Benoit I. Giasson, Ph.D. - Publications

Affiliations: 
Pharmacology University of Pennsylvania, Philadelphia, PA, United States 
 Neuroscience University of Florida, Gainesville, Gainesville, FL, United States 
Area:
Neurodegeneration ,Parkinson’s disease, Neuronal Damage, Protein Aggregation,Kinases, Alpha-synuclein, Tau
Website:
http://ctrnd.med.ufl.edu/faculty/dr-benoit-giasson/

125 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Sorrentino ZA, Goodwin MS, Riffe CJ, Dhillon JS, Xia Y, Gorion KM, Vijayaraghavan N, McFarland KN, Golbe LI, Yachnis AT, Giasson BI. Unique α-synuclein pathology within the amygdala in Lewy body dementia: implications for disease initiation and progression. Acta Neuropathologica Communications. 7: 142. PMID 31477175 DOI: 10.1186/s40478-019-0787-2  0.32
2017 Tayebi N, Parisiadou L, Berhe B, Gonzalez AN, Serra-Vinardell J, Tamargo RJ, Maniwang E, Sorrentino Z, Fujiwara H, Grey RJ, Hassan S, Blech-Hermoni YN, Chen C, McGlinchey R, Makariou-Pikis C, ... ... Giasson BI, et al. Glucocerebrosidase haploinsufficiency in A53T α-synuclein mice impacts disease onset and course. Molecular Genetics and Metabolism. 122: 198-208. PMID 29173981 DOI: 10.1016/j.ymgme.2017.11.001  0.32
2016 Sacino AN, Brooks MM, Chakrabarty P, Saha K, Khoshbouei H, Golde TE, Giasson BI. Proteolysis of α-Synuclein Fibrils in the Lysosomal Pathway Limits Induction of Inclusion Pathology. Journal of Neurochemistry. PMID 27424880 DOI: 10.1111/jnc.13743  1
2015 Uchihara T, Giasson BI, Paulus W. Propagation of Aβ, tau and α-synuclein pathology between experimental models and human reality: prions, propagons and propaganda. Acta Neuropathologica. PMID 26715564 DOI: 10.1007/s00401-015-1517-x  1
2015 Sacino AN, Ayers JI, Brooks MM, Chakrabarty P, Hudson VJ, Howard JK, Golde TE, Giasson BI, Borchelt DR. Non-prion-type transmission in A53T α-synuclein transgenic mice: a normal component of spinal homogenates from naïve non-transgenic mice induces robust α-synuclein pathology. Acta Neuropathologica. PMID 26541429 DOI: 10.1007/s00401-015-1505-1  1
2015 Uchihara T, Giasson BI. Propagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies. Acta Neuropathologica. PMID 26446103 DOI: 10.1007/s00401-015-1485-1  1
2015 Hamm M, Bailey R, Shaw G, Yen SH, Lewis J, Giasson BI. Physiologically relevant factors influence tau phosphorylation by leucine-rich repeat kinase 2. Journal of Neuroscience Research. PMID 26123245 DOI: 10.1002/jnr.23614  1
2015 Chakrabarty P, Hudson Iii VJ, Sacino AN, Brooks MM, D'Alton S, Lewis J, Golde TE, Giasson BI. Inefficient induction and spread of seeded tau pathology in P301L mouse model of tauopathy suggests inherent physiological barriers to transmission. Acta Neuropathologica. 130: 303-5. PMID 25982997 DOI: 10.1007/s00401-015-1444-x  1
2015 Rutherford NJ, Giasson BI. The A53E α-synuclein pathological mutation demonstrates reduced aggregation propensity in vitro and in cell culture. Neuroscience Letters. 597: 43-8. PMID 25892596 DOI: 10.1016/j.neulet.2015.04.022  1
2014 Fishbein I, Kuo YM, Giasson BI, Nussbaum RL. Augmentation of phenotype in a transgenic Parkinson mouse heterozygous for a Gaucher mutation. Brain : a Journal of Neurology. 137: 3235-47. PMID 25351739 DOI: 10.1093/brain/awu291  1
2014 Sacino AN, Brooks M, McKinney AB, Thomas MA, Shaw G, Golde TE, Giasson BI. Brain injection of α-synuclein induces multiple proteinopathies, gliosis, and a neuronal injury marker. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 12368-78. PMID 25209277 DOI: 10.1523/JNEUROSCI.2102-14.2014  0.52
2014 Sacino AN, Brooks M, Thomas MA, McKinney AB, Lee S, Regenhardt RW, McGarvey NH, Ayers JI, Notterpek L, Borchelt DR, Golde TE, Giasson BI. Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 111: 10732-7. PMID 25002524 DOI: 10.1073/pnas.1321785111  0.52
2014 Rutherford NJ, Moore BD, Golde TE, Giasson BI. Divergent effects of the H50Q and G51D SNCA mutations on the aggregation of α-synuclein. Journal of Neurochemistry. 131: 859-67. PMID 24984882 DOI: 10.1111/jnc.12806  1
2014 Guo L, Giasson BI, Glavis-Bloom A, Brewer MD, Shorter J, Gitler AD, Yang X. A cellular system that degrades misfolded proteins and protects against neurodegeneration. Molecular Cell. 55: 15-30. PMID 24882209 DOI: 10.1016/j.molcel.2014.04.030  0.52
2014 Sacino AN, Brooks M, Thomas MA, McKinney AB, McGarvey NH, Rutherford NJ, Ceballos-Diaz C, Robertson J, Golde TE, Giasson BI. Amyloidogenic α-synuclein seeds do not invariably induce rapid, widespread pathology in mice. Acta Neuropathologica. 127: 645-65. PMID 24659240 DOI: 10.1007/s00401-014-1268-0  0.52
2014 Escobar VD, Kuo YM, Orrison BM, Giasson BI, Nussbaum RL. Transgenic mice expressing S129 phosphorylation mutations in α-synuclein. Neuroscience Letters. 563: 96-100. PMID 24486885 DOI: 10.1016/j.neulet.2014.01.033  0.52
2014 Gould N, Mor DE, Lightfoot R, Malkus K, Giasson B, Ischiropoulos H. Evidence of native α-synuclein conformers in the human brain Journal of Biological Chemistry. 289: 7929-7934. PMID 24474688 DOI: 10.1074/jbc.C113.538249  1
2013 Musiek ES, Lim MM, Yang G, Bauer AQ, Qi L, Lee Y, Roh JH, Ortiz-Gonzalez X, Dearborn JT, Culver JP, Herzog ED, Hogenesch JB, Wozniak DF, Dikranian K, Giasson BI, et al. Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration. The Journal of Clinical Investigation. 123: 5389-400. PMID 24270424 DOI: 10.1172/JCI70317  0.52
2013 Sacino AN, Brooks M, McGarvey NH, McKinney AB, Thomas MA, Levites Y, Ran Y, Golde TE, Giasson BI. Induction of CNS α-synuclein pathology by fibrillar and non-amyloidogenic recombinant α-synuclein. Acta Neuropathologica Communications. 1: 38. PMID 24252149 DOI: 10.1186/2051-5960-1-38  0.52
2013 Bailey RM, Covy JP, Melrose HL, Rousseau L, Watkinson R, Knight J, Miles S, Farrer MJ, Dickson DW, Giasson BI, Lewis J. LRRK2 phosphorylates novel tau epitopes and promotes tauopathy. Acta Neuropathologica. 126: 809-27. PMID 24113872 DOI: 10.1007/s00401-013-1188-4  0.52
2013 Rutherford NJ, Lewis J, Clippinger AK, Thomas MA, Adamson J, Cruz PE, Cannon A, Xu G, Golde TE, Shaw G, Borchelt DR, Giasson BI. Unbiased screen reveals ubiquilin-1 and -2 highly associated with huntingtin inclusions. Brain Research. 1524: 62-73. PMID 23774650 DOI: 10.1016/j.brainres.2013.06.006  0.52
2013 Sacino AN, Thomas MA, Ceballos-Diaz C, Cruz PE, Rosario AM, Lewis J, Giasson BI, Golde TE. Conformational templating of α-synuclein aggregates in neuronal-glial cultures. Molecular Neurodegeneration. 8: 17. PMID 23714769 DOI: 10.1186/1750-1326-8-17  0.52
2013 Golde TE, Borchelt DR, Giasson BI, Lewis J. Thinking laterally about neurodegenerative proteinopathies. The Journal of Clinical Investigation. 123: 1847-55. PMID 23635781 DOI: 10.1172/JCI66029  0.52
2013 Nalls MA, Duran R, Lopez G, Kurzawa-Akanbi M, McKeith IG, Chinnery PF, Morris CM, Theuns J, Crosiers D, Cras P, Engelborghs S, De Deyn PP, Van Broeckhoven C, Mann DM, Snowden J, ... ... Giasson BI, et al. A multicenter study of glucocerebrosidase mutations in dementia with Lewy bodies. Jama Neurology. 70: 727-35. PMID 23588557 DOI: 10.1001/jamaneurol.2013.1925  1
2013 Schultheis PJ, Fleming SM, Clippinger AK, Lewis J, Tsunemi T, Giasson B, Dickson DW, Mazzulli JR, Bardgett ME, Haik KL, Ekhator O, Chava AK, Howard J, Gannon M, Hoffman E, et al. Atp13a2-deficient mice exhibit neuronal ceroid lipofuscinosis, limited α-synuclein accumulation and age-dependent sensorimotor deficits. Human Molecular Genetics. 22: 2067-82. PMID 23393156 DOI: 10.1093/hmg/ddt057  1
2012 Sacino AN, Giasson BI. Does a prion-like mechanism play a major role in the apparent spread of α-synuclein pathology? Alzheimer's Research & Therapy. 4: 48. PMID 23245350 DOI: 10.1186/alzrt151  0.52
2012 Covy JP, Waxman EA, Giasson BI. Characterization of cellular protective effects of ATP13A2/PARK9 expression and alterations resulting from pathogenic mutants. Journal of Neuroscience Research. 90: 2306-16. PMID 22847264 DOI: 10.1002/jnr.23112  0.52
2012 Emmer KL, Covy JP, Giasson BI. Studies of protein aggregation in A53T α-synuclein transgenic, Tg2576 transgenic, and P246L presenilin-1 knock-in cross bred mice. Neuroscience Letters. 507: 137-42. PMID 22188655 DOI: 10.1016/j.neulet.2011.12.005  1
2011 Emmer KL, Waxman EA, Covy JP, Giasson BI. E46K human alpha-synuclein transgenic mice develop Lewy-like and tau pathology associated with age-dependent, detrimental motor impairment. The Journal of Biological Chemistry. 286: 35104-18. PMID 21846727 DOI: 10.1074/jbc.M111.247965  1
2011 Waxman EA, Giasson BI. Induction of intracellular tau aggregation is promoted by α-synuclein seeds and provides novel insights into the hyperphosphorylation of tau. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 7604-18. PMID 21613474 DOI: 10.1523/JNEUROSCI.0297-11.2011  1
2011 Covy JP, Giasson BI. α-Synuclein, leucine-rich repeat kinase-2, and manganese in the pathogenesis of Parkinson disease. Neurotoxicology. 32: 622-9. PMID 21238487 DOI: 10.1016/j.neuro.2011.01.003  1
2011 Waxman EA, Giasson BI. Characterization of kinases involved in the phosphorylation of aggregated α-synuclein. Journal of Neuroscience Research. 89: 231-47. PMID 21162130 DOI: 10.1002/jnr.22537  1
2010 Goker-Alpan O, Stubblefield BK, Giasson BI, Sidransky E. Glucocerebrosidase is present in α-synuclein inclusions in Lewy body disorders. Acta Neuropathologica. 120: 641-9. PMID 20838799 DOI: 10.1007/s00401-010-0741-7  1
2010 Ramsey CP, Giasson BI. L10p and P158DEL DJ-1 mutations cause protein instability, aggregation, and dimerization impairments. Journal of Neuroscience Research. 88: 3111-24. PMID 20806408 DOI: 10.1002/jnr.22477  1
2010 Covy JP, Giasson BI. The G2019S pathogenic mutation disrupts sensitivity of leucine-rich repeat kinase 2 to manganese kinase inhibition. Journal of Neurochemistry. 115: 36-46. PMID 20626563 DOI: 10.1111/j.1471-4159.2010.06894.x  1
2010 Hao LY, Giasson BI, Bonini NM. DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function. Proceedings of the National Academy of Sciences of the United States of America. 107: 9747-52. PMID 20457924 DOI: 10.1073/pnas.0911175107  1
2010 Tsika E, Moysidou M, Guo J, Cushman M, Gannon P, Sandaltzopoulos R, Giasson BI, Krainc D, Ischiropoulos H, Mazzulli JR. Distinct region-specific alpha-synuclein oligomers in A53T transgenic mice: implications for neurodegeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 3409-18. PMID 20203200 DOI: 10.1523/JNEUROSCI.4977-09.2010  1
2010 Waxman EA, Giasson BI. A novel, high-efficiency cellular model of fibrillar alpha-synuclein inclusions and the examination of mutations that inhibit amyloid formation. Journal of Neurochemistry. 113: 374-88. PMID 20132485 DOI: 10.1111/j.1471-4159.2010.06592.x  1
2010 Kuo YM, Li Z, Jiao Y, Gaborit N, Pani AK, Orrison BM, Bruneau BG, Giasson BI, Smeyne RJ, Gershon MD, Nussbaum RL. Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated alpha-synuclein gene mutations precede central nervous system changes. Human Molecular Genetics. 19: 1633-50. PMID 20106867 DOI: 10.1093/hmg/ddq038  1
2010 Ramsey CP, Tsika E, Ischiropoulos H, Giasson BI. DJ-1 deficient mice demonstrate similar vulnerability to pathogenic Ala53Thr human alpha-syn toxicity. Human Molecular Genetics. 19: 1425-37. PMID 20089532 DOI: 10.1093/hmg/ddq017  1
2010 Ramsey CP, Giasson BI. Identification and characterization of a novel endogenous murine parkin mutation. Journal of Neurochemistry. 113: 402-17. PMID 20089136 DOI: 10.1111/j.1471-4159.2010.06605.x  1
2010 Waxman EA, Emmer KL, Giasson BI. Residue Glu83 plays a major role in negatively regulating alpha-synuclein amyloid formation. Biochemical and Biophysical Research Communications. 391: 1415-20. PMID 20026050 DOI: 10.1016/j.bbrc.2009.12.079  1
2009 Waxman EA, Mazzulli JR, Giasson BI. Characterization of hydrophobic residue requirements for alpha-synuclein fibrillization. Biochemistry. 48: 9427-36. PMID 19722699 DOI: 10.1021/bi900539p  1
2009 Waxman EA, Covy JP, Bukh I, Li X, Dawson TM, Giasson BI. Leucine-rich repeat kinase 2 expression leads to aggresome formation that is not associated with alpha-synuclein inclusions. Journal of Neuropathology and Experimental Neurology. 68: 785-96. PMID 19535993 DOI: 10.1097/NEN.0b013e3181aaf4fd  1
2009 Covy JP, Giasson BI. Identification of compounds that inhibit the kinase activity of leucine-rich repeat kinase 2. Biochemical and Biophysical Research Communications. 378: 473-7. PMID 19027715 DOI: 10.1016/j.bbrc.2008.11.048  1
2009 Covy JP, Yuan W, Waxman EA, Hurtig HI, Van Deerlin VM, Giasson BI. Clinical and pathological characteristics of patients with leucine-rich repeat kinase-2 mutations. Movement Disorders : Official Journal of the Movement Disorder Society. 24: 32-9. PMID 19006185 DOI: 10.1002/mds.22096  1
2009 Waxman EA, Giasson BI. Molecular mechanisms of alpha-synuclein neurodegeneration. Biochimica Et Biophysica Acta. 1792: 616-24. PMID 18955133 DOI: 10.1016/j.bbadis.2008.09.013  1
2009 Covy JP, Giasson BI. Corrigendum to "Identification of compounds that inhibit the kinase activity of leucine-rich repeat kinase 2" [Biochem. Biophys. Res. Commun. 378 (2009) 473-477] (DOI:10.1016/j.bbrc.2008.11.048) Biochemical and Biophysical Research Communications. 387: 419-420. DOI: 10.1016/j.bbrc.2009.06.066  1
2008 Ramsey CP, Giasson BI. The E163K DJ-1 mutant shows specific antioxidant deficiency. Brain Research. 1239: 1-11. PMID 18822273 DOI: 10.1016/j.brainres.2008.09.009  1
2008 Waxman EA, Giasson BI. Specificity and regulation of casein kinase-mediated phosphorylation of alpha-synuclein. Journal of Neuropathology and Experimental Neurology. 67: 402-16. PMID 18451726 DOI: 10.1097/NEN.0b013e31816fc995  1
2008 Waxman EA, Duda JE, Giasson BI. Characterization of antibodies that selectively detect alpha-synuclein in pathological inclusions. Acta Neuropathologica. 116: 37-46. PMID 18414880 DOI: 10.1007/s00401-008-0375-1  1
2008 Giasson BI, Van Deerlin VM. Mutations in LRRK2 as a cause of Parkinson's disease. Neuro-Signals. 16: 99-105. PMID 18097165 DOI: 10.1159/000109764  1
2008 Song WL, Lawson JA, Reilly D, Rokach J, Chang CT, Giasson B, FitzGerald GA. Neurofurans, novel indices of oxidant stress derived from docosahexaenoic acid. The Journal of Biological Chemistry. 283: 6-16. PMID 17921521 DOI: 10.1074/jbc.M706124200  1
2008 Klegeris A, Pelech S, Giasson BI, Maguire J, Zhang H, McGeer EG, McGeer PL. Alpha-synuclein activates stress signaling protein kinases in THP-1 cells and microglia. Neurobiology of Aging. 29: 739-52. PMID 17166628 DOI: 10.1016/j.neurobiolaging.2006.11.013  1
2007 Ramsey CP, Giasson BI. Role of mitochondrial dysfunction in Parkinson's disease: Implications for treatment. Drugs & Aging. 24: 95-105. PMID 17313198 DOI: 10.2165/00002512-200724020-00002  1
2007 Norris EH, Uryu K, Leight S, Giasson BI, Trojanowski JQ, Lee VM. Pesticide exposure exacerbates alpha-synucleinopathy in an A53T transgenic mouse model. The American Journal of Pathology. 170: 658-66. PMID 17255333 DOI: 10.2353/ajpath.2007.060359  1
2006 Beal MF, Bossy-Wetzel E, Finkbeiner S, Fiskum G, Giasson B, Johnson C, Khachaturian ZS, Lee VM, Nicholls D, Reddy H, Reynolds I, Teplow DB, Thal LJ, Trojanowski JQ, Walsh DM, et al. Common threads in neurodegenerative disorders of aging. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 2: 322-6. PMID 19595906 DOI: 10.1016/j.jalz.2006.08.008  1
2006 Klegeris A, Giasson BI, Zhang H, Maguire J, Pelech S, McGeer PL. Alpha-synuclein and its disease-causing mutants induce ICAM-1 and IL-6 in human astrocytes and astrocytoma cells. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 2000-8. PMID 17012252 DOI: 10.1096/fj.06-6183com  1
2006 Mazzulli JR, Mishizen AJ, Giasson BI, Lynch DR, Thomas SA, Nakashima A, Nagatsu T, Ota A, Ischiropoulos H. Cytosolic catechols inhibit alpha-synuclein aggregation and facilitate the formation of intracellular soluble oligomeric intermediates. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 10068-78. PMID 17005870 DOI: 10.1523/JNEUROSCI.0896-06.2006  1
2006 Goker-Alpan O, Giasson BI, Eblan MJ, Nguyen J, Hurtig HI, Lee VM, Trojanowski JQ, Sidransky E. Glucocerebrosidase mutations are an important risk factor for Lewy body disorders. Neurology. 67: 908-10. PMID 16790605 DOI: 10.1212/01.wnl.0000230215.41296.18  1
2006 Uryu K, Richter-Landsberg C, Welch W, Sun E, Goldbaum O, Norris EH, Pham CT, Yazawa I, Hilburger K, Micsenyi M, Giasson BI, Bonini NM, Lee VM, Trojanowski JQ. Convergence of heat shock protein 90 with ubiquitin in filamentous alpha-synuclein inclusions of alpha-synucleinopathies. The American Journal of Pathology. 168: 947-61. PMID 16507910 DOI: 10.2353/ajpath.2006.050770  1
2006 Giasson BI, Covy JP, Bonini NM, Hurtig HI, Farrer MJ, Trojanowski JQ, Van Deerlin VM. Biochemical and pathological characterization of Lrrk2. Annals of Neurology. 59: 315-22. PMID 16437584 DOI: 10.1002/ana.20791  1
2006 Covy JP, Van Deerlin VM, Giasson BI. Lack of evidence for Lrrk2 in α-synuclein pathological inclusions [4] Annals of Neurology. 60: 618-619. DOI: 10.1002/ana.21029  1
2005 Bonini NM, Giasson BI. Snaring the function of alpha-synuclein. Cell. 123: 359-61. PMID 16269324 DOI: 10.1016/j.cell.2005.10.017  1
2005 Meulener MC, Graves CL, Sampathu DM, Armstrong-Gold CE, Bonini NM, Giasson BI. DJ-1 is present in a large molecular complex in human brain tissue and interacts with alpha-synuclein. Journal of Neurochemistry. 93: 1524-32. PMID 15935068 DOI: 10.1111/j.1471-4159.2005.03145.x  1
2005 Mishizen-Eberz AJ, Norris EH, Giasson BI, Hodara R, Ischiropoulos H, Lee VM, Trojanowski JQ, Lynch DR. Cleavage of alpha-synuclein by calpain: potential role in degradation of fibrillized and nitrated species of alpha-synuclein. Biochemistry. 44: 7818-29. PMID 15909996 DOI: 10.1021/bi047846q  1
2005 Norris EH, Giasson BI. Role of oxidative damage in protein aggregation associated with Parkinson's disease and related disorders. Antioxidants & Redox Signaling. 7: 672-84. PMID 15890012 DOI: 10.1089/ars.2005.7.672  1
2005 Liu CW, Giasson BI, Lewis KA, Lee VM, Demartino GN, Thomas PJ. A precipitating role for truncated alpha-synuclein and the proteasome in alpha-synuclein aggregation: implications for pathogenesis of Parkinson disease. The Journal of Biological Chemistry. 280: 22670-8. PMID 15840579 DOI: 10.1074/jbc.M501508200  1
2005 Norris EH, Giasson BI, Hodara R, Xu S, Trojanowski JQ, Ischiropoulos H, Lee VM. Reversible inhibition of alpha-synuclein fibrillization by dopaminochrome-mediated conformational alterations. The Journal of Biological Chemistry. 280: 21212-9. PMID 15817478 DOI: 10.1074/jbc.M412621200  1
2005 Yazawa I, Giasson BI, Sasaki R, Zhang B, Joyce S, Uryu K, Trojanowski JQ, Lee VM. Mouse model of multiple system atrophy alpha-synuclein expression in oligodendrocytes causes glial and neuronal degeneration. Neuron. 45: 847-59. PMID 15797547 DOI: 10.1016/j.neuron.2005.01.032  1
2005 Greenbaum EA, Graves CL, Mishizen-Eberz AJ, Lupoli MA, Lynch DR, Englander SW, Axelsen PH, Giasson BI. The E46K mutation in alpha-synuclein increases amyloid fibril formation. The Journal of Biological Chemistry. 280: 7800-7. PMID 15632170 DOI: 10.1074/jbc.M411638200  1
2004 Giasson BI. Mitochondrial injury: a hot spot for parkinsonism and Parkinson's disease? Science of Aging Knowledge Environment : Sage Ke. 2004: pe42. PMID 15576821 DOI: 10.1126/sageke.2004.48.pe42  1
2004 Hodara R, Norris EH, Giasson BI, Mishizen-Eberz AJ, Lynch DR, Lee VM, Ischiropoulos H. Functional consequences of alpha-synuclein tyrosine nitration: diminished binding to lipid vesicles and increased fibril formation. The Journal of Biological Chemistry. 279: 47746-53. PMID 15364911 DOI: 10.1074/jbc.M408906200  1
2004 Kotzbauer PT, Giasson BI, Kravitz AV, Golbe LI, Mark MH, Trojanowski JQ, Lee VM. Fibrillization of alpha-synuclein and tau in familial Parkinson's disease caused by the A53T alpha-synuclein mutation. Experimental Neurology. 187: 279-88. PMID 15144854 DOI: 10.1016/j.expneurol.2004.01.007  1
2004 Wilson CA, Murphy DD, Giasson BI, Zhang B, Trojanowski JQ, Lee VM. Degradative organelles containing mislocalized alpha-and beta-synuclein proliferate in presenilin-1 null neurons. The Journal of Cell Biology. 165: 335-46. PMID 15123735 DOI: 10.1083/jcb.200403061  1
2004 Norris EH, Giasson BI, Lee VM. Alpha-synuclein: normal function and role in neurodegenerative diseases. Current Topics in Developmental Biology. 60: 17-54. PMID 15094295 DOI: 10.1016/S0070-2153(04)60002-0  1
2004 Lee VM, Giasson BI, Trojanowski JQ. More than just two peas in a pod: common amyloidogenic properties of tau and alpha-synuclein in neurodegenerative diseases. Trends in Neurosciences. 27: 129-34. PMID 15036877 DOI: 10.1016/j.tins.2004.01.007  1
2004 Giasson BI, Lee VMY, Trojanowski JQ. Animal models of neurodegenerative dementing disorders other than Alzheimer's disease Clinical Neuroscience Research. 3: 427-436. DOI: 10.1016/j.cnr.2004.04.008  1
2003 Uryu K, Giasson BI, Longhi L, Martinez D, Murray I, Conte V, Nakamura M, Saatman K, Talbot K, Horiguchi T, McIntosh T, Lee VM, Trojanowski JQ. Age-dependent synuclein pathology following traumatic brain injury in mice. Experimental Neurology. 184: 214-24. PMID 14637093 DOI: 10.1016/S0014-4886(03)00245-0  1
2003 Giasson BI, Lee VM, Trojanowski JQ. Interactions of amyloidogenic proteins. Neuromolecular Medicine. 4: 49-58. PMID 14528052 DOI: 10.1385/NMM:4:1-2:49  1
2003 Pawlyk AC, Giasson BI, Sampathu DM, Perez FA, Lim KL, Dawson VL, Dawson TM, Palmiter RD, Trojanowski JQ, Lee VM. Novel monoclonal antibodies demonstrate biochemical variation of brain parkin with age. The Journal of Biological Chemistry. 278: 48120-8. PMID 12972409 DOI: 10.1074/jbc.M306889200  1
2003 Crystal AS, Giasson BI, Crowe A, Kung MP, Zhuang ZP, Trojanowski JQ, Lee VM. A comparison of amyloid fibrillogenesis using the novel fluorescent compound K114. Journal of Neurochemistry. 86: 1359-68. PMID 12950445 DOI: 10.1046/j.1471-4159.2003.01949.x  1
2003 Horiguchi T, Uryu K, Giasson BI, Ischiropoulos H, LightFoot R, Bellmann C, Richter-Landsberg C, Lee VM, Trojanowski JQ. Nitration of tau protein is linked to neurodegeneration in tauopathies. The American Journal of Pathology. 163: 1021-31. PMID 12937143 DOI: 10.1016/S0002-9440(10)63462-1  1
2003 Mishizen-Eberz AJ, Guttmann RP, Giasson BI, Day GA, Hodara R, Ischiropoulos H, Lee VM, Trojanowski JQ, Lynch DR. Distinct cleavage patterns of normal and pathologic forms of alpha-synuclein by calpain I in vitro. Journal of Neurochemistry. 86: 836-47. PMID 12887682 DOI: 10.1046/j.1471-4159.2003.01878.x  1
2003 Giasson BI, Lee VM. Are ubiquitination pathways central to Parkinson's disease? Cell. 114: 1-8. PMID 12859888 DOI: 10.1016/S0092-8674(03)00509-9  1
2003 Murray IV, Giasson BI, Quinn SM, Koppaka V, Axelsen PH, Ischiropoulos H, Trojanowski JQ, Lee VM. Role of alpha-synuclein carboxy-terminus on fibril formation in vitro. Biochemistry. 42: 8530-40. PMID 12859200 DOI: 10.1021/bi027363r  1
2003 Norris EH, Giasson BI, Ischiropoulos H, Lee VM. Effects of oxidative and nitrative challenges on alpha-synuclein fibrillogenesis involve distinct mechanisms of protein modifications. The Journal of Biological Chemistry. 278: 27230-40. PMID 12857790 DOI: 10.1074/jbc.M212436200  1
2003 Sampathu DM, Giasson BI, Pawlyk AC, Trojanowski JQ, Lee VM. Ubiquitination of alpha-synuclein is not required for formation of pathological inclusions in alpha-synucleinopathies. The American Journal of Pathology. 163: 91-100. PMID 12819014  1
2003 Giasson BI, Mabon ME, Duda JE, Montine TJ, Robertson D, Hurtig HI, Lee VM, Trojanowski JQ. Tau and 14-3-3 in glial cytoplasmic inclusions of multiple system atrophy. Acta Neuropathologica. 106: 243-50. PMID 12811584 DOI: 10.1007/s00401-003-0726-x  1
2003 Fung KM, Rorke LB, Giasson B, Lee VM, Trojanowski JQ. Expression of alpha-, beta-, and gamma-synuclein in glial tumors and medulloblastomas. Acta Neuropathologica. 106: 167-75. PMID 12783249 DOI: 10.1007/s00401-003-0718-x  1
2003 Giasson BI, Forman MS, Higuchi M, Golbe LI, Graves CL, Kotzbauer PT, Trojanowski JQ, Lee VM. Initiation and synergistic fibrillization of tau and alpha-synuclein. Science (New York, N.Y.). 300: 636-40. PMID 12714745 DOI: 10.1126/science.1082324  1
2003 Duda JE, Giasson BI, Lee VMY, Trojanowski JQ. Is the initial insult in Parkinson's disease and dementia with Lewy bodies a neuritic dystrophy? Annals of the New York Academy of Sciences. 991: 295-297.  1
2002 Giasson BI, Sampathu DM, Wilson CA, Vogelsberg-Ragaglia V, Mushynski WE, Lee VM. The environmental toxin arsenite induces tau hyperphosphorylation. Biochemistry. 41: 15376-87. PMID 12484777 DOI: 10.1021/bi026813c  1
2002 Neumann M, Kahle PJ, Giasson BI, Ozmen L, Borroni E, Spooren W, Müller V, Odoy S, Fujiwara H, Hasegawa M, Iwatsubo T, Trojanowski JQ, Kretzschmar HA, Haass C. Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies. The Journal of Clinical Investigation. 110: 1429-39. PMID 12438441 DOI: 10.1172/JCI15777  1
2002 Duda JE, Giasson BI, Mabon ME, Lee VM, Trojanowski JQ. Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases. Annals of Neurology. 52: 205-10. PMID 12210791 DOI: 10.1002/ana.10279  1
2002 Liu HN, Giasson BI, Mushynski WE, Almazan G. AMPA receptor-mediated toxicity in oligodendrocyte progenitors involves free radical generation and activation of JNK, calpain and caspase 3. Journal of Neurochemistry. 82: 398-409. PMID 12124441 DOI: 10.1046/j.1471-4159.2002.00981.x  1
2002 Pan ZZ, Bruening W, Giasson BI, Lee VM, Godwin AK. Gamma-synuclein promotes cancer cell survival and inhibits stress- and chemotherapy drug-induced apoptosis by modulating MAPK pathways. The Journal of Biological Chemistry. 277: 35050-60. PMID 12121974 DOI: 10.1074/jbc.M201650200  1
2002 Duda JE, Giasson BI, Mabon ME, Miller DC, Golbe LI, Lee VM, Trojanowski JQ. Concurrence of alpha-synuclein and tau brain pathology in the Contursi kindred. Acta Neuropathologica. 104: 7-11. PMID 12070658 DOI: 10.1007/s00401-002-0563-3  1
2002 Giasson BI, Duda JE, Quinn SM, Zhang B, Trojanowski JQ, Lee VM. Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein. Neuron. 34: 521-33. PMID 12062037 DOI: 10.1016/S0896-6273(02)00682-7  1
2002 Giasson BI, Ischiropoulos H, Lee VM, Trojanowski JQ. The relationship between oxidative/nitrative stress and pathological inclusions in Alzheimer's and Parkinson's diseases. Free Radical Biology & Medicine. 32: 1264-75. PMID 12057764 DOI: 10.1016/S0891-5849(02)00804-3  1
2001 Giasson BI, Duda JE, Forman MS, Lee VM, Trojanowski JQ. Prominent perikaryal expression of alpha- and beta-synuclein in neurons of dorsal root ganglion and in medullary neurons. Experimental Neurology. 172: 354-62. PMID 11716559 DOI: 10.1006/exnr.2001.7805  1
2001 Paxinou E, Chen Q, Weisse M, Giasson BI, Norris EH, Rueter SM, Trojanowski JQ, Lee VM, Ischiropoulos H. Induction of alpha-synuclein aggregation by intracellular nitrative insult. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 8053-61. PMID 11588178  1
2001 Giasson BI, Lee VM. Parkin and the molecular pathways of Parkinson's disease. Neuron. 31: 885-8. PMID 11580890 DOI: 10.1016/S0896-6273(01)00439-1  1
2001 Schmidt ML, Schuck T, Sheridan S, Kung MP, Kung H, Zhuang ZP, Bergeron C, Lamarche JS, Skovronsky D, Giasson BI, Lee VM, Trojanowski JQ. The fluorescent Congo red derivative, (trans, trans)-1-bromo-2,5-bis-(3-hydroxycarbonyl-4-hydroxy)styrylbenzene (BSB), labels diverse beta-pleated sheet structures in postmortem human neurodegenerative disease brains. The American Journal of Pathology. 159: 937-43. PMID 11549586  1
2001 Perry G, Avila J, Espey MG, Wink DA, Atwood CS, Smith MA. Biochemistry of neurodegeneration. Science (New York, N.Y.). 291: 595-7. PMID 11229401  1
2001 Przedborski S, Chen Q, Vila M, Giasson BI, Djaldatti R, Vukosavic S, Souza JM, Jackson-Lewis V, Lee VM, Ischiropoulos H. Oxidative post-translational modifications of alpha-synuclein in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease. Journal of Neurochemistry. 76: 637-40. PMID 11208927 DOI: 10.1046/j.1471-4159.2001.00174.x  1
2001 Giasson BI, Murray IV, Trojanowski JQ, Lee VM. A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly. The Journal of Biological Chemistry. 276: 2380-6. PMID 11060312 DOI: 10.1074/jbc.M008919200  1
2000 Giasson BI, Lee VM. A new link between pesticides and Parkinson's disease. Nature Neuroscience. 3: 1227-8. PMID 11100135 DOI: 10.1038/81737  1
2000 Duda JE, Giasson BI, Chen Q, Gur TL, Hurtig HI, Stern MB, Gollomp SM, Ischiropoulos H, Lee VM, Trojanowski JQ. Widespread nitration of pathological inclusions in neurodegenerative synucleinopathies. The American Journal of Pathology. 157: 1439-45. PMID 11073803 DOI: 10.1016/S0002-9440(10)64781-5  1
2000 Giasson BI, Duda JE, Murray IV, Chen Q, Souza JM, Hurtig HI, Ischiropoulos H, Trojanowski JQ, Lee VM. Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions. Science (New York, N.Y.). 290: 985-9. PMID 11062131 DOI: 10.1126/science.290.5493.985  1
2000 Duda JE, Giasson BI, Gur TL, Montine TJ, Robertson D, Biaggioni I, Hurtig HI, Stern MB, Gollomp SM, Grossman M, Lee VM, Trojanowski JQ. Immunohistochemical and biochemical studies demonstrate a distinct profile of alpha-synuclein permutations in multiple system atrophy. Journal of Neuropathology and Experimental Neurology. 59: 830-41. PMID 11005264  1
2000 Galvin JE, Giasson B, Hurtig HI, Lee VM, Trojanowski JQ. Neurodegeneration with brain iron accumulation, type 1 is characterized by alpha-, beta-, and gamma-synuclein neuropathology. The American Journal of Pathology. 157: 361-8. PMID 10934140  1
2000 Souza JM, Giasson BI, Lee VM, Ischiropoulos H. Chaperone-like activity of synucleins. Febs Letters. 474: 116-9. PMID 10828462 DOI: 10.1016/S0014-5793(00)01563-5  1
2000 Bruening W, Giasson BI, Klein-Szanto AJ, Lee VM, Trojanowski JQ, Godwin AK. Synucleins are expressed in the majority of breast and ovarian carcinomas and in preneoplastic lesions of the ovary. Cancer. 88: 2154-63. PMID 10813729 DOI: 10.1002/(SICI)1097-0142(20000501)88:9<2154::AID-CNCR23>3.0.CO;2-9  1
2000 Souza JM, Giasson BI, Chen Q, Lee VM, Ischiropoulos H. Dityrosine cross-linking promotes formation of stable alpha -synuclein polymers. Implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies. The Journal of Biological Chemistry. 275: 18344-9. PMID 10747881 DOI: 10.1074/jbc.M000206200  1
2000 Giasson BI, Jakes R, Goedert M, Duda JE, Leight S, Trojanowski JQ, Lee VM. A panel of epitope-specific antibodies detects protein domains distributed throughout human alpha-synuclein in Lewy bodies of Parkinson's disease. Journal of Neuroscience Research. 59: 528-33. PMID 10679792 DOI: 10.1002/(SICI)1097-4547(20000215)59:4<528::AID-JNR8>3.0.CO;2-0  1
1999 Giasson BI, Uryu K, Trojanowski JQ, Lee VM. Mutant and wild type human alpha-synucleins assemble into elongated filaments with distinct morphologies in vitro. The Journal of Biological Chemistry. 274: 7619-22. PMID 10075647 DOI: 10.1074/jbc.274.12.7619  1
1999 Giasson BI, Bruening W, Durham HD, Mushynski WE. Activation of stress-activated protein kinases correlates with neurite outgrowth induced by protease inhibition in PC12 cells. Journal of Neurochemistry. 72: 1081-7. PMID 10037479 DOI: 10.1046/j.1471-4159.1999.0721081.x  1
1998 Giasson BI, Mushynski WE. Intermediate filament disassembly in cultured dorsal root ganglion neurons is associated with amino-terminal head domain phosphorylation of specific subunits. Journal of Neurochemistry. 70: 1869-75. PMID 9572270  1
1997 Giasson BI, Mushynski WE. Study of proline-directed protein kinases involved in phosphorylation of the heavy neurofilament subunit. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 9466-72. PMID 9391002  1
1997 Giasson BI, Mushynski WE. Developmentally regulated stabilization of neuronal intermediate filaments in rat cerebral cortex. Neuroscience Letters. 229: 77-80. PMID 9223595 DOI: 10.1016/S0304-3940(97)00425-4  1
1997 Giasson BI, Mushynski WE. Okadaic acid reversibly inhibits neurite outgrowth in embryonic dorsal root ganglion neurons. Journal of Neurobiology. 32: 193-201. PMID 9032661 DOI: 10.1002/(SICI)1097-4695(199702)32:2<193::AID-NEU4>3.0.CO;2-3  1
1996 Giasson BI, Mushynski WE. Aberrant stress-induced phosphorylation of perikaryal neurofilaments. The Journal of Biological Chemistry. 271: 30404-9. PMID 8940004 DOI: 10.1074/jbc.271.48.30404  1
1996 Giasson BI, Cromlish JA, Athlan ES, Mushynski WE. Activation of cyclic AMP-dependent protein kinase in okadaic acid-treated neurons potentiates neurofilament fragmentation and stimulates phosphorylation of Ser2 in the low-molecular-mass neurofilament subunit. Journal of Neurochemistry. 66: 1207-13. PMID 8769885  1
1995 Jayaraman D, Giasson BI, Mushynski WE. Increased phosphorylation of neurofilament subunits in PC12 cells and rat dorsal root ganglion neurons treated with N-Acetyl-Leu-Leu-norleucinal. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. 13: 753-8. PMID 8787865 DOI: 10.1016/0736-5748(95)00060-7  1
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