| Year |
Citation |
Score |
| 2019 |
Uemura T, Tsaprailis G, Gerner EW. GSTΠ stimulates caveolin-1-regulated polyamine uptake via actin remodeling. Oncotarget. 10: 5713-5723. PMID 31620246 DOI: 10.18632/Oncotarget.27192 |
0.328 |
|
| 2019 |
Hines RN, Klick DE, Koukouritaki SB, Gerner EW, Thompson P, Jr MFL. Flavin-Containing monooxygenases Drug Metabolism Reviews. 41: 17-18. DOI: 10.2210/Pdb5Z8T/Pdb |
0.36 |
|
| 2018 |
Gerner EW, Bruckheimer E, Cohen A. Cancer pharmacoprevention: Targeting polyamine metabolism to manage risk factors for colon cancer. The Journal of Biological Chemistry. PMID 30355737 DOI: 10.1074/Jbc.Tm118.003343 |
0.457 |
|
| 2017 |
Chandra S, Nymeyer AC, Rice PF, Gerner EW, Barton JK. Intermittent dosing with sulindac provides effective colorectal cancer chemoprevention in the azoxymethane-treated mouse model. Cancer Prevention Research (Philadelphia, Pa.). PMID 28611038 DOI: 10.1158/1940-6207.Capr-17-0038 |
0.35 |
|
| 2015 |
Roy UKB, Henkhaus RS, Loupakis F, Cremolini C, Gerner EW, Ignatenko NA. Erratum: Caveolin-1 is a novel regulator of K-RASdependent migration in colon carcinogenesis (International Journal of Cancer (2013) 133: 1 (43-57) DOI: 10.1002/ijc.28001) International Journal of Cancer. 137. PMID 26252817 DOI: 10.1002/Ijc.29624 |
0.769 |
|
| 2014 |
Meyskens FL, Simoneau AR, Gerner EW. Chemoprevention of prostate cancer with the polyamine synthesis inhibitor difluoromethylornithine. Recent Results in Cancer Research. Fortschritte Der Krebsforschung. ProgrèS Dans Les Recherches Sur Le Cancer. 202: 115-20. PMID 24531785 DOI: 10.1007/978-3-642-45195-9_14 |
0.31 |
|
| 2014 |
Paz EA, LaFleur B, Gerner EW. Polyamines are oncometabolites that regulate the LIN28/let-7 pathway in colorectal cancer cells. Molecular Carcinogenesis. 53: E96-106. PMID 23737330 DOI: 10.1002/Mc.22051 |
0.379 |
|
| 2013 |
Wen F, Shen A, Choi A, Gerner EW, Shi J. Extracellular DNA in pancreatic cancer promotes cell invasion and metastasis. Cancer Research. 73: 4256-66. PMID 23722544 DOI: 10.1158/0008-5472.Can-12-3287 |
0.406 |
|
| 2013 |
Ignatenko NA, Gerner EW. Get the fat out! Cancer Prevention Research (Philadelphia, Pa.). 6: 161-4. PMID 23466814 DOI: 10.1158/1940-6207.Capr-13-0025 |
0.305 |
|
| 2013 |
Samal K, Zhao P, Kendzicky A, Yco LP, McClung H, Gerner E, Burns M, Bachmann AS, Sholler G. AMXT-1501, a novel polyamine transport inhibitor, synergizes with DFMO in inhibiting neuroblastoma cell proliferation by targeting both ornithine decarboxylase and polyamine transport International Journal of Cancer. 133: 1323-1333. PMID 23457004 DOI: 10.1002/Ijc.28139 |
0.381 |
|
| 2013 |
Basu Roy UK, Henkhaus RS, Loupakis F, Cremolini C, Gerner EW, Ignatenko NA. Caveolin-1 is a novel regulator of K-RAS-dependent migration in colon carcinogenesis. International Journal of Cancer. 133: 43-57. PMID 23280667 DOI: 10.1002/Ijc.28001 |
0.771 |
|
| 2013 |
Kendzicky AM, Zhao P, Samal K, Yco LP, McClung H, Gerner EW, Bachmann AS, Sholler GL. Abstract 2765: Targeting both ornithine decarboxylase and polyamine transport inhibits tumor growth in neuroblastoma. Cancer Research. 73: 2765-2765. DOI: 10.1158/1538-7445.Am2013-2765 |
0.404 |
|
| 2012 |
Laukaitis CM, Erdman SH, Gerner EW. Chemoprevention in patients with genetic risk of colorectal cancers. Colorectal Cancer. 1: 225-240. PMID 25221625 DOI: 10.2217/Crc.12.22 |
0.315 |
|
| 2012 |
Vargas AJ, Wertheim BC, Gerner EW, Thomson CA, Rock CL, Thompson PA. Dietary polyamine intake and risk of colorectal adenomatous polyps. The American Journal of Clinical Nutrition. 96: 133-41. PMID 22648715 DOI: 10.3945/Ajcn.111.030353 |
0.316 |
|
| 2012 |
Gerner EW. Abstract CN04-03: Development of NSAID eflornithine combinations for treating cancer risk factors Cancer Prevention Research. 5: CN04-03-CN04-03. DOI: 10.1158/1940-6207.Prev-12-Cn04-03 |
0.381 |
|
| 2011 |
Laukaitis CM, Gerner EW. DFMO: targeted risk reduction therapy for colorectal neoplasia. Best Practice & Research. Clinical Gastroenterology. 25: 495-506. PMID 22122766 DOI: 10.1016/J.Bpg.2011.09.007 |
0.343 |
|
| 2011 |
Ignatenko NA, Gerner EW, Besselsen DG. Defining the role of polyamines in colon carcinogenesis using mouse models. Journal of Carcinogenesis. 10: 10. PMID 21712957 DOI: 10.4103/1477-3163.79673 |
0.371 |
|
| 2011 |
Sinicrope FA, Broaddus R, Joshi N, Gerner E, Half E, Kirsch I, Lewin J, Morlan B, Hong WK. Evaluation of difluoromethylornithine for the chemoprevention of Barrett's esophagus and mucosal dysplasia Cancer Prevention Research. 4: 829-839. PMID 21636549 DOI: 10.1158/1940-6207.Capr-10-0243 |
0.411 |
|
| 2011 |
Meyskens FL, Gerner EW. Back to the future: mechanism-based, mutation-specific combination chemoprevention with a synthetic lethality approach. Cancer Prevention Research (Philadelphia, Pa.). 4: 628-32. PMID 21543341 DOI: 10.1158/1940-6207.Capr-11-0162 |
0.3 |
|
| 2011 |
Thompson PA, Gerner EW. Of timing and surrogates: a way forward for cancer chemoprevention. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 3509-11. PMID 21498391 DOI: 10.1158/1078-0432.Ccr-11-0643 |
0.338 |
|
| 2011 |
Uemura T, Gerner EW. Polyamine transport systems in mammalian cells and tissues. Methods in Molecular Biology (Clifton, N.J.). 720: 339-48. PMID 21318884 DOI: 10.1007/978-1-61779-034-8_21 |
0.353 |
|
| 2011 |
Babbar N, Gerner EW. Targeting polyamines and inflammation for cancer prevention. Recent Results in Cancer Research. Fortschritte Der Krebsforschung. ProgrèS Dans Les Recherches Sur Le Cancer. 188: 49-64. PMID 21253788 DOI: 10.1007/978-3-642-10858-7_4 |
0.766 |
|
| 2011 |
Zell JA, McLaren CE, Albers CG, Gerner EW, Wenzel LB, Meyskens FL. A phase IIa clinical biomarker trial of aspirin and dietary arginine restriction in colorectal cancer patients. Journal of Clinical Oncology. 29: TPS132-TPS132. DOI: 10.1200/Jco.2011.29.15_Suppl.Tps132 |
0.315 |
|
| 2011 |
Carpenter PM, Chen W, McLaren CE, Gerner EW, Meyskens FL. Abstract PR-01: Properties of adenomas in subjects treated with difluoromethylornithine and sulindac for reduction of colorectal adenomas Cancer Prevention Research. 4. DOI: 10.1158/1940-6207.Prev-11-Pr-01 |
0.365 |
|
| 2010 |
Thompson PA, Wertheim BC, Zell JA, Chen WP, McLaren CE, LaFleur BJ, Meyskens FL, Gerner EW. Levels of rectal mucosal polyamines and prostaglandin E2 predict ability of DFMO and sulindac to prevent colorectal adenoma. Gastroenterology. 139: 797-805, 805.e1. PMID 20538001 DOI: 10.1053/J.Gastro.2010.06.005 |
0.31 |
|
| 2010 |
Uemura T, Stringer DE, Blohm-Mangone KA, Gerner EW. Polyamine transport is mediated by both endocytic and solute carrier transport mechanisms in the gastrointestinal tract. American Journal of Physiology. Gastrointestinal and Liver Physiology. 299: G517-22. PMID 20522643 DOI: 10.1152/Ajpgi.00169.2010 |
0.328 |
|
| 2010 |
Gerner EW. Cancer chemoprevention locks onto a new polyamine metabolic target. Cancer Prevention Research (Philadelphia, Pa.). 3: 125-7. PMID 20103728 DOI: 10.1158/1940-6207.Capr-09-0252 |
0.333 |
|
| 2010 |
Egan JB, Thompson PA, Vitanov MV, Bartik L, Jacobs ET, Haussler MR, Gerner EW, Jurutka PW. Vitamin D receptor ligands, adenomatous polyposis coli, and the vitamin D receptor FokI polymorphism collectively modulate beta-catenin activity in colon cancer cells. Molecular Carcinogenesis. 49: 337-52. PMID 20043299 DOI: 10.1002/Mc.20603 |
0.32 |
|
| 2010 |
Laukaitis CM, Thompson P, Martinez M, Gerner EW. Identifying gene copy number variants associated with colorectal adenoma recurrence Genome Biology. 11: P24. DOI: 10.1186/Gb-2010-11-S1-P24 |
0.369 |
|
| 2010 |
Gerner EW. Abstract PL01-04: ODC genotype as prognostic and predictive factors in colorectal carcinogenesis and prevention Cancer Prevention Research. 3. DOI: 10.1158/1940-6207.Prev-10-Pl01-04 |
0.435 |
|
| 2010 |
Thompson PA, Wertheim BC, Zell JA, LeFleur B, Chen W, McLaren CE, Meyskens FL, Gerner EW. Abstract A29: Rectal mucosal polyamine and PGE2 levels and risk of colorectal adenomas in a phase IIb/III trial of combination difluoromethylornithine (DFMO) plus sulindac Cancer Prevention Research. 3. DOI: 10.1158/1940-6207.Prev-09-A29 |
0.312 |
|
| 2009 |
Rial NS, Meyskens FL, Gerner EW. Polyamines as mediators of APC-dependent intestinal carcinogenesis and cancer chemoprevention. Essays in Biochemistry. 46: 111-24. PMID 20095973 DOI: 10.1042/Bse0460008 |
0.377 |
|
| 2009 |
Zell JA, Ziogas A, Ignatenko N, Honda J, Qu N, Bobbs AS, Neuhausen SL, Gerner EW, Anton-Culver H. Associations of a polymorphism in the ornithine decarboxylase gene with colorectal cancer survival. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 6208-16. PMID 19789310 DOI: 10.1158/1078-0432.Ccr-09-0592 |
0.391 |
|
| 2009 |
Thompson PA, Gerner EW. Current concepts in colorectal cancer prevention. Expert Review of Gastroenterology & Hepatology. 3: 369-82. PMID 19673624 DOI: 10.1586/Egh.09.28 |
0.361 |
|
| 2009 |
Ignatenko NA, Yerushalmi HF, Pandey R, Kachel KL, Stringer DE, Marton LJ, Gerner EW. Gene expression analysis of HCT116 colon tumor-derived cells treated with the polyamine analog PG-11047. Cancer Genomics & Proteomics. 6: 161-75. PMID 19487545 |
0.31 |
|
| 2009 |
Gerner EW, Meyskens FL. Combination chemoprevention for colon cancer targeting polyamine synthesis and inflammation. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 758-61. PMID 19188144 DOI: 10.1158/1078-0432.Ccr-08-2235 |
0.394 |
|
| 2009 |
Rial NS, Lazennec G, Prasad AR, Krouse RS, Lance P, Gerner EW. Regulation of deoxycholate induction of CXCL8 by the adenomatous polyposis coli gene in colorectal cancer. International Journal of Cancer. 124: 2270-80. PMID 19173296 DOI: 10.1002/Ijc.24226 |
0.441 |
|
| 2008 |
Abate-Shen C, Brown PH, Colburn NH, Gerner EW, Green JE, Lipkin M, Nelson WG, Threadgill D. The untapped potential of genetically engineered mouse models in chemoprevention research: opportunities and challenges. Cancer Prevention Research (Philadelphia, Pa.). 1: 161-6. PMID 19138951 DOI: 10.1158/1940-6207.Capr-08-0076 |
0.315 |
|
| 2008 |
Ignatenko NA, Besselsen DG, Stringer DE, Blohm-Mangone KA, Cui H, Gerner EW. Combination chemoprevention of intestinal carcinogenesis in a murine model of familial adenomatous polyposis. Nutrition and Cancer. 60: 30-5. PMID 19003578 DOI: 10.1080/01635580802401317 |
0.344 |
|
| 2008 |
Uemura T, Yerushalmi HF, Tsaprailis G, Stringer DE, Pastorian KE, Hawel L, Byus CV, Gerner EW. Identification and characterization of a diamine exporter in colon epithelial cells. The Journal of Biological Chemistry. 283: 26428-35. PMID 18660501 DOI: 10.1074/Jbc.M804714200 |
0.42 |
|
| 2008 |
Egan JB, Jacobs ET, MartÃnez ME, Gerner EW, Jurutka PW, Thompson PA. Presence of a TA haplotype in the APC gene containing the common 1822 polymorphism and colorectal adenoma. Cancer Research. 68: 6006-13. PMID 18632657 DOI: 10.1158/0008-5472.Can-08-1084 |
0.351 |
|
| 2008 |
Henkhaus RS, Gerner EW, Ignatenko NA. Kallikrein 6 is a mediator of K-RAS-dependent migration of colon carcinoma cells. Biological Chemistry. 389: 757-64. PMID 18627290 DOI: 10.1515/Bc.2008.087 |
0.792 |
|
| 2008 |
Roy UK, Henkhaus RS, Ignatenko NA, Mora J, Fultz KE, Gerner EW. Wild-type APC regulates caveolin-1 expression in human colon adenocarcinoma cell lines via FOXO1a and C-myc. Molecular Carcinogenesis. 47: 947-55. PMID 18444242 DOI: 10.1002/Mc.20451 |
0.782 |
|
| 2008 |
Ignatenko NA, Gerner EW. HuRrying colon cancer progression. Cancer Biology & Therapy. 7: 428-9. PMID 18285701 DOI: 10.4161/Cbt.7.3.5583 |
0.323 |
|
| 2008 |
Henkhaus RS, Roy UK, Cavallo-Medved D, Sloane BF, Gerner EW, Ignatenko NA. Caveolin-1-mediated expression and secretion of kallikrein 6 in colon cancer cells. Neoplasia (New York, N.Y.). 10: 140-8. PMID 18283336 DOI: 10.1593/Neo.07817 |
0.801 |
|
| 2008 |
Roy UK, Rial NS, Kachel KL, Gerner EW. Activated K-RAS increases polyamine uptake in human colon cancer cells through modulation of caveolar endocytosis. Molecular Carcinogenesis. 47: 538-53. PMID 18176934 DOI: 10.1002/Mc.20414 |
0.44 |
|
| 2008 |
Zell JA, McLaren CE, Gerner EW, Meyskens FL. Ornithine decarboxylase (Odc)-1 gene polymorphism effects on baseline tissue polyamine levels and adenoma recurrence in a randomized phase III adenoma prevention trial of DFMO + sulindac versus placebo Journal of Clinical Oncology. 26: 1502-1502. DOI: 10.1200/Jco.2008.26.15_Suppl.1502 |
0.3 |
|
| 2007 |
Jiang R, Choi W, Hu L, Gerner EW, Hamilton SR, Zhang W. Activation of polyamine catabolism by N1, N11-diethylnorspermine alters the cellular localization of mTOR and downregulates mTOR protein level in glioblastoma cells. Cancer Biology & Therapy. 6: 1644-8. PMID 17921698 DOI: 10.4161/Cbt.6.10.4800 |
0.386 |
|
| 2007 |
Gerner EW, Meyskens FL, Goldschmid S, Lance P, Pelot D. Rationale for, and design of, a clinical trial targeting polyamine metabolism for colon cancer chemoprevention. Amino Acids. 33: 189-95. PMID 17396214 DOI: 10.1007/S00726-007-0515-2 |
0.393 |
|
| 2007 |
Gerner EW. Impact of dietary amino acids and polyamines on intestinal carcinogenesis and chemoprevention in mouse models. Biochemical Society Transactions. 35: 322-5. PMID 17371270 DOI: 10.1042/BST0350322 |
0.307 |
|
| 2007 |
Bernstein H, Holubec H, Bernstein C, Ignatenko NA, Gerner E, Dvorak K, Besselsen D, Blohm-Mangone KA, Padilla-Torres J, Dvorakova B, Garewal H, Payne CM. Deoxycholate-induced colitis is markedly attenuated in Nos2 knockout mice in association with modulation of gene expression profiles. Digestive Diseases and Sciences. 52: 628-42. PMID 17253130 DOI: 10.1007/S10620-006-9608-0 |
0.307 |
|
| 2007 |
Zell JA, Ignatenko NA, Yerushalmi HF, Ziogas A, Besselsen DG, Gerner EW, Anton-Culver H. Risk and risk reduction involving arginine intake and meat consumption in colorectal tumorigenesis and survival. International Journal of Cancer. 120: 459-68. PMID 17096347 DOI: 10.1002/Ijc.22311 |
0.342 |
|
| 2007 |
Jiang R, Choi W, Khan A, Hess KR, Gerner EW, Casero RA, Yung WKA, Hamilton SR, Zhang W. Activation of polyamine catabolism by N1,N11-diethylnorspermine leads to cell death in glioblastoma International Journal of Oncology. 31: 431-440. DOI: 10.3892/Ijo.31.2.431 |
0.384 |
|
| 2006 |
Ignatenko NA, Besselsen DG, Roy UK, Stringer DE, Blohm-Mangone KA, Padilla-Torres JL, Guillen-R JM, Gerner EW. Dietary putrescine reduces the intestinal anticarcinogenic activity of sulindac in a murine model of familial adenomatous polyposis. Nutrition and Cancer. 56: 172-81. PMID 17474863 DOI: 10.1207/S15327914Nc5602_8 |
0.357 |
|
| 2006 |
Ignatenko NA, Yerushalmi HF, Watts GS, Futscher BW, Stringer DE, Marton LJ, Gerner EW. Pharmacogenomics of the polyamine analog 3,8,13,18-tetraaza-10,11-[(E)-1,2-cyclopropyl]eicosane tetrahydrochloride, CGC-11093, in the colon adenocarcinoma cell line HCT1161. Technology in Cancer Research & Treatment. 5: 553-64. PMID 17121431 DOI: 10.1177/153303460600500602 |
0.415 |
|
| 2006 |
Ignatenko NA, Holubec H, Besselsen DG, Blohm-Mangone KA, Padilla-Torres JL, Nagle RB, de Alboránç IM, Guillen-R JM, Gerner EW. Role of c-Myc in intestinal tumorigenesis of the ApcMin/+ mouse. Cancer Biology & Therapy. 5: 1658-64. PMID 17106247 DOI: 10.4161/Cbt.5.12.3376 |
0.351 |
|
| 2006 |
Yerushalmi HF, Besselsen DG, Ignatenko NA, Blohm-Mangone KA, Padilla-Torres JL, Stringer DE, Guillen JM, Holubec H, Payne CM, Gerner EW. Role of polyamines in arginine-dependent colon carcinogenesis in Apc(Min) (/+) mice. Molecular Carcinogenesis. 45: 764-73. PMID 16705737 DOI: 10.1002/Mc.20246 |
0.332 |
|
| 2006 |
Choi W, Proctor L, Xia Q, Feng Y, Gerner EW, Chiao PJ, Hamilton SR, Zhang W. Inactivation of IkappaB contributes to transcriptional activation of spermidine/spermine N(1)-acetyltransferase. Molecular Carcinogenesis. 45: 685-93. PMID 16637064 DOI: 10.1002/Mc.20239 |
0.421 |
|
| 2006 |
Bernstein H, Holubec H, Bernstein C, Ignatenko N, Gerner E, Dvorak K, Besselsen D, Ramsey L, Dall'Agnol M, Blohm-Mangone KA, Padilla-Torres J, Cui H, Garewal H, Payne CM. Unique dietary-related mouse model of colitis. Inflammatory Bowel Diseases. 12: 278-93. PMID 16633050 DOI: 10.1097/01.Mib.0000209789.14114.63 |
0.348 |
|
| 2006 |
Basuroy UK, Gerner EW. Emerging concepts in targeting the polyamine metabolic pathway in epithelial cancer chemoprevention and chemotherapy. Journal of Biochemistry. 139: 27-33. PMID 16428316 DOI: 10.1093/jb/mvj022 |
0.323 |
|
| 2006 |
Yerushalmi HF, Besselsen DG, Ignatenko NA, Blohm-Mangone KA, Padilla-Torres JL, Stringer DE, Cui H, Holubec H, Payne CM, Gerner EW. The role of NO synthases in arginine-dependent small intestinal and colonic carcinogenesis. Molecular Carcinogenesis. 45: 93-105. PMID 16329147 DOI: 10.1002/Mc.20168 |
0.339 |
|
| 2006 |
Babbar N, Gerner EW, Casero RA. Induction of spermidine/spermine N1-acetyltransferase (SSAT) by aspirin in Caco-2 colon cancer cells. The Biochemical Journal. 394: 317-24. PMID 16262603 DOI: 10.1042/Bj20051298 |
0.79 |
|
| 2005 |
Gerner EW, Ignatenko NA, Lance P, Hurley LH. A comprehensive strategy to combat colon cancer targeting the adenomatous polyposis coli tumor suppressor gene. Annals of the New York Academy of Sciences. 1059: 97-105. PMID 16382048 DOI: 10.1196/Annals.1339.033 |
0.464 |
|
| 2005 |
Choi W, Gerner EW, Ramdas L, Dupart J, Carew J, Proctor L, Huang P, Zhang W, Hamilton SR. Combination of 5-fluorouracil and N1,N11-diethylnorspermine markedly activates spermidine/spermine N1-acetyltransferase expression, depletes polyamines, and synergistically induces apoptosis in colon carcinoma cells. The Journal of Biological Chemistry. 280: 3295-304. PMID 15546879 DOI: 10.1074/Jbc.M409930200 |
0.376 |
|
| 2004 |
Ignatenko NA, Zhang H, Watts GS, Skovan BA, Stringer DE, Gerner EW. The chemopreventive agent alpha-difluoromethylornithine blocks Ki-ras-dependent tumor formation and specific gene expression in Caco-2 cells. Molecular Carcinogenesis. 39: 221-33. PMID 15057874 DOI: 10.1002/Mc.20008 |
0.424 |
|
| 2004 |
Ignatenko NA, Babbar N, Mehta D, Casero RA, Gerner EW. Suppression of polyamine catabolism by activated Ki-ras in human colon cancer cells. Molecular Carcinogenesis. 39: 91-102. PMID 14750214 DOI: 10.1002/Mc.10166 |
0.783 |
|
| 2003 |
Babbar N, Ignatenko NA, Casero RA, Gerner EW. Cyclooxygenase-independent induction of apoptosis by sulindac sulfone is mediated by polyamines in colon cancer. The Journal of Biological Chemistry. 278: 47762-75. PMID 14506281 DOI: 10.1074/Jbc.M307265200 |
0.8 |
|
| 2003 |
Childs AC, Mehta DJ, Gerner EW. Polyamine-dependent gene expression. Cellular and Molecular Life Sciences : Cmls. 60: 1394-406. PMID 12943227 DOI: 10.1007/s00018-003-2332-4 |
0.751 |
|
| 2003 |
Gerner EW, Ignatenko NA, Besselsen DG. Preclinical models for chemoprevention of colon cancer. Recent Results in Cancer Research. Fortschritte Der Krebsforschung. ProgrèS Dans Les Recherches Sur Le Cancer. 163: 58-71; discussion 26. PMID 12903843 DOI: 10.1007/978-3-642-55647-0_6 |
0.398 |
|
| 2003 |
Martinez ME, O'Brien TG, Fultz KE, Babbar N, Yerushalmi H, Qu N, Guo Y, Boorman D, Einspahr J, Alberts DS, Gerner EW. Pronounced reduction in adenoma recurrence associated with aspirin use and a polymorphism in the ornithine decarboxylase gene. Proceedings of the National Academy of Sciences of the United States of America. 100: 7859-64. PMID 12810952 DOI: 10.1073/Pnas.1332465100 |
0.778 |
|
| 2003 |
Husbeck B, Stringer DE, Gerner EW, Powis G. Increased thioredoxin-1 inhibits SSAT expression in MCF-7 human breast cancer cells. Biochemical and Biophysical Research Communications. 306: 469-75. PMID 12804587 DOI: 10.1016/S0006-291X(03)00993-8 |
0.445 |
|
| 2003 |
Babbar N, Gerner EW. Polyamines as modifiers of genetic risk factors in human intestinal cancers. Biochemical Society Transactions. 31: 388-92. PMID 12653645 DOI: 10.1042/ |
0.793 |
|
| 2003 |
Martinez JD, Parker MT, Fultz KE, Ignatenko NA, Gerner EW. Molecular Biology of Cancer Burger's Medicinal Chemistry and Drug Discovery. 1-50. DOI: 10.1002/0471266949.Bmc074 |
0.77 |
|
| 2002 |
Parker MT, Gerner EW. Polyamine-mediated post-transcriptional regulation of COX-2. Biochimie. 84: 815-9. PMID 12457568 DOI: 10.1016/S0300-9084(02)01439-6 |
0.408 |
|
| 2002 |
Baines A, Taylor-Parker M, Goulet AC, Renaud C, Gerner EW, Nelson MA. Selenomethionine inhibits growth and suppresses cyclooxygenase-2 (COX-2) protein expression in human colon cancer cell lines. Cancer Biology & Therapy. 1: 370-4. PMID 12432249 DOI: 10.4161/Cbt.1.4.9 |
0.458 |
|
| 2002 |
Fultz KE, Gerner EW. APC-dependent regulation of ornithine decarboxylase in human colon tumor cells. Molecular Carcinogenesis. 34: 10-8. PMID 12112318 DOI: 10.1002/Mc.10043 |
0.782 |
|
| 2002 |
Gerner EW, Ignatenko NA, Besselsen DG. Session 4 S9. Genetically altered rodents and human tumor cells as preclinical models for prevention of intestinal cancers European Journal of Cancer. 38: S12. DOI: 10.1016/S0959-8049(02)80617-7 |
0.377 |
|
| 2001 |
Simoneau AR, Gerner EW, Phung M, McLaren CE, Meyskens FL. Alpha-difluoromethylornithine and polyamine levels in the human prostate: results of a phase IIa trial. Journal of the National Cancer Institute. 93: 57-9. PMID 11136843 DOI: 10.1093/Jnci/93.1.57 |
0.306 |
|
| 2000 |
Taylor MT, Lawson KR, Ignatenko NA, Marek SE, Stringer DE, Skovan BA, Gerner EW. Sulindac sulfone inhibits K-ras-dependent cyclooxygenase-2 expression in human colon cancer cells. Cancer Research. 60: 6607-10. PMID 11118042 |
0.363 |
|
| 2000 |
Lawson KR, Ignatenko NA, Piazza GA, Cui H, Gerner EW. Influence of K-ras activation on the survival responses of Caco-2 cells to the chemopreventive agents sulindac and difluoromethylornithine Cancer Epidemiology Biomarkers and Prevention. 9: 1155-1162. PMID 11097222 |
0.326 |
|
| 2000 |
List AF, Gerner EW. Amifostine: a tonic or toxin to myeloid progenitors. Leukemia Research. 24: 1009-11. PMID 11077114 DOI: 10.1016/S0145-2126(00)00081-3 |
0.412 |
|
| 2000 |
Washo-Stultz D, Crowley C, Payne CM, Bernstein C, Marek S, Gerner EW, Bernstein H. Increased susceptibility of cells to inducible apoptosis during growth from early to late log phase: an important caveat for in vitro apoptosis research. Toxicology Letters. 116: 199-207. PMID 10996481 DOI: 10.1016/S0378-4274(00)00225-3 |
0.312 |
|
| 2000 |
Earnest DL, Martinez JD, Batta AK, Salen G, Gerner EW, Alberts DS. Increasing the ursodeoxycholate (UDC): deoxycholate (DCA) ratio in model fecal water solutions enhances apoptosis of colon cancer cells. Possible mechanism for cancer chemoprevention effect of UDC The American Journal of Gastroenterology. 95: 2532-2533. DOI: 10.1016/S0002-9270(00)01571-9 |
0.382 |
|
| 1999 |
Payne CM, Bernstein C, Bernstein H, Gerner EW, Garewal H. Reactive nitrogen species in colon carcinogenesis. Antioxidants & Redox Signaling. 1: 449-67. PMID 11233144 DOI: 10.1089/Ars.1999.1.4-449 |
0.414 |
|
| 1999 |
Erdman SH, Ignatenko NA, Powell MB, Blohm-Mangone KA, Holubec H, Guillén-Rodriguez JM, Gerner EW. APC-dependent changes in expression of genes influencing polyamine metabolism, and consequences for gastrointestinal carcinogenesis, in the Min mouse. Carcinogenesis. 20: 1709-13. PMID 10469614 DOI: 10.1093/Carcin/20.9.1709 |
0.378 |
|
| 1998 |
Martinez JD, Stratagoules ED, LaRue JM, Powell AA, Gause PR, Craven MT, Payne CM, Powell MB, Gerner EW, Earnest DL. Different bile acids exhibit distinct biological effects: the tumor promoter deoxycholic acid induces apoptosis and the chemopreventive agent ursodeoxycholic acid inhibits cell proliferation. Nutrition and Cancer. 31: 111-8. PMID 9770722 DOI: 10.1080/01635589809514689 |
0.33 |
|
| 1998 |
Meyskens FL, Gerner EW, Emerson S, Pelot D, Durbin T, Doyle K, Lagerberg W. Effect of alpha-difluoromethylornithine on rectal mucosal levels of polyamines in a randomized, double-blinded trial for colon cancer prevention. Journal of the National Cancer Institute. 90: 1212-8. PMID 9719082 DOI: 10.1093/Jnci/90.16.1212 |
0.395 |
|
| 1997 |
Erdman SH, Wu HD, Hixson LJ, Ahnen DJ, Gerner EW. Assessment of mutations in Ki-ras and p53 in colon cancers from azoxymethane- and dimethylhydrazine-treated rats Molecular Carcinogenesis. 19: 137-144. PMID 9210960 DOI: 10.1002/(Sici)1098-2744(199707)19:2<137::Aid-Mc8>3.0.Co;2-C |
0.367 |
|
| 1997 |
Xie X, Tome ME, Gerner EW. Loss of intracellular putrescine pool-size regulation induces apoptosis. Experimental Cell Research. 230: 386-92. PMID 9024798 DOI: 10.1006/Excr.1996.3442 |
0.358 |
|
| 1996 |
Ignatenko NA, Fish JL, Shassetz LR, Woolridge DP, Gerner EW. Expression of the human spermidine/spermine N1-acetyltransferase in spermidine acetylation-deficient Escherichia coli. The Biochemical Journal. 319: 435-40. PMID 8912678 DOI: 10.1042/Bj3190435 |
0.319 |
|
| 1996 |
Meyskens FL, Gerner EW. Development of difluoromethylornithine as a chemoprevention agent for the management of colon cancer. Journal of Cellular Biochemistry. Supplement. 22: 126-31. PMID 8538189 DOI: 10.1002/Jcb.240590816 |
0.347 |
|
| 1995 |
Wu H, Rosinski S, Erdman S, Hixson L, Gerner E. Effects of non-steroidal anti-inflammatory drugs (NSAIDS) on ras mutation frequency, in colon cancers, and growth in cells expressing normal and mutant ras Cancer Genetics and Cytogenetics. 84: 151. DOI: 10.1016/0165-4608(96)85291-5 |
0.372 |
|
| 1994 |
Petereit DG, Harari PM, Contreras L, Pickart MA, Verma AK, Gerner EW, Kinsella TJ. Combining polyamine depletion with radiation therapy for rapidly dividing head and neck tumors: Strategies for improved locoregional control International Journal of Radiation Oncology, Biology, Physics. 28: 891-898. PMID 8138442 DOI: 10.1016/0360-3016(94)90109-0 |
0.338 |
|
| 1994 |
Tome ME, Fiser SM, Gerner EW. Consequences of aberrant ornithine decarboxylase regulation in rat hepatoma cells. Journal of Cellular Physiology. 158: 237-44. PMID 8106560 DOI: 10.1002/Jcp.1041580205 |
0.342 |
|
| 1994 |
Meyskens FL, Emerson SS, Pelot D, Meshkinpour H, Shassetz LR, Einspahr J, Alberts DS, Gerner EW. Dose de-escalation chemoprevention trial of α-difluoromethylornithine in patients with colon polyps Journal of the National Cancer Institute. 86: 1122-1130. PMID 8028034 DOI: 10.1093/Jnci/86.15.1122 |
0.328 |
|
| 1994 |
Wallon UM, Shassetz LR, Cress AE, Bowden GT, Gerner EW. Polyamine-dependent expression of the matrix metalloproteinase matrilysin in a human colon cancer-derived cell line. Molecular Carcinogenesis. 11: 138-44. PMID 7945802 DOI: 10.1002/Mc.2940110304 |
0.434 |
|
| 1993 |
Stea B, Buatti JM, Stringer DE, Gerner EW. Inhibition of Polyamine Synthesis Suppresses Growth and γ-Ray-Induced Sublethal and Potentially Lethal Damage Recovery in Human Tumor Cells in Culture Radiation Oncology Investigations. 1: 41-49. DOI: 10.1002/Roi.2970010108 |
0.324 |
|
| 1991 |
Carper SW, Tome ME, Fuller DJ, Chen JR, Harari PM, Gerner EW. Polyamine catabolism in rodent and human cells in culture. The Biochemical Journal. 280: 289-94. PMID 1747102 DOI: 10.1042/Bj2800289 |
0.352 |
|
| 1991 |
Buatti JM, Stea B, Stringer DE, Gerner EW. Polyamine modulation of c-myc expression and its effects on radioresponses of human glioblastoma cells (astro fellowship) International Journal of Radiation Oncology*Biology*Physics. 21: 126. DOI: 10.1016/0360-3016(91)90454-C |
0.338 |
|
| 1990 |
Harari PM, Fuller DJ, Carper SW, Croghan MK, Meyskens FL, Shimm DS, Gerner EW. Polyamine biosynthesis inhibitors combined with systemic hyperthermia in cancer therapy. International Journal of Radiation Oncology, Biology, Physics. 19: 89-96. PMID 2116388 DOI: 10.1016/0360-3016(90)90139-B |
0.369 |
|
| 1989 |
Harari PM, Tome ME, Fuller DJ, Carper SW, Gerner EW. Effects of diethyldithiocarbamate and endogenous polyamine content on cellular responses to hydrogen peroxide cytotoxicity. The Biochemical Journal. 260: 487-90. PMID 2548479 DOI: 10.1042/Bj2600487 |
0.335 |
|
| 1989 |
Harari PM, Fuller DJ, Carper SW, Croghan MK, Meyskens FL, Shimm DS, Gerner EW. Rationale for and initial clinical application of polyamine biosynthesis inhibitors combined with systemic hyperthermia in cancer therapy International Journal of Radiation Oncology*Biology*Physics. 17: 113. DOI: 10.1016/0360-3016(89)90630-5 |
0.303 |
|
| 1987 |
Glass JR, MacKrell M, Duffy JJ, Gerner EW. Ornithine decarboxylase production in vitro by using mouse cDNA. The Biochemical Journal. 245: 127-32. PMID 3663140 DOI: 10.1042/Bj2450127 |
0.318 |
|
| 1987 |
Glass JR, Gerner EW. Spermidine mediates degradation of ornithine decarboxylase by a non-lysosomal, ubiquitin-independent mechanism. Journal of Cellular Physiology. 130: 133-41. PMID 3027106 DOI: 10.1002/Jcp.1041300119 |
0.36 |
|
| 1986 |
Sertich GJ, Glass JR, Fuller DJ, Gerner EW. Altered polyamine metabolism in Chinese hamster cells growing in a defined medium. Journal of Cellular Physiology. 127: 114-20. PMID 3958058 DOI: 10.1002/Jcp.1041270115 |
0.302 |
|
| 1986 |
Shimm D, Cetas T, Sim D, Fletcher A, Bryson M, Gerner E, Cassady J. Hyperthermia in the treatment of human cancers International Journal of Radiation Oncology*Biology*Physics. 12: 153. DOI: 10.1016/0360-3016(86)90622-X |
0.335 |
|
| 1985 |
Gerner EW, Glass JR, Fuller DJ. Activation of ornithine decarboxylase in monolayer cells treated with trypsin. Journal of Cellular Physiology. 125: 567-72. PMID 3840806 DOI: 10.1002/Jcp.1041250328 |
0.352 |
|
| 1983 |
Gerner EW, Stickney DG, Herman TS, Fuller DJM. Polyamines and Polyamine Biosynthesis in Cells Exposed to Hyperthermia Radiation Research. 93: 340. DOI: 10.2307/3575990 |
0.339 |
|
| 1982 |
Gerner EW, Costa M, Holmes DK, Magun BE. Phosphorylation of nuclear and DNA-binding proteins in proliferating and quiescent mammalian cells. The Biochemical Journal. 194: 193-207. PMID 6272725 DOI: 10.1042/Bj1940193 |
0.304 |
|
| 1980 |
Cress AE, Gerner EW. Ornithine decarboxylase induction in cells stimulated to proliferate differs from that in continuously dividing cells. The Biochemical Journal. 188: 375-80. PMID 6772164 DOI: 10.1042/Bj1880375 |
0.39 |
|
| 1979 |
Cress AE, Gerner EW. Hydroxyurea inhibits ODC induction, but not the G1 to S phase transition. Biochemical and Biophysical Research Communications. 87: 773-80. PMID 454425 DOI: 10.1016/0006-291X(79)92025-4 |
0.321 |
|
| 1978 |
Cress AE, Gerner EW. Hydroxyurea treatment affects the G1 phase in next generation CHO cells. Experimental Cell Research. 110: 347-53. PMID 590360 DOI: 10.1016/0014-4827(77)90301-9 |
0.318 |
|
| 1978 |
Costa M, Gerner EW, Russell DH. Cyclic AMP levels and types I and II cyclic AMP-dependent protein kinase activity in synchronized cells and in quiescent cultures stimulated to proliferate. Biochimica Et Biophysica Acta. 538: 1-10. PMID 202331 DOI: 10.1016/0304-4165(78)90246-5 |
0.317 |
|
| 1978 |
Costa M, Fuller DJ, Russell DH, Gerner EW. Cytoplasmic and nuclear protein kinases during the cell cycle. Biochimica Et Biophysica Acta. 479: 416-26. PMID 200270 DOI: 10.1016/0005-2787(77)90035-1 |
0.323 |
|
| 1977 |
Fuller DJ, Gerner EW, Russell DH. Polyamine biosynthesis and accumulation during the G1 to S phase transition. Journal of Cellular Physiology. 93: 81-8. PMID 908741 DOI: 10.1002/Jcp.1040930111 |
0.303 |
|
| 1977 |
Connor WG, Gerner EW, Miller RC, Boone ML. Prospects for hyperthermia in human cancer therapy. Part II: implications of biological and physical data for applications of hyperthermia to man. Radiology. 123: 497-503. PMID 322208 DOI: 10.1148/123.2.497 |
0.321 |
|
| 1977 |
Leith JT, Miller RC, Gerner EW, Boone ML. Hyperthermic potentiation: biological aspects and applications to radiation therapy. Cancer. 39: 766-79. PMID 319897 DOI: 10.1002/1097-0142(197702)39:2+<766::Aid-Cncr2820390711>3.0.Co;2-5 |
0.302 |
|
| 1976 |
Gerner EW, Meyn RE, Humphrey RM. Non-histone protein synthesis during G1 phase and its relation to DNA replication. Journal of Cellular Physiology. 87: 277-87. PMID 1254652 DOI: 10.1002/Jcp.1040870303 |
0.615 |
|
| 1976 |
Costa M, Gerner EW, Russell DH. G1 specific increases in cyclic AMP levels and protein kinase activity in Chinese hamster ovary cells. Biochimica Et Biophysica Acta. 425: 246-55. PMID 175854 DOI: 10.1016/0005-2787(76)90031-9 |
0.314 |
|
| 1975 |
Gerner EW, Schneider MJ. Induced thermal resistance in HeLa cells Nature. 256: 500-502. PMID 1160994 DOI: 10.1038/256500A0 |
0.305 |
|
| 1974 |
Gerner EW, Meyn RE, Humphrey RM. The effects of ionizing radiation on the kinetics of DNA replication in synchronized Chinese hamster ovary cells. Radiation Research. 60: 62-74. PMID 10881700 DOI: 10.2307/3574006 |
0.616 |
|
| 1973 |
Gerner EW, Humphrey RM. The cell-cycle phase synthesis of non-histone proteins in mammalian cells. Biochimica Et Biophysica Acta. 331: 117-27. PMID 4796860 |
0.612 |
|
| 1973 |
Barranco SC, Gerner EW, Burk KH, Humphrey RM. Survival and cell kinetics effects of adriamycin on mammalian cells. Cancer Research. 33: 11-6. PMID 4734161 |
0.602 |
|
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