Junying Yuan, Ph.D - Publications

Harvard Medical School, Boston, MA, United States 
Mechanisms of Programmed Cell Death

262 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Klionsky DJ, Petroni G, Amaravadi RK, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, Cadwell K, Cecconi F, Choi AMK, Choi ME, Chu CT, Codogno P, Colombo MI, Cuervo AM, ... ... Yuan J, et al. Autophagy in major human diseases. The Embo Journal. e108863. PMID 34459017 DOI: 10.15252/embj.2021108863  1
2021 Wang H, Qi W, Zou C, Xie Z, Zhang M, Naito MG, Mifflin L, Liu Z, Najafov A, Pan H, Shan B, Li Y, Zhu ZJ, Yuan J. NEK1-mediated retromer trafficking promotes blood-brain barrier integrity by regulating glucose metabolism and RIPK1 activation. Nature Communications. 12: 4826. PMID 34376696 DOI: 10.1038/s41467-021-25157-7  1
2021 Meng H, Wu G, Zhao X, Wang A, Li D, Tong Y, Jin T, Cao Y, Shan B, Hu S, Li Y, Pan L, Tian X, Wu P, Peng C, ... Yuan J, et al. Discovery of a cooperative mode of inhibiting RIPK1 kinase. Cell Discovery. 7: 41. PMID 34075030 DOI: 10.1038/s41421-021-00278-x  1
2021 Yuan J, Zhang B, Xu Y, Zhang X, Song J, Zhou W, Hu K, Zhu D, Zhang L, Shao F, Zhang S, Ding J, Zhu C. Population Pharmacokinetics of Lithium in Young Pediatric Patients With Intellectual Disability. Frontiers in Pharmacology. 12: 650298. PMID 33935755 DOI: 10.3389/fphar.2021.650298  1
2021 Huang X, Tan S, Li Y, Cao S, Li X, Pan H, Shan B, Qian L, Yuan J. Caspase inhibition prolongs inflammation by promoting a signaling complex with activated RIPK1. The Journal of Cell Biology. 220. PMID 33914027 DOI: 10.1083/jcb.202007127  1
2021 Mifflin L, Hu Z, Dufort C, Hession CC, Walker AJ, Niu K, Zhu H, Liu N, Liu JS, Levin JZ, Stevens B, Yuan J, Zou C. A RIPK1-regulated inflammatory microglial state in amyotrophic lateral sclerosis. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33766915 DOI: 10.1073/pnas.2025102118  1
2021 Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, ... Yuan J, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy. 1-382. PMID 33634751 DOI: 10.1080/15548627.2020.1797280  1
2020 Li X, Zhang M, Huang X, Liang W, Li G, Lu X, Li Y, Pan H, Shi L, Zhu H, Qian L, Shan B, Yuan J. Ubiquitination of RIPK1 regulates its activation mediated by TNFR1 and TLRs signaling in distinct manners. Nature Communications. 11: 6364. PMID 33311474 DOI: 10.1038/s41467-020-19935-y  1
2020 Zou C, Mifflin L, Hu Z, Zhang T, Shan B, Wang H, Xing X, Zhu H, Adiconis X, Levin JZ, Li F, Liu CF, Liu JS, Yuan J. Reduction of mNAT1/hNAT2 Contributes to Cerebral Endothelial Necroptosis and Aβ Accumulation in Alzheimer's Disease. Cell Reports. 33: 108447. PMID 33296651 DOI: 10.1016/j.celrep.2020.108447  1
2020 Najafov A, Luu HS, Mookhtiar AK, Mifflin L, Xia HG, Amin PP, Ordureau A, Wang H, Yuan J. RIPK1 Promotes Energy Sensing by the mTORC1 Pathway. Molecular Cell. PMID 33271062 DOI: 10.1016/j.molcel.2020.11.008  1
2020 Xu D, Zhao H, Jin M, Zhu H, Shan B, Geng J, Dziedzic SA, Amin P, Mifflin L, Naito MG, Najafov A, Xing J, Yan L, Liu J, Qin Y, ... Yuan J, et al. Modulating TRADD to restore cellular homeostasis and inhibit apoptosis. Nature. PMID 32968279 DOI: 10.1038/s41586-020-2757-z  1
2020 Mifflin L, Ofengeim D, Yuan J. Receptor-interacting protein kinase 1 (RIPK1) as a therapeutic target. Nature Reviews. Drug Discovery. PMID 32669658 DOI: 10.1038/S41573-020-0071-Y  1
2020 Huang H, Jin WW, Huang M, Ji H, Capen DE, Xia Y, Yuan J, Păunescu TG, Lu HAJ. Gentamicin-Induced Acute Kidney Injury in an Animal Model Involves Programmed Necrosis of the Collecting Duct. Journal of the American Society of Nephrology : Jasn. PMID 32641397 DOI: 10.1681/ASN.2019020204  0.08
2020 Tan S, Zhao J, Sun Z, Cao S, Niu K, Zhong Y, Wang H, Shi L, Pan H, Hu J, Qian L, Liu N, Yuan J. Hepatocyte-specific TAK1 deficiency drives RIPK1 kinase-dependent inflammation to promote liver fibrosis and hepatocellular carcinoma. Proceedings of the National Academy of Sciences of the United States of America. PMID 32513687 DOI: 10.1073/Pnas.2005353117  1
2020 Naito MG, Xu D, Amin P, Lee J, Wang H, Li W, Kelliher M, Pasparakis M, Yuan J. Sequential activation of necroptosis and apoptosis cooperates to mediate vascular and neural pathology in stroke. Proceedings of the National Academy of Sciences of the United States of America. PMID 32071228 DOI: 10.1073/Pnas.1916427117  1
2019 Tao P, Sun J, Wu Z, Wang S, Wang J, Li W, Pan H, Bai R, Zhang J, Wang Y, Lee PY, Ying W, Zhou Q, Hou J, Wang W, ... ... Yuan J, et al. A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1. Nature. PMID 31827280 DOI: 10.1038/S41586-019-1830-Y  1
2019 Lee SY, Kim H, Li CM, Kang J, Najafov A, Jung M, Kang S, Wang S, Yuan J, Jung YK. Casein kinase-1γ1 and 3 stimulate tumor necrosis factor-induced necroptosis through RIPK3. Cell Death & Disease. 10: 923. PMID 31801942 DOI: 10.1038/S41419-019-2146-4  1
2019 Najafov A, Mookhtiar AK, Luu HS, Ordureau A, Pan H, Amin PP, Li Y, Lu Q, Yuan J. TAM Kinases Promote Necroptosis by Regulating Oligomerization of MLKL. Molecular Cell. PMID 31230815 DOI: 10.1016/J.Molcel.2019.05.022  1
2019 Degterev A, Ofengeim D, Yuan J. Targeting RIPK1 for the treatment of human diseases. Proceedings of the National Academy of Sciences of the United States of America. PMID 31048504 DOI: 10.1073/Pnas.1901179116  1
2019 Wu Z, Geng Y, Lu X, Shi Y, Wu G, Zhang M, Shan B, Pan H, Yuan J. Chaperone-mediated autophagy is involved in the execution of ferroptosis. Proceedings of the National Academy of Sciences of the United States of America. PMID 30718432 DOI: 10.1073/Pnas.1819728116  1
2018 Yuan J, Song J, Zhu D, Sun E, Xia L, Zhang X, Gao C, Agam G, Wang X, Blomgren K, Zhu C. Lithium Treatment Is Safe in Children With Intellectual Disability. Frontiers in Molecular Neuroscience. 11: 425. PMID 30524233 DOI: 10.3389/fnmol.2018.00425  1
2018 Wei R, Xu LW, Liu J, Li Y, Zhang P, Shan B, Lu X, Qian L, Wu Z, Dong K, Zhu H, Pan L, Yuan J, Pan H. Corrigendum: SPATA2 regulates the activation of RIPK1 by modulating linear ubiquitination. Genes & Development. 32: 1591. PMID 30509949 DOI: 10.1101/Gad.321075.118  1
2018 Yuan J, Amin P, Ofengeim D. Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases. Nature Reviews. Neuroscience. PMID 30467385 DOI: 10.1038/S41583-018-0093-1  1
2018 Su Z, Dziedzic SA, Hu D, Barrett VJ, Broekema N, Li W, Qian L, Jia N, Ofengeim D, Najafov A, Zhu H, Knipe DM, Yuan J. ABIN-1 heterozygosity sensitizes to innate immune response in both RIPK1-dependent and RIPK1-independent manner. Cell Death and Differentiation. PMID 30341420 DOI: 10.1038/S41418-018-0215-3  1
2018 Yuan J, Wang J, Ma J, Zhu D, Zhang Z, Li J. Peadiatric cerebral palsy prevalence and high-risk factors in Henan Province, Central China. Journal of Rehabilitation Medicine. PMID 30299526 DOI: 10.2340/16501977-2486  1
2018 Li H, Fang Y, Niu C, Cao H, Mi T, Zhu H, Yuan J, Zhu J. Inhibition of cIAP1 as a strategy for targeting c-MYC-driven oncogenic activity. Proceedings of the National Academy of Sciences of the United States of America. PMID 30181285 DOI: 10.1073/Pnas.1807711115  1
2018 Najafov A, Zervantonakis IK, Mookhtiar AK, Greninger P, March RJ, Egan RK, Luu HS, Stover DG, Matulonis UA, Benes CH, Yuan J. BRAF and AXL oncogenes drive RIPK3 expression loss in cancer. Plos Biology. 16: e2005756. PMID 30157175 DOI: 10.1371/Journal.Pbio.2005756  1
2018 Xu D, Jin T, Zhu H, Chen H, Ofengeim D, Zou C, Mifflin L, Pan L, Amin P, Li W, Shan B, Naito MG, Meng H, Li Y, Pan H, ... ... Yuan J, et al. TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging. Cell. PMID 30146158 DOI: 10.1016/J.Cell.2018.07.041  1
2018 Wang Y, Shan B, Liang Y, Wei H, Yuan J. Parkin regulates NF-κB by mediating site-specific ubiquitination of RIPK1. Cell Death & Disease. 9: 732. PMID 29955050 DOI: 10.1038/S41419-018-0770-Z  1
2018 Amin P, Florez M, Najafov A, Pan H, Geng J, Ofengeim D, Dziedzic SA, Wang H, Barrett VJ, Ito Y, LaVoie MJ, Yuan J. Regulation of a distinct activated RIPK1 intermediate bridging complex I and complex II in TNFα-mediated apoptosis. Proceedings of the National Academy of Sciences of the United States of America. PMID 29891719 DOI: 10.1073/Pnas.1806973115  1
2018 Zhu K, Liang W, Ma Z, Xu D, Cao S, Lu X, Liu N, Shan B, Qian L, Yuan J. Necroptosis promotes cell-autonomous activation of proinflammatory cytokine gene expression. Cell Death & Disease. 9: 500. PMID 29703889 DOI: 10.1038/S41419-018-0524-Y  1
2018 Shan B, Pan H, Najafov A, Yuan J. Necroptosis in development and diseases. Genes & Development. 32: 327-340. PMID 29593066 DOI: 10.1101/Gad.312561.118  1
2018 Meng H, Liu Z, Li X, Wang H, Jin T, Wu G, Shan B, Christofferson DE, Qi C, Yu Q, Li Y, Yuan J. Death-domain dimerization-mediated activation of RIPK1 controls necroptosis and RIPK1-dependent apoptosis. Proceedings of the National Academy of Sciences of the United States of America. PMID 29440439 DOI: 10.1073/Pnas.1722013115  1
2018 Li F, Xu D, Wang Y, Zhou Z, Liu J, Hu S, Gong Y, Yuan J, Pan L. Structural insights into the ubiquitin recognition by OPTN (optineurin) and its regulation by TBK1-mediated phosphorylation. Autophagy. 1-14. PMID 29394115 DOI: 10.1080/15548627.2017.1391970  1
2018 Ouchida AT, Li Y, Geng J, Najafov A, Ofengeim D, Sun X, Yu Q, Yuan J. Synergistic effect of a novel autophagy inhibitor and Quizartinib enhances cancer cell death. Cell Death & Disease. 9: 138. PMID 29374185 DOI: 10.1038/S41419-017-0170-9  1
2018 Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, ... Yuan J, et al. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death and Differentiation. PMID 29362479 DOI: 10.1038/S41418-017-0012-4  1
2017 Dziedzic SA, Su Z, Jean Barrett V, Najafov A, Mookhtiar AK, Amin P, Pan H, Sun L, Zhu H, Ma A, Abbott DW, Yuan J. ABIN-1 regulates RIPK1 activation by linking Met1 ubiquitylation with Lys63 deubiquitylation in TNF-RSC. Nature Cell Biology. PMID 29203883 DOI: 10.1038/S41556-017-0003-1  1
2017 Wang H, Meng H, Li X, Zhu K, Dong K, Mookhtiar AK, Wei H, Li Y, Sun SC, Yuan J. PELI1 functions as a dual modulator of necroptosis and apoptosis by regulating ubiquitination of RIPK1 and mRNA levels of c-FLIP. Proceedings of the National Academy of Sciences of the United States of America. PMID 29078411 DOI: 10.1073/Pnas.1715742114  1
2017 Ofengeim D, Mazzitelli S, Ito Y, DeWitt JP, Mifflin L, Zou C, Das S, Adiconis X, Chen H, Zhu H, Kelliher MA, Levin JZ, Yuan J. RIPK1 mediates a disease-associated microglial response in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 28904096 DOI: 10.1073/Pnas.1714175114  1
2017 Geng J, Ito Y, Shi L, Amin P, Chu J, Ouchida AT, Mookhtiar AK, Zhao H, Xu D, Shan B, Najafov A, Gao G, Akira S, Yuan J. Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis. Nature Communications. 8: 359. PMID 28842570 DOI: 10.1038/S41467-017-00406-W  1
2017 Li Y, Yuan J. Systematic Metrics Depicting Cell Death Kinetics. Cell Chemical Biology. 24: 785-786. PMID 28732200 DOI: 10.1016/J.Chembiol.2017.07.006  1
2017 Wei R, Xu LW, Liu J, Li Y, Zhang P, Shan B, Lu X, Qian L, Wu Z, Dong K, Zhu H, Pan L, Yuan J, Pan H. SPATA2 regulates the activation of RIPK1 by modulating linear ubiquitination. Genes & Development. PMID 28701375 DOI: 10.1101/Gad.299776.117  1
2017 Li Y, Qian L, Yuan J. Small molecule probes for cellular death machines. Current Opinion in Chemical Biology. 39: 74-82. PMID 28628894 DOI: 10.1016/J.Cbpa.2017.05.007  1
2017 Xu D, Liu J, Fu T, Shan B, Qian L, Pan L, Yuan J. USP25 regulates Wnt signaling by controlling the stability of tankyrases. Genes & Development. PMID 28619731 DOI: 10.1101/Gad.300889.117  1
2017 Galluzzi L, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, Cecconi F, Choi AM, Chu CT, Codogno P, Colombo MI, Cuervo AM, Debnath J, Deretic V, Dikic I, Eskelinen EL, ... Yuan J, et al. Molecular definitions of autophagy and related processes. The Embo Journal. PMID 28596378 DOI: 10.15252/Embj.201796697  1
2017 Ofengeim D, Giagtzoglou N, Huh D, Zou C, Yuan J. Single-Cell RNA Sequencing: Unraveling the Brain One Cell at a Time. Trends in Molecular Medicine. PMID 28501348 DOI: 10.1016/J.Molmed.2017.04.006  1
2017 Najafov A, Chen H, Yuan J. Necroptosis and Cancer. Trends in Cancer. 3: 294-301. PMID 28451648 DOI: 10.1016/J.Trecan.2017.03.002  1
2016 Yuan J, Najafov A, Py BF. Roles of Caspases in Necrotic Cell Death. Cell. 167: 1693-1704. PMID 27984721 DOI: 10.1016/J.Cell.2016.11.047  1
2016 Afonso MB, Rodrigues PM, Simão AL, Ofengeim D, Carvalho T, Amaral JD, Gaspar MM, Cortez-Pinto H, Castro RE, Yuan J, Rodrigues CM. Activation of necroptosis in human and experimental cholestasis. Cell Death & Disease. 7: e2390. PMID 27685634 DOI: 10.1038/Cddis.2016.280  1
2016 Xu D, Shan B, Sun H, Xiao J, Zhu K, Xie X, Li X, Liang W, Lu X, Qian L, Yuan J. USP14 regulates autophagy by suppressing K63 ubiquitination of Beclin 1. Genes & Development. 30: 1718-30. PMID 27542828 DOI: 10.1101/Gad.285122.116  1
2016 Ito Y, Ofengeim D, Najafov A, Das S, Saberi S, Li Y, Hitomi J, Zhu H, Chen H, Mayo L, Geng J, Amin P, DeWitt JP, Mookhtiar AK, Florez M, ... Yuan J, et al. RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS. Science (New York, N.Y.). 353: 603-8. PMID 27493188 DOI: 10.1126/Science.Aaf6803  1
2016 Vakifahmetoglu-Norberg H, Kim M, Xia HG, Iwanicki MP, Ofengeim D, Coloff JL, Pan L, Ince TA, Kroemer G, Brugge JS, Yuan J. Corrigendum: Chaperone-mediated autophagy degrades mutant p53. Genes & Development. 30: 870. PMID 27036968 DOI: 10.1101/Gad.280453.116  1
2016 Xia HG, Najafov A, Geng J, Galan-Acosta L, Han X, Guo Y, Shan B, Zhang Y, Norberg E, Zhang T, Pan L, Liu J, Coloff JL, Ofengeim D, Zhu H, ... Yuan J, et al. Correction: Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death. The Journal of Cell Biology. PMID 27002169 DOI: 10.1083/Jcb.20150304403082016C  1
2016 Klionsky DJ, Abdelmohsen K, Abe A, Abedin J, Abeliovich H, Arozena AA, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... Yuan J, et al. Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356 Autophagy. 12: 443-443. PMID 26902590 DOI: 10.1080/15548627.2016.1147886  1
2016 Zhu D, Wang M, Wang J, Yuan J, Niu G, Zhang G, Sun L, Xiong H, Xie M, Zhao Y. Ketogenic diet effects on neurobehavioral development of children with intractable epilepsy: A prospective study. Epilepsy & Behavior : E&B. 55: 87-91. PMID 26773676 DOI: 10.1016/j.yebeh.2015.12.011  1
2016 Afonso M, Rodrigues P, Simão A, Cortez-Pinto H, Ofengeim D, Amaral J, Castro R, Yuan J, Rodrigues C. RIP3 Regulates Acute Cholestasis-Associated Necroptotic Signaling and Cell Death Journal of Hepatology. 64: S349. DOI: 10.1016/S0168-8278(16)00504-3  1
2015 Galan-Acosta L, Xia H, Yuan J, Vakifahmetoglu-Norberg H. Activation of chaperone-mediated autophagy as a potential anticancer therapy. Autophagy. 0. PMID 26577179 DOI: 10.1080/15548627.2015.1106666  1
2015 Xu D, Shan B, Lee BH, Zhu K, Zhang T, Sun H, Liu M, Shi L, Liang W, Qian L, Xiao J, Wang L, Pan L, Finley D, Yuan J. Phosphorylation and activation of ubiquitin-specific protease-14 by Akt regulates the ubiquitin-proteasome system. Elife. 4. PMID 26523394 DOI: 10.7554/Elife.10510  1
2015 Xia HG, Najafov A, Geng J, Galan-Acosta L, Han X, Guo Y, Shan B, Zhang Y, Norberg E, Zhang T, Pan L, Liu J, Coloff JL, Ofengeim D, Zhu H, ... ... Yuan J, et al. Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death. The Journal of Cell Biology. 210: 705-16. PMID 26323688 DOI: 10.1083/Jcb.201503044  1
2015 Mou J, Park A, Cai Y, Yuan J, Yuan C. Structure-activity relationship study of E6 as a novel necroptosis inducer. Bioorganic & Medicinal Chemistry Letters. 25: 3057-61. PMID 26048796 DOI: 10.1016/J.Bmcl.2015.04.038  1
2015 Jin K, He G, Zhang X, Maruyama S, Yasui S, Suchoski R, Shin J, Jiang Y, Yu HS, Yuan J, Shan L, Kusmartsev FV, Greene RL, Takeuchi I. Anomalous magnetoresistance in the spinel superconductor LiTi2O4. Nature Communications. 6: 7183. PMID 25990638 DOI: 10.1038/Ncomms8183  1
2015 Xu D, Zhang T, Xiao J, Zhu K, Wei R, Wu Z, Meng H, Li Y, Yuan J. Modification of BECN1 by ISG15 plays a crucial role in autophagy regulation by type I IFN/interferon. Autophagy. 11: 617-28. PMID 25906440 DOI: 10.1080/15548627.2015.1023982  1
2015 Nah J, Yuan J, Jung YK. Autophagy in Neurodegenerative Diseases: From Mechanism to Therapeutic Approach. Molecules and Cells. 38: 381-389. PMID 25896254 DOI: 10.14348/Molcells.2015.0034  1
2015 Zhang T, Dong K, Liang W, Xu D, Xia H, Geng J, Najafov A, Liu M, Li Y, Han X, Xiao J, Jin Z, Peng T, Gao Y, Cai Y, ... ... Yuan J, et al. G-protein-coupled receptors regulate autophagy by ZBTB16-mediated ubiquitination and proteasomal degradation of Atg14L. Elife. 4: e06734. PMID 25821988 DOI: 10.7554/Elife.06734  1
2015 Najjar M, Suebsuwong C, Ray SS, Thapa RJ, Maki JL, Nogusa S, Shah S, Saleh D, Gough PJ, Bertin J, Yuan J, Balachandran S, Cuny GD, Degterev A. Structure guided design of potent and selective ponatinib-based hybrid inhibitors for RIPK1. Cell Reports. 10: 1850-60. PMID 25801024 DOI: 10.1016/J.Celrep.2015.02.052  1
2015 Ofengeim D, Ito Y, Najafov A, Zhang Y, Shan B, DeWitt JP, Ye J, Zhang X, Chang A, Vakifahmetoglu-Norberg H, Geng J, Py B, Zhou W, Amin P, Berlink Lima J, ... ... Yuan J, et al. Activation of necroptosis in multiple sclerosis. Cell Reports. 10: 1836-49. PMID 25801023 DOI: 10.1016/J.Celrep.2015.02.051  1
2015 Vakifahmetoglu-Norberg H, Xia HG, Yuan J. Pharmacologic agents targeting autophagy. The Journal of Clinical Investigation. 125: 5-13. PMID 25654545 DOI: 10.1172/Jci73937  1
2015 Xiao J, Zhang T, Xu D, Wang H, Cai Y, Jin T, Liu M, Jin M, Wu K, Yuan J. FBXL20-mediated Vps34 ubiquitination as a p53 controlled checkpoint in regulating autophagy and receptor degradation. Genes & Development. 29: 184-96. PMID 25593308 DOI: 10.1101/Gad.252528.114  1
2015 Xu D, Shan B, Lee B, Zhu K, Zhang T, Sun H, Liu M, Shi L, Liang W, Qian L, Xiao J, Wang L, Pan L, Finley D, Yuan J. Author response: Phosphorylation and activation of ubiquitin-specific protease-14 by Akt regulates the ubiquitin-proteasome system Elife. DOI: 10.7554/Elife.10510.018  1
2015 Zhang T, Dong K, Liang W, Xu D, Xia H, Geng J, Najafov A, Liu M, Li Y, Han X, Xiao J, Jin Z, Peng T, Gao Y, Cai Y, ... ... Yuan J, et al. Author response: G-protein-coupled receptors regulate autophagy by ZBTB16-mediated ubiquitination and proteasomal degradation of Atg14L Elife. DOI: 10.7554/Elife.06734.017  1
2015 Afonso M, Rodrigues P, Simão A, Cortez-Pinto H, Ofengeim D, Amaral J, Castro R, Yuan J, Rodrigues C. P1193 : Necroptosis contributes to the pathogenesis of cholestatic liver injury Journal of Hepatology. 62: S802-S803. DOI: 10.1016/S0168-8278(15)31389-1  1
2014 Zhou W, Yuan J. Necroptosis in health and diseases. Seminars in Cell & Developmental Biology. 35: 14-23. PMID 25087983 DOI: 10.1016/J.Semcdb.2014.07.013  1
2014 Ashkenazi A, Wells JA, Yuan J. Methods in Enzymology. Regulated cell death part B--necroptotic, autophagic and other non-apoptotic mechanisms. Preface. Methods in Enzymology. 545: xiii. PMID 25065895 DOI: 10.1016/B978-0-12-801430-1.10000-9  1
2014 Degterev A, Zhou W, Maki JL, Yuan J. Assays for necroptosis and activity of RIP kinases. Methods in Enzymology. 545: 1-33. PMID 25065884 DOI: 10.1016/B978-0-12-801430-1.00001-9  1
2014 Zhou W, Yuan J. SnapShot: Necroptosis. Cell. 158: 464-464.e1. PMID 25036639 DOI: 10.1016/j.cell.2014.06.041  1
2014 Ashkenazi A, Yuan J, Wells JA. Regulated cell death part A: apoptotic mechanisms. Preface. Methods in Enzymology. 544: xv. PMID 24974300 DOI: 10.1016/B978-0-12-417158-9.10000-7  1
2014 Py BF, Jin M, Desai BN, Penumaka A, Zhu H, Kober M, Dietrich A, Lipinski MM, Henry T, Clapham DE, Yuan J. Caspase-11 controls interleukin-1β release through degradation of TRPC1. Cell Reports. 6: 1122-8. PMID 24630989 DOI: 10.1016/J.Celrep.2014.02.015  1
2014 Christofferson DE, Li Y, Yuan J. Control of life-or-death decisions by RIP1 kinase. Annual Review of Physiology. 76: 129-50. PMID 24079414 DOI: 10.1146/Annurev-Physiol-021113-170259  1
2013 Vakifahmetoglu-Norberg H, Yuan J. A degradative detour for mutant TP53. Autophagy. 9: 2158-60. PMID 24145670 DOI: 10.4161/Auto.26338  1
2013 Ofengeim D, Yuan J. Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death. Nature Reviews. Molecular Cell Biology. 14: 727-36. PMID 24129419 DOI: 10.1038/Nrm3683  1
2013 Kam TI, Song S, Gwon Y, Park H, Yan JJ, Im I, Choi JW, Choi TY, Kim J, Song DK, Takai T, Kim YC, Kim KS, Choi SY, Choi S, ... ... Yuan J, et al. FcγRIIb mediates amyloid-β neurotoxicity and memory impairment in Alzheimer's disease. The Journal of Clinical Investigation. 123: 2791-802. PMID 23921129 DOI: 10.1172/Jci66827  1
2013 Vakifahmetoglu-Norberg H, Kim M, Xia HG, Iwanicki MP, Ofengeim D, Coloff JL, Pan L, Ince TA, Kroemer G, Brugge JS, Yuan J. Chaperone-mediated autophagy degrades mutant p53. Genes & Development. 27: 1718-30. PMID 23913924 DOI: 10.1101/Gad.220897.113  1
2013 Wu Z, Li Y, Cai Y, Yuan J, Yuan C. A novel necroptosis inhibitor-necrostatin-21 and its SAR study. Bioorganic & Medicinal Chemistry Letters. 23: 4903-6. PMID 23886688 DOI: 10.1016/J.Bmcl.2013.06.073  1
2013 Xu Y, Yuan J, Lipinski MM. Live imaging and single-cell analysis reveal differential dynamics of autophagy and apoptosis. Autophagy. 9: 1418-30. PMID 23748697 DOI: 10.4161/Auto.25080  1
2013 Py BF, Gonzalez SF, Long K, Kim MS, Kim YA, Zhu H, Yao J, Degauque N, Villet R, Ymele-Leki P, Gadjeva M, Pier GB, Carroll MC, Yuan J. Cochlin produced by follicular dendritic cells promotes antibacterial innate immunity. Immunity. 38: 1063-72. PMID 23684986 DOI: 10.1016/J.Immuni.2013.01.015  1
2013 Xie T, Peng W, Liu Y, Yan C, Maki J, Degterev A, Yuan J, Shi Y. Structural basis of RIP1 inhibition by necrostatins. Structure (London, England : 1993). 21: 493-9. PMID 23473668 DOI: 10.1016/J.Str.2013.01.016  1
2013 Py BF, Kim MS, Vakifahmetoglu-Norberg H, Yuan J. Deubiquitination of NLRP3 by BRCC3 critically regulates inflammasome activity. Molecular Cell. 49: 331-8. PMID 23246432 DOI: 10.1016/J.Molcel.2012.11.009  1
2013 Degterev A, Maki JL, Yuan J. Activity and specificity of necrostatin-1, small-molecule inhibitor of RIP1 kinase. Cell Death and Differentiation. 20: 366. PMID 23197295 DOI: 10.1038/Cdd.2012.133  1
2013 Mateo R, Nagamine CM, Spagnolo J, Méndez E, Rahe M, Gale M, Yuan J, Kirkegaard K. Inhibition of cellular autophagy deranges dengue virion maturation. Journal of Virology. 87: 1312-21. PMID 23175363 DOI: 10.1128/Jvi.02177-12  0.01
2013 Yuan J, Sun X, Luo M. Xiaocheng Gu (1930-2012) Cell Research. 23: 167-167. DOI: 10.1038/Cr.2013.18  1
2013 Liu Y-, Dong C-, Yang G-, Li H-, Yao S-, Lin Y-, Yuan J, Zhou B-. 726 Virtual Touch Tissue Quantification For Noninvasive Assessment Of Liver Fibrosis In Chronic Hepatitis B Journal of Hepatology. 58. DOI: 10.1016/S0168-8278(13)60728-X  0.04
2012 Zhou W, Yuan J. Cell biology: Death by deacetylation. Nature. 492: 194-5. PMID 23201692 DOI: 10.1038/Nature11761  1
2012 Takahashi N, Duprez L, Grootjans S, Cauwels A, Nerinckx W, Duhadaway JB, Goossens V, Roelandt R, Van Hauwermeiren F, Libert C, Declercq W, Callewaert N, Prendergast GC, Degterev A, Yuan J, et al. Necrostatin-1 analogues: Critical issues on the specificity, activity and in vivo use in experimental disease models Cell Death and Disease. 3. PMID 23190609 DOI: 10.1038/Cddis.2012.176  1
2012 Choi S, Keys H, Staples RJ, Yuan J, Degterev A, Cuny GD. Optimization of tricyclic Nec-3 necroptosis inhibitors for in vitro liver microsomal stability. Bioorganic & Medicinal Chemistry Letters. 22: 5685-8. PMID 22832318 DOI: 10.1016/J.Bmcl.2012.06.098  1
2012 Gu Y, Sun XX, Ye JM, He L, Yan SS, Zhang HH, Hu LH, Yuan JY, Yu Q. Arctigenin alleviates ER stress via activating AMPK Acta Pharmacologica Sinica. 33: 941-952. PMID 22705729 DOI: 10.1038/Aps.2012.60  1
2012 Christofferson DE, Li Y, Hitomi J, Zhou W, Upperman C, Zhu H, Gerber SA, Gygi S, Yuan J. A novel role for RIP1 kinase in mediating TNFa production Cell Death and Disease. 3. PMID 22695613 DOI: 10.1038/Cddis.2012.64  1
2012 Gu Y, Qi C, Sun X, Ma X, Zhang H, Hu L, Yuan J, Yu Q. Arctigenin preferentially induces tumor cell death under glucose deprivation by inhibiting cellular energy metabolism. Biochemical Pharmacology. 84: 468-76. PMID 22687625 DOI: 10.1016/J.Bcp.2012.06.002  1
2012 Hyman BT, Yuan J. Apoptotic and non-apoptotic roles of caspases in neuronal physiology and pathophysiology. Nature Reviews. Neuroscience. 13: 395-406. PMID 22595785 DOI: 10.1038/Nrn3228  1
2012 Ofengeim D, Shi P, Miao B, Fan J, Xia X, Fan Y, Lipinski MM, Hashimoto T, Polydoro M, Yuan J, Wong ST, Degterev A. Identification of small molecule inhibitors of neurite loss induced by Aβ peptide using high content screening. The Journal of Biological Chemistry. 287: 8714-23. PMID 22277654 DOI: 10.1074/Jbc.M111.290957  1
2012 Miao B, Skidan I, Yang J, You Z, Fu X, Famulok M, Schaffhausen B, Torchilin V, Yuan J, Degterev A. Inhibition of cell migration by PITENINs: The role of ARF6 Oncogene. 31: 4317-4332. PMID 22179837 DOI: 10.1038/Onc.2011.593  1
2012 Yuan J, Vakifahmetoglu-Norberg H, Xia H, Liu J, Li Y, Kim M, Ma D. Abstract SY36-03: Development of small-molecule inhibitors of autophagy as anticancer therapy Cancer Research. 72. DOI: 10.1158/1538-7445.Am2012-Sy36-03  1
2012 Maki JL, Teng X, Smith EE, Ray S, Yuan J, Cuny GD, Degterev A. Abstract SY27-03: Development of necrostatins, small molecule inhibitors of RIP1-kinase signaling and necroptosis Cancer Research. 72. DOI: 10.1158/1538-7445.Am2012-Sy27-03  1
2011 Ma X, Jin M, Cai Y, Xia H, Long K, Liu J, Yu Q, Yuan J. Mitochondrial electron transport chain complex III is required for antimycin A to inhibit autophagy. Chemistry & Biology. 18: 1474-81. PMID 22118681 DOI: 10.1016/J.Chembiol.2011.08.009  1
2011 Yi CH, Vakifahmetoglu-Norberg H, Yuan J. Integration of apoptosis and metabolism. Cold Spring Harbor Symposia On Quantitative Biology. 76: 375-87. PMID 22089928 DOI: 10.1101/Sqb.2011.76.010777  1
2011 Liu J, Xia H, Kim M, Xu L, Li Y, Zhang L, Cai Y, Norberg HV, Zhang T, Furuya T, Jin M, Zhu Z, Wang H, Yu J, Li Y, ... ... Yuan J, et al. Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. Cell. 147: 223-34. PMID 21962518 DOI: 10.1016/J.Cell.2011.08.037  1
2011 Yi CH, Pan H, Seebacher J, Jang IH, Hyberts SG, Heffron GJ, Vander Heiden MG, Yang R, Li F, Locasale JW, Sharfi H, Zhai B, Rodriguez-Mias R, Luithardt H, Cantley LC, ... ... Yuan J, et al. Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival. Cell. 146: 607-20. PMID 21854985 DOI: 10.1016/J.Cell.2011.06.050  1
2011 Kepp O, Galluzzi L, Lipinski M, Yuan J, Kroemer G. Cell death assays for drug discovery. Nature Reviews. Drug Discovery. 10: 221-37. PMID 21358741 DOI: 10.1038/Nrd3373  1
2011 Sun X, Wu Y, Chen B, Zhang Z, Zhou W, Tong Y, Yuan J, Xia K, Gronemeyer H, Flavell RA, Song W. Regulator of calcineurin 1 (RCAN1) facilitates neuronal apoptosis through caspase-3 activation. The Journal of Biological Chemistry. 286: 9049-62. PMID 21216952 DOI: 10.1074/Jbc.M110.177519  1
2011 Chen G, Xia H, Cai Y, Ma D, Yuan J, Yuan C. Synthesis and SAR study of diphenylbutylpiperidines as cell autophagy inducers. Bioorganic & Medicinal Chemistry Letters. 21: 234-9. PMID 21126871 DOI: 10.1016/J.Bmcl.2010.11.029  1
2011 Han S, Pan H, Zhang J, Tan L, Ma D, Yuan J, Wu JR. Identification of a small molecule activator of novel PKCs for promoting glucose-dependent insulin secretion. Cell Research. 21: 588-99. PMID 20877311 DOI: 10.1038/Cr.2010.137  1
2011 Lipinski M, Furuya T, Kim M, Hoffman G, Ng A, Blenis J, Xavior R, Yuan J. Abstract SY09-01: Control of class III PI 3-kinase in autophagy and cancers Cancer Research. 71. DOI: 10.1158/1538-7445.Am2011-Sy09-01  1
2010 Miao B, Skidan I, Yang J, Lugovskoy A, Reibarkh M, Long K, Brazell T, Durugkar KA, Maki J, Ramana CV, Schaffhausen B, Wagner G, Torchilin V, Yuan J, Degterev A. Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains. Proceedings of the National Academy of Sciences of the United States of America. 107: 20126-31. PMID 21041639 DOI: 10.1073/Pnas.1004522107  1
2010 Lipinski MM, Zheng B, Lu T, Yan Z, Py BF, Ng A, Xavier RJ, Li C, Yankner BA, Scherzer CR, Yuan J. Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 107: 14164-9. PMID 20660724 DOI: 10.1073/Pnas.1009485107  1
2010 Lipinski MM, Hoffman G, Ng A, Zhou W, Py BF, Hsu E, Liu X, Eisenberg J, Liu J, Blenis J, Xavier RJ, Yuan J. A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions. Developmental Cell. 18: 1041-52. PMID 20627085 DOI: 10.1016/J.Devcel.2010.05.005  1
2010 Huang Y, Zhou X, Miao B, Lipinski M, Zhang Y, Li F, Degterev A, Yuan J, Hu G, Wong ST. A computational framework for studying neuron morphology from in vitro high content neuron-based screening. Journal of Neuroscience Methods. 190: 299-309. PMID 20580743 DOI: 10.1016/J.Jneumeth.2010.05.012  1
2010 Furuya T, Kim M, Lipinski M, Li J, Kim D, Lu T, Shen Y, Rameh L, Yankner B, Tsai LH, Yuan J. Negative regulation of Vps34 by Cdk mediated phosphorylation. Molecular Cell. 38: 500-11. PMID 20513426 DOI: 10.1016/J.Molcel.2010.05.009  1
2010 Yao J, Py BF, Zhu H, Bao J, Yuan J. Role of protein misfolding in DFNA9 hearing loss. The Journal of Biological Chemistry. 285: 14909-19. PMID 20228067 DOI: 10.1074/Jbc.M110.106724  1
2010 Christofferson DE, Yuan J. Necroptosis as an alternative form of programmed cell death. Current Opinion in Cell Biology. 22: 263-8. PMID 20045303 DOI: 10.1016/J.Ceb.2009.12.003  1
2010 Rosenbaum DM, Degterev A, David J, Rosenbaum PS, Roth S, Grotta JC, Cuny GD, Yuan J, Savitz SI. Necroptosis, a novel form of caspase-independent cell death, contributes to neuronal damage in a retinal ischemia-reperfusion injury model. Journal of Neuroscience Research. 88: 1569-76. PMID 20025059 DOI: 10.1002/Jnr.22314  1
2010 Xia HG, Zhang L, Chen G, Zhang T, Liu J, Jin M, Ma X, Ma D, Yuan J. Control of basal autophagy by calpain1 mediated cleavage of ATG5. Autophagy. 6: 61-6. PMID 19901552 DOI: 10.4161/Auto.6.1.10326  1
2010 Yi C, Yuan J. Abstract SY31-03: Global signaling mechanisms that regulate autophagy Cellular and Molecular Biology. DOI: 10.1158/1538-7445.Am10-Sy31-03  0.04
2009 Huang Y, Zhou X, Miao B, Lipinski M, Xia Z, Hu G, Degterev A, Yuan J, Wong ST. An Image Based System Biology Approach for Alzheimer's Disease Pathway Analysis. Ieee/Nih Life Science Systems and Applications Workshop. Ieee/Nih Life Science Systems and Applications Workshop. 2009: 128-132. PMID 20585413 DOI: 10.1109/LISSA.2009.4906726  1
2009 Shen S, Zhang P, Lovchik MA, Li Y, Tang L, Chen Z, Zeng R, Ma D, Yuan J, Yu Q. Cyclodepsipeptide toxin promotes the degradation of Hsp90 client proteins through chaperone-mediated autophagy. The Journal of Cell Biology. 185: 629-39. PMID 19433452 DOI: 10.1083/Jcb.200810183  1
2009 Py BF, Boyce M, Yuan J. A critical role of eEF-2K in mediating autophagy in response to multiple cellular stresses. Autophagy. 5: 393-6. PMID 19221463 DOI: 10.4161/Auto.5.3.7762  1
2009 Panaretakis T, Kepp O, Brockmeier U, Tesniere A, Bjorklund AC, Chapman DC, Durchschlag M, Joza N, Pierron G, van Endert P, Yuan J, Zitvogel L, Madeo F, Williams DB, Kroemer G. Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death. The Embo Journal. 28: 578-90. PMID 19165151 DOI: 10.1038/Emboj.2009.1  1
2009 Yi CH, Yuan J. The Jekyll and Hyde functions of caspases. Developmental Cell. 16: 21-34. PMID 19154716 DOI: 10.1016/J.Devcel.2008.12.012  1
2009 Yuan J. Neuroprotective strategies targeting apoptotic and necrotic cell death for stroke. Apoptosis : An International Journal On Programmed Cell Death. 14: 469-77. PMID 19137430 DOI: 10.1007/S10495-008-0304-8  1
2008 Hitomi J, Christofferson DE, Ng A, Yao J, Degterev A, Xavier RJ, Yuan J. Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway. Cell. 135: 1311-23. PMID 19109899 DOI: 10.1016/J.Cell.2008.10.044  1
2008 Ch'en IL, Beisner DR, Degterev A, Lynch C, Yuan J, Hoffmann A, Hedrick SM. Antigen-mediated T cell expansion regulated by parallel pathways of death. Proceedings of the National Academy of Sciences of the United States of America. 105: 17463-8. PMID 18981423 DOI: 10.1073/Pnas.0808043105  1
2008 Li J, Yuan J. Caspases in apoptosis and beyond. Oncogene. 27: 6194-6206. PMID 18931687 DOI: 10.1038/Onc.2008.297  1
2008 Pan H, Yu J, Zhang L, Carpenter A, Zhu H, Li L, Ma D, Yuan J. A novel small molecule regulator of guanine nucleotide exchange activity of the ADP-ribosylation factor and golgi membrane trafficking. The Journal of Biological Chemistry. 283: 31087-96. PMID 18799457 DOI: 10.1074/Jbc.M806592200  1
2008 Zheng W, Degterev A, Hsu E, Yuan J, Yuan C. Structure-activity relationship study of a novel necroptosis inhibitor, necrostatin-7. Bioorganic & Medicinal Chemistry Letters. 18: 4932-5. PMID 18768316 DOI: 10.1016/j.bmcl.2008.08.058  1
2008 Bryant KF, Macari ER, Malik N, Boyce M, Yuan J, Coen DM. ICP34.5-dependent and -independent activities of salubrinal in herpes simplex virus-1 infected cells. Virology. 379: 197-204. PMID 18684481 DOI: 10.1016/J.Virol.2008.06.028  1
2008 Sanchez-Olea R, Ortiz S, Barreto O, Yang Q, Xu CJ, Zhu H, Yuan J. Parcs is a dual regulator of cell proliferation and apaf-1 function. The Journal of Biological Chemistry. 283: 24400-5. PMID 18562310 DOI: 10.1074/Jbc.M804664200  1
2008 You Z, Savitz SI, Yang J, Degterev A, Yuan J, Cuny GD, Moskowitz MA, Whalen MJ. Necrostatin-1 reduces histopathology and improves functional outcome after controlled cortical impact in mice. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 28: 1564-73. PMID 18493258 DOI: 10.1038/Jcbfm.2008.44  1
2008 Teng X, Keys H, Yuan J, Degterev A, Cuny GD. Structure-activity relationship and liver microsome stability studies of pyrrole necroptosis inhibitors. Bioorganic & Medicinal Chemistry Letters. 18: 3219-23. PMID 18467094 DOI: 10.1016/J.Bmcl.2008.04.048  1
2008 Zhu J, Blenis J, Yuan J. Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1. Proceedings of the National Academy of Sciences of the United States of America. 105: 6584-9. PMID 18451027 DOI: 10.1073/Pnas.0802785105  1
2008 Degterev A, Yuan J. Expansion and evolution of cell death programmes. Nature Reviews. Molecular Cell Biology. 9: 378-90. PMID 18414491 DOI: 10.1038/Nrm2393  1
2008 Li J, Yin HL, Yuan J. Flightless-I regulates proinflammatory caspases by selectively modulating intracellular localization and caspase activity. The Journal of Cell Biology. 181: 321-33. PMID 18411310 DOI: 10.1083/Jcb.200711082  1
2008 Degterev A, Hitomi J, Germscheid M, Ch'en IL, Korkina O, Teng X, Abbott D, Cuny GD, Yuan C, Wagner G, Hedrick SM, Gerber SA, Lugovskoy A, Yuan J. Identification of RIP1 kinase as a specific cellular target of necrostatins. Nature Chemical Biology. 4: 313-21. PMID 18408713 DOI: 10.1038/Nchembio.83  1
2008 Oh YK, Shin KS, Yuan J, Kang SJ. Superoxide dismutase 1 mutants related to amyotrophic lateral sclerosis induce endoplasmic stress in neuro2a cells. Journal of Neurochemistry. 104: 993-1005. PMID 18233996 DOI: 10.1111/J.1471-4159.2007.05053.X  1
2008 Twig G, Elorza A, Molina AJ, Mohamed H, Wikstrom JD, Walzer G, Stiles L, Haigh SE, Katz S, Las G, Alroy J, Wu M, Py BF, Yuan J, Deeney JT, et al. Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. The Embo Journal. 27: 433-46. PMID 18200046 DOI: 10.1038/Sj.Emboj.7601963  1
2008 Yuan J. Inducing autophagy harmlessly. Autophagy. 4: 249-50. PMID 18094626 DOI: 10.4161/Auto.5438  1
2008 Cuny GD, Degterev A, Yuan J. Necroptosis - A novel cell death mechanism Drugs of the Future. 33: 225-233. DOI: 10.1358/dof.2008.033.03.1173882  1
2008 Fang Z, Yuan JP, Wang YC, Lo SM. Survey of pedestrian movement and development of a crowd dynamics model Fire Safety Journal. 43: 459-465. DOI: 10.1016/j.firesaf.2007.12.005  1
2007 Steele AD, Hetz C, Yi CH, Jackson WS, Borkowski AW, Yuan J, Wollmann RH, Lindquist S. Prion pathogenesis is independent of caspase-12. Prion. 1: 243-7. PMID 19164919 DOI: 10.4161/Pri.1.4.5551  1
2007 Xu L, Zhu J, Hu X, Zhu H, Kim HT, LaBaer J, Goldberg A, Yuan J. c-IAP1 cooperates with Myc by acting as a ubiquitin ligase for Mad1. Molecular Cell. 28: 914-22. PMID 18082613 DOI: 10.1016/J.Molcel.2007.10.027  1
2007 Sanchez-Olea R, Yuan J. To kill or to arrest: that is the new question for Apaf-1. Molecular Cell. 28: 520-1. PMID 18042448 DOI: 10.1016/J.Molcel.2007.11.007  1
2007 Zhang L, Yu J, Pan H, Hu P, Hao Y, Cai W, Zhu H, Yu AD, Xie X, Ma D, Yuan J. Small molecule regulators of autophagy identified by an image-based high-throughput screen. Proceedings of the National Academy of Sciences of the United States of America. 104: 19023-8. PMID 18024584 DOI: 10.1073/Pnas.0709695104  1
2007 Yi CH, Sogah DK, Boyce M, Degterev A, Christofferson DE, Yuan J. A genome-wide RNAi screen reveals multiple regulators of caspase activation. The Journal of Cell Biology. 179: 619-26. PMID 17998402 DOI: 10.1083/Jcb.200708090  1
2007 Teng X, Keys H, Jeevanandam A, Porco JA, Degterev A, Yuan J, Cuny GD. Structure-activity relationship study of [1,2,3]thiadiazole necroptosis inhibitors. Bioorganic & Medicinal Chemistry Letters. 17: 6836-40. PMID 17964153 DOI: 10.1016/J.Bmcl.2007.10.024  1
2007 Yuan J. Junying Yuan: changing avenues without losing focus. Interview by Nicole LeBrasseur. The Journal of Cell Biology. 179: 174-5. PMID 17954602 DOI: 10.1083/jcb.1792pi  1
2007 Takeda S, Iwai A, Nakashima M, Fujikura D, Chiba S, Li HM, Uehara J, Kawaguchi S, Kaya M, Nagoya S, Wada T, Yuan J, Rayter S, Ashworth A, Reed JC, et al. LKB1 is crucial for TRAIL-mediated apoptosis induction in osteosarcoma. Anticancer Research. 27: 761-8. PMID 17465200  1
2007 Zhang Y, Zhou X, Degterev A, Lipinski M, Adjeroh D, Yuan J, Wong ST. Automated neurite extraction using dynamic programming for high-throughput screening of neuron-based assays. Neuroimage. 35: 1502-15. PMID 17363284 DOI: 10.1016/J.Neuroimage.2007.01.014  1
2007 Jagtap PG, Degterev A, Choi S, Keys H, Yuan J, Cuny GD. Structure-activity relationship study of tricyclic necroptosis inhibitors. Journal of Medicinal Chemistry. 50: 1886-95. PMID 17361994 DOI: 10.1021/Jm061016O  1
2007 Li J, Brieher WM, Scimone ML, Kang SJ, Zhu H, Yin H, von Andrian UH, Mitchison T, Yuan J. Caspase-11 regulates cell migration by promoting Aip1-Cofilin-mediated actin depolymerization. Nature Cell Biology. 9: 276-86. PMID 17293856 DOI: 10.1038/Ncb1541  1
2007 Wang K, Li J, Degterev A, Hsu E, Yuan J, Yuan C. Structure-activity relationship analysis of a novel necroptosis inhibitor, Necrostatin-5. Bioorganic & Medicinal Chemistry Letters. 17: 1455-65. PMID 17270434 DOI: 10.1016/J.Bmcl.2006.11.056  1
2007 Moerke NJ, Aktas H, Chen H, Cantel S, Reibarkh MY, Fahmy A, Gross JD, Degterev A, Yuan J, Chorev M, Halperin JA, Wagner G. Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G. Cell. 128: 257-67. PMID 17254965 DOI: 10.1016/J.Cell.2006.11.046  1
2007 Takai Y, Matikainen T, Jurisicova A, Kim MR, Trbovich AM, Fujita E, Nakagawa T, Lemmers B, Flavell RA, Hakem R, Momoi T, Yuan J, Tilly JL, Perez GI. Caspase-12 compensates for lack of caspase-2 and caspase-3 in female germ cells. Apoptosis : An International Journal On Programmed Cell Death. 12: 791-800. PMID 17245644 DOI: 10.1007/S10495-006-0022-Z  1
2007 Stegh AH, Kim H, Bachoo RM, Forloney KL, Zhang J, Schulze H, Park K, Hannon GJ, Yuan J, Louis DN, DePinho RA, Chin L. Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma. Genes & Development. 21: 98-111. PMID 17210792 DOI: 10.1101/Gad.1480007  1
2007 Py BF, Lipinski MM, Yuan J. Autophagy limits Listeria monocytogenes intracellular growth in the early phase of primary infection. Autophagy. 3: 117-25. PMID 17204850 DOI: 10.4161/Auto.3618  1
2007 Cnop M, Ladriere L, Hekerman P, Ortis F, Cardozo AK, Dogusan Z, Flamez D, Boyce M, Yuan J, Eizirik DL. Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis. The Journal of Biological Chemistry. 282: 3989-97. PMID 17158450 DOI: 10.1074/Jbc.M607627200  1
2007 Zhang Y, Zhou X, Degterev A, Lipinski M, Adjeroh D, Yuan J, Wong ST. A novel tracing algorithm for high throughput imaging Screening of neuron-based assays. Journal of Neuroscience Methods. 160: 149-62. PMID 16987551 DOI: 10.1016/J.Jneumeth.2006.07.028  1
2007 Guo S-, Shen X, Yang J, Yuan J, Yang R-, Mao K, Zhao D-, Li C-. TIMP-1 mediates the inhibitory effect of interleukin-6 on the proliferation of a hepatocarcinoma cell line in a STAT3-dependent manner Brazilian Journal of Medical and Biological Research. 40: 621-631. DOI: 10.1590/S0100-879X2006005000084  1
2006 Yuan J. Divergence from a dedicated cellular suicide mechanism: exploring the evolution of cell death. Molecular Cell. 23: 1-12. PMID 16818228 DOI: 10.1016/J.Molcel.2006.06.008  1
2006 Matsui T, Ramasamy K, Ingelsson M, Fukumoto H, Conrad C, Frosch MP, Irizarry MC, Yuan J, Hyman BT. Coordinated expression of caspase 8, 3 and 7 mRNA in temporal cortex of Alzheimer disease: relationship to formic acid extractable abeta42 levels. Journal of Neuropathology and Experimental Neurology. 65: 508-15. PMID 16772874 DOI: 10.1097/01.Jnen.0000229238.05748.12  1
2006 Shibata M, Lu T, Furuya T, Degterev A, Mizushima N, Yoshimori T, MacDonald M, Yankner B, Yuan J. Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1. The Journal of Biological Chemistry. 281: 14474-85. PMID 16522639 DOI: 10.1074/Jbc.M600364200  1
2006 Yoo LI, Liu DW, Le Vu S, Bronson RT, Wu H, Yuan J. Pten deficiency activates distinct downstream signaling pathways in a tissue-specific manner. Cancer Research. 66: 1929-39. PMID 16488991 DOI: 10.1158/0008-5472.Can-05-1986  1
2006 Boyce M, Yuan J. Cellular response to endoplasmic reticulum stress: A matter of life or death Cell Death and Differentiation. 13: 363-373. PMID 16397583 DOI: 10.1038/Sj.Cdd.4401817  1
2006 Levine B, Yuan J. Erratum: Autophagy in cell death: An innocent convict? (Journal of Clinical Investigation (2005) 115, (2679-2688) DOI:101172/JCI26390) Journal of Clinical Investigation. 116. DOI: 10.1172/Jci26390C1  1
2006 Yuan J. Insights into the regulatory mechanisms in the cellular protein processing factory Cell Death and Differentiation. 13: 359. DOI: 10.1038/Sj.Cdd.4401842  1
2005 Degterev A, Huang Z, Boyce M, Li Y, Jagtap P, Mizushima N, Cuny GD, Mitchison TJ, Moskowitz MA, Yuan J. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nature Chemical Biology. 1: 112-9. PMID 16408008 DOI: 10.1038/Nchembio711  1
2005 Lipinski MM, Yuan J. A cellular response to an internal energy crisis. Cell. 123: 3-5. PMID 16213206 DOI: 10.1016/J.Cell.2005.09.015  1
2005 Levine B, Yuan J. Autophagy in cell death: an innocent convict? The Journal of Clinical Investigation. 115: 2679-88. PMID 16200202 DOI: 10.1172/Jci26390  1
2005 Gozani O, Field SJ, Ferguson CG, Ewalt M, Mahlke C, Cantley LC, Prestwich GD, Yuan J. Modification of protein sub-nuclear localization by synthetic phosphoinositides: evidence for nuclear phosphoinositide signaling mechanisms. Advances in Enzyme Regulation. 45: 171-85. PMID 16199078 DOI: 10.1016/J.Advenzreg.2005.02.010  1
2005 Teng X, Degterev A, Jagtap P, Xing X, Choi S, Denu R, Yuan J, Cuny GD. Structure-activity relationship study of novel necroptosis inhibitors. Bioorganic & Medicinal Chemistry Letters. 15: 5039-44. PMID 16153840 DOI: 10.1016/J.Bmcl.2005.07.077  1
2005 Long K, Boyce M, Lin H, Yuan J, Ma D. Structure-activity relationship studies of salubrinal lead to its active biotinylated derivative. Bioorganic & Medicinal Chemistry Letters. 15: 3849-52. PMID 16002288 DOI: 10.1016/J.Bmcl.2005.05.120  1
2005 Elkin SK, Ivanov D, Ewalt M, Ferguson CG, Hyberts SG, Sun ZY, Prestwich GD, Yuan J, Wagner G, Oettinger MA, Gozani OP. A PHD finger motif in the C terminus of RAG2 modulates recombination activity. The Journal of Biological Chemistry. 280: 28701-10. PMID 15964836 DOI: 10.1074/Jbc.M504731200  1
2005 Boyce M, Bryant KF, Jousse C, Long K, Harding HP, Scheuner D, Kaufman RJ, Ma D, Coen DM, Ron D, Yuan J. A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. Science (New York, N.Y.). 307: 935-9. PMID 15705855 DOI: 10.1126/Science.1101902  1
2005 Gong D, Li J, Yuan C, Yuan J. Synthetic study of substituted arylsulfonylphenylbenzamides Synthetic Communications. 35: 55-66. DOI: 10.1081/Scc-200046496  1
2004 Kang SJ, Popat R, Bragdon C, Odonnell K, Phelan S, Yuan J, Sonis ST. Caspase-11 is not necessary for chemotherapy-induced intestinal mucositis. Dna and Cell Biology. 23: 490-5. PMID 15307951 DOI: 10.1089/1044549041562302  1
2004 Terui Y, Saad N, Jia S, McKeon F, Yuan J. Dual role of sumoylation in the nuclear localization and transcriptional activation of NFAT1. The Journal of Biological Chemistry. 279: 28257-65. PMID 15117942 DOI: 10.1074/Jbc.M403153200  1
2004 Yuan J, Horvitz HR. A first insight into the molecular mechanisms of apoptosis. Cell. 116: S53-6, 1 p following. PMID 15055582 DOI: 10.1016/S0092-8674(04)00028-5  1
2004 Lipinski MM, Yuan J. Mechanisms of cell death in polyglutamine expansion diseases. Current Opinion in Pharmacology. 4: 85-90. PMID 15018844 DOI: 10.1016/J.Coph.2003.09.008  1
2004 Qiu XB, Markant SL, Yuan J, Goldberg AL. Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis. The Embo Journal. 23: 800-10. PMID 14765125 DOI: 10.1038/Sj.Emboj.7600075  1
2004 Boyce M, Degterev A, Yuan J. Caspases: An ancient cellular sword of Damocles Cell Death and Differentiation. 11: 29-37. PMID 14647235 DOI: 10.1038/Sj.Cdd.4401339  1
2004 Kobori M, Yang Z, Gong D, Heissmeyer V, Zhu H, Jung YK, Gakidis MAM, Rao A, Sekine T, Ikegami F, Yuan C, Yuan J. Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK complex Cell Death and Differentiation. 11: 123-130. PMID 14526390 DOI: 10.1038/Sj.Cdd.4401325  1
2003 Degterev A, Boyce M, Yuan J. A decade of caspases. Oncogene. 22: 8543-67. PMID 14634618 DOI: 10.1038/Sj.Onc.1207107  1
2003 Yuan J, Lipinski M, Degterev A. Diversity in the mechanisms of neuronal cell death Neuron. 40: 401-413. PMID 14556717 DOI: 10.1016/S0896-6273(03)00601-9  1
2003 Welch K, Yuan J. Alpha-synuclein oligomerization: a role for lipids? Trends in Neurosciences. 26: 517-9. PMID 14522142 DOI: 10.1016/J.Tins.2003.08.001  1
2003 Gozani O, Karuman P, Jones DR, Ivanov D, Cha J, Lugovskoy AA, Baird CL, Zhu H, Field SJ, Lessnick SL, Villasenor J, Mehrotra B, Chen J, Rao VR, Brugge JS, ... ... Yuan J, et al. The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor. Cell. 114: 99-111. PMID 12859901 DOI: 10.1016/S0092-8674(03)00480-X  1
2003 Zong WX, Li C, Hatzivassiliou G, Lindsten T, Yu QC, Yuan J, Thompson CB. Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis Journal of Cell Biology. 162: 59-69. PMID 12847083 DOI: 10.1083/Jcb.200302084  1
2003 Kang SJ, Sanchez I, Jing N, Yuan J. Dissociation between neurodegeneration and caspase-11-mediated activation of caspase-1 and caspase-3 in a mouse model of amyotrophic lateral sclerosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 5455-60. PMID 12843244 DOI: 10.1523/Jneurosci.23-13-05455.2003  1
2003 Sánchez I, Mahlke C, Yuan J. Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders. Nature. 421: 373-9. PMID 12540902 DOI: 10.1038/Nature01301  1
2003 Takai Y, Canning J, Perez GI, Pru JK, Schlezinger JJ, Sherr DH, Kolesnick RN, Yuan J, Flavell RA, Korsmeyer SJ, Tilly JL. Bax, caspase-2, and caspase-3 are required for ovarian follicle loss caused by 4-vinylcyclohexene diepoxide exposure of female mice in vivo Endocrinology. 144: 69-74. PMID 12488331 DOI: 10.1210/En.2002-220814  1
2002 Le DA, Wu Y, Huang Z, Matsushita K, Plesnila N, Augustinack JC, Hyman BT, Yuan J, Kuida K, Flavell RA, Moskowitz MA. Caspase activation and neuroprotection in caspase-3- deficient mice after in vivo cerebral ischemia and in vitro oxygen glucose deprivation. Proceedings of the National Academy of Sciences of the United States of America. 99: 15188-93. PMID 12415117 DOI: 10.1073/Pnas.232473399  1
2002 Kang SJ, Wang S, Kuida K, Yuan J. Distinct downstream pathways of caspase-11 in regulating apoptosis and cytokine maturation during septic shock response Cell Death and Differentiation. 9: 1115-1125. PMID 12232800 DOI: 10.1038/Sj.Cdd.4401087  1
2002 Yoo LI, Chung DC, Yuan J. LKB1 - A master tumour suppressor of the small intestine and beyond Nature Reviews Cancer. 2: 529-535. PMID 12094239 DOI: 10.1038/Nrc843  1
2002 Gozani O, Boyce M, Yoo L, Karuman P, Yuan J. Life and death in paradise Nature Cell Biology. 4: E159-E162. PMID 12042835 DOI: 10.1038/Ncb0602-E159  1
2002 Welch K, Yuan J. Releasing the nerve cell killers. Nature Medicine. 8: 564-5. PMID 12042803 DOI: 10.1038/Nm0602-564  1
2002 Garden GA, Budd SL, Tsai E, Hanson L, Kaul M, D'Emilia DM, Friedlander RM, Yuan J, Masliah E, Lipton SA. Caspase cascades in human immunodeficiency virus-associated neurodegeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 4015-24. PMID 12019321 DOI: 10.1523/Jneurosci.22-10-04015.2002  1
2002 Qiu J, Whalen MJ, Lowenstein P, Fiskum G, Fahy B, Darwish R, Aarabi B, Yuan J, Moskowitz MA. Upregulation of the Fas receptor death-inducing signaling complex after traumatic brain injury in mice and humans. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 3504-11. PMID 11978827  1
2002 Lugovskoy AA, Degterev AI, Fahmy AF, Zhou P, Gross JD, Yuan J, Wagner G. A novel approach for characterizing protein ligand complexes: molecular basis for specificity of small-molecule Bcl-2 inhibitors. Journal of the American Chemical Society. 124: 1234-40. PMID 11841292 DOI: 10.1021/Ja011239Y  1
2002 Qiu J, Whalen MJ, Lowenstein P, Fiskum G, Fahy B, Darwish R, Aarabi B, Yuan J, Moskowitz MA. Upregulation of the Fas receptor death-inducing signaling complex after traumatic brain injury in mice and humans. The Journal of Neuroscience. 22: 3504-3511. DOI: 10.1523/Jneurosci.22-09-03504.2002  1
2002 Yuan J, Morgan DO. Cell division, growth and death Current Opinion in Cell Biology. 14: 673-675. DOI: 10.1016/S0955-0674(02)00397-6  1
2001 Degterev A, Boyce M, Yuan J. The channel of death Journal of Cell Biology. 155: 695-697. PMID 11724809 DOI: 10.1083/Jcb.200110147  1
2001 Morita Y, Maravei DV, Bergeron L, Wang S, Perez GI, Tsutsumi O, Taketani Y, Asano M, Horai R, Korsmeyer SJ, Iwakura Y, Yuan J, Tilly JL. Caspase-2 deficiency prevents programmed germ cell death resulting from cytokine insufficiency but not meiotic defects caused by loss of ataxia telangiectasia-mutated (Atm) gene function Cell Death and Differentiation. 8: 614-620. PMID 11536012 DOI: 10.1038/Sj.Cdd.4400845  1
2001 Karuman P, Gozani O, Odze RD, Zhou XC, Zhu H, Shaw R, Brien TP, Bozzuto CD, Ooi D, Cantley LC, Yuan J. The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death Molecular Cell. 7: 1307-1319. PMID 11430832 DOI: 10.1016/S1097-2765(01)00258-1  1
2001 Kim KW, Chung HH, Chung CW, Kim IK, Miura M, Wang S, Zhu H, Moon KD, Rha GB, Park JH, Jo DG, Woo HN, Song YH, Kim BJ, Yuan J, et al. Inactivation of farnesyltransferase and geranylgeranyltransferase I by caspase-3: Cleavage of the common α subunit during apoptosis Oncogene. 20: 358-366. PMID 11313965 DOI: 10.1038/Sj.Onc.1204099  1
2001 Sánchez I, Yuan J. A convoluted way to die Neuron. 29: 563-566. PMID 11301016 DOI: 10.1016/S0896-6273(01)00232-X  1
2001 Degterev A, Lugovskoy A, Cardone M, Mulley B, Wagner G, Mitchison T, Yuan J. Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL Nature Cell Biology. 3: 173-182. PMID 11175750 DOI: 10.1038/35055085  1
2001 Hisahara S, Yuan J, Momoi T, Okano H, Miura M. Caspase-11 mediates oligodendrocyte cell death and pathogenesis of autoimmune-mediated demyelination Journal of Experimental Medicine. 193: 111-122. PMID 11136825 DOI: 10.1084/Jem.193.1.111  1
2000 Ruffolo SC, Breckenridge DG, Nguyen M, Goping IS, Gross A, Korsmeyer SJ, Li H, Yuan J, Shore GC. BID-dependent and BID-independent pathways for BAX insertion into mitochondria Cell Death and Differentiation. 7: 1101-1108. PMID 11139284 DOI: 10.1038/Sj.Cdd.4400739  1
2000 Yuan J, Yankner BA. Apoptosis in the nervous system. Nature. 407: 802-9. PMID 11048732 DOI: 10.1038/35037739  1
2000 Jesenberger V, Procyk KJ, Yuan J, Reipert S, Baccarini M. Salmonella-induced caspase-2 activation in macrophages: A novel mechanism in pathogen-mediated apoptosis Journal of Experimental Medicine. 192: 1035-1045. PMID 11015444 DOI: 10.1084/Jem.192.7.1035  1
2000 Ding HF, Lin YL, McGill G, Juo P, Zhu H, Blenis J, Yuan J, Fisher DE. Essential role for caspase-8 in transcription-independent apoptosis triggered by p53. The Journal of Biological Chemistry. 275: 38905-11. PMID 10988287 DOI: 10.1074/Jbc.M004714200  1
2000 Shibata M, Hisahara S, Hara H, Yamawaki T, Fukuuchi Y, Yuan J, Okano H, Miura M. Caspases determine the vulnerability of oligodendrocytes in the ischemic brain Journal of Clinical Investigation. 106: 643-653. PMID 10974017 DOI: 10.1172/Jci10203  1
2000 Miura M, Yuan J. Transient transfection assay of cell death genes Methods in Enzymology. 322: 480-492. PMID 10914041 DOI: 10.1016/S0076-6879(00)22044-2  1
2000 Nakagawa T, Zhu H, Morishima N, Li E, Xu J, Yankner BA, Yuan J. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature. 403: 98-103. PMID 10638761 DOI: 10.1038/47513  1
1999 Fink KB, Andrews LJ, Butler WE, Ona VO, Li M, Bogdanov M, Endres M, Khan SQ, Namura S, Stieg PE, Beal MF, Moskowitz MA, Yuan J, Friedlander RM. Reduction of post-traumatic brain injury and free radical production by inhibition of the caspase-1 cascade. Neuroscience. 94: 1213-8. PMID 10625061 DOI: 10.1016/S0306-4522(99)00345-0  1
1999 Rao VR, Corradetti MN, Chen J, Peng J, Yuan J, Prestwich GD, Brugge JS. Expression cloning of protein targets for 3-phosphorylated phosphoinositides Journal of Biological Chemistry. 274: 37893-37900. PMID 10608855 DOI: 10.1074/Jbc.274.53.37893  1
1999 Yuan J, Yankner BA. Caspase activity sows the seeds of neuronal death. Nature Cell Biology. 1: E44-5. PMID 10559896 DOI: 10.1038/10037  1
1999 Degterev A, Yuan J. A new savior for neurons Nature Neuroscience. 2: 930-932. PMID 10526325 DOI: 10.1038/14712  1
1999 Tang YQ, Yuan J, Ösapay G, Ösapay K, Tran D, Miller CJ, Ouellette AJ, Selsted ME. A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated α-defensins Science. 286: 498-502. PMID 10521339 DOI: 10.1126/Science.286.5439.498  1
1999 Ona VO, Li M, Vonsattel JP, Andrews LJ, Khan SQ, Chung WM, Frey AS, Menon AS, Li XJ, Stieg PE, Yuan J, Penney JB, Young AB, Cha JH, Friedlander RM. Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease. Nature. 399: 263-7. PMID 10353249 DOI: 10.1038/20446  1
1999 Li H, Yuan J. Deciphering the pathways of life and death. Current Opinion in Cell Biology. 11: 261-266. PMID 10209152 DOI: 10.1016/S0955-0674(99)80035-0  1
1999 Sánchez I, Xu CJ, Juo P, Kakizaka A, Blenis J, Yuan J. Caspase-8 is required for cell death induced by expanded polyglutamine repeats. Neuron. 22: 623-33. PMID 10197541 DOI: 10.1016/S0896-6273(00)80716-3  1
1999 Chou JJ, Li H, Salvesen GS, Yuan J, Wagner G. Solution structure of BID, an intracellular amplifier of apoptotic signaling. Cell. 96: 615-24. PMID 10089877 DOI: 10.1016/S0092-8674(00)80572-3  1
1999 Zhou P, Chou J, Sanchez-Olea R, Yuan J, Wagner G. Solution structure of APAF-1 CARD Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb1C15/Pdb  1
1998 Friedlander RM, Yuan J. ICE, neuronal apoptosis and neurodegeneration. Cell Death and Differentiation. 5: 823-31. PMID 10203693 DOI: 10.1038/Sj.Cdd.4400433  1
1998 Juo P, Kuo CJ, Yuan J, Blenis J. Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade. Current Biology : Cb. 8: 1001-8. PMID 9740801 DOI: 10.1016/S0960-9822(07)00420-4  1
1998 Haviv R, Lindenboim L, Yuan J, Stein R. Need For Caspase-2 In Apoptosis Of Growth-Factor-Deprived Pc12 Cells Journal of Neuroscience Research. 52: 491-497. PMID 9632305 DOI: 10.1002/(Sici)1097-4547(19980601)52:5<491::Aid-Jnr1>3.0.Co;2-7  1
1998 Cryns V, Yuan J. Proteases to die for. Genes & Development. 12: 1551-70. PMID 9620844 DOI: 10.1101/Gad.12.11.1551  1
1998 Zhou BB, Li H, Yuan J, Kirschner MW. Caspase-dependent activation of cyclin-dependent kinases during Fas-induced apoptosis in Jurkat cells. Proceedings of the National Academy of Sciences of the United States of America. 95: 6785-90. PMID 9618490 DOI: 10.1073/Pnas.95.12.6785  1
1998 Bergeron L, Perez GI, Macdonald G, Shi L, Sun Y, Jurisicova A, Varmuza S, Latham KE, Flaws JA, Salter JCM, Hara H, Moskowitz MA, Li E, Greenberg A, Tilly JL, ... Yuan J, et al. Defects in regulation of apoptosis in caspase-2-deficient mice Genes and Development. 12: 1304-1314. PMID 9573047 DOI: 10.1101/Gad.12.9.1304  1
1998 Wang S, Miura M, Jung YK, Zhu H, Li E, Yuan J. Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE Cell. 92: 501-509. PMID 9491891 DOI: 10.1016/S0092-8674(00)80943-5  1
1997 Haviv R, Lindenboim L, Li H, Yuan J, Stein R. Need for caspases in apoptosis of trophic factor-deprived PC12 cells Journal of Neuroscience Research. 50: 69-80. PMID 9379495 DOI: 10.1002/(Sici)1097-4547(19971001)50:1<69::Aid-Jnr8>3.0.Co;2-J  1
1997 Cryns VL, Byun Y, Rana A, Mellor H, Lustig KD, Ghanem L, Parker PJ, Kirschner MW, Yuan J. Specific proteolysis of the kinase protein kinase C-related kinase 2 by caspase-3 during apoptosis. Identification by a novel, small pool expression cloning strategy. The Journal of Biological Chemistry. 272: 29449-53. PMID 9368003 DOI: 10.1074/Jbc.272.47.29449  1
1997 Li H, Bergeron L, Cryns V, Pasternack MS, Zhu H, Shi L, Greenberg A, Yuan J. Activation of caspase-2 in apoptosis. The Journal of Biological Chemistry. 272: 21010-7. PMID 9261102 DOI: 10.1074/Jbc.272.34.21010  1
1997 Lustig KD, Stukenberg PT, McGarry TJ, King RW, Cryns VL, Mead PE, Zon LI, Yuan J, Kirschner MW. Small pool expression screening: identification of genes involved in cell cycle control, apoptosis, and early development. Methods in Enzymology. 283: 83-99. PMID 9251013 DOI: 10.1016/S0076-6879(97)83009-1  1
1997 Friedlander RM, Brown RH, Gagliardini V, Wang J, Yuan J. Inhibition of ICE slows ALS in mice. Nature. 388: 31. PMID 9214497 DOI: 10.1038/40299  1
1997 Hara H, Fink K, Endres M, Friedlander RM, Gagliardini V, Yuan J, Moskowitz MA. Attenuation of transient focal cerebral ischemic injury in transgenic mice expressing a mutant ICE inhibitory protein. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 17: 370-5. PMID 9143219 DOI: 10.1097/00004647-199704000-00002  1
1997 Jung YK, Yuan J. Suppression of Interleukin-1β converting enzyme (ICE)-induced apoptosis by SV40 large T antigen Oncogene. 14: 1207-1214. PMID 9121770 DOI: 10.1038/Sj.Onc.1200943  1
1997 Friedlander RM, Gagliardini V, Hara H, Fink KB, Li W, MacDonald G, Fishman MC, Greenberg AH, Moskowitz MA, Yuan J. Expression of a dominant negative mutant of interleukin-1 beta converting enzyme in transgenic mice prevents neuronal cell death induced by trophic factor withdrawal and ischemic brain injury. The Journal of Experimental Medicine. 185: 933-40. PMID 9120399 DOI: 10.1084/Jem.185.5.933  1
1997 Yuan J. Genetic control of cellular suicide Reproductive Toxicology. 11: 377-384. PMID 9100313 DOI: 10.1016/S0890-6238(96)00150-5  1
1997 Yuan J. Transducing signals of life and death Current Opinion in Cell Biology. 9: 247-251. PMID 9069264 DOI: 10.1016/S0955-0674(97)80069-5  1
1997 Hara H, Friedlander RM, Gagliardini V, Ayata C, Fink K, Huang Z, Shimizu-Sasamata M, Yuan J, Moskowitz MA. Inhibition of interleukin 1beta converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage. Proceedings of the National Academy of Sciences of the United States of America. 94: 2007-12. PMID 9050895 DOI: 10.1073/Pnas.94.5.2007  1
1996 Cryns VL, Bergeron L, Zhu H, Li H, Yuan J. Specific cleavage of alpha-fodrin during Fas- and tumor necrosis factor-induced apoptosis is mediated by an interleukin-1beta-converting enzyme/Ced-3 protease distinct from the poly(ADP-ribose) polymerase protease. The Journal of Biological Chemistry. 271: 31277-82. PMID 8940132 DOI: 10.1074/Jbc.271.49.31277  1
1996 Miura M, Yuan J. Regulations of Programmed Cell Death by Interleukin-1β-Converting Enzyme Family of Proteases Advances in Experimental Medicine and Biology. 389: 165-172. PMID 8861007 DOI: 10.1007/978-1-4613-0335-0_20  1
1996 Shi L, Chen G, MacDonald G, Bergeron L, Li H, Miura M, Rotello RJ, Miller DK, Li P, Seshadri T, Yuan J, Greenberg AH. Activation of an interleukin 1 converting enzyme-dependent apoptosis pathway by granzyme B. Proceedings of the National Academy of Sciences of the United States of America. 93: 11002-7. PMID 8855298 DOI: 10.1073/Pnas.93.20.11002  1
1996 Yuan J. Evolutionary conservation of a genetic pathway of programmed cell death Journal of Cellular Biochemistry. 60: 4-11. PMID 8825409 DOI: 10.1002/(Sici)1097-4644(19960101)60:1<4::Aid-Jcb2>3.0.Co;2-1  1
1996 Friedlander RM, Gagliardini V, Rotello RJ, Yuan J. Functional role of interleukin 1 beta (IL-1 beta) in IL-1 beta-converting enzyme-mediated apoptosis. The Journal of Experimental Medicine. 184: 717-24. PMID 8760825 DOI: 10.1084/Jem.184.2.717  1
1996 Wang S, Miura M, Jung Yk, Zhu H, Gagliardini V, Shi L, Greenberg AH, Yuan J. Identification and characterization of Ich-3, a member of the interleukin-1beta converting enzyme (ICE)/Ced-3 family and an upstream regulator of ICE. The Journal of Biological Chemistry. 271: 20580-7. PMID 8702803 DOI: 10.1074/Jbc.271.34.20580  1
1996 Jung YK, Miura M, Yuan J. Suppression of interleukin-1β-converting enzyme-mediated cell death by insulin-like growth factor Journal of Biological Chemistry. 271: 5112-5117. PMID 8617790 DOI: 10.1074/Jbc.271.9.5112  1
1995 Miura M, Friedlander RM, Yuan J. Tumor necrosis factor-induced apoptosis is mediated by a CrmA-sensitive cell death pathway. Proceedings of the National Academy of Sciences of the United States of America. 92: 8318-22. PMID 7667287 DOI: 10.1073/Pnas.92.18.8318  1
1995 Yuan J. Molecular control of life and death Current Opinion in Cell Biology. 7: 211-214. PMID 7612273 DOI: 10.1016/0955-0674(95)80030-1  1
1994 Lutticken C, Lütticken C, Wegenka UM, Yuan J, Buschmann J, Schindler C, Ziemiecki A, Harpur AG, Wilks AF, Yasukawa K, Taga T, Kishimoto T, Barbieri G, Pellegrini S, Sendtner M, et al. Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130 Science. 263: 89-92. PMID 8272872 DOI: 10.1126/SCIENCE.8272872  1
1994 Fernandez PA, Rotello RJ, Rangini Z, Doupe A, Drexler HC, Yuan J. Expression of a specific marker of avian programmed cell death in both apoptosis and necrosis. Proceedings of the National Academy of Sciences of the United States of America. 91: 8641-5. PMID 8078937 DOI: 10.1073/Pnas.91.18.8641  1
1993 Miura M, Zhu H, Rotello R, Hartwieg EA, Yuan J. Induction of apoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3. Cell. 75: 653-60. PMID 8242741 DOI: 10.1016/0092-8674(93)90486-A  1
1993 Yuan J, Shaham S, Ledoux S, Ellis HM, Horvitz HR. The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme. Cell. 75: 641-52. PMID 8242740 DOI: 10.1016/0092-8674(93)90485-9  1
1991 Yuan JY, Finney M, Tsung N, Horvitz HR. Tc4, a Caenorhabditis elegans transposable element with an unusual fold-back structure. Proceedings of the National Academy of Sciences of the United States of America. 88: 3334-8. PMID 1849651 DOI: 10.1073/Pnas.88.8.3334  1
1990 Yuan JY, Horvitz HR. The Caenorhabditis elegans genes ced-3 and ced-4 act cell autonomously to cause programmed cell death. Developmental Biology. 138: 33-41. PMID 2307287 DOI: 10.1016/0012-1606(90)90174-H  1
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