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Brad S. Rothberg, Ph.D. - Publications

Affiliations: 
Biochemistry Temple University, Philadelphia, PA, United States 
Area:
K+ channels
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68 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Kopec W, Thomson AS, de Groot BL, Rothberg BS. Interactions between selectivity filter and pore helix control filter gating in the MthK channel. The Journal of General Physiology. 155. PMID 37318452 DOI: 10.1085/jgp.202213166  0.598
2022 Rothberg BS. Interrogating the gating motions of the NaK channel. The Journal of General Physiology. 154. PMID 36326621 DOI: 10.1085/jgp.202213257  0.404
2021 Vouga AG, Rockman ME, Yan J, Jacobson MA, Rothberg BS. State-dependent inhibition of BK channels by the opioid agonist loperamide. The Journal of General Physiology. 153. PMID 34357374 DOI: 10.1085/jgp.202012834  0.853
2020 Brauchi SE, Rothberg BS. Gating and calcium-sensing mechanisms of TRPA1 channels revealed. Cell Calcium. 91: 102278. PMID 32858446 DOI: 10.1016/J.Ceca.2020.102278  0.61
2020 Suma A, Granata D, Thomson AS, Carnevale V, Rothberg BS. Polyamine blockade and binding energetics in the MthK potassium channel. The Journal of General Physiology. 152. PMID 32342093 DOI: 10.1085/Jgp.201912527  0.645
2020 Rockman ME, Vouga AG, Rothberg BS. Molecular mechanism of BK channel activation by the smooth muscle relaxant NS11021. The Journal of General Physiology. 152. PMID 32221543 DOI: 10.1085/Jgp.201912506  0.86
2019 Kopec W, Rothberg BS, de Groot BL. Molecular mechanism of a potassium channel gating through activation gate-selectivity filter coupling. Nature Communications. 10: 5366. PMID 31772184 DOI: 10.1038/S41467-019-13227-W  0.542
2019 Vouga AG, Matychak KK, Rockman ME, Flores L, Brauchi S, Rothberg BS. Multiple Nucleotide-Dependent Conformations of a Mycobacterial RCK Domain Biophysical Journal. 116: 109a. DOI: 10.1016/J.Bpj.2018.11.621  0.757
2019 Vouga AG, Rockman ME, Jacobson MA, Rothberg BS. Mechanism of BK Channel Inhibition by the Opioid Agonist Loperamide Biophysical Journal. 116: 543a. DOI: 10.1016/J.Bpj.2018.11.2919  0.806
2019 Bonanno AP, Vouga AG, Rothberg BS, Chong PL. MthK Channel Activity in Planar Tetraether Lipid Membranes Biophysical Journal. 116: 364a-365a. DOI: 10.1016/J.Bpj.2018.11.1983  0.429
2018 Rothberg BS. Charge of the Proton Channel. Biophysical Journal. 114: 2759-2761. PMID 29925012 DOI: 10.1016/J.Bpj.2018.05.008  0.46
2018 Li Q, Li Y, Wei H, Pan HM, Vouga AG, Rothberg BS, Wu Y, Yan J. Molecular determinants of Ca2+ sensitivity at the intersubunit interface of the BK channel gating ring. Scientific Reports. 8: 509. PMID 29323236 DOI: 10.1038/S41598-017-19029-8  0.593
2018 Vouga AG, Matychak KK, Rockman ME, Garcia S, Brauchi S, Rothberg BS. Crystal Structure of a Mycobacterial RCK Domain Biophysical Journal. 114: 127a. DOI: 10.1016/J.Bpj.2017.11.723  0.745
2017 Giraldez T, Rothberg BS. Understanding the conformational motions of RCK gating rings. The Journal of General Physiology. PMID 28246116 DOI: 10.1085/Jgp.201611726  0.592
2017 Vouga AG, Rothberg B. Role of an Intersubunit Ca 2+ Bridge in BK Channel Gating Biophysical Journal. 112: 253a. DOI: 10.1016/J.Bpj.2016.11.1379  0.609
2016 Zhou Y, Cai X, Loktionova NA, Wang X, Nwokonko RM, Wang X, Wang Y, Rothberg BS, Trebak M, Gill DL. The STIM1-binding site nexus remotely controls Orai1 channel gating. Nature Communications. 7: 13725. PMID 27929067 DOI: 10.1038/Ncomms13725  0.616
2016 Hooper R, Rothberg BS, Soboloff J. Sterol hindrance of Orai activation. Science Signaling. 9: fs4. PMID 26956482 DOI: 10.1126/Scisignal.Aaf2357  0.536
2016 Pau VP, Abarca-Heidemann K, Hendron E, Stezzi M, Cingolani G, Rothberg BS. Crystal Structure and Asymmetric Conformation of a K+ Channel RCK Domain Biophysical Journal. 110: 291a. DOI: 10.1016/J.Bpj.2015.11.1575  0.823
2016 Vouga AG, Hendron E, Rothberg BS. Role of an Intersubunit Ca2+ Bridge in Structure and Function of BK Channels Biophysical Journal. 110: 187a. DOI: 10.1016/J.Bpj.2015.11.1042  0.865
2015 Zhou Y, Wang X, Wang X, Loktionova NA, Cai X, Nwokonko RM, Vrana E, Wang Y, Rothberg BS, Gill DL. STIM1 dimers undergo unimolecular coupling to activate Orai1 channels. Nature Communications. 6: 8395. PMID 26399906 DOI: 10.1038/Ncomms9395  0.602
2015 Rothberg B. Conformational Motions of K+ Channel RCK Domains Biophysical Journal. 108: 9a. DOI: 10.1016/J.Bpj.2014.11.070  0.651
2014 McManus OB, Rothberg BS. An old probe sheds new light on BK channel pore structure. The Journal of General Physiology. 144: 499-501. PMID 25385785 DOI: 10.1085/Jgp.201411306  0.436
2014 Hooper R, Rothberg BS, Soboloff J. Neuronal STIMulation at rest. Science Signaling. 7: pe18. PMID 25056876 DOI: 10.1126/Scisignal.2005556  0.404
2014 Thomson AS, Heer FT, Smith FJ, Hendron E, Bernèche S, Rothberg BS. Initial steps of inactivation at the K+ channel selectivity filter. Proceedings of the National Academy of Sciences of the United States of America. 111: E1713-22. PMID 24733889 DOI: 10.1073/Pnas.1317573111  0.838
2014 Wang X, Wang Y, Zhou Y, Hendron E, Mancarella S, Andrake MD, Rothberg BS, Soboloff J, Gill DL. Distinct Orai-coupling domains in STIM1 and STIM2 define the Orai-activating site. Nature Communications. 5: 3183. PMID 24492416 DOI: 10.1038/Ncomms4183  0.837
2014 Heer FT, Thomson AS, Rothberg BS, Berneèche S. Microscopic Mechanisms Underlying Inactivation in the KcsA and MTHK K+ Channels Biophysical Journal. 106: 542a. DOI: 10.1016/J.Bpj.2013.11.3021  0.672
2013 Smith FJ, Pau VP, Cingolani G, Rothberg BS. Structural basis of allosteric interactions among Ca2+-binding sites in a K+ channel RCK domain. Nature Communications. 4: 2621. PMID 24126388 DOI: 10.1038/Ncomms3621  0.868
2013 Abarca-Heidemann K, Duchardt-Ferner E, Woehnert J, Rothberg BS. Isotope labeling strategies for analysis of an ion channel cytoplasmic domain by NMR spectroscopy. Methods in Molecular Biology (Clifton, N.J.). 998: 289-300. PMID 23529439 DOI: 10.1007/978-1-62703-351-0_23  0.834
2013 Smith FJ, Rothberg BS. Analysis of Ca(2+)-binding sites in the MthK RCK domain by X-ray crystallography. Methods in Molecular Biology (Clifton, N.J.). 998: 277-87. PMID 23529438 DOI: 10.1007/978-1-62703-351-0_22  0.748
2013 Rothberg BS, Wang Y, Gill DL. Orai channel pore properties and gating by STIM: implications from the Orai crystal structure. Science Signaling. 6: pe9. PMID 23512988 DOI: 10.1126/Scisignal.2003971  0.615
2013 Thomson AS, Heer F, Berneche S, Rothberg BS. Mechanisms of Fast Blockade and Gating of the MthK Channel Pore by Divalent Cations Biophysical Journal. 104: 122a. DOI: 10.1016/J.Bpj.2012.11.706  0.697
2013 Smith FJ, Rothberg BS. Crystal Structures of the MthK RCK Domain Reveal Allosteric Interactions Among Calcium Binding Sites Biophysical Journal. 104: 367a. DOI: 10.1016/J.Bpj.2012.11.2038  0.752
2012 Mallilankaraman K, Doonan P, Cárdenas C, Chandramoorthy HC, Müller M, Miller R, Hoffman NE, Gandhirajan RK, Molgó J, Birnbaum MJ, Rothberg BS, Mak DO, Foskett JK, Madesh M. MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survival. Cell. 151: 630-44. PMID 23101630 DOI: 10.1016/J.Cell.2012.10.011  0.428
2012 Smith FJ, Pau VP, Cingolani G, Rothberg BS. Crystal structure of a Ba(2+)-bound gating ring reveals elementary steps in RCK domain activation. Structure (London, England : 1993). 20: 2038-47. PMID 23085076 DOI: 10.1016/J.Str.2012.09.014  0.874
2012 Rothberg BS. The BK channel: a vital link between cellular calcium and electrical signaling. Protein & Cell. 3: 883-92. PMID 22996175 DOI: 10.1007/S13238-012-2076-8  0.611
2012 Soboloff J, Rothberg BS, Madesh M, Gill DL. STIM proteins: dynamic calcium signal transducers. Nature Reviews. Molecular Cell Biology. 13: 549-65. PMID 22914293 DOI: 10.1038/Nrm3414  0.426
2012 Smith FJ, Pau VP, Taylor AB, Parfenova LV, Samakai E, Callaghan MM, Abarca-Heidemann K, Hart PJ, Rothberg BS. Multiple Ca2+ Binding Sites in the RCK Domain Contribute to Gating in the MthK K+ Channel Biophysical Journal. 102: 690a. DOI: 10.1016/J.Bpj.2011.11.3746  0.839
2012 Thomson AS, Rothberg BS. Inhibition of MthK K+ Channels by Mg2+ and Polyamines: Inward Rectification with a Short Pore Biophysical Journal. 102: 537a. DOI: 10.1016/J.Bpj.2011.11.2934  0.686
2011 Pau VP, Smith FJ, Taylor AB, Parfenova LV, Samakai E, Callaghan MM, Abarca-Heidemann K, Hart PJ, Rothberg BS. Structure and function of multiple Ca2+-binding sites in a K+ channel regulator of K+ conductance (RCK) domain. Proceedings of the National Academy of Sciences of the United States of America. 108: 17684-9. PMID 21997217 DOI: 10.1073/Pnas.1107229108  0.846
2011 Pau VP, Rothberg BS. Molecular Determinants of Ca2+ Binding in the Mthk K+ Channel Biophysical Journal. 100: 260a. DOI: 10.1016/J.Bpj.2010.12.1635  0.864
2010 Thomson AS, Rothberg BS. Voltage-dependent inactivation gating at the selectivity filter of the MthK K+ channel. The Journal of General Physiology. 136: 569-79. PMID 20937694 DOI: 10.1016/J.Bpj.2010.12.3364  0.67
2010 Pau VP, Abarca-Heidemann K, Rothberg BS. Allosteric mechanism of Ca2+ activation and H+-inhibited gating of the MthK K+ channel. The Journal of General Physiology. 135: 509-26. PMID 20421375 DOI: 10.1085/Jgp.200910387  0.833
2010 Abarca-Heidemann K, Woehnert J, Rothberg BS. Identification of Divalent Cation Coordinating Residues in a K+ Channel RCK Domain by NMR Spectroscopy Biophysical Journal. 98: 127a. DOI: 10.1016/J.Bpj.2009.12.687  0.83
2010 Pau VP, Abarca-Heidemann K, Rothberg BS. Mechanism Underlying pH-Modulation of Ca2+-Dependent Gating in the MthK Channel Biophysical Journal. 98: 126a-127a. DOI: 10.1016/J.Bpj.2009.12.686  0.83
2009 Semenova NP, Abarca-Heidemann K, Loranc E, Rothberg BS. Bimane fluorescence scanning suggests secondary structure near the S3-S4 linker of BK channels. The Journal of Biological Chemistry. 284: 10684-93. PMID 19244238 DOI: 10.1074/Jbc.M808891200  0.836
2009 Wang B, Rothberg BS, Brenner R. Mechanism of increased BK channel activation from a channel mutation that causes epilepsy. The Journal of General Physiology. 133: 283-94. PMID 19204188 DOI: 10.1085/Jgp.200810141  0.512
2008 Rothberg BS. Return of the electric binding site. The Journal of General Physiology. 132: 487-9. PMID 18955591 DOI: 10.1085/Jgp.200810135  0.611
2007 Parfenova LV, Abarca-Heidemann K, Crane BM, Rothberg BS. Molecular architecture and divalent cation activation of TvoK, a prokaryotic potassium channel. The Journal of Biological Chemistry. 282: 24302-9. PMID 17588939 DOI: 10.1074/Jbc.M703650200  0.866
2007 Koval OM, Fan Y, Rothberg BS. A role for the S0 transmembrane segment in voltage-dependent gating of BK channels. The Journal of General Physiology. 129: 209-20. PMID 17296928 DOI: 10.1085/Jgp.200609662  0.791
2006 Parfenova LV, Rothberg BS. Genetic screening for functionality of bacterial potassium channel mutants using K+ uptake-deficient Escherichia coli. Methods in Molecular Biology (Clifton, N.J.). 337: 157-65. PMID 16929946 DOI: 10.1385/1-59745-095-2:157  0.798
2006 Parfenova LV, Crane BM, Rothberg BS. Modulation of MthK potassium channel activity at the intracellular entrance to the pore. The Journal of Biological Chemistry. 281: 21131-8. PMID 16728395 DOI: 10.1074/Jbc.M603109200  0.832
2006 Wang B, Rothberg BS, Brenner R. Mechanism of beta4 subunit modulation of BK channels. The Journal of General Physiology. 127: 449-65. PMID 16567466 DOI: 10.1085/Jgp.200509436  0.523
2004 Rothberg BS. Allosteric modulation of ion channels: the case of maxi-K. Science's Stke : Signal Transduction Knowledge Environment. 2004: pe16. PMID 15069208 DOI: 10.1126/Stke.2272004Pe16  0.6
2004 Shin KS, Maertens C, Proenza C, Rothberg BS, Yellen G. Inactivation in HCN channels results from reclosure of the activation gate: desensitization to voltage. Neuron. 41: 737-44. PMID 15003173 DOI: 10.1016/S0896-6273(04)00083-2  0.839
2003 Rothberg BS, Shin KS, Yellen G. Movements near the gate of a hyperpolarization-activated cation channel. The Journal of General Physiology. 122: 501-10. PMID 14557404 DOI: 10.1085/Jgp.200308928  0.763
2002 Rothberg BS, Shin KS, Phale PS, Yellen G. Voltage-controlled gating at the intracellular entrance to a hyperpolarization-activated cation channel. The Journal of General Physiology. 119: 83-91. PMID 11773240 DOI: 10.1085/Jgp.119.1.83  0.791
2001 Rothberg BS, Magleby KL. Testing for detailed balance (microscopic reversibility in ion channel gating. Biophysical Journal. 80: 3025-6. PMID 11432375 DOI: 10.1016/S0006-3495(01)76268-6  0.712
2001 Shin KS, Rothberg BS, Yellen G. Blocker state dependence and trapping in hyperpolarization-activated cation channels: evidence for an intracellular activation gate. The Journal of General Physiology. 117: 91-101. PMID 11158163 DOI: 10.1085/Jgp.117.2.91  0.797
2000 Rothberg BS, Magleby KL. Voltage and Ca2+ activation of single large-conductance Ca2+-activated K+ channels described by a two-tiered allosteric gating mechanism. The Journal of General Physiology. 116: 75-99. PMID 10871641 DOI: 10.1085/Jgp.116.1.75  0.74
1999 Rothberg BS, Magleby KL. Gating kinetics of single large-conductance Ca2+-activated K+ channels in high Ca2+ suggest a two-tiered allosteric gating mechanism. The Journal of General Physiology. 114: 93-124. PMID 10398695 DOI: 10.1085/Jgp.114.1.93  0.747
1998 Rothberg BS, Magleby KL. Investigating single-channel gating mechanisms through analysis of two-dimensional dwell-time distributions. Methods in Enzymology. 293: 437-56. PMID 9711623 DOI: 10.1016/S0076-6879(98)93028-2  0.708
1998 Rothberg BS, Magleby KL. Kinetic structure of large-conductance Ca2+-activated K+ channels suggests that the gating includes transitions through intermediate or secondary states. A mechanism for flickers. The Journal of General Physiology. 111: 751-80. PMID 9607935 DOI: 10.1085/Jgp.111.6.751  0.771
1997 Rothberg BS, Bello RA, Magleby KL. Two-dimensional components and hidden dependencies provide insight into ion channel gating mechanisms. Biophysical Journal. 72: 2524-44. PMID 9168029 DOI: 10.1016/S0006-3495(97)78897-0  0.653
1996 Rothberg BS, Hunter BE, Walker DW, Anderson JF, Anderson KJ. Long-term effects of chronic ethanol on muscarinic receptor binding in rat brain. Alcoholism, Clinical and Experimental Research. 20: 1613-7. PMID 8986212 DOI: 10.1111/J.1530-0277.1996.Tb01706.X  0.645
1996 Rothberg BS, Bello RA, Song L, Magleby KL. High Ca2+ concentrations induce a low activity mode and reveal Ca2(+)-independent long shut intervals in BK channels from rat muscle. The Journal of Physiology. 493: 673-89. PMID 8799891 DOI: 10.1113/Jphysiol.1996.Sp021414  0.718
1996 Rothberg BS, Bello RA, Song L, Magleby KL. High Ca2+ concentrations induce a low activity mode and reveal Ca2+-independent long shut intervals in BK channels from rat muscle Journal of Physiology. 493: 673-689.  0.676
1993 Rothberg BS, Yasuda RP, Satkus SA, Wolfe BB, Hunter BE. Effects of chronic ethanol on cholinergic actions in rat hippocampus: electrophysiological studies and quantification of m1-m5 muscarinic receptor subtypes. Brain Research. 631: 227-34. PMID 8131051 DOI: 10.1016/0006-8993(93)91539-5  0.639
1991 Rothberg BS, Hunter BE. Chronic ethanol treatment differentially affects muscarinic receptor responses in rat hippocampus. Neuroscience Letters. 132: 243-6. PMID 1784427 DOI: 10.1016/0304-3940(91)90311-G  0.64
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