Larry Simpson - Publications

Affiliations: 
University of California, Los Angeles, Los Angeles, CA 
Website:
http://dna.kdna.ucla.edu/simpsonlab/

135 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Aphasizheva I, Alfonzo J, Carnes J, Cestari I, Cruz-Reyes J, Göringer HU, Hajduk S, Lukeš J, Madison-Antenucci S, Maslov DA, McDermott SM, Ochsenreiter T, Read LK, Salavati R, Schnaufer A, ... ... Simpson L, et al. Lexis and Grammar of Mitochondrial RNA Processing in Trypanosomes. Trends in Parasitology. 36: 337-355. PMID 32191849 DOI: 10.1016/J.Pt.2020.01.006  0.522
2015 Wong RG, Kazane K, Maslov DA, Rogers K, Aphasizhev R, Simpson L. U-insertion/deletion RNA editing multiprotein complexes and mitochondrial ribosomes in Leishmania tarentolae are located in antipodal nodes adjacent to the kinetoplast DNA. Mitochondrion. 25: 76-86. PMID 26462764 DOI: 10.1016/J.Mito.2015.10.006  0.668
2015 Simpson L, Douglass SM, Lake JA, Pellegrini M, Li F. Comparison of the Mitochondrial Genomes and Steady State Transcriptomes of Two Strains of the Trypanosomatid Parasite, Leishmania tarentolae. Plos Neglected Tropical Diseases. 9: e0003841. PMID 26204118 DOI: 10.1371/Journal.Pntd.0003841  0.514
2015 Simpson L. The most unlikely places. Rna (New York, N.Y.). 21: 740-1. PMID 25780216 DOI: 10.1261/Rna.050088.115  0.522
2012 Eckers E, Cyrklaff M, Simpson L, Deponte M. Mitochondrial protein import pathways are functionally conserved among eukaryotes despite compositional diversity of the import machineries. Biological Chemistry. 393: 513-24. PMID 22628314 DOI: 10.1515/Hsz-2011-0255  0.394
2011 Li F, Herrera J, Zhou S, Maslov DA, Simpson L. Trypanosome REH1 is an RNA helicase involved with the 3'-5' polarity of multiple gRNA-guided uridine insertion/deletion RNA editing. Proceedings of the National Academy of Sciences of the United States of America. 108: 3542-7. PMID 21321231 DOI: 10.1073/Pnas.1014152108  0.505
2010 Gao G, Rogers K, Li F, Guo Q, Osato D, Zhou SX, Falick AM, Simpson L. Uridine insertion/deletion RNA editing in Trypanosomatids: specific stimulation in vitro of Leishmania tarentolae REL1 RNA ligase activity by the MP63 zinc finger protein. Protist. 161: 489-96. PMID 20138580 DOI: 10.1016/J.Protis.2010.01.001  0.676
2010 Simpson L, Aphasizhev R, Lukes J, Cruz-Reyes J. Guide to the nomenclature of kinetoplastid RNA editing: a proposal. Protist. 161: 2-6. PMID 19945343 DOI: 10.1016/J.Protis.2009.10.001  0.417
2009 Li F, Ge P, Hui WH, Atanasov I, Rogers K, Guo Q, Osato D, Falick AM, Zhou ZH, Simpson L. Structure of the core editing complex (L-complex) involved in uridine insertion/deletion RNA editing in trypanosomatid mitochondria. Proceedings of the National Academy of Sciences of the United States of America. 106: 12306-10. PMID 19590014 DOI: 10.1073/Pnas.0901754106  0.63
2009 Sharma MR, Booth TM, Simpson L, Maslov DA, Agrawal RK. Structure of a mitochondrial ribosome with minimal RNA. Proceedings of the National Academy of Sciences of the United States of America. 106: 9637-42. PMID 19497863 DOI: 10.1073/Pnas.0901631106  0.479
2009 Osato D, Rogers K, Guo Q, Li F, Richmond G, Klug F, Simpson L. Uridine insertion/deletion RNA editing in trypanosomatid mitochondria: In search of the editosome. Rna (New York, N.Y.). 15: 1338-44. PMID 19447916 DOI: 10.1261/Rna.1642809  0.592
2009 Nebohácová M, Kim CE, Simpson L, Maslov DA. RNA editing and mitochondrial activity in promastigotes and amastigotes of Leishmania donovani. International Journal For Parasitology. 39: 635-44. PMID 19109964 DOI: 10.1016/J.Ijpara.2008.10.015  0.525
2008 Jensen RE, Simpson L, Englund PT. What happens when Trypanosoma brucei leaves Africa. Trends in Parasitology. 24: 428-31. PMID 18715829 DOI: 10.1016/J.Pt.2008.06.007  0.306
2007 Rogers K, Gao G, Simpson L. Uridylate-specific 3' 5'-exoribonucleases involved in uridylate-deletion RNA editing in trypanosomatid mitochondria. The Journal of Biological Chemistry. 282: 29073-80. PMID 17699520 DOI: 10.1074/Jbc.M704551200  0.696
2007 Maslov DA, Simpson L. Strategies of kinetoplastid cryptogene discovery and analysis. Methods in Enzymology. 424: 127-39. PMID 17662839 DOI: 10.1016/S0076-6879(07)24006-6  0.413
2007 Maslov DA, Spremulli LL, Sharma MR, Bhargava K, Grasso D, Falick AM, Agrawal RK, Parker CE, Simpson L. Proteomics and electron microscopic characterization of the unusual mitochondrial ribosome-related 45S complex in Leishmania tarentolae. Molecular and Biochemical Parasitology. 152: 203-12. PMID 17292489 DOI: 10.1016/J.Molbiopara.2007.01.012  0.374
2006 Kang X, Gao G, Rogers K, Falick AM, Zhou S, Simpson L. Reconstitution of full-round uridine-deletion RNA editing with three recombinant proteins. Proceedings of the National Academy of Sciences of the United States of America. 103: 13944-9. PMID 16963561 DOI: 10.1073/Pnas.0604476103  0.677
2006 Maslov DA, Sharma MR, Butler E, Falick AM, Gingery M, Agrawal RK, Spremulli LL, Simpson L. Isolation and characterization of mitochondrial ribosomes and ribosomal subunits from Leishmania tarentolae. Molecular and Biochemical Parasitology. 148: 69-78. PMID 16600399 DOI: 10.1016/J.Molbiopara.2006.02.021  0.37
2006 Simpson L. 14 Uridine Insertion/Deletion RNA Editing as a Paradigm for Site-specific Modifications of RNA Molecules Cold Spring Harbor Monograph Archive. 43: 401-417. DOI: 10.1101/087969739.43.401  0.368
2005 Gao G, Simpson AM, Kang X, Rogers K, Nebohacova M, Li F, Simpson L. Functional complementation of Trypanosoma brucei RNA in vitro editing with recombinant RNA ligase. Proceedings of the National Academy of Sciences of the United States of America. 102: 4712-7. PMID 15781861 DOI: 10.1073/Pnas.0500553102  0.658
2005 Kang X, Rogers K, Gao G, Falick AM, Zhou S, Simpson L. Reconstitution of uridine-deletion precleaved RNA editing with two recombinant enzymes. Proceedings of the National Academy of Sciences of the United States of America. 102: 1017-22. PMID 15657144 DOI: 10.1073/Pnas.0409275102  0.682
2004 Aphasizhev R, Aphasizheva I, Simpson L. Multiple terminal uridylyltransferases of trypanosomes. Febs Letters. 572: 15-8. PMID 15304317 DOI: 10.1016/J.Febslet.2004.07.004  0.428
2004 Aphasizheva I, Aphasizhev R, Simpson L. RNA-editing terminal uridylyl transferase 1: identification of functional domains by mutational analysis. The Journal of Biological Chemistry. 279: 24123-30. PMID 15060068 DOI: 10.1074/Jbc.M401234200  0.457
2004 Simpson L, Aphasizhev R, Gao G, Kang X. Mitochondrial proteins and complexes in Leishmania and Trypanosoma involved in U-insertion/deletion RNA editing. Rna (New York, N.Y.). 10: 159-70. PMID 14730014 DOI: 10.1261/Rna.5170704  0.467
2004 Nebohácová M, Maslov DA, Falick AM, Simpson L. The effect of RNA interference Down-regulation of RNA editing 3'-terminal uridylyl transferase (TUTase) 1 on mitochondrial de novo protein synthesis and stability of respiratory complexes in Trypanosoma brucei. The Journal of Biological Chemistry. 279: 7819-25. PMID 14681226 DOI: 10.1074/Jbc.M311360200  0.496
2004 Kang X, Falick AM, Nelson RE, Gao G, Rogers K, Aphasizhev R, Simpson L. Disruption of the zinc finger motifs in the Leishmania tarentolae LC-4 (=TbMP63) L-complex editing protein affects the stability of the L-complex. The Journal of Biological Chemistry. 279: 3893-9. PMID 14604987 DOI: 10.1074/Jbc.M310185200  0.559
2003 Hong M, Simpson L. Genomic organization of Trypanosoma brucei kinetoplast DNA minicircles. Protist. 154: 265-79. PMID 13677453 DOI: 10.1078/143446103322166554  0.363
2003 Aphasizhev R, Aphasizheva I, Simpson L. A tale of two TUTases. Proceedings of the National Academy of Sciences of the United States of America. 100: 10617-22. PMID 12954983 DOI: 10.1073/Pnas.1833120100  0.531
2003 Sbicego S, Alfonzo JD, Estévez AM, Rubio MA, Kang X, Turck CW, Peris M, Simpson L. RBP38, a novel RNA-binding protein from trypanosomatid mitochondria, modulates RNA stability. Eukaryotic Cell. 2: 560-8. PMID 12796301 DOI: 10.1128/Ec.2.3.560-568.2003  0.687
2003 Gao G, Simpson L. Is the Trypanosoma brucei REL1 RNA ligase specific for U-deletion RNA editing, and is the REL2 RNA ligase specific for U-insertion editing? The Journal of Biological Chemistry. 278: 27570-4. PMID 12748175 DOI: 10.1074/Jbc.M303317200  0.487
2003 Simpson L, Sbicego S, Aphasizhev R. Uridine insertion/deletion RNA editing in trypanosome mitochondria: a complex business. Rna (New York, N.Y.). 9: 265-76. PMID 12591999 DOI: 10.1261/Rna.2178403  0.479
2003 Aphasizhev R, Aphasizheva I, Nelson RE, Gao G, Simpson AM, Kang X, Falick AM, Sbicego S, Simpson L. Isolation of a U-insertion/deletion editing complex from Leishmania tarentolae mitochondria. The Embo Journal. 22: 913-24. PMID 12574127 DOI: 10.1093/Emboj/Cdg083  0.493
2003 Aphasizhev R, Aphasizheva I, Nelson RE, Simpson L. A 100-kD complex of two RNA-binding proteins from mitochondria of Leishmania tarentolae catalyzes RNA annealing and interacts with several RNA editing components. Rna (New York, N.Y.). 9: 62-76. PMID 12554877 DOI: 10.1261/Rna.2134303  0.465
2003 Kaneko T, Suzuki T, Kapushoc ST, Rubio MA, Ghazvini J, Watanabe K, Simpson L, Suzuki T. Wobble modification differences and subcellular localization of tRNAs in Leishmania tarentolae: implication for tRNA sorting mechanism. The Embo Journal. 22: 657-67. PMID 12554666 DOI: 10.1093/Emboj/Cdg066  0.786
2002 Monzani PS, Alfonzo JD, Simpson L, Oliva G, Thiemann OH. Cloning, characterization and preliminary crystallographic analysis of Leishmania hypoxanthine-guanine phosphoribosyltransferase. Biochimica Et Biophysica Acta. 1598: 3-9. PMID 12147338 DOI: 10.1016/S0167-4838(02)00334-5  0.313
2002 Crain PF, Alfonzo JD, Rozenski J, Kapushoc ST, McCloskey JA, Simpson L. Modification of the universally unmodified uridine-33 in a mitochondria-imported edited tRNA and the role of the anticodon arm structure on editing efficiency. Rna (New York, N.Y.). 8: 752-61. PMID 12088148 DOI: 10.1017/S1355838202022045  0.79
2002 Aphasizhev R, Sbicego S, Peris M, Jang SH, Aphasizheva I, Simpson AM, Rivlin A, Simpson L. Trypanosome mitochondrial 3' terminal uridylyl transferase (TUTase): the key enzyme in U-insertion/deletion RNA editing. Cell. 108: 637-48. PMID 11893335 DOI: 10.1016/S0092-8674(02)00647-5  0.503
2002 Kapushoc ST, Alfonzo JD, Simpson L. Differential localization of nuclear-encoded tRNAs between the cytosol and mitochondrion in Leishmania tarentolae. Rna (New York, N.Y.). 8: 57-68. PMID 11871660 DOI: 10.1017/S1355838202012281  0.799
2001 Gao G, Kapushoc ST, Simpson AM, Thiemann OH, Simpson L. Guide RNAs of the recently isolated LEM125 strain of Leishmania tarentolae: an unexpected complexity. Rna (New York, N.Y.). 7: 1335-47. PMID 11565754 DOI: 10.1017/S1355838201018076  0.785
2001 Aphasizhev R, Simpson L. Isolation and Characterization of a U-specific 3′5′ -Exonuclease from Mitochondria of Leishmania tarentolae Journal of Biological Chemistry. 276: 21280-21284. PMID 11279235 DOI: 10.1074/Jbc.M100297200  0.515
2001 Carrillo R, Thiemann OH, Alfonzo JD, Simpson L. Uridine insertion/deletion RNA editing in Leishmania tarentolae mitochondria shows cell cycle dependence Molecular and Biochemical Parasitology. 113: 175-181. PMID 11254966 DOI: 10.1016/S0166-6851(00)00385-6  0.317
2000 Kapushoc ST, Alfonzo JD, Rubio MA, Simpson L. End processing precedes mitochondrial importation and editing of tRNAs in Leishmania tarentolae. The Journal of Biological Chemistry. 275: 37907-14. PMID 10993905 DOI: 10.1074/Jbc.M007838200  0.787
2000 Rubio MA, Liu X, Yuzawa H, Alfonzo JD, Simpson L. Selective importation of RNA into isolated mitochondria from Leishmania tarentolae. Rna (New York, N.Y.). 6: 988-1003. PMID 10917595 DOI: 10.1017/S1355838200991519  0.706
2000 Simpson L, Thiemann OH, Savill NJ, Alfonzo JD, Maslov DA. Evolution of RNA editing in trypanosome mitochondria Proceedings of the National Academy of Sciences of the United States of America. 97: 6986-6993. PMID 10860961 DOI: 10.1073/Pnas.97.13.6986  0.502
1999 Maslov DA, Yasuhira S, Simpson L. Phylogenetic affinities of Diplonema within the Euglenozoa as inferred from the SSU rRNA gene and partial COI protein sequences. Protist. 150: 33-42. PMID 10724517 DOI: 10.1016/S1434-4610(99)70007-6  0.377
1999 Alfonzo JD, Blanc V, Estévez AM, Rubio MA, Simpson L. C to U editing of the anticodon of imported mitochondrial tRNA(Trp) allows decoding of the UGA stop codon in Leishmania tarentolae. The Embo Journal. 18: 7056-62. PMID 10601027 DOI: 10.1093/Emboj/18.24.7056  0.678
1999 Estévez AM, Simpson L. Uridine insertion/deletion RNA editing in trypanosome mitochondria - A review Gene. 240: 247-260. PMID 10580144 DOI: 10.1016/S0378-1119(99)00437-0  0.539
1999 Estévez AM, Thiemann OH, Alfonzo JD, Simpson L. T7 RNA polymerase-driven transcription in mitochondria of Leishmania tarentolae and Trypanosoma brucei Molecular and Biochemical Parasitology. 103: 251-259. PMID 10551367 DOI: 10.1016/S0166-6851(99)00139-5  0.484
1999 Blanc V, Alfonzo JD, Aphasizhev R, Simpson L. The mitochondrial RNA ligase from Leishmania tarentolae can join RNA molecules bridged by a complementary RNA Journal of Biological Chemistry. 274: 24289-24296. PMID 10446205 DOI: 10.1074/Jbc.274.34.24289  0.499
1999 Simpson L, Maslov DA. Evolution of the U-insertion/deletion RNA editing in mitochondria of kinetoplastid protozoa Annals of the New York Academy of Sciences. 870: 190-205. PMID 10415483 DOI: 10.1111/J.1749-6632.1999.Tb08879.X  0.512
1999 Estévez AM, Kierszenbaum F, Wirtz E, Bringaud F, Grunstein J, Simpson L. Knockout of the glutamate dehydrogenase gene in bloodstream Trypanosoma brucei in culture has no effect on editing of mitochondrial mRNAs Molecular and Biochemical Parasitology. 100: 5-17. PMID 10376989 DOI: 10.1016/S0166-6851(99)00024-9  0.496
1999 Kapushoc ST, Simpson L. In vitro uridine insertion RNA editing mediated by cis-acting guide RNAs. Rna (New York, N.Y.). 5: 656-69. PMID 10334336 DOI: 10.1017/S1355838299982250  0.793
1999 Simpson L. 22 RNA Editing—An Evolutionary Perspective Cold Spring Harbor Monograph Archive. 37: 585-608. DOI: 10.1101/087969589.37.585  0.541
1998 Alfonzo JD, Thiemann OH, Simpson L. Purification and characterization of MAR1. A mitochondrial associated ribonuclease from Leishmania tarentolae Journal of Biological Chemistry. 273: 30003-30011. PMID 9792721 DOI: 10.1074/Jbc.273.45.30003  0.542
1998 Aphasizhev R, Karmarkar U, Simpson L. Are tRNAs imported into the mitochondria of kinetoplastid protozoa as 5'-extended precursors? Molecular and Biochemical Parasitology. 93: 73 - 80. PMID 9662029 DOI: 10.1016/S0166-6851(98)00022-X  0.472
1998 Simpson L. A base called J Proceedings of the National Academy of Sciences of the United States of America. 95: 2037-2038. PMID 9482833 DOI: 10.1073/Pnas.95.5.2037  0.301
1998 Simpson L, Wang SH, Thiemann OH, Alfonzo JD, Maslov DA, Avila HA. U-insertion/deletion Edited Sequence Database Nucleic Acids Research. 26: 170-176. PMID 9399827 DOI: 10.1093/Nar/26.1.170  0.488
1998 Connell GJ, Simpson L. Role of RNA Structure in RNA Editing Cold Spring Harbor Monograph Archive. 35: 641-667. DOI: 10.1101/087969509.35.641  0.44
1997 Alfonzo JD, Thiemann O, Simpson L. The mechanism of U insertion/deletion RNA editing in kinetoplastid mitochondria Nucleic Acids Research. 25: 3751-3759. PMID 9380494 DOI: 10.1093/Nar/25.19.3751  0.504
1997 Simpson L, Kretzer F. The mitochondrion in dividing Leishmania tarentolae cells is symmetric and circular and becomes a single asymmetric tubule in non-dividing cells due to division of the kinetoplast portion Molecular and Biochemical Parasitology. 87: 71-78. PMID 9233674 DOI: 10.1016/S0166-6851(97)00044-3  0.361
1997 Simpson L. The genomic organization of guide RNA genes in kinetoplastid protozoa: Several conundrums and their solutions Molecular and Biochemical Parasitology. 86: 133-141. PMID 9200120 DOI: 10.1016/S0166-6851(97)00037-6  0.472
1997 Bringaud F, Stripecke R, Frech GC, Freedland S, Turck C, Byrne EM, Simpson L. Mitochondrial glutamate dehydrogenase from Leishmania tarentolae is a guide RNA-binding protein Molecular and Cellular Biology. 17: 3915-3923. PMID 9199326 DOI: 10.1128/Mcb.17.7.3915  0.494
1997 Peris M, Simpson AM, Grunstein J, Liliental JE, Frech GC, Simpson L. Native gel analysis of ribonucleoprotein complexes from a Leishmania tarentolae mitochondrial extract Molecular and Biochemical Parasitology. 85: 9-24. PMID 9108545 DOI: 10.1016/S0166-6851(96)02795-8  0.439
1997 Yasuhira S, Simpson L. Phylogenetic affinity of mitochondria of Euglena gracilis and kinetoplastids using cytochrome oxidase I and hsp60. Journal of Molecular Evolution. 44: 341-7. PMID 9060401 DOI: 10.1007/Pl00006152  0.527
1997 Connell GJ, Byrne EM, Simpson L. Guide RNA-independent and guide RNA-dependent uridine insertion into cytochrome b mRNA in a mitochondrial lysate from Leishmania tarentolae. Role of RNA secondary structure Journal of Biological Chemistry. 272: 4212-4218. PMID 9020135 DOI: 10.1074/Jbc.272.7.4212  0.501
1996 Byrne EM, Connell GJ, Simpson L. Guide RNA-directed uridine insertion RNA editing in vitro Embo Journal. 15: 6758-6765. PMID 8978701 DOI: 10.1002/J.1460-2075.1996.Tb01065.X  0.493
1996 Simpson L, Frech GC, Maslov DA. [10] RNA editing in trypanosomatid mitochondria Methods in Enzymology. 264: 99-121. PMID 8965731 DOI: 10.1016/S0076-6879(96)64012-9  0.323
1996 Yasuhira S, Simpson L. Guide RNAs and guide RNA genes in the cryptobiid kinetoplastid protozoan, Trypanoplasma borreli. Rna (New York, N.Y.). 2: 1153-60. PMID 8903345  0.418
1996 Thiemann OH, Simpson L. Analysis of the 3' uridylylation sites of guide RNAs from Leishmania tarentolae Molecular and Biochemical Parasitology. 79: 229-234. PMID 8855560 DOI: 10.1016/0166-6851(96)02653-9  0.429
1996 Frech GC, Simpson L. Uridine insertion into preedited mRNA by a mitochondrial extract from Leishmania tarentolae: Stereochemical evidence for the enzyme cascade model Molecular and Cellular Biology. 16: 4584-4589. PMID 8754859 DOI: 10.1128/Mcb.16.8.4584  0.477
1996 Lima BD, Simpson L. Sequence-dependent in vivo importation of tRNAs into the mitochondrion of Leishmania tarentolae. Rna (New York, N.Y.). 2: 429-40. PMID 8665410  0.328
1995 Bringaud F, Peyruchaud S, Baltz D, Giroud C, Simpson L, Baltz T. Molecular characterization of the mitochondrial heat shock protein 60 gene from Trypanosoma brucei Molecular and Biochemical Parasitology. 74: 119-123. PMID 8719252 DOI: 10.1016/0166-6851(95)02486-7  0.33
1995 Byrne E, Bringaud F, Simpson L. RNA-protein interactions in the ribonucleoprotein T-complexes in a mitochondrial extract from Leishmania tarentolae Molecular and Biochemical Parasitology. 72: 65-76. PMID 8538701 DOI: 10.1016/0166-6851(95)00063-7  0.451
1995 Frech GC, Bakalara N, Simpson L, Simpson AM. In vitro RNA editing-like activity in a mitochondrial extract from Leishmania tarentolae Embo Journal. 14: 178-187. PMID 7828590 DOI: 10.1002/J.1460-2075.1995.Tb06988.X  0.518
1995 Simpson L, Thiemann OH. Sense from nonsense: RNA editing in mitochondria of kinetoplastid protozoa and slime molds Cell. 81: 837-840. PMID 7781060 DOI: 10.1016/0092-8674(95)90003-9  0.478
1995 Bringaud F, Peris M, Zen KH, Simpson L. Characterization of two nuclear-encoded protein components of mitochondrial ribonucleoprotein complexes from Leishmania tarentolae Molecular and Biochemical Parasitology. 71: 65-79. PMID 7630384 DOI: 10.1016/0166-6851(95)00023-T  0.394
1995 Yasuhira S, Simpson L. Minicircle-encoded guide RNAs from Crithidia fasciculata. Rna (New York, N.Y.). 1: 634-43. PMID 7489522  0.413
1995 Maslov DA, Simpson L. Evolution of parasitism in kinetoplastid protozoa Parasitology Today. 11: 30-32. DOI: 10.1016/0169-4758(95)80106-5  0.331
1994 Maslov DA, Avila HA, Lake JA, Simpson L. Evolution of RNA editing in kinetoplastid protozoa Nature. 368: 345-348. PMID 8127370 DOI: 10.1038/368345A0  0.495
1994 Simpson L, Maslov DA. RNA editing and the evolution of parasites Science. 264: 1870-1871. PMID 8009214 DOI: 10.1126/Science.8009214  0.42
1994 Thiemann OH, Maslov DA, Simpson L. Disruption of RNA editing in Leishmania tarentolae by the loss of minicircle-encoded guide RNA genes Embo Journal. 13: 5689-5700. PMID 7988566 DOI: 10.1002/J.1460-2075.1994.Tb06907.X  0.42
1994 Maslov DA, Simpson L. RNA editing and mitochondrial genomic organization in the cryptobiid kinetoplastid protozoan Trypanoplasma borreli Molecular and Cellular Biology. 14: 8174-8182. PMID 7969154 DOI: 10.1128/Mcb.14.12.8174  0.503
1994 Maslov DA, Thiemann O, Simpson L. Editing and misediting of transcripts of the kinetoplast maxicircle G5 (ND3) cryptogene in an old laboratory strain of Leishmania tarentolae Molecular and Biochemical Parasitology. 68: 155-159. PMID 7891741 DOI: 10.1016/0166-6851(94)00160-X  0.476
1994 Simpson L, Maslov DA. Ancient origin of RNA editing in kinetoplastid protozoa Current Opinion in Genetics and Development. 4: 887-894. PMID 7888760 DOI: 10.1016/0959-437X(94)90075-2  0.466
1994 Peris M, Frech GC, Simpson AM, Bringaud F, Byrne E, Bakker A, Simpson L. Characterization of two classes of ribonucleoprotein complexes possibly involved in RNA editing from Leishmania tarentolae mitochondria Embo Journal. 13: 1664-1672. PMID 7512500 DOI: 10.1002/J.1460-2075.1994.Tb06430.X  0.47
1992 von Haeseler A, Blum B, Simpson L, Sturm N, Waterman MS. Computer methods for locating kinetoplastid cryptogenes. Nucleic Acids Research. 20: 2717-24. PMID 1614859 DOI: 10.1093/Nar/20.11.2717  0.372
1992 Blum B, Simpson L. Formation of guide RNA/messenger RNA chimeric molecules in vitro, the initial step of RNA editing, is dependent on an anchor sequence. Proceedings of the National Academy of Sciences of the United States of America. 89: 11944-8. PMID 1465424 DOI: 10.1073/Pnas.89.24.11944  0.497
1992 Sturm NR, Maslov DA, Blum B, Simpson L. Generation of unexpected editing patterns in Leishmania tarentolae mitochondrial mRNAs: misediting produced by misguiding. Cell. 70: 469-76. PMID 1379520 DOI: 10.1016/0092-8674(92)90171-8  0.484
1992 Maslov DA, Simpson L. The polarity of editing within a multiple gRNA-mediated domain is due to formation of anchors for upstream gRNAs by downstream editing Cell. 70: 459-467. PMID 1379519 DOI: 10.1016/0092-8674(92)90170-H  0.362
1992 Maslov DA, Sturm NR, Niner BM, Gruszynski ES, Peris M, Simpson L. An intergenic G-rich region in Leishmania tarentolae kinetoplast maxicircle DNA is a pan-edited cryptogene encoding ribosomal protein S12 Molecular and Cellular Biology. 12: 56-67. PMID 1370342 DOI: 10.1128/Mcb.12.1.56  0.385
1991 Avila H, Goncalves AM, Nehme NS, Morel CM, Simpson L. Schizodeme analysis of Trypanosoma cruzi stocks from South and Central America by analysis of PCR-amplified minicircle variable region sequences. Molecular and Biochemical Parasitology. 42: 175-87. PMID 2270100 DOI: 10.1016/0166-6851(90)90160-N  0.327
1991 Sturm NR, Simpson L. Leishmania tarentolae minicircles of different sequence classes encode single guide RNAs located in the variable region approximately 150 bp from the conserved region. Nucleic Acids Research. 19: 6277-81. PMID 1720240 DOI: 10.1093/Nar/19.22.6277  0.397
1991 Blum B, Sturm NR, Simpson AM, Simpson L. Chimeric gRNA-mRNA molecules with oligo(U) tails covalently linked at sites of RNA editing suggest that U addition occurs by transesterification. Cell. 65: 543-50. PMID 1709591 DOI: 10.1016/0092-8674(91)90087-F  0.482
1990 Campbell DA, Suyama Y, Simpson L. Genomic organisation of nuclear tRNAGly and tRNALeu genes in Trypanosoma brucei. Molecular and Biochemical Parasitology. 37: 257-62. PMID 2608100 DOI: 10.1016/0166-6851(89)90157-6  0.413
1990 Sturm NR, Simpson L. Partially edited mRNAs for cytochrome b and subunit III of cytochrome oxidase from Leishmania tarentolae mitochondria: RNA editing intermediates. Cell. 61: 871-8. PMID 2160860 DOI: 10.1016/0092-8674(90)90197-M  0.495
1990 Simpson L. RNA editing - A novel genetic phenomenon? Science. 250: 512-513. PMID 1700474 DOI: 10.1126/Science.1700474  0.389
1990 Blum B, Simpson L. Guide RNAs in kinetoplastid mitochondria have a nonencoded 3' oligo(U) tail involved in recognition of the preedited region. Cell. 62: 391-7. PMID 1695552 DOI: 10.1016/0092-8674(90)90375-O  0.488
1990 Sturm NR, Simpson L. Kinetoplast DNA minicircles encode guide RNAs for editing of cytochrome oxidase subunit III mRNA. Cell. 61: 879-84. PMID 1693097 DOI: 10.1016/0092-8674(90)90198-N  0.448
1990 Blum B, Bakalara N, Simpson L. A model for RNA editing in kinetoplastid mitochondria: "guide" RNA molecules transcribed from maxicircle DNA provide the edited information. Cell. 60: 189-98. PMID 1688737 DOI: 10.1016/0092-8674(90)90735-W  0.502
1989 Campbell DA, Spithill TW, Samaras N, Simpson AM, Simpson L. Sequence of a cDNA for the ND1 gene from Leishmania major: potential uridine addition in the polyadenosine tail Molecular and Biochemical Parasitology. 36: 197-199. PMID 2770790 DOI: 10.1016/0166-6851(89)90192-8  0.513
1989 Simpson AM, Suyama Y, Dewcs H, Campbell DA, Simpson L. Kinetoplastid mitochondria contain functional tRNAs which are encoded in nuclear DNA and also contain small mlnltircje and maxicircle transcripts of unknown function Nucleic Acids Research. 17: 5427-5446. PMID 2762144 DOI: 10.1093/Nar/17.14.5427  0.514
1989 Sturm NR, Degrave W, Morel C, Simpson L. Sensitive detection and schizodeme classification of Trypanosoma cruzi cells by amplification of kinetoplast minicircle DNA sequences: use in diagnosis of Chagas' disease. Molecular and Biochemical Parasitology. 33: 205-14. PMID 2565018 DOI: 10.1016/0166-6851(89)90082-0  0.313
1989 Shaw JM, Campbell D, Simpson L. Internal frameshifts within the mitochondrial genes for cytochrome oxidase subunit II and maxicircle unidentified reading frame 3 of Leishmania tarentolae are corrected by RNA editing: evidence for translation of the edited cytochrome oxidase subunit II mRNA. Proceedings of the National Academy of Sciences of the United States of America. 86: 6220-4. PMID 2548203 DOI: 10.1073/Pnas.86.16.6220  0.64
1989 Shaw JM, Simpson L. Characterization of a protein fraction containing cytochromes b and c1 from mitochondria of Leishmania tarentolae. Experimental Parasitology. 68: 443-9. PMID 2542079 DOI: 10.1016/0014-4894(89)90129-X  0.489
1989 Hughes DE, Shonekan OA, Simpson L. Structure, genomic organization and transcription of the bifunctional dihydrofolate reductase-thymidylate synthase gene from Crithidia fasciculata. Molecular and Biochemical Parasitology. 34: 155-66. PMID 2540436 DOI: 10.1016/0166-6851(89)90007-8  0.402
1989 Simpson L, Shaw J. RNA editing and the mitochondrial cryptogenes of kinetoplastid protozoa. Cell. 57: 355-66. PMID 2470509 DOI: 10.1016/0092-8674(89)90911-2  0.579
1988 Simpson L, Shaw J, Campbell D, Bakalara N. RNA editing--a novel RNA processing phenomenon in trypanosome mitochondria. MemóRias Do Instituto Oswaldo Cruz. 83: 243. PMID 3253498 DOI: 10.1590/S0074-02761988000500003  0.61
1988 Lake JA, de la Cruz VF, Ferreira PC, Morel C, Simpson L. Evolution of parasitism: kinetoplastid protozoan history reconstructed from mitochondrial rRNA gene sequences. Proceedings of the National Academy of Sciences of the United States of America. 85: 4779-83. PMID 3133662 DOI: 10.1073/Pnas.85.13.4779  0.333
1988 Degrave W, Fragoso SP, Britto C, van Heuverswyn H, Kidane GZ, Cardoso MA, Mueller RU, Simpson L, Morel CM. Peculiar sequence organization of kinetoplast DNA minicircles from Trypanosoma cruzi. Molecular and Biochemical Parasitology. 27: 63-70. PMID 2830509 DOI: 10.1016/0166-6851(88)90025-4  0.33
1988 Shaw JM, Feagin JE, Stuart K, Simpson L. Editing of kinetoplastid mitochondrial mRNAs by uridine addition and deletion generates conserved amino acid sequences and AUG initiation codons. Cell. 53: 401-11. PMID 2452696 DOI: 10.1016/0092-8674(88)90160-2  0.629
1988 Feagin JE, Shaw JM, Simpson L, Stuart K. Creation of AUG initiation codons by addition of uridines within cytochrome b transcripts of kinetoplastids. Proceedings of the National Academy of Sciences of the United States of America. 85: 539-43. PMID 2448777 DOI: 10.1073/Pnas.85.2.539  0.494
1987 Muhich ML, Hughes DE, Simpson AM, Simpson L. The monogenetic kinetoplastid protozoan, Crithidia fasciculate, contains a transcriptionally active, multicopy mini-exon sequence Nucleic Acids Research. 15: 3141-3153. PMID 3562248 DOI: 10.1093/Nar/15.7.3141  0.384
1987 Simpson L. The mitochondrial genome of kinetoplastid protozoa: genomic organization, transcription, replication, and evolution Annual Review of Microbiology. 41: 363-382. PMID 2825587 DOI: 10.1146/Annurev.Mi.41.100187.002051  0.401
1986 Simpson L. Kinetoplast DNA in trypanosomid flagellates International Review of Cytology. 119-179. PMID 3082787 DOI: 10.1016/S0074-7696(08)61426-6  0.339
1986 Hughes DE, Simpson L. Introduction of plasmid DNA into the trypanosomatid protozoan Crithidia fasciculata. Proceedings of the National Academy of Sciences of the United States of America. 83: 6058-62. PMID 3016740 DOI: 10.1073/Pnas.83.16.6058  0.326
1986 Muhich ML, Simpson L. Specific cleavage of kinetoplast minicircle DNA from Leishmania tarentolae by mung bean nuclease and identification of several additional minicircle sequence classes Nucleic Acids Research. 14: 5531-5556. PMID 3016649 DOI: 10.1093/Nar/14.13.5531  0.332
1985 Hughes D, Simpson L, Kayne PS, Neckelmann N. Autonomous replication sequences in the maxicircle kinetoplast DNA of Leishmania tarentolae. Molecular and Biochemical Parasitology. 13: 263-75. PMID 6396515 DOI: 10.1016/0166-6851(84)90118-X  0.353
1985 De la Cruz VF, Lake JA, Simpson AM, Simpson L. A minimal ribosomal RNA: Sequence and secondary structure of the 9S kinetoplast ribosomal RNA from Leishmania tarentolae Proceedings of the National Academy of Sciences of the United States of America. 82: 1401-1405. PMID 3856267 DOI: 10.1073/Pnas.82.5.1401  0.477
1985 Simpson AM, Neckelmann N, de la Cruz VF, Muhich ML, Simpson L. Mapping and 5′ end determination of kinetoplast maxicircle gene transcripts from Leishmania tarentolae Nucleic Acids Research. 13: 5977-5993. PMID 2994021 DOI: 10.1093/Nar/13.16.5977  0.465
1985 Muhich ML, Neckelmann N, Simpson L. The divergent region of the Leishmania tarentolae kinetoplast maxicircle DNA contains a diverse set of repetitive sequences. Nucleic Acids Research. 13: 3241-60. PMID 2987878 DOI: 10.1093/Nar/13.9.3241  0.318
1985 de la Cruz VF, Simpson AM, Lake JA, Simpson L. Primary sequence and partial secondary structure of the 12S kinetoplast (mitochondrial) ribosomal RNA from Leishmania tarentolae: Conservation of peptidyl-transferase structural elements Nucleic Acids Research. 13: 2337-2356. PMID 2987850 DOI: 10.1093/Nar/13.7.2337  0.458
1984 Kidane GZ, Hughes D, Simpson L. Sequence heterogeneity and anomalous electrophoretic mobility of kinetoplast minicircle DNA from Leishmania tarentolae. Gene. 27: 265-77. PMID 6329906 DOI: 10.1016/0378-1119(84)90071-4  0.326
1983 Muhich ML, Simpson L, Simpson AM. Comparison of maxicircle DNAs of Leishmania tarentolae and Trypanosoma brucei Proceedings of the National Academy of Sciences of the United States of America. 80: 4060-4064. PMID 6306661 DOI: 10.1073/Pnas.80.13.4060  0.341
1982 Simpson L, Spithill TW, Simpson AM. Identification of maxicircle DNA sequences in Leishmania tarentolae that are homologous to sequences of specific yeast mitochondrial structural genes Molecular and Biochemical Parasitology. 6: 253-264. PMID 6292714 DOI: 10.1016/0166-6851(82)90058-5  0.444
1982 Simpson AM, Simpson L, Livingston L. Transcription of the maxicircle kinetoplast DNA of Leishmania tarentolae Molecular and Biochemical Parasitology. 6: 237-252. PMID 6183585 DOI: 10.1016/0166-6851(82)90057-3  0.416
1982 Simpson L, Simpson AM, Spithill TW, Livingston L. Sequence Organization of Maxicircle Kinetoplast DNA from Leishmania tarentolae Cold Spring Harbor Monograph Archive. 12: 435-439. DOI: 10.1101/087969145.12.435  0.498
1981 Morel C, Simpson L. Characterization of pathogenic trypanosomatidae by restriction endonuclease fingerprinting of kinetoplast DNA minicircles. The American Journal of Tropical Medicine and Hygiene. 29: 1070-4. PMID 6254386 DOI: 10.4269/Ajtmh.1980.29.1070  0.3
1980 Simpson AM, Simpson L. Kinetoplast DNA and RNA of Trypanosoma brucei Molecular and Biochemical Parasitology. 2: 93-108. PMID 6162099 DOI: 10.1016/0166-6851(80)90034-1  0.448
1980 Simpson L, Simpson AM, Kidane G, Livingston L, Spithill TW. The kinetoplast DNA of the hemoflagellate protozoa. The American Journal of Tropical Medicine and Hygiene. 29: 1053-63. PMID 6159799 DOI: 10.4269/Ajtmh.1980.29.1053  0.475
1979 Masuda H, Simpson L, Rosenblatt H, Simpson AM. Restriction map, partial cloning and localization of 9S and 12S kinetoplast RNA genes on the maxicircle component of the kinetoplast DNA of Leishmania tarentolae Gene. 6: 51-73. PMID 383578 DOI: 10.1016/0378-1119(79)90085-4  0.418
1978 Cheng D, Simpson L. Isolation and characterization of kinetoplast DNA and RNA of Phytomonas davidi. Plasmid. 1: 297-315. PMID 748951 DOI: 10.1016/0147-619X(78)90047-1  0.359
1978 Simpson L, Simpson AM. Kinetoplast RNA of Leishmania tarentolae Cell. 14: 169-178. PMID 667932 DOI: 10.1016/0092-8674(78)90311-2  0.506
1975 Braly P, Simpson L, Kretzer F. Isolation of kinetoplast-mitochondrial complexes from Leishmania tarentolae. The Journal of Protozoology. 21: 782-90. PMID 4217377 DOI: 10.1111/J.1550-7408.1974.Tb03752.X  0.374
1973 Wesley RD, Simpson L. Studies on kinetoplast DNA III. Kinetic complexity of kinetoplast and nuclear DNA from Leishmania tarentolae Biochimica Et Biophysica Acta. 319: 267-276. PMID 4747081 DOI: 10.1016/0005-2787(73)90165-2  0.303
1972 Simpson L. The Kinetoplast of the Hernoflagellates International Review of Cytology. 32: 139-207. DOI: 10.1016/S0074-7696(08)60340-X  0.35
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