Joseph T. Coyle - Publications

Harvard Medical School, Boston, MA, United States 

306 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Coyle JT, Schwarcz R. The Discovery and Characterization of Targeted Perikaryal-Specific Brain Lesions With Excitotoxins. Frontiers in Neuroscience. 14: 927. PMID 33013307 DOI: 10.3389/fnins.2020.00927  0.416
2020 Takagi S, Puhl MD, Anderson T, Balu DT, Coyle JT. Serine Racemase Expression by Striatal Neurons. Cellular and Molecular Neurobiology. PMID 32445040 DOI: 10.1007/S10571-020-00880-9  0.775
2020 Coyle JT, Balu D, Wolosker H. D-Serine, the Shape-Shifting NMDA Receptor Co-agonist. Neurochemical Research. PMID 32189130 DOI: 10.1007/S11064-020-03014-1  0.373
2020 Jimenez NT, Lines JW, Kueppers RB, Kofuji P, Wei H, Rankila A, Coyle JT, Miller RF, McLoon LK. Electroretinographic Abnormalities and Sex Differences Detected with Mesopic Adaptation in a Mouse Model of Schizophrenia: A and B Wave Analysis. Investigative Ophthalmology & Visual Science. 61: 16. PMID 32053730 DOI: 10.1167/Iovs.61.2.16  0.345
2019 Bodkin JA, Coleman MJ, Godfrey LJ, Carvalho CMB, Morgan CJ, Suckow RF, Anderson T, Ongur D, Kaufman MJ, Lewandowski KE, Siegel AJ, Waldstreicher E, Grochowski CM, Javitt DC, Rujescu D, ... ... Coyle JT, et al. Targeted Treatment of Individuals With Psychosis Carrying a Copy Number Variant Containing a Genomic Triplication of the Glycine Decarboxylase Gene. Biological Psychiatry. PMID 31279534 DOI: 10.1016/J.Biopsych.2019.04.031  0.503
2019 Balu DT, Pantazopoulos H, Huang CCY, Muszynski K, Harvey TL, Uno Y, Rorabaugh JM, Galloway CR, Botz-Zapp C, Berretta S, Weinshenker D, Coyle JT. Neurotoxic astrocytes express the d-serine synthesizing enzyme, serine racemase, in Alzheimer's disease. Neurobiology of Disease. 104511. PMID 31212068 DOI: 10.1016/J.Nbd.2019.104511  0.314
2019 Ni P, Noh H, Park GH, Shao Z, Guan Y, Park JM, Yu S, Park JS, Coyle JT, Weinberger DR, Straub RE, Cohen BM, McPhie DL, Yin C, Huang W, et al. iPSC-derived homogeneous populations of developing schizophrenia cortical interneurons have compromised mitochondrial function. Molecular Psychiatry. PMID 31019265 DOI: 10.1038/S41380-019-0423-3  0.359
2019 Uno Y, Coyle JT. Glutamate Hypothesis in Schizophrenia. Psychiatry and Clinical Neurosciences. PMID 30666759 DOI: 10.1111/pcn.12823  0.379
2019 Shao Z, Noh H, Bin Kim W, Ni P, Nguyen C, Cote SE, Noyes E, Zhao J, Parsons T, Park JM, Zheng K, Park JJ, Coyle JT, Weinberger DR, Straub RE, et al. Dysregulated protocadherin-pathway activity as an intrinsic defect in induced pluripotent stem cell-derived cortical interneurons from subjects with schizophrenia. Nature Neuroscience. PMID 30664768 DOI: 10.1038/S41593-018-0313-Z  0.385
2018 Konopaske GT, Balu DT, Presti KT, Chan G, Benes FM, Coyle JT. Dysbindin-1 contributes to prefrontal cortical dendritic arbor pathology in schizophrenia. Schizophrenia Research. PMID 29759351 DOI: 10.1016/J.Schres.2018.04.042  0.339
2018 Coyle JT, Balu DT. The Role of Serine Racemase in the Pathophysiology of Brain Disorders. Advances in Pharmacology (San Diego, Calif.). 82: 35-56. PMID 29413527 DOI: 10.1016/Bs.Apha.2017.10.002  0.436
2018 Li S, Uno Y, Rudolph U, Cobb J, Liu J, Anderson T, Levy D, Balu DT, Coyle JT. Astrocytes in Primary Cultures Express Serine Racemase, Synthesize D-Serine and Acquire A1 Reactive Astrocyte Features. Biochemical Pharmacology. PMID 29305854 DOI: 10.1016/J.Bcp.2017.12.023  0.323
2018 Cabungcal JH, Steullet P, Coyle J, Didriksen M, Gill K, Grace A, Takao H, LaMantia A, Lindemann L, Maynard T, Meyer U, Morishita H, O’Donnell P, Puhl M, Cuenod M, et al. 3.2 PARVALBUMIN INTERNEURON IMPAIRMENT INDUCED BY OXIDATIVE STRESS AS A COMMON PATHOLOGICAL MECHANISM IN ANIMAL MODELS OF SCHIZOPHRENIA Schizophrenia Bulletin. 44: S1-S2. DOI: 10.1093/Schbul/Sby014.004  0.743
2017 Balu DT, Coyle JT. Altered CREB Binding to Activity-Dependent Genes in Serine Racemase Deficient Mice, a Mouse Model of Schizophrenia. Acs Chemical Neuroscience. PMID 29172439 DOI: 10.1021/Acschemneuro.7B00404  0.375
2017 Puhl MD, Desai RI, Takagi S, Presti KT, Doyle MR, Donahue RJ, Landino SM, Bergman J, Carlezon WA, Coyle JT. N-Methyl-d-aspartate receptor co-agonist availability affects behavioral and neurochemical responses to cocaine: insights into comorbid schizophrenia and substance abuse. Addiction Biology. PMID 29168271 DOI: 10.1111/Adb.12577  0.774
2017 Ruzicka WB, Subburaju S, Coyle JT, Benes FM. Location Matters: Distinct DNA Methylation Patterns in GABAergic Interneuronal Populations from Separate Microcircuits within the Human Hippocampus. Human Molecular Genetics. PMID 29106556 DOI: 10.1093/Hmg/Ddx395  0.337
2017 Kim SY, Kaufman MJ, Cohen BM, Jensen JE, Coyle JT, Du F, Öngür D. In Vivo Brain Glycine and Glutamate Concentrations in Patients With First-Episode Psychosis Measured by Echo Time-Averaged Proton Magnetic Resonance Spectroscopy at 4T. Biological Psychiatry. PMID 29031411 DOI: 10.1016/J.Biopsych.2017.08.022  0.33
2017 Balu DT, Presti KT, Huang CCY, Muszynski K, Radzishevsky I, Wolosker H, Guffanti G, Ressler KJ, Coyle JT. Serine Racemase and D-serine in the Amygdala Are Dynamically Involved in Fear Learning. Biological Psychiatry. PMID 29025687 DOI: 10.1016/J.Biopsych.2017.08.012  0.329
2017 Wolosker H, Balu DT, Coyle JT. Astroglial Versus Neuronal D-Serine: Check Your Controls! Trends in Neurosciences. PMID 28756007 DOI: 10.1016/J.Tins.2017.06.010  0.331
2017 Perez EJ, Tapanes SA, Loris ZB, Balu DT, Sick TJ, Coyle JT, Liebl DJ. Enhanced astrocytic d-serine underlies synaptic damage after traumatic brain injury. The Journal of Clinical Investigation. PMID 28714867 DOI: 10.1172/Jci92300  0.343
2017 Coyle JT. Schizophrenia: Basic and Clinical. Advances in Neurobiology. 15: 255-280. PMID 28674984 DOI: 10.1007/978-3-319-57193-5_9  0.415
2017 Noh H, Shao Z, Coyle JT, Chung S. Modeling schizophrenia pathogenesis using patient-derived induced pluripotent stem cells (iPSCs). Biochimica Et Biophysica Acta. PMID 28668333 DOI: 10.1016/j.bbadis.2017.06.019  0.304
2017 Coyle JT. Cortical Pyramidal Neurons Show a Selective Loss of New Synapses in Chronic Schizophrenia. The American Journal of Psychiatry. 174: 510-511. PMID 28565949 DOI: 10.1176/appi.ajp.2017.17030318  0.355
2017 Tobe BTD, Crain AM, Winquist AM, Calabrese B, Makihara H, Zhao WN, Lalonde J, Nakamura H, Konopaske G, Sidor M, Pernia CD, Yamashita N, Wada M, Inoue Y, Nakamura F, ... ... Coyle JT, et al. Probing the lithium-response pathway in hiPSCs implicates the phosphoregulatory set-point for a cytoskeletal modulator in bipolar pathogenesis. Proceedings of the National Academy of Sciences of the United States of America. PMID 28500272 DOI: 10.1073/Pnas.1700111114  0.316
2017 Steullet P, Cabungcal JH, Coyle J, Didriksen M, Gill K, Grace AA, Hensch TK, LaMantia AS, Lindemann L, Maynard TM, Meyer U, Morishita H, O'Donnell P, Puhl M, Cuenod M, et al. Oxidative stress-driven parvalbumin interneuron impairment as a common mechanism in models of schizophrenia. Molecular Psychiatry. PMID 28322275 DOI: 10.1038/Mp.2017.47  0.753
2017 Levy D, Coleman M, Godfrey L, Morgan C, Sebat J, Ongur D, McCarthy S, Malhotra D, Vuckovic A, Smith K, Kirchhoff C, Suckow R, Coyle J, Rudolph U, Goff D, et al. SU93. Targeted Treatment of a Genetic Mutation in Glycine Decarboxylase With d-Cycloserine in Psychotic Disorders Schizophrenia Bulletin. 43: S194-S195. DOI: 10.1093/Schbul/Sbx024.089  0.313
2016 Wolosker H, Balu DT, Coyle JT. The Rise and Fall of the d-Serine-Mediated Gliotransmission Hypothesis. Trends in Neurosciences. PMID 27742076 DOI: 10.1016/J.Tins.2016.09.007  0.354
2016 Basu AC, Puhl MD, Coyle JT. Endogenous co-agonists of the NMDA receptor modulate contextual fear in trace conditioning. Neurobiology of Learning and Memory. PMID 27633914 DOI: 10.1016/J.Nlm.2016.09.006  0.788
2016 Perez EJ, Cepero ML, Perez SU, Coyle JT, Sick TJ, Liebl DJ. EphB3 signaling propagates synaptic dysfunction in the traumatic injured brain. Neurobiology of Disease. PMID 27317833 DOI: 10.1016/J.Nbd.2016.06.007  0.338
2016 Coyle JT, Balu DT, Puhl MD, Konopaske GT. History of the Concept of Disconnectivity in Schizophrenia. Harvard Review of Psychiatry. 24: 80-6. PMID 26954593 DOI: 10.1097/Hrp.0000000000000102  0.78
2016 Balu DT, Li Y, Takagi S, Presti KT, Ramikie TS, Rook JM, Jones CK, Lindsley CW, Conn PJ, Bolshakov VY, Coyle JT. An mGlu5 Positive Allosteric Modulator Rescues the Neuroplasticity Deficits in a Genetic Model of NMDA Receptor Hypofunction in Schizophrenia. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 26741285 DOI: 10.1038/Npp.2016.2  0.414
2015 Konopaske GT, Coyle JT. Possible compensatory mechanisms for glutamatergic disconnection found in the auditory cortex in schizophrenia. Biological Psychiatry. 77: 923-4. PMID 25959563 DOI: 10.1016/j.biopsych.2015.03.031  0.4
2015 Puhl MD, Berg AR, Bechtholt AJ, Coyle JT. Availability of N-Methyl-d-Aspartate Receptor Coagonists Affects Cocaine-Induced Conditioned Place Preference and Locomotor Sensitization: Implications for Comorbid Schizophrenia and Substance Abuse. The Journal of Pharmacology and Experimental Therapeutics. 353: 465-70. PMID 25788713 DOI: 10.1124/Jpet.115.223099  0.761
2015 Ishiwata S, Umino A, Balu DT, Coyle JT, Nishikawa T. Neuronal serine racemase regulates extracellular D-serine levels in the adult mouse hippocampus. Journal of Neural Transmission (Vienna, Austria : 1996). PMID 25782690 DOI: 10.1007/S00702-015-1388-2  0.401
2015 Konopaske GT, Subburaju S, Coyle JT, Benes FM. Altered prefrontal cortical MARCKS and PPP1R9A mRNA expression in schizophrenia and bipolar disorder. Schizophrenia Research. 164: 100-8. PMID 25757715 DOI: 10.1016/J.Schres.2015.02.005  0.333
2015 Takagi S, Balu DT, Coyle JT. Subchronic pharmacological and chronic genetic NMDA receptor hypofunction differentially regulate the Akt signaling pathway and Arc expression in juvenile and adult mice. Schizophrenia Research. 162: 216-21. PMID 25592804 DOI: 10.1016/J.Schres.2014.12.034  0.402
2015 Balu DT, Coyle JT. The NMDA receptor 'glycine modulatory site' in schizophrenia: D-serine, glycine, and beyond. Current Opinion in Pharmacology. 20: 109-15. PMID 25540902 DOI: 10.1016/J.Coph.2014.12.004  0.398
2015 Zhang S, Wang S, Puhl MD, Jiang X, Hyrc KL, Laciny E, Wallendorf MJ, Pappan KL, Coyle JT, Wice BM. Global biochemical profiling identifies β-hydroxypyruvate as a potential mediator of type 2 diabetes in mice and humans. Diabetes. 64: 1383-94. PMID 25368100 DOI: 10.2337/Db14-1188  0.734
2015 Puhl M, Donahue R, Landino S, Carlezon W, Coyle J. Modeling anhedonia in serine racemase knockout mice: Implications for co-morbid substance abuse and schizophrenia Drug and Alcohol Dependence. 156: e182. DOI: 10.1016/J.Drugalcdep.2015.07.677  0.753
2014 Puhl MD, Mintzopoulos D, Jensen JE, Gillis TE, Konopaske GT, Kaufman MJ, Coyle JT. In vivo magnetic resonance studies reveal neuroanatomical and neurochemical abnormalities in the serine racemase knockout mouse model of schizophrenia. Neurobiology of Disease. 73: 269-274. PMID 25461193 DOI: 10.1016/J.Nbd.2014.10.009  0.78
2014 Konopaske GT, Lange N, Coyle JT, Benes FM. Prefrontal cortical dendritic spine pathology in schizophrenia and bipolar disorder. Jama Psychiatry. 71: 1323-31. PMID 25271938 DOI: 10.1001/Jamapsychiatry.2014.1582  0.344
2014 Balu DT, Coyle JT. Chronic D-serine reverses arc expression and partially rescues dendritic abnormalities in a mouse model of NMDA receptor hypofunction. Neurochemistry International. 75: 76-8. PMID 24915645 DOI: 10.1016/J.Neuint.2014.05.015  0.415
2014 Balu DT, Takagi S, Puhl MD, Benneyworth MA, Coyle JT. D-serine and serine racemase are localized to neurons in the adult mouse and human forebrain. Cellular and Molecular Neurobiology. 34: 419-35. PMID 24436034 DOI: 10.1007/S10571-014-0027-Z  0.794
2014 Santini MA, Balu DT, Puhl MD, Hill-Smith TE, Berg AR, Lucki I, Mikkelsen JD, Coyle JT. D-serine deficiency attenuates the behavioral and cellular effects induced by the hallucinogenic 5-HT(2A) receptor agonist DOI. Behavioural Brain Research. 259: 242-6. PMID 24269270 DOI: 10.1016/J.Bbr.2013.11.022  0.779
2013 Balu DT, Li Y, Puhl MD, Benneyworth MA, Basu AC, Takagi S, Bolshakov VY, Coyle JT. Multiple risk pathways for schizophrenia converge in serine racemase knockout mice, a mouse model of NMDA receptor hypofunction. Proceedings of the National Academy of Sciences of the United States of America. 110: E2400-9. PMID 23729812 DOI: 10.1073/Pnas.1304308110  0.803
2013 Konopaske GT, Bolo NR, Basu AC, Renshaw PF, Coyle JT. Time-dependent effects of haloperidol on glutamine and GABA homeostasis and astrocyte activity in the rat brain. Psychopharmacology. 230: 57-67. PMID 23660600 DOI: 10.1007/S00213-013-3136-3  0.749
2013 Li Y, Sacchi S, Pollegioni L, Basu AC, Coyle JT, Bolshakov VY. Identity of endogenous NMDAR glycine site agonist in amygdala is determined by synaptic activity level. Nature Communications. 4: 1760. PMID 23612301 DOI: 10.1038/Ncomms2779  0.75
2012 Coyle JT, Basu A, Benneyworth M, Balu D, Konopaske G. Glutamatergic synaptic dysregulation in schizophrenia: therapeutic implications. Handbook of Experimental Pharmacology. 267-95. PMID 23027419 DOI: 10.1007/978-3-642-25758-2_10  0.808
2012 Coyle JT. NMDA receptor and schizophrenia: a brief history. Schizophrenia Bulletin. 38: 920-6. PMID 22987850 DOI: 10.1093/schbul/sbs076  0.414
2012 Benneyworth MA, Coyle JT. Altered acquisition and extinction of amphetamine-paired context conditioning in genetic mouse models of altered NMDA receptor function. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 2496-504. PMID 22763616 DOI: 10.1038/Npp.2012.108  0.752
2012 Balu DT, Coyle JT. Neuronal D-serine regulates dendritic architecture in the somatosensory cortex. Neuroscience Letters. 517: 77-81. PMID 22521586 DOI: 10.1016/J.Neulet.2012.04.020  0.401
2012 Benneyworth MA, Li Y, Basu AC, Bolshakov VY, Coyle JT. Cell selective conditional null mutations of serine racemase demonstrate a predominate localization in cortical glutamatergic neurons. Cellular and Molecular Neurobiology. 32: 613-24. PMID 22362148 DOI: 10.1007/S10571-012-9808-4  0.814
2012 Bergeron R, Coyle JT. NAAG, NMDA receptor and psychosis. Current Medicinal Chemistry. 19: 1360-4. PMID 22304714 DOI: 10.2174/092986712799462685  0.425
2012 Schaevitz LR, Picker JD, Rana J, Kolodny NH, Shane B, Berger-Sweeney JE, Coyle JT. Glutamate carboxypeptidase II and folate deficiencies result in reciprocal protection against cognitive and social deficits in mice: implications for neurodevelopmental disorders. Developmental Neurobiology. 72: 891-905. PMID 22076974 DOI: 10.1002/Dneu.21000  0.669
2012 Balu DT, Basu AC, Corradi JP, Cacace AM, Coyle JT. The NMDA receptor co-agonists, D-serine and glycine, regulate neuronal dendritic architecture in the somatosensory cortex. Neurobiology of Disease. 45: 671-82. PMID 22024716 DOI: 10.1016/J.Nbd.2011.10.006  0.784
2011 Sullivan SJ, Esguerra M, Wickham RJ, Romero GE, Coyle JT, Miller RF. Serine racemase deletion abolishes light-evoked NMDA receptor currents in retinal ganglion cells. The Journal of Physiology. 589: 5997-6006. PMID 22041185 DOI: 10.1113/Jphysiol.2011.217059  0.344
2011 Balu DT, Coyle JT. Glutamate receptor composition of the post-synaptic density is altered in genetic mouse models of NMDA receptor hypo- and hyperfunction. Brain Research. 1392: 1-7. PMID 21443867 DOI: 10.1016/J.Brainres.2011.03.051  0.396
2011 Benneyworth MA, Roseman AS, Basu AC, Coyle JT. Failure of NMDA receptor hypofunction to induce a pathological reduction in PV-positive GABAergic cell markers. Neuroscience Letters. 488: 267-71. PMID 21094213 DOI: 10.1016/J.Neulet.2010.11.043  0.808
2011 DeVito LM, Balu DT, Kanter BR, Lykken C, Basu AC, Coyle JT, Eichenbaum H. Serine racemase deletion disrupts memory for order and alters cortical dendritic morphology. Genes, Brain, and Behavior. 10: 210-22. PMID 21029376 DOI: 10.1111/J.1601-183X.2010.00656.X  0.771
2011 Balu DT, Coyle JT. Neuroplasticity signaling pathways linked to the pathophysiology of schizophrenia. Neuroscience and Biobehavioral Reviews. 35: 848-70. PMID 20951727 DOI: 10.1016/J.Neubiorev.2010.10.005  0.353
2011 Benneyworth MA, Basu AC, Coyle JT. Discordant behavioral effects of psychotomimetic drugs in mice with altered NMDA receptor function. Psychopharmacology. 213: 143-53. PMID 20865248 DOI: 10.1007/S00213-010-2023-4  0.813
2010 Coyle JT, Balu D, Benneyworth M, Basu A, Roseman A. Beyond the dopamine receptor: novel therapeutic targets for treating schizophrenia. Dialogues in Clinical Neuroscience. 12: 359-82. PMID 20954431  0.778
2010 Mustafa AK, Ahmad AS, Zeynalov E, Gazi SK, Sikka G, Ehmsen JT, Barrow RK, Coyle JT, Snyder SH, Doré S. Serine racemase deletion protects against cerebral ischemia and excitotoxicity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 1413-6. PMID 20107067 DOI: 10.1523/Jneurosci.4297-09.2010  0.567
2010 Basu AC, Tsai GE, Ma CL, Ehmsen JT, Mustafa AK, Han L, Jiang ZI, Benneyworth MA, Froimowitz MP, Lange N, Snyder SH, Bergeron R, Coyle JT. Targeted disruption of serine racemase affects glutamatergic neurotransmission and behavior (Molecular Psychiatry (2009) 14 (719-727) DOI: 10.1038/mp.2008.130) Molecular Psychiatry. 15: 1122. DOI: 10.1038/Mp.2010.84  0.759
2009 Reed BT, Sullivan SJ, Tsai G, Coyle JT, Esguerra M, Miller RF. The glycine transporter GlyT1 controls N-methyl-D-aspartic acid receptor coagonist occupancy in the mouse retina. The European Journal of Neuroscience. 30: 2308-17. PMID 20092573 DOI: 10.1111/J.1460-9568.2009.07020.X  0.381
2009 Biziere K, Coyle JT. Influence of cortico-striatal afferents on striatal kainic acid neurotoxicity. Neuroscience Letters. 8: 303-10. PMID 19605177 DOI: 10.1016/0304-3940(78)90140-4  0.354
2009 Ghose S, Chin R, Gallegos A, Roberts R, Coyle J, Tamminga C. Localization of NAAG-related gene expression deficits to the anterior hippocampus in schizophrenia Schizophrenia Research. 111: 131-137. PMID 19403271 DOI: 10.1016/J.Schres.2009.03.038  0.357
2009 Duggan PS, Siegel AW, Blass DM, Bok H, Coyle JT, Faden R, Finkel J, Gearhart JD, Greely HT, Hillis A, Hoke A, Johnson R, Johnston M, Kahn J, Kerr D, et al. Unintended changes in cognition, mood, and behavior arising from cell-based interventions for neurological conditions: ethical challenges. The American Journal of Bioethics : Ajob. 9: 31-6. PMID 19396681 DOI: 10.1080/15265160902788645  0.453
2009 Han L, Picker JD, Schaevitz LR, Tsai G, Feng J, Jiang Z, Chu HC, Basu AC, Berger-Sweeney J, Coyle JT. Phenotypic characterization of mice heterozygous for a null mutation of glutamate carboxypeptidase II. Synapse (New York, N.Y.). 63: 625-35. PMID 19347959 DOI: 10.1002/Syn.20649  0.804
2009 Coyle JT. MicroRNAs suggest a new mechanism for altered brain gene expression in schizophrenia. Proceedings of the National Academy of Sciences of the United States of America. 106: 2975-6. PMID 19251669 DOI: 10.1073/pnas.0813321106  0.341
2009 Basu AC, Tsai GE, Ma CL, Ehmsen JT, Mustafa AK, Han L, Jiang ZI, Benneyworth MA, Froimowitz MP, Lange N, Snyder SH, Bergeron R, Coyle JT. Targeted disruption of serine racemase affects glutamatergic neurotransmission and behavior. Molecular Psychiatry. 14: 719-27. PMID 19065142 DOI: 10.1038/Mp.2008.130  0.812
2009 Regenberg A, Mathews DJ, Blass DM, Bok H, Coyle JT, Duggan P, Faden R, Finkel J, Gearhart JD, Hillis A, Hoke A, Johnson R, Johnston M, Kahn J, Kerr D, et al. The role of animal models in evaluating reasonable safety and efficacy for human trials of cell-based interventions for neurologic conditions. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 29: 1-9. PMID 18728679 DOI: 10.1038/Jcbfm.2008.98  0.432
2008 Mathews DJ, Sugarman J, Bok H, Blass DM, Coyle JT, Duggan P, Finkel J, Greely HT, Hillis A, Hoke A, Johnson R, Johnston M, Kahn J, Kerr D, Kurtzberg J, et al. Cell-based interventions for neurologic conditions: ethical challenges for early human trials. Neurology. 71: 288-93. PMID 18463365 DOI: 10.1212/01.Wnl.0000316436.13659.80  0.417
2008 Lisman JE, Coyle JT, Green RW, Javitt DC, Benes FM, Heckers S, Grace AA. Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia. Trends in Neurosciences. 31: 234-42. PMID 18395805 DOI: 10.1016/J.Tins.2008.02.005  0.352
2007 Lawson-Yuen A, Liu D, Han L, Jiang ZI, Tsai GE, Basu AC, Picker J, Feng J, Coyle JT. Ube3a mRNA and protein expression are not decreased in Mecp2R168X mutant mice. Brain Research. 1180: 1-6. PMID 17936729 DOI: 10.1016/J.Brainres.2007.08.039  0.724
2007 Coyle JT, Geerts H, Sorra K, Amatniek J. Beyond in vitro data: a review of in vivo evidence regarding the allosteric potentiating effect of galantamine on nicotinic acetylcholine receptors in Alzheimer's neuropathology. Journal of Alzheimer's Disease : Jad. 11: 491-507. PMID 17656829 DOI: 10.3233/Jad-2007-11411  0.3
2007 Bergeron R, Imamura Y, Frangioni JV, Greene RW, Coyle JT. Endogenous N-acetylaspartylglutamate reduced NMDA receptor-dependent current neurotransmission in the CA1 area of the hippocampus. Journal of Neurochemistry. 100: 346-57. PMID 17241157 DOI: 10.1111/j.1471-4159.2006.04253.x  0.34
2007 Siekmeier PJ, Hasselmo ME, Howard MW, Coyle J. Modeling of context-dependent retrieval in hippocampal region CA1: implications for cognitive function in schizophrenia. Schizophrenia Research. 89: 177-90. PMID 17055702 DOI: 10.1016/J.Schres.2006.08.007  0.365
2007 Frye MA, Tsai GE, Huggins T, Coyle JT, Post RM. Low cerebrospinal fluid glutamate and glycine in refractory affective disorder. Biological Psychiatry. 61: 162-6. PMID 16735030 DOI: 10.1016/j.biopsych.2006.01.024  0.342
2006 Coyle JT. Substance use disorders and Schizophrenia: a question of shared glutamatergic mechanisms. Neurotoxicity Research. 10: 221-33. PMID 17197372 DOI: 10.1007/BF03033359  0.4
2006 Ross CA, Margolis RL, Reading SA, Pletnikov M, Coyle JT. Neurobiology of schizophrenia. Neuron. 52: 139-53. PMID 17015232 DOI: 10.1016/J.Neuron.2006.09.015  0.336
2006 Coyle JT. Glutamate and schizophrenia: beyond the dopamine hypothesis. Cellular and Molecular Neurobiology. 26: 365-84. PMID 16773445 DOI: 10.1007/s10571-006-9062-8  0.405
2005 Picker JD, Coyle JT. Do maternal folate and homocysteine levels play a role in neurodevelopmental processes that increase risk for schizophrenia? Harvard Review of Psychiatry. 13: 197-205. PMID 16126606 DOI: 10.1080/10673220500243372  0.322
2005 Yurgelun-Todd DA, Coyle JT, Gruber SA, Renshaw PF, Silveri MM, Amico E, Cohen B, Goff DC. Functional magnetic resonance imaging studies of schizophrenic patients during word production: effects of D-cycloserine. Psychiatry Research. 138: 23-31. PMID 15708298 DOI: 10.1016/J.Pscychresns.2004.11.006  0.309
2005 Martina M, B-Turcotte ME, Halman S, Tsai G, Tiberi M, Coyle JT, Bergeron R. Reduced glycine transporter type 1 expression leads to major changes in glutamatergic neurotransmission of CA1 hippocampal neurones in mice. The Journal of Physiology. 563: 777-93. PMID 15661817 DOI: 10.1113/jphysiol.2004.080655  0.369
2005 Bergeron R, Coyle JT, Tsai G, Greene RW. NAAG reduces NMDA receptor current in CA1 hippocampal pyramidal neurons of acute slices and dissociated neurons. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 30: 7-16. PMID 15354184 DOI: 10.1038/sj.npp.1300559  0.363
2004 Coyle JT. The GABA-glutamate connection in schizophrenia: which is the proximate cause? Biochemical Pharmacology. 68: 1507-14. PMID 15451393 DOI: 10.1016/j.bcp.2004.07.034  0.396
2004 Goff DC, Bottiglieri T, Arning E, Shih V, Freudenreich O, Evins AE, Henderson DC, Baer L, Coyle J. Folate, homocysteine, and negative symptoms in schizophrenia American Journal of Psychiatry. 161: 1705-1708. PMID 15337665 DOI: 10.1176/Appi.Ajp.161.9.1705  0.325
2004 Coyle JT, Tsai G. The NMDA receptor glycine modulatory site: a therapeutic target for improving cognition and reducing negative symptoms in schizophrenia. Psychopharmacology. 174: 32-8. PMID 15205876 DOI: 10.1007/s00213-003-1709-2  0.373
2004 Tsai G, Ralph-Williams RJ, Martina M, Bergeron R, Berger-Sweeney J, Dunham KS, Jiang Z, Caine SB, Coyle JT. Gene knockout of glycine transporter 1: characterization of the behavioral phenotype. Proceedings of the National Academy of Sciences of the United States of America. 101: 8485-90. PMID 15159536 DOI: 10.1073/pnas.0402662101  0.694
2004 Coyle JT, Tsai G. NMDA receptor function, neuroplasticity, and the pathophysiology of schizophrenia. International Review of Neurobiology. 59: 491-515. PMID 15006500 DOI: 10.1016/S0074-7742(04)59019-0  0.361
2004 Ghose S, Weickert CS, Colvin SM, Coyle JT, Herman MM, Hyde TM, Kleinman JE. Glutamate carboxypeptidase II gene expression in the human frontal and temporal lobe in schizophrenia. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 29: 117-25. PMID 14560319 DOI: 10.1038/Sj.Npp.1300304  0.37
2003 Coyle JT, Tsai G, Goff D. Converging evidence of NMDA receptor hypofunction in the pathophysiology of schizophrenia. Annals of the New York Academy of Sciences. 1003: 318-27. PMID 14684455 DOI: 10.1196/Annals.1300.020  0.384
2003 Tsai G, Dunham KS, Drager U, Grier A, Anderson C, Collura J, Coyle JT. Early embryonic death of glutamate carboxypeptidase II (NAALADase) homozygous mutants. Synapse (New York, N.Y.). 50: 285-92. PMID 14556233 DOI: 10.1002/syn.10263  0.336
2003 Flores C, Coyle JT. Regulation of glutamate carboxypeptidase II function in corticolimbic regions of rat brain by phencyclidine, haloperidol, and clozapine. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 28: 1227-34. PMID 12700705 DOI: 10.1038/sj.npp.1300129  0.387
2003 Ke Y, Coyle J, Simpson N, Gruber S, Renshaw P, Yurgelun-Todd D. Frontal brain NAA T2 values are significantly lower in schizophrenia Schizophrenia Research. 60: 242. DOI: 10.1016/S0920-9964(03)81247-1  0.306
2002 Coyle JT, Tsai G, Goff DC. Ionotropic glutamate receptors as therapeutic targets in schizophrenia. Current Drug Targets. Cns and Neurological Disorders. 1: 183-9. PMID 12769626 DOI: 10.2174/1568007024606212  0.409
2002 Tsai G, Coyle JT. Glutamatergic mechanisms in schizophrenia. Annual Review of Pharmacology and Toxicology. 42: 165-79. PMID 11807169 DOI: 10.1146/annurev.pharmtox.42.082701.160735  0.397
2001 Goff DC, Coyle JT. The emerging role of glutamate in the pathophysiology and treatment of schizophrenia. The American Journal of Psychiatry. 158: 1367-77. PMID 11532718 DOI: 10.1176/Appi.Ajp.158.9.1367  0.419
2000 Leveque JC, Macías W, Rajadhyaksha A, Carlson RR, Barczak A, Kang S, Li XM, Coyle JT, Huganir RL, Heckers S, Konradi C. Intracellular modulation of NMDA receptor function by antipsychotic drugs. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 4011-20. PMID 10818136 DOI: 10.1523/Jneurosci.20-11-04011.2000  0.343
2000 Nguyen TV, Brownell AL, Iris Chen YC, Livni E, Coyle JT, Rosen BR, Cavagna F, Jenkins BG. Detection of the effects of dopamine receptor supersensitivity using pharmacological MRI and correlations with PET. Synapse (New York, N.Y.). 36: 57-65. PMID 10700026 DOI: 10.1002/(SICI)1098-2396(200004)36:1<57::AID-SYN6>3.0.CO;2-K  0.333
2000 Coyle JT, Schwarcz R. Mind glue: implications of glial cell biology for psychiatry. Archives of General Psychiatry. 57: 90-3. PMID 10632240 DOI: 10.1001/Archpsyc.57.1.90  0.31
1999 Tsai GE, Yang P, Chung LC, Tsai IC, Tsai CW, Coyle JT. D-serine added to clozapine for the treatment of schizophrenia. The American Journal of Psychiatry. 156: 1822-5. PMID 10553752 DOI: 10.1176/Ajp.156.11.1822  0.347
1999 Berger UV, Luthi-Carter R, Passani LA, Elkabes S, Black I, Konradi C, Coyle JT. Glutamate carboxypeptidase II is expressed by astrocytes in the adult rat nervous system. The Journal of Comparative Neurology. 415: 52-64. PMID 10540357 DOI: 10.1002/(Sici)1096-9861(19991206)415:1<52::Aid-Cne4>3.0.Co;2-K  0.55
1999 Goff DC, Tsai G, Levitt J, Amico E, Manoach D, Schoenfeld DA, Hayden DL, McCarley R, Coyle JT. A placebo-controlled trial of D-cycloserine added to conventional neuroleptics in patients with schizophrenia. Archives of General Psychiatry. 56: 21-7. PMID 9892252 DOI: 10.1001/Archpsyc.56.1.21  0.341
1998 Bergeron R, Meyer TM, Coyle JT, Greene RW. Modulation of N-methyl-D-aspartate receptor function by glycine transport. Proceedings of the National Academy of Sciences of the United States of America. 95: 15730-4. PMID 9861038 DOI: 10.1073/pnas.95.26.15730  0.37
1998 Tsai G, Yang P, Chung LC, Lange N, Coyle JT. D-serine added to antipsychotics for the treatment of schizophrenia. Biological Psychiatry. 44: 1081-9. PMID 9836012 DOI: 10.1016/S0006-3223(98)00279-0  0.38
1998 Tsai G, van Kammen DP, Chen S, Kelley ME, Grier A, Coyle JT. Glutamatergic neurotransmission involves structural and clinical deficits of schizophrenia. Biological Psychiatry. 44: 667-74. PMID 9798069 DOI: 10.1016/S0006-3223(98)00151-6  0.378
1998 Tsai G, Goff DC, Chang RW, Flood J, Baer L, Coyle JT. Markers of glutamatergic neurotransmission and oxidative stress associated with tardive dyskinesia. The American Journal of Psychiatry. 155: 1207-13. PMID 9734544 DOI: 10.1176/Ajp.155.9.1207  0.331
1998 Corsi P, Forloni G, Troia M, Lettini T, Coyle JT. Somatostatin expression in TS16 mouse brain cultures. Journal of Molecular Neuroscience : Mn. 10: 99-111. PMID 9699151 DOI: 10.1007/BF02737121  0.304
1998 Schwartz PJ, Coyle JT. Effects of overexpression of the cytoplasmic copper-zinc superoxide dismutase on the survival of neurons in vitro. Synapse (New York, N.Y.). 29: 206-12. PMID 9635890 DOI: 10.1002/(Sici)1098-2396(199807)29:3<206::Aid-Syn2>3.0.Co;2-A  0.499
1998 Schwartz PJ, Reaume A, Scott R, Coyle JT. Effects of over- and under-expression of Cu,Zn-superoxide dismutase on the toxicity of glutamate analogs in transgenic mouse striatum. Brain Research. 789: 32-9. PMID 9602043 DOI: 10.1016/S0006-8993(97)01469-8  0.553
1998 Tsai G, Coyle JT. The role of glutamatergic neurotransmission in the pathophysiology of alcoholism. Annual Review of Medicine. 49: 173-84. PMID 9509257 DOI: 10.1146/  0.341
1998 Luthi-Carter R, Berger UV, Barczak AK, Enna M, Coyle JT. Isolation and expression of a rat brain cDNA encoding glutamate carboxypeptidase II. Proceedings of the National Academy of Sciences of the United States of America. 95: 3215-20. PMID 9501243 DOI: 10.1073/pnas.95.6.3215  0.313
1998 van Kammen D, Kelley M, Yao J, Tsai G, Coyle J. 276. The role of glutamate and HVA in schizophrenic symptomatology Biological Psychiatry. 43: S83. DOI: 10.1016/S0006-3223(98)90724-7  0.323
1997 Passani LA, Vonsattel JP, Coyle JT. Distribution of N-acetylaspartylglutamate immunoreactivity in human brain and its alteration in neurodegenerative disease. Brain Research. 772: 9-22. PMID 9406950 DOI: 10.1016/S0006-8993(97)00784-1  0.369
1997 Orlando LR, Luthi-Carter R, Standaert DG, Coyle JT, Penney JB, Young AB. N-acetylaspartylglutamate (NAAG) protects against rat striatal quinolinic acid lesions in vivo. Neuroscience Letters. 236: 91-4. PMID 9404819 DOI: 10.1016/S0304-3940(97)00769-6  0.351
1997 Passani LA, Vonsattel JP, Carter RE, Coyle JT. N-acetylaspartylglutamate, N-acetylaspartate, and N-acetylated alpha-linked acidic dipeptidase in human brain and their alterations in Huntington and Alzheimer's diseases. Molecular and Chemical Neuropathology / Sponsored by the International Society For Neurochemistry and the World Federation of Neurology and Research Groups On Neurochemistry and Cerebrospinal Fluid. 31: 97-118. PMID 9376025 DOI: 10.1007/BF02815236  0.355
1997 Coyle JT. The nagging question of the function of N-acetylaspartylglutamate. Neurobiology of Disease. 4: 231-8. PMID 9361299 DOI: 10.1006/nbdi.1997.0153  0.376
1996 Coyle JT. The glutamatergic dysfunction hypothesis for schizophrenia. Harvard Review of Psychiatry. 3: 241-53. PMID 9384954 DOI: 10.3109/10673229609017192  0.422
1996 Goff DC, Tsai G, Manoach DS, Flood J, Darby DG, Coyle JT. D-cycloserine added to clozapine for patients with schizophrenia. The American Journal of Psychiatry. 153: 1628-30. PMID 8942463 DOI: 10.1176/Ajp.153.12.1628  0.311
1996 Simonian NA, Getz RL, Leveque JC, Konradi C, Coyle JT. Kainic acid induces apoptosis in neurons. Neuroscience. 75: 1047-55. PMID 8938740 DOI: 10.1016/0306-4522(96)00326-0  0.324
1996 Simonian NA, Getz RL, Leveque JC, Konradi C, Coyle JT. Kainate induces apoptosis in neurons. Neuroscience. 74: 675-83. PMID 8884764 DOI: 10.1016/0306-4522(96)00141-8  0.333
1995 Guimaraes AR, Schwartz P, Prakash MR, Carr CA, Berger UV, Jenkins BG, Coyle JT, González RG. Quantitative in vivo 1H nuclear magnetic resonance spectroscopic imaging of neuronal loss in rat brain. Neuroscience. 69: 1095-1101. PMID 8848098 DOI: 10.1016/0306-4522(95)00300-8  0.534
1995 Tsai G, Coyle JT. N-acetylaspartate in neuropsychiatric disorders. Progress in Neurobiology. 46: 531-40. PMID 8532851 DOI: 10.1016/0301-0082(95)00014-M  0.324
1995 Berger UV, Carter RE, Coyle JT. The immunocytochemical localization of N-acetylaspartyl glutamate, its hydrolysing enzyme NAALADase, and the NMDAR-1 receptor at a vertebrate neuromuscular junction. Neuroscience. 64: 847-50. PMID 7753384 DOI: 10.1016/0306-4522(95)92578-8  0.36
1995 Goff DC, Tsai G, Manoach DS, Coyle JT. Dose-finding trial of D-cycloserine added to neuroleptics for negative symptoms in schizophrenia. The American Journal of Psychiatry. 152: 1213-5. PMID 7625475 DOI: 10.1176/Ajp.152.8.1213  0.339
1995 Schwartz PJ, Berger UV, Coyle JT. Mice transgenic for copper/zinc superoxide dismutase exhibit increased markers of biogenic amine function. Journal of Neurochemistry. 65: 660-9. PMID 7616222 DOI: 10.1046/J.1471-4159.1995.65020660.X  0.54
1995 Tsai G, Passani LA, Slusher BS, Carter R, Baer L, Kleinman JE, Coyle JT. Abnormal excitatory neurotransmitter metabolism in schizophrenic brains. Archives of General Psychiatry. 52: 829-36. PMID 7575102 DOI: 10.1001/archpsyc.1995.03950220039008  0.431
1994 Vornov JJ, Tasker RC, Coyle JT. Delayed protection by MK-801 and tetrodotoxin in a rat organotypic hippocampal culture model of ischemia. Stroke; a Journal of Cerebral Circulation. 25: 457-64; discussion 4. PMID 8303757 DOI: 10.1161/01.Str.25.2.457  0.324
1994 Kitt CA, Höhmann C, Coyle JT, Price DL. Cholinergic innervation of mouse forebrain structures. The Journal of Comparative Neurology. 341: 117-29. PMID 8006218 DOI: 10.1002/cne.903410110  0.321
1994 Bachman ES, Berger-Sweeney J, Coyle JT, Hohmann CF. Developmental regulation of adult cortical morphology and behavior: an animal model for mental retardation. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. 12: 239-53. PMID 7976481 DOI: 10.1016/0736-5748(94)90071-X  0.787
1993 Tsai G, Cork LC, Slusher BS, Price D, Coyle JT. Abnormal acidic amino acids and N-acetylaspartylglutamate in hereditary canine motoneuron disease. Brain Research. 629: 305-9. PMID 8111634 DOI: 10.1016/0006-8993(93)91335-P  0.316
1993 Tsai G, Slusher BS, Sim L, Coyle JT. Immunocytochemical distribution of N-acetylaspartylglutamate in the rat forebrain and glutamatergic pathways. Journal of Chemical Neuroanatomy. 6: 277-92. PMID 7903856 DOI: 10.1016/0891-0618(93)90033-Z  0.339
1993 Coyle JT, Puttfarcken P. Oxidative stress, glutamate, and neurodegenerative disorders. Science (New York, N.Y.). 262: 689-95. PMID 7901908 DOI: 10.1126/Science.7901908  0.342
1992 Slusher BS, Tsai G, Yoo G, Coyle JT. Immunocytochemical localization of the N-acetyl-aspartyl-glutamate (NAAG) hydrolyzing enzyme N-acetylated alpha-linked acidic dipeptidase (NAALADase). The Journal of Comparative Neurology. 315: 217-29. PMID 1545010 DOI: 10.1002/cne.903150208  0.34
1992 Robinson MB, Anegawa NJ, Gorry E, Qureshi IA, Coyle JT, Lucki I, Batshaw ML. Brain serotonin2 and serotonin1A receptors are altered in the congenitally hyperammonemic sparse fur mouse. Journal of Neurochemistry. 58: 1016-22. PMID 1531355 DOI: 10.1111/J.1471-4159.1992.Tb09356.X  0.342
1992 Meyerhoff JL, Carter RE, Yourick DL, Slusher BS, Coyle JT. Genetically epilepsy-prone rats have increased brain regional activity of an enzyme which liberates glutamate from N-acetyl-aspartyl-glutamate. Brain Research. 593: 140-3. PMID 1360862 DOI: 10.1016/0006-8993(92)91276-K  0.35
1992 Tasker RC, Coyle JT, Vornov JJ. The regional vulnerability to hypoglycemia-induced neurotoxicity in organotypic hippocampal culture: protection by early tetrodotoxin or delayed MK-801. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 12: 4298-308. PMID 1359034 DOI: 10.1523/Jneurosci.12-11-04298.1992  0.328
1992 Puttfarcken PS, Lyons WE, Coyle JT. Dissociation of nitric oxide generation and kainate-mediated neuronal degeneration in primary cultures of rat cerebellar granule cells. Neuropharmacology. 31: 565-75. PMID 1328917 DOI: 10.1016/0028-3908(92)90189-V  0.331
1992 Hohmann CF, Capone GT, Coyle JT. Effects of Gene Imbalance on Amyloid Precursor Protein [APP] Expression in Grafts and Recipient Cortex Journal of Neural Transplantation and Plasticity. 3: 328-329. DOI: 10.1155/NP.1992.328  0.65
1991 Corsi P, Coyle JT. Nerve growth factor corrects developmental impairments of basal forebrain cholinergic neurons in the trisomy 16 mouse. Proceedings of the National Academy of Sciences of the United States of America. 88: 1793-7. PMID 2000385 DOI: 10.1073/Pnas.88.5.1793  0.301
1991 Capone GT, Bendotti C, Oster-Granite ML, Coyle JT. Developmental expression of the gene encoding growth-associated protein 43 (Gap43) in the brains of normal and aneuploid mice. Journal of Neuroscience Research. 29: 449-60. PMID 1838777 DOI: 10.1002/jnr.490290405  0.322
1991 Coyle JT, Oster-Granite ML, Reeves R, Hohmann C, Corsi P, Gearhart J. Down syndrome and the trisomy 16 mouse: impact of gene imbalance on brain development and aging. Research Publications - Association For Research in Nervous and Mental Disease. 69: 85-99. PMID 1825889  0.62
1991 Simmons ML, Frondoza CG, Coyle JT. Immunocytochemical localization of N-acetyl-aspartate with monoclonal antibodies. Neuroscience. 45: 37-45. PMID 1754068 DOI: 10.1016/0306-4522(91)90101-S  0.345
1991 McKinney M, Coyle JT. The potential for muscarinic receptor subtype-specific pharmacotherapy for Alzheimer's disease. Mayo Clinic Proceedings. 66: 1225-37. PMID 1749291 DOI: 10.1016/S0025-6196(12)62474-4  0.347
1991 Höhmann CF, Wilson L, Coyle JT. Efferent and afferent connections of mouse sensory-motor cortex following cholinergic deafferentation at birth. Cerebral Cortex (New York, N.Y. : 1991). 1: 158-72. PMID 1726604 DOI: 10.1093/Cercor/1.2.158  0.308
1991 Höhmann CF, Kwiterovich KK, Oster-Granite ML, Coyle JT. Newborn basal forebrain lesions disrupt cortical cytodifferentiation as visualized by rapid Golgi staining. Cerebral Cortex (New York, N.Y. : 1991). 1: 143-57. PMID 1726603 DOI: 10.1093/Cercor/1.2.143  0.351
1991 Vornov JJ, Tasker RC, Coyle JT. Direct observation of the agonist-specific regional vulnerability to glutamate, NMDA, and kainate neurotoxicity in organotypic hippocampal cultures. Experimental Neurology. 114: 11-22. PMID 1717307 DOI: 10.1016/0014-4886(91)90079-R  0.358
1991 Murphy TH, De Long MJ, Coyle JT. Enhanced NAD(P)H:quinone reductase activity prevents glutamate toxicity produced by oxidative stress. Journal of Neurochemistry. 56: 990-5. PMID 1704427 DOI: 10.1111/J.1471-4159.1991.Tb02019.X  0.315
1991 Coyle JT, Murphy TH, Puttfarcken PS, Lyons EW, Vornov JJ. The non-excitatory mechanisms of glutamate induced neurotoxicity. Epilepsy Research. 10: 41-8. PMID 1686428 DOI: 10.1016/0920-1211(91)90093-U  0.304
1991 Tsai GC, Stauch-Slusher B, Sim L, Hedreen JC, Rothstein JD, Kuncl R, Coyle JT. Reductions in acidic amino acids and N-acetylaspartylglutamate in amyotrophic lateral sclerosis CNS. Brain Research. 556: 151-6. PMID 1682006 DOI: 10.1016/0006-8993(91)90560-I  0.331
1991 Vornov JJ, Coyle JT. Glutamate neurotoxicity and the inhibition of protein synthesis in the hippocampal slice. Journal of Neurochemistry. 56: 996-1006. PMID 1671589 DOI: 10.1111/J.1471-4159.1991.Tb02020.X  0.374
1991 Vornov JJ, Coyle JT. Enhancement of NMDA receptor-mediated neurotoxicity in the hippocampal slice by depolarization and ischemia. Brain Research. 555: 99-106. PMID 1657299 DOI: 10.1016/0006-8993(91)90865-S  0.362
1990 Rothstein JD, Tsai G, Kuncl RW, Clawson L, Cornblath DR, Drachman DB, Pestronk A, Stauch BL, Coyle JT. Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis. Annals of Neurology. 28: 18-25. PMID 2375630 DOI: 10.1002/ana.410280106  0.323
1990 Lowenstein PR, Joyce JN, Coyle JT, Marshall JF. Striosomal organization of cholinergic and dopaminergic uptake sites and cholinergic M1 receptors in the adult human striatum: a quantitative receptor autoradiographic study. Brain Research. 510: 122-6. PMID 2322836 DOI: 10.1016/0006-8993(90)90736-U  0.302
1990 Frondoza CG, Logan S, Forloni G, Coyle JT. Production and characterization of monoclonal antibodies to N-acetyl-aspartyl-glutamate. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 38: 493-502. PMID 2319120 DOI: 10.1177/38.4.2319120  0.337
1990 Murphy TH, Schnaar RL, Coyle JT. Immature cortical neurons are uniquely sensitive to glutamate toxicity by inhibition of cystine uptake. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 4: 1624-33. PMID 2180770 DOI: 10.1096/Fasebj.4.6.2180770  0.369
1990 Höhmann CF, Capone G, Oster-Granite ML, Coyle JT. Transplantation of brain tissue from murine trisomy 16 into euploid hosts: effects of gene imbalance on brain development. Progress in Brain Research. 82: 203-14. PMID 2149768 DOI: 10.1016/S0079-6123(08)62606-0  0.329
1990 Miyamoto M, Coyle JT. Idebenone attenuates neuronal degeneration induced by intrastriatal injection of excitotoxins. Experimental Neurology. 108: 38-45. PMID 2138566 DOI: 10.1016/0014-4886(90)90005-D  0.389
1990 Forloni G, Hohmann C, Coyle JT. Developmental expression of somatostatin in mouse brain. I. Immunocytochemical studies. Brain Research. Developmental Brain Research. 53: 6-25. PMID 1972042 DOI: 10.1016/0165-3806(90)90120-N  0.701
1990 Bendotti C, Hohmann C, Forloni G, Reeves R, Coyle JT, Oster-Granite ML. Developmental expression of somatostatin in mouse brain. II. In situ hybridization. Brain Research. Developmental Brain Research. 53: 26-39. PMID 1972040 DOI: 10.1016/0165-3806(90)90121-E  0.698
1990 Caserta MT, Corsi P, Oster-Granite ML, Coyle JT. Increased number of somatostatin-immunoreactive neurons in primary cultures of trisomy 16 mouse neocortex. Brain Research. Molecular Brain Research. 7: 269-72. PMID 1970846 DOI: 10.1016/0169-328X(90)90037-E  0.34
1989 Lowenstein PR, Slesinger PA, Singer HS, Walker LC, Casanova MF, Raskin LS, Price DL, Coyle JT. Compartment-specific changes in the density of choline and dopamine uptake sites and muscarinic and dopaminergic receptors during the development of the baboon striatum: a quantitative receptor autoradiographic study. The Journal of Comparative Neurology. 288: 428-46. PMID 2794143 DOI: 10.1002/Cne.902880306  0.306
1989 Forloni G, Blake K, Hohmann CH, Coyle JT. The postnatal expression of acetylcholinesterase in somatostatin-positive cells of mouse hippocampus. Brain Research. Developmental Brain Research. 48: 73-85. PMID 2752576 DOI: 10.1016/0165-3806(89)90094-1  0.33
1989 Sweeney JE, Puttfarcken PS, Coyle JT. Galanthamine, an acetylcholinesterase inhibitor: a time course of the effects on performance and neurochemical parameters in mice. Pharmacology, Biochemistry, and Behavior. 34: 129-37. PMID 2626444 DOI: 10.1016/0091-3057(89)90364-X  0.338
1989 Meyerhoff JL, Robinson MB, Bixler MA, Richards SS, Coyle JT. Seizures decrease regional enzymatic hydrolysis of N-acetyl-aspartylglutamate in rat brain. Brain Research. 505: 130-4. PMID 2611666 DOI: 10.1016/0006-8993(89)90123-6  0.303
1989 Murphy TH, Miyamoto M, Sastre A, Schnaar RL, Coyle JT. Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress. Neuron. 2: 1547-58. PMID 2576375 DOI: 10.1016/0896-6273(89)90043-3  0.349
1989 Ma W, Höhmann CF, Coyle JT, Juliano SL. Lesions of the basal forebrain alter stimulus-evoked metabolic activity in mouse somatosensory cortex. The Journal of Comparative Neurology. 288: 414-27. PMID 2551936 DOI: 10.1002/cne.902880305  0.68
1989 Sweeney JE, Höhmann CF, Oster-Granite ML, Coyle JT. Neurogenesis of the basal forebrain in euploid and trisomy 16 mice: an animal model for developmental disorders in Down syndrome. Neuroscience. 31: 413-25. PMID 2529451 DOI: 10.1016/0306-4522(89)90384-9  0.341
1988 Guarda AS, Robinson MB, Ory-Lavollée L, Forloni GL, Blakely RD, Coyle JT. Quantitation of N-acetyl-aspartyl-glutamate in microdissected rat brain nuclei and peripheral tissues: findings with a novel liquid phase radioimmunoassay. Brain Research. 427: 223-31. PMID 3401700 DOI: 10.1016/0169-328X(88)90045-9  0.508
1988 Robertson RT, Höhmann CF, Bruce JL, Coyle JT. Neonatal enucleations reduce specific activity of acetylcholinesterase but not choline acetyltransferase in developing rat visual cortex. Brain Research. 467: 298-302. PMID 3378178 DOI: 10.1016/0165-3806(88)90034-X  0.675
1988 Blakely RD, Robinson MB, Thompson RC, Coyle JT. Hydrolysis of the brain dipeptide N-acetyl-L-aspartyl-L-glutamate: subcellular and regional distribution, ontogeny, and the effect of lesions on N-acetylated-alpha-linked acidic dipeptidase activity. Journal of Neurochemistry. 50: 1200-9. PMID 3346674 DOI: 10.1111/J.1471-4159.1988.Tb10593.X  0.543
1988 Höhmann CF, Coyle JT. Long-term effects of basal forebrain lesions on cholinergic, noradrenergic and serotonergic markers in mouse neocortex. Brain Research Bulletin. 21: 13-20. PMID 3219596 DOI: 10.1016/0361-9230(88)90113-X  0.331
1988 Hohmann CF, Brooks AR, Coyle JT. Neonatal lesions of the basal forebrain cholinergic neurons result in abnormal cortical development. Brain Research. 470: 253-64. PMID 3219585 DOI: 10.1016/0165-3806(88)90244-1  0.68
1988 Blakely RD, Coyle JT. The neurobiology of N-acetylaspartylglutamate. International Review of Neurobiology. 30: 39-100. PMID 3061970 DOI: 10.1016/S0074-7742(08)60046-X  0.543
1988 Murphy TH, Schnaar RL, Coyle JT, Sastre A. Glutamate cytotoxicity in a neuronal cell line is blocked by membrane depolarization. Brain Research. 460: 155-60. PMID 2905921 DOI: 10.1016/0006-8993(88)91216-4  0.32
1988 Bendotti C, Forloni GL, Morgan RA, O'Hara BF, Oster-Granite ML, Reeves RH, Gearhart JD, Coyle JT. Neuroanatomical localization and quantification of amyloid precursor protein mRNA by in situ hybridization in the brains of normal, aneuploid, and lesioned mice. Proceedings of the National Academy of Sciences of the United States of America. 85: 3628-32. PMID 2897124 DOI: 10.1073/Pnas.85.10.3628  0.321
1988 Murphy TH, Malouf AT, Sastre A, Schnaar RL, Coyle JT. Calcium-dependent glutamate cytotoxicity in a neuronal cell line. Brain Research. 444: 325-32. PMID 2896063 DOI: 10.1016/0006-8993(88)90941-9  0.318
1988 Blakely RD, Robinson MB, Guarda AS, Coyle JT. A re-examination of the interaction of N-acetyl-L-aspartyl-L-glutamate with a subpopulation of rat brain membrane L-[3H]glutamate binding sites. European Journal of Pharmacology. 151: 419-26. PMID 2850921 DOI: 10.1016/0014-2999(88)90538-9  0.532
1988 Hohmann CF, Hamon R, Batshaw ML, Coyle JT. Transient postnatal elevation of serotonin levels in mouse neocortex. Brain Research. 471: 163-6. PMID 2464412 DOI: 10.1016/0165-3806(88)90163-0  0.657
1987 Hohmann GF, Wenk GL, Lowenstein P, Brown ME, Coyle JT. Age-related recurrence of basal forebrain lesion-induced cholinergic deficits. Neuroscience Letters. 82: 253-9. PMID 3696497 DOI: 10.1016/0304-3940(87)90265-5  0.32
1987 Blakely RD, Ory-Lavollée L, Coyle JT. Specific alterations in the levels of N-acetyl-aspartyl-glutamate in the nervous system of the dystrophic mouse. Neuroscience Letters. 79: 223-8. PMID 3670731 DOI: 10.1016/0304-3940(87)90701-4  0.524
1987 Robinson MB, Blakely RD, Couto R, Coyle JT. Hydrolysis of the brain dipeptide N-acetyl-L-aspartyl-L-glutamate. Identification and characterization of a novel N-acetylated alpha-linked acidic dipeptidase activity from rat brain. The Journal of Biological Chemistry. 262: 14498-506. PMID 3667587  0.457
1987 Ory-Lavollée L, Blakely RD, Coyle JT. Neurochemical and immunocytochemical studies on the distribution of N-acetyl-aspartylglutamate and N-acetyl-aspartate in rat spinal cord and some peripheral nervous tissues. Journal of Neurochemistry. 48: 895-9. PMID 3543223 DOI: 10.1111/J.1471-4159.1987.Tb05601.X  0.488
1987 Forloni G, Grzanna R, Blakely RD, Coyle JT. Co-localization of N-acetyl-aspartyl-glutamate in central cholinergic, noradrenergic, and serotonergic neurons. Synapse (New York, N.Y.). 1: 455-60. PMID 3505373 DOI: 10.1002/syn.890010509  0.541
1987 Saltarelli MD, Forloni GL, Oster-Granite ML, Gearhart JD, Coyle JT. Neurochemical characterization of embryonic brain development in trisomy 19 (Ts19) mice: implications of selective deficits observed for abnormal neural development in aneuploidy. Developmental Genetics. 8: 267-79. PMID 2901927 DOI: 10.1002/Dvg.1020080409  0.39
1987 Zaczek R, Balm M, Arlis S, Drucker H, Coyle JT. Quisqualate-sensitive, chloride-dependent transport of glutamate into rat brain synaptosomes. Journal of Neuroscience Research. 18: 425-31. PMID 2893837 DOI: 10.1002/jnr.490180307  0.345
1987 Robinson MB, Coyle JT. Glutamate and related acidic excitatory neurotransmitters: from basic science to clinical application. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 1: 446-55. PMID 2890549 DOI: 10.1096/Fasebj.1.6.2890549  0.356
1987 Zaczek R, Arlis S, Markl A, Murphy T, Drucker H, Coyle JT. Characteristics of chloride-dependent incorporation of glutamate into brain membranes argue against a receptor binding site. Neuropharmacology. 26: 281-7. PMID 2884589 DOI: 10.1016/0028-3908(87)90179-1  0.314
1987 Blakely RD, Ory-Lavollée L, Grzanna R, Koller KJ, Coyle JT. Selective immunocytochemical staining of mitral cells in rat olfactory bulb with affinity purified antibodies against N-acetyl-aspartyl-glutamate. Brain Research. 402: 373-8. PMID 2435366 DOI: 10.1016/0006-8993(87)90049-7  0.524
1986 Batshaw ML, Hyman SL, Mellits ED, Thomas GH, DeMuro R, Coyle JT. Behavioral and neurotransmitter changes in the urease-infused rat: a model of congenital hyperammonemia. Pediatric Research. 20: 1310-5. PMID 3797124 DOI: 10.1203/00006450-198612000-00025  0.321
1986 Robinson MB, Blakely RD, Coyle JT. Quisqualate selectively inhibits a brain peptidase which cleaves N-acetyl-L-aspartyl-L-glutamate in vitro. European Journal of Pharmacology. 130: 345-7. PMID 3539626 DOI: 10.1016/0014-2999(86)90291-8  0.492
1986 Coyle JT, Blakely R, Zaczek R, Koller KJ, Abreu M, Ory-Lavollée L, Fisher R, ffrench-Mullen JM, Carpenter DO. Acidic peptides in brain: do they act at putative glutamatergic synapses? Advances in Experimental Medicine and Biology. 203: 375-84. PMID 2878566 DOI: 10.1007/978-1-4684-7971-3_28  0.524
1986 ffrench-Mullen JM, Murphy TH, Coyle JT, Fisher RS. Dicarboxylic amino acids block epileptiform activity in hippocampal slice. Epilepsia. 27: 678-84. PMID 2877868 DOI: 10.1111/J.1528-1157.1986.Tb03595.X  0.309
1986 Ferkany J, Coyle JT. Heterogeneity of sodium-dependent excitatory amino acid uptake mechanisms in rat brain. Journal of Neuroscience Research. 16: 491-503. PMID 2877096 DOI: 10.1002/jnr.490160305  0.324
1986 Coyle JT, Oster-Granite ML, Gearhart JD. The neurobiologic consequences of Down syndrome. Brain Research Bulletin. 16: 773-87. PMID 2875770 DOI: 10.1016/0361-9230(86)90074-2  0.334
1986 Blakely RD, Ory-Lavollée L, Thompson RC, Coyle JT. Synaptosomal transport of radiolabel from N-acetyl-aspartyl-[3H]glutamate suggests a mechanism of inactivation of an excitatory neuropeptide. Journal of Neurochemistry. 47: 1013-9. PMID 2875126 DOI: 10.1111/J.1471-4159.1986.Tb00714.X  0.528
1986 Campochiaro P, Ferkany JW, Coyle JT. Excitatory amino acid analogs evoke release of endogenous amino acids and acetyl choline from chick retina in vitro. Vision Research. 25: 1375-86. PMID 2868567 DOI: 10.1016/0042-6989(85)90215-9  0.311
1986 Struble RG, Lehmann J, Mitchell SJ, McKinney M, Price DL, Coyle JT, DeLong MR. Basal forebrain neurons provide major cholinergic innervation of primate neocortex. Neuroscience Letters. 66: 215-20. PMID 2425286 DOI: 10.1016/0304-3940(86)90193-X  0.324
1985 Coyle JT, Singer H, McKinney M, Price D. Neurotransmitter specific alterations in dementing disorders: insights from animal models. Journal of Psychiatric Research. 18: 501-12. PMID 6150995 DOI: 10.1016/0022-3956(84)90037-2  0.312
1985 Koller KJ, Coyle JT. Specific labelling of brain receptors with [3H]N-acetyl-aspartyl-glutamate. European Journal of Pharmacology. 104: 193-4. PMID 6094210 DOI: 10.1016/0014-2999(84)90392-3  0.334
1985 Sanberg PR, Pevsner J, Autuono PG, Coyle JT. Fetal methylazoxymethanol acetate-induced lesions cause reductions in dopamine receptor-mediated catalepsy and stereotypy. Neuropharmacology. 24: 1057-62. PMID 4080104 DOI: 10.1016/0028-3908(85)90191-1  0.341
1985 Sandberg K, Coyle JT. Characterization of [3H]hemicholinium-3 binding associated with neuronal choline uptake sites in rat brain membranes. Brain Research. 348: 321-30. PMID 4075090 DOI: 10.1016/0006-8993(85)90451-2  0.322
1985 Meyerhoff JL, Koller KJ, Walczak DD, Coyle JT. Regional brain levels of N-acetyl-aspartyl-glutamate: the effect of kindled seizures. Brain Research. 346: 392-6. PMID 4052789 DOI: 10.1016/0006-8993(85)90877-7  0.315
1985 Ffrench-Mullen JM, Koller K, Zaczek R, Coyle JT, Hori N, Carpenter DO. N-Acetylaspartylglutamate: possible role as the neurotransmitter of the lateral olfactory tract. Proceedings of the National Academy of Sciences of the United States of America. 82: 3897-900. PMID 2860670 DOI: 10.1073/Pnas.82.11.3897  0.335
1985 Foster GA, Hökfelt T, Coyle JT, Goldstein M. Immunohistochemical evidence for phenylethanolamine-N-methyltransferase-positive/tyrosine hydroxylase-negative neurones in the retina and the posterior hypothalamus of the rat Brain Research. 330: 183-188. PMID 2859084 DOI: 10.1016/0006-8993(85)90025-3  0.313
1985 Bernstein J, Fisher R, Zaczek R, Coyle J. Dipeptides of glutamate and aspartate may be endogenous neuroexcitants in the rat hippocampal slice The Journal of Neuroscience. 5: 1429-1433. DOI: 10.1523/Jneurosci.05-06-01429.1985  0.336
1984 Ayd FJ, Coyle JT, Hollister LE, Simpson GM. Tardive Dyskinesia and Thioridazine Archives of General Psychiatry. 41: 414-415. PMID 6703859 DOI: 10.1001/Archpsyc.1984.01790150104015  0.3
1984 Sandberg K, Sanberg PR, Hanin I, Fisher A, Coyle JT. Cholinergic lesion of the striatum impairs acquisition and retention of a passive avoidance response. Behavioral Neuroscience. 98: 162-5. PMID 6546518 DOI: 10.1037//0735-7044.98.1.162  0.339
1984 London ED, McKinney M, Dam M, Ellis A, Coyle JT. Decreased cortical glucose utilization after ibotenate lesion of the rat ventromedial globus pallidus Journal of Cerebral Blood Flow and Metabolism. 4: 381-390. PMID 6540786 DOI: 10.1038/Jcbfm.1984.56  0.306
1984 Tiemeyer MJ, Singer HS, Troncoso JC, Cork LC, Coyle JT, Price DL. Synaptic neurochemical alterations associated with neuronal degeneration in an inherited cerebellar ataxia of Gordon Setters. Journal of Neuropathology and Experimental Neurology. 43: 580-91. PMID 6502189 DOI: 10.1097/00005072-198411000-00003  0.352
1984 Koller KJ, Zaczek R, Coyle JT. N-acetyl-aspartyl-glutamate: regional levels in rat brain and the effects of brain lesions as determined by a new HPLC method. Journal of Neurochemistry. 43: 1136-42. PMID 6470709 DOI: 10.1111/J.1471-4159.1984.TB12854.X  0.334
1984 Koller KJ, Coyle JT. Ontogenesis of N-acetyl-aspartate and N-acetyl-aspartyl-glutamate in rat brain. Brain Research. 317: 137-40. PMID 6467030 DOI: 10.1016/0165-3806(84)90150-0  0.316
1984 Sandberg K, Sanberg PR, Coyle JT. Effects of intrastriatal injections of the cholinergic neurotoxin AF64A on spontaneous nocturnal locomotor behavior in the rat. Brain Research. 299: 339-43. PMID 6329420 DOI: 10.1016/0006-8993(84)90715-7  0.318
1984 Ferkany J, Zaczek R, Markl A, Coyle JT. Glutamate-containing dipeptides enhance specific binding at glutamate receptors and inhibit specific binding at kainate receptors in rat brain. Neuroscience Letters. 44: 281-6. PMID 6328368 DOI: 10.1016/0304-3940(84)90036-3  0.335
1984 Kalia M, Fuxe K, Goldstein M, Harfstrand A, Agnati LF, Coyle JT. Evidence for the existence of putative dopamine-, adrenaline- and noradrenaline-containing vagal motor neurons in the brainstem of the rat. Neuroscience Letters. 50: 57-62. PMID 6149507 DOI: 10.1016/0304-3940(84)90462-2  0.316
1984 Singer HS, Tiemeyer M, Hedreen JC, Gearhart J, Coyle JT. Morphologic and neurochemical studies of embryonic brain development in murine trisomy 16. Brain Research. 317: 155-66. PMID 6148129 DOI: 10.1016/0165-3806(84)90093-2  0.365
1984 Coyle JT, Singer H, Beaulieu M, Johnston MV. Development of central neurotransmitter-specified neuronal systems: implications for pediatric neuro-psychiatric disorders. Acta Neurologica Scandinavica. 70: 1-11. PMID 6147947 DOI: 10.1111/J.1600-0404.1984.Tb00796.X  0.491
1984 Retz KC, Coyle JT. The differential effects of excitatory amino acids on uptake of 45CaCl2 by slices from mouse striatum. Neuropharmacology. 23: 89-94. PMID 6144068 DOI: 10.1016/0028-3908(84)90222-3  0.31
1984 Koller KJ, Coyle JT. Characterization of the interactions of N-acetyl-aspartyl-glutamate with [3H]L-glutamate receptors. European Journal of Pharmacology. 98: 193-9. PMID 6143677 DOI: 10.1016/0014-2999(84)90590-9  0.334
1984 Sandberg K, Hanin I, Fisher A, Coyle JT. Selective cholinergic neurotoxin: AF64A's effects in rat striatum. Brain Research. 293: 49-55. PMID 6142754 DOI: 10.1016/0006-8993(84)91451-3  0.35
1984 Beaulieu M, Coyle JT. Postnatal development of aminergic projections to frontal cortex: effects of cortical lesions. Journal of Neuroscience Research. 10: 351-61. PMID 6141297 DOI: 10.1002/JNR.490100403  0.347
1984 Lehmann J, Schaefer P, Ferkany JW, Coyle JT. Quinolinic acid evokes [3H]acetylcholine release in striatal slices: mediation by NMDA-type excitatory amino acid receptors. European Journal of Pharmacology. 96: 111-5. PMID 6141057 DOI: 10.1016/0014-2999(83)90536-8  0.31
1983 McKinney M, Coyle JT, Hedreen JC. Topographic analysis of the innervation of the rat neocortex and hippocampus by the basal forebrain cholinergic system. The Journal of Comparative Neurology. 217: 103-21. PMID 6875049 DOI: 10.1002/cne.902170109  0.325
1983 Coyle JT, McKinney M, Johnston MV, Hedreen JC. Synaptic neurochemistry of the basal forebrain cholinergic projection. Psychopharmacology Bulletin. 19: 441-7. PMID 6635121  0.37
1983 Coyle JT, Price DL, DeLong MR. Alzheimer's disease: a disorder of cortical cholinergic innervation. Science (New York, N.Y.). 219: 1184-90. PMID 6338589 DOI: 10.1126/Science.6338589  0.33
1983 Zaczek R, Koller K, Cotter R, Heller D, Coyle JT. N-acetylaspartylglutamate: an endogenous peptide with high affinity for a brain "glutamate" receptor. Proceedings of the National Academy of Sciences of the United States of America. 80: 1116-9. PMID 6302671 DOI: 10.1073/Pnas.80.4.1116  0.325
1983 Ferkany JW, Coyle JT. Specific binding of [3H]+/- 2-amino-7-phosphono heptanoic acid to rat brain membranes in vitro. Life Sciences. 33: 1295-305. PMID 6136884 DOI: 10.1016/0024-3205(83)90011-5  0.314
1983 Singer HS, Weaver D, Tiemeyer M, Coyle JT. Synaptic Chemistry Associated with Aberrant Neuronal Development in the Reeler Mouse Journal of Neurochemistry. 41: 874-881. PMID 6135760 DOI: 10.1111/j.1471-4159.1983.tb04821.x  0.373
1983 Slevin J, Collins J, Lindsley K, Coyle JT. Specific binding of [3H]L-glutamate to cerebellar membranes: evidence for recognition site heterogeneity. Brain Research. 249: 353-60. PMID 6128059 DOI: 10.1016/0006-8993(82)90069-5  0.337
1982 Retz KC, Coyle JT. Effects of kainic acid on high-energy metabolites in the mouse striatum. Journal of Neurochemistry. 38: 196-203. PMID 7108527 DOI: 10.1111/j.1471-4159.1982.tb10872.x  0.309
1982 Zaczek R, Coyle JT. Excitatory amino acid analogues: neurotoxicity and seizures. Neuropharmacology. 21: 15-26. PMID 7063105 DOI: 10.1016/0028-3908(82)90205-2  0.334
1982 Whitehouse PJ, Price DL, Struble RG, Clark AW, Coyle JT, Delon MR. Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain. Science (New York, N.Y.). 215: 1237-9. PMID 7058341 DOI: 10.1126/Science.7058341  0.329
1982 Beaulieu M, Coyle JT. Fetally-induced noradrenergic hyperinnervation of cerebral cortex results in persistent down-regulation of beta-receptors. Brain Research. 256: 491-4. PMID 6290000 DOI: 10.1016/0165-3806(82)90195-X  0.327
1982 Ferkany JW, Zaczek R, Coyle JT. Kainic acid stimulates excitatory amino acid neurotransmitter release at presynaptic receptors. Nature. 298: 757-9. PMID 6287270 DOI: 10.1038/298757A0  0.367
1982 McKinney M, Davies P, Coyle JT. Somatostatin is not co-localized in cholinergic neurons innervating the rat cerebral cortex-hippocampal formation. Brain Research. 243: 169-72. PMID 6126255 DOI: 10.1016/0006-8993(82)91133-7  0.344
1982 Singer HS, Coyle JT, Weaver DL, Kawamura N, Baker HJ. Neurotransmitter chemistry in feline GM1 gangliosidosis: A model for human ganglioside storage disease Annals of Neurology. 12: 37-41. PMID 6126152 DOI: 10.1002/ana.410120107  0.359
1982 Slevin JT, Johnston MV, Biziere K, Coyle JT. Methylazoxymethanol acetate ablation of mouse cerebellar granule cells: effects on synaptic neurochemistry. Developmental Neuroscience. 5: 3-12. PMID 6125372 DOI: 10.1159/000112656  0.493
1982 Johnston MV, Haddad R, Carman-Young A, Coyle JT. Neurotransmitter chemistry of lissencephalic cortex induced in ferrets by fetal treatment with methylazoxymethanol acetate. Brain Research. 256: 285-91. PMID 6125249 DOI: 10.1016/0165-3806(82)90140-7  0.507
1982 Retz KC, Young AC, Coyle JT. Glutamate stimulation of 45Ca uptake by rat striatal synaptosomes. European Journal of Pharmacology. 79: 319-22. PMID 6124433 DOI: 10.1016/0014-2999(82)90640-9  0.312
1982 Beaulieu M, Coyle JT. Effects of fetal methylazoxymethanol acetate lesion on the synaptic neurochemistry of the adult rat striatum. Journal of Neurochemistry. 37: 878-87. PMID 6119358 DOI: 10.1111/j.1471-4159.1981.tb04474.x  0.366
1982 Coyle JT. Neurotoxic amino acids in human degenerative disorders Trends in Neurosciences. 5: 287-288. DOI: 10.1016/0166-2236(82)90180-1  0.31
1982 Johnston MV, Coyle JT. Cytotoxic lesions and the development of transmitter systems Trends in Neurosciences. 5: 153-156. DOI: 10.1016/0166-2236(82)90088-1  0.497
1981 Johnston MV, Young AC, Coyle JT. Laminar distribution of cholinergic markers in neocortex: effects of lesions. Journal of Neuroscience Research. 6: 597-607. PMID 7321061 DOI: 10.1002/jnr.490060506  0.509
1981 Zaczek R, Nelson M, Coyle JT. Kainic acid neurotoxicity and seizures. Neuropharmacology. 20: 183-9. PMID 7207712 DOI: 10.1016/0028-3908(81)90202-1  0.307
1981 Zaczek R, Collins J, Coyle JT. N-Methyl-D-aspartate acid: a convulsant with weak neurotoxic properties. Neuroscience Letters. 24: 181-6. PMID 7019775 DOI: 10.1016/0304-3940(81)90245-7  0.337
1981 Olschowka JA, Molliver ME, Grzanna R, Rice FL, Coyle JT. Ultrastructural demonstration of noradrenergic synapses in the rat central nervous system by dopamine-beta-hydroxylase immunocytochemistry. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 29: 271-80. PMID 7019303 DOI: 10.1177/29.2.7019303  0.633
1981 Morrison JH, Molliver ME, Grzanna R, Coyle JT. The intra-cortical trajectory of the coeruleo-cortical projection in the rat: a tangentially organized cortical afferent. Neuroscience. 6: 139-58. PMID 7012664 DOI: 10.1016/0306-4522(81)90051-8  0.683
1981 Johnston MV, McKinney M, Coyle JT. Neocortical cholinergic innervation: a description of extrinsic and intrinsic components in the rat. Experimental Brain Research. 43: 159-72. PMID 6265265 DOI: 10.1007/Bf00237760  0.519
1981 Johnston MV, Coyle JT. Development of central neurotransmitter systems. Ciba Foundation Symposium. 86: 251-70. PMID 6121688  0.451
1981 Singer HS, Coyle JT, Frangia J, Price DL. Effects of spinal transection on presynaptic markers for glutamatergic neurons in the rat. Neurochemical Research. 6: 485-96. PMID 6116203 DOI: 10.1007/BF00964388  0.335
1981 Slevin JT, Coyle JT. Ontogeny of receptor binding sites for [3H]glutamic acid and [3H]kainic acid in the rat cerebellum. Journal of Neurochemistry. 37: 531-3. PMID 6114990 DOI: 10.1111/j.1471-4159.1981.tb00491.x  0.301
1981 Retz KC, Coyle JT. Kainic acid lesion of mouse striatum: effects on energy metabolites. Life Sciences. 27: 2495-500. PMID 6111722 DOI: 10.1016/0024-3205(80)90528-7  0.352
1981 Johnston MV, Carman AB, Coyle JT. Effects of fetal treatment with methylazoxymethanol acetate at various gestational dates on the neurochemistry of the adult neocortex of the rat. Journal of Neurochemistry. 36: 124-8. PMID 6109753 DOI: 10.1111/J.1471-4159.1981.Tb02386.X  0.493
1980 Kahn CR, Coyle JT, Cohen AM. Head and trunk neural crest in vitro: autonomic neuron differentiation. Developmental Biology. 77: 340-8. PMID 7399126 DOI: 10.1016/0012-1606(80)90479-0  0.304
1980 Biziere K, Thompson H, Coyle JT. Characterization of specific, high-affinity binding sites for L-[3H]glutamic acid in rat brain membranes. Brain Research. 183: 421-33. PMID 7353147 DOI: 10.1016/0006-8993(80)90476-X  0.341
1980 Coyle JT, Johnston MV. Functional hyperinnervation of cerebral cortex by noradrenergic neurons results from fetal lesions: parallels with schizophrenia. Psychopharmacology Bulletin. 16: 27-9. PMID 7189061  0.465
1980 Murrin LC, Coyle JT, Kuhar MJ. Striatal opiate receptors: Pre- and postsynaptic localization Life Sciences. 27: 1175-1183. PMID 6252403 DOI: 10.1016/0024-3205(80)90469-5  0.322
1980 Herndon RM, Coyle JT, Addicks E. Ultrastructural analysis of kainic acid lesion to cerebellar cortex. Neuroscience. 5: 1015-26. PMID 6157127 DOI: 10.1016/0306-4522(80)90182-7  0.343
1980 Zaczek R, Simonton S, Coyle JT. Local and distant neuronal degeneration following intrastriatal injection of kainic acid. Journal of Neuropathology and Experimental Neurology. 39: 245-64. PMID 6154134 DOI: 10.1097/00005072-198005000-00003  0.353
1980 Johnston MV, Coyle JT. Ontogeny of neurochemical markers for noradrenergic, GABAergic, and cholinergic neurons in neocortex lesioned with methylazoxymethanol acetate. Journal of Neurochemistry. 34: 1429-41. PMID 6103916 DOI: 10.1111/J.1471-4159.1980.Tb11223.X  0.524
1980 Tune LE, Creese I, Depaulo JR, Slavney PR, Coyle JT, Snyder SH. Clinical state and serum neuroleptic levels measured by radioreceptor assay in schizophrenia. The American Journal of Psychiatry. 137: 187-90. PMID 6101524 DOI: 10.1176/ajp.137.2.187  0.479
1980 Tune LE, Creese I, Coyle JT, Pearlson G, Snyder SH. Low neuroleptic serum levels in patients receiving fluphenazine decanoate. The American Journal of Psychiatry. 137: 80-2. PMID 6101523 DOI: 10.1176/ajp.137.1.80  0.427
1980 Biziere K, Coyle JT. Effects of cortical ablation on the neurotoxicity and receptor binding of kainic acid in striatum. Journal of Neuroscience Research. 4: 383-98. PMID 42811 DOI: 10.1002/JNR.490040507  0.375
1979 London ED, Coyle JT. Cooperative interactions at [3H]kainic acid binding sites in rat and human cerebellum European Journal of Pharmacology. 56: 287-290. PMID 477725 DOI: 10.1016/0014-2999(79)90186-9  0.302
1979 Morrison JH, Molliver ME, Grzanna R, Coyle JT. Noradrenergic innervation patterns in three regions of medial cortex: an immunofluorescence characterization. Brain Research Bulletin. 4: 849-57. PMID 393366 DOI: 10.1016/0361-9230(79)90022-4  0.678
1979 Johnston MV, McKinney M, Coyle JT. Evidence for a cholinergic projection to neocortex from neurons in basal forebrain. Proceedings of the National Academy of Sciences of the United States of America. 76: 5392-6. PMID 388436 DOI: 10.1073/Pnas.76.10.5392  0.49
1979 Zaczek R, Hedreen JC, Coyle JT. Evidence for a hippocampal-septal glutamatergic pathway in the rat. Experimental Neurology. 65: 145-56. PMID 233557 DOI: 10.1016/0014-4886(79)90255-3  0.336
1979 Coyle JT, Schwarcz R, Bennett JP, Campochiaro P. Clinical, neuropathologic and pharmacologic aspects of Huntington's disease: correlates with a new animal model. Progress in Neuro-Psychopharmacology. 1: 13-30. PMID 214805 DOI: 10.1016/0364-7722(77)90025-X  0.354
1979 Grzanna R, Nelson MF, Weinshilboum RM, Dunnette J, Coyle JT. Characterization of the basis for differences in serum DBH activity in immature and adult rats by use of homologous antibody. Journal of Neurochemistry. 33: 913-21. PMID 39981 DOI: 10.1111/j.1471-4159.1979.tb09921.x  0.44
1979 Johnston MV, Coyle JT. Histological and neurochemical effects of fetal treatment with methylazoxymethanol on rat neocortex in adulthood. Brain Research. 170: 135-55. PMID 37983 DOI: 10.1016/0006-8993(79)90946-6  0.545
1979 Johnston MV, Grzanna R, Coyle JT. Methylazoxymethanol treatment of fetal rats results in abnormally dense noradrenergic innervation of neocortex. Science (New York, N.Y.). 203: 369-71. PMID 32620 DOI: 10.1126/Science.32620  0.504
1978 Campochiaro P, Schwarcz R, Coyle JT. GABA receptor binding in rat striatum: localization and effects of denervation. Brain Research. 136: 501-11. PMID 922498 DOI: 10.1016/0006-8993(77)90074-9  0.324
1978 Schwarcz R, Zaczek R, Coyle JT. Microinjection of kainic acid into the rat hippocampus. European Journal of Pharmacology. 50: 209-20. PMID 689077 DOI: 10.1016/0014-2999(78)90353-9  0.377
1978 Hruska RE, Schwarcz R, Coyle JT, Yamamura HI. Alterations of muscarinic cholinergic receptors in the rat striatum after kainic acid injections. Brain Research. 152: 620-5. PMID 687979 DOI: 10.1016/0006-8993(78)91120-4  0.323
1978 Coyle JT, Molliver ME, Kuhar MJ. In situ injection of kainic acid: a new method for selectively lesioning neural cell bodies while sparing axons of passage. The Journal of Comparative Neurology. 180: 301-23. PMID 659663 DOI: 10.1002/cne.901800208  0.654
1978 Schwarcz R, Scholz D, Coyle JT. Structure-activity relations for the neurotoxicity of kainic acid derivatives and glutamate analogues. Neuropharmacology. 17: 145-51. PMID 634450 DOI: 10.1016/0028-3908(78)90127-2  0.335
1978 Schwarcz R, Creese I, Coyle JT, Snyder SH. Dopamine receptors localised on cerebral cortical afferents to rat corpus striatum. Nature. 271: 766-8. PMID 625348 DOI: 10.1038/271766a0  0.545
1978 Morrison JH, Grzanna R, Molliver ME, Coyle JT. The distribution and orientation of noradrenergic fibers in neocortex of the rat: an immunofluorescence study. The Journal of Comparative Neurology. 181: 17-39. PMID 355267 DOI: 10.1002/cne.901810103  0.676
1978 Grzanna R, Molliver ME, Coyle JT. Visualization of central noradrenergic neurons in thick sections by the unlabeled antibody method: a transmitter-specific Golgi image. Proceedings of the National Academy of Sciences of the United States of America. 75: 2502-6. PMID 353813 DOI: 10.1073/Pnas.75.5.2502  0.636
1978 Campochiaro P, Coyle JT. Ontogenetic development of kainate neurotoxicity: correlates with glutamatergic innervation. Proceedings of the National Academy of Sciences of the United States of America. 75: 2025-9. PMID 25442 DOI: 10.1073/PNAS.75.4.2025  0.387
1978 Coyle JT. Biochemical aspects of neurotransmission in the developing brain. International Review of Neurobiology. 20: 65-103. PMID 22512 DOI: 10.1016/S0074-7742(08)60651-0  0.338
1978 Coyle JT. Neuronal mapping with kainic acid Trends in Neurosciences. 1: 132-135. DOI: 10.1016/0166-2236(78)90088-7  0.334
1977 Grzanna R, Morrison JH, Coyle JT, Molliver ME. The immunohistochemical demonstration of noradrenergic neurons in the rat brain: The use of homologous antiserum to dopamine-beta-hydroxylase. Neuroscience Letters. 4: 127-34. PMID 19604933 DOI: 10.1016/0304-3940(77)90127-6  0.686
1977 Coyle JT, Molliver ME. Major innervation of newborn rat cortex by monoaminergic neurons. Science (New York, N.Y.). 196: 444-7. PMID 850788  0.614
1977 Schwarcz R, Bennett JP, Coyle JT. Loss of striatal serotonin synaptic receptor binding induced by kainic acid lesions: correlations with Huntington's Disease. Journal of Neurochemistry. 28: 867-9. PMID 142820 DOI: 10.1111/J.1471-4159.1977.Tb10641.X  0.309
1977 Schwarcz R, Coyle JT. Striatal lesions with kainic acid: neurochemical characteristics. Brain Research. 127: 235-49. PMID 16686 DOI: 10.1016/0006-8993(77)90538-8  0.362
1977 Schwarcz R, Coyle JT. Neurochemical sequelae of kainate injections in corpus striatum and substantia nigra of the rat. Life Sciences. 20: 431-6. PMID 14287 DOI: 10.1016/0024-3205(77)90384-8  0.341
1977 Grzanna R, Morrison JH, Coyle JT, Molliver ME. The immunohistochemical demonstration of noradrenergic neurons in the rat brain: The use of homologous antiserum to dopamine-β-hydroxylase Neuroscience Letters. 4: 127-134. DOI: 10.1016/0304-3940(77)90127-6  0.666
1976 Coyle JT, Enna SJ. Neurochemical aspects of the ontogenesis of GABAnergic neurons in the rat brain. Brain Research. 111: 119-33. PMID 953691 DOI: 10.1016/0006-8993(76)91053-2  0.317
1976 Coyle JT, Campochiaro P. Ontogenesis of dopaminergic-cholinergic interactions in the rat striatum: a neurochemical study. Journal of Neurochemistry. 27: 673-8. PMID 9481 DOI: 10.1111/j.1471-4159.1976.tb10393.x  0.324
1976 Coyle JT, Schwarcz R. Lesion of striatal neurones with kainic acid provides a model for Huntington's chorea. Nature. 263: 244-6. PMID 8731 DOI: 10.1038/263244a0  0.344
1974 Saavedra JM, Coyle JT, Axelrod J. Developmental characteristics of phenylethanolamine and octopamine in the rat brain. Journal of Neurochemistry. 23: 511-5. PMID 4153859  0.582
1974 Coyle JT, Wooten GF, Axelrod J. Evidence for extranoradrenergic dopamine-beta-hydroxylase activity in rat salivary gland. Journal of Neurochemistry. 22: 923-9. PMID 4152880 DOI: 10.1111/j.1471-4159.1974.tb04316.x  0.347
1973 Saavedra JM, Coyle JT, Axelrod J. The distribution and properties of the nonspecific N-methyltransferase in brain. Journal of Neurochemistry. 20: 743-52. PMID 4703789  0.576
1973 Coyle JT, Jacobowitz D, Klein D, Axelrod J. Dopaminergic neurons in explants of substantia nigra in culture. Journal of Neurobiology. 4: 461-70. PMID 4147763 DOI: 10.1002/neu.480040507  0.394
1973 Coyle JT, Wender P, Lipsky A. Avoidance conditioning in different strains of rats: neurochemical correlates. Psychopharmacologia. 31: 25-34. PMID 4146488 DOI: 10.1007/BF00429296  0.316
1973 Coyle JT, Henry D. Catecholamines in fetal and newborn rat brain. Journal of Neurochemistry. 21: 61-7. PMID 4146461 DOI: 10.1111/j.1471-4159.1973.tb04225.x  0.306
1972 Coyle JT, Axelrod J. Dopamine- -hydroxylase in the rat brain: developmental characteristics. Journal of Neurochemistry. 19: 449-59. PMID 4621978 DOI: 10.1111/j.1471-4159.1972.tb01354.x  0.376
1972 Coyle JT, Axelrod J. Tyrosine hydroxylase in rat brain: developmental characteristics. Journal of Neurochemistry. 19: 1117-23. PMID 4401682  0.359
1971 Coyle JT, Axelrod J. Development of the uptake and storage of L-( 3 H)norepinephrine in the rat brain. Journal of Neurochemistry. 18: 2061-75. PMID 5129345 DOI: 10.1111/j.1471-4159.1971.tb05065.x  0.352
1970 Snyder SH, Taylor KM, Coyle JT, Meyerhoff JL. The role of brain dopamine in behavioral regulation and the actions of psychotropic drugs. The American Journal of Psychiatry. 127: 199-207. PMID 4319649 DOI: 10.1176/Ajp.127.2.199  0.534
1970 Snyder SH, Kuhar MJ, Green AI, Coyle JT, Shaskan EG. Uptake and Subcellular Localization of Neurotransmitters in the Brain International Review of Neurobiology. 13: 127-158. DOI: 10.1016/S0074-7742(08)60168-3  0.525
1969 Coyle JT, Snyder SH. Antiparkinsonian drugs: inhibition of dopamine uptake in the corpus striatum as a possible mechanism of action. Science (New York, N.Y.). 166: 899-901. PMID 5345207 DOI: 10.1126/science.166.3907.899  0.5
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