Manuela Polydoro, Ph.D. - Publications

Neurology MGH-Harvard 
Alzheimer's disease

26 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Holtzman DM, Carrillo MC, Hendrix JA, Bain LJ, Catafau AM, Gault LM, Goedert M, Mandelkow E, Mandelkow EM, Miller DS, Ostrowitzki S, Polydoro M, Smith S, Wittmann M, Hutton M. Tau: From research to clinical development. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 27154059 DOI: 10.1016/j.jalz.2016.03.018  0.64
2015 Pooler AM, Polydoro M, Maury EA, Nicholls SB, Reddy SM, Wegmann S, William C, Saqran L, Cagsal-Getkin O, Pitstick R, Beier DR, Carlson GA, Spires-Jones TL, Hyman BT. Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer's disease. Acta Neuropathologica Communications. 3: 14. PMID 25853174 DOI: 10.1186/s40478-015-0199-x  0.64
2015 Saidi LJ, Polydoro M, Kay KR, Sanchez L, Mandelkow EM, Hyman BT, Spires-Jones TL. Carboxy terminus heat shock protein 70 interacting protein reduces tau-associated degenerative changes. Journal of Alzheimer's Disease : Jad. 44: 937-47. PMID 25374103 DOI: 10.3233/JAD-142094  0.64
2014 Spires-Jones TL, Friedman T, Pitstick R, Polydoro M, Roe A, Carlson GA, Hyman BT. Methylene blue does not reverse existing neurofibrillary tangle pathology in the rTg4510 mouse model of tauopathy. Neuroscience Letters. 562: 63-8. PMID 24462887 DOI: 10.1016/j.neulet.2014.01.013  0.64
2014 Polydoro M, Dzhala VI, Pooler AM, Nicholls SB, McKinney AP, Sanchez L, Pitstick R, Carlson GA, Staley KJ, Spires-Jones TL, Hyman BT. Soluble pathological tau in the entorhinal cortex leads to presynaptic deficits in an early Alzheimer's disease model. Acta Neuropathologica. 127: 257-70. PMID 24271788 DOI: 10.1007/s00401-013-1215-5  0.64
2014 Ren Y, Lin WL, Sanchez L, Ceballos C, Polydoro M, Spires-Jones TL, Hyman BT, Dickson DW, Sahara N. Endogenous tau aggregates in oligodendrocytes of rTg4510 mice induced by human P301L tau. Journal of Alzheimer's Disease : Jad. 38: 589-600. PMID 24028867 DOI: 10.3233/JAD-130986  0.64
2013 Pooler AM, Polydoro M, Wegmann S, Nicholls SB, Spires-Jones TL, Hyman BT. Propagation of tau pathology in Alzheimer's disease: identification of novel therapeutic targets. Alzheimer's Research & Therapy. 5: 49. PMID 24152385 DOI: 10.1186/alzrt214  0.64
2013 Polydoro M, de Calignon A, Suárez-Calvet M, Sanchez L, Kay KR, Nicholls SB, Roe AD, Pitstick R, Carlson GA, Gómez-Isla T, Spires-Jones TL, Hyman BT. Reversal of neurofibrillary tangles and tau-associated phenotype in the rTgTauEC model of early Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 13300-11. PMID 23946388 DOI: 10.1523/JNEUROSCI.0881-13.2013  0.64
2013 Pooler AM, Polydoro M, Wegmann SK, Pitstick R, Kay KR, Sanchez L, Carlson GA, Gomez-Isla T, Albers MW, Spires-Jones TL, Hyman BT. Tau-amyloid interactions in the rTgTauEC model of early Alzheimer's disease suggest amyloid-induced disruption of axonal projections and exacerbated axonal pathology. The Journal of Comparative Neurology. 521: 4236-48. PMID 23839581 DOI: 10.1002/cne.23411  0.64
2013 Crimins JL, Pooler A, Polydoro M, Luebke JI, Spires-Jones TL. The intersection of amyloid β and tau in glutamatergic synaptic dysfunction and collapse in Alzheimer's disease. Ageing Research Reviews. 12: 757-63. PMID 23528367 DOI: 10.1016/j.arr.2013.03.002  0.64
2013 Kopeikina KJ, Polydoro M, Tai HC, Yaeger E, Carlson GA, Pitstick R, Hyman BT, Spires-Jones TL. Synaptic alterations in the rTg4510 mouse model of tauopathy. The Journal of Comparative Neurology. 521: 1334-53. PMID 23047530 DOI: 10.1002/cne.23234  0.64
2012 de Calignon A, Polydoro M, Suárez-Calvet M, William C, Adamowicz DH, Kopeikina KJ, Pitstick R, Sahara N, Ashe KH, Carlson GA, Spires-Jones TL, Hyman BT. Propagation of tau pathology in a model of early Alzheimer's disease. Neuron. 73: 685-97. PMID 22365544 DOI: 10.1016/j.neuron.2011.11.033  0.64
2012 Ofengeim D, Shi P, Miao B, Fan J, Xia X, Fan Y, Lipinski MM, Hashimoto T, Polydoro M, Yuan J, Wong ST, Degterev A. Identification of small molecule inhibitors of neurite loss induced by Aβ peptide using high content screening. The Journal of Biological Chemistry. 287: 8714-23. PMID 22277654 DOI: 10.1074/jbc.M111.290957  0.64
2010 Greten-Harrison B, Polydoro M, Morimoto-Tomita M, Diao L, Williams AM, Nie EH, Makani S, Tian N, Castillo PE, Buchman VL, Chandra SS. αβγ-Synuclein triple knockout mice reveal age-dependent neuronal dysfunction. Proceedings of the National Academy of Sciences of the United States of America. 107: 19573-8. PMID 20974939 DOI: 10.1073/pnas.1005005107  0.64
2009 Polydoro M, Acker CM, Duff K, Castillo PE, Davies P. Age-dependent impairment of cognitive and synaptic function in the htau mouse model of tau pathology. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 10741-9. PMID 19710325 DOI: 10.1523/JNEUROSCI.1065-09.2009  0.64
2007 Budni P, de Lima MN, Polydoro M, Moreira JC, Schroder N, Dal-Pizzol F. Antioxidant effects of selegiline in oxidative stress induced by iron neonatal treatment in rats. Neurochemical Research. 32: 965-72. PMID 17401681 DOI: 10.1007/s11064-006-9249-x  0.64
2006 Bonatto F, Polydoro M, Andrades ME, Conte da Frota ML, Dal-Pizzol F, Rotta LN, Souza DO, Perry ML, Fonseca Moreira JC. Effects of maternal protein malnutrition on oxidative markers in the young rat cortex and cerebellum. Neuroscience Letters. 406: 281-4. PMID 16930840 DOI: 10.1016/j.neulet.2006.07.052  0.64
2006 Blanchard-Fillion B, Prou D, Polydoro M, Spielberg D, Tsika E, Wang Z, Hazen SL, Koval M, Przedborski S, Ischiropoulos H. Metabolism of 3-nitrotyrosine induces apoptotic death in dopaminergic cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 6124-30. PMID 16763020 DOI: 10.1523/JNEUROSCI.1038-06.2006  0.64
2006 Heijnen HF, van Donselaar E, Slot JW, Fries DM, Blachard-Fillion B, Hodara R, Lightfoot R, Polydoro M, Spielberg D, Thomson L, Regan EA, Crapo J, Ischiropoulos H. Subcellular localization of tyrosine-nitrated proteins is dictated by reactive oxygen species generating enzymes and by proximity to nitric oxide synthase. Free Radical Biology & Medicine. 40: 1903-13. PMID 16716892 DOI: 10.1016/j.freeradbiomed.2005.09.006  0.64
2006 Ferreira AR, Bonatto F, de Bittencourt Pasquali MA, Polydoro M, Dal-Pizzol F, Fernández C, de Salles AA, Moreira JC. Oxidative stress effects on the central nervous system of rats after acute exposure to ultra high frequency electromagnetic fields. Bioelectromagnetics. 27: 487-93. PMID 16715528 DOI: 10.1002/bem.20233  0.64
2005 de Lima MN, Polydoro M, Laranja DC, Bonatto F, Bromberg E, Moreira JC, Dal-Pizzol F, Schröder N. Recognition memory impairment and brain oxidative stress induced by postnatal iron administration. The European Journal of Neuroscience. 21: 2521-8. PMID 15932609 DOI: 10.1111/j.1460-9568.2005.04083.x  0.64
2005 de Oliveira RB, Klamt F, Castro MA, Polydoro M, Zanotto Filho A, Gelain DP, Dal-Pizzol F, Moreira JC. Morphological and oxidative alterations on Sertoli cells cytoskeleton due to retinol-induced reactive oxygen species. Molecular and Cellular Biochemistry. 271: 189-96. PMID 15881670 DOI: 10.1007/s11010-005-6339-z  0.64
2005 Bonatto F, Polydoro M, Andrades ME, da Frota Júnior ML, Dal-Pizzol F, Rotta LN, Souza DO, Perry ML, Moreira JC. Effect of protein malnutrition on redox state of the hippocampus of rat. Brain Research. 1042: 17-22. PMID 15823248 DOI: 10.1016/j.brainres.2005.02.002  0.64
2004 Polydoro M, Schröder N, Lima MN, Caldana F, Laranja DC, Bromberg E, Roesler R, Quevedo J, Moreira JC, Dal-Pizzol F. Haloperidol- and clozapine-induced oxidative stress in the rat brain. Pharmacology, Biochemistry, and Behavior. 78: 751-6. PMID 15301931 DOI: 10.1016/j.pbb.2004.05.018  0.64
2004 Polydoro M, de Souza KC, Andrades ME, Da Silva EG, Bonatto F, Heydrich J, Dal-Pizzol F, Schapoval EE, Bassani VL, Moreira JC. Antioxidant, a pro-oxidant and cytotoxic effects of Achyrocline satureioides extracts. Life Sciences. 74: 2815-26. PMID 15050420 DOI: 10.1016/j.lfs.2003.09.073  0.64
2003 Ritter C, Andrades M, Frota Júnior ML, Bonatto F, Pinho RA, Polydoro M, Klamt F, Pinheiro CT, Menna-Barreto SS, Moreira JC, Dal-Pizzol F. Oxidative parameters and mortality in sepsis induced by cecal ligation and perforation. Intensive Care Medicine. 29: 1782-9. PMID 12783160 DOI: 10.1007/s00134-003-1789-9  0.64
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