| Year |
Citation |
Score |
| 2023 |
Paterno G, Bell BM, Riley-DiPaolo A, LaVoie MJ, Giasson BI. Polymerization of recombinant tau core fragments and seeding studies in cultured cells. Frontiers in Neuroscience. 17: 1268360. PMID 38161790 DOI: 10.3389/fnins.2023.1268360 |
0.386 |
|
| 2023 |
Moore BD, Ran Y, Goodwin MS, Komatineni K, McFarland KN, Dillon K, Charles C, Ryu D, Liu X, Prokop S, Giasson BI, Golde TE, Levites Y. A C1qTNF3 collagen domain fusion chaperones diverse secreted proteins and anti-Aβ scFvs: Applications for gene therapies. Molecular Therapy. Methods & Clinical Development. 31: 101146. PMID 38027063 DOI: 10.1016/j.omtm.2023.101146 |
0.597 |
|
| 2023 |
Smith ED, Vo Q, Giasson BI, Borchelt DR, Prokop S, Chakrabarty P. Human tauopathy strains defined by phosphorylation in R1-R2 repeat domains of tau. Acta Neuropathologica Communications. 11: 172. PMID 37891635 DOI: 10.1186/s40478-023-01664-0 |
0.672 |
|
| 2023 |
Paterno G, Torrellas J, Bell BM, Gorion KM, Quintin SS, Hery GP, Prokop S, Giasson BI. Novel Conformation-Dependent Tau Antibodies Are Modulated by Adjacent Phosphorylation Sites. International Journal of Molecular Sciences. 24. PMID 37761979 DOI: 10.3390/ijms241813676 |
0.712 |
|
| 2023 |
Lloyd GM, Long B, Quintin S, Sorrentino ZA, Gorion KM, Bell BM, Carrillo D, Sullivan P, Borchelt D, Giasson BI. Carboxyl truncation of α-synuclein occurs early and is influenced by human APOE genotype in transgenic mouse models of α-synuclein pathogenesis. Acta Neuropathologica Communications. 11: 119. PMID 37482615 DOI: 10.1186/s40478-023-01623-9 |
0.338 |
|
| 2023 |
Quintin S, Lloyd GM, Paterno G, Xia Y, Sorrentino Z, Bell BM, Gorion KM, Lee EB, Prokop S, Giasson BI. Cellular processing of α-synuclein fibrils results in distinct physiological C-terminal truncations with a major cleavage site at residue Glu 114. The Journal of Biological Chemistry. 104912. PMID 37307916 DOI: 10.1016/j.jbc.2023.104912 |
0.749 |
|
| 2023 |
Xia Y, Bell BM, Kim JD, Giasson BI. Tau mutation S356T in the three repeat isoform leads to microtubule dysfunction and promotes prion-like seeded aggregation. Frontiers in Neuroscience. 17: 1181804. PMID 37304025 DOI: 10.3389/fnins.2023.1181804 |
0.313 |
|
| 2023 |
Xia Y, Bell BM, Giasson BI. Tau Lysine Pseudomethylation Regulates Microtubule Binding and Enhances Prion-like Tau Aggregation. International Journal of Molecular Sciences. 24. PMID 37175990 DOI: 10.3390/ijms24098286 |
0.711 |
|
| 2022 |
Croft CL, Paterno G, Vause AR, Rowe LA, Ryu DH, Goodwin MS, Moran CA, Cruz PE, Giasson BI, Golde TE. Optical pulse labeling studies reveal exogenous seeding slows α-synuclein clearance. Npj Parkinson's Disease. 8: 173. PMID 36535953 DOI: 10.1038/s41531-022-00434-4 |
0.302 |
|
| 2022 |
Paterno G, Bell BM, Gorion KM, Prokop S, Giasson BI. Reassessment of Neuronal Tau Distribution in Adult Human Brain and Implications for Tau Pathobiology. Acta Neuropathologica Communications. 10: 94. PMID 35765058 DOI: 10.1186/s40478-022-01394-9 |
0.733 |
|
| 2022 |
Sorrentino ZA, Hass E, Vijayaraghavan N, Gorion KM, Riffe CJ, Dhillon JS, Giasson BI. Corrigendum to "Carboxy-terminal truncation and phosphorylation of α-synuclein elongates survival in a prion-like seeding mouse model of synucleinopathy" [Neurosci. Lett. 732 (2020) 1-11/135017]. Neuroscience Letters. 783: 136719. PMID 35717861 DOI: 10.1016/j.neulet.2022.136719 |
0.719 |
|
| 2022 |
Xia Y, Prokop S, Bell BM, Gorion KM, Croft CL, Nasif L, Xu G, Riffe CJ, Manaois AN, Strang KH, Quintin SS, Paterno G, Tansey MG, Borchelt DR, Golde TE, ... Giasson BI, et al. Pathogenic tau recruits wild-type tau into brain inclusions and induces gut degeneration in transgenic SPAM mice. Communications Biology. 5: 446. PMID 35550593 DOI: 10.1038/s42003-022-03373-1 |
0.828 |
|
| 2022 |
Moore BD, Levites Y, Xu G, Hampton H, Adamo MF, Croft CL, Futch HS, Moran C, Fromholt S, Janus C, Prokop S, Dickson D, Lewis J, Giasson BI, Golde TE, et al. Soluble brain homogenates from diverse human and mouse sources preferentially seed diffuse Aβ plaque pathology when injected into newborn mouse hosts. Free Neuropathology. 3. PMID 35494163 DOI: 10.17879/freeneuropathology-2022-3766 |
0.73 |
|
| 2022 |
Lloyd GM, Sorrentino ZA, Quintin S, Gorion KM, Bell BM, Paterno G, Long B, Prokop S, Giasson BI. Unique seeding profiles and prion-like propagation of synucleinopathies are highly dependent on the host in human α-synuclein transgenic mice. Acta Neuropathologica. PMID 35488930 DOI: 10.1007/s00401-022-02425-4 |
0.829 |
|
| 2022 |
Williams T, Ruiz AJ, Ruiz AM, Vo Q, Tsering W, Xu G, McFarland K, Giasson BI, Sullivan P, Borchelt DR, Chakrabarty P. Impact of APOE genotype on prion-type propagation of tauopathy. Acta Neuropathologica Communications. 10: 57. PMID 35440098 DOI: 10.1186/s40478-022-01359-y |
0.317 |
|
| 2021 |
Xia Y, Lloyd GM, Giasson BI. Targeted proteolytic products of τ and α-synuclein in neurodegeneration. Essays in Biochemistry. 65: 905-912. PMID 34846537 DOI: 10.1042/EBC20210028 |
0.826 |
|
| 2021 |
Koller EJ, Ibanez KR, Vo Q, McFarland KN, Gonzalez De La Cruz E, Zobel L, Williams T, Xu G, Ryu D, Patel P, Giasson BI, Prokop S, Chakrabarty P. Combinatorial model of amyloid β and tau reveals synergy between amyloid deposits and tangle formation. Neuropathology and Applied Neurobiology. PMID 34825397 DOI: 10.1111/nan.12779 |
0.719 |
|
| 2021 |
Lloyd GM, Dhillon JS, Gorion KM, Riffe C, Fromholt SE, Xia Y, Giasson BI, Borchelt DR. Collusion of α-Synuclein and Aβ aggravating co-morbidities in a novel prion-type mouse model. Molecular Neurodegeneration. 16: 63. PMID 34503546 DOI: 10.1186/s13024-021-00486-9 |
0.838 |
|
| 2021 |
Hass EW, Sorrentino ZA, Xia Y, Lloyd GM, Trojanowski JQ, Prokop S, Giasson BI. Disease-, region- and cell type specific diversity of α-synuclein carboxy terminal truncations in synucleinopathies. Acta Neuropathologica Communications. 9: 146. PMID 34454615 DOI: 10.1186/s40478-021-01242-2 |
0.832 |
|
| 2021 |
Xia Y, Bell BM, Giasson BI. Tau K321/K353 pseudoacetylation within KXGS motifs regulates tau-microtubule interactions and inhibits aggregation. Scientific Reports. 11: 17069. PMID 34426645 DOI: 10.1038/s41598-021-96627-7 |
0.744 |
|
| 2021 |
Dagra A, Miller DR, Lin M, Gopinath A, Shaerzadeh F, Harris S, Sorrentino ZA, Støier JF, Velasco S, Azar J, Alonge AR, Lebowitz JJ, Ulm B, Bu M, Hansen CA, ... ... Giasson BI, et al. α-Synuclein-induced dysregulation of neuronal activity contributes to murine dopamine neuron vulnerability. Npj Parkinson's Disease. 7: 76. PMID 34408150 DOI: 10.1038/s41531-021-00210-w |
0.723 |
|
| 2021 |
Ferreira N, Richner M, van der Laan A, Bergholdt Jul Christiansen I, Vægter CB, Nyengaard JR, Halliday GM, Weiss J, Giasson BI, Mackenzie IR, Jensen PH, Jan A. Prodromal neuroinvasion of pathological α-synuclein in brainstem reticular nuclei and white matter lesions in a model of α-synucleinopathy. Brain Communications. 3: fcab104. PMID 34136810 DOI: 10.1093/braincomms/fcab104 |
0.303 |
|
| 2021 |
Ferreira N, Richner M, van der Laan A, Bergholdt Jul Christiansen I, Vægter CB, Nyengaard JR, Halliday GM, Weiss J, Giasson BI, Mackenzie IR, Jensen PH, Jan A. Prodromal neuroinvasion of pathological α-synuclein in brainstem reticular nuclei and white matter lesions in a model of α-synucleinopathy. Brain Communications. 3: fcab104. PMID 34136810 DOI: 10.1093/braincomms/fcab104 |
0.303 |
|
| 2021 |
Xia Y, Prokop S, Giasson BI. "Don't Phos Over Tau": recent developments in clinical biomarkers and therapies targeting tau phosphorylation in Alzheimer's disease and other tauopathies. Molecular Neurodegeneration. 16: 37. PMID 34090488 DOI: 10.1186/s13024-021-00460-5 |
0.815 |
|
| 2021 |
Ferreira N, Gram H, Sorrentino ZA, Gregersen E, Schmidt SI, Reimer L, Betzer C, Perez-Gozalbo C, Beltoja M, Nagaraj M, Wang J, Nowak JS, Dong M, Willén K, Cholak E, ... ... Giasson BI, et al. Multiple system atrophy-associated oligodendroglial protein p25α stimulates formation of novel α-synuclein strain with enhanced neurodegenerative potential. Acta Neuropathologica. PMID 33978813 DOI: 10.1007/s00401-021-02316-0 |
0.74 |
|
| 2021 |
Hass EW, Sorrentino ZA, Lloyd GM, McFarland NR, Prokop S, Giasson BI. Robust α-synuclein pathology in select brainstem neuronal populations is a potential instigator of multiple system atrophy. Acta Neuropathologica Communications. 9: 80. PMID 33941284 DOI: 10.1186/s40478-021-01173-y |
0.832 |
|
| 2021 |
Krumm ZA, Lloyd GM, Francis CP, Nasif LH, Mitchell DA, Golde TE, Giasson BI, Xia Y. Precision therapeutic targets for COVID-19. Virology Journal. 18: 66. PMID 33781287 DOI: 10.1186/s12985-021-01526-y |
0.767 |
|
| 2021 |
Xia Y, Nasif L, Giasson BI. Pathogenic MAPT mutations Q336H and Q336R have isoform-dependent differences in aggregation propensity and microtubule dysfunction. Journal of Neurochemistry. PMID 33772783 DOI: 10.1111/jnc.15358 |
0.713 |
|
| 2021 |
Croft CL, Goodwin MS, Ryu DH, Lessard CB, Tejeda G, Marrero M, Vause AR, Paterno G, Cruz PE, Lewis J, Giasson BI, Golde TE. Photodynamic studies reveal rapid formation and appreciable turnover of tau inclusions. Acta Neuropathologica. PMID 33496840 DOI: 10.1007/s00401-021-02264-9 |
0.354 |
|
| 2021 |
Xia Y, Chen Z, Xu G, Borchelt DR, Ayers JI, Giasson BI. Novel SOD1 monoclonal antibodies against the electrostatic loop preferentially detect misfolded SOD1 aggregates. Neuroscience Letters. 742: 135553. PMID 33346076 DOI: 10.1016/j.neulet.2020.135553 |
0.669 |
|
| 2020 |
Henrich MT, Geibl FF, Lakshminarasimhan H, Stegmann A, Giasson BI, Mao X, Dawson VL, Dawson TM, Oertel WH, Surmeier DJ. Determinants of seeding and spreading of α-synuclein pathology in the brain. Science Advances. 6. PMID 33177086 DOI: 10.1126/sciadv.abc2487 |
0.326 |
|
| 2020 |
Goodwin MS, Sinyavskaya O, Burg F, O'Neal V, Ceballos-Diaz C, Cruz PE, Lewis J, Giasson BI, Davies P, Golde TE, Levites Y. Anti-tau scFvs Targeted to the Cytoplasm or Secretory Pathway Variably Modify Pathology and Neurodegenerative Phenotypes. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 33128896 DOI: 10.1016/j.ymthe.2020.10.007 |
0.332 |
|
| 2020 |
Williams T, Sorrentino Z, Weinrich M, Giasson BI, Chakrabarty P. Differential cross-seeding properties of tau and α-synuclein in mouse models of tauopathy and synucleinopathy. Brain Communications. 2: fcaa090. PMID 33094280 DOI: 10.1093/braincomms/fcaa090 |
0.767 |
|
| 2020 |
Trejo-Lopez JA, Sorrentino ZA, Riffe CJ, Lloyd GM, Labuzan SA, Dickson DW, Yachnis AT, Prokop S, Giasson BI. Novel Monoclonal Antibodies Targeting the RRM2 domain of Human TDP-43 Protein. Neuroscience Letters. 135353. PMID 32905837 DOI: 10.1016/J.Neulet.2020.135353 |
0.807 |
|
| 2020 |
Butkovich LM, Houser MC, Chalermpalanupap T, Porter-Stransky KA, Iannitelli AF, Boles JS, Lloyd GM, Coomes AS, Eidson LN, De Sousa Rodrigues ME, Oliver DL, Kelly SD, Chang J, Bengoa-Vergniory N, Wade-Martins R, ... Giasson BI, et al. Transgenic mice expressing human alpha-synuclein in noradrenergic neurons develop locus coeruleus pathology and non-motor features of Parkinson's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 32868457 DOI: 10.1523/Jneurosci.1468-19.2020 |
0.818 |
|
| 2020 |
Chu WT, DeSimone JC, Riffe CJ, Liu H, Chakrabarty P, Giasson BI, Vedam-Mai V, Vaillancourt DE. Alpha-synuclein induces progressive changes in brain microstructure and sensory-evoked brain function that precedes locomotor decline. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 32669353 DOI: 10.1523/Jneurosci.0189-20.2020 |
0.413 |
|
| 2020 |
Xia Y, Prokop S, Gorion KM, Kim JD, Sorrentino ZA, Bell BM, Manaois AN, Chakrabarty P, Davies P, Giasson BI. Tau Ser208 phosphorylation promotes aggregation and reveals neuropathologic diversity in Alzheimer's disease and other tauopathies. Acta Neuropathologica Communications. 8: 88. PMID 32571418 DOI: 10.1186/S40478-020-00967-W |
0.831 |
|
| 2020 |
Sorrentino ZA, Giasson BI. The emerging role of α-synuclein truncation in aggregation and disease. The Journal of Biological Chemistry. PMID 32424039 DOI: 10.1074/Jbc.Rev120.011743 |
0.794 |
|
| 2020 |
Sorrentino ZA, Hass E, Vijayaraghavan N, Gorion KM, Riffe CJ, Dhillon JS, Giasson BI. Carboxy-terminal truncation and phosphorylation of α-synuclein elongates survival in a prion-like seeding mouse model of synucleinopathy. Neuroscience Letters. 135017. PMID 32371157 DOI: 10.1016/J.Neulet.2020.135017 |
0.781 |
|
| 2020 |
Lloyd GM, Trejo-Lopez JA, Xia Y, McFarland KN, Lincoln SJ, Ertekin-Taner N, Giasson BI, Yachnis AT, Prokop S. Prominent amyloid plaque pathology and cerebral amyloid angiopathy in APP V717I (London) carrier - phenotypic variability in autosomal dominant Alzheimer's disease. Acta Neuropathologica Communications. 8: 31. PMID 32164763 DOI: 10.1186/S40478-020-0891-3 |
0.809 |
|
| 2020 |
Trejo-Lopez JA, Sorrentino ZA, Riffe CJ, Prokop S, Dickson DW, Yachnis AT, Giasson BI. Generation and Characterization of Novel Monoclonal Antibodies Targeting p62/sequestosome-1 Across Human Neurodegenerative Diseases. Journal of Neuropathology and Experimental Neurology. PMID 32106300 DOI: 10.1093/Jnen/Nlaa007 |
0.817 |
|
| 2020 |
Sorrentino ZA, Xia Y, Gorion KM, Hass E, Giasson BI. Carboxy-terminal truncations of mouse alpha-synuclein alter aggregation and prion-like seeding. Febs Letters. PMID 31912891 DOI: 10.1002/1873-3468.13728 |
0.843 |
|
| 2019 |
Sacino AN, Prokop S, Walsh MA, Adamson J, Subramony SH, Krans A, Todd PK, Giasson BI, Yachnis AT. Fragile X-associated tremor ataxia syndrome with co-occurrent progressive supranuclear palsy-like neuropathology. Acta Neuropathologica Communications. 7: 158. PMID 31665069 DOI: 10.1186/S40478-019-0818-Z |
0.823 |
|
| 2019 |
Xia Y, Sorrentino ZA, Kim JD, Strang KH, Riffe CJ, Giasson BI. Impaired tau-microtubule interactions are prevalent among pathogenic tau variants arising from missense mutations. The Journal of Biological Chemistry. PMID 31653695 DOI: 10.1074/Jbc.Ra119.010178 |
0.83 |
|
| 2019 |
Mavroeidi P, Arvanitaki F, Karakitsou AK, Vetsi M, Kloukina I, Zweckstetter M, Giller K, Becker S, Sorrentino ZA, Giasson BI, Jensen PH, Stefanis L, Xilouri M. Correction to: Endogenous oligodendroglial alpha-synuclein and TPPP/p25α orchestrate alpha-synuclein pathology in experimental multiple system atrophy models. Acta Neuropathologica. PMID 31485733 DOI: 10.1007/s00401-019-02068-y |
0.718 |
|
| 2019 |
Sorrentino ZA, Goodwin MS, Riffe CJ, Dhillon JS, Xia Y, Gorion KM, Vijayaraghavan N, McFarland KN, Golbe LI, Yachnis AT, Giasson BI. Unique α-synuclein pathology within the amygdala in Lewy body dementia: implications for disease initiation and progression. Acta Neuropathologica Communications. 7: 142. PMID 31477175 DOI: 10.1186/S40478-019-0787-2 |
0.84 |
|
| 2019 |
Sorrentino ZA, Giasson BI. Exploring the Peripheral Initiation of Parkinson's Disease in Animal Models. Neuron. 103: 547-549. PMID 31437447 DOI: 10.1016/J.Neuron.2019.07.031 |
0.759 |
|
| 2019 |
Koller EJ, De La Cruz EG, Machula T, Ibanez KR, Lin WL, Williams T, Riffe CJ, Ryu D, Strang KH, Liu X, Janus C, Golde TE, Dickson D, Giasson BI, Chakrabarty P. Combining P301L and S320F tau variants produces a novel accelerated model of tauopathy. Human Molecular Genetics. PMID 31261380 DOI: 10.1093/Hmg/Ddz151 |
0.458 |
|
| 2019 |
Dhillon JS, Trejo-Lopez JA, Riffe C, Levites Y, Sacino AN, Borchelt DR, Yachnis AY, Giasson BI. Comparative analyses of the in vivo induction and transmission of α-synuclein pathology in transgenic mice by MSA brain lysate and recombinant α-synuclein fibrils. Acta Neuropathologica Communications. 7: 80. PMID 31109378 DOI: 10.1186/S40478-019-0733-3 |
0.78 |
|
| 2019 |
Mavroeidi P, Arvanitaki F, Karakitsou AK, Vetsi M, Kloukina I, Zweckstetter M, Giller K, Becker S, Sorrentino ZA, Giasson BI, Jensen PH, Stefanis L, Xilouri M. Endogenous oligodendroglial alpha-synuclein and TPPP/p25α orchestrate alpha-synuclein pathology in experimental multiple system atrophy models. Acta Neuropathologica. PMID 31011860 DOI: 10.1007/S00401-019-02014-Y |
0.789 |
|
| 2019 |
Sorrentino ZA, Giasson BI, Chakrabarty P. α-Synuclein and astrocytes: tracing the pathways from homeostasis to neurodegeneration in Lewy body disease. Acta Neuropathologica. PMID 30798354 DOI: 10.1007/S00401-019-01977-2 |
0.755 |
|
| 2019 |
Croft CL, Cruz PE, Ryu DH, Ceballos-Diaz C, Strang KH, Woody BM, Lin WL, Deture M, Rodríguez-Lebrón E, Dickson DW, Chakrabarty P, Levites Y, Giasson BI, Golde TE. rAAV-based brain slice culture models of Alzheimer's and Parkinson's disease inclusion pathologies. The Journal of Experimental Medicine. PMID 30770411 DOI: 10.1084/Jem.20182184 |
0.48 |
|
| 2019 |
Strang KH, Golde TE, Giasson BI. MAPT mutations, tauopathy, and mechanisms of neurodegeneration. Laboratory Investigation; a Journal of Technical Methods and Pathology. PMID 30742061 DOI: 10.1038/S41374-019-0197-X |
0.494 |
|
| 2019 |
Dhillon JS, Trejo-Lopez JA, Riffe C, McFarland NR, Hiser WM, Giasson BI, Yachnis AT. Dissecting α-synuclein inclusion pathology diversity in multiple system atrophy: implications for the prion-like transmission hypothesis. Laboratory Investigation; a Journal of Technical Methods and Pathology. PMID 30737468 DOI: 10.1038/S41374-019-0198-9 |
0.511 |
|
| 2018 |
Strang KH, Sorrentino ZA, Riffe CJ, Gorion KM, Vijayaraghavan N, Golde TE, Giasson BI. Phosphorylation of serine 305 in tau inhibits aggregation. Neuroscience Letters. 692: 187-192. PMID 30423399 DOI: 10.1016/J.Neulet.2018.11.011 |
0.778 |
|
| 2018 |
Sorrentino ZA, Vijayaraghavan N, Gorion KM, Riffe CJ, Strang KH, Caldwell J, Giasson BI. Physiological carboxy-truncation of α-synuclein potentiates the prion-like formation of pathological inclusions. The Journal of Biological Chemistry. PMID 30327435 DOI: 10.1074/Jbc.Ra118.005603 |
0.761 |
|
| 2018 |
Hamm M, Ladd TB, Levites Y, Golde TE, Giasson BI, Lewis J. Designing antibodies against LRRK2-targeted tau epitopes. Plos One. 13: e0204367. PMID 30261006 DOI: 10.1371/Journal.Pone.0204367 |
0.436 |
|
| 2018 |
Sorrentino ZA, Xia Y, Funk C, Riffe CJ, Rutherford NJ, Diaz CC, Sacino AN, Price ND, Golde TE, Giasson BI, Chakrabarty P. Motor neuron loss and neuroinflammation in a model of α-synuclein-induced neurodegeneration. Neurobiology of Disease. PMID 30195075 DOI: 10.1016/J.Nbd.2018.09.005 |
0.809 |
|
| 2018 |
Chakrabarty P, Li A, Ladd TB, Strickland MR, Koller EJ, Burgess JD, Funk CC, Cruz PE, Allen M, Yaroshenko M, Wang X, Younkin C, Reddy J, Lohrer B, Mehrke L, ... ... Giasson BI, et al. TLR5 decoy receptor as a novel anti-amyloid therapeutic for Alzheimer's disease. The Journal of Experimental Medicine. PMID 30158114 DOI: 10.1084/Jem.20180484 |
0.358 |
|
| 2018 |
Pace MC, Xu G, Fromholt S, Howard J, Crosby K, Giasson BI, Lewis J, Borchelt DR. Changes in proteome solubility indicate widespread proteostatic disruption in mouse models of neurodegenerative disease. Acta Neuropathologica. PMID 30140941 DOI: 10.1007/S00401-018-1895-Y |
0.477 |
|
| 2018 |
Ayers JI, Riffe CJ, Sorrentino ZA, Diamond J, Fagerli E, Brooks M, Galaleldeen A, Hart PJ, Giasson BI. Localized induction of wild-type and mutant alpha-synuclein aggregation reveals propagation along neuroanatomical tracts. Journal of Virology. PMID 29976670 DOI: 10.1128/Jvi.00586-18 |
0.772 |
|
| 2018 |
Rayaprolu S, Seven YB, Howard J, Duffy C, Altshuler M, Moloney C, Giasson BI, Lewis J. Partial loss of ATP13A2 causes selective gliosis independent of robust lipofuscinosis. Molecular and Cellular Neurosciences. PMID 29859891 DOI: 10.1016/J.Mcn.2018.05.009 |
0.432 |
|
| 2018 |
Pace MC, Xu G, Fromholt S, Howard J, Giasson BI, Lewis J, Borchelt DR. Differential induction of mutant SOD1 misfolding and aggregation by tau and α-synuclein pathology. Molecular Neurodegeneration. 13: 23. PMID 29776378 DOI: 10.1186/S13024-018-0253-9 |
0.436 |
|
| 2018 |
Croft CL, Moore BD, Ran Y, Chakrabarty P, Levites Y, Golde TE, Giasson BI. Novel monoclonal antibodies targeting the microtubule-binding domain of human tau. Plos One. 13: e0195211. PMID 29608591 DOI: 10.1371/Journal.Pone.0195211 |
0.473 |
|
| 2018 |
Strang KH, Croft CL, Sorrentino ZA, Chakrabarty P, Golde TE, Giasson BI. Distinct differences in prion-like seeding and aggregation between Tau protein variants provide mechanistic insights into tauopathies. The Journal of Biological Chemistry. 293: 4579. PMID 29572329 DOI: 10.1074/jbc.AAC118.002657 |
0.743 |
|
| 2018 |
Phan HTM, Bartz JC, Ayers J, Giasson BI, Schubert M, Rodenhausen KB, Kananizadeh N, Li Y, Bartelt-Hunt SL. Adsorption and decontamination of α-synuclein from medically and environmentally-relevant surfaces. Colloids and Surfaces. B, Biointerfaces. 166: 98-107. PMID 29550546 DOI: 10.1016/J.Colsurfb.2018.03.011 |
0.326 |
|
| 2018 |
Giraldo G, Brooks M, Giasson BI, Janus C. Locomotor differences in mice expressing wild-type human α-synuclein. Neurobiology of Aging. 65: 140-148. PMID 29477894 DOI: 10.1016/J.Neurobiolaging.2018.01.020 |
0.424 |
|
| 2017 |
Strang KH, Croft CL, Sorrentino ZA, Chakrabarty P, Golde TE, Giasson BI. Distinct differences in prion-like seeding and aggregation between tau protein variants provide mechanistic insights into tauopathies. The Journal of Biological Chemistry. PMID 29259137 DOI: 10.1074/Jbc.M117.815357 |
0.789 |
|
| 2017 |
Tayebi N, Parisiadou L, Berhe B, Gonzalez AN, Serra-Vinardell J, Tamargo RJ, Maniwang E, Sorrentino Z, Fujiwara H, Grey RJ, Hassan S, Blech-Hermoni YN, Chen C, McGlinchey R, Makariou-Pikis C, ... ... Giasson BI, et al. Glucocerebrosidase haploinsufficiency in A53T α-synuclein mice impacts disease onset and course. Molecular Genetics and Metabolism. 122: 198-208. PMID 29173981 DOI: 10.1016/J.Ymgme.2017.11.001 |
0.766 |
|
| 2017 |
Rutherford NJ, Dhillon JS, Riffe CJ, Howard JK, Brooks M, Giasson BI. Comparison of the in vivo induction and transmission of α-synuclein pathology by mutant α-synuclein fibril seeds in transgenic mice. Human Molecular Genetics. PMID 29036344 DOI: 10.1093/Hmg/Ddx371 |
0.434 |
|
| 2017 |
Rutherford NJ, Brooks M, Riffe CJ, Gorion KM, Howard JK, Dhillon JS, Giasson BI. Prion-like transmission of α-synuclein pathology in the context of an NFL null background. Neuroscience Letters. PMID 28964772 DOI: 10.1016/J.Neulet.2017.09.054 |
0.456 |
|
| 2017 |
Dhillon JS, Riffe C, Moore BD, Ran Y, Chakrabarty P, Golde TE, Giasson BI. A novel panel of α-synuclein antibodies reveal distinctive staining profiles in synucleinopathies. Plos One. 12: e0184731. PMID 28910367 DOI: 10.1371/Journal.Pone.0184731 |
0.447 |
|
| 2017 |
Park HJ, Ryu D, Parmar M, Giasson BI, McFarland NR. The ER retention protein RER1 promotes alpha-synuclein degradation via the proteasome. Plos One. 12: e0184262. PMID 28877262 DOI: 10.1371/Journal.Pone.0184262 |
0.453 |
|
| 2017 |
Strang KH, Goodwin MS, Riffe C, Moore BD, Chakrabarty P, Levites Y, Golde TE, Giasson BI. Generation and characterization of new monoclonal antibodies targeting the PHF1 and AT8 epitopes on human tau. Acta Neuropathologica Communications. 5: 58. PMID 28760159 DOI: 10.1186/S40478-017-0458-0 |
0.487 |
|
| 2017 |
Sorrentino ZA, Brooks MMT, Hudson V, Rutherford NJ, Golde TE, Giasson BI, Chakrabarty P. Intrastriatal injection of α-synuclein can lead to widespread synucleinopathy independent of neuroanatomic connectivity. Molecular Neurodegeneration. 12: 40. PMID 28552073 DOI: 10.1186/S13024-017-0182-Z |
0.757 |
|
| 2017 |
Ayers JI, Giasson BI, Borchelt DR. Prion-like Spreading in Tauopathies. Biological Psychiatry. PMID 28506438 DOI: 10.1016/J.Biopsych.2017.04.003 |
0.493 |
|
| 2017 |
Koller EJ, Brooks MM, Golde TE, Giasson BI, Chakrabarty P. Inflammatory pre-conditioning restricts the seeded induction of α-synuclein pathology in wild type mice. Molecular Neurodegeneration. 12: 1. PMID 28049533 DOI: 10.1186/S13024-016-0142-Z |
0.379 |
|
| 2017 |
Croft CL, Cruz PE, Goodwin MS, Ceballos-Diaz C, Strang K, Chakrabarty P, Levites Y, Giasson BI, Golde TE. [P4-094]: TARGETING TAU AGGREGATION IN BRAIN SLICE CULTURE MODELS OF TAUOPATHIES Alzheimer's & Dementia. 13: P1294-P1294. DOI: 10.1016/J.Jalz.2017.06.1959 |
0.354 |
|
| 2016 |
Ayers JI, Brooks MM, Rutherford NJ, Howard JK, Sorrentino ZA, Riffe CJ, Giasson BI. Robust CNS pathology in transgenic mice following peripheral injection of α-synuclein fibrils. Journal of Virology. PMID 27852849 DOI: 10.1128/Jvi.02095-16 |
0.748 |
|
| 2016 |
Rutherford NJ, Brooks M, Giasson BI. Novel antibodies to phosphorylated α-synuclein serine 129 and NFL serine 473 demonstrate the close molecular homology of these epitopes. Acta Neuropathologica Communications. 4: 80. PMID 27503460 DOI: 10.1186/S40478-016-0357-9 |
0.366 |
|
| 2016 |
Sacino AN, Brooks MM, Chakrabarty P, Saha K, Khoshbouei H, Golde TE, Giasson BI. Proteolysis of α-Synuclein Fibrils in the Lysosomal Pathway Limits Induction of Inclusion Pathology. Journal of Neurochemistry. PMID 27424880 DOI: 10.1111/Jnc.13743 |
0.77 |
|
| 2015 |
Uchihara T, Giasson BI, Paulus W. Propagation of Aβ, tau and α-synuclein pathology between experimental models and human reality: prions, propagons and propaganda. Acta Neuropathologica. PMID 26715564 DOI: 10.1007/S00401-015-1517-X |
0.454 |
|
| 2015 |
Sacino AN, Ayers JI, Brooks MM, Chakrabarty P, Hudson VJ, Howard JK, Golde TE, Giasson BI, Borchelt DR. Non-prion-type transmission in A53T α-synuclein transgenic mice: a normal component of spinal homogenates from naïve non-transgenic mice induces robust α-synuclein pathology. Acta Neuropathologica. PMID 26541429 DOI: 10.1007/S00401-015-1505-1 |
0.746 |
|
| 2015 |
Uchihara T, Giasson BI. Propagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies. Acta Neuropathologica. PMID 26446103 DOI: 10.1007/S00401-015-1485-1 |
0.453 |
|
| 2015 |
Rutherford NJ, Sacino AN, Brooks M, Ceballos-Diaz C, Ladd TB, Howard JK, Golde TE, Giasson BI. Studies of lipopolysaccharide effects on the induction of α-synuclein pathology by exogenous fibrils in transgenic mice. Molecular Neurodegeneration. 10: 32. PMID 26223783 DOI: 10.1186/S13024-015-0029-4 |
0.758 |
|
| 2015 |
Hamm M, Bailey R, Shaw G, Yen SH, Lewis J, Giasson BI. Physiologically relevant factors influence tau phosphorylation by leucine-rich repeat kinase 2. Journal of Neuroscience Research. PMID 26123245 DOI: 10.1002/Jnr.23614 |
0.449 |
|
| 2015 |
Chakrabarty P, Hudson Iii VJ, Sacino AN, Brooks MM, D'Alton S, Lewis J, Golde TE, Giasson BI. Inefficient induction and spread of seeded tau pathology in P301L mouse model of tauopathy suggests inherent physiological barriers to transmission. Acta Neuropathologica. 130: 303-5. PMID 25982997 DOI: 10.1007/S00401-015-1444-X |
0.778 |
|
| 2015 |
Rutherford NJ, Giasson BI. The A53E α-synuclein pathological mutation demonstrates reduced aggregation propensity in vitro and in cell culture. Neuroscience Letters. 597: 43-8. PMID 25892596 DOI: 10.1016/J.Neulet.2015.04.022 |
0.404 |
|
| 2015 |
Chakrabarty P, Brooks M, Hudson V, Levites Y, Giasson BI, Golde T. O2-05-01: IL-10 modifies disease progression and pathology in a mouse model of alpha synucleinopathy Alzheimer's & Dementia. 11: P182-P183. DOI: 10.1016/J.Jalz.2015.07.154 |
0.355 |
|
| 2014 |
Fishbein I, Kuo YM, Giasson BI, Nussbaum RL. Augmentation of phenotype in a transgenic Parkinson mouse heterozygous for a Gaucher mutation. Brain : a Journal of Neurology. 137: 3235-47. PMID 25351739 DOI: 10.1093/Brain/Awu291 |
0.441 |
|
| 2014 |
Sacino AN, Brooks M, McKinney AB, Thomas MA, Shaw G, Golde TE, Giasson BI. Brain injection of α-synuclein induces multiple proteinopathies, gliosis, and a neuronal injury marker. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 12368-78. PMID 25209277 DOI: 10.1523/Jneurosci.2102-14.2014 |
0.768 |
|
| 2014 |
Sacino AN, Brooks M, Thomas MA, McKinney AB, Lee S, Regenhardt RW, McGarvey NH, Ayers JI, Notterpek L, Borchelt DR, Golde TE, Giasson BI. Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 111: 10732-7. PMID 25002524 DOI: 10.1073/Pnas.1321785111 |
0.771 |
|
| 2014 |
Rutherford NJ, Moore BD, Golde TE, Giasson BI. Divergent effects of the H50Q and G51D SNCA mutations on the aggregation of α-synuclein. Journal of Neurochemistry. 131: 859-67. PMID 24984882 DOI: 10.1111/Jnc.12806 |
0.445 |
|
| 2014 |
Guo L, Giasson BI, Glavis-Bloom A, Brewer MD, Shorter J, Gitler AD, Yang X. A cellular system that degrades misfolded proteins and protects against neurodegeneration. Molecular Cell. 55: 15-30. PMID 24882209 DOI: 10.1016/J.Molcel.2014.04.030 |
0.363 |
|
| 2014 |
Sacino AN, Brooks M, Thomas MA, McKinney AB, McGarvey NH, Rutherford NJ, Ceballos-Diaz C, Robertson J, Golde TE, Giasson BI. Amyloidogenic α-synuclein seeds do not invariably induce rapid, widespread pathology in mice. Acta Neuropathologica. 127: 645-65. PMID 24659240 DOI: 10.1007/S00401-014-1268-0 |
0.755 |
|
| 2014 |
Escobar VD, Kuo YM, Orrison BM, Giasson BI, Nussbaum RL. Transgenic mice expressing S129 phosphorylation mutations in α-synuclein. Neuroscience Letters. 563: 96-100. PMID 24486885 DOI: 10.1016/J.Neulet.2014.01.033 |
0.472 |
|
| 2014 |
Gould N, Mor DE, Lightfoot R, Malkus K, Giasson B, Ischiropoulos H. Evidence of native α-synuclein conformers in the human brain Journal of Biological Chemistry. 289: 7929-7934. PMID 24474688 DOI: 10.1074/Jbc.C113.538249 |
0.36 |
|
| 2014 |
Ren Y, Sahara N, Giasson B, Lewis J. Tauopathy Mouse Models Movement Disorders: Genetics and Models: Second Edition. 849-855. DOI: 10.1016/B978-0-12-405195-9.00055-X |
0.397 |
|
| 2013 |
Musiek ES, Lim MM, Yang G, Bauer AQ, Qi L, Lee Y, Roh JH, Ortiz-Gonzalez X, Dearborn JT, Culver JP, Herzog ED, Hogenesch JB, Wozniak DF, Dikranian K, Giasson BI, et al. Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration. The Journal of Clinical Investigation. 123: 5389-400. PMID 24270424 DOI: 10.1172/Jci70317 |
0.333 |
|
| 2013 |
Sacino AN, Brooks M, McGarvey NH, McKinney AB, Thomas MA, Levites Y, Ran Y, Golde TE, Giasson BI. Induction of CNS α-synuclein pathology by fibrillar and non-amyloidogenic recombinant α-synuclein. Acta Neuropathologica Communications. 1: 38. PMID 24252149 DOI: 10.1186/2051-5960-1-38 |
0.784 |
|
| 2013 |
Bailey RM, Covy JP, Melrose HL, Rousseau L, Watkinson R, Knight J, Miles S, Farrer MJ, Dickson DW, Giasson BI, Lewis J. LRRK2 phosphorylates novel tau epitopes and promotes tauopathy. Acta Neuropathologica. 126: 809-27. PMID 24113872 DOI: 10.1007/S00401-013-1188-4 |
0.815 |
|
| 2013 |
Rutherford NJ, Lewis J, Clippinger AK, Thomas MA, Adamson J, Cruz PE, Cannon A, Xu G, Golde TE, Shaw G, Borchelt DR, Giasson BI. Unbiased screen reveals ubiquilin-1 and -2 highly associated with huntingtin inclusions. Brain Research. 1524: 62-73. PMID 23774650 DOI: 10.1016/J.Brainres.2013.06.006 |
0.509 |
|
| 2013 |
Sacino AN, Thomas MA, Ceballos-Diaz C, Cruz PE, Rosario AM, Lewis J, Giasson BI, Golde TE. Conformational templating of α-synuclein aggregates in neuronal-glial cultures. Molecular Neurodegeneration. 8: 17. PMID 23714769 DOI: 10.1186/1750-1326-8-17 |
0.776 |
|
| 2013 |
Clippinger AK, D'Alton S, Lin WL, Gendron TF, Howard J, Borchelt DR, Cannon A, Carlomagno Y, Chakrabarty P, Cook C, Golde TE, Levites Y, Ranum L, Schultheis PJ, Xu G, ... ... Giasson B, et al. Robust cytoplasmic accumulation of phosphorylated TDP-43 in transgenic models of tauopathy. Acta Neuropathologica. 126: 39-50. PMID 23666556 DOI: 10.1007/S00401-013-1123-8 |
0.51 |
|
| 2013 |
Golde TE, Borchelt DR, Giasson BI, Lewis J. Thinking laterally about neurodegenerative proteinopathies. The Journal of Clinical Investigation. 123: 1847-55. PMID 23635781 DOI: 10.1172/Jci66029 |
0.417 |
|
| 2013 |
Nalls MA, Duran R, Lopez G, Kurzawa-Akanbi M, McKeith IG, Chinnery PF, Morris CM, Theuns J, Crosiers D, Cras P, Engelborghs S, De Deyn PP, Van Broeckhoven C, Mann DM, Snowden J, ... ... Giasson BI, et al. A multicenter study of glucocerebrosidase mutations in dementia with Lewy bodies. Jama Neurology. 70: 727-35. PMID 23588557 DOI: 10.1001/Jamaneurol.2013.1925 |
0.472 |
|
| 2013 |
Schultheis PJ, Fleming SM, Clippinger AK, Lewis J, Tsunemi T, Giasson B, Dickson DW, Mazzulli JR, Bardgett ME, Haik KL, Ekhator O, Chava AK, Howard J, Gannon M, Hoffman E, et al. Atp13a2-deficient mice exhibit neuronal ceroid lipofuscinosis, limited α-synuclein accumulation and age-dependent sensorimotor deficits. Human Molecular Genetics. 22: 2067-82. PMID 23393156 DOI: 10.1093/Hmg/Ddt057 |
0.447 |
|
| 2012 |
Sacino AN, Giasson BI. Does a prion-like mechanism play a major role in the apparent spread of α-synuclein pathology? Alzheimer's Research & Therapy. 4: 48. PMID 23245350 DOI: 10.1186/Alzrt151 |
0.803 |
|
| 2012 |
Covy JP, Waxman EA, Giasson BI. Characterization of cellular protective effects of ATP13A2/PARK9 expression and alterations resulting from pathogenic mutants. Journal of Neuroscience Research. 90: 2306-16. PMID 22847264 DOI: 10.1002/Jnr.23112 |
0.781 |
|
| 2012 |
Emmer KL, Covy JP, Giasson BI. Studies of protein aggregation in A53T α-synuclein transgenic, Tg2576 transgenic, and P246L presenilin-1 knock-in cross bred mice. Neuroscience Letters. 507: 137-42. PMID 22188655 DOI: 10.1016/J.Neulet.2011.12.005 |
0.823 |
|
| 2011 |
Emmer KL, Waxman EA, Covy JP, Giasson BI. E46K human alpha-synuclein transgenic mice develop Lewy-like and tau pathology associated with age-dependent, detrimental motor impairment. The Journal of Biological Chemistry. 286: 35104-18. PMID 21846727 DOI: 10.1074/Jbc.M111.247965 |
0.839 |
|
| 2011 |
Waxman EA, Giasson BI. Induction of intracellular tau aggregation is promoted by α-synuclein seeds and provides novel insights into the hyperphosphorylation of tau. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 7604-18. PMID 21613474 DOI: 10.1523/Jneurosci.0297-11.2011 |
0.523 |
|
| 2011 |
Covy JP, Giasson BI. α-Synuclein, leucine-rich repeat kinase-2, and manganese in the pathogenesis of Parkinson disease. Neurotoxicology. 32: 622-9. PMID 21238487 DOI: 10.1016/J.Neuro.2011.01.003 |
0.804 |
|
| 2011 |
Waxman EA, Giasson BI. Characterization of kinases involved in the phosphorylation of aggregated α-synuclein. Journal of Neuroscience Research. 89: 231-47. PMID 21162130 DOI: 10.1002/Jnr.22537 |
0.425 |
|
| 2010 |
Goker-Alpan O, Stubblefield BK, Giasson BI, Sidransky E. Glucocerebrosidase is present in α-synuclein inclusions in Lewy body disorders. Acta Neuropathologica. 120: 641-9. PMID 20838799 DOI: 10.1007/S00401-010-0741-7 |
0.42 |
|
| 2010 |
Ramsey CP, Giasson BI. L10p and P158DEL DJ-1 mutations cause protein instability, aggregation, and dimerization impairments. Journal of Neuroscience Research. 88: 3111-24. PMID 20806408 DOI: 10.1002/Jnr.22477 |
0.784 |
|
| 2010 |
Covy JP, Giasson BI. The G2019S pathogenic mutation disrupts sensitivity of leucine-rich repeat kinase 2 to manganese kinase inhibition. Journal of Neurochemistry. 115: 36-46. PMID 20626563 DOI: 10.1111/J.1471-4159.2010.06894.X |
0.771 |
|
| 2010 |
Tsika E, Moysidou M, Guo J, Cushman M, Gannon P, Sandaltzopoulos R, Giasson BI, Krainc D, Ischiropoulos H, Mazzulli JR. Distinct region-specific alpha-synuclein oligomers in A53T transgenic mice: implications for neurodegeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 3409-18. PMID 20203200 DOI: 10.1523/Jneurosci.4977-09.2010 |
0.526 |
|
| 2010 |
Waxman EA, Giasson BI. A novel, high-efficiency cellular model of fibrillar alpha-synuclein inclusions and the examination of mutations that inhibit amyloid formation. Journal of Neurochemistry. 113: 374-88. PMID 20132485 DOI: 10.1111/J.1471-4159.2010.06592.X |
0.465 |
|
| 2010 |
Kuo YM, Li Z, Jiao Y, Gaborit N, Pani AK, Orrison BM, Bruneau BG, Giasson BI, Smeyne RJ, Gershon MD, Nussbaum RL. Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated alpha-synuclein gene mutations precede central nervous system changes. Human Molecular Genetics. 19: 1633-50. PMID 20106867 DOI: 10.1093/Hmg/Ddq038 |
0.468 |
|
| 2010 |
Ramsey CP, Tsika E, Ischiropoulos H, Giasson BI. DJ-1 deficient mice demonstrate similar vulnerability to pathogenic Ala53Thr human alpha-syn toxicity. Human Molecular Genetics. 19: 1425-37. PMID 20089532 DOI: 10.1093/Hmg/Ddq017 |
0.828 |
|
| 2010 |
Ramsey CP, Giasson BI. Identification and characterization of a novel endogenous murine parkin mutation. Journal of Neurochemistry. 113: 402-17. PMID 20089136 DOI: 10.1111/J.1471-4159.2010.06605.X |
0.802 |
|
| 2010 |
Waxman EA, Emmer KL, Giasson BI. Residue Glu83 plays a major role in negatively regulating alpha-synuclein amyloid formation. Biochemical and Biophysical Research Communications. 391: 1415-20. PMID 20026050 DOI: 10.1016/J.Bbrc.2009.12.079 |
0.478 |
|
| 2009 |
Waxman EA, Mazzulli JR, Giasson BI. Characterization of hydrophobic residue requirements for alpha-synuclein fibrillization. Biochemistry. 48: 9427-36. PMID 19722699 DOI: 10.1021/Bi900539P |
0.484 |
|
| 2009 |
Waxman EA, Covy JP, Bukh I, Li X, Dawson TM, Giasson BI. Leucine-rich repeat kinase 2 expression leads to aggresome formation that is not associated with alpha-synuclein inclusions. Journal of Neuropathology and Experimental Neurology. 68: 785-96. PMID 19535993 DOI: 10.1097/Nen.0B013E3181Aaf4Fd |
0.834 |
|
| 2009 |
Covy JP, Giasson BI. Identification of compounds that inhibit the kinase activity of leucine-rich repeat kinase 2. Biochemical and Biophysical Research Communications. 378: 473-7. PMID 19027715 DOI: 10.1016/J.Bbrc.2008.11.048 |
0.782 |
|
| 2009 |
Covy JP, Yuan W, Waxman EA, Hurtig HI, Van Deerlin VM, Giasson BI. Clinical and pathological characteristics of patients with leucine-rich repeat kinase-2 mutations. Movement Disorders : Official Journal of the Movement Disorder Society. 24: 32-9. PMID 19006185 DOI: 10.1002/Mds.22096 |
0.791 |
|
| 2009 |
Waxman EA, Giasson BI. Molecular mechanisms of alpha-synuclein neurodegeneration. Biochimica Et Biophysica Acta. 1792: 616-24. PMID 18955133 DOI: 10.1016/J.Bbadis.2008.09.013 |
0.486 |
|
| 2009 |
Covy JP, Giasson BI. Corrigendum to "Identification of compounds that inhibit the kinase activity of leucine-rich repeat kinase 2" [Biochem. Biophys. Res. Commun. 378 (2009) 473-477] (DOI:10.1016/j.bbrc.2008.11.048) Biochemical and Biophysical Research Communications. 387: 419-420. DOI: 10.1016/J.Bbrc.2009.06.066 |
0.751 |
|
| 2008 |
Ramsey CP, Giasson BI. The E163K DJ-1 mutant shows specific antioxidant deficiency. Brain Research. 1239: 1-11. PMID 18822273 DOI: 10.1016/J.Brainres.2008.09.009 |
0.808 |
|
| 2008 |
Waxman EA, Giasson BI. Specificity and regulation of casein kinase-mediated phosphorylation of alpha-synuclein. Journal of Neuropathology and Experimental Neurology. 67: 402-16. PMID 18451726 DOI: 10.1097/Nen.0B013E3186Fc995 |
0.45 |
|
| 2008 |
Waxman EA, Duda JE, Giasson BI. Characterization of antibodies that selectively detect alpha-synuclein in pathological inclusions. Acta Neuropathologica. 116: 37-46. PMID 18414880 DOI: 10.1007/S00401-008-0375-1 |
0.457 |
|
| 2008 |
Giasson BI, Van Deerlin VM. Mutations in LRRK2 as a cause of Parkinson's disease. Neuro-Signals. 16: 99-105. PMID 18097165 DOI: 10.1159/000109764 |
0.422 |
|
| 2008 |
Song WL, Lawson JA, Reilly D, Rokach J, Chang CT, Giasson B, FitzGerald GA. Neurofurans, novel indices of oxidant stress derived from docosahexaenoic acid. The Journal of Biological Chemistry. 283: 6-16. PMID 17921521 DOI: 10.1074/Jbc.M706124200 |
0.346 |
|
| 2008 |
Klegeris A, Pelech S, Giasson BI, Maguire J, Zhang H, McGeer EG, McGeer PL. Alpha-synuclein activates stress signaling protein kinases in THP-1 cells and microglia. Neurobiology of Aging. 29: 739-52. PMID 17166628 DOI: 10.1016/J.Neurobiolaging.2006.11.013 |
0.425 |
|
| 2007 |
Ramsey CP, Giasson BI. Role of mitochondrial dysfunction in Parkinson's disease: Implications for treatment. Drugs & Aging. 24: 95-105. PMID 17313198 DOI: 10.2165/00002512-200724020-00002 |
0.794 |
|
| 2007 |
Norris EH, Uryu K, Leight S, Giasson BI, Trojanowski JQ, Lee VM. Pesticide exposure exacerbates alpha-synucleinopathy in an A53T transgenic mouse model. The American Journal of Pathology. 170: 658-66. PMID 17255333 DOI: 10.2353/Ajpath.2007.060359 |
0.778 |
|
| 2006 |
Beal MF, Bossy-Wetzel E, Finkbeiner S, Fiskum G, Giasson B, Johnson C, Khachaturian ZS, Lee VM, Nicholls D, Reddy H, Reynolds I, Teplow DB, Thal LJ, Trojanowski JQ, Walsh DM, et al. Common threads in neurodegenerative disorders of aging. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 2: 322-6. PMID 19595906 DOI: 10.1016/J.Jalz.2006.08.008 |
0.622 |
|
| 2006 |
Klegeris A, Giasson BI, Zhang H, Maguire J, Pelech S, McGeer PL. Alpha-synuclein and its disease-causing mutants induce ICAM-1 and IL-6 in human astrocytes and astrocytoma cells. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 2000-8. PMID 17012252 DOI: 10.1096/Fj.06-6183Com |
0.424 |
|
| 2006 |
Mazzulli JR, Mishizen AJ, Giasson BI, Lynch DR, Thomas SA, Nakashima A, Nagatsu T, Ota A, Ischiropoulos H. Cytosolic catechols inhibit alpha-synuclein aggregation and facilitate the formation of intracellular soluble oligomeric intermediates. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 10068-78. PMID 17005870 DOI: 10.1523/Jneurosci.0896-06.2006 |
0.457 |
|
| 2006 |
Goker-Alpan O, Giasson BI, Eblan MJ, Nguyen J, Hurtig HI, Lee VM, Trojanowski JQ, Sidransky E. Glucocerebrosidase mutations are an important risk factor for Lewy body disorders. Neurology. 67: 908-10. PMID 16790605 DOI: 10.1212/01.Wnl.0000230215.41296.18 |
0.634 |
|
| 2006 |
Uryu K, Richter-Landsberg C, Welch W, Sun E, Goldbaum O, Norris EH, Pham CT, Yazawa I, Hilburger K, Micsenyi M, Giasson BI, Bonini NM, Lee VM, Trojanowski JQ. Convergence of heat shock protein 90 with ubiquitin in filamentous alpha-synuclein inclusions of alpha-synucleinopathies. The American Journal of Pathology. 168: 947-61. PMID 16507910 DOI: 10.2353/Ajpath.2006.050770 |
0.766 |
|
| 2006 |
Giasson BI, Covy JP, Bonini NM, Hurtig HI, Farrer MJ, Trojanowski JQ, Van Deerlin VM. Biochemical and pathological characterization of Lrrk2. Annals of Neurology. 59: 315-22. PMID 16437584 DOI: 10.1002/Ana.20791 |
0.824 |
|
| 2006 |
Duda JE, Giasson BI, Lee VM, Trojanowski JQ. Is the Initial Insult in Parkinson's Disease and Dementia with Lewy Bodies a Neuritic Dystrophy? Annals of the New York Academy of Sciences. 991: 295-297. DOI: 10.1111/J.1749-6632.2003.Tb07488.X |
0.61 |
|
| 2006 |
Covy JP, Van Deerlin VM, Giasson BI. Lack of evidence for Lrrk2 in α-synuclein pathological inclusions [4] Annals of Neurology. 60: 618-619. DOI: 10.1002/Ana.21029 |
0.798 |
|
| 2005 |
Bonini NM, Giasson BI. Snaring the function of alpha-synuclein. Cell. 123: 359-61. PMID 16269324 DOI: 10.1016/J.Cell.2005.10.017 |
0.398 |
|
| 2005 |
Meulener MC, Graves CL, Sampathu DM, Armstrong-Gold CE, Bonini NM, Giasson BI. DJ-1 is present in a large molecular complex in human brain tissue and interacts with alpha-synuclein. Journal of Neurochemistry. 93: 1524-32. PMID 15935068 DOI: 10.1111/J.1471-4159.2005.03145.X |
0.833 |
|
| 2005 |
Mishizen-Eberz AJ, Norris EH, Giasson BI, Hodara R, Ischiropoulos H, Lee VM, Trojanowski JQ, Lynch DR. Cleavage of alpha-synuclein by calpain: potential role in degradation of fibrillized and nitrated species of alpha-synuclein. Biochemistry. 44: 7818-29. PMID 15909996 DOI: 10.1021/Bi047846Q |
0.762 |
|
| 2005 |
Norris EH, Giasson BI. Role of oxidative damage in protein aggregation associated with Parkinson's disease and related disorders. Antioxidants & Redox Signaling. 7: 672-84. PMID 15890012 DOI: 10.1089/Ars.2005.7.672 |
0.753 |
|
| 2005 |
Liu CW, Giasson BI, Lewis KA, Lee VM, Demartino GN, Thomas PJ. A precipitating role for truncated alpha-synuclein and the proteasome in alpha-synuclein aggregation: implications for pathogenesis of Parkinson disease. The Journal of Biological Chemistry. 280: 22670-8. PMID 15840579 DOI: 10.1074/Jbc.M501508200 |
0.645 |
|
| 2005 |
Norris EH, Giasson BI, Hodara R, Xu S, Trojanowski JQ, Ischiropoulos H, Lee VM. Reversible inhibition of alpha-synuclein fibrillization by dopaminochrome-mediated conformational alterations. The Journal of Biological Chemistry. 280: 21212-9. PMID 15817478 DOI: 10.1074/Jbc.M412621200 |
0.752 |
|
| 2005 |
Yazawa I, Giasson BI, Sasaki R, Zhang B, Joyce S, Uryu K, Trojanowski JQ, Lee VM. Mouse model of multiple system atrophy alpha-synuclein expression in oligodendrocytes causes glial and neuronal degeneration. Neuron. 45: 847-59. PMID 15797547 DOI: 10.1016/J.Neuron.2005.01.032 |
0.624 |
|
| 2005 |
Greenbaum EA, Graves CL, Mishizen-Eberz AJ, Lupoli MA, Lynch DR, Englander SW, Axelsen PH, Giasson BI. The E46K mutation in alpha-synuclein increases amyloid fibril formation. The Journal of Biological Chemistry. 280: 7800-7. PMID 15632170 DOI: 10.1074/Jbc.M411638200 |
0.45 |
|
| 2004 |
Giasson BI. Mitochondrial injury: a hot spot for parkinsonism and Parkinson's disease? Science of Aging Knowledge Environment : Sage Ke. 2004: pe42. PMID 15576821 DOI: 10.1126/Sageke.2004.48.Pe42 |
0.405 |
|
| 2004 |
Hodara R, Norris EH, Giasson BI, Mishizen-Eberz AJ, Lynch DR, Lee VM, Ischiropoulos H. Functional consequences of alpha-synuclein tyrosine nitration: diminished binding to lipid vesicles and increased fibril formation. The Journal of Biological Chemistry. 279: 47746-53. PMID 15364911 DOI: 10.1074/Jbc.M408906200 |
0.731 |
|
| 2004 |
Kotzbauer PT, Giasson BI, Kravitz AV, Golbe LI, Mark MH, Trojanowski JQ, Lee VM. Fibrillization of alpha-synuclein and tau in familial Parkinson's disease caused by the A53T alpha-synuclein mutation. Experimental Neurology. 187: 279-88. PMID 15144854 DOI: 10.1016/J.Expneurol.2004.01.007 |
0.657 |
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| 2004 |
Wilson CA, Murphy DD, Giasson BI, Zhang B, Trojanowski JQ, Lee VM. Degradative organelles containing mislocalized alpha-and beta-synuclein proliferate in presenilin-1 null neurons. The Journal of Cell Biology. 165: 335-46. PMID 15123735 DOI: 10.1083/Jcb.200403061 |
0.733 |
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| 2004 |
Norris EH, Giasson BI, Lee VM. Alpha-synuclein: normal function and role in neurodegenerative diseases. Current Topics in Developmental Biology. 60: 17-54. PMID 15094295 DOI: 10.1016/S0070-2153(04)60002-0 |
0.774 |
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| 2004 |
Lee VM, Giasson BI, Trojanowski JQ. More than just two peas in a pod: common amyloidogenic properties of tau and alpha-synuclein in neurodegenerative diseases. Trends in Neurosciences. 27: 129-34. PMID 15036877 DOI: 10.1016/J.Tins.2004.01.007 |
0.692 |
|
| 2004 |
Norris EH, Giasson BI, Xu S, Hodara R, Trojanowski JQ, Ischiropoulos H, Lee V. P1-302 Implications of dopamine-induced modificationsof alpha-synuclein protein in the pathogenesis of Parkinson's disease Neurobiology of Aging. 25: S182. DOI: 10.1016/S0197-4580(04)80615-8 |
0.763 |
|
| 2004 |
Giasson BI, Lee VMY, Trojanowski JQ. Animal models of neurodegenerative dementing disorders other than Alzheimer's disease Clinical Neuroscience Research. 3: 427-436. DOI: 10.1016/J.Cnr.2004.04.008 |
0.55 |
|
| 2003 |
Uryu K, Giasson BI, Longhi L, Martinez D, Murray I, Conte V, Nakamura M, Saatman K, Talbot K, Horiguchi T, McIntosh T, Lee VM, Trojanowski JQ. Age-dependent synuclein pathology following traumatic brain injury in mice. Experimental Neurology. 184: 214-24. PMID 14637093 DOI: 10.1016/S0014-4886(03)00245-0 |
0.776 |
|
| 2003 |
Giasson BI, Lee VM, Trojanowski JQ. Interactions of amyloidogenic proteins. Neuromolecular Medicine. 4: 49-58. PMID 14528052 DOI: 10.1385/Nmm:4:1-2:49 |
0.688 |
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| 2003 |
Pawlyk AC, Giasson BI, Sampathu DM, Perez FA, Lim KL, Dawson VL, Dawson TM, Palmiter RD, Trojanowski JQ, Lee VM. Novel monoclonal antibodies demonstrate biochemical variation of brain parkin with age. The Journal of Biological Chemistry. 278: 48120-8. PMID 12972409 DOI: 10.1074/Jbc.M306889200 |
0.81 |
|
| 2003 |
Crystal AS, Giasson BI, Crowe A, Kung MP, Zhuang ZP, Trojanowski JQ, Lee VM. A comparison of amyloid fibrillogenesis using the novel fluorescent compound K114. Journal of Neurochemistry. 86: 1359-68. PMID 12950445 DOI: 10.1046/J.1471-4159.2003.01949.X |
0.812 |
|
| 2003 |
Horiguchi T, Uryu K, Giasson BI, Ischiropoulos H, LightFoot R, Bellmann C, Richter-Landsberg C, Lee VM, Trojanowski JQ. Nitration of tau protein is linked to neurodegeneration in tauopathies. The American Journal of Pathology. 163: 1021-31. PMID 12937143 DOI: 10.1016/S0002-9440(10)63462-1 |
0.632 |
|
| 2003 |
Mishizen-Eberz AJ, Guttmann RP, Giasson BI, Day GA, Hodara R, Ischiropoulos H, Lee VM, Trojanowski JQ, Lynch DR. Distinct cleavage patterns of normal and pathologic forms of alpha-synuclein by calpain I in vitro. Journal of Neurochemistry. 86: 836-47. PMID 12887682 DOI: 10.1046/J.1471-4159.2003.01878.X |
0.63 |
|
| 2003 |
Giasson BI, Lee VM. Are ubiquitination pathways central to Parkinson's disease? Cell. 114: 1-8. PMID 12859888 DOI: 10.1016/S0092-8674(03)00509-9 |
0.545 |
|
| 2003 |
Murray IV, Giasson BI, Quinn SM, Koppaka V, Axelsen PH, Ischiropoulos H, Trojanowski JQ, Lee VM. Role of alpha-synuclein carboxy-terminus on fibril formation in vitro. Biochemistry. 42: 8530-40. PMID 12859200 DOI: 10.1021/Bi027363R |
0.764 |
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| 2003 |
Norris EH, Giasson BI, Ischiropoulos H, Lee VM. Effects of oxidative and nitrative challenges on alpha-synuclein fibrillogenesis involve distinct mechanisms of protein modifications. The Journal of Biological Chemistry. 278: 27230-40. PMID 12857790 DOI: 10.1074/Jbc.M212436200 |
0.743 |
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| 2003 |
Sampathu DM, Giasson BI, Pawlyk AC, Trojanowski JQ, Lee VM. Ubiquitination of alpha-synuclein is not required for formation of pathological inclusions in alpha-synucleinopathies. The American Journal of Pathology. 163: 91-100. PMID 12819014 DOI: 10.1016/S0002-9440(10)63633-4 |
0.821 |
|
| 2003 |
Giasson BI, Mabon ME, Duda JE, Montine TJ, Robertson D, Hurtig HI, Lee VM, Trojanowski JQ. Tau and 14-3-3 in glial cytoplasmic inclusions of multiple system atrophy. Acta Neuropathologica. 106: 243-50. PMID 12811584 DOI: 10.1007/S00401-003-0726-X |
0.66 |
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| 2003 |
Fung KM, Rorke LB, Giasson B, Lee VM, Trojanowski JQ. Expression of alpha-, beta-, and gamma-synuclein in glial tumors and medulloblastomas. Acta Neuropathologica. 106: 167-75. PMID 12783249 DOI: 10.1007/S00401-003-0718-X |
0.693 |
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| 2003 |
Giasson BI, Forman MS, Higuchi M, Golbe LI, Graves CL, Kotzbauer PT, Trojanowski JQ, Lee VM. Initiation and synergistic fibrillization of tau and alpha-synuclein. Science (New York, N.Y.). 300: 636-40. PMID 12714745 DOI: 10.1126/Science.1082324 |
0.771 |
|
| 2003 |
Duda JE, Giasson BI, Lee VMY, Trojanowski JQ. Is the initial insult in Parkinson's disease and dementia with Lewy bodies a neuritic dystrophy? Annals of the New York Academy of Sciences. 991: 295-297. |
0.434 |
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| 2002 |
Giasson BI, Sampathu DM, Wilson CA, Vogelsberg-Ragaglia V, Mushynski WE, Lee VM. The environmental toxin arsenite induces tau hyperphosphorylation. Biochemistry. 41: 15376-87. PMID 12484777 DOI: 10.1021/Bi026813C |
0.814 |
|
| 2002 |
Neumann M, Kahle PJ, Giasson BI, Ozmen L, Borroni E, Spooren W, Müller V, Odoy S, Fujiwara H, Hasegawa M, Iwatsubo T, Trojanowski JQ, Kretzschmar HA, Haass C. Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies. The Journal of Clinical Investigation. 110: 1429-39. PMID 12438441 DOI: 10.1172/Jci15777 |
0.524 |
|
| 2002 |
Duda JE, Giasson BI, Mabon ME, Lee VM, Trojanowski JQ. Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases. Annals of Neurology. 52: 205-10. PMID 12210791 DOI: 10.1002/Ana.10279 |
0.64 |
|
| 2002 |
Liu HN, Giasson BI, Mushynski WE, Almazan G. AMPA receptor-mediated toxicity in oligodendrocyte progenitors involves free radical generation and activation of JNK, calpain and caspase 3. Journal of Neurochemistry. 82: 398-409. PMID 12124441 DOI: 10.1046/J.1471-4159.2002.00981.X |
0.636 |
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| 2002 |
Pan ZZ, Bruening W, Giasson BI, Lee VM, Godwin AK. Gamma-synuclein promotes cancer cell survival and inhibits stress- and chemotherapy drug-induced apoptosis by modulating MAPK pathways. The Journal of Biological Chemistry. 277: 35050-60. PMID 12121974 DOI: 10.1074/Jbc.M201650200 |
0.475 |
|
| 2002 |
Duda JE, Giasson BI, Mabon ME, Miller DC, Golbe LI, Lee VM, Trojanowski JQ. Concurrence of alpha-synuclein and tau brain pathology in the Contursi kindred. Acta Neuropathologica. 104: 7-11. PMID 12070658 DOI: 10.1007/S00401-002-0563-3 |
0.672 |
|
| 2002 |
Giasson BI, Duda JE, Quinn SM, Zhang B, Trojanowski JQ, Lee VM. Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein. Neuron. 34: 521-33. PMID 12062037 DOI: 10.1016/S0896-6273(02)00682-7 |
0.635 |
|
| 2002 |
Giasson BI, Ischiropoulos H, Lee VM, Trojanowski JQ. The relationship between oxidative/nitrative stress and pathological inclusions in Alzheimer's and Parkinson's diseases. Free Radical Biology & Medicine. 32: 1264-75. PMID 12057764 DOI: 10.1016/S0891-5849(02)00804-3 |
0.617 |
|
| 2001 |
Giasson BI, Duda JE, Forman MS, Lee VM, Trojanowski JQ. Prominent perikaryal expression of alpha- and beta-synuclein in neurons of dorsal root ganglion and in medullary neurons. Experimental Neurology. 172: 354-62. PMID 11716559 DOI: 10.1006/Exnr.2001.7805 |
0.741 |
|
| 2001 |
Paxinou E, Chen Q, Weisse M, Giasson BI, Norris EH, Rueter SM, Trojanowski JQ, Lee VM, Ischiropoulos H. Induction of alpha-synuclein aggregation by intracellular nitrative insult. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 8053-61. PMID 11588178 |
0.746 |
|
| 2001 |
Giasson BI, Lee VM. Parkin and the molecular pathways of Parkinson's disease. Neuron. 31: 885-8. PMID 11580890 DOI: 10.1016/S0896-6273(01)00439-1 |
0.398 |
|
| 2001 |
Schmidt ML, Schuck T, Sheridan S, Kung MP, Kung H, Zhuang ZP, Bergeron C, Lamarche JS, Skovronsky D, Giasson BI, Lee VM, Trojanowski JQ. The fluorescent Congo red derivative, (trans, trans)-1-bromo-2,5-bis-(3-hydroxycarbonyl-4-hydroxy)styrylbenzene (BSB), labels diverse beta-pleated sheet structures in postmortem human neurodegenerative disease brains. The American Journal of Pathology. 159: 937-43. PMID 11549586 DOI: 10.1016/S0002-9440(10)61769-5 |
0.788 |
|
| 2001 |
Przedborski S, Chen Q, Vila M, Giasson BI, Djaldatti R, Vukosavic S, Souza JM, Jackson-Lewis V, Lee VM, Ischiropoulos H. Oxidative post-translational modifications of alpha-synuclein in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease. Journal of Neurochemistry. 76: 637-40. PMID 11208927 DOI: 10.1046/J.1471-4159.2001.00174.X |
0.442 |
|
| 2001 |
Giasson BI, Murray IV, Trojanowski JQ, Lee VM. A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly. The Journal of Biological Chemistry. 276: 2380-6. PMID 11060312 DOI: 10.1074/Jbc.M008919200 |
0.765 |
|
| 2001 |
Paxinou E, Chen Q, Weisse M, Giasson BI, Norris EH, Rueter SM, Trojanowski JQ, Lee VM, Ischiropoulos H. Induction of α-Synuclein Aggregation by Intracellular Nitrative Insult The Journal of Neuroscience. 21: 8053-8061. DOI: 10.1523/Jneurosci.21-20-08053.2001 |
0.72 |
|
| 2000 |
Giasson BI, Lee VM. A new link between pesticides and Parkinson's disease. Nature Neuroscience. 3: 1227-8. PMID 11100135 DOI: 10.1038/81737 |
0.357 |
|
| 2000 |
Duda JE, Giasson BI, Chen Q, Gur TL, Hurtig HI, Stern MB, Gollomp SM, Ischiropoulos H, Lee VM, Trojanowski JQ. Widespread nitration of pathological inclusions in neurodegenerative synucleinopathies. The American Journal of Pathology. 157: 1439-45. PMID 11073803 DOI: 10.1016/S0002-9440(10)64781-5 |
0.583 |
|
| 2000 |
Giasson BI, Duda JE, Murray IV, Chen Q, Souza JM, Hurtig HI, Ischiropoulos H, Trojanowski JQ, Lee VM. Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions. Science (New York, N.Y.). 290: 985-9. PMID 11062131 DOI: 10.1126/Science.290.5493.985 |
0.788 |
|
| 2000 |
Duda JE, Giasson BI, Gur TL, Montine TJ, Robertson D, Biaggioni I, Hurtig HI, Stern MB, Gollomp SM, Grossman M, Lee VM, Trojanowski JQ. Immunohistochemical and biochemical studies demonstrate a distinct profile of alpha-synuclein permutations in multiple system atrophy. Journal of Neuropathology and Experimental Neurology. 59: 830-41. PMID 11005264 DOI: 10.1093/Jnen/59.9.830 |
0.508 |
|
| 2000 |
Galvin JE, Giasson B, Hurtig HI, Lee VM, Trojanowski JQ. Neurodegeneration with brain iron accumulation, type 1 is characterized by alpha-, beta-, and gamma-synuclein neuropathology. The American Journal of Pathology. 157: 361-8. PMID 10934140 DOI: 10.1016/S0002-9440(10)64548-8 |
0.519 |
|
| 2000 |
Souza JM, Giasson BI, Lee VM, Ischiropoulos H. Chaperone-like activity of synucleins. Febs Letters. 474: 116-9. PMID 10828462 DOI: 10.1016/S0014-5793(00)01563-5 |
0.44 |
|
| 2000 |
Bruening W, Giasson BI, Klein-Szanto AJ, Lee VM, Trojanowski JQ, Godwin AK. Synucleins are expressed in the majority of breast and ovarian carcinomas and in preneoplastic lesions of the ovary. Cancer. 88: 2154-63. PMID 10813729 DOI: 10.1002/(Sici)1097-0142(20000501)88:9<2154::Aid-Cncr23>3.0.Co;2-9 |
0.436 |
|
| 2000 |
Souza JM, Giasson BI, Chen Q, Lee VM, Ischiropoulos H. Dityrosine cross-linking promotes formation of stable alpha -synuclein polymers. Implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies. The Journal of Biological Chemistry. 275: 18344-9. PMID 10747881 DOI: 10.1074/Jbc.M000206200 |
0.453 |
|
| 2000 |
Giasson BI, Jakes R, Goedert M, Duda JE, Leight S, Trojanowski JQ, Lee VM. A panel of epitope-specific antibodies detects protein domains distributed throughout human alpha-synuclein in Lewy bodies of Parkinson's disease. Journal of Neuroscience Research. 59: 528-33. PMID 10679792 DOI: 10.1002/(Sici)1097-4547(20000215)59:4<528::Aid-Jnr8>3.0.Co;2-0 |
0.655 |
|
| 2000 |
Ischiropoulos H, Souza JM, Giasson BI, Chen Q, Duda JE, Trojanowski JQ, Lee VM. Mechanisms of oxidative damage in neurodegenerative synucleinopathies Neurobiology of Aging. 21: 283. DOI: 10.1016/S0197-4580(00)83223-6 |
0.39 |
|
| 2000 |
Duda JE, Giasson BI, Chen Q, Souza JM, Murray IV, Ischiropoulos H, Lee VM, Trojanowski JQ. α-Synuclein nitration in neuropathological inclusions Neurobiology of Aging. 21: 53. DOI: 10.1016/S0197-4580(00)82915-2 |
0.708 |
|
| 2000 |
Galvin JE, Giasson BI, Gambetti PL, My Lee V, Trojanowski JQ. The neuropathology of neurodegeneration with brain iron accumulation, type 1 (NBIA 1) contains insoluble α-synuclean Neurobiology of Aging. 21: 65. DOI: 10.1016/S0197-4580(00)82514-2 |
0.43 |
|
| 1999 |
Giasson BI, Uryu K, Trojanowski JQ, Lee VM. Mutant and wild type human alpha-synucleins assemble into elongated filaments with distinct morphologies in vitro. The Journal of Biological Chemistry. 274: 7619-22. PMID 10075647 DOI: 10.1074/Jbc.274.12.7619 |
0.56 |
|
| 1999 |
Giasson BI, Bruening W, Durham HD, Mushynski WE. Activation of stress-activated protein kinases correlates with neurite outgrowth induced by protease inhibition in PC12 cells. Journal of Neurochemistry. 72: 1081-7. PMID 10037479 DOI: 10.1046/J.1471-4159.1999.0721081.X |
0.651 |
|
| 1999 |
Bruening W, Roy J, Giasson B, Figlewicz DA, Mushynski WE, Durham HD. Up-regulation of protein chaperones preserves viability of cells expressing toxic Cu/Zn-superoxide dismutase mutants associated with amyotrophic lateral sclerosis. Journal of Neurochemistry. 72: 693-9. PMID 9930742 DOI: 10.1046/J.1471-4159.1999.0720693.X |
0.684 |
|
| 1998 |
Lippa CF, Fujiwara H, Mann DM, Giasson B, Baba M, Schmidt ML, Nee LE, O'Connell B, Pollen DA, St George-Hyslop P, Ghetti B, Nochlin D, Bird TD, Cairns NJ, Lee VM, et al. Lewy bodies contain altered alpha-synuclein in brains of many familial Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes. The American Journal of Pathology. 153: 1365-70. PMID 9811326 DOI: 10.1016/S0002-9440(10)65722-7 |
0.575 |
|
| 1998 |
Tu PH, Galvin JE, Baba M, Giasson B, Tomita T, Leight S, Nakajo S, Iwatsubo T, Trojanowski JQ, Lee VM. Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble alpha-synuclein. Annals of Neurology. 44: 415-22. PMID 9749615 DOI: 10.1002/Ana.410440324 |
0.553 |
|
| 1998 |
Giasson BI, Mushynski WE. Intermediate filament disassembly in cultured dorsal root ganglion neurons is associated with amino-terminal head domain phosphorylation of specific subunits. Journal of Neurochemistry. 70: 1869-75. PMID 9572270 DOI: 10.1046/J.1471-4159.1998.70051869.X |
0.685 |
|
| 1998 |
Bruening W, Giasson B, Mushynski W, Durham HD. Activation of stress-activated MAP protein kinases up-regulates expression of transgenes driven by the cytomegalovirus immediate/early promoter Nucleic Acids Research. 26: 486-489. PMID 9421504 DOI: 10.1093/Nar/26.2.486 |
0.627 |
|
| 1997 |
Giasson BI, Mushynski WE. Study of proline-directed protein kinases involved in phosphorylation of the heavy neurofilament subunit. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 9466-72. PMID 9391002 DOI: 10.1523/Jneurosci.17-24-09466.1997 |
0.68 |
|
| 1997 |
Giasson BI, Mushynski WE. Developmentally regulated stabilization of neuronal intermediate filaments in rat cerebral cortex. Neuroscience Letters. 229: 77-80. PMID 9223595 DOI: 10.1016/S0304-3940(97)00425-4 |
0.669 |
|
| 1997 |
Giasson BI, Mushynski WE. Okadaic acid reversibly inhibits neurite outgrowth in embryonic dorsal root ganglion neurons. Journal of Neurobiology. 32: 193-201. PMID 9032661 DOI: 10.1002/(Sici)1097-4695(199702)32:2<193::Aid-Neu4>3.0.Co;2-3 |
0.654 |
|
| 1996 |
Giasson BI, Mushynski WE. Aberrant stress-induced phosphorylation of perikaryal neurofilaments. The Journal of Biological Chemistry. 271: 30404-9. PMID 8940004 DOI: 10.1074/Jbc.271.48.30404 |
0.684 |
|
| 1996 |
Giasson BI, Cromlish JA, Athlan ES, Mushynski WE. Activation of cyclic AMP-dependent protein kinase in okadaic acid-treated neurons potentiates neurofilament fragmentation and stimulates phosphorylation of Ser2 in the low-molecular-mass neurofilament subunit. Journal of Neurochemistry. 66: 1207-13. PMID 8769885 DOI: 10.1046/J.1471-4159.1996.66031207.X |
0.652 |
|
| 1995 |
Jayaraman D, Giasson BI, Mushynski WE. Increased phosphorylation of neurofilament subunits in PC12 cells and rat dorsal root ganglion neurons treated with N-Acetyl-Leu-Leu-norleucinal. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. 13: 753-8. PMID 8787865 DOI: 10.1016/0736-5748(95)00060-7 |
0.659 |
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