Joseph T. Coyle - Publications

Affiliations: 
Harvard Medical School, Boston, MA, United States 
Area:
glutamate

305 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Balu DT, Pantazopoulos H, Huang CCY, Muszynski K, Harvey TL, Uno Y, Rorabaugh JM, Galloway CR, Botz-Zapp C, Berretta S, Weinshenker D, Coyle JT. Neurotoxic astrocytes express the d-serine synthesizing enzyme, serine racemase, in Alzheimer's disease. Neurobiology of Disease. 104511. PMID 31212068 DOI: 10.1016/j.nbd.2019.104511  0.6
2019 Mothet JP, Billard JM, Pollegioni L, Coyle JT, Sweedler JV. Investigating brain d-serine: advocacy for good practices. Acta Physiologica (Oxford, England). e13257. PMID 30650253 DOI: 10.1111/apha.13257  0.32
2018 Konopaske GT, Balu DT, Presti KT, Chan G, Benes FM, Coyle JT. Dysbindin-1 contributes to prefrontal cortical dendritic arbor pathology in schizophrenia. Schizophrenia Research. PMID 29759351 DOI: 10.1016/j.schres.2018.04.042  0.6
2018 Pasternak GW, Coyle JT, Enna SJ. Preface. Advances in Pharmacology (San Diego, Calif.). 82: xv-xx. PMID 29413530 DOI: 10.1016/S1054-3589(18)30008-5  1
2018 Coyle JT, Balu DT. The Role of Serine Racemase in the Pathophysiology of Brain Disorders. Advances in Pharmacology (San Diego, Calif.). 82: 35-56. PMID 29413527 DOI: 10.1016/bs.apha.2017.10.002  0.6
2018 Li S, Uno Y, Rudolph U, Cobb J, Liu J, Anderson T, Levy D, Balu DT, Coyle JT. Astrocytes in Primary Cultures Express Serine Racemase, Synthesize D-Serine and Acquire A1 Reactive Astrocyte Features. Biochemical Pharmacology. PMID 29305854 DOI: 10.1016/j.bcp.2017.12.023  0.6
2017 Balu DT, Coyle JT. Altered CREB Binding to Activity-Dependent Genes in Serine Racemase Deficient Mice, a Mouse Model of Schizophrenia. Acs Chemical Neuroscience. PMID 29172439 DOI: 10.1021/acschemneuro.7b00404  0.6
2017 Puhl MD, Desai RI, Takagi S, Presti KT, Doyle MR, Donahue RJ, Landino SM, Bergman J, Carlezon WA, Coyle JT. N-Methyl-d-aspartate receptor co-agonist availability affects behavioral and neurochemical responses to cocaine: insights into comorbid schizophrenia and substance abuse. Addiction Biology. PMID 29168271 DOI: 10.1111/adb.12577  1
2017 Balu DT, Presti KT, Huang CCY, Muszynski K, Radzishevsky I, Wolosker H, Guffanti G, Ressler KJ, Coyle JT. Serine Racemase and D-serine in the Amygdala Are Dynamically Involved in Fear Learning. Biological Psychiatry. PMID 29025687 DOI: 10.1016/j.biopsych.2017.08.012  0.6
2017 Wolosker H, Balu DT, Coyle JT. Astroglial Versus Neuronal D-Serine: Check Your Controls! Trends in Neurosciences. PMID 28756007 DOI: 10.1016/j.tins.2017.06.010  0.6
2017 Perez EJ, Tapanes SA, Loris ZB, Balu DT, Sick TJ, Coyle JT, Liebl DJ. Enhanced astrocytic d-serine underlies synaptic damage after traumatic brain injury. The Journal of Clinical Investigation. PMID 28714867 DOI: 10.1172/JCI92300  0.6
2016 Wolosker H, Balu DT, Coyle JT. The Rise and Fall of the d-Serine-Mediated Gliotransmission Hypothesis. Trends in Neurosciences. PMID 27742076 DOI: 10.1016/j.tins.2016.09.007  0.6
2016 Basu AC, Puhl MD, Coyle JT. Endogenous co-agonists of the NMDA receptor modulate contextual fear in trace conditioning. Neurobiology of Learning and Memory. PMID 27633914 DOI: 10.1016/j.nlm.2016.09.006  1
2016 Coyle JT, Balu DT, Puhl MD, Konopaske GT. History of the Concept of Disconnectivity in Schizophrenia. Harvard Review of Psychiatry. 24: 80-6. PMID 26954593 DOI: 10.1097/HRP.0000000000000102  1
2016 Balu DT, Li Y, Takagi S, Presti KT, Ramikie TS, Rook JM, Jones CK, Lindsley CW, Conn PJ, Bolshakov VY, Coyle JT. An mGlu5 Positive Allosteric Modulator Rescues the Neuroplasticity Deficits in a Genetic Model of NMDA Receptor Hypofunction in Schizophrenia. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 26741285 DOI: 10.1038/npp.2016.2  0.6
2015 Ishiwata S, Balu DT, Umino A, Coyle JT, Nishikawa T. [JSNP Excellent Presentation Award for CINP2014]. Nihon Shinkei Seishin Yakurigaku Zasshi = Japanese Journal of Psychopharmacology. 35: 53-4. PMID 26027070  0.6
2015 Konopaske GT, Coyle JT. Possible compensatory mechanisms for glutamatergic disconnection found in the auditory cortex in schizophrenia. Biological Psychiatry. 77: 923-4. PMID 25959563 DOI: 10.1016/j.biopsych.2015.03.031  1
2015 Puhl MD, Berg AR, Bechtholt AJ, Coyle JT. Availability of N-Methyl-d-Aspartate Receptor Coagonists Affects Cocaine-Induced Conditioned Place Preference and Locomotor Sensitization: Implications for Comorbid Schizophrenia and Substance Abuse. The Journal of Pharmacology and Experimental Therapeutics. 353: 465-70. PMID 25788713 DOI: 10.1124/jpet.115.223099  1
2015 Ishiwata S, Umino A, Balu DT, Coyle JT, Nishikawa T. Neuronal serine racemase regulates extracellular D-serine levels in the adult mouse hippocampus. Journal of Neural Transmission (Vienna, Austria : 1996). PMID 25782690 DOI: 10.1007/s00702-015-1388-2  1
2015 Konopaske GT, Subburaju S, Coyle JT, Benes FM. Altered prefrontal cortical MARCKS and PPP1R9A mRNA expression in schizophrenia and bipolar disorder. Schizophrenia Research. 164: 100-8. PMID 25757715 DOI: 10.1016/j.schres.2015.02.005  1
2015 Takagi S, Balu DT, Coyle JT. Subchronic pharmacological and chronic genetic NMDA receptor hypofunction differentially regulate the Akt signaling pathway and Arc expression in juvenile and adult mice. Schizophrenia Research. 162: 216-21. PMID 25592804 DOI: 10.1016/j.schres.2014.12.034  1
2015 Balu DT, Coyle JT. The NMDA receptor 'glycine modulatory site' in schizophrenia: D-serine, glycine, and beyond. Current Opinion in Pharmacology. 20: 109-15. PMID 25540902 DOI: 10.1016/j.coph.2014.12.004  1
2015 Zhang S, Wang S, Puhl MD, Jiang X, Hyrc KL, Laciny E, Wallendorf MJ, Pappan KL, Coyle JT, Wice BM. Global biochemical profiling identifies β-hydroxypyruvate as a potential mediator of type 2 diabetes in mice and humans. Diabetes. 64: 1383-94. PMID 25368100 DOI: 10.2337/db14-1188  1
2014 Puhl MD, Mintzopoulos D, Jensen JE, Gillis TE, Konopaske GT, Kaufman MJ, Coyle JT. In vivo magnetic resonance studies reveal neuroanatomical and neurochemical abnormalities in the serine racemase knockout mouse model of schizophrenia. Neurobiology of Disease. 73: 269-274. PMID 25461193 DOI: 10.1016/j.nbd.2014.10.009  1
2014 Konopaske GT, Lange N, Coyle JT, Benes FM. Prefrontal cortical dendritic spine pathology in schizophrenia and bipolar disorder. Jama Psychiatry. 71: 1323-31. PMID 25271938 DOI: 10.1001/jamapsychiatry.2014.1582  1
2014 Balu DT, Coyle JT. Chronic D-serine reverses arc expression and partially rescues dendritic abnormalities in a mouse model of NMDA receptor hypofunction. Neurochemistry International. 75: 76-8. PMID 24915645 DOI: 10.1016/j.neuint.2014.05.015  1
2014 Balu DT, Takagi S, Puhl MD, Benneyworth MA, Coyle JT. D-serine and serine racemase are localized to neurons in the adult mouse and human forebrain. Cellular and Molecular Neurobiology. 34: 419-35. PMID 24436034 DOI: 10.1007/s10571-014-0027-z  1
2014 Santini MA, Balu DT, Puhl MD, Hill-Smith TE, Berg AR, Lucki I, Mikkelsen JD, Coyle JT. D-serine deficiency attenuates the behavioral and cellular effects induced by the hallucinogenic 5-HT(2A) receptor agonist DOI. Behavioural Brain Research. 259: 242-6. PMID 24269270 DOI: 10.1016/j.bbr.2013.11.022  1
2014 Konopaske GT, Coyle JT. Schizophrenia Neurobiology of Brain Disorders: Biological Basis of Neurological and Psychiatric Disorders. 639-654. DOI: 10.1016/B978-0-12-398270-4.00039-2  1
2014 Coyle JT. Introduction Neurobiology of Brain Disorders: Biological Basis of Neurological and Psychiatric Disorders. 523-524. DOI: 10.1016/B978-0-12-398270-4.00031-8  1
2014 Coyle JT. Farewell Jama Psychiatry. 71: 1321-1322.  1
2013 Coyle JT, Ongur D. Relapse in alcohol use disorder--reply. Jama Psychiatry. 70: 1248. PMID 24196497 DOI: 10.1001/jamapsychiatry.2013.2879  1
2013 Coyle JT. Brain structural alterations induced by fetal exposure to cocaine persist into adolescence and affect behavior. Jama Psychiatry. 70: 1113-4. PMID 23986322 DOI: 10.1001/jamapsychiatry.2013.1949  1
2013 Balu DT, Li Y, Puhl MD, Benneyworth MA, Basu AC, Takagi S, Bolshakov VY, Coyle JT. Multiple risk pathways for schizophrenia converge in serine racemase knockout mice, a mouse model of NMDA receptor hypofunction. Proceedings of the National Academy of Sciences of the United States of America. 110: E2400-9. PMID 23729812 DOI: 10.1073/pnas.1304308110  1
2013 Coyle JT. Nitric oxide and symptom reduction in schizophrenia. Jama Psychiatry. 70: 664-5. PMID 23699799 DOI: 10.1001/jamapsychiatry.2013.210  1
2013 Konopaske GT, Bolo NR, Basu AC, Renshaw PF, Coyle JT. Time-dependent effects of haloperidol on glutamine and GABA homeostasis and astrocyte activity in the rat brain. Psychopharmacology. 230: 57-67. PMID 23660600 DOI: 10.1007/s00213-013-3136-3  1
2013 Li Y, Sacchi S, Pollegioni L, Basu AC, Coyle JT, Bolshakov VY. Identity of endogenous NMDAR glycine site agonist in amygdala is determined by synaptic activity level. Nature Communications. 4: 1760. PMID 23612301 DOI: 10.1038/ncomms2779  1
2013 Coyle JT. Much more than a name change. Jama Psychiatry. 70: 8. PMID 23303609 DOI: 10.1001/jamapsychiatry.2013.794  1
2012 Coyle JT. Changing to JAMA Psychiatry. Archives of General Psychiatry. 69: 661. PMID 23754033 DOI: 10.1001/archgenpsychiatry.2012.785  1
2012 Coyle JT, Basu A, Benneyworth M, Balu D, Konopaske G. Glutamatergic synaptic dysregulation in schizophrenia: therapeutic implications. Handbook of Experimental Pharmacology. 267-95. PMID 23027419 DOI: 10.1007/978-3-642-25758-2_10  1
2012 Coyle JT. NMDA receptor and schizophrenia: a brief history. Schizophrenia Bulletin. 38: 920-6. PMID 22987850 DOI: 10.1093/schbul/sbs076  1
2012 Benneyworth MA, Coyle JT. Altered acquisition and extinction of amphetamine-paired context conditioning in genetic mouse models of altered NMDA receptor function. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 2496-504. PMID 22763616 DOI: 10.1038/npp.2012.108  1
2012 Coyle JT. Changes in JAMA and the Archives of General Psychiatry: what they mean for readers and authors. Archives of General Psychiatry. 69: 447-8. PMID 22566577 DOI: 10.1001/archgenpsychiatry.2012.398  1
2012 Balu DT, Coyle JT. Neuronal D-serine regulates dendritic architecture in the somatosensory cortex. Neuroscience Letters. 517: 77-81. PMID 22521586 DOI: 10.1016/j.neulet.2012.04.020  1
2012 Benneyworth MA, Li Y, Basu AC, Bolshakov VY, Coyle JT. Cell selective conditional null mutations of serine racemase demonstrate a predominate localization in cortical glutamatergic neurons. Cellular and Molecular Neurobiology. 32: 613-24. PMID 22362148 DOI: 10.1007/s10571-012-9808-4  1
2012 Bergeron R, Coyle JT. NAAG, NMDA receptor and psychosis. Current Medicinal Chemistry. 19: 1360-4. PMID 22304714 DOI: 10.2174/092986712799462685  1
2012 Chen Y, Norton DJ, McBain R, Gold J, Frazier JA, Coyle JT. Enhanced local processing of dynamic visual information in autism: evidence from speed discrimination. Neuropsychologia. 50: 733-9. PMID 22261399 DOI: 10.1016/j.neuropsychologia.2012.01.007  1
2012 Schaevitz LR, Picker JD, Rana J, Kolodny NH, Shane B, Berger-Sweeney JE, Coyle JT. Glutamate carboxypeptidase II and folate deficiencies result in reciprocal protection against cognitive and social deficits in mice: implications for neurodevelopmental disorders. Developmental Neurobiology. 72: 891-905. PMID 22076974 DOI: 10.1002/dneu.21000  1
2012 Balu DT, Basu AC, Corradi JP, Cacace AM, Coyle JT. The NMDA receptor co-agonists, D-serine and glycine, regulate neuronal dendritic architecture in the somatosensory cortex. Neurobiology of Disease. 45: 671-82. PMID 22024716 DOI: 10.1016/j.nbd.2011.10.006  1
2012 Barrett JE, Coyle JT. Section summary and perspectives: Neurodevelopmental disorders and regulation of epigenetic changes Translational Neuroscience: Applications in Psychiatry, Neurology, and Neurodevelopmental Disorders. 334-338. DOI: 10.1017/CBO9780511980053.020  1
2012 Barrett JE, Coyle JT. Section summary and perspectives: Translational medicine in neurology Translational Neuroscience: Applications in Psychiatry, Neurology, and Neurodevelopmental Disorders. 253-260. DOI: 10.1017/CBO9780511980053.015  1
2012 Williams M, Coyle JT. Historical perspectives on the discovery and development of drugs to treat neurological disorders Translational Neuroscience: Applications in Psychiatry, Neurology, and Neurodevelopmental Disorders. 129-148. DOI: 10.1017/CBO9780511980053.008  1
2012 Coyle JT. Section summary and perspectives: Translational medicine in psychiatry Translational Neuroscience: Applications in Psychiatry, Neurology, and Neurodevelopmental Disorders. 118-128. DOI: 10.1017/CBO9780511980053.007  1
2012 Barrett JE, Williams M, Coyle JT. Translational neuroscience: Applications in psychiatry, neurology, and neurodevelopmental disorders Translational Neuroscience: Applications in Psychiatry, Neurology, and Neurodevelopmental Disorders. 1-366. DOI: 10.1017/CBO9780511980053  1
2012 Coyle JT, Konopaske GT. The Neurochemistry of Schizophrenia Basic Neurochemistry. 1000-1011. DOI: 10.1016/B978-0-12-374947-5.00058-4  1
2011 Sullivan SJ, Esguerra M, Wickham RJ, Romero GE, Coyle JT, Miller RF. Serine racemase deletion abolishes light-evoked NMDA receptor currents in retinal ganglion cells. The Journal of Physiology. 589: 5997-6006. PMID 22041185 DOI: 10.1113/jphysiol.2011.217059  1
2011 Balu DT, Coyle JT. Glutamate receptor composition of the post-synaptic density is altered in genetic mouse models of NMDA receptor hypo- and hyperfunction. Brain Research. 1392: 1-7. PMID 21443867 DOI: 10.1016/j.brainres.2011.03.051  1
2011 Benneyworth MA, Roseman AS, Basu AC, Coyle JT. Failure of NMDA receptor hypofunction to induce a pathological reduction in PV-positive GABAergic cell markers. Neuroscience Letters. 488: 267-71. PMID 21094213 DOI: 10.1016/j.neulet.2010.11.043  1
2011 DeVito LM, Balu DT, Kanter BR, Lykken C, Basu AC, Coyle JT, Eichenbaum H. Serine racemase deletion disrupts memory for order and alters cortical dendritic morphology. Genes, Brain, and Behavior. 10: 210-22. PMID 21029376 DOI: 10.1111/j.1601-183X.2010.00656.x  1
2011 Balu DT, Coyle JT. Neuroplasticity signaling pathways linked to the pathophysiology of schizophrenia. Neuroscience and Biobehavioral Reviews. 35: 848-70. PMID 20951727 DOI: 10.1016/j.neubiorev.2010.10.005  1
2011 Benneyworth MA, Basu AC, Coyle JT. Discordant behavioral effects of psychotomimetic drugs in mice with altered NMDA receptor function. Psychopharmacology. 213: 143-53. PMID 20865248 DOI: 10.1007/s00213-010-2023-4  1
2011 Coyle JT. Online first Archives of General Psychiatry. 68: 339. DOI: 10.1001/archgenpsychiatry.2011.31  1
2010 Coyle JT, Balu D, Benneyworth M, Basu A, Roseman A. Beyond the dopamine receptor: novel therapeutic targets for treating schizophrenia. Dialogues in Clinical Neuroscience. 12: 359-82. PMID 20954431  1
2010 Mustafa AK, Ahmad AS, Zeynalov E, Gazi SK, Sikka G, Ehmsen JT, Barrow RK, Coyle JT, Snyder SH, Doré S. Serine racemase deletion protects against cerebral ischemia and excitotoxicity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 1413-6. PMID 20107067 DOI: 10.1523/JNEUROSCI.4297-09.2010  1
2010 Basu AC, Tsai GE, Ma CL, Ehmsen JT, Mustafa AK, Han L, Jiang ZI, Benneyworth MA, Froimowitz MP, Lange N, Snyder SH, Bergeron R, Coyle JT. Targeted disruption of serine racemase affects glutamatergic neurotransmission and behavior (Molecular Psychiatry (2009) 14 (719-727) DOI: 10.1038/mp.2008.130) Molecular Psychiatry. 15: 1122. DOI: 10.1038/mp.2010.84  1
2009 Reed BT, Sullivan SJ, Tsai G, Coyle JT, Esguerra M, Miller RF. The glycine transporter GlyT1 controls N-methyl-D-aspartic acid receptor coagonist occupancy in the mouse retina. The European Journal of Neuroscience. 30: 2308-17. PMID 20092573 DOI: 10.1111/j.1460-9568.2009.07020.x  1
2009 Ghose S, Chin R, Gallegos A, Roberts R, Coyle J, Tamminga C. Localization of NAAG-related gene expression deficits to the anterior hippocampus in schizophrenia Schizophrenia Research. 111: 131-137. PMID 19403271 DOI: 10.1016/j.schres.2009.03.038  1
2009 Duggan PS, Siegel AW, Blass DM, Bok H, Coyle JT, Faden R, Finkel J, Gearhart JD, Greely HT, Hillis A, Hoke A, Johnson R, Johnston M, Kahn J, Kerr D, et al. Unintended changes in cognition, mood, and behavior arising from cell-based interventions for neurological conditions: ethical challenges. The American Journal of Bioethics : Ajob. 9: 31-6. PMID 19396681 DOI: 10.1080/15265160902788645  1
2009 Han L, Picker JD, Schaevitz LR, Tsai G, Feng J, Jiang Z, Chu HC, Basu AC, Berger-Sweeney J, Coyle JT. Phenotypic characterization of mice heterozygous for a null mutation of glutamate carboxypeptidase II. Synapse (New York, N.Y.). 63: 625-35. PMID 19347959 DOI: 10.1002/syn.20649  1
2009 Coyle JT. MicroRNAs suggest a new mechanism for altered brain gene expression in schizophrenia. Proceedings of the National Academy of Sciences of the United States of America. 106: 2975-6. PMID 19251669 DOI: 10.1073/pnas.0813321106  1
2009 Basu AC, Tsai GE, Ma CL, Ehmsen JT, Mustafa AK, Han L, Jiang ZI, Benneyworth MA, Froimowitz MP, Lange N, Snyder SH, Bergeron R, Coyle JT. Targeted disruption of serine racemase affects glutamatergic neurotransmission and behavior. Molecular Psychiatry. 14: 719-27. PMID 19065142 DOI: 10.1038/mp.2008.130  1
2009 Regenberg A, Mathews DJ, Blass DM, Bok H, Coyle JT, Duggan P, Faden R, Finkel J, Gearhart JD, Hillis A, Hoke A, Johnson R, Johnston M, Kahn J, Kerr D, et al. The role of animal models in evaluating reasonable safety and efficacy for human trials of cell-based interventions for neurologic conditions. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 29: 1-9. PMID 18728679 DOI: 10.1038/jcbfm.2008.98  1
2008 Mathews DJ, Sugarman J, Bok H, Blass DM, Coyle JT, Duggan P, Finkel J, Greely HT, Hillis A, Hoke A, Johnson R, Johnston M, Kahn J, Kerr D, Kurtzberg J, et al. Cell-based interventions for neurologic conditions: ethical challenges for early human trials. Neurology. 71: 288-93. PMID 18463365 DOI: 10.1212/01.wnl.0000316436.13659.80  1
2008 Lisman JE, Coyle JT, Green RW, Javitt DC, Benes FM, Heckers S, Grace AA. Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia. Trends in Neurosciences. 31: 234-42. PMID 18395805 DOI: 10.1016/j.tins.2008.02.005  1
2007 Lawson-Yuen A, Liu D, Han L, Jiang ZI, Tsai GE, Basu AC, Picker J, Feng J, Coyle JT. Ube3a mRNA and protein expression are not decreased in Mecp2R168X mutant mice. Brain Research. 1180: 1-6. PMID 17936729 DOI: 10.1016/j.brainres.2007.08.039  1
2007 Han L, Wong DL, Tsai G, Jiang Z, Coyle JT. Promoter analysis of human glutamate carboxypeptidase II. Brain Research. 1170: 1-12. PMID 17689503 DOI: 10.1016/j.brainres.2007.07.017  1
2007 Coyle JT, Geerts H, Sorra K, Amatniek J. Beyond in vitro data: a review of in vivo evidence regarding the allosteric potentiating effect of galantamine on nicotinic acetylcholine receptors in Alzheimer's neuropathology. Journal of Alzheimer's Disease : Jad. 11: 491-507. PMID 17656829  1
2007 Coyle JT. What can a clock mutation in mice tell us about bipolar disorder? Proceedings of the National Academy of Sciences of the United States of America. 104: 6097-8. PMID 17404212 DOI: 10.1073/pnas.0701491104  1
2007 Bergeron R, Imamura Y, Frangioni JV, Greene RW, Coyle JT. Endogenous N-acetylaspartylglutamate reduced NMDA receptor-dependent current neurotransmission in the CA1 area of the hippocampus. Journal of Neurochemistry. 100: 346-57. PMID 17241157 DOI: 10.1111/j.1471-4159.2006.04253.x  1
2007 Siekmeier PJ, Hasselmo ME, Howard MW, Coyle J. Modeling of context-dependent retrieval in hippocampal region CA1: implications for cognitive function in schizophrenia. Schizophrenia Research. 89: 177-90. PMID 17055702 DOI: 10.1016/j.schres.2006.08.007  1
2007 Frye MA, Tsai GE, Huggins T, Coyle JT, Post RM. Low cerebrospinal fluid glutamate and glycine in refractory affective disorder. Biological Psychiatry. 61: 162-6. PMID 16735030 DOI: 10.1016/j.biopsych.2006.01.024  1
2007 Ross CA, Margolis RL, Reading SAJ, Pletnikov M, Coyle JT. Neurobiology of schizophrenia | Neurobiologia schizofrenii Wiadomosci Psychiatryczne. 10: 195-215.  1
2006 Coyle JT. Substance use disorders and Schizophrenia: a question of shared glutamatergic mechanisms. Neurotoxicity Research. 10: 221-33. PMID 17197372 DOI: 10.1007/BF03033359  1
2006 Ross CA, Margolis RL, Reading SA, Pletnikov M, Coyle JT. Neurobiology of schizophrenia. Neuron. 52: 139-53. PMID 17015232 DOI: 10.1016/j.neuron.2006.09.015  1
2006 Coyle JT. A brief overview of N-acetylaspartate and N-acetylaspartylglutamate. Advances in Experimental Medicine and Biology. 576: 1-6; discussion 361-. PMID 16802701 DOI: 10.1007/0-387-30172-0_1  1
2006 Coyle JT. Glutamate and schizophrenia: beyond the dopamine hypothesis. Cellular and Molecular Neurobiology. 26: 365-84. PMID 16773445 DOI: 10.1007/s10571-006-9062-8  1
2006 Coyle JT. Glial metabolites of tryptophan and excitotoxicity: coming unglued. Experimental Neurology. 197: 4-7. PMID 16300760 DOI: 10.1016/j.expneurol.2005.10.021  1
2006 Coyle JT, Heckers S. Update on the conflict of interest policy for the Archives Archives of General Psychiatry. 63: 1178.  1
2005 Picker JD, Coyle JT. Do maternal folate and homocysteine levels play a role in neurodevelopmental processes that increase risk for schizophrenia? Harvard Review of Psychiatry. 13: 197-205. PMID 16126606 DOI: 10.1080/10673220500243372  1
2005 Greene M, Schill K, Takahashi S, Bateman-House A, Beauchamp T, Bok H, Cheney D, Coyle J, Deacon T, Dennett D, Donovan P, Flanagan O, Goldman S, Greely H, Martin L, et al. Ethics: Moral issues of human-non-human primate neural grafting. Science (New York, N.Y.). 309: 385-6. PMID 16020716 DOI: 10.1126/science.1112207  1
2005 Yurgelun-Todd DA, Coyle JT, Gruber SA, Renshaw PF, Silveri MM, Amico E, Cohen B, Goff DC. Functional magnetic resonance imaging studies of schizophrenic patients during word production: effects of D-cycloserine. Psychiatry Research. 138: 23-31. PMID 15708298 DOI: 10.1016/j.pscychresns.2004.11.006  1
2005 Martina M, B-Turcotte ME, Halman S, Tsai G, Tiberi M, Coyle JT, Bergeron R. Reduced glycine transporter type 1 expression leads to major changes in glutamatergic neurotransmission of CA1 hippocampal neurones in mice. The Journal of Physiology. 563: 777-93. PMID 15661817 DOI: 10.1113/jphysiol.2004.080655  1
2005 Bergeron R, Coyle JT, Tsai G, Greene RW. NAAG reduces NMDA receptor current in CA1 hippocampal pyramidal neurons of acute slices and dissociated neurons. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 30: 7-16. PMID 15354184 DOI: 10.1038/sj.npp.1300559  1
2005 Coyle JT. Beginning year 4 Archives of General Psychiatry. 62: 14. DOI: 10.1001/archpsyc.62.1.14  1
2004 Coyle JT. The GABA-glutamate connection in schizophrenia: which is the proximate cause? Biochemical Pharmacology. 68: 1507-14. PMID 15451393 DOI: 10.1016/j.bcp.2004.07.034  1
2004 Goff DC, Bottiglieri T, Arning E, Shih V, Freudenreich O, Evins AE, Henderson DC, Baer L, Coyle J. Folate, homocysteine, and negative symptoms in schizophrenia American Journal of Psychiatry. 161: 1705-1708. PMID 15337665 DOI: 10.1176/appi.ajp.161.9.1705  1
2004 Coyle JT, Tsai G. The NMDA receptor glycine modulatory site: a therapeutic target for improving cognition and reducing negative symptoms in schizophrenia. Psychopharmacology. 174: 32-8. PMID 15205876 DOI: 10.1007/s00213-003-1709-2  1
2004 Tsai G, Ralph-Williams RJ, Martina M, Bergeron R, Berger-Sweeney J, Dunham KS, Jiang Z, Caine SB, Coyle JT. Gene knockout of glycine transporter 1: characterization of the behavioral phenotype. Proceedings of the National Academy of Sciences of the United States of America. 101: 8485-90. PMID 15159536 DOI: 10.1073/pnas.0402662101  1
2004 Coyle JT, Tsai G. NMDA receptor function, neuroplasticity, and the pathophysiology of schizophrenia. International Review of Neurobiology. 59: 491-515. PMID 15006500 DOI: 10.1016/S0074-7742(04)59019-0  1
2004 Javitt DC, Coyle JT. Decoding schizophrenia. Scientific American. 290: 48-55. PMID 14682038  1
2004 Ghose S, Weickert CS, Colvin SM, Coyle JT, Herman MM, Hyde TM, Kleinman JE. Glutamate carboxypeptidase II gene expression in the human frontal and temporal lobe in schizophrenia. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 29: 117-25. PMID 14560319 DOI: 10.1038/sj.npp.1300304  1
2004 Coyle JT. The demise of old certitudes and the birth of novel opportunities in neuropsychopharmacology Current Opinion in Pharmacology. 4: 1-3. DOI: 10.1016/j.coph.2003.12.001  1
2003 Coyle JT, Tsai G, Goff D. Converging evidence of NMDA receptor hypofunction in the pathophysiology of schizophrenia. Annals of the New York Academy of Sciences. 1003: 318-27. PMID 14684455 DOI: 10.1196/annals.1300.020  1
2003 Coyle JT, Pine DS, Charney DS, Lewis L, Nemeroff CB, Carlson GA, Joshi PT, Reiss D, Todd RD, Hellander M. Depression and bipolar support alliance consensus statement on the unmet needs in diagnosis and treatment of mood disorders in children and adolescents. Journal of the American Academy of Child and Adolescent Psychiatry. 42: 1494-503. PMID 14627885 DOI: 10.1097/01.chi.0000091945.28938.8f  1
2003 Tsai G, Dunham KS, Drager U, Grier A, Anderson C, Collura J, Coyle JT. Early embryonic death of glutamate carboxypeptidase II (NAALADase) homozygous mutants. Synapse (New York, N.Y.). 50: 285-92. PMID 14556233 DOI: 10.1002/syn.10263  1
2003 Coyle JT. Use it or lose it--do effortful mental activities protect against dementia? The New England Journal of Medicine. 348: 2489-90. PMID 12815133 DOI: 10.1056/NEJMp030051  1
2003 Coyle JT, Duman RS. Finding the intracellular signaling pathways affected by mood disorder treatments. Neuron. 38: 157-60. PMID 12718851 DOI: 10.1016/S0896-6273(03)00195-8  1
2003 Flores C, Coyle JT. Regulation of glutamate carboxypeptidase II function in corticolimbic regions of rat brain by phencyclidine, haloperidol, and clozapine. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 28: 1227-34. PMID 12700705 DOI: 10.1038/sj.npp.1300129  1
2002 Coyle JT, Tsai G, Goff DC. Ionotropic glutamate receptors as therapeutic targets in schizophrenia. Current Drug Targets. Cns and Neurological Disorders. 1: 183-9. PMID 12769626  1
2002 Coyle JT, Manji HK. Getting balance: drugs for bipolar disorder share target. Nature Medicine. 8: 557-8. PMID 12042799 DOI: 10.1038/nm0602-557  1
2002 Tsai G, Coyle JT. Glutamatergic mechanisms in schizophrenia. Annual Review of Pharmacology and Toxicology. 42: 165-79. PMID 11807169 DOI: 10.1146/annurev.pharmtox.42.082701.160735  1
2002 Frazier JA, Doyle R, Chiu S, Coyle JT. Treating a child with Asperger's disorder and comorbid bipolar disorder. The American Journal of Psychiatry. 159: 13-21. PMID 11772683 DOI: 10.1176/appi.ajp.159.1.13  1
2002 Leski ML, Hassinger LC, Valentine SL, Baer JD, Coyle JT. L-type calcium channels reduce ROS generation in cerebellar granule cells following kainate exposure. Synapse (New York, N.Y.). 43: 30-41. PMID 11746731 DOI: 10.1002/syn.10015  1
2001 Goff DC, Coyle JT. The emerging role of glutamate in the pathophysiology and treatment of schizophrenia. The American Journal of Psychiatry. 158: 1367-77. PMID 11532718 DOI: 10.1176/appi.ajp.158.9.1367  1
2001 Coyle JT. Drug treatment of anxiety disorders in children. The New England Journal of Medicine. 344: 1326-7. PMID 11320394 DOI: 10.1056/NEJM200104263441711  1
2001 Coyle JT. Childhood mood disorders: Unmet needs but important opportunities Biological Psychiatry. 49: 959. DOI: 10.1016/S0006-3223(01)01185-4  1
2001 Williams M, Coyle JT, Shaikh S, Decker MW. Chapter 1: Same brain, new decade: Challenges in CNS drug discovery in the postgenomic, proteomic era Annual Reports in Medicinal Chemistry. 36: 1-10.  1
2000 Greene R, Bergeron R, McCarley R, Coyle JT, Grunze H. Short-term and long-term effects of N-methyl-D-aspartate receptor hypofunction. Archives of General Psychiatry. 57: 1180-1; author reply. PMID 11115333  1
2000 Leski ML, Valentine SL, Baer JD, Coyle JT. Insulin-like growth factor I prevents the development of sensitivity to kainate neurotoxicity in cerebellar granule cells. Journal of Neurochemistry. 75: 1548-56. PMID 10987835 DOI: 10.1046/j.1471-4159.2000.0751548.x  1
2000 Leveque JC, Macías W, Rajadhyaksha A, Carlson RR, Barczak A, Kang S, Li XM, Coyle JT, Huganir RL, Heckers S, Konradi C. Intracellular modulation of NMDA receptor function by antipsychotic drugs. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 4011-20. PMID 10818136  1
2000 Nguyen TV, Brownell AL, Iris Chen YC, Livni E, Coyle JT, Rosen BR, Cavagna F, Jenkins BG. Detection of the effects of dopamine receptor supersensitivity using pharmacological MRI and correlations with PET. Synapse (New York, N.Y.). 36: 57-65. PMID 10700026 DOI: 10.1002/(SICI)1098-2396(200004)36:1<57::AID-SYN6>3.0.CO;2-K  1
2000 Coyle JT. Psychotropic drug use in very young children. Jama. 283: 1059-60. PMID 10697069  1
2000 Price BH, Adams RD, Coyle JT. Neurology and psychiatry: closing the great divide. Neurology. 54: 8-14. PMID 10636118  1
2000 Coyle JT, Schwarcz R. Mind glue: implications of glial cell biology for psychiatry. Archives of General Psychiatry. 57: 90-3. PMID 10632240  1
1999 Tsai GE, Yang P, Chung LC, Tsai IC, Tsai CW, Coyle JT. D-serine added to clozapine for the treatment of schizophrenia. The American Journal of Psychiatry. 156: 1822-5. PMID 10553752  1
1999 Berger UV, Luthi-Carter R, Passani LA, Elkabes S, Black I, Konradi C, Coyle JT. Glutamate carboxypeptidase II is expressed by astrocytes in the adult rat nervous system. The Journal of Comparative Neurology. 415: 52-64. PMID 10540357 DOI: 10.1002/(SICI)1096-9861(19991206)415:1<52::AID-CNE4>3.0.CO;2-K  1
1999 Leski ML, Valentine SL, Coyle JT. L-type voltage-gated calcium channels modulate kainic acid neurotoxicity in cerebellar granule cells. Brain Research. 828: 27-40. PMID 10320722 DOI: 10.1016/S0006-8993(99)01270-6  1
1999 Tsai GE, Falk WE, Gunther J, Coyle JT. Improved cognition in Alzheimer's disease with short-term D-cycloserine treatment. The American Journal of Psychiatry. 156: 467-9. PMID 10080566  1
1999 Goff DC, Tsai G, Levitt J, Amico E, Manoach D, Schoenfeld DA, Hayden DL, McCarley R, Coyle JT. A placebo-controlled trial of D-cycloserine added to conventional neuroleptics in patients with schizophrenia. Archives of General Psychiatry. 56: 21-7. PMID 9892252 DOI: 10.1001/archpsyc.56.1.21  1
1999 Speno HS, Luthi-Carter R, Macias WL, Valentine SL, Joshi AR, Coyle JT. Site-directed mutagenesis of predicted active site residues in glutamate carboxypeptidase II. Molecular Pharmacology. 55: 179-85. PMID 9882712  1
1998 Steingard RJ, Schmidt C, Coyle JT. Basic neuroscience: critical issues for understanding psychiatric disorders. Adolescent Medicine (Philadelphia, Pa.). 9: 205-15, v. PMID 10961230  1
1998 Bergeron R, Meyer TM, Coyle JT, Greene RW. Modulation of N-methyl-D-aspartate receptor function by glycine transport. Proceedings of the National Academy of Sciences of the United States of America. 95: 15730-4. PMID 9861038 DOI: 10.1073/pnas.95.26.15730  1
1998 Tsai G, Yang P, Chung LC, Lange N, Coyle JT. D-serine added to antipsychotics for the treatment of schizophrenia. Biological Psychiatry. 44: 1081-9. PMID 9836012 DOI: 10.1016/S0006-3223(98)00279-0  1
1998 Tsai G, van Kammen DP, Chen S, Kelley ME, Grier A, Coyle JT. Glutamatergic neurotransmission involves structural and clinical deficits of schizophrenia. Biological Psychiatry. 44: 667-74. PMID 9798069 DOI: 10.1016/S0006-3223(98)00151-6  1
1998 Tsai G, Goff DC, Chang RW, Flood J, Baer L, Coyle JT. Markers of glutamatergic neurotransmission and oxidative stress associated with tardive dyskinesia. The American Journal of Psychiatry. 155: 1207-13. PMID 9734544  1
1998 Corsi P, Forloni G, Troia M, Lettini T, Coyle JT. Somatostatin expression in TS16 mouse brain cultures. Journal of Molecular Neuroscience : Mn. 10: 99-111. PMID 9699151 DOI: 10.1007/BF02737121  1
1998 Luthi-Carter R, Barczak AK, Speno H, Coyle JT. Molecular characterization of human brain N-acetylated alpha-linked acidic dipeptidase (NAALADase). The Journal of Pharmacology and Experimental Therapeutics. 286: 1020-5. PMID 9694964  1
1998 Halsted CH, Ling EH, Luthi-Carter R, Villanueva JA, Gardner JM, Coyle JT. Folylpoly-gamma-glutamate carboxypeptidase from pig jejunum. Molecular characterization and relation to glutamate carboxypeptidase II. The Journal of Biological Chemistry. 273: 20417-24. PMID 9685395 DOI: 10.1074/jbc.273.32.20417  1
1998 Schwartz PJ, Coyle JT. Effects of overexpression of the cytoplasmic copper-zinc superoxide dismutase on the survival of neurons in vitro. Synapse (New York, N.Y.). 29: 206-12. PMID 9635890 DOI: 10.1002/(SICI)1098-2396(199807)29:3<206::AID-SYN2>3.0.CO;2-A  1
1998 Passani L, Elkabes S, Coyle JT. Evidence for the presence of N-acetylaspartylglutamate in cultured oligodendrocytes and LPS activated microglia. Brain Research. 794: 143-5. PMID 9630582 DOI: 10.1016/S0006-8993(98)00308-4  1
1998 Luthi-Carter R, Barczak AK, Speno H, Coyle JT. Hydrolysis of the neuropeptide N-acetylaspartylglutamate (NAAG) by cloned human glutamate carboxypeptidase II. Brain Research. 795: 341-8. PMID 9622670 DOI: 10.1016/S0006-8993(98)00244-3  1
1998 Tsai GE, Ragan P, Chang R, Chen S, Linnoila VM, Coyle JT. Increased glutamatergic neurotransmission and oxidative stress after alcohol withdrawal. The American Journal of Psychiatry. 155: 726-32. PMID 9619143  1
1998 Benes F, Coyle JT. Déja vu all over again. Biological Psychiatry. 43: 781-2. PMID 9611666 DOI: 10.1016/S0006-3223(98)00116-4  1
1998 Schwartz PJ, Reaume A, Scott R, Coyle JT. Effects of over- and under-expression of Cu,Zn-superoxide dismutase on the toxicity of glutamate analogs in transgenic mouse striatum. Brain Research. 789: 32-9. PMID 9602043 DOI: 10.1016/S0006-8993(97)01469-8  1
1998 Tsai G, Coyle JT. The role of glutamatergic neurotransmission in the pathophysiology of alcoholism. Annual Review of Medicine. 49: 173-84. PMID 9509257 DOI: 10.1146/annurev.med.49.1.173  1
1998 Luthi-Carter R, Berger UV, Barczak AK, Enna M, Coyle JT. Isolation and expression of a rat brain cDNA encoding glutamate carboxypeptidase II. Proceedings of the National Academy of Sciences of the United States of America. 95: 3215-20. PMID 9501243 DOI: 10.1073/pnas.95.6.3215  1
1997 Passani LA, Vonsattel JP, Coyle JT. Distribution of N-acetylaspartylglutamate immunoreactivity in human brain and its alteration in neurodegenerative disease. Brain Research. 772: 9-22. PMID 9406950 DOI: 10.1016/S0006-8993(97)00784-1  1
1997 Orlando LR, Luthi-Carter R, Standaert DG, Coyle JT, Penney JB, Young AB. N-acetylaspartylglutamate (NAAG) protects against rat striatal quinolinic acid lesions in vivo. Neuroscience Letters. 236: 91-4. PMID 9404819 DOI: 10.1016/S0304-3940(97)00769-6  1
1997 Coyle JT, Mallet J. Disease, transplantation and regeneration. Current Opinion in Neurobiology. 7: 663-5. PMID 9384555 DOI: 10.1016/S0959-4388(97)80086-4  1
1997 Passani LA, Vonsattel JP, Carter RE, Coyle JT. N-acetylaspartylglutamate, N-acetylaspartate, and N-acetylated alpha-linked acidic dipeptidase in human brain and their alterations in Huntington and Alzheimer's diseases. Molecular and Chemical Neuropathology / Sponsored by the International Society For Neurochemistry and the World Federation of Neurology and Research Groups On Neurochemistry and Cerebrospinal Fluid. 31: 97-118. PMID 9376025 DOI: 10.1007/BF02815236  1
1997 Coyle JT. The nagging question of the function of N-acetylaspartylglutamate. Neurobiology of Disease. 4: 231-8. PMID 9361299 DOI: 10.1006/nbdi.1997.0153  1
1996 Coyle JT. The glutamatergic dysfunction hypothesis for schizophrenia. Harvard Review of Psychiatry. 3: 241-53. PMID 9384954  1
1996 Goff DC, Tsai G, Manoach DS, Flood J, Darby DG, Coyle JT. D-cycloserine added to clozapine for patients with schizophrenia. The American Journal of Psychiatry. 153: 1628-30. PMID 8942463  1
1996 Simonian NA, Getz RL, Leveque JC, Konradi C, Coyle JT. Kainic acid induces apoptosis in neurons. Neuroscience. 75: 1047-55. PMID 8938740 DOI: 10.1016/0306-4522(96)00326-0  1
1996 Simonian NA, Getz RL, Leveque JC, Konradi C, Coyle JT. Kainate induces apoptosis in neurons. Neuroscience. 74: 675-83. PMID 8884764 DOI: 10.1016/0306-4522(96)00141-8  1
1996 Ranen NG, Peyser CE, Coyle JT, Bylsma FW, Sherr M, Day L, Folstein MF, Brandt J, Ross CA, Folstein SE. A controlled trial of idebenone in Huntington's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 11: 549-54. PMID 8866496 DOI: 10.1002/mds.870110510  1
1996 Simonian NA, Coyle JT. Oxidative stress in neurodegenerative diseases. Annual Review of Pharmacology and Toxicology. 36: 83-106. PMID 8725383 DOI: 10.1146/annurev.pa.36.040196.000503  1
1996 Didier M, Bursztajn S, Adamec E, Passani L, Nixon RA, Coyle JT, Wei JY, Berman SA. DNA strand breaks induced by sustained glutamate excitotoxicity in primary neuronal cultures. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 2238-50. PMID 8601804  1
1996 Carter RE, Feldman AR, Coyle JT. Prostate-specific membrane antigen is a hydrolase with substrate and pharmacologic characteristics of a neuropeptidase. Proceedings of the National Academy of Sciences of the United States of America. 93: 749-53. PMID 8570628 DOI: 10.1073/pnas.93.2.749  1
1995 Coyle JT. The neuroscience perspective and the changing role of the psychiatrist : the challenge for psychiatric educators. Academic Psychiatry : the Journal of the American Association of Directors of Psychiatric Residency Training and the Association For Academic Psychiatry. 19: 202-12. PMID 24435610 DOI: 10.1007/BF03341546  1
1995 Guimaraes AR, Schwartz P, Prakash MR, Carr CA, Berger UV, Jenkins BG, Coyle JT, González RG. Quantitative in vivo 1H nuclear magnetic resonance spectroscopic imaging of neuronal loss in rat brain. Neuroscience. 69: 1095-1101. PMID 8848098 DOI: 10.1016/0306-4522(95)00300-8  1
1995 Tsai G, Coyle JT. N-acetylaspartate in neuropsychiatric disorders. Progress in Neurobiology. 46: 531-40. PMID 8532851 DOI: 10.1016/0301-0082(95)00014-M  1
1995 Peyser CE, Folstein M, Chase GA, Starkstein S, Brandt J, Cockrell JR, Bylsma F, Coyle JT, McHugh PR, Folstein SE. Trial of d-alpha-tocopherol in Huntington's disease. The American Journal of Psychiatry. 152: 1771-5. PMID 8526244  1
1995 Goff DC, Tsai G, Beal MF, Coyle JT. Tardive dyskinesia and substrates of energy metabolism in CSF. The American Journal of Psychiatry. 152: 1730-6. PMID 8526238  1
1995 Tsai G, Gastfriend DR, Coyle JT. The glutamatergic basis of human alcoholism. The American Journal of Psychiatry. 152: 332-40. PMID 7864257  1
1995 Baer L, Jacobs DG, Cukor P, O'Laughlen J, Coyle JT, Magruder KM. Automated telephone screening survey for depression. Jama. 273: 1943-4. PMID 7783305 DOI: 10.1001/jama.1995.03520480063041  1
1995 Berger UV, Carter RE, Coyle JT. The immunocytochemical localization of N-acetylaspartyl glutamate, its hydrolysing enzyme NAALADase, and the NMDAR-1 receptor at a vertebrate neuromuscular junction. Neuroscience. 64: 847-50. PMID 7753384 DOI: 10.1016/0306-4522(95)92578-8  1
1995 Berger UV, Carter RE, McKee M, Coyle JT. N-acetylated alpha-linked acidic dipeptidase is expressed by non-myelinating Schwann cells in the peripheral nervous system. Journal of Neurocytology. 24: 99-109. PMID 7745446 DOI: 10.1007/BF01181553  1
1995 Baer L, Cukor P, Jenike MA, Leahy L, O'Laughlen J, Coyle JT. Pilot studies of telemedicine for patients with obsessive-compulsive disorder. The American Journal of Psychiatry. 152: 1383-5. PMID 7653700  1
1995 Goff DC, Tsai G, Manoach DS, Coyle JT. Dose-finding trial of D-cycloserine added to neuroleptics for negative symptoms in schizophrenia. The American Journal of Psychiatry. 152: 1213-5. PMID 7625475  1
1995 Schwartz PJ, Berger UV, Coyle JT. Mice transgenic for copper/zinc superoxide dismutase exhibit increased markers of biogenic amine function. Journal of Neurochemistry. 65: 660-9. PMID 7616222  1
1995 Tsai G, Passani LA, Slusher BS, Carter R, Baer L, Kleinman JE, Coyle JT. Abnormal excitatory neurotransmitter metabolism in schizophrenic brains. Archives of General Psychiatry. 52: 829-36. PMID 7575102 DOI: 10.1001/archpsyc.1995.03950220039008  1
1995 Coyle JT. Food for thought. Nature Medicine. 1: 1006-7. PMID 7489354  1
1994 Vornov JJ, Tasker RC, Coyle JT. Delayed protection by MK-801 and tetrodotoxin in a rat organotypic hippocampal culture model of ischemia. Stroke; a Journal of Cerebral Circulation. 25: 457-64; discussion 4. PMID 8303757  1
1994 Kitt CA, Höhmann C, Coyle JT, Price DL. Cholinergic innervation of mouse forebrain structures. The Journal of Comparative Neurology. 341: 117-29. PMID 8006218 DOI: 10.1002/cne.903410110  1
1994 Bachman ES, Berger-Sweeney J, Coyle JT, Hohmann CF. Developmental regulation of adult cortical morphology and behavior: an animal model for mental retardation. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. 12: 239-53. PMID 7976481 DOI: 10.1016/0736-5748(94)90071-X  1
1993 Goodwin FK, Alfred DC, Coyle JT, Fox JC, Hollings RL, Jackson JS, Lagomarsino N, Matarazzo JD, McGaugh JL, Purpura DP, Shumway DL, Tucker GJ, Healy B, Suchinsky RT, Scaramozzino JA. Health care reform for americans with severe mental illnesses: Report of the national advisory mental health council American Journal of Psychiatry. 150: 1447-1465. PMID 8379547  1
1993 Puttfarcken PS, Handen JS, Montgomery DT, Coyle JT, Werling LL. N-acetyl-aspartylglutamate modulation of N-methyl-D-aspartate-stimulated [3H]norepinephrine release from rat hippocampal slices. The Journal of Pharmacology and Experimental Therapeutics. 266: 796-803. PMID 8355209  1
1993 Puttfarcken PS, Getz RL, Coyle JT. Kainic acid-induced lipid peroxidation: protection with butylated hydroxytoluene and U78517F in primary cultures of cerebellar granule cells. Brain Research. 624: 223-32. PMID 8252395 DOI: 10.1016/0006-8993(93)90081-W  1
1993 Tsai G, Cork LC, Slusher BS, Price D, Coyle JT. Abnormal acidic amino acids and N-acetylaspartylglutamate in hereditary canine motoneuron disease. Brain Research. 629: 305-9. PMID 8111634 DOI: 10.1016/0006-8993(93)91335-P  1
1993 Tsai G, Slusher BS, Sim L, Coyle JT. Immunocytochemical distribution of N-acetylaspartylglutamate in the rat forebrain and glutamatergic pathways. Journal of Chemical Neuroanatomy. 6: 277-92. PMID 7903856 DOI: 10.1016/0891-0618(93)90033-Z  1
1993 Coyle JT, Puttfarcken P. Oxidative stress, glutamate, and neurodegenerative disorders. Science (New York, N.Y.). 262: 689-95. PMID 7901908  1
1992 Slusher BS, Tsai G, Yoo G, Coyle JT. Immunocytochemical localization of the N-acetyl-aspartyl-glutamate (NAAG) hydrolyzing enzyme N-acetylated alpha-linked acidic dipeptidase (NAALADase). The Journal of Comparative Neurology. 315: 217-29. PMID 1545010 DOI: 10.1002/cne.903150208  1
1992 Robinson MB, Anegawa NJ, Gorry E, Qureshi IA, Coyle JT, Lucki I, Batshaw ML. Brain serotonin2 and serotonin1A receptors are altered in the congenitally hyperammonemic sparse fur mouse. Journal of Neurochemistry. 58: 1016-22. PMID 1531355  1
1992 Meyerhoff JL, Carter RE, Yourick DL, Slusher BS, Coyle JT. Genetically epilepsy-prone rats have increased brain regional activity of an enzyme which liberates glutamate from N-acetyl-aspartyl-glutamate. Brain Research. 593: 140-3. PMID 1360862 DOI: 10.1016/0006-8993(92)91276-K  1
1992 Meyerhoff JL, Robinson MB, Koller KJ, Bixler MA, Coyle JT. Kindling increases brain levels of NAAG and seizures reduce activity of a NAAG-hydrolyzing enzyme, NAALADase. Epilepsy Research. Supplement. 8: 297-305. PMID 1358101  1
1992 Meyerhoff JL, Carter RE, Yourick DL, Slusher BS, Coyle JT. Activity of a NAAG-hydrolyzing enzyme in brain may affect seizure susceptibility in genetically epilepsy-prone rats. Epilepsy Research. Supplement. 9: 163-72. PMID 1285905  1
1991 Yamada K, Saltarelli MD, Coyle JT. Effects of calmodulin antagonists on sodium-dependent high-affinity choline uptake. Brain Research. 542: 132-4. PMID 2054651 DOI: 10.1016/0006-8993(91)91006-M  1
1991 Piven J, Tsai GC, Nehme E, Coyle JT, Chase GA, Folstein SE. Platelet serotonin, a possible marker for familial autism. Journal of Autism and Developmental Disorders. 21: 51-9. PMID 2037549 DOI: 10.1007/BF02206997  1
1991 Coyle JT, Oster-Granite ML, Reeves R, Hohmann C, Corsi P, Gearhart J. Down syndrome and the trisomy 16 mouse: impact of gene imbalance on brain development and aging. Research Publications - Association For Research in Nervous and Mental Disease. 69: 85-99. PMID 1825889  1
1991 Simmons ML, Frondoza CG, Coyle JT. Immunocytochemical localization of N-acetyl-aspartate with monoclonal antibodies. Neuroscience. 45: 37-45. PMID 1754068 DOI: 10.1016/0306-4522(91)90101-S  1
1991 McKinney M, Coyle JT. The potential for muscarinic receptor subtype-specific pharmacotherapy for Alzheimer's disease. Mayo Clinic Proceedings. 66: 1225-37. PMID 1749291  0.52
1991 Murphy TH, De Long MJ, Coyle JT. Enhanced NAD(P)H:quinone reductase activity prevents glutamate toxicity produced by oxidative stress. Journal of Neurochemistry. 56: 990-5. PMID 1704427  1
1991 Coyle JT, Murphy TH, Puttfarcken PS, Lyons EW, Vornov JJ. The non-excitatory mechanisms of glutamate induced neurotoxicity. Epilepsy Research. 10: 41-8. PMID 1686428 DOI: 10.1016/0920-1211(91)90093-U  1
1991 Rothstein JD, Kuncl R, Chaudhry V, Clawson L, Cornblath DR, Coyle JT, Drachman DB. Excitatory amino acids in amyotrophic lateral sclerosis: an update. Annals of Neurology. 30: 224-5. PMID 1680305 DOI: 10.1002/ana.410300223  1
1991 Yamada K, Saltarelli MD, Coyle JT. [3H]hemicholinium-3 binding in rats with status epilepticus induced by lithium chloride and pilocarpine. European Journal of Pharmacology. 195: 395-7. PMID 1651249 DOI: 10.1016/0014-2999(91)90481-5  1
1990 Rothstein JD, Tsai G, Kuncl RW, Clawson L, Cornblath DR, Drachman DB, Pestronk A, Stauch BL, Coyle JT. Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis. Annals of Neurology. 28: 18-25. PMID 2375630 DOI: 10.1002/ana.410280106  1
1990 Lowenstein PR, Joyce JN, Coyle JT, Marshall JF. Striosomal organization of cholinergic and dopaminergic uptake sites and cholinergic M1 receptors in the adult human striatum: a quantitative receptor autoradiographic study. Brain Research. 510: 122-6. PMID 2322836 DOI: 10.1016/0006-8993(90)90736-U  1
1990 Frondoza CG, Logan S, Forloni G, Coyle JT. Production and characterization of monoclonal antibodies to N-acetyl-aspartyl-glutamate. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 38: 493-502. PMID 2319120  0.36
1990 Saltarelli MD, Yamada K, Coyle JT. Phospholipase A2 and 3H-hemicholinium-3 binding sites in rat brain: a potential second-messenger role for fatty acids in the regulation of high-affinity choline uptake. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 10: 62-72. PMID 2299401  1
1990 Sweeney JE, Bachman ES, Coyle JT. Effects of different doses of galanthamine, a long-acting acetylcholinesterase inhibitor, on memory in mice. Psychopharmacology. 102: 191-200. PMID 2274601  0.64
1990 Slusher BS, Robinson MB, Tsai G, Simmons ML, Richards SS, Coyle JT. Rat brain N-acetylated alpha-linked acidic dipeptidase activity. Purification and immunologic characterization. The Journal of Biological Chemistry. 265: 21297-301. PMID 2250024  1
1990 Murphy TH, Schnaar RL, Coyle JT. Immature cortical neurons are uniquely sensitive to glutamate toxicity by inhibition of cystine uptake. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 4: 1624-33. PMID 2180770  1
1990 Höhmann CF, Capone G, Oster-Granite ML, Coyle JT. Transplantation of brain tissue from murine trisomy 16 into euploid hosts: effects of gene imbalance on brain development. Progress in Brain Research. 82: 203-14. PMID 2149768  1
1990 Tsai G, Stauch BL, Vornov JJ, Deshpande JK, Coyle JT. Selective release of N-acetylaspartylglutamate from rat optic nerve terminals in vivo. Brain Research. 518: 313-6. PMID 1975216 DOI: 10.1016/0006-8993(90)90989-O  1
1990 Forloni G, Hohmann C, Coyle JT. Developmental expression of somatostatin in mouse brain. I. Immunocytochemical studies. Brain Research. Developmental Brain Research. 53: 6-25. PMID 1972042 DOI: 10.1016/0165-3806(90)90120-N  1
1990 Bendotti C, Hohmann C, Forloni G, Reeves R, Coyle JT, Oster-Granite ML. Developmental expression of somatostatin in mouse brain. II. In situ hybridization. Brain Research. Developmental Brain Research. 53: 26-39. PMID 1972040 DOI: 10.1016/0165-3806(90)90121-E  1
1989 Lowenstein PR, Slesinger PA, Singer HS, Walker LC, Casanova MF, Raskin LS, Price DL, Coyle JT. Compartment-specific changes in the density of choline and dopamine uptake sites and muscarinic and dopaminergic receptors during the development of the baboon striatum: a quantitative receptor autoradiographic study. The Journal of Comparative Neurology. 288: 428-46. PMID 2794143 DOI: 10.1002/cne.902880306  1
1989 Miyamoto M, Murphy TH, Schnaar RL, Coyle JT. Antioxidants protect against glutamate-induced cytotoxicity in a neuronal cell line. The Journal of Pharmacology and Experimental Therapeutics. 250: 1132-40. PMID 2778712  1
1989 Forloni G, Blake K, Hohmann CH, Coyle JT. The postnatal expression of acetylcholinesterase in somatostatin-positive cells of mouse hippocampus. Brain Research. Developmental Brain Research. 48: 73-85. PMID 2752576  0.36
1989 Yamada K, Saltarelli MD, Coyle JT. Specificity of the activation of [3H]hemicholinium-3 binding by phospholipase A2. The Journal of Pharmacology and Experimental Therapeutics. 249: 836-42. PMID 2732947  1
1989 Stauch BL, Robinson MB, Forloni G, Tsai G, Coyle JT. The effects of N-acetylated alpha-linked acidic dipeptidase (NAALADase) inhibitors on [3H]NAAG catabolism in vivo. Neuroscience Letters. 100: 295-300. PMID 2668802 DOI: 10.1016/0304-3940(89)90702-7  1
1989 Meyerhoff JL, Robinson MB, Bixler MA, Richards SS, Coyle JT. Seizures decrease regional enzymatic hydrolysis of N-acetyl-aspartylglutamate in rat brain. Brain Research. 505: 130-4. PMID 2611666 DOI: 10.1016/0006-8993(89)90123-6  1
1989 Murphy TH, Miyamoto M, Sastre A, Schnaar RL, Coyle JT. Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress. Neuron. 2: 1547-58. PMID 2576375 DOI: 10.1016/0896-6273(89)90043-3  1
1989 Ma W, Höhmann CF, Coyle JT, Juliano SL. Lesions of the basal forebrain alter stimulus-evoked metabolic activity in mouse somatosensory cortex. The Journal of Comparative Neurology. 288: 414-27. PMID 2551936 DOI: 10.1002/cne.902880305  1
1988 Guarda AS, Robinson MB, Ory-Lavollée L, Forloni GL, Blakely RD, Coyle JT. Quantitation of N-acetyl-aspartyl-glutamate in microdissected rat brain nuclei and peripheral tissues: findings with a novel liquid phase radioimmunoassay. Brain Research. 427: 223-31. PMID 3401700  0.96
1988 Robertson RT, Höhmann CF, Bruce JL, Coyle JT. Neonatal enucleations reduce specific activity of acetylcholinesterase but not choline acetyltransferase in developing rat visual cortex. Brain Research. 467: 298-302. PMID 3378178 DOI: 10.1016/0165-3806(88)90034-X  1
1988 Batshaw ML, Hyman SL, Coyle JT, Robinson MB, Qureshi IA, Mellits ED, Quaskey S. Effect of sodium benzoate and sodium phenylacetate on brain serotonin turnover in the ornithine transcarbamylase-deficient sparse-fur mouse. Pediatric Research. 23: 368-74. PMID 3374991 DOI: 10.1203/00006450-198804000-00006  0.44
1988 Yamada K, Saltarelli MD, Coyle JT. Solubilization and characterization of a [3H]hemicholinium-3 binding site in rat brain. Journal of Neurochemistry. 50: 1759-64. PMID 3373214  1
1988 Blakely RD, Robinson MB, Thompson RC, Coyle JT. Hydrolysis of the brain dipeptide N-acetyl-L-aspartyl-L-glutamate: subcellular and regional distribution, ontogeny, and the effect of lesions on N-acetylated-alpha-linked acidic dipeptidase activity. Journal of Neurochemistry. 50: 1200-9. PMID 3346674  0.96
1988 Hohmann CF, Brooks AR, Coyle JT. Neonatal lesions of the basal forebrain cholinergic neurons result in abnormal cortical development. Brain Research. 470: 253-64. PMID 3219585 DOI: 10.1016/0165-3806(88)90244-1  1
1988 Yamada K, Saltarelli MD, Coyle JT. Involvement of phospholipase A2 in the regulation of [3H]hemicholinium-3 binding. Biochemical Pharmacology. 37: 4367-73. PMID 3196359 DOI: 10.1016/0006-2952(88)90619-3  1
1988 Tsai G, Forloni G, Robinson MB, Stauch BL, Coyle JT. Calcium-dependent evoked release of N-[3H]acetylaspartylglutamate from the optic pathway. Journal of Neurochemistry. 51: 1956-9. PMID 3183672  1
1988 Saltarelli MD, Lopez J, Lowenstein PR, Coyle JT. The role of calcium in the regulation of [3H]hemicholinium-3 binding sites in rat brain. Neuropharmacology. 27: 1301-8. PMID 3149725 DOI: 10.1016/0028-3908(88)90034-2  1
1988 Blakely RD, Coyle JT. The neurobiology of N-acetylaspartylglutamate. International Review of Neurobiology. 30: 39-100. PMID 3061970  0.96
1988 O'Hara BF, Bendotti C, Reeves RH, Oster-Granite ML, Coyle JT, Gearhart JD. Genetic mapping and analysis of somatostatin expression in Snell dwarf mice. Brain Research. 464: 283-92. PMID 2906811 DOI: 10.1016/0169-328X(88)90037-X  1
1988 Murphy TH, Schnaar RL, Coyle JT, Sastre A. Glutamate cytotoxicity in a neuronal cell line is blocked by membrane depolarization. Brain Research. 460: 155-60. PMID 2905921 DOI: 10.1016/0006-8993(88)91216-4  1
1988 Bendotti C, Forloni GL, Morgan RA, O'Hara BF, Oster-Granite ML, Reeves RH, Gearhart JD, Coyle JT. Neuroanatomical localization and quantification of amyloid precursor protein mRNA by in situ hybridization in the brains of normal, aneuploid, and lesioned mice. Proceedings of the National Academy of Sciences of the United States of America. 85: 3628-32. PMID 2897124  1
1988 Murphy TH, Malouf AT, Sastre A, Schnaar RL, Coyle JT. Calcium-dependent glutamate cytotoxicity in a neuronal cell line. Brain Research. 444: 325-32. PMID 2896063 DOI: 10.1016/0006-8993(88)90941-9  1
1988 Blakely RD, Robinson MB, Guarda AS, Coyle JT. A re-examination of the interaction of N-acetyl-L-aspartyl-L-glutamate with a subpopulation of rat brain membrane L-[3H]glutamate binding sites. European Journal of Pharmacology. 151: 419-26. PMID 2850921  0.96
1988 Slesinger PA, Lowenstein PR, Singer HS, Walker LC, Casanova MF, Price DL, Coyle JT. Development of beta 1 and beta 2 adrenergic receptors in baboon brain: an autoradiographic study using [125I]iodocyanopindolol. The Journal of Comparative Neurology. 273: 318-29. PMID 2850303 DOI: 10.1002/cne.902730304  1
1988 Coyle JT, Oster-Granite ML, Reeves RH, Gearhart JD. Down syndrome, Alzheimer's disease and the trisomy 16 mouse. Trends in Neurosciences. 11: 390-4. PMID 2469204 DOI: 10.1016/0166-2236(88)90075-6  1
1988 Hohmann CF, Hamon R, Batshaw ML, Coyle JT. Transient postnatal elevation of serotonin levels in mouse neocortex. Brain Research. 471: 163-6. PMID 2464412 DOI: 10.1016/0165-3806(88)90163-0  1
1987 Hohmann GF, Wenk GL, Lowenstein P, Brown ME, Coyle JT. Age-related recurrence of basal forebrain lesion-induced cholinergic deficits. Neuroscience Letters. 82: 253-9. PMID 3696497 DOI: 10.1016/0304-3940(87)90265-5  1
1987 Blakely RD, Ory-Lavollée L, Coyle JT. Specific alterations in the levels of N-acetyl-aspartyl-glutamate in the nervous system of the dystrophic mouse. Neuroscience Letters. 79: 223-8. PMID 3670731  0.96
1987 Robinson MB, Blakely RD, Couto R, Coyle JT. Hydrolysis of the brain dipeptide N-acetyl-L-aspartyl-L-glutamate. Identification and characterization of a novel N-acetylated alpha-linked acidic dipeptidase activity from rat brain. The Journal of Biological Chemistry. 262: 14498-506. PMID 3667587  0.96
1987 Lowenstein PR, Slesinger PA, Singer HS, Walker LC, Casanova MF, Price DL, Coyle JT. An autoradiographic study of the development of [3H]hemicholinium-3 binding sites in human and baboon basal ganglia: a marker for the sodium-dependent high affinity choline uptake system. Brain Research. 431: 291-7. PMID 3620993 DOI: 10.1016/0165-3806(87)90216-1  1
1987 Saltarelli MD, Lowenstein PR, Coyle JT. Rapid in vitro modulation of [3H]hemicholinium-3 binding sites in rat striatal slices. European Journal of Pharmacology. 135: 35-40. PMID 3569424 DOI: 10.1016/0014-2999(87)90754-0  1
1987 Ory-Lavollée L, Blakely RD, Coyle JT. Neurochemical and immunocytochemical studies on the distribution of N-acetyl-aspartylglutamate and N-acetyl-aspartate in rat spinal cord and some peripheral nervous tissues. Journal of Neurochemistry. 48: 895-9. PMID 3543223  0.96
1987 Forloni G, Grzanna R, Blakely RD, Coyle JT. Co-localization of N-acetyl-aspartyl-glutamate in central cholinergic, noradrenergic, and serotonergic neurons. Synapse (New York, N.Y.). 1: 455-60. PMID 3505373 DOI: 10.1002/syn.890010509  0.96
1987 Gearhart JD, Oster-Granite ML, Reeves RH, Coyle JT. Developmental consequences of autosomal aneuploidy in mammals. Developmental Genetics. 8: 249-65. PMID 2971493 DOI: 10.1002/dvg.1020080408  1
1987 Reeves RH, Robakis NK, Oster-Granite ML, Wisniewski HM, Coyle JT, Gearhart JD. Genetic linkage in the mouse of genes involved in Down syndrome and Alzheimer's disease in man. Brain Research. 388: 215-21. PMID 2960420 DOI: 10.1016/0169-328X(87)90028-3  1
1987 Saltarelli MD, Forloni GL, Oster-Granite ML, Gearhart JD, Coyle JT. Neurochemical characterization of embryonic brain development in trisomy 19 (Ts19) mice: implications of selective deficits observed for abnormal neural development in aneuploidy. Developmental Genetics. 8: 267-79. PMID 2901927 DOI: 10.1002/dvg.1020080409  1
1987 Robinson MB, Coyle JT. Glutamate and related acidic excitatory neurotransmitters: from basic science to clinical application. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 1: 446-55. PMID 2890549  0.44
1987 Braitman DJ, Coyle JT. Inhibition of [3H]kainic acid receptor binding by divalent cations correlates with ion affinity for the calcium channel. Neuropharmacology. 26: 1247-51. PMID 2444898 DOI: 10.1016/0028-3908(87)90083-9  1
1987 Blakely RD, Ory-Lavollée L, Grzanna R, Koller KJ, Coyle JT. Selective immunocytochemical staining of mitral cells in rat olfactory bulb with affinity purified antibodies against N-acetyl-aspartyl-glutamate. Brain Research. 402: 373-8. PMID 2435366  0.96
1986 Clark AW, Manz HJ, White CL, Lehmann J, Miller D, Coyle JT. Cortical degeneration with swollen chromatolytic neurons: its relationship to Pick's disease. Journal of Neuropathology and Experimental Neurology. 45: 268-84. PMID 3958759  1
1986 Batshaw ML, Hyman SL, Mellits ED, Thomas GH, DeMuro R, Coyle JT. Behavioral and neurotransmitter changes in the urease-infused rat: a model of congenital hyperammonemia. Pediatric Research. 20: 1310-5. PMID 3797124 DOI: 10.1203/00006450-198612000-00025  0.36
1986 Clark AW, White CL, Manz HJ, Parhad IM, Curry B, Whitehouse PJ, Lehmann J, Coyle JT. Primary degenerative dementia without Alzheimer pathology. The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques. 13: 462-70. PMID 3791063 DOI: 10.1017/S0317167100037136  1
1986 Whitehouse PJ, Martino AM, Antuono PG, Lowenstein PR, Coyle JT, Price DL, Kellar KJ. Nicotinic acetylcholine binding sites in Alzheimer's disease. Brain Research. 371: 146-51. PMID 3708340 DOI: 10.1016/0006-8993(86)90819-X  1
1986 Robinson MB, Blakely RD, Coyle JT. Quisqualate selectively inhibits a brain peptidase which cleaves N-acetyl-L-aspartyl-L-glutamate in vitro. European Journal of Pharmacology. 130: 345-7. PMID 3539626  0.96
1986 Grob CS, Coyle JT. Suspected adverse methylphenidate-imipramine interactions in children. Journal of Developmental and Behavioral Pediatrics : Jdbp. 7: 265-7. PMID 3018047  1
1986 Coyle JT, Blakely R, Zaczek R, Koller KJ, Abreu M, Ory-Lavollée L, Fisher R, ffrench-Mullen JM, Carpenter DO. Acidic peptides in brain: do they act at putative glutamatergic synapses? Advances in Experimental Medicine and Biology. 203: 375-84. PMID 2878566  1
1986 ffrench-Mullen JM, Murphy TH, Coyle JT, Fisher RS. Dicarboxylic amino acids block epileptiform activity in hippocampal slice. Epilepsia. 27: 678-84. PMID 2877868  1
1986 Gearhart JD, Singer HS, Moran TH, Tiemeyer M, Oster-Granite ML, Coyle JT. Mouse chimeras composed of trisomy 16 and normal (2N) cells: preliminary studies. Brain Research Bulletin. 16: 815-24. PMID 2875771 DOI: 10.1016/0361-9230(86)90077-8  1
1986 Blakely RD, Ory-Lavollée L, Thompson RC, Coyle JT. Synaptosomal transport of radiolabel from N-acetyl-aspartyl-[3H]glutamate suggests a mechanism of inactivation of an excitatory neuropeptide. Journal of Neurochemistry. 47: 1013-9. PMID 2875126  0.96
1986 Struble RG, Lehmann J, Mitchell SJ, McKinney M, Price DL, Coyle JT, DeLong MR. Basal forebrain neurons provide major cholinergic innervation of primate neocortex. Neuroscience Letters. 66: 215-20. PMID 2425286 DOI: 10.1016/0304-3940(86)90193-X  1
1986 Hyman SL, Coyle JT, Parke JC, Porter C, Thomas GH, Jankel W, Batshaw ML. Anorexia and altered serotonin metabolism in a patient with argininosuccinic aciduria. The Journal of Pediatrics. 108: 705-9. PMID 2422338  0.36
1985 Sanberg PR, Pevsner J, Autuono PG, Coyle JT. Fetal methylazoxymethanol acetate-induced lesions cause reductions in dopamine receptor-mediated catalepsy and stereotypy. Neuropharmacology. 24: 1057-62. PMID 4080104 DOI: 10.1016/0028-3908(85)90191-1  1
1985 Meyerhoff JL, Koller KJ, Walczak DD, Coyle JT. Regional brain levels of N-acetyl-aspartyl-glutamate: the effect of kindled seizures. Brain Research. 346: 392-6. PMID 4052789 DOI: 10.1016/0006-8993(85)90877-7  1
1985 Hepler DJ, Wenk GL, Cribbs BL, Olton DS, Coyle JT. Memory impairments following basal forebrain lesions. Brain Research. 346: 8-14. PMID 4052773 DOI: 10.1016/0006-8993(85)91088-1  1
1985 Knowlton BJ, Wenk GL, Olton DS, Coyle JT. Basal forebrain lesions produce a dissociation of trial-dependent and trial-independent memory performance. Brain Research. 345: 315-21. PMID 4041891 DOI: 10.1016/0006-8993(85)91008-X  1
1985 Hepler DJ, Olton DS, Wenk GL, Coyle JT. Lesions in nucleus basalis magnocellularis and medial septal area of rats produce qualitatively similar memory impairments. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 5: 866-73. PMID 4038997  1
1985 Strauss ME, Lew MF, Coyle JT, Tune LE. Psychopharmacologic and clinical correlates of attention in chronic schizophrenia. The American Journal of Psychiatry. 142: 497-9. PMID 3976926  1
1985 Gutterman DF, Correa EI, DePaulo JR, Coyle JT. RBC choline and renal disorders during lithium treatment. The American Journal of Psychiatry. 142: 493-5. PMID 3976925  0.52
1985 Sandberg K, Schnaar RL, Coyle JT. Method for the quantitation and characterization of the cholinergic neurotoxin, monoethylcholine mustard aziridinium ion (AF64A). Journal of Neuroscience Methods. 14: 143-8. PMID 3839874 DOI: 10.1016/0165-0270(85)90127-X  1
1985 Koller KJ, Coyle JT. The characterization of the specific binding of [3H]-N-acetylaspartylglutamate to rat brain membranes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 5: 2882-8. PMID 2865340  0.52
1984 Coyle JT, Singer H, Beaulieu M, Johnston MV. Development of central neurotransmitter-specified neuronal systems: implications for pediatric neuro-psychiatric disorders. Acta Neurologica Scandinavica. 70: 1-11. PMID 6147947  0.96
1983 Coyle JT, McKinney M, Johnston MV, Hedreen JC. Synaptic neurochemistry of the basal forebrain cholinergic projection. Psychopharmacology Bulletin. 19: 441-7. PMID 6635121  0.96
1982 Slevin JT, Johnston MV, Biziere K, Coyle JT. Methylazoxymethanol acetate ablation of mouse cerebellar granule cells: effects on synaptic neurochemistry. Developmental Neuroscience. 5: 3-12. PMID 6125372  0.96
1982 Johnston MV, Haddad R, Carman-Young A, Coyle JT. Neurotransmitter chemistry of lissencephalic cortex induced in ferrets by fetal treatment with methylazoxymethanol acetate. Brain Research. 256: 285-91. PMID 6125249  0.96
1981 Johnston MV, Young AC, Coyle JT. Laminar distribution of cholinergic markers in neocortex: effects of lesions. Journal of Neuroscience Research. 6: 597-607. PMID 7321061 DOI: 10.1002/jnr.490060506  0.96
1981 Olschowka JA, Molliver ME, Grzanna R, Rice FL, Coyle JT. Ultrastructural demonstration of noradrenergic synapses in the rat central nervous system by dopamine-beta-hydroxylase immunocytochemistry. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 29: 271-80. PMID 7019303  1
1981 Morrison JH, Molliver ME, Grzanna R, Coyle JT. The intra-cortical trajectory of the coeruleo-cortical projection in the rat: a tangentially organized cortical afferent. Neuroscience. 6: 139-58. PMID 7012664 DOI: 10.1016/0306-4522(81)90051-8  1
1981 Johnston MV, McKinney M, Coyle JT. Neocortical cholinergic innervation: a description of extrinsic and intrinsic components in the rat. Experimental Brain Research. 43: 159-72. PMID 6265265  0.96
1981 Johnston MV, Coyle JT. Development of central neurotransmitter systems. Ciba Foundation Symposium. 86: 251-70. PMID 6121688  0.96
1981 Johnston MV, Carman AB, Coyle JT. Effects of fetal treatment with methylazoxymethanol acetate at various gestational dates on the neurochemistry of the adult neocortex of the rat. Journal of Neurochemistry. 36: 124-8. PMID 6109753  0.96
1980 Coyle JT, Johnston MV. Functional hyperinnervation of cerebral cortex by noradrenergic neurons results from fetal lesions: parallels with schizophrenia. Psychopharmacology Bulletin. 16: 27-9. PMID 7189061  0.96
1980 Johnston MV, Coyle JT. Ontogeny of neurochemical markers for noradrenergic, GABAergic, and cholinergic neurons in neocortex lesioned with methylazoxymethanol acetate. Journal of Neurochemistry. 34: 1429-41. PMID 6103916  0.96
1980 Tune LE, Creese I, Depaulo JR, Slavney PR, Coyle JT, Snyder SH. Clinical state and serum neuroleptic levels measured by radioreceptor assay in schizophrenia. The American Journal of Psychiatry. 137: 187-90. PMID 6101524  1
1980 Tune LE, Creese I, Coyle JT, Pearlson G, Snyder SH. Low neuroleptic serum levels in patients receiving fluphenazine decanoate. The American Journal of Psychiatry. 137: 80-2. PMID 6101523  1
1979 Morrison JH, Molliver ME, Grzanna R, Coyle JT. Noradrenergic innervation patterns in three regions of medial cortex: an immunofluorescence characterization. Brain Research Bulletin. 4: 849-57. PMID 393366 DOI: 10.1016/0361-9230(79)90022-4  1
1979 Johnston MV, McKinney M, Coyle JT. Evidence for a cholinergic projection to neocortex from neurons in basal forebrain. Proceedings of the National Academy of Sciences of the United States of America. 76: 5392-6. PMID 388436  0.96
1979 Johnston MV, Coyle JT. Histological and neurochemical effects of fetal treatment with methylazoxymethanol on rat neocortex in adulthood. Brain Research. 170: 135-55. PMID 37983  0.96
1979 Johnston MV, Grzanna R, Coyle JT. Methylazoxymethanol treatment of fetal rats results in abnormally dense noradrenergic innervation of neocortex. Science (New York, N.Y.). 203: 369-71. PMID 32620  0.96
1978 Coyle JT, Molliver ME, Kuhar MJ. In situ injection of kainic acid: a new method for selectively lesioning neural cell bodies while sparing axons of passage. The Journal of Comparative Neurology. 180: 301-23. PMID 659663 DOI: 10.1002/cne.901800208  1
1978 Schwarcz R, Creese I, Coyle JT, Snyder SH. Dopamine receptors localised on cerebral cortical afferents to rat corpus striatum. Nature. 271: 766-8. PMID 625348 DOI: 10.1038/27766a0  1
1978 Morrison JH, Grzanna R, Molliver ME, Coyle JT. The distribution and orientation of noradrenergic fibers in neocortex of the rat: an immunofluorescence study. The Journal of Comparative Neurology. 181: 17-39. PMID 355267 DOI: 10.1002/cne.901810103  1
1978 Grzanna R, Molliver ME, Coyle JT. Visualization of central noradrenergic neurons in thick sections by the unlabeled antibody method: a transmitter-specific Golgi image. Proceedings of the National Academy of Sciences of the United States of America. 75: 2502-6. PMID 353813  1
1978 Childers SR, Schwarcz R, Coyle JT, Snyder SH. Radioimmunoassay of enkephalins: levels of methionine- and leucine-enkephalin in morphine-dependent and kainic acid-lesioned rat brains. Advances in Biochemical Psychopharmacology. 18: 161-73. PMID 206108  1
1977 Grzanna R, Morrison JH, Coyle JT, Molliver ME. The immunohistochemical demonstration of noradrenergic neurons in the rat brain: The use of homologous antiserum to dopamine-beta-hydroxylase. Neuroscience Letters. 4: 127-34. PMID 19604933  1
1977 Coyle JT, Molliver ME. Major innervation of newborn rat cortex by monoaminergic neurons. Science (New York, N.Y.). 196: 444-7. PMID 850788  1
1974 Saavedra JM, Coyle JT, Axelrod J. Developmental characteristics of phenylethanolamine and octopamine in the rat brain. Journal of Neurochemistry. 23: 511-5. PMID 4153859  1
1974 Coyle JT, Wooten GF, Axelrod J. Evidence for extranoradrenergic dopamine-beta-hydroxylase activity in rat salivary gland. Journal of Neurochemistry. 22: 923-9. PMID 4152880  1
1973 Saavedra JM, Coyle JT, Axelrod J. The distribution and properties of the nonspecific N-methyltransferase in brain. Journal of Neurochemistry. 20: 743-52. PMID 4703789  1
1973 Coyle JT, Jacobowitz D, Klein D, Axelrod J. Dopaminergic neurons in explants of substantia nigra in culture. Journal of Neurobiology. 4: 461-70. PMID 4147763 DOI: 10.1002/neu.480040507  1
1972 Coyle JT, Axelrod J. Dopamine- -hydroxylase in the rat brain: developmental characteristics. Journal of Neurochemistry. 19: 449-59. PMID 4621978  1
1972 Coyle JT, Axelrod J. Tyrosine hydroxylase in rat brain: developmental characteristics. Journal of Neurochemistry. 19: 1117-23. PMID 4401682  1
1972 Snyder SH, Taylor KM, Horn AS, Coyle JT. Psychoactive drugs and neurotransmitters: differentiating dopamine and norepinephrine neuronal functions with drugs. Research Publications - Association For Research in Nervous and Mental Disease. 50: 359-75. PMID 4341952  1
1971 Horn AS, Coyle JT, Snyder SH. Catecholamine uptake by synaptosomes from rat brain. Structure-activity relationships of drugs with differential effects on dopamine and norepinephrine neurons. Molecular Pharmacology. 7: 66-80. PMID 5552252  1
1971 Coyle JT, Axelrod J. Development of the uptake and storage of L-( 3 H)norepinephrine in the rat brain. Journal of Neurochemistry. 18: 2061-75. PMID 5129345  1
1970 Snyder SH, Taylor KM, Coyle JT, Meyerhoff JL. The role of brain dopamine in behavioral regulation and the actions of psychotropic drugs. The American Journal of Psychiatry. 127: 199-207. PMID 4319649  1
1969 Snyder SH, Coyle JT. Regional differences in H3-norepinephrine and H3-dopamine uptake into rat brain homogenates. The Journal of Pharmacology and Experimental Therapeutics. 165: 78-86. PMID 5782836  1
1969 Coyle JT, Snyder SH. Antiparkinsonian drugs: inhibition of dopamine uptake in the corpus striatum as a possible mechanism of action. Science (New York, N.Y.). 166: 899-901. PMID 5345207  1
1969 Coyle JT, Snyder SH. Catecholamine uptake by synaptosomes in homogenates of rat brain: stereospecificity in different areas. The Journal of Pharmacology and Experimental Therapeutics. 170: 221-31. PMID 4982310  1
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