 22308489 DOI: 10.1073/Pnas.1121458109 |
0.682 |
|
| 2012 |
Yancopoulos GD, Alt FW. Developmentally controlled and tissue-specific expression of unrearranged VH gene segments. Cell. 1985. 40: 271-281. Journal of Immunology (Baltimore, Md. : 1950). 188: 10-20. PMID 22187482 |
0.441 |
|
| 2011 |
Wesemann DR, Magee JM, Boboila C, Calado DP, Gallagher MP, Portuguese AJ, Manis JP, Zhou X, Recher M, Rajewsky K, Notarangelo LD, Alt FW. Immature B cells preferentially switch to IgE with increased direct Sμ to Sε recombination. The Journal of Experimental Medicine. 208: 2733-46. PMID 22143888 DOI: 10.1084/Jem.20111155 |
0.746 |
|
| 2011 |
Chiarle R, Zhang Y, Frock RL, Lewis SM, Molinie B, Ho YJ, Myers DR, Choi VW, Compagno M, Malkin DJ, Neuberg D, Monti S, Giallourakis CC, Gostissa M, Alt FW. Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells. Cell. 147: 107-19. PMID 21962511 DOI: 10.1016/J.Cell.2011.07.049 |
0.763 |
|
| 2011 |
Guo C, Yoon HS, Franklin A, Jain S, Ebert A, Cheng HL, Hansen E, Despo O, Bossen C, Vettermann C, Bates JG, Richards N, Myers D, Patel H, Gallagher M, ... ... Alt FW, et al. CTCF-binding elements mediate control of V(D)J recombination. Nature. 477: 424-30. PMID 21909113 DOI: 10.1038/Nature10495 |
0.354 |
|
| 2011 |
Gutierrez A, Kentsis A, Sanda T, Holmfeldt L, Chen SC, Zhang J, Protopopov A, Chin L, Dahlberg SE, Neuberg DS, Silverman LB, Winter SS, Hunger SP, Sallan SE, Zha S, ... Alt FW, et al. The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia. Blood. 118: 4169-73. PMID 21878675 DOI: 10.1182/Blood-2010-11-318873 |
0.658 |
|
| 2011 |
Hirschey MD, Shimazu T, Jing E, Grueter CA, Collins AM, Aouizerat B, StanÄáková A, Goetzman E, Lam MM, Schwer B, Stevens RD, Muehlbauer MJ, Kakar S, Bass NM, Kuusisto J, ... ... Alt FW, et al. SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. Molecular Cell. 44: 177-90. PMID 21856199 DOI: 10.1016/J.Molcel.2011.07.019 |
0.662 |
|
| 2011 |
Rucci F, Poliani PL, Caraffi S, Paganini T, Fontana E, Giliani S, Alt FW, Notarangelo LD. Abnormalities of thymic stroma may contribute to immune dysregulation in murine models of leaky severe combined immunodeficiency. Frontiers in Immunology. 2. PMID 21822418 DOI: 10.3389/Fimmu.2011.00015 |
0.378 |
|
| 2011 |
Jeevan-Raj BP, Robert I, Heyer V, Page A, Wang JH, Cammas F, Alt FW, Losson R, Reina-San-Martin B. Epigenetic tethering of AID to the donor switch region during immunoglobulin class switch recombination. The Journal of Experimental Medicine. 208: 1649-60. PMID 21746811 DOI: 10.1084/Jem.20110118 |
0.349 |
|
| 2011 |
Ise W, Kohyama M, Schraml BU, Zhang T, Schwer B, Basu U, Alt FW, Tang J, Oltz EM, Murphy TL, Murphy KM. The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells. Nature Immunology. 12: 536-43. PMID 21572431 DOI: 10.1038/Ni.2037 |
0.722 |
|
| 2011 |
Guo C, Alt FW, Giallourakis C. PAIRing for distal Igh locus V(D)J recombination. Immunity. 34: 139-41. PMID 21349424 DOI: 10.1016/J.Immuni.2011.02.010 |
0.344 |
|
| 2011 |
Green MR, Monti S, Dalla-Favera R, Pasqualucci L, Walsh NC, Schmidt-Supprian M, Kutok JL, Rodig SJ, Neuberg DS, Rajewsky K, Golub TR, Alt FW, Shipp MA, Manis JP. Signatures of murine B-cell development implicate Yy1 as a regulator of the germinal center-specific program. Proceedings of the National Academy of Sciences of the United States of America. 108: 2873-8. PMID 21282644 DOI: 10.1073/Pnas.1019537108 |
0.425 |
|
| 2011 |
Basu U, Meng FL, Keim C, Grinstein V, Pefanis E, Eccleston J, Zhang T, Myers D, Wasserman CR, Wesemann DR, Januszyk K, Gregory RI, Deng H, Lima CD, Alt FW. The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates. Cell. 144: 353-63. PMID 21255825 DOI: 10.1016/J.Cell.2011.01.001 |
0.794 |
|
| 2011 |
Zha S, Jiang W, Fujiwara Y, Patel H, Goff PH, Brush JW, Dubois RL, Alt FW. Ataxia telangiectasia-mutated protein and DNA-dependent protein kinase have complementary V(D)J recombination functions. Proceedings of the National Academy of Sciences of the United States of America. 108: 2028-33. PMID 21245310 DOI: 10.1073/Pnas.1019293108 |
0.717 |
|
| 2011 |
Eccleston J, Yan C, Yuan K, Alt FW, Selsing E. Mismatch repair proteins MSH2, MLH1, and EXO1 are important for class-switch recombination events occurring in B cells that lack nonhomologous end joining. Journal of Immunology (Baltimore, Md. : 1950). 186: 2336-43. PMID 21242524 DOI: 10.4049/Jimmunol.1003104 |
0.489 |
|
| 2011 |
Gostissa M, Alt FW, Chiarle R. Mechanisms that promote and suppress chromosomal translocations in lymphocytes. Annual Review of Immunology. 29: 319-50. PMID 21219174 DOI: 10.1146/Annurev-Immunol-031210-101329 |
0.41 |
|
| 2011 |
Zha S, Guo C, Boboila C, Oksenych V, Cheng HL, Zhang Y, Wesemann DR, Yuen G, Patel H, Goff PH, Dubois RL, Alt FW. ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks. Nature. 469: 250-4. PMID 21160472 DOI: 10.1038/Nature09604 |
0.833 |
|
| 2011 |
Wesemann D, Boboila C, Gallagher M, Alt F. Early B Lineage Cells Display Class Switch Preference To Ige Journal of Allergy and Clinical Immunology. 127: AB92-AB92. DOI: 10.1016/J.Jaci.2010.12.370 |
0.749 |
|
| 2010 |
Giallourakis CC, Franklin A, Guo C, Cheng HL, Yoon HS, Gallagher M, Perlot T, Andzelm M, Murphy AJ, Macdonald LE, Yancopoulos GD, Alt FW. Elements between the IgH variable (V) and diversity (D) clusters influence antisense transcription and lineage-specific V(D)J recombination. Proceedings of the National Academy of Sciences of the United States of America. 107: 22207-12. PMID 21123744 DOI: 10.1073/Pnas.1015954107 |
0.547 |
|
| 2010 |
Shimazu T, Hirschey MD, Hua L, Dittenhafer-Reed KE, Schwer B, Lombard DB, Li Y, Bunkenborg J, Alt FW, Denu JM, Jacobson MP, Verdin E. SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production. Cell Metabolism. 12: 654-61. PMID 21109197 DOI: 10.1016/J.Cmet.2010.11.003 |
0.669 |
|
| 2010 |
Schwer B, Schumacher B, Lombard DB, Xiao C, Kurtev MV, Gao J, Schneider JI, Chai H, Bronson RT, Tsai LH, Deng CX, Alt FW. Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity. Proceedings of the National Academy of Sciences of the United States of America. 107: 21790-4. PMID 21098266 DOI: 10.1073/Pnas.1016306107 |
0.609 |
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| 2010 |
Perlot T, Pawlitzky I, Manis JP, Zarrin AA, Brodeur PH, Alt FW. Analysis of mice lacking DNaseI hypersensitive sites at the 5' end of the IgH locus. Plos One. 5: e13992. PMID 21085586 DOI: 10.1371/Journal.Pone.0013992 |
0.406 |
|
| 2010 |
Zhang Y, Gostissa M, Hildebrand DG, Becker MS, Boboila C, Chiarle R, Lewis S, Alt FW. The role of mechanistic factors in promoting chromosomal translocations found in lymphoid and other cancers. Advances in Immunology. 106: 93-133. PMID 20728025 DOI: 10.1016/S0065-2776(10)06004-9 |
0.759 |
|
| 2010 |
Zha S, Bassing CH, Sanda T, Brush JW, Patel H, Goff PH, Murphy MM, Tepsuporn S, Gatti RA, Look AT, Alt FW. ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplification. The Journal of Experimental Medicine. 207: 1369-80. PMID 20566716 DOI: 10.1084/Jem.20100285 |
0.826 |
|
| 2010 |
Walter JE, Rucci F, Patrizi L, Recher M, Regenass S, Paganini T, Keszei M, Pessach I, Lang PA, Poliani PL, Giliani S, Al-Herz W, Cowan MJ, Puck JM, Bleesing J, ... ... Alt FW, et al. Expansion of immunoglobulin-secreting cells and defects in B cell tolerance in Rag-dependent immunodeficiency. The Journal of Experimental Medicine. 207: 1541-54. PMID 20547827 DOI: 10.1084/Jem.20091927 |
0.426 |
|
| 2010 |
Westerberg LS, Meelu P, Baptista M, Eston MA, Adamovich DA, Cotta-de-Almeida V, Seed B, Rosen MK, Vandenberghe P, Thrasher AJ, Klein C, Alt FW, Snapper SB. Activating WASP mutations associated with X-linked neutropenia result in enhanced actin polymerization, altered cytoskeletal responses, and genomic instability in lymphocytes. The Journal of Experimental Medicine. 207: 1145-52. PMID 20513746 DOI: 10.1084/Jem.20091245 |
0.4 |
|
| 2010 |
De Ravin SS, Cowen EW, Zarember KA, Whiting-Theobald NL, Kuhns DB, Sandler NG, Douek DC, Pittaluga S, Poliani PL, Lee YN, Notarangelo LD, Wang L, Alt FW, Kang EM, Milner JD, et al. Hypomorphic Rag mutations can cause destructive midline granulomatous disease. Blood. 116: 1263-71. PMID 20489056 DOI: 10.1182/Blood-2010-02-267583 |
0.361 |
|
| 2010 |
Hirschey MD, Shimazu T, Goetzman E, Jing E, Schwer B, Lombard DB, Grueter CA, Harris C, Biddinger S, Ilkayeva OR, Stevens RD, Li Y, Saha AK, Ruderman NB, Bain JR, ... ... Alt FW, et al. SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature. 464: 121-5. PMID 20203611 DOI: 10.1038/Nature08778 |
0.652 |
|
| 2010 |
Boboila C, Yan C, Wesemann DR, Jankovic M, Wang JH, Manis J, Nussenzweig A, Nussenzweig M, Alt FW. Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4. The Journal of Experimental Medicine. 207: 417-27. PMID 20142431 DOI: 10.1084/Jem.20092449 |
0.797 |
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| 2010 |
Boboila C, Jankovic M, Yan CT, Wang JH, Wesemann DR, Zhang T, Fazeli A, Feldman L, Nussenzweig A, Nussenzweig M, Alt FW. Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70. Proceedings of the National Academy of Sciences of the United States of America. 107: 3034-9. PMID 20133803 DOI: 10.1073/Pnas.0915067107 |
0.782 |
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| 2010 |
Zhang T, Franklin A, Boboila C, McQuay A, Gallagher MP, Manis JP, Khamlichi AA, Alt FW. Downstream class switching leads to IgE antibody production by B lymphocytes lacking IgM switch regions. Proceedings of the National Academy of Sciences of the United States of America. 107: 3040-5. PMID 20133637 DOI: 10.1073/Pnas.0915072107 |
0.758 |
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| 2010 |
Rucci F, Notarangelo LD, Fazeli A, Patrizi L, Hickernell T, Paganini T, Coakley KM, Detre C, Keszei M, Walter JE, Feldman L, Cheng HL, Poliani PL, Wang JH, Balter BB, ... ... Alt FW, et al. Homozygous DNA ligase IV R278H mutation in mice leads to leaky SCID and represents a model for human LIG4 syndrome. Proceedings of the National Academy of Sciences of the United States of America. 107: 3024-9. PMID 20133615 DOI: 10.1073/Pnas.0914865107 |
0.679 |
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| 2010 |
Sommer CA, Sommer AG, Longmire TA, Christodoulou C, Thomas DD, Gostissa M, Alt FW, Murphy GJ, Kotton DN, Mostoslavsky G. Excision of reprogramming transgenes improves the differentiation potential of iPS cells generated with a single excisable vector. Stem Cells (Dayton, Ohio). 28: 64-74. PMID 19904830 DOI: 10.1002/Stem.255 |
0.358 |
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| 2010 |
Gutierrez A, Kentsis A, Sanda T, Etchin J, Protopopov A, Zhang J, Chin L, Silverman LB, Winter S, Hunger S, Sallan SE, Zha S, Alt F, Look AT. The BCL11B Tumor Suppressor Is Mutated In Human T-Cell Acute Lymphoblastic Leukemia Blood. 116: 4177-4177. DOI: 10.1182/Blood.V116.21.4177.4177 |
0.672 |
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| 2010 |
Walter J, Rucci F, Detre C, Patrizi L, Recher M, Keszei M, Pessach I, Lang P, Regenass S, Sekiguchi J, Alt F, Notarangelo L. Defects of B Cell Tolerance and Expansion of Immunoglobulin Secreting Cells in Rag-dependent Immunodeficiency Clinical Immunology. 135: S17-S18. DOI: 10.1016/J.Clim.2010.03.057 |
0.387 |
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| 2009 |
Gostissa M, Yan CT, Bianco JM, Cogné M, Pinaud E, Alt FW. Long-range oncogenic activation of Igh-c-myc translocations by the Igh 3' regulatory region. Nature. 462: 803-7. PMID 20010689 DOI: 10.1038/Nature08633 |
0.466 |
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| 2009 |
Lee YN, Alt FW, Reyes J, Gleason M, Zarrin AA, Jung D. Differential utilization of T cell receptor TCR alpha/TCR delta locus variable region gene segments is mediated by accessibility. Proceedings of the National Academy of Sciences of the United States of America. 106: 17487-92. PMID 19805067 DOI: 10.1073/Pnas.0909723106 |
0.585 |
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| 2009 |
Zha S, Boboila C, Alt FW. Mre11: roles in DNA repair beyond homologous recombination. Nature Structural & Molecular Biology. 16: 798-800. PMID 19654615 DOI: 10.1038/Nsmb0809-798 |
0.807 |
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| 2009 |
Schwer B, Eckersdorff M, Li Y, Silva JC, Fermin D, Kurtev MV, Giallourakis C, Comb MJ, Alt FW, Lombard DB. Calorie restriction alters mitochondrial protein acetylation. Aging Cell. 8: 604-6. PMID 19594485 DOI: 10.1111/J.1474-9726.2009.00503.X |
0.544 |
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| 2009 |
Wang JH, Gostissa M, Yan CT, Goff P, Hickernell T, Hansen E, Difilippantonio S, Wesemann DR, Zarrin AA, Rajewsky K, Nussenzweig A, Alt FW. Mechanisms promoting translocations in editing and switching peripheral B cells. Nature. 460: 231-6. PMID 19587764 DOI: 10.1038/Nature08159 |
0.501 |
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| 2009 |
Callén E, Jankovic M, Wong N, Zha S, Chen HT, Difilippantonio S, Di Virgilio M, Heidkamp G, Alt FW, Nussenzweig A, Nussenzweig M. Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes. Molecular Cell. 34: 285-97. PMID 19450527 DOI: 10.1016/J.Molcel.2009.04.025 |
0.699 |
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| 2009 |
Basu U, Franklin A, Schwer B, Cheng HL, Chaudhuri J, Alt FW. Regulation of activation-induced cytidine deaminase DNA deamination activity in B-cells by Ser38 phosphorylation. Biochemical Society Transactions. 37: 561-8. PMID 19442251 DOI: 10.1042/Bst0370561 |
0.824 |
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| 2009 |
Chakraborty T, Perlot T, Subrahmanyam R, Jani A, Goff PH, Zhang Y, Ivanova I, Alt FW, Sen R. A 220-nucleotide deletion of the intronic enhancer reveals an epigenetic hierarchy in immunoglobulin heavy chain locus activation. The Journal of Experimental Medicine. 206: 1019-27. PMID 19414554 DOI: 10.1084/Jem.20081621 |
0.346 |
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| 2009 |
Carpenter AC, Yang-Iott KS, Chao LH, Nuskey B, Whitlow S, Alt FW, Bassing CH. Assembled DJ beta complexes influence TCR beta chain selection and peripheral V beta repertoire. Journal of Immunology (Baltimore, Md. : 1950). 182: 5586-95. PMID 19380806 DOI: 10.4049/Jimmunol.0803270 |
0.357 |
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| 2009 |
Schenten D, Kracker S, Esposito G, Franco S, Klein U, Murphy M, Alt FW, Rajewsky K. Pol zeta ablation in B cells impairs the germinal center reaction, class switch recombination, DNA break repair, and genome stability. The Journal of Experimental Medicine. 206: 477-90. PMID 19204108 DOI: 10.1084/Jem.20080669 |
0.487 |
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| 2009 |
Cheng HL, Vuong BQ, Basu U, Franklin A, Schwer B, Astarita J, Phan RT, Datta A, Manis J, Alt FW, Chaudhuri J. Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in mice. Proceedings of the National Academy of Sciences of the United States of America. 106: 2717-22. PMID 19196992 DOI: 10.1073/Pnas.0812304106 |
0.808 |
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| 2009 |
Gostissa M, Ranganath S, Bianco JM, Alt FW. Chromosomal location targets different MYC family gene members for oncogenic translocations. Proceedings of the National Academy of Sciences of the United States of America. 106: 2265-70. PMID 19174520 DOI: 10.1073/Pnas.0812763106 |
0.427 |
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| 2009 |
Giblin W, Chatterji M, Westfield G, Masud T, Theisen B, Cheng HL, DeVido J, Alt FW, Ferguson DO, Schatz DG, Sekiguchi J. Leaky severe combined immunodeficiency and aberrant DNA rearrangements due to a hypomorphic RAG1 mutation. Blood. 113: 2965-75. PMID 19126872 DOI: 10.1182/Blood-2008-07-165167 |
0.667 |
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| 2009 |
Basu U, Franklin A, Alt FW. Post-translational regulation of activation-induced cytidine deaminase. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 364: 667-73. PMID 19010772 DOI: 10.1098/Rstb.2008.0194 |
0.622 |
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| 2009 |
Walter J, Rucci F, Patrizi L, Andersson E, Keszei M, Yan C, Gavanescu I, Poliani P, Sekiguchi J, Alt F, Notarangelo L. F.121. B Cell-mediated Autoimmunity in Hypomorphic rag1 and lig4 Mouse Mutants as Models for Human Leaky SCID Clinical Immunology. 131: S126. DOI: 10.1016/J.Clim.2009.03.373 |
0.344 |
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| 2008 |
Perlot T, Alt FW. Cis-regulatory elements and epigenetic changes control genomic rearrangements of the IgH locus. Advances in Immunology. 99: 1-32. PMID 19117530 DOI: 10.1016/S0065-2776(08)00601-9 |
0.377 |
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| 2008 |
Wang JH, Alt FW, Gostissa M, Datta A, Murphy M, Alimzhanov MB, Coakley KM, Rajewsky K, Manis JP, Yan CT. Oncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switching. The Journal of Experimental Medicine. 205: 3079-90. PMID 19064702 DOI: 10.1084/Jem.20082271 |
0.494 |
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| 2008 |
Oberdoerffer P, Michan S, McVay M, Mostoslavsky R, Vann J, Park SK, Hartlerode A, Stegmuller J, Hafner A, Loerch P, Wright SM, Mills KD, Bonni A, Yankner BA, Scully R, ... ... Alt FW, et al. SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell. 135: 907-18. PMID 19041753 DOI: 10.1016/J.Cell.2008.10.025 |
0.396 |
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| 2008 |
Basu U, Wang Y, Alt FW. Evolution of phosphorylation-dependent regulation of activation-induced cytidine deaminase. Molecular Cell. 32: 285-91. PMID 18951095 DOI: 10.1016/J.Molcel.2008.08.019 |
0.598 |
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| 2008 |
Bassing CH, Whitlow S, Mostoslavsky R, Mostoslovasky R, Yang-Iott K, Ranganath S, Alt FW. Vbeta cluster sequences reduce the frequency of primary Vbeta2 and Vbeta14 rearrangements. European Journal of Immunology. 38: 2564-72. PMID 18792409 DOI: 10.1002/Eji.200838347 |
0.328 |
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| 2008 |
Li G, Alt FW, Cheng HL, Brush JW, Goff PH, Murphy MM, Franco S, Zhang Y, Zha S. Lymphocyte-specific compensation for XLF/cernunnos end-joining functions in V(D)J recombination. Molecular Cell. 31: 631-40. PMID 18775323 DOI: 10.1016/J.Molcel.2008.07.017 |
0.71 |
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| 2008 |
Takizawa M, Tolarová H, Li Z, Dubois W, Lim S, Callen E, Franco S, Mosaico M, Feigenbaum L, Alt FW, Nussenzweig A, Potter M, Casellas R. AID expression levels determine the extent of cMyc oncogenic translocations and the incidence of B cell tumor development. The Journal of Experimental Medicine. 205: 1949-57. PMID 18678733 DOI: 10.1084/Jem.20081007 |
0.473 |
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| 2008 |
Zha S, Sekiguchi J, Brush JW, Bassing CH, Alt FW. Complementary functions of ATM and H2AX in development and suppression of genomic instability. Proceedings of the National Academy of Sciences of the United States of America. 105: 9302-6. PMID 18599436 DOI: 10.1073/Pnas.0803520105 |
0.684 |
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| 2008 |
Walkley CR, Qudsi R, Sankaran VG, Perry JA, Gostissa M, Roth SI, Rodda SJ, Snay E, Dunning P, Fahey FH, Alt FW, McMahon AP, Orkin SH. Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease. Genes & Development. 22: 1662-76. PMID 18559481 DOI: 10.1101/Gad.1656808 |
0.306 |
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| 2008 |
Zarrin AA, Goff PH, Senger K, Alt FW. Sgamma3 switch sequences function in place of endogenous Sgamma1 to mediate antibody class switching. The Journal of Experimental Medicine. 205: 1567-72. PMID 18541713 DOI: 10.1084/Jem.20080451 |
0.403 |
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| 2008 |
Franco S, Murphy MM, Li G, Borjeson T, Boboila C, Alt FW. DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombination. The Journal of Experimental Medicine. 205: 557-64. PMID 18316419 DOI: 10.1084/Jem.20080044 |
0.798 |
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| 2008 |
Lee IH, Cao L, Mostoslavsky R, Lombard DB, Liu J, Bruns NE, Tsokos M, Alt FW, Finkel T. A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy. Proceedings of the National Academy of Sciences of the United States of America. 105: 3374-9. PMID 18296641 DOI: 10.1073/Pnas.0712145105 |
0.344 |
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| 2008 |
Perlot T, Li G, Alt FW. Antisense transcripts from immunoglobulin heavy-chain locus V(D)J and switch regions. Proceedings of the National Academy of Sciences of the United States of America. 105: 3843-8. PMID 18292225 DOI: 10.1073/Pnas.0712291105 |
0.391 |
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| 2008 |
Ranganath S, Carpenter AC, Gleason M, Shaw AC, Bassing CH, Alt FW. Productive coupling of accessible Vbeta14 segments and DJbeta complexes determines the frequency of Vbeta14 rearrangement. Journal of Immunology (Baltimore, Md. : 1950). 180: 2339-46. PMID 18250443 DOI: 10.4049/Jimmunol.180.4.2339 |
0.422 |
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| 2008 |
Lombard DB, Schwer B, Alt FW, Mostoslavsky R. SIRT6 in DNA repair, metabolism and ageing. Journal of Internal Medicine. 263: 128-41. PMID 18226091 DOI: 10.1111/J.1365-2796.2007.01902.X |
0.608 |
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| 2008 |
Zhang Y, Kwon S, Yamaguchi T, Cubizolles F, Rousseaux S, Kneissel M, Cao C, Li N, Cheng HL, Chua K, Lombard D, Mizeracki A, Matthias G, Alt FW, Khochbin S, et al. Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally. Molecular and Cellular Biology. 28: 1688-701. PMID 18180281 DOI: 10.1128/Mcb.01154-06 |
0.311 |
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| 2008 |
Jabara HH, Chaudhuri J, Dutt S, Dedeoglu F, Weng Y, Murphy MM, Franco S, Alt FW, Manis J, Geha RS. B-cell receptor cross-linking delays activation-induced cytidine deaminase induction and inhibits class-switch recombination to IgE. The Journal of Allergy and Clinical Immunology. 121: 191-196.e2. PMID 17900678 DOI: 10.1016/j.jaci.2007.08.008 |
0.648 |
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| 2008 |
Bassing CH, Ranganath S, Murphy M, Savic V, Gleason M, Alt FW. Aberrant V(D)J recombination is not required for rapid development of H2ax/p53-deficient thymic lymphomas with clonal translocations. Blood. 111: 2163-9. PMID 17855626 DOI: 10.1182/Blood-2007-08-104760 |
0.412 |
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| 2008 |
Takeyama K, Monti S, Manis JP, Dal Cin P, Getz G, Beroukhim R, Dutt S, Aster JC, Alt FW, Golub TR, Shipp MA. Integrative analysis reveals 53BP1 copy loss and decreased expression in a subset of human diffuse large B-cell lymphomas. Oncogene. 27: 318-22. PMID 17637749 DOI: 10.1038/Sj.Onc.1210650 |
0.395 |
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| 2007 |
Xie A, Hartlerode A, Stucki M, Odate S, Puget N, Kwok A, Nagaraju G, Yan C, Alt FW, Chen J, Jackson SP, Scully R. Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair. Molecular Cell. 28: 1045-57. PMID 18158901 DOI: 10.1016/J.Molcel.2007.12.005 |
0.334 |
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| 2007 |
Wuerffel R, Wang L, Grigera F, Manis J, Selsing E, Perlot T, Alt FW, Cogne M, Pinaud E, Kenter AL. S-S synapsis during class switch recombination is promoted by distantly located transcriptional elements and activation-induced deaminase. Immunity. 27: 711-22. PMID 17980632 DOI: 10.1016/J.Immuni.2007.09.007 |
0.373 |
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| 2007 |
Alt FW. From gene amplification to V(D)J recombination and back: a personal account of my early years in B cell biology. European Journal of Immunology. 37: S138-47. PMID 17972338 DOI: 10.1002/Eji.200737848 |
0.401 |
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| 2007 |
Lombard DB, Alt FW, Cheng HL, Bunkenborg J, Streeper RS, Mostoslavsky R, Kim J, Yancopoulos G, Valenzuela D, Murphy A, Yang Y, Chen Y, Hirschey MD, Bronson RT, Haigis M, et al. Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Molecular and Cellular Biology. 27: 8807-14. PMID 17923681 DOI: 10.1128/Mcb.01636-07 |
0.714 |
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| 2007 |
Cotta-de-Almeida V, Westerberg L, Maillard MH, Onaldi D, Wachtel H, Meelu P, Chung UI, Xavier R, Alt FW, Snapper SB. Wiskott Aldrich syndrome protein (WASP) and N-WASP are critical for T cell development. Proceedings of the National Academy of Sciences of the United States of America. 104: 15424-9. PMID 17878299 DOI: 10.1073/Pnas.0706881104 |
0.337 |
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| 2007 |
Yan CT, Boboila C, Souza EK, Franco S, Hickernell TR, Murphy M, Gumaste S, Geyer M, Zarrin AA, Manis JP, Rajewsky K, Alt FW. IgH class switching and translocations use a robust non-classical end-joining pathway. Nature. 449: 478-82. PMID 17713479 DOI: 10.1038/Nature06020 |
0.8 |
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| 2007 |
Chaudhuri J, Basu U, Zarrin A, Yan C, Franco S, Perlot T, Vuong B, Wang J, Phan RT, Datta A, Manis J, Alt FW. Evolution of the immunoglobulin heavy chain class switch recombination mechanism. Advances in Immunology. 94: 157-214. PMID 17560275 DOI: 10.1016/S0065-2776(06)94006-1 |
0.769 |
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| 2007 |
Fraenkel S, Mostoslavsky R, Novobrantseva TI, Pelanda R, Chaudhuri J, Esposito G, Jung S, Alt FW, Rajewsky K, Cedar H, Bergman Y. Allelic 'choice' governs somatic hypermutation in vivo at the immunoglobulin kappa-chain locus. Nature Immunology. 8: 715-22. PMID 17546032 DOI: 10.1038/Ni1476 |
0.782 |
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| 2007 |
Zha S, Alt FW, Cheng HL, Brush JW, Li G. Defective DNA repair and increased genomic instability in Cernunnos-XLF-deficient murine ES cells. Proceedings of the National Academy of Sciences of the United States of America. 104: 4518-23. PMID 17360556 DOI: 10.1073/Pnas.0611734104 |
0.735 |
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| 2007 |
Wu C, Ranganath S, Gleason M, Woodman BB, Borjeson TM, Alt FW, Bassing CH. Restriction of endogenous T cell antigen receptor beta rearrangements to Vbeta14 through selective recombination signal sequence modifications. Proceedings of the National Academy of Sciences of the United States of America. 104: 4002-7. PMID 17360467 DOI: 10.1073/Pnas.0700081104 |
0.388 |
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| 2007 |
Basu U, Chaudhuri J, Phan RT, Datta A, Alt FW. Regulation of activation induced deaminase via phosphorylation. Advances in Experimental Medicine and Biology. 596: 129-37. PMID 17338181 DOI: 10.1007/0-387-46530-8_11 |
0.772 |
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| 2007 |
Zarrin AA, Del Vecchio C, Tseng E, Gleason M, Zarin P, Tian M, Alt FW. Antibody class switching mediated by yeast endonuclease-generated DNA breaks. Science (New York, N.Y.). 315: 377-81. PMID 17170253 DOI: 10.1126/Science.1136386 |
0.449 |
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| 2006 |
Mostoslavsky G, Fabian AJ, Rooney S, Alt FW, Mulligan RC. Complete correction of murine Artemis immunodeficiency by lentiviral vector-mediated gene transfer. Proceedings of the National Academy of Sciences of the United States of America. 103: 16406-11. PMID 17062750 DOI: 10.1073/Pnas.0608130103 |
0.812 |
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| 2006 |
Haigis MC, Mostoslavsky R, Haigis KM, Fahie K, Christodoulou DC, Murphy AJ, Valenzuela DM, Yancopoulos GD, Karow M, Blander G, Wolberger C, Prolla TA, Weindruch R, Alt FW, Guarente L. SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell. 126: 941-54. PMID 16959573 DOI: 10.1016/J.Cell.2006.06.057 |
0.481 |
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| 2006 |
Franco S, Alt FW, Manis JP. Pathways that suppress programmed DNA breaks from progressing to chromosomal breaks and translocations. Dna Repair. 5: 1030-41. PMID 16934538 DOI: 10.1016/J.Dnarep.2006.05.024 |
0.451 |
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| 2006 |
Shen RR, Ferguson DO, Renard M, Hoyer KK, Kim U, Hao X, Alt FW, Roeder RG, Morse HC, Teitell MA. Dysregulated TCL1 requires the germinal center and genome instability for mature B-cell transformation. Blood. 108: 1991-8. PMID 16728701 DOI: 10.1182/Blood-2006-02-001354 |
0.431 |
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| 2006 |
Yan CT, Kaushal D, Murphy M, Zhang Y, Datta A, Chen C, Monroe B, Mostoslavsky G, Coakley K, Gao Y, Mills KD, Fazeli AP, Tepsuporn S, Hall G, Mulligan R, ... ... Alt FW, et al. XRCC4 suppresses medulloblastomas with recurrent translocations in p53-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. 103: 7378-83. PMID 16670198 DOI: 10.1073/Pnas.0601938103 |
0.81 |
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| 2006 |
Puebla-Osorio N, Lacey DB, Alt FW, Zhu C. Early embryonic lethality due to targeted inactivation of DNA ligase III. Molecular and Cellular Biology. 26: 3935-41. PMID 16648486 DOI: 10.1128/Mcb.26.10.3935-3941.2006 |
0.418 |
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| 2006 |
Vaquero A, Scher MB, Lee DH, Sutton A, Cheng HL, Alt FW, Serrano L, Sternglanz R, Reinberg D. SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis. Genes & Development. 20: 1256-61. PMID 16648462 DOI: 10.1101/Gad.1412706 |
0.307 |
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| 2006 |
Jung D, Giallourakis C, Mostoslavsky R, Alt FW. Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus. Annual Review of Immunology. 24: 541-70. PMID 16551259 DOI: 10.1146/Annurev.Immunol.23.021704.115830 |
0.599 |
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| 2006 |
Morales JC, Franco S, Murphy MM, Bassing CH, Mills KD, Adams MM, Walsh NC, Manis JP, Rassidakis GZ, Alt FW, Carpenter PB. 53BP1 and p53 synergize to suppress genomic instability and lymphomagenesis. Proceedings of the National Academy of Sciences of the United States of America. 103: 3310-5. PMID 16492765 DOI: 10.1073/Pnas.0511259103 |
0.406 |
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| 2006 |
Longerich S, Basu U, Alt F, Storb U. AID in somatic hypermutation and class switch recombination. Current Opinion in Immunology. 18: 164-74. PMID 16464563 DOI: 10.1016/J.Coi.2006.01.008 |
0.622 |
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| 2006 |
Mostoslavsky R, Chua KF, Lombard DB, Pang WW, Fischer MR, Gellon L, Liu P, Mostoslavsky G, Franco S, Murphy MM, Mills KD, Patel P, Hsu JT, Hong AL, Ford E, ... ... Alt FW, et al. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell. 124: 315-29. PMID 16439206 DOI: 10.1016/J.Cell.2005.11.044 |
0.656 |
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| 2006 |
Franco S, Gostissa M, Zha S, Lombard DB, Murphy MM, Zarrin AA, Yan C, Tepsuporn S, Morales JC, Adams MM, Lou Z, Bassing CH, Manis JP, Chen J, Carpenter PB, ... Alt FW, et al. H2AX prevents DNA breaks from progressing to chromosome breaks and translocations. Molecular Cell. 21: 201-14. PMID 16427010 DOI: 10.1016/J.Molcel.2006.01.005 |
0.829 |
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| 2006 |
Lou Z, Minter-Dykhouse K, Franco S, Gostissa M, Rivera MA, Celeste A, Manis JP, van Deursen J, Nussenzweig A, Paull TT, Alt FW, Chen J. MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Molecular Cell. 21: 187-200. PMID 16427009 DOI: 10.1016/J.Molcel.2005.11.025 |
0.416 |
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| 2006 |
O'Neil J, Calvo J, McKenna K, Krishnamoorthy V, Aster JC, Bassing CH, Alt FW, Kelliher M, Look AT. Activating Notch1 mutations in mouse models of T-ALL. Blood. 107: 781-5. PMID 16166587 DOI: 10.1182/Blood-2005-06-2553 |
0.33 |
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| 2006 |
Longerich S, Basu U, Alt F, Storb U. AID in somatic hypermutation and class switch recombination [Current Opinion in Immunology 2006, 18:164-174] (DOI:10.1016/j.coi.2006.01.008) Current Opinion in Immunology. 18: 769. DOI: 10.1016/J.Coi.2006.09.017 |
0.535 |
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| 2005 |
Schelonka RL, Ivanov II, Jung DH, Ippolito GC, Nitschke L, Zhuang Y, Gartland GL, Pelkonen J, Alt FW, Rajewsky K, Schroeder HW. A single DH gene segment creates its own unique CDR-H3 repertoire and is sufficient for B cell development and immune function. Journal of Immunology (Baltimore, Md. : 1950). 175: 6624-32. PMID 16272317 DOI: 10.4049/Jimmunol.175.10.6624 |
0.627 |
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| 2005 |
Basu U, Chaudhuri J, Alpert C, Dutt S, Ranganath S, Li G, Schrum JP, Manis JP, Alt FW. The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation. Nature. 438: 508-11. PMID 16251902 DOI: 10.1038/Nature04255 |
0.768 |
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| 2005 |
Perlot T, Alt FW, Bassing CH, Suh H, Pinaud E. Elucidation of IgH intronic enhancer functions via germ-line deletion. Proceedings of the National Academy of Sciences of the United States of America. 102: 14362-7. PMID 16186486 DOI: 10.1073/Pnas.0507090102 |
0.417 |
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| 2005 |
Chua KF, Mostoslavsky R, Lombard DB, Pang WW, Saito S, Franco S, Kaushal D, Cheng HL, Fischer MR, Stokes N, Murphy MM, Appella E, Alt FW. Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress. Cell Metabolism. 2: 67-76. PMID 16054100 DOI: 10.1016/J.Cmet.2005.06.007 |
0.361 |
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| 2005 |
Snapper SB, Meelu P, Nguyen D, Stockton BM, Bozza P, Alt FW, Rosen FS, von Andrian UH, Klein C. WASP deficiency leads to global defects of directed leukocyte migration in vitro and in vivo. Journal of Leukocyte Biology. 77: 993-8. PMID 15774550 DOI: 10.1189/Jlb.0804444 |
0.357 |
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| 2005 |
Lombard DB, Chua KF, Mostoslavsky R, Franco S, Gostissa M, Alt FW. DNA repair, genome stability, and aging. Cell. 120: 497-512. PMID 15734682 DOI: 10.1016/J.Cell.2005.01.028 |
0.333 |
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| 2005 |
Dudley DD, Chaudhuri J, Bassing CH, Alt FW. Mechanism and control of V(D)J recombination versus class switch recombination: similarities and differences. Advances in Immunology. 86: 43-112. PMID 15705419 DOI: 10.1016/S0065-2776(04)86002-4 |
0.832 |
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| 2005 |
Rooney S, Alt FW, Sekiguchi J, Manis JP. Artemis-independent functions of DNA-dependent protein kinase in Ig heavy chain class switch recombination and development. Proceedings of the National Academy of Sciences of the United States of America. 102: 2471-5. PMID 15699324 DOI: 10.1073/Pnas.0409857102 |
0.844 |
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| 2005 |
Zarrin AA, Tian M, Wang J, Borjeson T, Alt FW. Influence of switch region length on immunoglobulin class switch recombination. Proceedings of the National Academy of Sciences of the United States of America. 102: 2466-70. PMID 15684074 DOI: 10.1073/Pnas.0409847102 |
0.321 |
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| 2005 |
Kang J, Ferguson D, Song H, Bassing C, Eckersdorff M, Alt FW, Xu Y. Functional interaction of H2AX, NBS1, and p53 in ATM-dependent DNA damage responses and tumor suppression. Molecular and Cellular Biology. 25: 661-70. PMID 15632067 DOI: 10.1128/Mcb.25.2.661-670.2005 |
0.53 |
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| 2005 |
Chen J, Gorman JR, Stewart V, Williams B, Jacks T, Alt FW. Generation of normal lymphocyte populations by Rb-deficient embryonic stem cells. Current Biology : Cb. 3: 405-13. PMID 15335707 DOI: 10.1016/0960-9822(93)90347-Q |
0.41 |
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| 2004 |
Xie A, Puget N, Shim I, Odate S, Jarzyna I, Bassing CH, Alt FW, Scully R. Control of sister chromatid recombination by histone H2AX. Molecular Cell. 16: 1017-25. PMID 15610743 DOI: 10.1016/J.Molcel.2004.12.007 |
0.39 |
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| 2004 |
Nussenzweig MC, Alt FW. Antibody diversity: one enzyme to rule them all. Nature Medicine. 10: 1304-5. PMID 15580255 DOI: 10.1038/Nm1204-1304 |
0.412 |
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| 2004 |
Zarrin AA, Alt FW, Chaudhuri J, Stokes N, Kaushal D, Du Pasquier L, Tian M. An evolutionarily conserved target motif for immunoglobulin class-switch recombination. Nature Immunology. 5: 1275-81. PMID 15531884 DOI: 10.1038/Ni1137 |
0.658 |
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| 2004 |
Ansel KM, Greenwald RJ, Agarwal S, Bassing CH, Monticelli S, Interlandi J, Djuretic IM, Lee DU, Sharpe AH, Alt FW, Rao A. Deletion of a conserved Il4 silencer impairs T helper type 1-mediated immunity. Nature Immunology. 5: 1251-9. PMID 15516924 DOI: 10.1038/Ni1135 |
0.308 |
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| 2004 |
Mostoslavsky R, Alt FW, Rajewsky K. The lingering enigma of the allelic exclusion mechanism. Cell. 118: 539-44. PMID 15339659 DOI: 10.1016/J.Cell.2004.08.023 |
0.356 |
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| 2004 |
Talukder SR, Dudley DD, Alt FW, Takahama Y, Akamatsu Y. Increased frequency of aberrant V(D)J recombination products in core RAG-expressing mice. Nucleic Acids Research. 32: 4539-49. PMID 15328366 DOI: 10.1093/Nar/Gkh778 |
0.719 |
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| 2004 |
Bassing CH, Alt FW. The cellular response to general and programmed DNA double strand breaks. Dna Repair. 3: 781-96. PMID 15279764 DOI: 10.1016/J.Dnarep.2004.06.001 |
0.447 |
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| 2004 |
Chaudhuri J, Khuong C, Alt FW. Replication protein A interacts with AID to promote deamination of somatic hypermutation targets. Nature. 430: 992-8. PMID 15273694 DOI: 10.1038/Nature02821 |
0.704 |
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| 2004 |
Rooney S, Chaudhuri J, Alt FW. The role of the non-homologous end-joining pathway in lymphocyte development. Immunological Reviews. 200: 115-31. PMID 15242400 DOI: 10.1111/J.0105-2896.2004.00165.X |
0.827 |
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| 2004 |
Chaudhuri J, Alt FW. Class-switch recombination: interplay of transcription, DNA deamination and DNA repair. Nature Reviews. Immunology. 4: 541-52. PMID 15229473 DOI: 10.1038/Nri1395 |
0.69 |
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| 2004 |
Couëdel C, Mills KD, Barchi M, Shen L, Olshen A, Johnson RD, Nussenzweig A, Essers J, Kanaar R, Li GC, Alt FW, Jasin M. Collaboration of homologous recombination and nonhomologous end-joining factors for the survival and integrity of mice and cells. Genes & Development. 18: 1293-304. PMID 15175261 DOI: 10.1101/Gad.1209204 |
0.42 |
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| 2004 |
Mills KD, Ferguson DO, Essers J, Eckersdorff M, Kanaar R, Alt FW. Rad54 and DNA Ligase IV cooperate to maintain mammalian chromatid stability. Genes & Development. 18: 1283-92. PMID 15175260 DOI: 10.1101/Gad.1204304 |
0.422 |
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| 2004 |
Giallourakis C, Alt FW, Bassing CH. V(D)J recombinational accessibility-heading in the opposite direction? Nature Immunology. 5: 561-2. PMID 15164012 DOI: 10.1038/Ni0604-561 |
0.364 |
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| 2004 |
Mostoslavsky R, Alt FW. Receptor revision in T cells: an open question? Trends in Immunology. 25: 276-9. PMID 15145316 DOI: 10.1016/J.It.2004.04.001 |
0.369 |
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| 2004 |
Manis JP, Morales JC, Xia Z, Kutok JL, Alt FW, Carpenter PB. 53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination. Nature Immunology. 5: 481-7. PMID 15077110 DOI: 10.1038/Ni1067 |
0.491 |
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| 2004 |
Tian M, Jones DA, Smith M, Shinkura R, Alt FW. Deficiency in the nuclease activity of xeroderma pigmentosum G in mice leads to hypersensitivity to UV irradiation. Molecular and Cellular Biology. 24: 2237-42. PMID 14993263 DOI: 10.1128/Mcb.24.6.2237-2242.2004 |
0.446 |
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| 2004 |
Rooney S, Sekiguchi J, Whitlow S, Eckersdorff M, Manis JP, Lee C, Ferguson DO, Alt FW. Artemis and p53 cooperate to suppress oncogenic N-myc amplification in progenitor B cells. Proceedings of the National Academy of Sciences of the United States of America. 101: 2410-5. PMID 14983023 DOI: 10.1073/Pnas.0308757101 |
0.82 |
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| 2004 |
Dedeoglu F, Horwitz B, Chaudhuri J, Alt FW, Geha RS. Induction of activation-induced cytidine deaminase gene expression by IL-4 and CD40 ligation is dependent on STAT6 and NFkappaB. International Immunology. 16: 395-404. PMID 14978013 DOI: 10.1093/Intimm/Dxh042 |
0.651 |
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| 2004 |
Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, Tran H, Ross SE, Mostoslavsky R, Cohen HY, Hu LS, Cheng HL, Jedrychowski MP, Gygi SP, Sinclair DA, ... Alt FW, et al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science (New York, N.Y.). 303: 2011-5. PMID 14976264 DOI: 10.1126/Science.1094637 |
0.489 |
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| 2004 |
Jung D, Alt FW. Unraveling V(D)J recombination; insights into gene regulation. Cell. 116: 299-311. PMID 14744439 DOI: 10.1016/S0092-8674(04)00039-X |
0.581 |
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| 2004 |
Tian M, Shinkura R, Shinkura N, Alt FW. Growth retardation, early death, and DNA repair defects in mice deficient for the nucleotide excision repair enzyme XPF. Molecular and Cellular Biology. 24: 1200-5. PMID 14729965 DOI: 10.1128/Mcb.24.3.1200-1205.2004 |
0.423 |
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| 2004 |
Chaudhuri J, Alt FW. Erratum: Class-switch recombination: interplay of transcription, DNA deamination and DNA repair Nature Reviews Immunology. 4: 655-655. DOI: 10.1038/nri1425 |
0.635 |
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| 2003 |
Theunissen JW, Kaplan MI, Hunt PA, Williams BR, Ferguson DO, Alt FW, Petrini JH. Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice. Molecular Cell. 12: 1511-23. PMID 14690604 DOI: 10.1016/S1097-2765(03)00455-6 |
0.392 |
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| 2003 |
Pivniouk VI, Snapper SB, Kettner A, Alenius H, Laouini D, Falet H, Hartwig J, Alt FW, Geha RS. Impaired signaling via the high-affinity IgE receptor in Wiskott-Aldrich syndrome protein-deficient mast cells. International Immunology. 15: 1431-40. PMID 14645152 DOI: 10.1093/Intimm/Dxg148 |
0.352 |
|
| 2003 |
Exley MA, Bigley NJ, Cheng O, Shaulov A, Tahir SM, Carter QL, Garcia J, Wang C, Patten K, Stills HF, Alt FW, Snapper SB, Balk SP. Innate immune response to encephalomyocarditis virus infection mediated by CD1d. Immunology. 110: 519-26. PMID 14632651 DOI: 10.1111/J.1365-2567.2003.01779.X |
0.318 |
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| 2003 |
Fujikawa K, Miletic AV, Alt FW, Faccio R, Brown T, Hoog J, Fredericks J, Nishi S, Mildiner S, Moores SL, Brugge J, Rosen FS, Swat W. Vav1/2/3-null mice define an essential role for Vav family proteins in lymphocyte development and activation but a differential requirement in MAPK signaling in T and B cells. The Journal of Experimental Medicine. 198: 1595-608. PMID 14623913 DOI: 10.1084/Jem.20030874 |
0.398 |
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| 2003 |
Dudley DD, Sekiguchi J, Zhu C, Sadofsky MJ, Whitlow S, DeVido J, Monroe RJ, Bassing CH, Alt FW. Impaired V(D)J recombination and lymphocyte development in core RAG1-expressing mice. The Journal of Experimental Medicine. 198: 1439-50. PMID 14581608 DOI: 10.1084/Jem.20030627 |
0.724 |
|
| 2003 |
Cheng HL, Mostoslavsky R, Saito S, Manis JP, Gu Y, Patel P, Bronson R, Appella E, Alt FW, Chua KF. Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. 100: 10794-9. PMID 12960381 DOI: 10.1073/Pnas.1934713100 |
0.404 |
|
| 2003 |
Bassing CH, Suh H, Ferguson DO, Chua KF, Manis J, Eckersdorff M, Gleason M, Bronson R, Lee C, Alt FW. Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors. Cell. 114: 359-70. PMID 12914700 DOI: 10.1016/S0092-8674(03)00566-X |
0.446 |
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| 2003 |
Mills KD, Ferguson DO, Alt FW. The role of DNA breaks in genomic instability and tumorigenesis. Immunological Reviews. 194: 77-95. PMID 12846809 DOI: 10.1034/J.1600-065X.2003.00060.X |
0.445 |
|
| 2003 |
Manis JP, Alt FW. Novel antibody switching defects in human patients. The Journal of Clinical Investigation. 112: 19-22. PMID 12840053 DOI: 10.1172/Jci19091 |
0.324 |
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| 2003 |
Mostoslavsky R, Alt FW, Bassing CH. Chromatin dynamics and locus accessibility in the immune system. Nature Immunology. 4: 603-6. PMID 12830134 DOI: 10.1038/Ni0703-603 |
0.385 |
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| 2003 |
Enzler T, Gillessen S, Manis JP, Ferguson D, Fleming J, Alt FW, Mihm M, Dranoff G. Deficiencies of GM-CSF and interferon gamma link inflammation and cancer. The Journal of Experimental Medicine. 197: 1213-9. PMID 12732663 DOI: 10.1084/Jem.20021258 |
0.323 |
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| 2003 |
Chaudhuri J, Tian M, Khuong C, Chua K, Pinaud E, Alt FW. Transcription-targeted DNA deamination by the AID antibody diversification enzyme. Nature. 422: 726-30. PMID 12692563 DOI: 10.1038/Nature01574 |
0.692 |
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| 2003 |
Shinkura R, Tian M, Smith M, Chua K, Fujiwara Y, Alt FW. The influence of transcriptional orientation on endogenous switch region function. Nature Immunology. 4: 435-41. PMID 12679811 DOI: 10.1038/Ni918 |
0.347 |
|
| 2003 |
Rooney S, Alt FW, Lombard D, Whitlow S, Eckersdorff M, Fleming J, Fugmann S, Ferguson DO, Schatz DG, Sekiguchi J. Defective DNA repair and increased genomic instability in Artemis-deficient murine cells. The Journal of Experimental Medicine. 197: 553-65. PMID 12615897 DOI: 10.1084/Jem.20021891 |
0.831 |
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| 2003 |
Swat W, Xavier R, Mizoguchi A, Mizoguchi E, Fredericks J, Fujikawa K, Bhan AK, Alt FW. Essential role for Vav1 in activation, but not development, of gammadelta T cells. International Immunology. 15: 215-21. PMID 12578851 DOI: 10.1093/Intimm/Dxg021 |
0.34 |
|
| 2003 |
Wong KK, Maser RS, Bachoo RM, Menon J, Carrasco DR, Gu Y, Alt FW, DePinho RA. Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing. Nature. 421: 643-8. PMID 12540856 DOI: 10.1038/Nature01385 |
0.531 |
|
| 2003 |
Zinkel SS, Ong CC, Ferguson DO, Iwasaki H, Akashi K, Bronson RT, Kutok JL, Alt FW, Korsmeyer SJ. Proapoptotic BID is required for myeloid homeostasis and tumor suppression. Genes & Development. 17: 229-39. PMID 12533511 DOI: 10.1101/Gad.1045603 |
0.335 |
|
| 2003 |
Akamatsu Y, Monroe R, Dudley DD, Elkin SK, Gartner F, Talukder SR, Takahama Y, Alt FW, Bassing CH, Oettinger MA. Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice. Proceedings of the National Academy of Sciences of the United States of America. 100: 1209-14. PMID 12531919 DOI: 10.1073/Pnas.0237043100 |
0.752 |
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| 2003 |
Manis JP, Michaelson JS, Birshtein BK, Alt FW. Elucidation of a downstream boundary of the 3' IgH regulatory region. Molecular Immunology. 39: 753-60. PMID 12531286 DOI: 10.1016/S0161-5890(02)00256-0 |
0.406 |
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| 2003 |
Wu C, Bassing CH, Jung D, Woodman BB, Foy D, Alt FW. Dramatically increased rearrangement and peripheral representation of Vbeta14 driven by the 3'Dbeta1 recombination signal sequence. Immunity. 18: 75-85. PMID 12530977 DOI: 10.1016/S1074-7613(02)00515-0 |
0.566 |
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| 2003 |
Jung D, Bassing CH, Fugmann SD, Cheng HL, Schatz DG, Alt FW. Extrachromosomal recombination substrates recapitulate beyond 12/23 restricted VDJ recombination in nonlymphoid cells. Immunity. 18: 65-74. PMID 12530976 DOI: 10.1016/S1074-7613(02)00507-1 |
0.718 |
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| 2003 |
Klein C, Nguyen D, Liu CH, Mizoguchi A, Bhan AK, Miki H, Takenawa T, Rosen FS, Alt FW, Mulligan RC, Snapper SB. Gene therapy for Wiskott-Aldrich syndrome: rescue of T-cell signaling and amelioration of colitis upon transplantation of retrovirally transduced hematopoietic stem cells in mice. Blood. 101: 2159-66. PMID 12433691 DOI: 10.1182/Blood-2002-05-1423 |
0.561 |
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| 2002 |
Rooney S, Sekiguchi J, Zhu C, Cheng HL, Manis J, Whitlow S, DeVido J, Foy D, Chaudhuri J, Lombard D, Alt FW. Leaky Scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice. Molecular Cell. 10: 1379-90. PMID 12504013 DOI: 10.1016/S1097-2765(02)00755-4 |
0.825 |
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| 2002 |
Solymar DC, Agarwal S, Bassing CH, Alt FW, Rao A. A 3' enhancer in the IL-4 gene regulates cytokine production by Th2 cells and mast cells. Immunity. 17: 41-50. PMID 12150890 DOI: 10.1016/S1074-7613(02)00334-5 |
0.322 |
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| 2002 |
Dudley DD, Manis JP, Zarrin AA, Kaylor L, Tian M, Alt FW. Internal IgH class switch region deletions are position-independent and enhanced by AID expression. Proceedings of the National Academy of Sciences of the United States of America. 99: 9984-9. PMID 12114543 DOI: 10.1073/Pnas.152333499 |
0.734 |
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| 2002 |
Zhu C, Mills KD, Ferguson DO, Lee C, Manis J, Fleming J, Gao Y, Morton CC, Alt FW. Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations. Cell. 109: 811-21. PMID 12110179 DOI: 10.1016/S0092-8674(02)00770-5 |
0.436 |
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| 2002 |
Ye Q, Press B, Kissler S, Yang XF, Lu L, Bassing CH, Sleckman BP, Jansson M, Panoutsakopoulou V, Trimble LA, Alt FW, Cantor H. T cell costimulation through CD28 depends on induction of the Bcl-xgamma isoform: analysis of Bcl-xgamma-deficient mice. The Journal of Experimental Medicine. 196: 87-95. PMID 12093873 DOI: 10.1084/Jem.20012084 |
0.318 |
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| 2002 |
Bassing CH, Chua KF, Sekiguchi J, Suh H, Whitlow SR, Fleming JC, Monroe BC, Ciccone DN, Yan C, Vlasakova K, Livingston DM, Ferguson DO, Scully R, Alt FW. Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX. Proceedings of the National Academy of Sciences of the United States of America. 99: 8173-8. PMID 12034884 DOI: 10.1073/Pnas.122228699 |
0.452 |
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| 2002 |
Chua KF, Alt FW, Manis JP. The function of AID in somatic mutation and class switch recombination: upstream or downstream of DNA breaks. The Journal of Experimental Medicine. 195: F37-41. PMID 11994429 DOI: 10.1084/Jem.20020380 |
0.444 |
|
| 2002 |
Bassing CH, Swat W, Alt FW. The mechanism and regulation of chromosomal V(D)J recombination. Cell. 109: S45-55. PMID 11983152 DOI: 10.1016/S0092-8674(02)00675-X |
0.362 |
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| 2002 |
Manis JP, Dudley D, Kaylor L, Alt FW. IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells. Immunity. 16: 607-17. PMID 11970883 DOI: 10.1016/S1074-7613(02)00306-0 |
0.762 |
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| 2002 |
Inlay M, Alt FW, Baltimore D, Xu Y. Essential roles of the kappa light chain intronic enhancer and 3' enhancer in kappa rearrangement and demethylation. Nature Immunology. 3: 463-8. PMID 11967540 DOI: 10.1038/Ni790 |
0.81 |
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| 2002 |
Fujikawa K, Inoue Y, Sakai M, Koyama Y, Nishi S, Funada R, Alt FW, Swat W. Vav3 is regulated during the cell cycle and effects cell division. Proceedings of the National Academy of Sciences of the United States of America. 99: 4313-8. PMID 11917103 DOI: 10.1073/Pnas.052715699 |
0.355 |
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| 2002 |
Krawczyk C, Oliveira-dos-Santos A, Sasaki T, Griffiths E, Ohashi PS, Snapper S, Alt F, Penninger JM. Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells. Immunity. 16: 331-43. PMID 11911819 DOI: 10.1016/S1074-7613(02)00291-1 |
0.309 |
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| 2002 |
Manis JP, Tian M, Alt FW. Mechanism and control of class-switch recombination. Trends in Immunology. 23: 31-9. PMID 11801452 DOI: 10.1016/S1471-4906(01)02111-1 |
0.338 |
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| 2002 |
Malynn BA, Shaw AC, Young F, Stewart V, Alt FW. Truncated immunoglobulin Dmu causes incomplete developmental progression of RAG-deficient pro-B cells. Molecular Immunology. 38: 547-56. PMID 11750656 DOI: 10.1016/S0161-5890(01)00085-2 |
0.447 |
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| 2001 |
Sekiguchi JA, Whitlow S, Alt FW. Increased accumulation of hybrid V(D)J joins in cells expressing truncated versus full-length RAGs. Molecular Cell. 8: 1383-90. PMID 11779512 DOI: 10.1016/S1097-2765(01)00423-3 |
0.434 |
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| 2001 |
Sharpless NE, Ferguson DO, O'Hagan RC, Castrillon DH, Lee C, Farazi PA, Alson S, Fleming J, Morton CC, Frank K, Chin L, Alt FW, DePinho RA. Impaired nonhomologous end-joining provokes soft tissue sarcomas harboring chromosomal translocations, amplifications, and deletions. Molecular Cell. 8: 1187-96. PMID 11779495 DOI: 10.1016/S1097-2765(01)00425-7 |
0.575 |
|
| 2001 |
Tsitsikov EN, Laouini D, Dunn IF, Sannikova TY, Davidson L, Alt FW, Geha RS. TRAF1 is a negative regulator of TNF signaling. enhanced TNF signaling in TRAF1-deficient mice. Immunity. 15: 647-57. PMID 11672546 DOI: 10.1016/S1074-7613(01)00207-2 |
0.352 |
|
| 2001 |
Ferguson DO, Alt FW. DNA double strand break repair and chromosomal translocation: lessons from animal models. Oncogene. 20: 5572-9. PMID 11607810 DOI: 10.1038/Sj.Onc.1204767 |
0.402 |
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| 2001 |
Snapper SB, Takeshima F, Antón I, Liu CH, Thomas SM, Nguyen D, Dudley D, Fraser H, Purich D, Lopez-Ilasaca M, Klein C, Davidson L, Bronson R, Mulligan RC, Southwick F, ... ... Alt FW, et al. N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility. Nature Cell Biology. 3: 897-904. PMID 11584271 DOI: 10.1038/Ncb1001-897 |
0.723 |
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| 2001 |
Reimold AM, Iwakoshi NN, Manis J, Vallabhajosyula P, Szomolanyi-Tsuda E, Gravallese EM, Friend D, Grusby MJ, Alt F, Glimcher LH. Plasma cell differentiation requires the transcription factor XBP-1. Nature. 412: 300-7. PMID 11460154 DOI: 10.1038/35085509 |
0.373 |
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| 2001 |
Sekiguchi J, Ferguson DO, Chen HT, Yang EM, Earle J, Frank K, Whitlow S, Gu Y, Xu Y, Nussenzweig A, Alt FW. Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development. Proceedings of the National Academy of Sciences of the United States of America. 98: 3243-8. PMID 11248063 DOI: 10.1073/Pnas.051632098 |
0.555 |
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| 2001 |
de Alboran IM, O'Hagan RC, Gärtner F, Malynn B, Davidson L, Rickert R, Rajewsky K, DePinho RA, Alt FW. Analysis of C-MYC function in normal cells via conditional gene-targeted mutation. Immunity. 14: 45-55. PMID 11163229 DOI: 10.1016/S1074-7613(01)00088-7 |
0.562 |
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| 2000 |
Ferguson DO, Sekiguchi JM, Frank KM, Gao Y, Sharpless NE, Gu Y, Manis J, DePinho RA, Alt FW. The interplay between nonhomologous end-joining and cell cycle checkpoint factors in development, genomic stability, and tumorigenesis. Cold Spring Harbor Symposia On Quantitative Biology. 65: 395-403. PMID 12760055 DOI: 10.1101/Sqb.2000.65.395 |
0.498 |
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| 2000 |
Gärtner F, Alt FW, Monroe RJ, Seidl KJ. Antigen-independent appearance of recombination activating gene (RAG)-positive bone marrow B cells in the spleens of immunized mice. The Journal of Experimental Medicine. 192: 1745-54. PMID 11120771 DOI: 10.1084/Jem.192.12.1745 |
0.436 |
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| 2000 |
Krawczyk C, Bachmaier K, Sasaki T, Jones RG, Snapper SB, Bouchard D, Kozieradzki I, Ohashi PS, Alt FW, Penninger JM. Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells. Immunity. 13: 463-73. PMID 11070165 DOI: 10.1016/S1074-7613(00)00046-7 |
0.346 |
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| 2000 |
Tian M, Alt FW. RNA editing meets DNA shuffling. Nature. 407: 31, 33. PMID 10993058 DOI: 10.1038/35024189 |
0.336 |
|
| 2000 |
Wong KK, Chang S, Weiler SR, Ganesan S, Chaudhuri J, Zhu C, Artandi SE, Rudolph KL, Gottlieb GJ, Chin L, Alt FW, DePinho RA. Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation. Nature Genetics. 26: 85-8. PMID 10973255 DOI: 10.1038/79232 |
0.813 |
|
| 2000 |
O'Hagan RC, Ohh M, David G, de Alboran IM, Alt FW, Kaelin WG, DePinho RA. Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression. Genes & Development. 14: 2185-91. PMID 10970882 DOI: 10.1101/Gad.827200 |
0.531 |
|
| 2000 |
Moores SL, Selfors LM, Fredericks J, Breit T, Fujikawa K, Alt FW, Brugge JS, Swat W. Vav family proteins couple to diverse cell surface receptors. Molecular and Cellular Biology. 20: 6364-73. PMID 10938113 DOI: 10.1128/Mcb.20.17.6364-6373.2000 |
0.314 |
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| 2000 |
Frank KM, Sharpless NE, Gao Y, Sekiguchi JM, Ferguson DO, Zhu C, Manis JP, Horner J, DePinho RA, Alt FW. DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway. Molecular Cell. 5: 993-1002. PMID 10911993 DOI: 10.1016/S1097-2765(00)80264-6 |
0.552 |
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| 2000 |
Chen F, Ma L, Parrini MC, Mao X, Lopez M, Wu C, Marks PW, Davidson L, Kwiatkowski DJ, Kirchhausen T, Orkin SH, Rosen FS, Mayer BJ, Kirschner MW, Alt FW. Cdc42 is required for PIP(2)-induced actin polymerization and early development but not for cell viability. Current Biology : Cb. 10: 758-65. PMID 10898977 DOI: 10.1016/S0960-9822(00)00571-6 |
0.399 |
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| 2000 |
Sleckman BP, Bassing CH, Hughes MM, Okada A, D'Auteuil M, Wehrly TD, Woodman BB, Davidson L, Chen J, Alt FW. Mechanisms that direct ordered assembly of T cell receptor beta locus V, D, and J gene segments. Proceedings of the National Academy of Sciences of the United States of America. 97: 7975-80. PMID 10869424 DOI: 10.1073/Pnas.130190597 |
0.371 |
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| 2000 |
Bassing CH, Alt FW, Hughes MM, D'Auteuil M, Wehrly TD, Woodman BB, Gärtner F, White JM, Davidson L, Sleckman BP. Recombination signal sequences restrict chromosomal V(D)J recombination beyond the 12/23 rule. Nature. 405: 583-6. PMID 10850719 DOI: 10.1038/35014635 |
0.457 |
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| 2000 |
Malynn BA, de Alboran IM, O'Hagan RC, Bronson R, Davidson L, DePinho RA, Alt FW. N-myc can functionally replace c-myc in murine development, cellular growth, and differentiation. Genes & Development. 14: 1390-9. PMID 10837031 DOI: 10.1101/Gad.14.11.1390 |
0.519 |
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| 2000 |
Sleckman BP, Khan WN, Xu W, Bassing CH, Malynn BA, Copeland NG, Bardon CG, Breit TM, Davidson L, Oltz EM, Jenkins NA, Berman JE, Alt FW. Cloning and functional characterization of the early-lymphocyte-specific Pb99 gene. Molecular and Cellular Biology. 20: 4405-10. PMID 10825203 DOI: 10.1128/Mcb.20.12.4405-4410.2000 |
0.419 |
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| 2000 |
Ferguson DO, Sekiguchi JM, Chang S, Frank KM, Gao Y, DePinho RA, Alt FW. The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations. Proceedings of the National Academy of Sciences of the United States of America. 97: 6630-3. PMID 10823907 DOI: 10.1073/Pnas.110152897 |
0.671 |
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| 2000 |
Tian M, Alt FW. Transcription-induced cleavage of immunoglobulin switch regions by nucleotide excision repair nucleases in vitro. The Journal of Biological Chemistry. 275: 24163-72. PMID 10811812 DOI: 10.1074/Jbc.M003343200 |
0.439 |
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| 2000 |
Gao Y, Ferguson DO, Xie W, Manis JP, Sekiguchi J, Frank KM, Chaudhuri J, Horner J, DePinho RA, Alt FW. Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development. Nature. 404: 897-900. PMID 10786799 DOI: 10.1038/35009138 |
0.763 |
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| 2000 |
Gu Y, Sekiguchi J, Gao Y, Dikkes P, Frank K, Ferguson D, Hasty P, Chun J, Alt FW. Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. 97: 2668-73. PMID 10716994 DOI: 10.1073/Pnas.97.6.2668 |
0.593 |
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| 2000 |
Borghesani PR, Alt FW, Bottaro A, Davidson L, Aksoy S, Rathbun GA, Roberts TM, Swat W, Segal RA, Gu Y. Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice. Proceedings of the National Academy of Sciences of the United States of America. 97: 3336-41. PMID 10716718 DOI: 10.1073/Pnas.97.7.3336 |
0.359 |
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| 1999 |
Sekiguchi JM, Gao Y, Gu Y, Frank K, Sun Y, Chaudhuri J, Zhu C, Cheng HL, Manis J, Ferguson D, Davidson L, Greenberg ME, Alt FW. Nonhomologous end-joining proteins are required for V(D)J recombination, normal growth, and neurogenesis. Cold Spring Harbor Symposia On Quantitative Biology. 64: 169-81. PMID 11232282 DOI: 10.1101/Sqb.1999.64.169 |
0.694 |
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| 1999 |
Fruman DA, Snapper SB, Yballe CM, Alt FW, Cantley LC. Phosphoinositide 3-kinase knockout mice: role of p85alpha in B cell development and proliferation. Biochemical Society Transactions. 27: 624-9. PMID 10917654 DOI: 10.1042/Bst0270624 |
0.316 |
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| 1999 |
Monroe RJ, Chen F, Ferrini R, Davidson L, Alt FW. RAG2 is regulated differentially in B and T cells by elements 5' of the promoter. Proceedings of the National Academy of Sciences of the United States of America. 96: 12713-8. PMID 10535988 DOI: 10.1073/Pnas.96.22.12713 |
0.456 |
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| 1999 |
Aifantis I, Pivniouk VI, Gärtner F, Feinberg J, Swat W, Alt FW, von Boehmer H, Geha RS. Allelic exclusion of the T cell receptor beta locus requires the SH2 domain-containing leukocyte protein (SLP)-76 adaptor protein. The Journal of Experimental Medicine. 190: 1093-102. PMID 10523607 DOI: 10.1084/Jem.190.8.1093 |
0.301 |
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| 1999 |
Sakai E, Bottaro A, Alt FW. The Ig heavy chain intronic enhancer core region is necessary and sufficient to promote efficient class switch recombination. International Immunology. 11: 1709-13. PMID 10508189 DOI: 10.1093/Intimm/11.10.1709 |
0.426 |
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| 1999 |
Monroe RJ, Seidl KJ, Gaertner F, Han S, Chen F, Sekiguchi J, Wang J, Ferrini R, Davidson L, Kelsoe G, Alt FW. RAG2:GFP knockin mice reveal novel aspects of RAG2 expression in primary and peripheral lymphoid tissues. Immunity. 11: 201-12. PMID 10485655 DOI: 10.1016/S1074-7613(00)80095-3 |
0.418 |
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| 1999 |
Wang Z, Yunis D, Irigoyen M, Kitchens B, Bottaro A, Alt FW, Alper CA. Discordance between IgA switching at the DNA level and IgA expression at the mRNA level in IgA-deficient patients. Clinical Immunology (Orlando, Fla.). 91: 263-70. PMID 10370371 DOI: 10.1006/Clim.1999.4702 |
0.413 |
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| 1999 |
Gärtner F, Alt FW, Monroe R, Chu M, Sleckman BP, Davidson L, Swat W. Immature thymocytes employ distinct signaling pathways for allelic exclusion versus differentiation and expansion. Immunity. 10: 537-46. PMID 10367899 DOI: 10.1016/S1074-7613(00)80053-9 |
0.356 |
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| 1999 |
Monroe RJ, Sleckman BP, Monroe BC, Khor B, Claypool S, Ferrini R, Davidson L, Alt FW. Developmental regulation of TCR delta locus accessibility and expression by the TCR delta enhancer. Immunity. 10: 503-13. PMID 10367896 DOI: 10.1016/S1074-7613(00)80050-3 |
0.336 |
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| 1999 |
Seidl KJ, Manis JP, Bottaro A, Zhang J, Davidson L, Kisselgof A, Oettgen H, Alt FW. Position-dependent inhibition of class-switch recombination by PGK-neor cassettes inserted into the immunoglobulin heavy chain constant region locus. Proceedings of the National Academy of Sciences of the United States of America. 96: 3000-5. PMID 10077626 DOI: 10.1073/Pnas.96.6.3000 |
0.353 |
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| 1999 |
Shaw AC, Swat W, Davidson L, Alt FW. Induction of Ig light chain gene rearrangement in heavy chain-deficient B cells by activated Ras. Proceedings of the National Academy of Sciences of the United States of America. 96: 2239-43. PMID 10051625 DOI: 10.1073/Pnas.96.5.2239 |
0.422 |
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| 1999 |
Sakai E, Bottaro A, Davidson L, Sleckman BP, Alt FW. Recombination and transcription of the endogenous Ig heavy chain locus is effected by the Ig heavy chain intronic enhancer core region in the absence of the matrix attachment regions. Proceedings of the National Academy of Sciences of the United States of America. 96: 1526-31. PMID 9990057 DOI: 10.1073/Pnas.96.4.1526 |
0.456 |
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| 1999 |
Fruman DA, Snapper SB, Yballe CM, Davidson L, Yu JY, Alt FW, Cantley LC. Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha. Science (New York, N.Y.). 283: 393-7. PMID 9888855 DOI: 10.1126/Science.283.5400.393 |
0.417 |
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| 1999 |
Shaw AC, Swat W, Ferrini R, Davidson L, Alt FW. Activated Ras signals developmental progression of recombinase-activating gene (RAG)-deficient pro-B lymphocytes. The Journal of Experimental Medicine. 189: 123-9. PMID 9874569 DOI: 10.1084/Jem.189.1.123 |
0.391 |
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| 1999 |
Fruman DA, Snapper SB, Yballe CM, Mauvais-Jarvis F, Kahn CR, Alt FW, Cantley LC. PI 3-KINASE KNOCKOUT MICE: ROLE OF p85α IN B CELL DEVELOPMENT AND PROLIFERATION Biochemical Society Transactions. 27: A73-A73. DOI: 10.1042/Bst027A073C |
0.363 |
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| 1998 |
Gao Y, Sun Y, Frank KM, Dikkes P, Fujiwara Y, Seidl KJ, Sekiguchi JM, Rathbun GA, Swat W, Wang J, Bronson RT, Malynn BA, Bryans M, Zhu C, Chaudhuri J, ... ... Alt FW, et al. A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis. Cell. 95: 891-902. PMID 9875844 DOI: 10.1016/S0092-8674(00)81714-6 |
0.735 |
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| 1998 |
Sleckman BP, Bassing CH, Bardon CG, Okada A, Khor B, Bories JC, Monroe R, Alt FW. Accessibility control of variable region gene assembly during T-cell development. Immunological Reviews. 165: 121-30. PMID 9850857 DOI: 10.1111/J.1600-065X.1998.Tb01235.X |
0.35 |
|
| 1998 |
Seidl KJ, Bottaro A, Vo A, Zhang J, Davidson L, Alt FW. An expressed neo(r) cassette provides required functions of the 1gamma2b exon for class switching. International Immunology. 10: 1683-92. PMID 9846697 DOI: 10.1093/Intimm/10.11.1683 |
0.414 |
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| 1998 |
Frank KM, Sekiguchi JM, Seidl KJ, Swat W, Rathbun GA, Cheng HL, Davidson L, Kangaloo L, Alt FW. Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV. Nature. 396: 173-7. PMID 9823897 DOI: 10.1038/24172 |
0.478 |
|
| 1998 |
Sleckman BP, Khor B, Monroe R, Alt FW. Assembly of productive T cell receptor delta variable region genes exhibits allelic inclusion. The Journal of Experimental Medicine. 188: 1465-71. PMID 9782123 DOI: 10.1084/Jem.188.8.1465 |
0.376 |
|
| 1998 |
Manis JP, van der Stoep N, Tian M, Ferrini R, Davidson L, Bottaro A, Alt FW. Class switching in B cells lacking 3' immunoglobulin heavy chain enhancers. The Journal of Experimental Medicine. 188: 1421-31. PMID 9782119 DOI: 10.1084/Jem.188.8.1421 |
0.427 |
|
| 1998 |
Gao Y, Chaudhuri J, Zhu C, Davidson L, Weaver DT, Alt FW. A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination. Immunity. 9: 367-76. PMID 9768756 DOI: 10.1016/S1074-7613(00)80619-6 |
0.703 |
|
| 1998 |
Satterthwaite AB, Lowell CA, Khan WN, Sideras P, Alt FW, Witte ON. Independent and opposing roles for Btk and lyn in B and myeloid signaling pathways. The Journal of Experimental Medicine. 188: 833-44. PMID 9730885 DOI: 10.1084/Jem.188.5.833 |
0.579 |
|
| 1998 |
Cunningham K, Ackerly H, Claflin L, Collins J, Wu P, Ford C, Lansford R, Alt F, Dunnick WA. Germline transcription and recombination of a murine VDJmudeltagamma1 transgene. International Immunology. 10: 1027-37. PMID 9723688 DOI: 10.1093/Intimm/10.8.1027 |
0.421 |
|
| 1998 |
Snapper SB, Rosen FS, Mizoguchi E, Cohen P, Khan W, Liu CH, Hagemann TL, Kwan SP, Ferrini R, Davidson L, Bhan AK, Alt FW. Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation. Immunity. 9: 81-91. PMID 9697838 DOI: 10.1016/S1074-7613(00)80590-7 |
0.414 |
|
| 1998 |
Pivniouk V, Tsitsikov E, Swinton P, Rathbun G, Alt FW, Geha RS. Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76. Cell. 94: 229-38. PMID 9695951 DOI: 10.1016/S0092-8674(00)81422-1 |
0.415 |
|
| 1998 |
Wang LC, Swat W, Fujiwara Y, Davidson L, Visvader J, Kuo F, Alt FW, Gilliland DG, Golub TR, Orkin SH. The TEL/ETV6 gene is required specifically for hematopoiesis in the bone marrow. Genes & Development. 12: 2392-402. PMID 9694803 DOI: 10.1101/Gad.12.15.2392 |
0.32 |
|
| 1998 |
Bottaro A, Young F, Chen J, Serwe M, Sablitzky F, Alt FW. Deletion of the IgH intronic enhancer and associated matrix-attachment regions decreases, but does not abolish, class switching at the mu locus. International Immunology. 10: 799-806. PMID 9678761 DOI: 10.1093/Intimm/10.6.799 |
0.397 |
|
| 1998 |
van der Stoep N, Gorman JR, Alt FW. Reevaluation of 3'Ekappa function in stage- and lineage-specific rearrangement and somatic hypermutation. Immunity. 8: 743-50. PMID 9655488 DOI: 10.1016/S1074-7613(00)80579-8 |
0.448 |
|
| 1998 |
Manis JP, Gu Y, Lansford R, Sonoda E, Ferrini R, Davidson L, Rajewsky K, Alt FW. Ku70 is required for late B cell development and immunoglobulin heavy chain class switching. The Journal of Experimental Medicine. 187: 2081-9. PMID 9625768 DOI: 10.1084/Jem.187.12.2081 |
0.479 |
|
| 1998 |
Swat W, Fujikawa K, Ganiatsas S, Yang D, Xavier RJ, Harris NL, Davidson L, Ferrini R, Davis RJ, Labow MA, Flavell RA, Zon LI, Alt FW. SEK1/MKK4 is required for maintenance of a normal peripheral lymphoid compartment but not for lymphocyte development. Immunity. 8: 625-34. PMID 9620683 DOI: 10.1016/S1074-7613(00)80567-1 |
0.395 |
|
| 1998 |
Cunningham K, Ackerly H, Alt F, Dunnick W. Potential regulatory elements for germline transcription in or near murine Sgamma1. International Immunology. 10: 527-36. PMID 9620609 DOI: 10.1093/Intimm/10.4.527 |
0.349 |
|
| 1998 |
Holsinger LJ, Graef IA, Swat W, Chi T, Bautista DM, Davidson L, Lewis RS, Alt FW, Crabtree GR. Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction. Current Biology : Cb. 8: 563-72. PMID 9601640 DOI: 10.1016/S0960-9822(98)70225-8 |
0.367 |
|
| 1998 |
Lansford R, Manis JP, Sonoda E, Rajewsky K, Alt FW. Ig heavy chain class switching in Rag-deficient mice. International Immunology. 10: 325-32. PMID 9576620 DOI: 10.1093/Intimm/10.3.325 |
0.434 |
|
| 1998 |
Irving BA, Alt FW, Killeen N. Thymocyte development in the absence of pre-T cell receptor extracellular immunoglobulin domains. Science (New York, N.Y.). 280: 905-8. PMID 9572735 DOI: 10.1126/Science.280.5365.905 |
0.335 |
|
| 1998 |
Hata D, Kawakami Y, Inagaki N, Lantz CS, Kitamura T, Khan WN, Maeda-Yamamoto M, Miura T, Han W, Hartman SE, Yao L, Nagai H, Goldfeld AE, Alt FW, Galli SJ, et al. Involvement of Bruton's tyrosine kinase in FcepsilonRI-dependent mast cell degranulation and cytokine production. The Journal of Experimental Medicine. 187: 1235-47. PMID 9547335 DOI: 10.1084/Jem.187.8.1235 |
0.577 |
|
| 1998 |
Ranger AM, Hodge MR, Gravallese EM, Oukka M, Davidson L, Alt FW, de la Brousse FC, Hoey T, Grusby M, Glimcher LH. Delayed lymphoid repopulation with defects in IL-4-driven responses produced by inactivation of NF-ATc. Immunity. 8: 125-34. PMID 9462518 DOI: 10.1016/S1074-7613(00)80465-3 |
0.33 |
|
| 1997 |
Fraefel C, Jacoby DR, Lage C, Hilderbrand H, Chou JY, Alt FW, Breakefield XO, Majzoub JA. Gene transfer into hepatocytes mediated by helper virus-free HSV/AAV hybrid vectors. Molecular Medicine (Cambridge, Mass.). 3: 813-25. PMID 9440115 DOI: 10.1007/Bf03401718 |
0.307 |
|
| 1997 |
Gu Y, Seidl KJ, Rathbun GA, Zhu C, Manis JP, van der Stoep N, Davidson L, Cheng HL, Sekiguchi JM, Frank K, Stanhope-Baker P, Schlissel MS, Roth DB, Alt FW. Growth retardation and leaky SCID phenotype of Ku70-deficient mice. Immunity. 7: 653-65. PMID 9390689 DOI: 10.1016/S1074-7613(00)80386-6 |
0.49 |
|
| 1997 |
Mizuta R, Cheng HL, Gao Y, Alt FW. Molecular genetic characterization of XRCC4 function. International Immunology. 9: 1607-13. PMID 9352367 DOI: 10.1093/Intimm/9.10.1607 |
0.367 |
|
| 1997 |
Gu Y, Jin S, Gao Y, Weaver DT, Alt FW. Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination. Proceedings of the National Academy of Sciences of the United States of America. 94: 8076-81. PMID 9223317 DOI: 10.1073/Pnas.94.15.8076 |
0.483 |
|
| 1997 |
Mizuta R, LaSalle JM, Cheng HL, Shinohara A, Ogawa H, Copeland N, Jenkins NA, Lalande M, Alt FW. RAB22 and RAB163/mouse BRCA2: proteins that specifically interact with the RAD51 protein. Proceedings of the National Academy of Sciences of the United States of America. 94: 6927-32. PMID 9192668 DOI: 10.1073/Pnas.94.13.6927 |
0.351 |
|
| 1997 |
Merrell K, Wells S, Henderson A, Gorman J, Alt F, Stall A, Calame K. The absence of the transcription activator TFE3 impairs activation of B cells in vivo. Molecular and Cellular Biology. 17: 3335-44. PMID 9154832 DOI: 10.1128/Mcb.17.6.3335 |
0.436 |
|
| 1997 |
Kawakami Y, Miura T, Bissonnette R, Hata D, Khan WN, Kitamura T, Maeda-Yamamoto M, Hartman SE, Yao L, Alt FW, Kawakami T. Bruton's tyrosine kinase regulates apoptosis and JNK/SAPK kinase activity. Proceedings of the National Academy of Sciences of the United States of America. 94: 3938-42. PMID 9108083 DOI: 10.1073/Pnas.94.8.3938 |
0.339 |
|
| 1997 |
Khan WN, Nilsson A, Mizoguchi E, Castigli E, Forsell J, Bhan AK, Geha R, Sideras P, Alt FW. Impaired B cell maturation in mice lacking Bruton's tyrosine kinase (Btk) and CD40. International Immunology. 9: 395-405. PMID 9088978 DOI: 10.1093/Intimm/9.3.395 |
0.414 |
|
| 1997 |
Young F, Mizoguchi E, Bhan AK, Alt FW. Constitutive Bcl-2 expression during immunoglobulin heavy chain-promoted B cell differentiation expands novel precursor B cells. Immunity. 6: 23-33. PMID 9052834 DOI: 10.1016/S1074-7613(00)80239-3 |
0.424 |
|
| 1997 |
Willerford DM, Swat W, Alt FW. Developmental regulation of V(D)J recombination and lymphocyte differentiation. Current Opinion in Genetics & Development. 6: 603-9. PMID 8939716 DOI: 10.1016/S0959-437X(96)80090-6 |
0.448 |
|
| 1997 |
Wang Q, Stacy T, Miller JD, Lewis AF, Gu TL, Huang X, Bushweller JH, Bories JC, Alt FW, Ryan G, Liu PP, Wynshaw-Boris A, Binder M, Marín-Padilla M, Sharpe AH, et al. The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo. Cell. 87: 697-708. PMID 8929538 DOI: 10.1016/S0092-8674(00)81389-6 |
0.389 |
|
| 1997 |
Mizuta R, Taccioli GE, Alt FW. The V(D)J recombination defect in the xrs-6 cell line results from a point mutation in the Ku80 gene. International Immunology. 8: 1467-71. PMID 8921425 DOI: 10.1093/Intimm/8.9.1467 |
0.419 |
|
| 1997 |
Komori T, Pricop L, Hatakeyama A, Bona CA, Alt FW. Repertoires of antigen receptors in Tdt congenitally deficient mice. International Reviews of Immunology. 13: 317-25. PMID 8884428 DOI: 10.3109/08830189609061755 |
0.426 |
|
| 1996 |
Dong C, Willerford D, Alt FW, Cooper MD. Genomic organization and chromosomal localization of the mouse Bp3 gene, a member of the CD38/ADP-ribosyl cyclase family Immunogenetics. 45: 35-43. PMID 8881035 DOI: 10.1007/S002510050164 |
0.428 |
|
| 1996 |
Gorman JR, van der Stoep N, Monroe R, Cogne M, Davidson L, Alt FW. The Ig(kappa) enhancer influences the ratio of Ig(kappa) versus Ig(lambda) B lymphocytes. Immunity. 5: 241-52. PMID 8808679 DOI: 10.1016/S1074-7613(00)80319-2 |
0.407 |
|
| 1996 |
Hardin JD, Boast S, Schwartzberg PL, Lee G, Alt FW, Stall AM, Goff SP. Abnormal peripheral lymphocyte function in c-abl mutant mice. Cellular Immunology. 172: 100-7. PMID 8806812 DOI: 10.1006/Cimm.1996.0220 |
0.566 |
|
| 1996 |
Li Z, Alt FW. Identification of the XRCC4 gene: Complementation of the DSBR and V(D)J recombination defects of XR-1 cells Current Topics in Microbiology and Immunology. 217: 143-150. PMID 8787623 DOI: 10.1007/978-3-642-50140-1_10 |
0.348 |
|
| 1996 |
Bories JC, Demengeot J, Davidson L, Alt FW. Gene-targeted deletion and replacement mutations of the T-cell receptor beta-chain enhancer: the role of enhancer elements in controlling V(D)J recombination accessibility. Proceedings of the National Academy of Sciences of the United States of America. 93: 7871-6. PMID 8755569 DOI: 10.1073/Pnas.93.15.7871 |
0.429 |
|
| 1996 |
Sleckman BP, Gorman JR, Alt FW. Accessibility control of antigen-receptor variable-region gene assembly: role of cis-acting elements. Annual Review of Immunology. 14: 459-81. PMID 8717521 DOI: 10.1146/Annurev.Immunol.14.1.459 |
0.351 |
|
| 1996 |
Xu Y, Davidson L, Alt FW, Baltimore D. Function of the pre-T-cell receptor alpha chain in T-cell development and allelic exclusion at the T-cell receptor beta locus. Proceedings of the National Academy of Sciences of the United States of America. 93: 2169-73. PMID 8700903 DOI: 10.1073/Pnas.93.5.2169 |
0.681 |
|
| 1996 |
Porcher C, Swat W, Rockwell K, Fujiwara Y, Alt FW, Orkin SH. The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages. Cell. 86: 47-57. PMID 8689686 DOI: 10.1016/S0092-8674(00)80076-8 |
0.389 |
|
| 1996 |
Castigli E, Young F, Carossino AM, Alt FW, Geha RS. CD40 expression and function in murine B cell ontogeny. International Immunology. 8: 405-411. PMID 8671627 DOI: 10.1093/Intimm/8.3.405 |
0.365 |
|
| 1996 |
Lakso M, Pichel JG, Gorman JR, Sauer B, Okamoto Y, Lee E, Alt FW, Westphal H. Efficient in vivo manipulation of mouse genomic sequences at the zygote stage. Proceedings of the National Academy of Sciences of the United States of America. 93: 5860-5. PMID 8650183 DOI: 10.1073/Pnas.93.12.5860 |
0.386 |
|
| 1996 |
Zhang BW, Zimmer G, Chen J, Ladd D, Li E, Alt FW, Wiederrecht G, Cryan J, O'Neill EA, Seidman CE, Abbas AK, Seidman JG. T cell responses in calcineurin A alpha-deficient mice. The Journal of Experimental Medicine. 183: 413-20. PMID 8627154 DOI: 10.1084/Jem.183.2.413 |
0.331 |
|
| 1996 |
Xu Y, Davidson L, Alt FW, Baltimore D. Deletion of the Ig kappa light chain intronic enhancer/matrix attachment region impairs but does not abolish V kappa J kappa rearrangement. Immunity. 4: 377-85. PMID 8612132 DOI: 10.1016/S1074-7613(00)80251-4 |
0.699 |
|
| 1996 |
Malynn BA, Demengeot J, Stewart V, Charron J, Alt FW. Generation of normal lymphocytes derived from N-myc-deficient embryonic stem cells. International Immunology. 7: 1637-47. PMID 8562509 DOI: 10.1093/Intimm/7.10.1637 |
0.442 |
|
| 1996 |
Taccioli GE, Alt FW. Potential targets for autosomal SCID mutations. Current Opinion in Immunology. 7: 436-40. PMID 7495505 DOI: 10.1016/0952-7915(95)80085-9 |
0.383 |
|
| 1995 |
Demengeot J, Oltz EM, Alt FW. Promotion of V(D)J recombinational accessibility by the intronic E kappa element: role of the kappa B motif. International Immunology. 7: 1995-2003. PMID 8746569 DOI: 10.1093/Intimm/7.12.1995 |
0.383 |
|
| 1995 |
Blunt T, Taccioli GE, Priestley A, Hafezparast M, McMillan T, Liu J, Cole CC, White J, Alt FW, Jackson SP, Schurr E, Lehmann AR, Jeggo PA. A YAC Contig Encompassing the XRCC5 (Ku80) DNA Repair Gene and Complementation of Defective Cells by YAC Protoplast Fusion Genomics. 30: 320-328. PMID 8586433 DOI: 10.1006/Geno.1995.9871 |
0.457 |
|
| 1995 |
Li Z, Otevrel T, Gao Y, Cheng HL, Seed B, Stamato TD, Taccioli GE, Alt FW. The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination. Cell. 83: 1079-89. PMID 8548796 DOI: 10.1016/0092-8674(95)90135-3 |
0.482 |
|
| 1995 |
Chen J, Ma A, Young F, Alt FW. IL-2 receptor alpha chain expression during early B lymphocyte differentiation. International Immunology. 6: 1265-8. PMID 7981152 DOI: 10.1093/Intimm/6.8.1265 |
0.323 |
|
| 1995 |
Blunt T, Finnie NJ, Taccioli GE, Smith GCM, Demengeot J, Gottlieb TM, Mizuta R, Varghese AJ, Alt FW, Jeggo PA, Jackson SP. Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation Cell. 80: 813-823. PMID 7889575 DOI: 10.1016/0092-8674(95)90360-7 |
0.452 |
|
| 1995 |
Chen J, Stewart V, Spyrou G, Hilberg F, Wagner EF, Alt FW. Generation of normal T and B lymphocytes by c-jun deficient embryonic stem cells. Immunity. 1: 65-72. PMID 7889400 DOI: 10.1016/1074-7613(94)90010-8 |
0.403 |
|
| 1995 |
Ma A, Pena JC, Chang B, Margosian E, Davidson L, Alt FW, Thompson CB. Bclx regulates the survival of double-positive thymocytes. Proceedings of the National Academy of Sciences of the United States of America. 92: 4763-7. PMID 7761398 DOI: 10.1073/Pnas.92.11.4763 |
0.305 |
|
| 1995 |
Zhang R, Alt FW, Davidson L, Orkin SH, Swat W. Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene. Nature. 374: 470-3. PMID 7700359 DOI: 10.1038/374470A0 |
0.401 |
|
| 1995 |
Hardin JD, Boast S, Schwartzberg PL, Lee G, Alt FW, Stall AM, Goff SP. Bone marrow B lymphocyte development in c-abl-deficient mice. Cellular Immunology. 165: 44-54. PMID 7671324 DOI: 10.1006/Cimm.1995.1185 |
0.575 |
|
| 1995 |
Willerford DM, Chen J, Ferry JA, Davidson L, Ma A, Alt FW. Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. Immunity. 3: 521-30. PMID 7584142 DOI: 10.1016/1074-7613(95)90180-9 |
0.329 |
|
| 1995 |
Zhang Y, Cado D, Asarnow DM, Komori T, Alt FW, Raulet DH, Allison JP. The role of short homology repeats and TdT in generation of the invariant gamma delta antigen receptor repertoire in the fetal thymus. Immunity. 3: 439-47. PMID 7584135 DOI: 10.1016/1074-7613(95)90173-6 |
0.384 |
|
| 1995 |
Bories JC, Willerford DM, Grévin D, Davidson L, Camus A, Martin P, Stéhelin D, Alt FW. Increased T-cell apoptosis and terminal B-cell differentiation induced by inactivation of the Ets-1 proto-oncogene. Nature. 377: 635-8. PMID 7566176 DOI: 10.1038/377635A0 |
0.402 |
|
| 1995 |
Khan WN, Alt FW, Gerstein RM, Malynn BA, Larsson I, Rathbun G, Davidson L, Müller S, Kantor AB, Herzenberg LA, Rosen FS, Sideras P. Defective B cell development and function in Btk-deficient mice Immunity. 3: 283-299. PMID 7552994 DOI: 10.1016/1074-7613(95)90114-0 |
0.445 |
|
| 1995 |
Castigli E, Alt FW, Davidson L, Bottaro A, Mizoguchi E, Bhan AK, Geha RS. CD40-deficient mice generated by recombination-activating gene-2-deficient blastocyst complementation. Proceedings of the National Academy of Sciences of the United States of America. 91: 12135-9. PMID 7527552 DOI: 10.1073/Pnas.91.25.12135 |
0.349 |
|
| 1995 |
Khan WN, Sideras P, Rosen FS, Alt FW. The role of Bruton's tyrosine kinase in B-cell development and function in mice and man Annals of the New York Academy of Sciences. 764: 27-38. PMID 7486535 DOI: 10.1111/J.1749-6632.1995.Tb55802.X |
0.361 |
|
| 1994 |
Cogné M, Lansford R, Bottaro A, Zhang J, Gorman J, Young F, Cheng HL, Alt FW. A class switch control region at the 3' end of the immunoglobulin heavy chain locus. Cell. 77: 737-47. PMID 8205622 DOI: 10.1016/0092-8674(94)90057-4 |
0.433 |
|
| 1994 |
Karasuyama H, Relink A, Shinkai Y, Young F, Alt FW, Melchers F. The expression of Vpre-B/λ5 surrogate light chain in early bone marrow precursor B cells of normal and B cell-deficient mutant mice Cell. 77: 133-143. PMID 8156589 DOI: 10.1016/0092-8674(94)90241-0 |
0.414 |
|
| 1994 |
Tsai FY, Keller G, Kuo FC, Weiss M, Chen J, Rosenblatt M, Alt FW, Orkin SH. An early haematopoietic defect in mice lacking the transcription factor GATA-2. Nature. 371: 221-6. PMID 8078582 DOI: 10.1038/371221A0 |
0.371 |
|
| 1994 |
Taccioli GE, Gottlieb TM, Blunt T, Priestley A, Demengeot J, Mizuta R, Lehmann AR, Alt FW, Jackson SP, Jeggo PA. Ku80: Product of the XRCC5 gene and its role in DNA repair and V(D)J recombination Science. 265: 1442-1445. PMID 8073286 DOI: 10.1126/Science.8073286 |
0.429 |
|
| 1994 |
Li SC, Rothman PB, Zhang J, Chan C, Hirsh D, Alt FW. Expression of I mu-C gamma hybrid germline transcripts subsequent to immunoglobulin heavy chain class switching. International Immunology. 6: 491-7. PMID 8018590 DOI: 10.1093/Intimm/6.4.491 |
0.35 |
|
| 1994 |
Chen J, Shinkai Y, Young F, Alt FW. Probing immune functions in RAG-deficient mice. Current Opinion in Immunology. 6: 313-9. PMID 8011215 DOI: 10.1016/0952-7915(94)90107-4 |
0.419 |
|
| 1994 |
Okada A, Mendelsohn M, Alt F. Differential activation of transcription versus recombination of transgenic T cell receptor beta variable region gene segments in B and T lineage cells. The Journal of Experimental Medicine. 180: 261-72. PMID 8006587 DOI: 10.1084/Jem.180.1.261 |
0.345 |
|
| 1994 |
Isobe H, Alt F, Bona CA, Schulman J. Intact antiinfluenza virus immune response in targeted kappa-deficient mice. Viral Immunology. 7: 25-30. PMID 7986333 DOI: 10.1089/Vim.1994.7.25 |
0.328 |
|
| 1994 |
Sen J, Shinkai Y, Alt FW, Sen R, Burakoff SJ. Nuclear factors that mediate intrathymic signals are developmentally regulated Journal of Experimental Medicine. 180: 2321-2327. PMID 7964504 DOI: 10.1084/Jem.180.6.2321 |
0.318 |
|
| 1994 |
Okada A, Alt FW. Mechanisms that control antigen receptor variable region gene assembly. Seminars in Immunology. 6: 185-96. PMID 7948958 DOI: 10.1006/Smim.1994.1024 |
0.394 |
|
| 1994 |
Young F, Ardman B, Shinkai Y, Lansford R, Blackwell TK, Mendelsohn M, Rolink A, Melchers F, Alt FW. Influence of immunoglobulin heavy- and light-chain expression on B-cell differentiation Genes and Development. 8: 1043-1057. PMID 7926786 DOI: 10.1101/Gad.8.9.1043 |
0.449 |
|
| 1994 |
Pricop L, Brumeanu T, Elahi E, Moran T, Wang BS, Troustine M, Huszar D, Alt F, Bona C. Antibody response elicited by T-dependent and T-independent antigens in gene targeted kappa-deficient mice. International Immunology. 6: 1839-47. PMID 7535094 DOI: 10.1093/Intimm/6.12.1839 |
0.345 |
|
| 1994 |
Kojima H, Shinohara N, Hanaoka S, Someya-Shirota Y, Takagaki Y, Ohno H, Saito T, Katayama T, Yagita H, Okumura K, Shinkai Y, Alt FW, Matsuzawa A, Yonehara S, Takayama H. Two distinct pathways of specific killing revealed by perforin mutant cytotoxic T lymphocytes. Immunity. 1: 357-364. PMID 7533644 DOI: 10.1016/1074-7613(94)90066-3 |
0.412 |
|
| 1994 |
Bottaro A, Lansford R, Xu L, Zhang J, Rothman P, Alt F. S region transcription per se promotes basal IgE class switch recombination but additional factors regulate the efficiency of the process. The Embo Journal. 13: 665-674. DOI: 10.1002/J.1460-2075.1994.Tb06305.X |
0.386 |
|
| 1993 |
Chen J, Alt FW. Gene rearrangement and B-cell development. Current Opinion in Immunology. 5: 194-200. PMID 8507397 DOI: 10.1016/0952-7915(93)90004-C |
0.413 |
|
| 1993 |
Chen J, Lansford R, Stewart V, Young F, Alt FW. RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development. Proceedings of the National Academy of Sciences of the United States of America. 90: 4528-32. PMID 8506294 DOI: 10.1073/Pnas.90.10.4528 |
0.457 |
|
| 1993 |
Xu L, Gorham B, Li SC, Bottaro A, Alt FW, Rothman P. Replacement of germ-line epsilon promoter by gene targeting alters control of immunoglobulin heavy chain class switching. Proceedings of the National Academy of Sciences of the United States of America. 90: 3705-9. PMID 8475119 DOI: 10.1073/Pnas.90.8.3705 |
0.353 |
|
| 1993 |
Taccioli GE, Rathbun G, Oltz E, Stamato T, Jeggo PA, Alt FW. Impairment of V(D)J recombination in double-strand break repair mutants Science. 260: 207-210. PMID 8469973 DOI: 10.1126/Science.8469973 |
0.463 |
|
| 1993 |
Chen J, Trounstine M, Kurahara C, Young F, Kuo CC, Xu Y, Loring JF, Alt FW, Huszar D. B cell development in mice that lack one or both immunoglobulin kappa light chain genes. The Embo Journal. 12: 821-30. PMID 8458340 DOI: 10.1002/J.1460-2075.1993.Tb05722.X |
0.565 |
|
| 1993 |
Shinkai Y, Koyasu S, Nakayama KI, Murphy KM, Loh DY, Reinherz EL, Alt FW. Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes Science. 259: 822-825. PMID 8430336 DOI: 10.1126/Science.8430336 |
0.319 |
|
| 1993 |
Oltz EM, Alt FW, Lin WC, Chen J, Taccioli G, Desiderio S, Rathbun G. A V(D)J recombinase-inducible B-cell line: role of transcriptional enhancer elements in directing V(D)J recombination. Molecular and Cellular Biology. 13: 6223-30. PMID 8413222 DOI: 10.1128/Mcb.13.10.6223 |
0.685 |
|
| 1993 |
Rathbun G, Oltz EM, Alt FW. Comparison of RAG gene expression in normal and transformed precursor lymphocytes. International Immunology. 5: 997-1000. PMID 8398992 DOI: 10.1093/Intimm/5.8.997 |
0.413 |
|
| 1993 |
Nakayama KI, Nakayama K, Negishi I, Kuida K, Shinkai Y, Louie MC, Fields LE, Lucas PJ, Stewart V, Alt FW, Loh DY. Disappearance of the lymphoid system in bcl-2 homozygous mutant chimeric mice Science. 261: 1584-1588. PMID 8372353 DOI: 10.1126/Science.8372353 |
0.376 |
|
| 1993 |
Komori T, Okada A, Stewart V, Alt FW. Lack of N regions in antigen receptor variable region genes of TdT-deficient lymphocytes. Science (New York, N.Y.). 261: 1171-5. PMID 8356451 DOI: 10.1126/Science.8356451 |
0.367 |
|
| 1993 |
Chen J, Trounstine M, Alt FW, Young F, Kurahara C, Loring JF, Huszar D. Immunoglobulin gene rearrangement in B cell deficient mice generated by targeted deletion of the JH locus. International Immunology. 5: 647-56. PMID 8347558 DOI: 10.1093/Intimm/5.6.647 |
0.418 |
|
| 1993 |
Xu Y, Baldassare M, Fisher P, Rathbun G, Oltz EM, Yancopoulos GD, Jessell TM, Alt FW. LH-2: a LIM/homeodomain gene expressed in developing lymphocytes and neural cells. Proceedings of the National Academy of Sciences of the United States of America. 90: 227-31. PMID 7678338 DOI: 10.1073/Pnas.90.1.227 |
0.633 |
|
| 1993 |
Charron J, Malynn BA, Fisher P, Stewart V, Jeannotte L, Goff SP, Robertson EJ, Alt FW. Embryonic lethality in mice homozygous for a targeted disruption of the N-myc gene. Genes & Development. 6: 2248-57. PMID 1459450 DOI: 10.1101/Gad.6.12A.2248 |
0.535 |
|
| 1993 |
Chen J, Young F, Bottaro A, Stewart V, Smith R, Alt F. Mutations of the intronic IgH enhancer and its flanking sequences differentially affect accessibility of the JH locus. The Embo Journal. 12: 4635-4645. DOI: 10.1002/J.1460-2075.1993.Tb06152.X |
0.421 |
|
| 1993 |
Zhang J, Bottaro A, Li S, Stewart V, Alt F. A selective defect in IgG2b switching as a result of targeted mutation of the I gamma 2b promoter and exon. The Embo Journal. 12: 3529-3537. DOI: 10.1002/J.1460-2075.1993.Tb06027.X |
0.457 |
|
| 1992 |
Morrow MA, Lee G, Gillis S, Yancopoulos GD, Alt FW. Interleukin-7 induces N-myc and c-myc expression in normal precursor B lymphocytes. Genes & Development. 6: 61-70. PMID 1730410 DOI: 10.1101/Gad.6.1.61 |
0.543 |
|
| 1992 |
Oltz EM, Yancopoulos GD, Morrow MA, Rolink A, Lee G, Wong F, Kaplan K, Gillis S, Melchers F, Alt FW. A novel regulatory myosin light chain gene distinguishes pre-B cell subsets and is IL-7 inducible. The Embo Journal. 11: 2759-67. PMID 1628631 DOI: 10.1002/J.1460-2075.1992.Tb05341.X |
0.558 |
|
| 1992 |
Alt FW, Rathbun G, Oltz E, Taccioli G, Shinkai Y. Function and control of recombination-activating gene activity. Annals of the New York Academy of Sciences. 651: 277-94. PMID 1599127 DOI: 10.1111/J.1749-6632.1992.Tb24626.X |
0.433 |
|
| 1992 |
Smith RK, Zimmerman K, Yancopoulos GD, Ma A, Alt FW. Transcriptional down-regulation of N-myc expression during B-cell development. Molecular and Cellular Biology. 12: 1578-84. PMID 1549113 DOI: 10.1128/Mcb.12.4.1578 |
0.571 |
|
| 1992 |
Taccioli GE, Rathbun G, Shinkai Y, Oltz EM, Cheng H, Whitmore G, Stamato T, Jeggo P, Alt FW. Activities involved in V(D)J recombination. Current Topics in Microbiology and Immunology. 182: 107-14. PMID 1490344 DOI: 10.1007/978-3-642-77633-5_13 |
0.378 |
|
| 1992 |
Alt FW, Kellems RE, Bertino JR, Schimke RT. Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells. 1978. Biotechnology (Reading, Mass.). 24: 397-410. PMID 1422048 |
0.483 |
|
| 1992 |
Möröy T, Fisher PE, Lee G, Achacoso P, Wiener F, Alt FW. High frequency of myelomonocytic tumors in aging Eμ L-myc transgenic mice Journal of Experimental Medicine. 175: 313-322. PMID 1310099 DOI: 10.1084/Jem.175.2.313 |
0.347 |
|
| 1992 |
Ma A, Fisher P, Dildrop R, Oltz E, Rathbun G, Achacoso P, Stall A, Alt F. Surface IgM mediated regulation of RAG gene expression in E mu-N-myc B cell lines. The Embo Journal. 11: 2727-2734. DOI: 10.1002/J.1460-2075.1992.Tb05338.X |
0.432 |
|
| 1991 |
Alt FW, Rathbun G, Yancopoulos GD. DNA recombination in the brain? Current Biology : Cb. 1: 3-5. PMID 15336189 DOI: 10.1016/0960-9822(91)90108-9 |
0.502 |
|
| 1991 |
Rothman P, Lutzker S, Gorham B, Stewart V, Coffman R, Alt FW. Structure and expression of germline immunoglobulin gamma 3 heavy chain gene transcripts: implications for mitogen and lymphokine directed class-switching. International Immunology. 2: 621-7. PMID 2126196 DOI: 10.1093/Intimm/2.7.621 |
0.402 |
|
| 1991 |
Covey LR, Ferrier P, Alt FW. VH to VHDJH rearrangement is mediated by the internal VH heptamer. International Immunology. 2: 579-83. PMID 2085492 DOI: 10.1093/Intimm/2.6.579 |
0.409 |
|
| 1991 |
Collum RG, Clayton DF, Alt FW. Structure and expression of canary myc family genes Molecular and Cellular Biology. 11: 1770-1776. PMID 1996121 DOI: 10.1128/Mcb.11.3.1770 |
0.317 |
|
| 1991 |
Ma A, Smith RK, Tesfaye A, Achacoso P, Dildrop R, Rosenberg N, Alt FW. Mechanism of endogenous myc gene down-regulation in E mu-N-myc tumors. Molecular and Cellular Biology. 11: 440-4. PMID 1986238 DOI: 10.1128/Mcb.11.1.440 |
0.337 |
|
| 1991 |
Li SC, Rothman P, Boothby M, Ferrier P, Glimcher L, Alt FW. Control of immunoglobulin heavy chain constant region gene expression. Advances in Experimental Medicine and Biology. 292: 245-51. PMID 1950776 DOI: 10.1007/978-1-4684-5943-2_27 |
0.4 |
|
| 1991 |
DePinho RA, Schreiber-Agus N, Alt FW. myc family oncogenes in the development of normal and neoplastic cells. Advances in Cancer Research. 57: 1-46. PMID 1950701 DOI: 10.1016/S0065-230X(08)60994-X |
0.527 |
|
| 1991 |
Timmers E, de Weers M, Alt FW, Hendriks RW, Schuurman RK. X-linked agammaglobulinemia. Clinical Immunology and Immunopathology. 61: S83-93. PMID 1934617 DOI: 10.1016/S0090-1229(05)80042-X |
0.467 |
|
| 1991 |
Rothman P, Li SC, Gorham B, Glimcher L, Alt F, Boothby M. Identification of a conserved lipopolysaccharide-plus-interleukin-4-responsive element located at the promoter of germ line epsilon transcripts. Molecular and Cellular Biology. 11: 5551-61. PMID 1922063 DOI: 10.1128/Mcb.11.11.5551 |
0.416 |
|
| 1991 |
Timmers E, Kenter M, Thompson A, Kraakman ME, Berman JE, Alt FW, Schuurman RK. Diversity of immunoglobulin heavy chain gene segment rearrangement in B lymphoblastoid cell lines from X-linked agammaglobulinemia patients. European Journal of Immunology. 21: 2355-63. PMID 1915549 DOI: 10.1002/Eji.1830211010 |
0.431 |
|
| 1991 |
Bailey NC, Kasturi KN, Blackwell TK, Alt FW, Bona CA. Complexity of the immunoglobulin light chain V kappa 1 gene family in the New Zealand black mouse. International Immunology. 3: 751-60. PMID 1911544 DOI: 10.1093/Intimm/3.8.751 |
0.346 |
|
| 1991 |
Berman JE, Nickerson KG, Pollock RR, Barth JE, Schuurman RK, Knowles DM, Chess L, Alt FW. VH gene usage in humans: biased usage of the VH6 gene in immature B lymphoid cells. European Journal of Immunology. 21: 1311-4. PMID 1903708 DOI: 10.1002/Eji.1830210532 |
0.384 |
|
| 1991 |
Berman JE, Humphries CG, Barth J, Alt FW, Tucker PW. Structure and expression of human germline VH transcripts. The Journal of Experimental Medicine. 173: 1529-35. PMID 1903431 DOI: 10.1084/Jem.173.6.1529 |
0.384 |
|
| 1991 |
Bailey NC, Bona A, Dikman S, Bonilla F, Alt FW, Bona C. Correlation between the occurrence of lupus nephritis, anti-erythrocyte autoantibodies and V kappa haplotype in NZB x 129/J and NZB x SM/J recombinant inbred murine strains. European Journal of Immunology. 21: 959-65. PMID 1902180 DOI: 10.1002/Eji.1830210415 |
0.356 |
|
| 1990 |
Blackwell TK, Alt FW. Mechanism and developmental program of immunoglobulin gene rearrangement in mammals. Annual Review of Genetics. 23: 605-36. PMID 2694945 DOI: 10.1146/Annurev.Ge.23.120189.003133 |
0.391 |
|
| 1990 |
Yancopoulos GD, Nolan GP, Pollock R, Prockop S, Li SC, Herzenberg LA, Alt FW. A novel fluorescence-based system for assaying and separating live cells according to VDJ recombinase activity. Molecular and Cellular Biology. 10: 1697-704. PMID 2320007 DOI: 10.1128/mcb.10.4.1697-1704.1990 |
0.554 |
|
| 1990 |
Malynn BA, Yancopoulos GD, Barth JE, Bona CA, Alt FW. Biased expression of JH-proximal VH genes occurs in the newly generated repertoire of neonatal and adult mice. The Journal of Experimental Medicine. 171: 843-59. PMID 2261012 DOI: 10.1084/Jem.171.3.843 |
0.532 |
|
| 1990 |
Zimmerman K, Legouy E, Stewart V, Depinho R, Alt FW. Differential regulation of the N-myc gene in transfected cells and transgenic mice. Molecular and Cellular Biology. 10: 2096-103. PMID 2183019 DOI: 10.1128/Mcb.10.5.2096 |
0.534 |
|
| 1990 |
Charron J, Malynn BA, Robertson EJ, Goff SP, Alt FW. High-frequency disruption of the N-myc gene in embryonic stem and pre-B cell lines by homologous recombination. Molecular and Cellular Biology. 10: 1799-804. PMID 2181287 DOI: 10.1128/Mcb.10.4.1799 |
0.566 |
|
| 1990 |
Rothman P, Chen YY, Lutzker S, Li SC, Stewart V, Coffman R, Alt FW. Structure and expression of germ line immunoglobulin heavy-chain epsilon transcripts: interleukin-4 plus lipopolysaccharide-directed switching to C epsilon. Molecular and Cellular Biology. 10: 1672-9. PMID 2157139 DOI: 10.1128/Mcb.10.4.1672 |
0.377 |
|
| 1990 |
Ferrier P, Krippl B, Blackwell TK, Furley AJ, Suh H, Winoto A, Cook WD, Hood L, Costantini F, Alt FW. Separate elements control DJ and VDJ rearrangement in a transgenic recombination substrate. The Embo Journal. 9: 117-25. PMID 2153073 DOI: 10.1002/J.1460-2075.1990.Tb08087.X |
0.421 |
|
| 1990 |
Berman JE, Alt FW. Human heavy chain variable region gene diversity, organization, and expression. International Reviews of Immunology. 5: 203-14. PMID 2130117 DOI: 10.3109/08830189009056729 |
0.332 |
|
| 1990 |
Ferrier P, Covey LR, Li SC, Suh H, Malynn BA, Blackwell TK, Morrow MA, Alt FW. Normal recombination substrate VH to DJH rearrangements in pre-B cell lines from scid mice. The Journal of Experimental Medicine. 171: 1909-18. PMID 2112584 DOI: 10.1084/Jem.171.6.1909 |
0.43 |
|
| 1990 |
Desai R, Spatz L, Matsuda T, Ilyas AA, Berman JE, Alt FW, Kabat EA, Latov N. Molecular cloning of a human immunoglobulin heavy chain variable (VH) region with anti-myelin-associated glycoprotein activity. Journal of Neuroimmunology. 26: 35-41. PMID 1688442 DOI: 10.1016/0165-5728(90)90117-6 |
0.382 |
|
| 1990 |
Möröy T, Fisher P, Guidos C, Ma A, Zimmerman K, Tesfaye A, DePinho R, Weissman I, Alt FW. IgH enhancer deregulated expression of L-myc: abnormal T lymphocyte development and T cell lymphomagenesis. The Embo Journal. 9: 3659-3666. DOI: 10.1002/J.1460-2075.1990.Tb07577.X |
0.539 |
|
| 1989 |
Rothman P, Lutzker S, Cook W, Coffman R, Alt FW. Mitogen plus interleukin 4 induction of C epsilon transcripts in B lymphoid cells. The Journal of Experimental Medicine. 168: 2385-9. PMID 3264328 DOI: 10.1084/Jem.168.6.2385 |
0.349 |
|
| 1989 |
Alt FW, Ferrier P, Malynn B, Lutzker S, Rothman P, Berman J, Blackwell K, Mellis S, Pollock R, Furley A. Control of recombination events during lymphocyte differentiation. Heavy chain variable region gene assembly and heavy chain class switching. Annals of the New York Academy of Sciences. 546: 9-24. PMID 3150262 DOI: 10.1111/J.1749-6632.1988.Tb21614.X |
0.383 |
|
| 1989 |
Blackwell TK, Malynn BA, Pollock RR, Ferrier P, Covey LR, Fulop GM, Phillips RA, Yancopoulos GD, Alt FW. Isolation of scid pre-B cells that rearrange kappa light chain genes: formation of normal signal and abnormal coding joins. The Embo Journal. 8: 735-42. PMID 2785917 DOI: 10.1002/J.1460-2075.1989.Tb03433.X |
0.586 |
|
| 1989 |
Rathbun G, Alt FW, Yancopoulos GD. Immunology: making antigen-receptor genes. Nature. 342: 863-4. PMID 2594082 DOI: 10.1038/342863A0 |
0.472 |
|
| 1989 |
Logtenberg T, Schutte ME, Inghirami G, Berman JE, Gmelig-Meyling FH, Insel RA, Knowles DM, Alt FW. Immunoglobulin VH gene expression in human B cell lines and tumors: biased VH gene expression in chronic lymphocytic leukemia. International Immunology. 1: 362-6. PMID 2562243 DOI: 10.1093/Intimm/1.4.362 |
0.398 |
|
| 1989 |
Ferrier P, Covey LR, Suh H, Winoto A, Hood L, Alt FW. T cell receptor DJ but not VDJ rearrangement within a recombination substrate introduced into a pre-B cell line. International Immunology. 1: 66-74. PMID 2562155 DOI: 10.1093/Intimm/1.1.66 |
0.328 |
|
| 1989 |
Logtenberg T, Young FM, van Es J, Gmelig-Meyling FH, Berman JE, Alt FW. Frequency of VH-gene utilization in human EBV-transformed B-cell lines: the most JH-proximal VH segment encodes autoantibodies. Journal of Autoimmunity. 2: 203-13. PMID 2550019 DOI: 10.1016/0896-8411(89)90132-7 |
0.377 |
|
| 1989 |
Nickerson KG, Berman J, Glickman E, Chess L, Alt FW. Early human IgH gene assembly in Epstein-Barr virus-transformed fetal B cell lines. Preferential utilization of the most J(H)-proximal D segment (DQ52) and two unusual V(H)-related rearrangements Journal of Experimental Medicine. 169: 1391-1403. PMID 2538551 DOI: 10.1084/Jem.169.4.1391 |
0.358 |
|
| 1989 |
Hsu E, Schwager J, Alt FW. Evolution of immunoglobulin genes: VH families in the amphibian Xenopus. Proceedings of the National Academy of Sciences of the United States of America. 86: 8010-4. PMID 2510156 DOI: 10.1073/Pnas.86.20.8010 |
0.342 |
|
| 1989 |
Logtenberg T, Young FM, Van Es JH, Gmelig-Meyling FH, Alt FW. Autoantibodies encoded by the most Jh-proximal human immunoglobulin heavy chain variable region gene. The Journal of Experimental Medicine. 170: 1347-55. PMID 2507728 DOI: 10.1084/Jem.170.4.1347 |
0.373 |
|
| 1989 |
Logtenberg T, Schutte M, van Es J, Gmelig-Meyling F, Alt F. Frequency of VH gene utilization in human B cell populations: Correlations with autoantibody specificities Cell Differentiation and Development. 27: 63. DOI: 10.1016/0922-3371(89)90217-7 |
0.348 |
|
| 1989 |
Dildrop R, Ma A, Zimmerman K, Hsu E, Tesfaye A, DePinho R, Alt FW. IgH enhancer-mediated deregulation of N-myc gene expression in transgenic mice: generation of lymphoid neoplasias that lack c-myc expression. The Embo Journal. 8: 1121-1128. DOI: 10.1002/J.1460-2075.1989.Tb03482.X |
0.537 |
|
| 1988 |
Yancopoulos GD, Alt FW. Reconstruction of an immune system. Science (New York, N.Y.). 241: 1581-3. PMID 3262236 DOI: 10.1126/Science.3262236 |
0.414 |
|
| 1988 |
Dildrop R, Zimmerman K, DePinho RA, Yancopoulos GD, Tesfaye A, Alt FW. Differential expression of myc-family genes during development: normal and deregulated N-myc expression in transgenic mice. Current Topics in Microbiology and Immunology. 141: 100-9. PMID 3215042 DOI: 10.1007/978-3-642-74006-0_14 |
0.585 |
|
| 1988 |
Malynn BA, Blackwell TK, Fulop GM, Rathbun GA, Furley AJ, Ferrier P, Heinke LB, Phillips RA, Yancopoulos GD, Alt FW. The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism. Cell. 54: 453-60. PMID 3135938 DOI: 10.1016/0092-8674(88)90066-9 |
0.587 |
|
| 1988 |
Yancopoulos GD, Malynn BA, Alt FW. Developmentally regulated and strain-specific expression of murine VH gene families. The Journal of Experimental Medicine. 168: 417-35. PMID 3135366 DOI: 10.1084/Jem.168.1.417 |
0.518 |
|
| 1988 |
Lutzker S, Alt FW. Structure and expression of germ line immunoglobulin gamma 2b transcripts. Molecular and Cellular Biology. 8: 1849-52. PMID 3132612 DOI: 10.1128/Mcb.8.4.1849 |
0.392 |
|
| 1988 |
Takihara Y, Champagne E, Griesser H, Kimura N, Tkachuk D, Reimann J, Okada A, Alt FW, Chess L, Minden M. Sequence and organization of the human T cell delta chain gene. European Journal of Immunology. 18: 283-7. PMID 2965024 DOI: 10.1002/Eji.1830180216 |
0.384 |
|
| 1988 |
Okada A, Bank I, Rogozinski L, Takihara Y, Mak TW, Chess L, Alt FW. Structure of the gamma/delta T cell receptor of a human thymocyte clone. The Journal of Experimental Medicine. 168: 1481-6. PMID 2844954 DOI: 10.1084/Jem.168.4.1481 |
0.337 |
|
| 1988 |
Lutzker S, Rothman P, Pollock R, Coffman R, Alt FW. Mitogen- and IL-4-regulated expression of germ-line Ig gamma 2b transcripts: evidence for directed heavy chain class switching. Cell. 53: 177-84. PMID 2834063 DOI: 10.1016/0092-8674(88)90379-0 |
0.392 |
|
| 1987 |
Bellon B, Manheimer-Lory A, Monestier M, Moran T, Dimitriu-Bona A, Alt F, Bona C. High frequency of autoantibodies bearing cross-reactive idiotopes among hybridomas using V(H)7183 genes prepared from normal and autoimmune murine strains Journal of Clinical Investigation. 79: 1044-1053. PMID 3558816 DOI: 10.1172/Jci112917 |
0.32 |
|
| 1987 |
Maddon PJ, Molineaux SM, Maddon DE, Zimmerman KA, Godfrey M, Alt FW, Chess L, Axel R. Structure and expression of the human and mouse T4 genes. Proceedings of the National Academy of Sciences of the United States of America. 84: 9155-9. PMID 3501122 DOI: 10.1073/Pnas.84.24.9155 |
0.589 |
|
| 1987 |
DePinho RA, Hatton KS, Tesfaye A, Yancopoulos GD, Alt FW. The human myc gene family: structure and activity of L-myc and an L-myc pseudogene. Genes & Development. 1: 1311-26. PMID 3322939 DOI: 10.1101/Gad.1.10.1311 |
0.605 |
|
| 1987 |
Alt FW, Blackwell TK, Yancopoulos GD. Development of the primary antibody repertoire. Science (New York, N.Y.). 238: 1079-87. PMID 3317825 DOI: 10.1126/Science.3317825 |
0.504 |
|
| 1987 |
Malynn BA, Berman JE, Yancopoulos GD, Bona CA, Alt FW. Expression of the immunoglobulin heavy-chain variable gene repertoire. Current Topics in Microbiology and Immunology. 135: 75-94. PMID 3107914 DOI: 10.1007/978-3-642-71851-9_6 |
0.52 |
|
| 1987 |
Alt FW, Yancopoulos GD. Circular T-cell receptor gene recombination products. Nature. 327: 189-90. PMID 3106830 DOI: 10.1038/327189A0 |
0.509 |
|
| 1987 |
Legouy E, DePinho R, Zimmerman K, Collum R, Yancopoulos G, Mitsock L, Kriz R, Alt FW. Structure and expression of the murine L-myc gene. The Embo Journal. 6: 3359-66. PMID 2828024 |
0.578 |
|
| 1987 |
Ott D, Alt F, Marcu K. Immunoglobulin heavy chain switch region recombination within a retroviral vector in murine pre-B cells. The Embo Journal. 6: 577-584. DOI: 10.1002/J.1460-2075.1987.Tb04793.X |
0.412 |
|
| 1987 |
Reth M, Petrac E, Wiese P, Lobel L, Alt FW. Activation of V kappa gene rearrangement in pre-B cells follows the expression of membrane-bound immunoglobulin heavy chains. The Embo Journal. 6: 3299-3305. DOI: 10.1002/J.1460-2075.1987.Tb02649.X |
0.413 |
|
| 1986 |
Depinho RA, Hatton K, Ferrier P, Zimmerman K, Legouy E, Tesfaye A, Collum R, Yancopoulos G, Nisen P, Alt F. Myc family genes: a dispersed multi-gene family. Annals of Clinical Research. 18: 284-9. PMID 3551773 |
0.521 |
|
| 1986 |
Berman JE, Malynn BA, Blackwell TK, Alt FW. Regulation fo immunoglobulin variable region gene assembly: development of the primary antibody repertoire. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 5: 197-203. PMID 3545193 DOI: 10.1002/Bies.950050503 |
0.376 |
|
| 1986 |
DePinho RA, Legouy E, Feldman LB, Kohl NE, Yancopoulos GD, Alt FW. Structure and expression of the murine N-myc gene. Proceedings of the National Academy of Sciences of the United States of America. 83: 1827-31. PMID 3513190 DOI: 10.1002/J.1460-2075.1987.Tb02657.X |
0.629 |
|
| 1986 |
Kohl NE, Legouy E, DePinho RA, Nisen PD, Smith RK, Gee CE, Alt FW. Human N-myc is closely related in organization and nucleotide sequence to c-myc. Nature. 319: 73-7. PMID 3510398 DOI: 10.1038/319073A0 |
0.506 |
|
| 1986 |
Blackwell TK, Moore MW, Yancopoulos GD, Suh H, Lutzker S, Selsing E, Alt FW. Recombination between immunoglobulin variable region gene segments is enhanced by transcription. Nature. 324: 585-9. PMID 3491327 DOI: 10.1038/324585A0 |
0.569 |
|
| 1986 |
Bank I, DePinho RA, Brenner MB, Cassimeris J, Alt FW, Chess L. A functional T3 molecule associated with a novel heterodimer on the surface of immature human thymocytes. Nature. 322: 179-81. PMID 3487737 DOI: 10.1038/322179A0 |
0.499 |
|
| 1986 |
Yancopoulos GD, Blackwell TK, Suh H, Hood L, Alt FW. Introduced T cell receptor variable region gene segments recombine in pre-B cells: evidence that B and T cells use a common recombinase. Cell. 44: 251-9. PMID 3484682 DOI: 10.1016/0092-8674(86)90759-2 |
0.586 |
|
| 1986 |
Manheimer-Lory AJ, Monestier M, Bellon B, Alt FW, Bona CA. Fine specificity, idiotypy, and nature of cloned heavy-chain variable region genes of murine monoclonal rheumatoid factor antibodies Proceedings of the National Academy of Sciences of the United States of America. 83: 8293-8297. PMID 3095832 DOI: 10.1073/Pnas.83.21.8293 |
0.318 |
|
| 1986 |
Mensink EJ, Schuurman RK, Schot JD, Thompson A, Alt FW. Immunoglobulin heavy chain gene rearrangements in X-linked agammaglobulinemia. European Journal of Immunology. 16: 963-7. PMID 3091379 DOI: 10.1002/Eji.1830160815 |
0.449 |
|
| 1986 |
Yancopoulos GD, Alt FW. Regulation of the assembly and expression of variable-region genes. Annual Review of Immunology. 4: 339-68. PMID 3085692 DOI: 10.1146/Annurev.Iy.04.040186.002011 |
0.564 |
|
| 1986 |
Alt FW, Reth MG, Blackwell TK, Yancopoulos GD. Regulation of immunoglobulin variable-region gene assembly. The Mount Sinai Journal of Medicine, New York. 53: 166-9. PMID 3084957 |
0.433 |
|
| 1986 |
Alt FW, Blackwell TK, DePinho RA, Reth MG, Yancopoulos GD. Regulation of genome rearrangement events during lymphocyte differentiation. Immunological Reviews. 89: 5-30. PMID 3081433 |
0.65 |
|
| 1986 |
Alt FW, DePinho R, Zimmerman K, Legouy E, Hatton K, Ferrier P, Tesfaye A, Yancopoulos G, Nisen P. The human myc gene family. Cold Spring Harbor Symposia On Quantitative Biology. 51: 931-41. PMID 3034500 DOI: 10.1101/Sqb.1986.051.01.106 |
0.573 |
|
| 1986 |
Yancopoulos GD, DePinho RA, Zimmerman KA, Lutzker SG, Rosenberg N, Alt FW. Secondary genomic rearrangement events in pre-B cells: VHDJH replacement by a LINE-1 sequence and directed class switching. The Embo Journal. 5: 3259-66. PMID 3028778 DOI: 10.1002/J.1460-2075.1986.Tb04637.X |
0.677 |
|
| 1986 |
Reth M, Jackson S, Alt F. VHDJH formation and DJH replacement during pre-B differentiation: non-random usage of gene segments. The Embo Journal. 5: 2131-2138. DOI: 10.1002/J.1460-2075.1986.Tb04476.X |
0.417 |
|
| 1985 |
Reth MG, Alt FW. Novel immunoglobulin heavy chains are produced from DJH gene segment rearrangements in lymphoid cells. Nature. 312: 418-23. PMID 6095102 DOI: 10.1038/312418A0 |
0.367 |
|
| 1985 |
Reth MG, Ammirati P, Jackson S, Alt FW. Regulated progression of a cultured pre-B-cell line to the B-cell stage. Nature. 317: 353-5. PMID 3930970 DOI: 10.1038/317353A0 |
0.452 |
|
| 1985 |
Yancopoulos GD, Nisen PD, Tesfaye A, Kohl NE, Goldfarb MP, Alt FW. N-myc can cooperate with ras to transform normal cells in culture. Proceedings of the National Academy of Sciences of the United States of America. 82: 5455-9. PMID 3860871 DOI: 10.1073/Pnas.82.16.5455 |
0.486 |
|
| 1985 |
Yancopoulos GD, Alt FW. Developmentally controlled and tissue-specific expression of unrearranged VH gene segments. Cell. 40: 271-81. PMID 2578321 DOI: 10.1016/0092-8674(85)90141-2 |
0.552 |
|
| 1985 |
Alt FW, Keith Blackwell T, Yancopoulos GD. Immunoglobulin genes in transgenic mice Trends in Genetics. 1: 231-236. DOI: 10.1016/0168-9525(85)90089-7 |
0.526 |
|
| 1984 |
Kohl NE, Gee CE, Alt FW. Activated expression of the N-myc gene in human neuroblastomas and related tumors. Science (New York, N.Y.). 226: 1335-7. PMID 6505694 DOI: 10.1126/Science.6505694 |
0.312 |
|
| 1984 |
Blackwell TK, Alt FW. Site-specific recombination between immunoglobulin D and JH segments that were introduced into the genome of a murine pre-B cell line. Cell. 37: 105-12. PMID 6327046 DOI: 10.1016/0092-8674(84)90305-2 |
0.412 |
|
| 1984 |
DePinho R, Kruger K, Andrews N, Lutzker S, Baltimore D, Alt FW. Molecular basis of heavy-chain class switching and switch region deletion in an Abelson virus-transformed cell line. Molecular and Cellular Biology. 4: 2905-10. PMID 6098827 DOI: 10.1128/Mcb.4.12.2905 |
0.712 |
|
| 1984 |
Desiderio SV, Yancopoulos GD, Paskind M, Thomas E, Boss MA, Landau N, Alt FW, Baltimore D. Insertion of N regions into heavy-chain genes is correlated with expression of terminal deoxytransferase in B cells. Nature. 311: 752-5. PMID 6092963 DOI: 10.1038/311752A0 |
0.797 |
|
| 1984 |
Yancopoulos GD, Desiderio SV, Paskind M, Kearney JF, Baltimore D, Alt FW. Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines. Nature. 311: 727-33. PMID 6092962 DOI: 10.1038/311727A0 |
0.792 |
|
| 1984 |
Alt FW, Yancopoulos GD, Blackwell TK, Wood C, Thomas E, Boss M, Coffman R, Rosenberg N, Tonegawa S, Baltimore D. Ordered rearrangement of immunoglobulin heavy chain variable region segments. The Embo Journal. 3: 1209-19. PMID 6086308 DOI: 10.1002/J.1460-2075.1984.Tb01955.X |
0.74 |
|
| 1983 |
Kanda N, Schreck R, Alt F, Bruns G, Baltimore D, Latt S. Isolation of amplified DNA sequences from IMR-32 human neuroblastoma cells: facilitation by fluorescence-activated flow sorting of metaphase chromosomes. Proceedings of the National Academy of Sciences of the United States of America. 80: 4069-73. PMID 6575396 DOI: 10.1073/Pnas.80.13.4069 |
0.63 |
|
| 1983 |
Kohl NE, Kanda N, Schreck RR, Bruns G, Latt SA, Gilbert F, Alt FW. Transposition and amplification of oncogene-related sequences in human neuroblastomas Cell. 35: 359-367. PMID 6197179 DOI: 10.1016/0092-8674(83)90169-1 |
0.373 |
|
| 1982 |
Alt FW, Rosenberg N, Enea V, Siden E, Baltimore D. Multiple immunoglobulin heavy-chain gene transcripts in Abelson murine leukemia virus-transformed lymphoid cell lines. Molecular and Cellular Biology. 2: 386-400. PMID 6810096 DOI: 10.1128/Mcb.2.4.386 |
0.595 |
|
| 1982 |
Alt FW, Rosenberg N, Casanova RJ, Thomas E, Baltimore D. Immunoglobulin heavy-chain expression and class switching in a murine leukaemia cell line. Nature. 296: 325-31. PMID 6801527 DOI: 10.1038/296325A0 |
0.642 |
|
| 1982 |
Lewis S, Rosenberg N, Alt F, Baltimore D. Continuing kappa-gene rearrangement in a cell line transformed by Abelson murine leukemia virus. Cell. 30: 807-16. PMID 6291785 DOI: 10.1016/0092-8674(82)90285-9 |
0.618 |
|
| 1982 |
Alt FW, Baltimore D. Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions. Proceedings of the National Academy of Sciences of the United States of America. 79: 4118-22. PMID 6287467 DOI: 10.1073/Pnas.79.13.4118 |
0.621 |
|
| 1981 |
Mather EL, Alt FW, Bothwell AL, Baltimore D, Koshland ME. Expression of J chain RNA in cell lines representing different stages of B lymphocyte differentiation. Cell. 23: 369-78. PMID 6781757 DOI: 10.1016/0092-8674(81)90132-X |
0.739 |
|
| 1981 |
Alt F, Rosenberg N, Lewis S, Thomas E, Baltimore D. Organization and reorganization of immunoglobulin genes in A-MULV-transformed cells: rearrangement of heavy but not light chain genes. Cell. 27: 381-90. PMID 6277505 DOI: 10.1016/0092-8674(81)90421-9 |
0.621 |
|
| 1981 |
Siden E, Alt FW, Shinefeld L, Sato V, Baltimore D. Synthesis of immunoglobulin mu chain gene products precedes synthesis of light chains during B-lymphocyte development. Proceedings of the National Academy of Sciences of the United States of America. 78: 1823-7. PMID 6112749 DOI: 10.1073/Pnas.78.3.1823 |
0.591 |
|
| 1980 |
Alt FW, Enea V, Bothwell AL, Baltimore D. Activity of multiple light chain genes in murine myeloma cells producing a single, functional light chain. Cell. 21: 1-12. PMID 6773666 DOI: 10.1016/0092-8674(80)90109-9 |
0.713 |
|
| 1980 |
Alt FW, Bothwell AL, Knapp M, Siden E, Mather E, Koshland M, Baltimore D. Synthesis of secreted and membrane-bound immunoglobulin mu heavy chains is directed by mRNAs that differ at their 3' ends. Cell. 20: 293-301. PMID 6771018 DOI: 10.1016/0092-8674(80)90615-7 |
0.703 |
|
| 1979 |
Kellems RE, Morhenn VB, Pfendt EA, Alt FW, Schimke RT. Polyoma virus and cyclic AMP-mediated control of dihydrofolate reductase mRNA abundance in methotrexate-resistant mouse fibroblasts. The Journal of Biological Chemistry. 254: 309-18. PMID 216671 |
0.486 |
|
| 1978 |
Schimke RT, Kaufman RJ, Alt FW, Kellems RF. Gene amplification and drug resistance in cultured murine cells. Science (New York, N.Y.). 202: 1051-5. PMID 715457 DOI: 10.1126/Science.715457 |
0.61 |
|
| 1978 |
Alt FW, Kellems RE, Bertino JR, Schimke RT. Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells. The Journal of Biological Chemistry. 253: 1357-70. PMID 627542 |
0.483 |
|
| 1978 |
Schimke RT, Alt FW, Kellems RE, Kaufman RJ, Bertino JR. Amplification of dihydrofolate reductase genes in methotrexate-resistant cultured mouse cells. Cold Spring Harbor Symposia On Quantitative Biology. 42: 649-57. PMID 277312 DOI: 10.1101/Sqb.1978.042.01.067 |
0.636 |
|
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