Jay L. Zweier - Publications

Affiliations: 
Integrated Biomedical Sciences Ohio State University, Columbus, Columbus, OH 
Area:
Biochemistry, Pathology, Molecular Biology

306 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 El-Mahdy MA, Abdelghany TM, Hemann C, Ewees MG, Mahgoup EM, Eid MS, Shalaan MT, Alzarie YA, Zweier JL. Chronic Cigarette Smoke Exposure Triggers a Vicious Cycle of Leukocyte and Endothelial-Mediated Oxidant Stress that Results in Vascular Dysfunction. American Journal of Physiology. Heart and Circulatory Physiology. PMID 32412791 DOI: 10.1152/Ajpheart.00657.2019  0.313
2020 Zweier JL, Ilangovan G. Regulation of Nitric Oxide Metabolism and Vascular Tone by Cytoglobin. Antioxidants & Redox Signaling. PMID 31880165 DOI: 10.1089/Ars.2019.7881  0.351
2020 Ismail R, El-Sayed E, Mansour A, Hemann C, El-Mahdy M, Zweier J. Thymoquinone protects against cigarette smoke extract-induced vascular dysfunction through inhibition of the RhoA/Rho-kinase signaling pathway (849.1) The Faseb Journal. 28: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.08873  0.304
2019 Tan X, Ji K, Wang X, Yao R, Han G, Villamena F, Zweier J, Song Y, Rockenbauer A, Liu Y. Discriminative Detection of Biothiols through Thiol-Trapping Technique using Methanethiosulfonate Trityl Probe and Electron Paramagnetic Resonance Spectroscopy. Angewandte Chemie (International Ed. in English). PMID 31657108 DOI: 10.1002/Ange.201912832  0.321
2019 Headley CA, Hoffman CN, Freisen JM, Han Y, Macklin JM, Zweier JL, Rockenbauer A, Kuret J, Villamena FA. Membrane-specific spin trap, 5-dodecylcarbamoyl-5-N-dodecylacetamide-1-pyroline-N-oxide (diCPO): theoretical, bioorthogonal fluorescence imaging and EPR studies. Organic & Biomolecular Chemistry. PMID 31328213 DOI: 10.1039/C9Ob01334B  0.331
2019 Boslett J, Reddy N, Alzarie YA, Zweier JL. Inhibition of CD38 with the thiazoloquin(az)olin(on)e 78c protects the heart against post-ischemic injury. The Journal of Pharmacology and Experimental Therapeutics. PMID 30635470 DOI: 10.1124/Jpet.118.254557  0.323
2018 Kang PT, Chen CL, Lin P, Zhang L, Zweier JL, Chen YR. Mitochondrial complex I in the post-ischemic heart reperfusion-mediated oxidative injury and protein cysteine sulfonation. Journal of Molecular and Cellular Cardiology. PMID 30031815 DOI: 10.1016/J.Yjmcc.2018.07.244  0.3
2018 Abdelghany TM, Ismail RS, Mansoor FA, Zweier JR, Lowe F, Zweier JL. Cigarette smoke constituents cause endothelial nitric oxide synthase dysfunction and uncoupling due to depletion of tetrahydrobiopterin with degradation of GTP cyclohydrolase. Nitric Oxide : Biology and Chemistry. PMID 29524646 DOI: 10.1016/J.Niox.2018.02.009  0.335
2018 Tan X, Tao S, Liu W, Rockenbauer A, Villamena FA, Zweier JL, Song Y, Liu Y. Synthesis and Characterization of Perthiatriarylmethyl Radical and Its Dendritic Derivatives with High Sensitivity and Selectivity to Superoxide Radical. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 29505165 DOI: 10.1002/Chem.201800134  0.328
2018 Boslett J, Helal M, Chini E, Zweier JL. Genetic deletion of CD38 confers post-ischemic myocardial protection through preserved pyridine nucleotides. Journal of Molecular and Cellular Cardiology. PMID 29476764 DOI: 10.1016/J.Yjmcc.2018.02.015  0.335
2017 Varadharaj S, Kelly OJ, Khayat RN, Kumar PS, Ahmed N, Zweier JL. Role of Dietary Antioxidants in the Preservation of Vascular Function and the Modulation of Health and Disease. Frontiers in Cardiovascular Medicine. 4: 64. PMID 29164133 DOI: 10.3389/Fcvm.2017.00064  0.367
2017 Tan X, Chen L, Song Y, Rockenbauer A, Villamena FA, Zweier JL, Liu Y. Thiol-dependent reduction of the triester and triamide derivatives of Finland trityl radical triggers O2-dependent superoxide production. Chemical Research in Toxicology. PMID 28759716 DOI: 10.1021/Acs.Chemrestox.7B00086  0.363
2017 Zhou D, Hemann C, Boslett J, Luo A, Zweier JL, Liu X. Oxygen binding and nitric oxide dioxygenase activity of cytoglobin are altered to different extents by cysteine modification. Febs Open Bio. 7: 845-853. PMID 28593139 DOI: 10.1002/2211-5463.12230  0.332
2017 Liu X, El-Mahdy MA, Boslett J, Varadharaj S, Hemann C, Abdelghany TM, Ismail RS, Little SC, Zhou D, Thuy LT, Kawada N, Zweier JL. Cytoglobin regulates blood pressure and vascular tone through nitric oxide metabolism in the vascular wall. Nature Communications. 8: 14807. PMID 28393874 DOI: 10.1038/Ncomms14807  0.327
2017 Zhang B, Novitskaya T, Wheeler DG, Xu Z, Chepurko E, Huttinger R, He H, Varadharaj S, Zweier JL, Song Y, Xu M, Harrell FE, Su YR, Absi T, Kohr MJ, et al. Kcnj11 Ablation Is Associated With Increased Nitro-Oxidative Stress During Ischemia-Reperfusion Injury: Implications for Human Ischemic Cardiomyopathy. Circulation. Heart Failure. 10. PMID 28209764 DOI: 10.1161/Circheartfailure.116.003523  0.336
2017 Boslett J, Hemann C, Zhao YJ, Lee HC, Zweier JL. Luteolinidin protects the post-ischemic heart through CD38 inhibition with preservation of NAD(P)(H). The Journal of Pharmacology and Experimental Therapeutics. PMID 28108596 DOI: 10.1124/Jpet.116.239459  0.353
2016 Liu W, Nie J, Tan X, Liu H, Yu N, Han G, Zhu Y, Villamena FA, Song Y, Zweier JL, Liu Y. Synthesis and Characterization of PEGylated Trityl Radicals: Effect of PEGylation on Physicochemical Properties. The Journal of Organic Chemistry. PMID 28005365 DOI: 10.1021/Acs.Joc.6B02590  0.353
2016 Dhimitruka I, Alzarie YA, Hemann C, Samouilov A, Zweier JL. Trityl radicals in perfluorocarbon emulsions as stable, sensitive, and biocompatible oximetry probes. Bioorganic & Medicinal Chemistry Letters. PMID 27836400 DOI: 10.1016/J.Bmcl.2016.10.066  0.353
2016 Griendling KK, Touyz RM, Zweier JL, Dikalov S, Chilian W, Chen YR, Harrison DG, Bhatnagar A. Measurement of Reactive Oxygen Species, Reactive Nitrogen Species, and Redox-Dependent Signaling in the Cardiovascular System: A Scientific Statement From the American Heart Association. Circulation Research. PMID 27418630 DOI: 10.1161/Res.0000000000000110  0.326
2016 Velayutham M, Hemann CF, Cardounel AJ, Zweier JL. Sulfite Oxidase Activity of Cytochrome c: Role of Hydrogen Peroxide. Biochemistry and Biophysics Reports. 5: 96-104. PMID 26709389 DOI: 10.1016/J.Bbrep.2015.11.025  0.351
2015 Reyes LA, Boslett J, Varadharaj S, De Pascali F, Hemann C, Druhan LJ, Ambrosio G, El-Mahdy M, Zweier JL. Depletion of NADP(H) due to CD38 activation triggers endothelial dysfunction in the postischemic heart. Proceedings of the National Academy of Sciences of the United States of America. 112: 11648-53. PMID 26297248 DOI: 10.1073/Pnas.1505556112  0.768
2015 Conklin DJ, Guo Y, Jagatheesan G, Kilfoil PJ, Haberzettl P, Hill BG, Baba SP, Guo L, Wetzelberger K, Obal D, Rokosh DG, Prough RA, Prabhu SD, Velayutham M, Zweier JL, et al. Genetic Deficiency of Glutathione S-Transferase P Increases Myocardial Sensitivity to Ischemia-Reperfusion Injury. Circulation Research. 117: 437-49. PMID 26169370 DOI: 10.1161/Circresaha.114.305518  0.336
2015 Xie L, Talukder MA, Sun J, Varadharaj S, Zweier JL. Liposomal tetrahydrobiopterin preserves eNOS coupling in the post-ischemic heart conferring in vivo cardioprotection. Journal of Molecular and Cellular Cardiology. PMID 26116866 DOI: 10.1016/J.Yjmcc.2015.06.015  0.391
2015 Varadharaj S, Porter K, Pleister A, Wannemacher J, Sow A, Jarjoura D, Zweier JL, Khayat RN. Endothelial nitric oxide synthase uncoupling: a novel pathway in OSA induced vascular endothelial dysfunction. Respiratory Physiology & Neurobiology. 207: 40-7. PMID 25534145 DOI: 10.1016/J.Resp.2014.12.012  0.316
2015 Silbajoris R, Linak W, Shenderova O, Winterrowd C, Chang HC, Zweier JL, Kota A, Dailey LA, Nunn N, Bromberg PA, Samet JM. Detonation nanodiamond toxicity in human airway epithelial cells is modulated by air oxidation Diamond and Related Materials. 58: 16-23. DOI: 10.1016/J.Diamond.2015.05.007  0.334
2014 Scheitlin CG, Nair DM, Crestanello JA, Zweier JL, Alevriadou BR. Fluid Mechanical Forces and Endothelial Mitochondria: A Bioengineering Perspective. Cellular and Molecular Bioengineering. 7: 483-496. PMID 25530817 DOI: 10.1007/S12195-014-0357-4  0.338
2014 Lee MC, Velayutham M, Komatsu T, Hille R, Zweier JL. Measurement and characterization of superoxide generation from xanthine dehydrogenase: a redox-regulated pathway of radical generation in ischemic tissues. Biochemistry. 53: 6615-23. PMID 25243829 DOI: 10.1021/Bi500582R  0.404
2014 Quarrie R, Lee DS, Reyes L, Erdahl W, Pfeiffer DR, Zweier JL, Crestanello JA. Mitochondrial uncoupling does not decrease reactive oxygen species production after ischemia-reperfusion. American Journal of Physiology. Heart and Circulatory Physiology. 307: H996-H1004. PMID 25085966 DOI: 10.1152/Ajpheart.00189.2014  0.766
2014 De Pascali F, Hemann C, Samons K, Chen CA, Zweier JL. Hypoxia and reoxygenation induce endothelial nitric oxide synthase uncoupling in endothelial cells through tetrahydrobiopterin depletion and S-glutathionylation. Biochemistry. 53: 3679-88. PMID 24758136 DOI: 10.1021/Bi500076R  0.38
2014 Bobko AA, Dhimitruka I, Zweier JL, Khramtsov VV. Fourier transform EPR spectroscopy of trityl radicals for multifunctional assessment of chemical microenvironment. Angewandte Chemie (International Ed. in English). 53: 2735-8. PMID 24488710 DOI: 10.1002/Anie.201310841  0.33
2014 Chen YR, Zweier JL. Cardiac mitochondria and reactive oxygen species generation. Circulation Research. 114: 524-37. PMID 24481843 DOI: 10.1161/Circresaha.114.300559  0.379
2014 Moldovan NI, Anghelina M, Varadharaj S, Butt OI, Wang T, Yang F, Moldovan L, Zweier JL. Reoxygenation-derived toxic reactive oxygen/nitrogen species modulate the contribution of bone marrow progenitor cells to remodeling after myocardial infarction. Journal of the American Heart Association. 3: e000471. PMID 24419735 DOI: 10.1161/Jaha.113.000471  0.317
2014 Das A, Gopalakrishnan B, Druhan LJ, Wang TY, De Pascali F, Rockenbauer A, Racoma I, Varadharaj S, Zweier JL, Cardounel AJ, Villamena FA. Reversal of SIN-1-induced eNOS dysfunction by the spin trap, DMPO, in bovine aortic endothelial cells via eNOS phosphorylation. British Journal of Pharmacology. 171: 2321-34. PMID 24405159 DOI: 10.1111/Bph.12572  0.389
2013 Chen CA, De Pascali F, Basye A, Hemann C, Zweier JL. Redox modulation of endothelial nitric oxide synthase by glutaredoxin-1 through reversible oxidative post-translational modification. Biochemistry. 52: 6712-23. PMID 23977830 DOI: 10.1021/Bi400404S  0.37
2013 Liu X, Tong J, Zweier JR, Follmer D, Hemann C, Ismail RS, Zweier JL. Differences in oxygen-dependent nitric oxide metabolism by cytoglobin and myoglobin account for their differing functional roles. The Febs Journal. 280: 3621-31. PMID 23710929 DOI: 10.1111/Febs.12352  0.368
2013 Song Y, Liu Y, Hemann C, Villamena FA, Zweier JL. Esterified dendritic TAM radicals with very high stability and enhanced oxygen sensitivity. The Journal of Organic Chemistry. 78: 1371-6. PMID 23343531 DOI: 10.1021/Jo301849K  0.324
2013 Talukder MA, Elnakish MT, Yang F, Nishijima Y, Alhaj MA, Velayutham M, Hassanain HH, Zweier JL. Cardiomyocyte-specific overexpression of an active form of Rac predisposes the heart to increased myocardial stunning and ischemia-reperfusion injury. American Journal of Physiology. Heart and Circulatory Physiology. 304: H294-302. PMID 23161879 DOI: 10.1152/Ajpheart.00367.2012  0.353
2013 Chen Z, Reyes LA, Johnson DH, Velayutham M, Yang C, Samouilov A, Zweier JL. Fast gated EPR imaging of the beating heart: spatiotemporally resolved 3D imaging of free-radical distribution during the cardiac cycle. Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 69: 594-601. PMID 22473660 DOI: 10.1002/Mrm.24250  0.763
2013 Velayutham M, Zweier JL. Nitric Oxide Signaling in Biology Messenger. 2: 1-18. DOI: 10.1166/Msr.2013.1018  0.312
2012 Kohr MJ, Roof SR, Zweier JL, Ziolo MT. Modulation of myocardial contraction by peroxynitrite. Frontiers in Physiology. 3: 468. PMID 23248603 DOI: 10.3389/Fphys.2012.00468  0.316
2012 Obal D, Dai S, Keith R, Dimova N, Kingery J, Zheng YT, Zweier J, Velayutham M, Prabhu SD, Li Q, Conklin D, Yang D, Bhatnagar A, Bolli R, Rokosh G. Cardiomyocyte-restricted overexpression of extracellular superoxide dismutase increases nitric oxide bioavailability and reduces infarct size after ischemia/reperfusion. Basic Research in Cardiology. 107: 305. PMID 23099819 DOI: 10.1007/S00395-012-0305-1  0.414
2012 Li H, Hemann C, Abdelghany TM, El-Mahdy MA, Zweier JL. Characterization of the mechanism and magnitude of cytoglobin-mediated nitrite reduction and nitric oxide generation under anaerobic conditions. The Journal of Biological Chemistry. 287: 36623-33. PMID 22896706 DOI: 10.1074/Jbc.M112.342378  0.392
2012 Quarrie R, Lee DS, Steinbaugh G, Cramer B, Erdahl W, Pfeiffer DR, Zweier JL, Crestanello JA. Ischemic preconditioning preserves mitochondrial membrane potential and limits reactive oxygen species production. The Journal of Surgical Research. 178: 8-17. PMID 22763215 DOI: 10.1016/J.Jss.2012.05.090  0.322
2012 Liu X, Follmer D, Zweier JR, Huang X, Hemann C, Liu K, Druhan LJ, Zweier JL. Characterization of the function of cytoglobin as an oxygen-dependent regulator of nitric oxide concentration. Biochemistry. 51: 5072-82. PMID 22577939 DOI: 10.1021/Bi300291H  0.326
2012 Kundu TK, Velayutham M, Zweier JL. Aldehyde oxidase functions as a superoxide generating NADH oxidase: an important redox regulated pathway of cellular oxygen radical formation. Biochemistry. 51: 2930-9. PMID 22404107 DOI: 10.1021/Bi3000879  0.388
2012 Caia GL, Efimova OV, Velayutham M, El-Mahdy MA, Abdelghany TM, Kesselring E, Petryakov S, Sun Z, Samouilov A, Zweier JL. Organ specific mapping of in vivo redox state in control and cigarette smoke-exposed mice using EPR/NMR co-imaging. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 216: 21-7. PMID 22296801 DOI: 10.1016/J.Jmr.2011.10.017  0.31
2012 Biondi R, Ambrosio G, De Pascali F, Tritto I, Capodicasa E, Druhan LJ, Hemann C, Zweier JL. HPLC analysis of tetrahydrobiopterin and its pteridine derivatives using sequential electrochemical and fluorimetric detection: application to tetrahydrobiopterin autoxidation and chemical oxidation. Archives of Biochemistry and Biophysics. 520: 7-16. PMID 22286026 DOI: 10.1016/J.Abb.2012.01.010  0.395
2012 Lee HL, Chen CL, Yeh ST, Zweier JL, Chen YR. Biphasic modulation of the mitochondrial electron transport chain in myocardial ischemia and reperfusion. American Journal of Physiology. Heart and Circulatory Physiology. 302: H1410-22. PMID 22268109 DOI: 10.1152/Ajpheart.00731.2011  0.359
2012 Komarov DA, Dhimitruka I, Kirilyuk IA, Trofimiov DG, Grigor'ev IA, Zweier JL, Khramtsov VV. Electron paramagnetic resonance monitoring of ischemia-induced myocardial oxygen depletion and acidosis in isolated rat hearts using soluble paramagnetic probes. Magnetic Resonance in Medicine. 68: 649-55. PMID 22162021 DOI: 10.1002/Mrm.23251  0.363
2012 Giedt RJ, Yang C, Zweier JL, Matzavinos A, Alevriadou BR. Mitochondrial fission in endothelial cells after simulated ischemia/reperfusion: role of nitric oxide and reactive oxygen species. Free Radical Biology & Medicine. 52: 348-56. PMID 22100972 DOI: 10.1016/J.Freeradbiomed.2011.10.491  0.356
2011 Cai M, Huttinger ZM, He H, Zhang W, Li F, Goodman LA, Wheeler DG, Druhan LJ, Zweier JL, Dwyer KM, He G, d'Apice AJ, Robson SC, Cowan PJ, Gumina RJ. Transgenic over expression of ectonucleotide triphosphate diphosphohydrolase-1 protects against murine myocardial ischemic injury. Journal of Molecular and Cellular Cardiology. 51: 927-35. PMID 21939667 DOI: 10.1016/J.Yjmcc.2011.09.003  0.321
2011 Zweier JL, Chen CA, Talukder MA. Cardiac resynchronization therapy and reverse molecular remodeling: importance of mitochondrial redox signaling. Circulation Research. 109: 716-9. PMID 21921269 DOI: 10.1161/Circresaha.111.253864  0.318
2011 Efimova OV, Caia GL, Sun Z, Petryakov S, Kesselring E, Samouilov A, Zweier JL. Standard-based method for proton-electron double resonance imaging of oxygen. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 212: 197-203. PMID 21807539 DOI: 10.1016/J.Jmr.2011.06.030  0.341
2011 Karuppiah K, Druhan LJ, Chen CA, Smith T, Zweier JL, Sessa WC, Cardounel AJ. Suppression of eNOS-derived superoxide by caveolin-1: a biopterin-dependent mechanism. American Journal of Physiology. Heart and Circulatory Physiology. 301: H903-11. PMID 21724868 DOI: 10.1152/Ajpheart.00936.2010  0.385
2011 Chen CA, Lin CH, Druhan LJ, Wang TY, Chen YR, Zweier JL. Superoxide induces endothelial nitric-oxide synthase protein thiyl radical formation, a novel mechanism regulating eNOS function and coupling. The Journal of Biological Chemistry. 286: 29098-107. PMID 21666221 DOI: 10.1074/Jbc.M111.240127  0.399
2011 Velayutham M, Hemann C, Zweier JL. Removal of H₂O₂ and generation of superoxide radical: role of cytochrome c and NADH. Free Radical Biology & Medicine. 51: 160-70. PMID 21545835 DOI: 10.1016/J.Freeradbiomed.2011.04.007  0.407
2011 Liu Y, Song Y, Rockenbauer A, Sun J, Hemann C, Villamena FA, Zweier JL. Synthesis of trityl radical-conjugated disulfide biradicals for measurement of thiol concentration. The Journal of Organic Chemistry. 76: 3853-60. PMID 21488696 DOI: 10.1021/Jo200265U  0.355
2011 Nishijima Y, Sridhar A, Bonilla I, Velayutham M, Khan M, Terentyeva R, Li C, Kuppusamy P, Elton TS, Terentyev D, Györke S, Zweier JL, Cardounel AJ, Carnes CA. Tetrahydrobiopterin depletion and NOS2 uncoupling contribute to heart failure-induced alterations in atrial electrophysiology. Cardiovascular Research. 91: 71-9. PMID 21460065 DOI: 10.1093/Cvr/Cvr087  0.309
2011 Chen J, Chen CL, Alevriadou BR, Zweier JL, Chen YR. Excess no predisposes mitochondrial succinate-cytochrome c reductase to produce hydroxyl radical. Biochimica Et Biophysica Acta. 1807: 491-502. PMID 21406178 DOI: 10.1016/J.Bbabio.2011.03.001  0.431
2011 Mital R, Zhang W, Cai M, Huttinger ZM, Goodman LA, Wheeler DG, Ziolo MT, Dwyer KM, d'Apice AJ, Zweier JL, He G, Cowan PJ, Gumina RJ. Antioxidant network expression abrogates oxidative posttranslational modifications in mice. American Journal of Physiology. Heart and Circulatory Physiology. 300: H1960-70. PMID 21335461 DOI: 10.1152/Ajpheart.01285.2010  0.374
2011 Muir WW, Ilangovan G, Zweier JL, Moon-Massat PF, Rentko VT. Vital organ tissue oxygenation after serial normovolemic exchange transfusion with HBOC-201 in anesthetized swine. Shock (Augusta, Ga.). 35: 597-603. PMID 21330945 DOI: 10.1097/Shk.0B013E31821366F6  0.321
2011 Zweier JL, Chen CA, Druhan LJ. S-glutathionylation reshapes our understanding of endothelial nitric oxide synthase uncoupling and nitric oxide/reactive oxygen species-mediated signaling. Antioxidants & Redox Signaling. 14: 1769-75. PMID 21261471 DOI: 10.1089/Ars.2011.3904  0.405
2011 Joddar B, Reen RK, Firstenberg MS, Varadharaj S, McCord JM, Zweier JL, Gooch KJ. Protandim attenuates intimal hyperplasia in human saphenous veins cultured ex vivo via a catalase-dependent pathway. Free Radical Biology & Medicine. 50: 700-9. PMID 21167278 DOI: 10.1016/J.Freeradbiomed.2010.12.008  0.341
2011 Talukder MA, Yang F, Nishijima Y, Chen CA, Xie L, Mahamud SD, Kalyanasundaram A, Bonagura JD, Periasamy M, Zweier JL. Detrimental effects of thyroid hormone analog DITPA in the mouse heart: increased mortality with in vivo acute myocardial ischemia-reperfusion. American Journal of Physiology. Heart and Circulatory Physiology. 300: H702-11. PMID 21131480 DOI: 10.1152/Ajpheart.00514.2010  0.316
2011 Quarrie R, Cramer BM, Lee DS, Steinbaugh GE, Erdahl W, Pfeiffer DR, Zweier JL, Crestanello JA. Ischemic preconditioning decreases mitochondrial proton leak and reactive oxygen species production in the postischemic heart. The Journal of Surgical Research. 165: 5-14. PMID 21035133 DOI: 10.1016/J.Jss.2010.09.018  0.329
2011 Nishijima Y, Sridhar A, Zweier JL, Cardounel AJ, Carnes CA. Is NOS uncoupling the missing link between atrial fibrillation and chronic non-ischaemic cardiomyopathy? Reply Cardiovascular Research. 91: 557-558. DOI: 10.1093/Cvr/Cvr178  0.303
2011 Zweier JL, Yang F, Yang C, Varadharaj S, Chen C, Talukder MH. POSTCONDITIONING PROTECTS THE HEART AGAINST IN VIVO ISCHEMIA REPERFUSION INJURY WITH REDUCED INFARCTION AND DECREASED SUPEROXIDE GENERATION: COMPARISON WITH EARLY ISCHEMIC PRECONDITIONING IN RATS Journal of the American College of Cardiology. 57: E970. DOI: 10.1016/S0735-1097(11)60970-4  0.325
2011 Quarrie R, Lee D, Erdahl W, Pfeiffer D, Zweier J, Crestanello J. Increased Mitochondrial Sensitivity To Proton Leak Is Responsible For Decreased Reactive Oxygen Species Production In Ischemic Preconditioning Journal of Surgical Research. 165: 262-263. DOI: 10.1016/J.Jss.2010.11.443  0.324
2010 Chen CA, Wang TY, Varadharaj S, Reyes LA, Hemann C, Talukder MA, Chen YR, Druhan LJ, Zweier JL. S-glutathionylation uncouples eNOS and regulates its cellular and vascular function. Nature. 468: 1115-8. PMID 21179168 DOI: 10.1038/Nature09599  0.777
2010 Kim SU, Liu Y, Nash KM, Zweier JL, Rockenbauer A, Villamena FA. Fast reactivity of a cyclic nitrone-calix[4]pyrrole conjugate with superoxide radical anion: theoretical and experimental studies. Journal of the American Chemical Society. 132: 17157-73. PMID 21070040 DOI: 10.1021/Ja105198C  0.367
2010 Liu Y, Villamena FA, Song Y, Sun J, Rockenbauer A, Zweier JL. Synthesis of 14N- and 15N-labeled trityl-nitroxide biradicals with strong spin-spin interaction and improved sensitivity to redox status and oxygen. The Journal of Organic Chemistry. 75: 7796-802. PMID 21028905 DOI: 10.1021/Jo1016844  0.341
2010 Ahmad R, Caia G, Potter LC, Petryakov S, Kuppusamy P, Zweier JL. In vivo multisite oximetry using EPR-NMR coimaging. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 207: 69-77. PMID 20850361 DOI: 10.1016/J.Jmr.2010.08.011  0.303
2010 Dhimitruka I, Grigorieva O, Zweier JL, Khramtsov VV. Synthesis, structure, and EPR characterization of deuterated derivatives of Finland trityl radical. Bioorganic & Medicinal Chemistry Letters. 20: 3946-9. PMID 20537895 DOI: 10.1016/J.Bmcl.2010.05.006  0.355
2010 Talukder MA, Yang F, Shimokawa H, Zweier JL. eNOS is required for acute in vivo ischemic preconditioning of the heart: effects of ischemic duration and sex. American Journal of Physiology. Heart and Circulatory Physiology. 299: H437-45. PMID 20525875 DOI: 10.1152/Ajpheart.00384.2010  0.348
2010 Vedam K, Nishijima Y, Druhan LJ, Khan M, Moldovan NI, Zweier JL, Ilangovan G. Role of heat shock factor-1 activation in the doxorubicin-induced heart failure in mice. American Journal of Physiology. Heart and Circulatory Physiology. 298: H1832-41. PMID 20363884 DOI: 10.1152/Ajpheart.01047.2009  0.303
2010 Chen W, Druhan LJ, Chen CA, Hemann C, Chen YR, Berka V, Tsai AL, Zweier JL. Peroxynitrite induces destruction of the tetrahydrobiopterin and heme in endothelial nitric oxide synthase: transition from reversible to irreversible enzyme inhibition. Biochemistry. 49: 3129-37. PMID 20184376 DOI: 10.1021/Bi9016632  0.367
2010 Liu Y, Villamena FA, Rockenbauer A, Zweier JL. Trityl-nitroxide biradicals as unique molecular probes for the simultaneous measurement of redox status and oxygenation. Chemical Communications (Cambridge, England). 46: 628-30. PMID 20062884 DOI: 10.1039/B919279D  0.334
2010 Zweier JL, Li H, Samouilov A, Liu X. Mechanisms of nitrite reduction to nitric oxide in the heart and vessel wall. Nitric Oxide : Biology and Chemistry / Official Journal of the Nitric Oxide Society. 22: 83-90. PMID 20044016 DOI: 10.1016/J.Niox.2009.12.004  0.42
2010 Liu X, Srinivasan P, Collard E, Grajdeanu P, Lok K, Boyle SE, Friedman A, Zweier JL. Oxygen regulates the effective diffusion distance of nitric oxide in the aortic wall. Free Radical Biology & Medicine. 48: 554-9. PMID 19969071 DOI: 10.1016/J.Freeradbiomed.2009.11.024  0.346
2010 Chen J, Chen CL, Rawale S, Chen CA, Zweier JL, Kaumaya PT, Chen YR. Peptide-based antibodies against glutathione-binding domains suppress superoxide production mediated by mitochondrial complex I. The Journal of Biological Chemistry. 285: 3168-80. PMID 19940158 DOI: 10.1074/Jbc.M109.056846  0.307
2010 Sun J, Druhan LJ, Zweier JL. Reactive oxygen and nitrogen species regulate inducible nitric oxide synthase function shifting the balance of nitric oxide and superoxide production. Archives of Biochemistry and Biophysics. 494: 130-7. PMID 19932078 DOI: 10.1016/J.Abb.2009.11.019  0.412
2010 Lee D, Steinbaugh G, Quarrie R, Cramer B, Pfeiffer D, Zweier J, Crestanello J. Ischemic Preconditioning Preserves Respiratory Complex Activity and Decreases Reactive Oxygen Species Production in Rat Heart Mitochondria Journal of Surgical Research. 158: 357. DOI: 10.1016/J.Jss.2009.11.511  0.341
2010 Cramer B, Quarrie R, Lee D, Steinbaugh G, Erdahl W, Pfeiffer D, Zweier J, Crestanello J. Ischemic Preconditioning Attenuates Mitochondrial H+ Leak and Decreases Reactive Oxygen Species Production Journal of Surgical Research. 158: 307. DOI: 10.1016/J.Jss.2009.11.378  0.324
2010 Li H, Cui H, Wang T, Zweier JL. Endogenous Methyl-arginine in Regulation of Nitric Oxide Generation from Inducible Nitric Oxide synthase Free Radical Biology and Medicine. 49: S116-S117. DOI: 10.1016/J.Freeradbiomed.2010.10.316  0.338
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2009 Lundberg JO, Gladwin MT, Ahluwalia A, Benjamin N, Bryan NS, Butler A, Cabrales P, Fago A, Feelisch M, Ford PC, Freeman BA, Frenneaux M, Friedman J, Kelm M, Kevil CG, ... ... Zweier JL, et al. Nitrate and nitrite in biology, nutrition and therapeutics. Nature Chemical Biology. 5: 865-9. PMID 19915529 DOI: 10.1038/Nchembio.260  0.337
2009 Li H, Kundu TK, Zweier JL. Characterization of the magnitude and mechanism of aldehyde oxidase-mediated nitric oxide production from nitrite. The Journal of Biological Chemistry. 284: 33850-8. PMID 19801639 DOI: 10.1074/Jbc.M109.019125  0.364
2009 Holland R, Navamal M, Velayutham M, Zweier JL, Kensler TW, Fishbein JC. Hydrogen peroxide is a second messenger in phase 2 enzyme induction by cancer chemopreventive dithiolethiones. Chemical Research in Toxicology. 22: 1427-34. PMID 19785463 DOI: 10.1021/Tx900110N  0.328
2009 Woldman YY, Sun J, Zweier JL, Khramtsov VV. Direct chemiluminescence detection of nitric oxide in aqueous solutions using the natural nitric oxide target soluble guanylyl cyclase. Free Radical Biology & Medicine. 47: 1339-45. PMID 19751819 DOI: 10.1016/J.Freeradbiomed.2009.09.007  0.359
2009 Han Y, Liu Y, Rockenbauer A, Zweier JL, Durand G, Villamena FA. Lipophilic beta-cyclodextrin cyclic-nitrone conjugate: synthesis and spin trapping studies. The Journal of Organic Chemistry. 74: 5369-80. PMID 19530689 DOI: 10.1021/Jo900856X  0.302
2009 Bobko AA, Dhimitruka I, Eubank TD, Marsh CB, Zweier JL, Khramtsov VV. Trityl-based EPR probe with enhanced sensitivity to oxygen. Free Radical Biology & Medicine. 47: 654-8. PMID 19523513 DOI: 10.1016/J.Freeradbiomed.2009.06.007  0.339
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2009 van Faassen EE, Bahrami S, Feelisch M, Hogg N, Kelm M, Kim-Shapiro DB, Kozlov AV, Li H, Lundberg JO, Mason R, Nohl H, Rassaf T, Samouilov A, Slama-Schwok A, Shiva S, ... ... Zweier J, et al. Nitrite as regulator of hypoxic signaling in mammalian physiology. Medicinal Research Reviews. 29: 683-741. PMID 19219851 DOI: 10.1002/Med.20151  0.389
2009 Zuo L, Chen YR, Reyes LA, Lee HL, Chen CL, Villamena FA, Zweier JL. The radical trap 5,5-dimethyl-1-pyrroline N-oxide exerts dose-dependent protection against myocardial ischemia-reperfusion injury through preservation of mitochondrial electron transport. The Journal of Pharmacology and Experimental Therapeutics. 329: 515-23. PMID 19201989 DOI: 10.1124/Jpet.108.143479  0.787
2009 Liu B, Tewari AK, Zhang L, Green-Church KB, Zweier JL, Chen YR, He G. Proteomic analysis of protein tyrosine nitration after ischemia reperfusion injury: mitochondria as the major target. Biochimica Et Biophysica Acta. 1794: 476-85. PMID 19150419 DOI: 10.1016/J.Bbapap.2008.12.008  0.34
2009 Liu Y, Villamena FA, Sun J, Wang TY, Zweier JL. Esterified trityl radicals as intracellular oxygen probes. Free Radical Biology & Medicine. 46: 876-83. PMID 19135524 DOI: 10.1016/J.Freeradbiomed.2008.12.011  0.369
2009 Han Z, Varadharaj S, Giedt RJ, Zweier JL, Szeto HH, Alevriadou BR. Mitochondria-derived reactive oxygen species mediate heme oxygenase-1 expression in sheared endothelial cells. The Journal of Pharmacology and Experimental Therapeutics. 329: 94-101. PMID 19131585 DOI: 10.1124/Jpet.108.145557  0.387
2009 Villamena FA, Liu Y, Zweier JL. Superoxide radical anion adduct of 5,5-dimethyl-1-pyrroline N-oxide. 4. Conformational effects on the EPR hyperfine splitting constants. The Journal of Physical Chemistry. A. 112: 12607-15. PMID 19012384 DOI: 10.1021/Jp8070579  0.34
2009 Crestanello JA, Lee DS, Steinbaugh G, Pfeiffer D, Zweier J. Superoxide radical production by mitochondrial respiratory complexes I and III is decreased by ischemic preconditioning Journal of the American College of Surgeons. 209: S33. DOI: 10.1016/J.Jamcollsurg.2009.06.069  0.31
2008 West MB, Rokosh G, Obal D, Velayutham M, Xuan YT, Hill BG, Keith RJ, Schrader J, Guo Y, Conklin DJ, Prabhu SD, Zweier JL, Bolli R, Bhatnagar A. Cardiac myocyte-specific expression of inducible nitric oxide synthase protects against ischemia/reperfusion injury by preventing mitochondrial permeability transition. Circulation. 118: 1970-8. PMID 18936326 DOI: 10.1161/Circulationaha.108.791533  0.371
2008 Tejero J, Biswas A, Wang ZQ, Page RC, Haque MM, Hemann C, Zweier JL, Misra S, Stuehr DJ. Stabilization and characterization of a heme-oxy reaction intermediate in inducible nitric-oxide synthase. The Journal of Biological Chemistry. 283: 33498-507. PMID 18815130 DOI: 10.1074/Jbc.M806122200  0.311
2008 Liu Y, Villamena FA, Zweier JL. Highly stable dendritic trityl radicals as oxygen and pH probe. Chemical Communications (Cambridge, England). 4336-8. PMID 18802562 DOI: 10.1039/B807406B  0.319
2008 Presley T, Vedam K, Velayutham M, Zweier JL, Ilangovan G. Activation of Hsp90-eNOS and increased NO generation attenuate respiration of hypoxia-treated endothelial cells. American Journal of Physiology. Cell Physiology. 295: C1281-91. PMID 18787079 DOI: 10.1152/Ajpcell.00550.2007  0.342
2008 Xu Y, Liu B, Zweier JL, He G. Formation of hydrogen peroxide and reduction of peroxynitrite via dismutation of superoxide at reperfusion enhances myocardial blood flow and oxygen consumption in postischemic mouse heart. The Journal of Pharmacology and Experimental Therapeutics. 327: 402-10. PMID 18685120 DOI: 10.1124/Jpet.108.142372  0.388
2008 Chen CL, Chen J, Rawale S, Varadharaj S, Kaumaya PP, Zweier JL, Chen YR. Protein tyrosine nitration of the flavin subunit is associated with oxidative modification of mitochondrial complex II in the post-ischemic myocardium. The Journal of Biological Chemistry. 283: 27991-8003. PMID 18682392 DOI: 10.1074/Jbc.M802691200  0.362
2008 Dhimitruka I, Bobko AA, Hadad CM, Zweier JL, Khramtsov VV. Synthesis and characterization of amino derivatives of persistent trityl radicals as dual function pH and oxygen paramagnetic probes. Journal of the American Chemical Society. 130: 10780-7. PMID 18636723 DOI: 10.1021/Ja803083Z  0.313
2008 Chen CA, Druhan LJ, Varadharaj S, Chen YR, Zweier JL. Phosphorylation of endothelial nitric-oxide synthase regulates superoxide generation from the enzyme. The Journal of Biological Chemistry. 283: 27038-47. PMID 18622039 DOI: 10.1074/Jbc.M802269200  0.328
2008 Druhan LJ, Forbes SP, Pope AJ, Chen CA, Zweier JL, Cardounel AJ. Regulation of eNOS-derived superoxide by endogenous methylarginines. Biochemistry. 47: 7256-63. PMID 18553936 DOI: 10.1021/Bi702377A  0.332
2008 Alzawahra WF, Talukder MA, Liu X, Samouilov A, Zweier JL. Heme proteins mediate the conversion of nitrite to nitric oxide in the vascular wall. American Journal of Physiology. Heart and Circulatory Physiology. 295: H499-508. PMID 18539756 DOI: 10.1152/Ajpheart.00374.2008  0.335
2008 Jones CI, Han Z, Presley T, Varadharaj S, Zweier JL, Ilangovan G, Alevriadou BR. Endothelial cell respiration is affected by the oxygen tension during shear exposure: role of mitochondrial peroxynitrite. American Journal of Physiology. Cell Physiology. 295: C180-91. PMID 18480296 DOI: 10.1152/Ajpcell.00549.2007  0.328
2008 Li H, Cui H, Kundu TK, Alzawahra W, Zweier JL. Nitric oxide production from nitrite occurs primarily in tissues not in the blood: critical role of xanthine oxidase and aldehyde oxidase. The Journal of Biological Chemistry. 283: 17855-63. PMID 18424432 DOI: 10.1074/Jbc.M801785200  0.374
2008 Han Y, Tuccio B, Lauricella R, Rockenbauer A, Zweier JL, Villamena FA. Synthesis and spin-trapping properties of a new spirolactonyl nitrone. The Journal of Organic Chemistry. 73: 2533-41. PMID 18331054 DOI: 10.1021/Jo702434U  0.326
2008 Sun J, Druhan LJ, Zweier JL. Dose dependent effects of reactive oxygen and nitrogen species on the function of neuronal nitric oxide synthase. Archives of Biochemistry and Biophysics. 471: 126-33. PMID 18201545 DOI: 10.1016/J.Abb.2008.01.003  0.392
2008 Liu Y, Villamena FA, Sun J, Xu Y, Dhimitruka I, Zweier JL. Synthesis and characterization of ester-derivatized tetrathiatriarylmethyl radicals as intracellular oxygen probes. The Journal of Organic Chemistry. 73: 1490-7. PMID 18201099 DOI: 10.1021/Jo7022747  0.387
2007 Dhimitruka I, Velayutham M, Bobko AA, Khramtsov VV, Villamena FA, Hadad CM, Zweier JL. Large-scale synthesis of a persistent trityl radical for use in biomedical EPR applications and imaging. Bioorganic & Medicinal Chemistry Letters. 17: 6801-5. PMID 17964156 DOI: 10.1016/J.Bmcl.2007.10.030  0.34
2007 Chen YR, Chen CL, Pfeiffer DR, Zweier JL. Mitochondrial complex II in the post-ischemic heart: oxidative injury and the role of protein S-glutathionylation. The Journal of Biological Chemistry. 282: 32640-54. PMID 17848555 DOI: 10.1074/Jbc.M702294200  0.392
2007 Dumitrescu C, Biondi R, Xia Y, Cardounel AJ, Druhan LJ, Ambrosio G, Zweier JL. Myocardial ischemia results in tetrahydrobiopterin (BH4) oxidation with impaired endothelial function ameliorated by BH4. Proceedings of the National Academy of Sciences of the United States of America. 104: 15081-6. PMID 17848522 DOI: 10.1073/Pnas.0702986104  0.406
2007 Villamena FA, Merle JK, Hadad CM, Zweier JL. Rate constants of hydroperoxyl radical addition to cyclic nitrones: a DFT study. The Journal of Physical Chemistry. A. 111: 9995-10001. PMID 17845014 DOI: 10.1021/Jp073615S  0.351
2007 Velayutham M, Muthukumaran RB, Sostaric JZ, McCraken J, Fishbein JC, Zweier JL. Interactions of the major metabolite of the cancer chemopreventive drug oltipraz with cytochrome c: a novel pathway for cancer chemoprevention. Free Radical Biology & Medicine. 43: 1076-85. PMID 17761303 DOI: 10.1016/J.Freeradbiomed.2007.06.022  0.34
2007 Vikram DS, Zweier JL, Kuppusamy P. Methods for noninvasive imaging of tissue hypoxia Antioxidants and Redox Signaling. 9: 1745-1756. PMID 17663644 DOI: 10.1089/Ars.2007.1717  0.314
2007 Khan M, Kutala VK, Vikram DS, Wisel S, Chacko SM, Kuppusamy ML, Mohan IK, Zweier JL, Kwiatkowski P, Kuppusamy P. Skeletal myoblasts transplanted in the ischemic myocardium enhance in situ oxygenation and recovery of contractile function. American Journal of Physiology. Heart and Circulatory Physiology. 293: H2129-39. PMID 17660391 DOI: 10.1152/Ajpheart.00677.2007  0.342
2007 Talukder MA, Kalyanasundaram A, Zhao X, Zuo L, Bhupathy P, Babu GJ, Cardounel AJ, Periasamy M, Zweier JL. Expression of SERCA isoform with faster Ca2+ transport properties improves postischemic cardiac function and Ca2+ handling and decreases myocardial infarction. American Journal of Physiology. Heart and Circulatory Physiology. 293: H2418-28. PMID 17630344 DOI: 10.1152/Ajpheart.00663.2007  0.332
2007 Villamena FA, Xia S, Merle JK, Lauricella R, Tuccio B, Hadad CM, Zweier JL. Reactivity of superoxide radical anion with cyclic nitrones: role of intramolecular H-bond and electrostatic effects. Journal of the American Chemical Society. 129: 8177-91. PMID 17564447 DOI: 10.1021/Ja0702622  0.353
2007 Zhu X, Liu B, Zhou S, Chen YR, Deng Y, Zweier JL, He G. Ischemic preconditioning prevents in vivo hyperoxygenation in postischemic myocardium with preservation of mitochondrial oxygen consumption. American Journal of Physiology. Heart and Circulatory Physiology. 293: H1442-50. PMID 17513495 DOI: 10.1152/Ajpheart.00256.2007  0.309
2007 Bobko AA, Dhimitruka I, Zweier JL, Khramtsov VV. Trityl radicals as persistent dual function pH and oxygen probes for in vivo electron paramagnetic resonance spectroscopy and imaging: concept and experiment. Journal of the American Chemical Society. 129: 7240-1. PMID 17511458 DOI: 10.1021/Ja071515U  0.343
2007 Dinkova-Kostova AT, Cheah J, Samouilov A, Zweier JL, Bozak RE, Hicks RJ, Talalay P. Phenolic Michael reaction acceptors: Combined direct and indirect antioxidant defenses against electrophiles and oxidants Medicinal Chemistry. 3: 261-268. PMID 17504197 DOI: 10.2174/157340607780620680  0.377
2007 He G, Dumitrescu C, Petryakov S, Deng Y, Kesselring E, Zweier JL. Transverse oriented electric field re-entrant resonator (TERR) with automatic tuning and coupling control for EPR spectroscopy and imaging of the beating heart. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 187: 57-65. PMID 17462925 DOI: 10.1016/J.Jmr.2007.03.020  0.31
2007 Chen CL, Zhang L, Yeh A, Chen CA, Green-Church KB, Zweier JL, Chen YR. Site-specific S-glutathiolation of mitochondrial NADH ubiquinone reductase. Biochemistry. 46: 5754-65. PMID 17444656 DOI: 10.1021/Bi602580C  0.333
2007 Lu D, Nadas J, Zhang G, Johnson W, Zweier JL, Cardounel AJ, Villamena FA, Wang PG. 4-Aryl-1,3,2-oxathiazolylium-5-olates as pH-controlled NO-donors: the next generation of S-nitrosothiols. Journal of the American Chemical Society. 129: 5503-14. PMID 17419627 DOI: 10.1021/Ja0682226  0.335
2007 Kundu TK, Hille R, Velayutham M, Zweier JL. Characterization of superoxide production from aldehyde oxidase: an important source of oxidants in biological tissues. Archives of Biochemistry and Biophysics. 460: 113-21. PMID 17353002 DOI: 10.1016/J.Abb.2006.12.032  0.386
2007 Samouilov A, Woldman YY, Zweier JL, Khramtsov VV. Magnetic resonance study of the transmembrane nitrite diffusion. Nitric Oxide : Biology and Chemistry / Official Journal of the Nitric Oxide Society. 16: 362-70. PMID 17306575 DOI: 10.1016/J.Niox.2006.12.006  0.346
2007 Zhu X, Zuo L, Cardounel AJ, Zweier JL, He G. Characterization of in vivo tissue redox status, oxygenation, and formation of reactive oxygen species in postischemic myocardium. Antioxidants & Redox Signaling. 9: 447-55. PMID 17280486 DOI: 10.1089/Ars.2006.1389  0.386
2007 Liu X, Yan Q, Baskerville KL, Zweier JL. Estimation of nitric oxide concentration in blood for different rates of generation. Evidence that intravascular nitric oxide levels are too low to exert physiological effects. The Journal of Biological Chemistry. 282: 8831-6. PMID 17267398 DOI: 10.1074/Jbc.M611684200  0.307
2007 Bobko AA, Kirilyuk IA, Grigor'ev IA, Zweier JL, Khramtsov VV. Reversible reduction of nitroxides to hydroxylamines: roles for ascorbate and glutathione. Free Radical Biology & Medicine. 42: 404-12. PMID 17210453 DOI: 10.1016/J.Freeradbiomed.2006.11.007  0.358
2007 Hassanain HH, Gregg D, Marcelo ML, Zweier JL, Souza HP, Selvakumar B, Ma Q, Moustafa-Bayoumi M, Binkley PF, Flavahan NA, Morris M, Dong C, Goldschmidt-Clermont PJ. Hypertension caused by transgenic overexpression of Rac1. Antioxidants & Redox Signaling. 9: 91-100. PMID 17115888 DOI: 10.1097/00005768-200305001-01034  0.334
2007 Zhao X, Chen YR, He G, Zhang A, Druhan LJ, Strauch AR, Zweier JL. Endothelial nitric oxide synthase (NOS3) knockout decreases NOS2 induction, limiting hyperoxygenation and conferring protection in the postischemic heart. American Journal of Physiology. Heart and Circulatory Physiology. 292: H1541-50. PMID 17114245 DOI: 10.1152/Ajpheart.00264.2006  0.353
2007 Cardounel AJ, Cui H, Samouilov A, Johnson W, Kearns P, Tsai AL, Berka V, Zweier JL. Evidence for the pathophysiological role of endogenous methylarginines in regulation of endothelial NO production and vascular function. The Journal of Biological Chemistry. 282: 879-87. PMID 17082183 DOI: 10.1074/Jbc.M603606200  0.314
2007 Han Z, Chen YR, Jones CI, Meenakshisundaram G, Zweier JL, Alevriadou BR. Shear-induced reactive nitrogen species inhibit mitochondrial respiratory complex activities in cultured vascular endothelial cells. American Journal of Physiology. Cell Physiology. 292: C1103-12. PMID 17020931 DOI: 10.1152/Ajpcell.00389.2006  0.337
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2007 Cardon TB, Druhan LJ, Chen C, Zweier JL. Acidosis, as Occurs During Myocardial Ischemia, Inhibits Nitric Oxide Synthesis But Increases Superoxide Production from Nitric Oxide Synthase The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A624-B  0.369
2007 Chen C, Chen Y, Zweier JL. Phosphorylation of Human Endothelial Nitric Oxide Synthase Modulates Nitric Oxide and Superoxide Generation from the Enzyme The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A624-A  0.343
2007 Chen C, Chen Y, Zweier JL. Superoxide Generated from Endothelial Nitric Oxide Synthase (eNOS) Modulates eNOS Function through Oxidative Modification with Protein Radical Formation The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A623-A  0.363
2006 Villamena FA, Locigno EJ, Rockenbauer A, Hadad CM, Zweier JL. Theoretical and experimental studies of the spin trapping of inorganic radicals by 5,5-dimethyl-1-pyrroline N-oxide (DMPO). 1. Carbon dioxide radical anion. The Journal of Physical Chemistry. A. 110: 13253-8. PMID 17149843 DOI: 10.1021/Jp064892M  0.32
2006 Zhu H, Zhang L, Xi X, Zweier JL, Li Y. 4-Hydroxy-2-nonenal upregulates endogenous antioxidants and phase 2 enzymes in rat H9c2 myocardiac cells: protection against overt oxidative and electrophilic injury. Free Radical Research. 40: 875-84. PMID 17015266 DOI: 10.1080/10715760600778694  0.361
2006 Presley T, Kuppusamy P, Zweier JL, Ilangovan G. Electron paramagnetic resonance oximetry as a quantitative method to measure cellular respiration: A consideration of oxygen diffusion interference Biophysical Journal. 91: 4623-4631. PMID 17012319 DOI: 10.1529/Biophysj.106.090175  0.32
2006 Xia S, Villamena FA, Hadad CM, Kuppusamy P, Li Y, Zhu H, Zweier JL. Reactivity of molecular oxygen with ethoxycarbonyl derivatives of tetrathiatriarylmethyl radicals. The Journal of Organic Chemistry. 71: 7268-79. PMID 16958520 DOI: 10.1021/Jo0610560  0.355
2006 Cao Z, Zhu H, Zhang L, Zhao X, Zweier JL, Li Y. Antioxidants and phase 2 enzymes in cardiomyocytes: Chemical inducibility and chemoprotection against oxidant and simulated ischemia-reperfusion injury. Experimental Biology and Medicine (Maywood, N.J.). 231: 1353-64. PMID 16946404 DOI: 10.1177/153537020623100809  0.387
2006 Venkatakrishnan CD, Tewari AK, Moldovan L, Cardounel AJ, Zweier JL, Kuppusamy P, Ilangovan G. Heat shock protects cardiac cells from doxorubicin-induced toxicity by activating p38 MAPK and phosphorylation of small heat shock protein 27. American Journal of Physiology. Heart and Circulatory Physiology. 291: H2680-91. PMID 16782845 DOI: 10.1152/Ajpheart.00395.2006  0.304
2006 Zhu H, Zhang L, Itoh K, Yamamoto M, Ross D, Trush MA, Zweier JL, Li Y. Nrf2 controls bone marrow stromal cell susceptibility to oxidative and electrophilic stress. Free Radical Biology & Medicine. 41: 132-43. PMID 16781461 DOI: 10.1016/J.Freeradbiomed.2006.03.020  0.322
2006 Xia Y, Berlowitz CO, Zweier JL. PIN inhibits nitric oxide and superoxide production from purified neuronal nitric oxide synthase. Biochimica Et Biophysica Acta. 1760: 1445-9. PMID 16781079 DOI: 10.1016/J.Bbagen.2006.04.007  0.356
2006 Deng Y, Pandian RP, Ahmad R, Kuppusamy P, Zweier JL. Application of magnetic field over-modulation for improved EPR linewidth measurements using probes with Lorentzian lineshape. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 181: 254-61. PMID 16759891 DOI: 10.1016/J.Jmr.2006.05.010  0.303
2006 Pandian RP, Dang V, Manoharan PT, Zweier JL, Kuppusamy P. Effect of nitrogen dioxide on the EPR property of lithium octa-n-butoxy 2,3-naphthalocyanine (LiNc-BuO) microcrystals. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 181: 154-61. PMID 16690337 DOI: 10.1016/J.Jmr.2006.04.004  0.337
2006 Biondi R, Ambrosio G, Liebgott T, Cardounel AJ, Bettini M, Tritto I, Zweier JL. Hydroxylation of D-phenylalanine as a novel approach to detect hydroxyl radicals: application to cardiac pathophysiology. Cardiovascular Research. 71: 322-30. PMID 16626670 DOI: 10.1016/J.Cardiores.2006.03.005  0.317
2006 Zweier JL, Talukder MA. The role of oxidants and free radicals in reperfusion injury. Cardiovascular Research. 70: 181-90. PMID 16580655 DOI: 10.1016/J.Cardiores.2006.02.025  0.438
2006 Chen YR, Chen CL, Yeh A, Liu X, Zweier JL. Direct and indirect roles of cytochrome b in the mediation of superoxide generation and NO catabolism by mitochondrial succinate-cytochrome c reductase. The Journal of Biological Chemistry. 281: 13159-68. PMID 16531408 DOI: 10.1074/Jbc.M513627200  0.349
2006 Li H, He G, Deng Y, Kuppusamy P, Zweier JL. In vivo proton electron double resonance imaging of the distribution and clearance of nitroxide radicals in mice. Magnetic Resonance in Medicine. 55: 669-75. PMID 16463344 DOI: 10.1002/Mrm.20804  0.346
2006 Nadolski G, Cardounel AJ, Zweier JL, Lockwood SF. The synthesis and aqueous superoxide anion scavenging of water-dispersible lutein esters. Bioorganic & Medicinal Chemistry Letters. 16: 775-81. PMID 16314095 DOI: 10.1016/J.Bmcl.2005.11.024  0.315
2006 Ilangovan G, Venkatakrishnan CD, Bratasz A, Osinbowale S, Cardounel AJ, Zweier JL, Kuppusamy P. Heat shock-induced attenuation of hydroxyl radical generation and mitochondrial aconitase activity in cardiac H9c2 cells. American Journal of Physiology. Cell Physiology. 290: C313-24. PMID 16162655 DOI: 10.1152/Ajpcell.00362.2005  0.343
2006 Tritto I, Wang P, Kuppusamy P, Giraldez R, Zweier JL, Ambrosio G. The anti-anginal drug trimetazidine reduces neutrophil-mediated cardiac reperfusion injury. Journal of Cardiovascular Pharmacology. 46: 89-98. PMID 15965360 DOI: 10.1097/01.Fjc.0000164091.81198.A3  0.363
2006 Zhao X, He G, Chen YR, Pandian RP, Kuppusamy P, Zweier JL. Endothelium-derived nitric oxide regulates postischemic myocardial oxygenation and oxygen consumption by modulation of mitochondrial electron transport. Circulation. 111: 2966-72. PMID 15939832 DOI: 10.1161/Circulationaha.104.527226  0.398
2006 Pandian RP, Kim YI, Woodward PM, Zweier JL, Manoharan PT, Kuppusamy P. The open molecular framework of paramagnetic lithium octabutoxy-naphthalocyanine: Implications for the detection of oxygen and nitric oxide using EPR spectroscopy Journal of Materials Chemistry. 16: 3609-3618. DOI: 10.1039/B517976A  0.362
2006 Dumitrescu C, He G, Zweier JL. P059. Ischemic preconditioning improves cardiac function by increasing mitochondrial oxygen metabolism in the postischemic heart Nitric Oxide. 14: 36. DOI: 10.1016/J.Niox.2006.04.121  0.327
2005 Villamena FA, Merle JK, Hadad CM, Zweier JL. Superoxide radical anion adduct of 5,5-dimethyl-1-pyrroline N-oxide (DMPO). 2. The thermodynamics of decay and EPR spectral properties. The Journal of Physical Chemistry. A. 109: 6089-98. PMID 16833946 DOI: 10.1021/Jp0524330  0.361
2005 Villamena FA, Merle JK, Hadad CM, Zweier JL. Superoxide radical anion adduct of 5,5-dimethyl-1-pyrroline n-oxide (DMPO). 1. The thermodynamics of formation and its acidity. The Journal of Physical Chemistry. A. 109: 6083-8. PMID 16833945 DOI: 10.1021/Jp052431F  0.332
2005 Villamena FA, Hadad CM, Zweier JL. Comparative DFT study of the spin trapping of methyl, mercapto, hydroperoxy, superoxide, and nitric oxide radicals by various substituted cyclic nitrones. The Journal of Physical Chemistry. A. 109: 1662-74. PMID 16833491 DOI: 10.1021/Jp0451492  0.342
2005 Chen YR, Chen CL, Zhang L, Green-Church KB, Zweier JL. Superoxide generation from mitochondrial NADH dehydrogenase induces self-inactivation with specific protein radical formation. The Journal of Biological Chemistry. 280: 37339-48. PMID 16150735 DOI: 10.1074/Jbc.M503936200  0.351
2005 Locigno EJ, Zweier JL, Villamena FA. Nitric oxide release from the unimolecular decomposition of the superoxide radical anion adduct of cyclic nitrones in aqueous medium. Organic & Biomolecular Chemistry. 3: 3220-7. PMID 16106305 DOI: 10.1039/B507530K  0.391
2005 Chen YR, Chen CL, Liu X, He G, Zweier JL. Involvement of phospholipid, biomembrane integrity, and NO peroxidase activity in the NO catabolism by cytochrome c oxidase. Archives of Biochemistry and Biophysics. 439: 200-10. PMID 15963451 DOI: 10.1016/J.Abb.2005.05.014  0.336
2005 Velayutham M, Villamena FA, Navamal M, Fishbein JC, Zweier JL. Glutathione-mediated formation of oxygen free radicals by the major metabolite of oltipraz. Chemical Research in Toxicology. 18: 970-5. PMID 15962931 DOI: 10.1021/Tx049687H  0.383
2005 Zhu H, Itoh K, Yamamoto M, Zweier JL, Li Y. Role of Nrf2 signaling in regulation of antioxidants and phase 2 enzymes in cardiac fibroblasts: protection against reactive oxygen and nitrogen species-induced cell injury. Febs Letters. 579: 3029-36. PMID 15896789 DOI: 10.1016/J.Febslet.2005.04.058  0.375
2005 Li H, Cui H, Liu X, Zweier JL. Xanthine oxidase catalyzes anaerobic transformation of organic nitrates to nitric oxide and nitrosothiols: characterization of this mechanism and the link between organic nitrate and guanylyl cyclase activation. The Journal of Biological Chemistry. 280: 16594-600. PMID 15695823 DOI: 10.1074/Jbc.M411905200  0.305
2005 Velayutham M, Villamena FA, Fishbein JC, Zweier JL. Cancer chemopreventive oltipraz generates superoxide anion radical. Archives of Biochemistry and Biophysics. 435: 83-8. PMID 15680910 DOI: 10.1016/J.Abb.2004.11.028  0.387
2005 Cardounel AJ, Xia Y, Zweier JL. Endogenous methylarginines modulate superoxide as well as nitric oxide generation from neuronal nitric-oxide synthase: differences in the effects of monomethyl- and dimethylarginines in the presence and absence of tetrahydrobiopterin. The Journal of Biological Chemistry. 280: 7540-9. PMID 15574418 DOI: 10.1074/Jbc.M410241200  0.322
2004 Villamena FA, Rockenbauer A, Gallucci J, Velayutham M, Hadad CM, Zweier JL. Spin trapping by 5-carbamoyl-5-methyl-1-pyrroline N-oxide (AMPO): theoretical and experimental studies. The Journal of Organic Chemistry. 69: 7994-8004. PMID 15527282 DOI: 10.1021/Jo049244I  0.329
2004 Chen YR, Chen CL, Liu X, Li H, Zweier JL, Mason RP. Involvement of protein radical, protein aggregation, and effects on NO metabolism in the hypochlorite-mediated oxidation of mitochondrial cytochrome c. Free Radical Biology & Medicine. 37: 1591-603. PMID 15477010 DOI: 10.1016/J.Freeradbiomed.2004.07.013  0.34
2004 Ilangovan G, Osinbowale S, Bratasz A, Bonar M, Cardounel AJ, Zweier JL, Kuppusamy P. Heat shock regulates the respiration of cardiac H9c2 cells through upregulation of nitric oxide synthase. American Journal of Physiology. Cell Physiology. 287: C1472-81. PMID 15475520 DOI: 10.1152/Ajpcell.00103.2004  0.307
2004 Samouilov A, Roubaud V, Kuppusamy P, Zweier JL. Kinetic analysis-based quantitation of free radical generation in EPR spin trapping Analytical Biochemistry. 334: 145-154. PMID 15464963 DOI: 10.1016/J.Ab.2004.07.026  0.345
2004 Kuppusamy P, Zweier JL. Cardiac applications of EPR imaging Nmr in Biomedicine. 17: 226-239. PMID 15366025 DOI: 10.1002/Nbm.912  0.356
2004 Ilangovan G, Zweier JL, Kuppusamy P. Mechanism of oxygen-induced EPR line broadening in lithium phthalocyanine microcrystals Journal of Magnetic Resonance. 170: 42-48. PMID 15324756 DOI: 10.1016/J.Jmr.2004.05.018  0.336
2004 Liu X, Cheng C, Zorko N, Cronin S, Chen YR, Zweier JL. Biphasic modulation of vascular nitric oxide catabolism by oxygen. American Journal of Physiology. Heart and Circulatory Physiology. 287: H2421-6. PMID 15271663 DOI: 10.1152/Ajpheart.00487.2004  0.369
2004 Jackson HL, Cardounel AJ, Zweier JL, Lockwood SF. Synthesis, characterization, and direct aqueous superoxide anion scavenging of a highly water-dispersible astaxanthin-amino acid conjugate. Bioorganic & Medicinal Chemistry Letters. 14: 3985-91. PMID 15225712 DOI: 10.1016/J.Bmcl.2004.05.038  0.31
2004 Crowther JE, Kutala VK, Kuppusamy P, Ferguson JS, Beharka AA, Zweier JL, McCormack FX, Schlesinger LS. Pulmonary surfactant protein a inhibits macrophage reactive oxygen intermediate production in response to stimuli by reducing NADPH oxidase activity. Journal of Immunology (Baltimore, Md. : 1950). 172: 6866-74. PMID 15153505 DOI: 10.4049/Jimmunol.172.11.6866  0.319
2004 Villamena FA, Zweier JL. Detection of reactive oxygen and nitrogen species by EPR spin trapping. Antioxidants & Redox Signaling. 6: 619-29. PMID 15130289 DOI: 10.1089/152308604773934387  0.358
2004 Foss BJ, Sliwka HR, Partali V, Cardounel AJ, Zweier JL, Lockwood SF. Direct superoxide anion scavenging by a highly water-dispersible carotenoid phospholipid evaluated by electron paramagnetic resonance (EPR) spectroscopy. Bioorganic & Medicinal Chemistry Letters. 14: 2807-12. PMID 15125937 DOI: 10.1016/J.Bmcl.2004.03.061  0.359
2004 Ilangovan G, Liebgott T, Kutala VK, Petryakov S, Zweier JL, Kuppusamy P. EPR oximetry in the beating heart: myocardial oxygen consumption rate as an index of postischemic recovery. Magnetic Resonance in Medicine. 51: 835-42. PMID 15065258 DOI: 10.1002/Mrm.20000  0.347
2004 Ilangovan G, Zweier JL, Kuppusamy P. Microximetry: Simultaneous Determination of Oxygen Consumption and Free Radical Production Using Electron Paramagnetic Resonance Spectroscopy Methods in Enzymology. 381: 747-762. PMID 15063710 DOI: 10.1016/S0076-6879(04)81048-6  0.374
2004 Kutala VK, Parinandi NL, Zweier JL, Kuppusamy P. Reaction of superoxide with trityl radical: Implications for the determination of superoxide by spectrophotometry Archives of Biochemistry and Biophysics. 424: 81-88. PMID 15019839 DOI: 10.1016/J.Abb.2004.01.020  0.373
2004 Villamena FA, Hadad CM, Zweier JL. Theoretical study of the spin trapping of hydroxyl radical by cyclic nitrones: a density functional theory approach. Journal of the American Chemical Society. 126: 1816-29. PMID 14871114 DOI: 10.1021/Ja038838K  0.314
2004 Li H, Samouilov A, Liu X, Zweier JL. Characterization of the effects of oxygen on xanthine oxidase-mediated nitric oxide formation. The Journal of Biological Chemistry. 279: 16939-46. PMID 14766900 DOI: 10.1074/Jbc.M314336200  0.384
2004 Chen YR, Chen CL, Chen W, Zweier JL, Augusto O, Radi R, Mason RP. Formation of protein tyrosine ortho-semiquinone radical and nitrotyrosine from cytochrome c-derived tyrosyl radical. The Journal of Biological Chemistry. 279: 18054-62. PMID 14761966 DOI: 10.1074/Jbc.M307706200  0.343
2004 Tiravanti E, Samouilov A, Zweier JL. Nitrosyl-heme complexes are formed in the ischemic heart: evidence of nitrite-derived nitric oxide formation, storage, and signaling in post-ischemic tissues. The Journal of Biological Chemistry. 279: 11065-73. PMID 14704151 DOI: 10.1074/Jbc.M311908200  0.401
2004 Rizzi C, Samouilov A, Kutala VK, Parinandi NL, Zweier JL, Kuppusamy P. Application of a trityl-based radical probe for measuring superoxide. Free Radical Biology & Medicine. 35: 1608-18. PMID 14680684 DOI: 10.1016/J.Freeradbiomed.2003.09.014  0.375
2004 Khramtsov VV, Grigor’ev IA, Lurie DJ, Foster MA, Zweier JL, Kuppusamy P. Spin pH and SH probes: enhancing functionality of EPR-based techniques Spectroscopy. 18: 213-225. DOI: 10.1155/2004/870630  0.314
2004 Xia Y, Biondi R, Liebgott T, Paolocci N, Cardounel A, Ambrosio G, Zweier JL. 1136-82 Tetrahydrobiopterin depletion leads to endothelial nitric oxide synthase dysfunction in ischemic hearts Journal of the American College of Cardiology. 43: A294. DOI: 10.1016/S0735-1097(04)91245-4  0.363
2003 Pandian RP, Kutala VK, Parinandi NL, Zweier JL, Kuppusamy P. Measurement of oxygen consumption in mouse aortic endothelial cells using a microparticulate oximetry probe Archives of Biochemistry and Biophysics. 420: 169-175. PMID 14622987 DOI: 10.1016/J.Abb.2003.09.008  0.349
2003 Pandian RP, Parinandi NL, Ilangovan G, Zweier JL, Kuppusamy P. Novel particulate spin probe for targeted determination of oxygen in cells and tissues Free Radical Biology and Medicine. 35: 1138-1148. PMID 14572616 DOI: 10.1016/S0891-5849(03)00496-9  0.341
2003 Zweier JL, He G, Samouilov A, Kuppusamy P. EPR spectroscopy and imaging of oxygen: Applications to the gastrointestinal tract Advances in Experimental Medicine and Biology. 530: 123-131. PMID 14562710 DOI: 10.1007/978-1-4615-0075-9_12  0.31
2003 Muscoli C, Cuzzocrea S, Riley DP, Zweier JL, Thiemermann C, Wang ZQ, Salvemini D. On the selectivity of superoxide dismutase mimetics and its importance in pharmacological studies. British Journal of Pharmacology. 140: 445-60. PMID 14522841 DOI: 10.1038/Sj.Bjp.0705430  0.314
2003 Roy S, Khanna S, Wallace WA, Lappalainen J, Rink C, Cardounel AJ, Zweier JL, Sen CK. Characterization of perceived hyperoxia in isolated primary cardiac fibroblasts and in the reoxygenated heart. The Journal of Biological Chemistry. 278: 47129-35. PMID 12952964 DOI: 10.1074/Jbc.M308703200  0.338
2003 Cardounel AJ, Dumitrescu C, Zweier JL, Lockwood SF. Direct superoxide anion scavenging by a disodium disuccinate astaxanthin derivative: Relative efficacy of individual stereoisomers versus the statistical mixture of stereoisomers by electron paramagnetic resonance imaging. Biochemical and Biophysical Research Communications. 307: 704-12. PMID 12893281 DOI: 10.1016/S0006-291X(03)01248-8  0.336
2003 Liebgott T, Li H, Deng Y, Zweier JL. Proton electron double resonance imaging (PEDRI) of the isolated beating rat heart. Magnetic Resonance in Medicine. 50: 391-9. PMID 12876716 DOI: 10.1002/Mrm.10534  0.352
2003 Cai Z, Manalo DJ, Wei G, Rodriguez ER, Fox-Talbot K, Lu H, Zweier JL, Semenza GL. Hearts from rodents exposed to intermittent hypoxia or erythropoietin are protected against ischemia-reperfusion injury. Circulation. 108: 79-85. PMID 12796124 DOI: 10.1161/01.Cir.0000078635.89229.8A  0.317
2003 Velayutham M, Li H, Kuppusamy P, Zweier JL. Mapping ischemic risk region and necrosis in the isolated heart using EPR imaging Magnetic Resonance in Medicine. 49: 1181-1187. PMID 12768597 DOI: 10.1002/Mrm.10473  0.33
2003 Li H, Samouilov A, Liu X, Zweier JL. Characterization of the magnitude and kinetics of xanthine oxidase-catalyzed nitrate reduction: evaluation of its role in nitrite and nitric oxide generation in anoxic tissues. Biochemistry. 42: 1150-9. PMID 12549937 DOI: 10.1021/Bi026385A  0.373
2003 Parinandi NL, Kleinberg MA, Usatyuk PV, Cummings RJ, Pennathur A, Cardounel AJ, Zweier JL, Garcia JG, Natarajan V. Hyperoxia-induced NAD(P)H oxidase activation and regulation by MAP kinases in human lung endothelial cells. American Journal of Physiology. Lung Cellular and Molecular Physiology. 284: L26-38. PMID 12388366 DOI: 10.1152/Ajplung.00123.2002  0.327
2003 Janiszewski M, Souza HP, Liu X, Pedro MA, Zweier JL, Laurindo FR. Overestimation of NADH-driven vascular oxidase activity due to lucigenin artifacts. Free Radical Biology & Medicine. 32: 446-53. PMID 11864784 DOI: 10.1016/S0891-5849(01)00828-0  0.375
2002 Song Y, Cardounel AJ, Zweier JL, Xia Y. Inhibition of superoxide generation from neuronal nitric oxide synthase by heat shock protein 90: implications in NOS regulation. Biochemistry. 41: 10616-22. PMID 12186546 DOI: 10.1021/Bi026060U  0.3
2002 He G, Samouilov A, Kuppusamy P, Zweier JL. In vivo imaging of free radicals: Applications from mouse to man Molecular and Cellular Biochemistry. 234: 359-367. PMID 12162454 DOI: 10.1023/A:1015994629341  0.331
2002 Samouilov A, Zweier JL. Analytical implications of iron dithiocarbamates for measurement of nitric oxide. Methods in Enzymology. 352: 506-22. PMID 12125375 DOI: 10.1016/S0076-6879(02)52044-9  0.302
2002 Li Y, Seacat A, Kuppusamy P, Zweier JL, Yager JD, Trush MA. Copper redox-dependent activation of 2-tert-butyl(1,4)hydroquinone: formation of reactive oxygen species and induction of oxidative DNA damage in isolated DNA and cultured rat hepatocytes. Mutation Research. 518: 123-33. PMID 12113763 DOI: 10.1016/S1383-5718(02)00073-6  0.331
2002 Li H, Ma L, Hsia CJC, Zweier JL, Kuppusamy P. Polynitroxyl-albumin (PNA) enhances myocardial infarction therapeutic effect of Tempol in rat hearts subjected to regional ischemia-reperfusion Free Radical Biology and Medicine. 32: 712-719. PMID 11937297 DOI: 10.1016/S0891-5849(02)00762-1  0.33
2002 He G, Deng Y, Li H, Kuppusamy P, Zweier JL. EPR/NMR co-imaging for anatomic registration of free-radical images. Magnetic Resonance in Medicine. 47: 571-8. PMID 11870845 DOI: 10.1002/Mrm.10077  0.321
2002 Ilangovan G, Manivannan A, Li H, Yanagi H, Zweier JL, Kuppusamy P. A naphthalocyanine-based EPR probe for localized measurements of tissue oxygenation. Free Radical Biology & Medicine. 32: 139-47. PMID 11796202 DOI: 10.1016/S0891-5849(01)00784-5  0.337
2002 Souza HP, Liu X, Samouilov A, Kuppusamy P, Laurindo FRM, Zweier JL. Quantitation of superoxide generation and substrate utilization by vascular NAD(P)H oxidase American Journal of Physiology - Heart and Circulatory Physiology. 282. PMID 11788393 DOI: 10.1152/Ajpheart.00482.2001  0.334
2002 Lurie DJ, Li H, Petryakov S, Zweier JL. Development of a PEDRI free-radical imager using a 0.38 T clinical MRI system. Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 47: 181-6. PMID 11754457 DOI: 10.1002/Mrm.10029  0.303
2002 Ellis SJ, Velayutham M, Velan SS, Petersen EF, Zweier JL, Kuppusamy P, Spencer RG. EPR oxygen mapping (EPROM) of engineered cartilage grown in a hollow-fiber bioreactor. Magnetic Resonance in Medicine. 46: 819-26. PMID 11590660 DOI: 10.1002/Mrm.1262  0.342
2002 Villamena FA, Zweier JL. Superoxide radical trapping and spin adduct decay of 5-tert-butoxycarbonyl-5-methyl-1-pyrroline N-oxide (BocMPO): kinetics and theoretical analysis Journal of the Chemical Society-Perkin Transactions 1. 1340-1344. DOI: 10.1039/B201734B  0.347
2002 Ilangovan G, Pal R, Zweier JL, Kuppusamy P. Electrochemical preparation and EPR studies of lithium phthalocyanine. 4. Effect of nitric oxide Journal of Physical Chemistry B. 106: 11929-11935. DOI: 10.1021/Jp026360L  0.316
2002 Shankar R, Kuppusamy P, Zhou Y, Goldson A, Zweier J, Sridhar R. In vivo measurements of tumor oxygenation and metabolism using electron paramagnetic resonance spectroscopy/imaging International Journal of Radiation Oncology*Biology*Physics. 54: 118. DOI: 10.1016/S0360-3016(02)03259-5  0.305
2001 Song Y, Zweier JL, Xia Y. Determination of the enhancing action of HSP90 on neuronal nitric oxide synthase by EPR spectroscopy. American Journal of Physiology. Cell Physiology. 281: C1819-24. PMID 11698240 DOI: 10.1152/Ajpcell.2001.281.6.C1819  0.309
2001 Duilio C, Ambrosio G, Kuppusamy P, DiPaula A, Becker LC, Zweier JL. Neutrophils are primary source of O2 radicals during reperfusion after prolonged myocardial ischemia. American Journal of Physiology. Heart and Circulatory Physiology. 280: H2649-57. PMID 11356621 DOI: 10.1152/Ajpheart.2001.280.6.H2649  0.412
2001 Paolocci N, Biondi R, Bettini M, Lee CI, Berlowitz CO, Rossi R, Xia Y, Ambrosio G, L'Abbate A, Kass DA, Zweier JL. Oxygen radical-mediated reduction in basal and agonist-evoked NO release in isolated rat heart. Journal of Molecular and Cellular Cardiology. 33: 671-9. PMID 11341236 DOI: 10.1006/Jmcc.2000.1334  0.364
2001 Li H, Samouilov A, Liu X, Zweier JL. Characterization of the magnitude and kinetics of xanthine oxidase-catalyzed nitrite reduction. Evaluation of its role in nitric oxide generation in anoxic tissues. The Journal of Biological Chemistry. 276: 24482-9. PMID 11312267 DOI: 10.1074/Jbc.M011648200  0.379
2001 Zweier JL, Fertmann J, Wei G. Nitric oxide and peroxynitrite in postischemic myocardium. Antioxidants & Redox Signaling. 3: 11-22. PMID 11294189 DOI: 10.1089/152308601750100443  0.423
2001 Kuppusamy P, Shankar RA, Roubaud VM, Zweier JL. Whole body detection and imaging of nitric oxide generation in mice following cardiopulmonary arrest: Detection of intrinsic nitrosoheme complexes0 Magnetic Resonance in Medicine. 45: 700-707. PMID 11283999 DOI: 10.1002/Mrm.1093  0.378
2001 Souza HP, Laurindo FR, Ziegelstein RC, Berlowitz CO, Zweier JL. Vascular NAD(P)H oxidase is distinct from the phagocytic enzyme and modulates vascular reactivity control. American Journal of Physiology. Heart and Circulatory Physiology. 280: H658-67. PMID 11158964 DOI: 10.1152/Ajpheart.2001.280.2.H658  0.374
2001 Janiszewski M, Pedro M, Souza H, Zweier J, Laurindo F. Artifacts related to lucigenin chemiluminescence for superoxide detection in a vascular system Critical Care. 5: 20. DOI: 10.1186/Cc1353  0.386
2000 Zorov DB, Filburn CR, Klotz LO, Zweier JL, Sollott SJ. Reactive oxygen species (ROS)-induced ROS release: A new phenomenon accompanying induction of the mitochondrial permeability transition in cardiac myocytes Journal of Experimental Medicine. 192: 1001-1014. PMID 11015441 DOI: 10.1084/Jem.192.7.1001  0.337
2000 Velan SS, Spencer RGS, Zweier JL, Kuppusamy P. Electron paramagnetic resonance oxygen mapping (EPROM): Direct visualization of oxygen concentration in tissue Magnetic Resonance in Medicine. 43: 804-809. PMID 10861874 DOI: 10.1002/1522-2594(200006)43:6<804::Aid-Mrm5>3.0.Co;2-B  0.326
2000 Giraldez RR, Panda A, Zweier JL. Endothelial dysfunction does not require loss of endothelial nitric oxide synthase. American Journal of Physiology. Heart and Circulatory Physiology. 278: H2020-7. PMID 10843901 DOI: 10.1152/Ajpheart.2000.278.6.H2020  0.371
2000 Sanders SP, Bassett DJP, Harrison SJ, Pearse D, Zweier JL, Becker PM. Measurements of free radicals in isolated, ischemic lungs and lung mitochondria Lung. 178: 105-118. PMID 10773136 DOI: 10.1007/S004080000013  0.378
2000 Hu Q, Zheng G, Zweier JL, Deshpande S, Irani K, Ziegelstein RC. NADPH oxidase activation increases the sensitivity of intracellular Ca2+ stores to inositol 1,4,5-trisphosphate in human endothelial cells. The Journal of Biological Chemistry. 275: 15749-57. PMID 10747906 DOI: 10.1074/Jbc.M000381200  0.309
2000 Sankarapandi S, Zweier JL. Evidence against the generation of free hydroxyl radicals from the interaction of copper,zinc-superoxide dismutase and hydrogen peroxide. The Journal of Biological Chemistry. 274: 34576-83. PMID 10574920 DOI: 10.1074/Jbc.274.49.34576  0.365
1999 Wei G, Dawson VL, Zweier JL. Role of neuronal and endothelial nitric oxide synthase in nitric oxide generation in the brain following cerebral ischemia. Biochimica Et Biophysica Acta. 1455: 23-34. PMID 10524226 DOI: 10.1016/S0925-4439(99)00051-4  0.347
1999 Salvemini D, Wang ZQ, Zweier JL, Samouilov A, Macarthur H, Misko TP, Currie MG, Cuzzocrea S, Sikorski JA, Riley DP. A nonpeptidyl mimic of superoxide dismutase with therapeutic activity in rats Science. 286: 304-306. PMID 10514375 DOI: 10.1126/Science.286.5438.304  0.347
1999 Lu R, Wang P, Wartofsky L, Sutton BD, Zweier JL, Bahn RS, Garrity J, Burman KD. Oxygen free radicals in interleukin-1beta-induced glycosaminoglycan production by retro-ocular fibroblasts from normal subjects and Graves' ophthalmopathy patients. Thyroid : Official Journal of the American Thyroid Association. 9: 297-303. PMID 10211608 DOI: 10.1089/Thy.1999.9.297  0.302
1999 He G, Shankar RA, Chzhan M, Samouilov A, Kuppusamy P, Zweier JL. Noninvasive measurement of anatomic structure and intraluminal oxygenation in the gastrointestinal tract of living mice with spatial and spectral EPR imaging. Proceedings of the National Academy of Sciences of the United States of America. 96: 4586-91. PMID 10200306 DOI: 10.1073/Pnas.96.8.4586  0.309
1999 Sankarapandi S, Zweier JL. Bicarbonate is required for the peroxidase function of Cu, Zn-superoxide dismutase at physiological pH. The Journal of Biological Chemistry. 274: 1226-32. PMID 9880490 DOI: 10.1074/Jbc.274.3.1226  0.326
1999 Kuppusamy P, Wang P, Shankar RA, Ma L, Trimble CE, Hsia CJ, Zweier JL. In vivo topical EPR spectroscopy and imaging of nitroxide free radicals and polynitroxyl-albumin. Magnetic Resonance in Medicine. 40: 806-11. PMID 9840823 DOI: 10.1002/Mrm.1910400604  0.327
1998 Krishna MC, Kuppusamy P, Afeworki M, Zweier JL, Cook JA, Subramanian S, Mitchell JB. Development of functional electron paramagnetic resonance imaging. Breast Disease. 10: 209-20. PMID 15687576 DOI: 10.3233/Bd-1998-103-420  0.301
1998 Xia Y, Tsai AL, Berka V, Zweier JL. Superoxide generation from endothelial nitric-oxide synthase. A Ca2+/calmodulin-dependent and tetrahydrobiopterin regulatory process. The Journal of Biological Chemistry. 273: 25804-8. PMID 9748253 DOI: 10.1074/Jbc.273.40.25804  0.346
1998 Hu Q, Xia Y, Corda S, Zweier JL, Ziegelstein RC. Hydrogen peroxide decreases pHi in human aortic endothelial cells by inhibiting Na+/H+ exchange. Circulation Research. 83: 644-51. PMID 9742060 DOI: 10.1161/01.Res.83.6.644  0.313
1998 Ha HC, Sirisoma NS, Kuppusamy P, Zweier JL, Woster PM, Casero RA. The natural polyamine spermine functions directly as a free radical scavenger Proceedings of the National Academy of Sciences of the United States of America. 95: 11140-11145. PMID 9736703 DOI: 10.1073/Pnas.95.19.11140  0.346
1998 Samouilov A, Kuppusamy P, Zweier JL. Evaluation of the magnitude and rate of nitric oxide production from nitrite in biological systems Archives of Biochemistry and Biophysics. 357: 1-7. PMID 9721176 DOI: 10.1006/Abbi.1998.0785  0.358
1998 Xia Y, Roman LJ, Masters BSS, Zweier JL. Inducible nitric-oxide synthase generates superoxide from the reductase domain Journal of Biological Chemistry. 273: 22635-22639. PMID 9712892 DOI: 10.1074/Jbc.273.35.22635  0.349
1998 Kuppusamy P, Shankar RA, Zweier JL. In vivo measurement of arterial and venous oxygenation in the rat using 3D spectral-spatial electron paramagnetic resonance imaging Physics in Medicine and Biology. 43: 1837-1844. PMID 9703045 DOI: 10.1088/0031-9155/43/7/003  0.337
1998 Zweier JL, Chzhan M, Samouilov A, Kuppusamy P. Electron paramagnetic resonance imaging of the rat heart Physics in Medicine and Biology. 43: 1823-1835. PMID 9703044 DOI: 10.1088/0031-9155/43/7/002  0.39
1998 Sankarapandi S, Zweier JL, Mukherjee G, Quinn MT, Huso DL. Measurement and characterization of superoxide generation in microglial cells: evidence for an NADPH oxidase-dependent pathway. Archives of Biochemistry and Biophysics. 353: 312-21. PMID 9606965 DOI: 10.1006/Abbi.1998.0658  0.388
1998 Samouilov A, Zweier JL. Development of chemiluminescence-based methods for specific quantitation of nitrosylated thiols. Analytical Biochemistry. 258: 322-30. PMID 9570848 DOI: 10.1006/Abio.1998.2609  0.315
1998 Wang P, Chen H, Qin H, Sankarapandi S, Becher MW, Wong PC, Zweier JL. Overexpression of human copper, zinc-superoxide dismutase (SOD1) prevents postischemic injury. Proceedings of the National Academy of Sciences of the United States of America. 95: 4556-60. PMID 9539776 DOI: 10.1073/Pnas.95.8.4556  0.382
1998 Roubaud V, Sankarapandi S, Kuppusamy P, Tordo P, Zweier JL. Quantitative measurement of superoxide generation and oxygen consumption from leukocytes using electron paramagnetic resonance spectroscopy Analytical Biochemistry. 257: 210-217. PMID 9514781 DOI: 10.1006/Abio.1997.2542  0.392
1998 Hu Q, Corda S, Zweier JL, Capogrossi MC, Ziegelstein RC. Hydrogen peroxide induces intracellular calcium oscillations in human aortic endothelial cells. Circulation. 97: 268-75. PMID 9462529 DOI: 10.1161/01.Cir.97.3.268  0.317
1998 Li Y, Zhu H, Kuppusamy P, Roubaud V, Zweier JL, Trush MA. Validation of lucigenin (bis-N-methylacridinium) as a chemilumigenic probe for detecting superoxide anion radical production by enzymatic and cellular systems. The Journal of Biological Chemistry. 273: 2015-23. PMID 9442038 DOI: 10.1074/Jbc.273.4.2015  0.32
1998 Giraldez R, Sun B, Zweier J, Becker L. Impaired endothelial-dependent vasodilation in viable postischemic myocardium results from reduced activity of nitric oxide synthase Journal of the American College of Cardiology. 31: 187. DOI: 10.1016/S0735-1097(98)81452-6  0.351
1997 Xia Y, Zweier JL. Direct measurement of nitric oxide generation from nitric oxide synthase. Proceedings of the National Academy of Sciences of the United States of America. 94: 12705-10. PMID 9356514 DOI: 10.1073/Pnas.94.23.12705  0.341
1997 Seacat AM, Kuppusamy P, Zweier JL, Yager JD. ESR identification of free radicals formed from the oxidation of catechol estrogens by Cu2+ Archives of Biochemistry and Biophysics. 347: 45-52. PMID 9344463 DOI: 10.1006/Abbi.1997.0323  0.317
1997 Xia Y, Zweier JL. Superoxide and peroxynitrite generation from inducible nitric oxide synthase in macrophages. Proceedings of the National Academy of Sciences of the United States of America. 94: 6954-8. PMID 9192673 DOI: 10.1073/Pnas.94.13.6954  0.329
1997 Roubaud V, Sankarapandi S, Kuppusamy P, Tordo P, Zweier JL. Quantitative measurement of superoxide generation using the spin trap 5- (diethoxyphosphoryl)-5-methyl-1-pyrroline-N-oxide Analytical Biochemistry. 247: 404-411. PMID 9177705 DOI: 10.1006/Abio.1997.2067  0.376
1997 Xu KY, Zweier JL, Becker LC. Hydroxyl radical inhibits sarcoplasmic reticulum Ca(2+)-ATPase function by direct attack on the ATP binding site. Circulation Research. 80: 76-81. PMID 8978325 DOI: 10.1161/01.Res.80.1.76  0.321
1997 Wang P, Zweier JL. Measurement of nitric oxide and peroxynitrite generation in the postischemic heart. Evidence for peroxynitrite-mediated reperfusion injury. The Journal of Biological Chemistry. 271: 29223-30. PMID 8910581 DOI: 10.1074/jbc.271.46.29223  0.313
1996 Primiano T, Kensler TW, Kuppusamy P, Zweier JL, Sutter TR. Induction of hepatic heme oxygenase-1 and ferritin in rats by cancer chemopreventive dithiolethiones Carcinogenesis. 17: 2291-2296. PMID 8968040 DOI: 10.1093/Carcin/17.11.2291  0.301
1996 Kuppusamy P, Wang P, Samouilov A, Zweier JL. Spatial mapping of nitric oxide generation in the ischemic heart using electron paramagnetic resonance imaging Magnetic Resonance in Medicine. 36: 212-218. PMID 8843374 DOI: 10.1002/Mrm.1910360207  0.373
1996 Kuppusamy P, Chzhan M, Wang P, Zweier JL. Three-dimensional gated EPR imaging of the beating heart: Time-resolved measurements of free radical distribution during the cardiac contractile cycle Magnetic Resonance in Medicine. 35: 323-328. PMID 8699943 DOI: 10.1002/Mrm.1910350309  0.334
1996 Xia Y, Dawson VL, Dawson TM, Snyder SH, Zweier JL. Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury. Proceedings of the National Academy of Sciences of the United States of America. 93: 6770-4. PMID 8692893 DOI: 10.1073/Pnas.93.13.6770  0.344
1996 Kuppusamy P, Wang P, Zweier JL, Krishna MC, Mitchell JB, Ma L, Trimble CE, Hsia CJ. Electron paramagnetic resonance imaging of rat heart with nitroxide and polynitroxyl-albumin. Biochemistry. 35: 7051-7. PMID 8679530 DOI: 10.1021/Bi952857S  0.38
1996 Fraticelli A, Serrano CV, Bochner BS, Capogrossi MC, Zweier JL. Hydrogen peroxide and superoxide modulate leukocyte adhesion molecule expression and leukocyte endothelial adhesion. Biochimica Et Biophysica Acta. 1310: 251-9. PMID 8599602 DOI: 10.1016/0167-4889(95)00169-7  0.393
1996 Zweier JL, Samouilov A, Chzhan M. Measurement of nitric oxide with a solid-state-char EPR probe. Journal of Magnetic Resonance. Series B. 109: 259-63. PMID 8542194 DOI: 10.1006/Jmrb.1995.9997  0.356
1996 Zweier JL, Chzhan M, Wang P, Kupppusamy P. Spatial and spectral-spatial EPR imaging of free radicals and oxygen in the heart Research On Chemical Intermediates. 22: 615-624. DOI: 10.1163/156856796X00241  0.37
1996 Kuppusamy P, Ohnishi ST, Numagami Y, Ohnishi T, Zweier JL. Imaging of nitric oxide generation in the rat brain Research On Chemical Intermediates. 22: 605-613. DOI: 10.1163/156856796X00232  0.365
1996 Zweier JL, Wang P, Samouilov A, Kuppusamy P. Enzyme independent formation of nitric oxide is triggered during myocardial ischemia and results in post ischemic injury Journal of the American College of Cardiology. 27: 102-103. DOI: 10.1016/S0735-1097(96)80621-8  0.356
1996 Giraldez RR, Broderick R, Xia Y, Sanders SP, Zweier JL. Loss of nitric oxide synthase activity in the post-ischemic heart: Evidence for acidosis induced enzyme denaturation Journal of the American College of Cardiology. 27: 101. DOI: 10.1016/S0735-1097(96)80616-4  0.359
1996 Dulio C, Ambrosio G, Kuppusamy P, Becker LC, Zweier JL. In vivo evidence that neutrophils become activated and generate oxygen radicals in reperfused hearts Journal of the American College of Cardiology. 27: 33. DOI: 10.1016/S0735-1097(96)80323-8  0.379
1995 Zweier JL, Wang P, Kuppusamy P. Direct measurement of nitric oxide generation in the ischemic heart using electron paramagnetic resonance spectroscopy Journal of Biological Chemistry. 270: 304-307. PMID 7814391 DOI: 10.1074/jbc.270.1.304  0.3
1995 Sanders SP, Zweier JL, Harrison SJ, Trush MA, Rembish SJ, Liu MC. Spontaneous oxygen radical production at sites of antigen challenge in allergic subjects American Journal of Respiratory and Critical Care Medicine. 151: 1725-1733. PMID 7767513 DOI: 10.1164/Ajrccm.151.6.7767513  0.334
1995 Kuppusamy P, Wang P, Zweier JL. Three‐dimensional spatial EPR imaging of the rat heart Magnetic Resonance in Medicine. 34: 99-105. PMID 7674904 DOI: 10.1002/Mrm.1910340115  0.322
1995 Kuppusamy P, Wang P, Zweier JL. Evaluation of nitroxides for the study of myocardial metabolism and oxygenation Magnetic Resonance in Chemistry. 33: S123-S128. DOI: 10.1002/Mrc.1260331319  0.365
1994 Zweier JL, Kuppusamy P, Thompson-Gorman S, Klunk D, Lutty GA. Measurement and characterization of free radical generation in reoxygenated human endothelial cells American Journal of Physiology - Cell Physiology. 266. PMID 8166233 DOI: 10.1152/Ajpcell.1994.266.3.C700  0.387
1994 Kuppusamy P, Chzhan M, Vij K, Shteynbuk M, Lefer DJ, Giannella E, Zweier JL. Three-dimensional spectral-spatial EPR imaging of free radicals in the heart: a technique for imaging tissue metabolism and oxygenation. Proceedings of the National Academy of Sciences of the United States of America. 91: 3388-92. PMID 8159757 DOI: 10.1073/Pnas.91.8.3388  0.356
1994 Sanders SP, Harrison SJ, Kuppusamy P, Sylvester JT, Zweier JL. A comparative study of EPR spin trapping and cytochrome c reduction techniques for the measurement of superoxide anions Free Radical Biology and Medicine. 16: 753-761. PMID 8070678 DOI: 10.1016/0891-5849(94)90190-2  0.364
1994 Chen K, Ng CE, Zweier JL, Kuppusamy P, Glickson JD, Swartz HM. Measurement of the intracellular concentration of oxygen in a cell perfusion system. Magnetic Resonance in Medicine. 31: 668-72. PMID 8057819 DOI: 10.1002/Mrm.1910310613  0.324
1994 Zweier JL, Broderick R, Kuppusamy P, Thompson-Gorman S, Lutty GA. Determination of the mechanism of free radical generation in human aortic endothelial cells exposed to anoxia and reoxygenation Journal of Biological Chemistry. 269: 24156-24162. PMID 7929072 DOI: 10.13016/M2Xs5Jh7K  0.388
1994 Zweier JL, Chzhan M, Ewert U, Schneider G, Kuppusamy P. Development of a Highly Sensitive Probe for Measuring Oxygen in Biological Tissues Journal of Magnetic Resonance, Series B. 105: 52-57. PMID 7921671 DOI: 10.1006/Jmrb.1994.1099  0.353
1994 Zweier JL, Kuppusamy P. In vivo EPR spectroscopy of free radicals in the heart Environmental Health Perspectives. 102: 45-51. PMID 7705304 DOI: 10.1289/Ehp.94102S1045  0.369
1993 Shandelya SML, Kuppusamy P, Weisfeldt ML, Zweier JL. Evaluation of the role of polymorphonuclear leukocytes on contractile function in myocardial reperfusion injury: Evidence for plasma-mediated leukocyte activation Circulation. 87: 536-546. PMID 8381059 DOI: 10.1161/01.Cir.87.2.536  0.335
1993 Sanders SP, Zweier JL, Kuppusamy P, Harrison SJ, Bessert DJP, Gabrielson EW, Sylvester JT. Hyperoxic sheep pulmonary microvascular endothelial cells generate free radicals via mitochondrial electron transport Journal of Clinical Investigation. 91: 46-52. PMID 8380815 DOI: 10.1172/Jci116198  0.383
1993 Shandelya SML, Kuppusamy P, Herskowitz A, Weisfeldt ML, Zweier JL. Soluble complement receptor type 1 inhibits the complement pathway and prevents contractile failure in the postischemic heart: Evidence that complement activation is required for neutrophil-mediated reperfusion injury Circulation. 88: 2812-2826. PMID 8252695 DOI: 10.1161/01.Cir.88.6.2812  0.411
1993 Li Y, Kuppusamy P, Zweier J, Trush M. Generation of reactive oxygen from the copper-mediated oxidation of the benzene metabolite, 1,4-hydroquinone: Role in DNA damage Free Radical Biology and Medicine. 15: 540. DOI: 10.1016/0891-5849(93)90447-3  0.337
1993 Li Y, Kuppusamy P, Zweier J, Trush M. Chemical mechanism and biological effects of the SOD-accelerated oxidation of 1,4-hydroquinone Free Radical Biology and Medicine. 15: 475. DOI: 10.1016/0891-5849(93)90203-7  0.326
1992 Ambrosio G, Zweier JL, Flaherty JT. The relationship between oxygen radical generation and impairment of myocardial energy metabolism following post-ischemic reperfusion. Journal of Molecular and Cellular Cardiology. 23: 1359-74. PMID 1811055 DOI: 10.1016/0022-2828(91)90183-M  0.407
1992 Povey AC, Wilson VL, Zweier JL, Kuppusamy P, O'Neill IK, Harris CC. Detection by 32P-postlabelling of DNA adducts induced by free radicals and unsaturated aldehydes formed during the aerobic decomposition of fecapentaene-12. Carcinogenesis. 13: 395-401. PMID 1547529 DOI: 10.1093/Carcin/13.3.395  0.343
1992 Grill HP, Zweier JL, Kuppusamy P, Weisfeldt ML, Flaherty JT. Direct measurement of myocardial free radical generation in an in vivo model: Effects of postischemic reperfusion and treatment with human recombinant superoxide dismutase Journal of the American College of Cardiology. 20: 1604-1611. PMID 1333498 DOI: 10.1016/0735-1097(92)90457-X  0.382
1991 Guyton KZ, Bhan P, Kuppusamy P, Zweier JL, Trush MA, Kensler TW. Free radical-derived quinone methide mediates skin tumor promotion by butylated hydroxytoluene hydroperoxide: Expanded role for electrophiles in multistage carcinogenesis Proceedings of the National Academy of Sciences of the United States of America. 88: 946-950. PMID 1846971 DOI: 10.1073/Pnas.88.3.946  0.306
1991 Zweier JL, Thompson-Gorman S, Kuppusamy P. Measurement of oxygen concentrations in the intact beating heart using electron paramagnetic resonance spectroscopy: A technique for measuring oxygen concentrations in situ Journal of Bioenergetics and Biomembranes. 23: 855-871. PMID 1663949 DOI: 10.1007/Bf00786005  0.361
1991 Corretti MC, Koretsune Y, Kusuoka H, Chacko VP, Zweier JL, Marban E. Glycolytic inhibition and calcium overload as consequences of exogenously generated free radicals in rabbit hearts. The Journal of Clinical Investigation. 88: 1014-25. PMID 1653271 DOI: 10.1172/Jci115361  0.353
1990 Maupoil-David V, Rochette L, Zweier JL. Determination by electron paramagnetic resonance (EPR) spectroscopy of superoxide and hydroxyl free radical scavenging effects of sulfhydryl-containing substances Journal of Molecular and Cellular Cardiology. 22: S49. DOI: 10.1016/0022-2828(90)91676-X  0.333
1989 Weisfeldt ML, Zweier J, Ambrosio G, Becker LC, Flaherty JT. Evidence that free radicals result in reperfusion injury in heart muscle. Basic Life Sciences. 49: 911-9. PMID 2855014 DOI: 10.1007/978-1-4684-5568-7_149  0.366
1989 Zweier JL, Duke SS, Kuppusamy P, Sylvester JT, Gabrielson EW. Electron paramagnetic resonance evidence that cellular oxygen toxicity is caused by the generation of superoxide and hydroxyl free radicals Febs Letters. 252: 12-16. PMID 2547649 DOI: 10.1016/0014-5793(89)80881-6  0.405
1989 Taffe BG, Zweier JL, Pannell LK, Kensler TW. Generation of reactive intermediates from the tumor promoter butylated hydroxytoluene hydroperoxide in isolated murine keratinocytes or by hematin. Carcinogenesis. 10: 1261-8. PMID 2472232 DOI: 10.1093/Carcin/10.7.1261  0.341
1988 Zweier JL, Rayburn BK, Flaherty JT, Weisfeldt ML. Recombinant superoxide dismutase reduces oxygen free radical concentrations in reperfused myocardium. The Journal of Clinical Investigation. 80: 1728-34. PMID 3680525 DOI: 10.1172/Jci113264  0.386
1988 Zweier JL, Kuppusamy P. Electron paramagnetic resonance measurements of free radicals in the intact beating heart: A technique for detection and characterization of free radicals in whole biological tissues Proceedings of the National Academy of Sciences of the United States of America. 85: 5703-5707. PMID 2840672 DOI: 10.1073/Pnas.85.15.5703  0.372
1988 Zweier JL, Kuppusamy P, Lutty GA. Measurement of endothelial cell free radical generation: Evidence for a central mechanism of free radical injury in postischemic tissues Proceedings of the National Academy of Sciences of the United States of America. 85: 4046-4050. PMID 2836868 DOI: 10.1073/Pnas.85.11.4046  0.4
1987 Zweier JL, Flaherty JT, Weisfeldt ML. Direct measurement of free radical generation following reperfusion of ischemic myocardium. Proceedings of the National Academy of Sciences of the United States of America. 84: 1404-7. PMID 3029779 DOI: 10.1016/S0022-2828(86)80267-X  0.364
1987 Ambrosio G, Zweier JL, Jacobus WE, Weisfeldt ML, Flaherty JT. Improvement of postischemic myocardial function and metabolism induced by administration of deferoxamine at the time of reflow: the role of iron in the pathogenesis of reperfusion injury. Circulation. 76: 906-15. PMID 2820615 DOI: 10.1161/01.Cir.76.4.906  0.36
1987 WILLIAMS R, ZWEIER J, WEISFELDT M, FLAHERTY J. Effects of deferoxamine (DEF) on ischemic and reperfusion free radical concentrations Journal of Molecular and Cellular Cardiology. 19: S76-S76. DOI: 10.1016/S0022-2828(87)80852-0  0.323
1986 Hilton BD, Misra R, Zweier JL. Magnetic resonance studies of fredericamycin A: Evidence for O2-dependent free-radical formation Biochemistry. 25: 5533-5539. PMID 3022794 DOI: 10.1021/Bi00367A028  0.353
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