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Junying Yuan, Ph.D - Publications

Harvard Medical School, Boston, MA, United States 
Mechanisms of Programmed Cell Death

122 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Xu D, Zhao H, Jin M, Zhu H, Shan B, Geng J, Dziedzic SA, Amin P, Mifflin L, Naito MG, Najafov A, Xing J, Yan L, Liu J, Qin Y, ... ... Yuan J, et al. Modulating TRADD to restore cellular homeostasis and inhibit apoptosis. Nature. PMID 32968279 DOI: 10.1038/s41586-020-2757-z  0.88
2020 Mifflin L, Ofengeim D, Yuan J. Receptor-interacting protein kinase 1 (RIPK1) as a therapeutic target. Nature Reviews. Drug Discovery. PMID 32669658 DOI: 10.1038/s41573-020-0071-y  0.88
2020 Tan S, Zhao J, Sun Z, Cao S, Niu K, Zhong Y, Wang H, Shi L, Pan H, Hu J, Qian L, Liu N, Yuan J. Hepatocyte-specific TAK1 deficiency drives RIPK1 kinase-dependent inflammation to promote liver fibrosis and hepatocellular carcinoma. Proceedings of the National Academy of Sciences of the United States of America. PMID 32513687 DOI: 10.1073/pnas.2005353117  0.36
2020 Naito MG, Xu D, Amin P, Lee J, Wang H, Li W, Kelliher M, Pasparakis M, Yuan J. Sequential activation of necroptosis and apoptosis cooperates to mediate vascular and neural pathology in stroke. Proceedings of the National Academy of Sciences of the United States of America. PMID 32071228 DOI: 10.1073/pnas.1916427117  0.6
2019 Tao P, Sun J, Wu Z, Wang S, Wang J, Li W, Pan H, Bai R, Zhang J, Wang Y, Lee PY, Ying W, Zhou Q, Hou J, Wang W, ... ... Yuan J, et al. A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1. Nature. PMID 31827280 DOI: 10.1038/s41586-019-1830-y  0.32
2019 Najafov A, Mookhtiar AK, Luu HS, Ordureau A, Pan H, Amin PP, Li Y, Lu Q, Yuan J. TAM Kinases Promote Necroptosis by Regulating Oligomerization of MLKL. Molecular Cell. PMID 31230815 DOI: 10.1016/j.molcel.2019.05.022  0.96
2019 Degterev A, Ofengeim D, Yuan J. Targeting RIPK1 for the treatment of human diseases. Proceedings of the National Academy of Sciences of the United States of America. PMID 31048504 DOI: 10.1073/pnas.1901179116  0.88
2019 Wu Z, Geng Y, Lu X, Shi Y, Wu G, Zhang M, Shan B, Pan H, Yuan J. Chaperone-mediated autophagy is involved in the execution of ferroptosis. Proceedings of the National Academy of Sciences of the United States of America. PMID 30718432 DOI: 10.1073/pnas.1819728116  0.32
2018 Wei R, Xu LW, Liu J, Li Y, Zhang P, Shan B, Lu X, Qian L, Wu Z, Dong K, Zhu H, Pan L, Yuan J, Pan H. Corrigendum: SPATA2 regulates the activation of RIPK1 by modulating linear ubiquitination. Genes & Development. 32: 1591. PMID 30509949 DOI: 10.1101/gad.321075.118  0.96
2018 Yuan J, Amin P, Ofengeim D. Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases. Nature Reviews. Neuroscience. PMID 30467385 DOI: 10.1038/s41583-018-0093-1  0.88
2018 Su Z, Dziedzic SA, Hu D, Barrett VJ, Broekema N, Li W, Qian L, Jia N, Ofengeim D, Najafov A, Zhu H, Knipe DM, Yuan J. ABIN-1 heterozygosity sensitizes to innate immune response in both RIPK1-dependent and RIPK1-independent manner. Cell Death and Differentiation. PMID 30341420 DOI: 10.1038/s41418-018-0215-3  0.88
2018 Xu D, Jin T, Zhu H, Chen H, Ofengeim D, Zou C, Mifflin L, Pan L, Amin P, Li W, Shan B, Naito MG, Meng H, Li Y, Pan H, ... ... Yuan J, et al. TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging. Cell. PMID 30146158 DOI: 10.1016/j.cell.2018.07.041  0.96
2018 Amin P, Florez M, Najafov A, Pan H, Geng J, Ofengeim D, Dziedzic SA, Wang H, Barrett VJ, Ito Y, LaVoie MJ, Yuan J. Regulation of a distinct activated RIPK1 intermediate bridging complex I and complex II in TNFα-mediated apoptosis. Proceedings of the National Academy of Sciences of the United States of America. PMID 29891719 DOI: 10.1073/pnas.1806973115  0.88
2018 Zhu K, Liang W, Ma Z, Xu D, Cao S, Lu X, Liu N, Shan B, Qian L, Yuan J. Necroptosis promotes cell-autonomous activation of proinflammatory cytokine gene expression. Cell Death & Disease. 9: 500. PMID 29703889 DOI: 10.1038/s41419-018-0524-y  0.36
2018 Shan B, Pan H, Najafov A, Yuan J. Necroptosis in development and diseases. Genes & Development. 32: 327-340. PMID 29593066 DOI: 10.1101/gad.312561.118  0.32
2018 Meng H, Liu Z, Li X, Wang H, Jin T, Wu G, Shan B, Christofferson DE, Qi C, Yu Q, Li Y, Yuan J. Death-domain dimerization-mediated activation of RIPK1 controls necroptosis and RIPK1-dependent apoptosis. Proceedings of the National Academy of Sciences of the United States of America. PMID 29440439 DOI: 10.1073/pnas.1722013115  0.96
2018 Li F, Xu D, Wang Y, Zhou Z, Liu J, Hu S, Gong Y, Yuan J, Pan L. Structural insights into the ubiquitin recognition by OPTN (optineurin) and its regulation by TBK1-mediated phosphorylation. Autophagy. 1-14. PMID 29394115 DOI: 10.1080/15548627.2017.1391970  0.32
2018 Ouchida AT, Li Y, Geng J, Najafov A, Ofengeim D, Sun X, Yu Q, Yuan J. Synergistic effect of a novel autophagy inhibitor and Quizartinib enhances cancer cell death. Cell Death & Disease. 9: 138. PMID 29374185 DOI: 10.1038/s41419-017-0170-9  0.96
2017 Dziedzic SA, Su Z, Jean Barrett V, Najafov A, Mookhtiar AK, Amin P, Pan H, Sun L, Zhu H, Ma A, Abbott DW, Yuan J. ABIN-1 regulates RIPK1 activation by linking Met1 ubiquitylation with Lys63 deubiquitylation in TNF-RSC. Nature Cell Biology. PMID 29203883 DOI: 10.1038/s41556-017-0003-1  0.6
2017 Wang H, Meng H, Li X, Zhu K, Dong K, Mookhtiar AK, Wei H, Li Y, Sun SC, Yuan J. PELI1 functions as a dual modulator of necroptosis and apoptosis by regulating ubiquitination of RIPK1 and mRNA levels of c-FLIP. Proceedings of the National Academy of Sciences of the United States of America. PMID 29078411 DOI: 10.1073/pnas.1715742114  0.96
2017 Ofengeim D, Mazzitelli S, Ito Y, DeWitt JP, Mifflin L, Zou C, Das S, Adiconis X, Chen H, Zhu H, Kelliher MA, Levin JZ, Yuan J. RIPK1 mediates a disease-associated microglial response in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 28904096 DOI: 10.1073/pnas.1714175114  0.88
2017 Geng J, Ito Y, Shi L, Amin P, Chu J, Ouchida AT, Mookhtiar AK, Zhao H, Xu D, Shan B, Najafov A, Gao G, Akira S, Yuan J. Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis. Nature Communications. 8: 359. PMID 28842570 DOI: 10.1038/s41467-017-00406-w  0.6
2017 Li Y, Yuan J. Systematic Metrics Depicting Cell Death Kinetics. Cell Chemical Biology. 24: 785-786. PMID 28732200 DOI: 10.1016/j.chembiol.2017.07.006  0.96
2017 Wei R, Xu LW, Liu J, Li Y, Zhang P, Shan B, Lu X, Qian L, Wu Z, Dong K, Zhu H, Pan L, Yuan J, Pan H. SPATA2 regulates the activation of RIPK1 by modulating linear ubiquitination. Genes & Development. PMID 28701375 DOI: 10.1101/gad.299776.117  0.96
2017 Li Y, Qian L, Yuan J. Small molecule probes for cellular death machines. Current Opinion in Chemical Biology. 39: 74-82. PMID 28628894 DOI: 10.1016/j.cbpa.2017.05.007  0.96
2017 Xu D, Liu J, Fu T, Shan B, Qian L, Pan L, Yuan J. USP25 regulates Wnt signaling by controlling the stability of tankyrases. Genes & Development. PMID 28619731 DOI: 10.1101/gad.300889.117  0.36
2017 Ofengeim D, Giagtzoglou N, Huh D, Zou C, Yuan J. Single-Cell RNA Sequencing: Unraveling the Brain One Cell at a Time. Trends in Molecular Medicine. PMID 28501348 DOI: 10.1016/j.molmed.2017.04.006  0.88
2016 Afonso MB, Rodrigues PM, Simão AL, Ofengeim D, Carvalho T, Amaral JD, Gaspar MM, Cortez-Pinto H, Castro RE, Yuan J, Rodrigues CM. Activation of necroptosis in human and experimental cholestasis. Cell Death & Disease. 7: e2390. PMID 27685634 DOI: 10.1038/cddis.2016.280  0.88
2016 Vakifahmetoglu-Norberg H, Kim M, Xia HG, Iwanicki MP, Ofengeim D, Coloff JL, Pan L, Ince TA, Kroemer G, Brugge JS, Yuan J. Corrigendum: Chaperone-mediated autophagy degrades mutant p53. Genes & Development. 30: 870. PMID 27036968 DOI: 10.1101/gad.280453.116  0.88
2016 Xia HG, Najafov A, Geng J, Galan-Acosta L, Han X, Guo Y, Shan B, Zhang Y, Norberg E, Zhang T, Pan L, Liu J, Coloff JL, Ofengeim D, Zhu H, ... ... Yuan J, et al. Correction: Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death. The Journal of Cell Biology. PMID 27002169 DOI: 10.1083/jcb.20150304403082016c  0.88
2015 Xia HG, Najafov A, Geng J, Galan-Acosta L, Han X, Guo Y, Shan B, Zhang Y, Norberg E, Zhang T, Pan L, Liu J, Coloff JL, Ofengeim D, Zhu H, ... ... Yuan J, et al. Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death. The Journal of Cell Biology. 210: 705-16. PMID 26323688 DOI: 10.1084/jem.21210OIA79  0.44
2015 Xu D, Zhang T, Xiao J, Zhu K, Wei R, Wu Z, Meng H, Li Y, Yuan J. Modification of BECN1 by ISG15 plays a crucial role in autophagy regulation by type I IFN/interferon. Autophagy. 11: 617-28. PMID 25906440 DOI: 10.1080/15548627.2015.1023982  0.44
2015 Nah J, Yuan J, Jung YK. Autophagy in Neurodegenerative Diseases: From Mechanism to Therapeutic Approach. Molecules and Cells. 38: 381-389. PMID 25896254 DOI: 10.14348/molcells.2015.0034  0.44
2015 Zhang T, Dong K, Liang W, Xu D, Xia H, Geng J, Najafov A, Liu M, Li Y, Han X, Xiao J, Jin Z, Peng T, Gao Y, Cai Y, ... ... Yuan J, et al. G-protein-coupled receptors regulate autophagy by ZBTB16-mediated ubiquitination and proteasomal degradation of Atg14L. Elife. 4: e06734. PMID 25821988 DOI: 10.7554/eLife.06734  0.44
2015 Najjar M, Suebsuwong C, Ray SS, Thapa RJ, Maki JL, Nogusa S, Shah S, Saleh D, Gough PJ, Bertin J, Yuan J, Balachandran S, Cuny GD, Degterev A. Structure guided design of potent and selective ponatinib-based hybrid inhibitors for RIPK1. Cell Reports. 10: 1850-60. PMID 25801024 DOI: 10.1016/j.celrep.2015.02.052  0.84
2015 Ofengeim D, Ito Y, Najafov A, Zhang Y, Shan B, DeWitt JP, Ye J, Zhang X, Chang A, Vakifahmetoglu-Norberg H, Geng J, Py B, Zhou W, Amin P, Berlink Lima J, ... ... Yuan J, et al. Activation of necroptosis in multiple sclerosis. Cell Reports. 10: 1836-49. PMID 25801023 DOI: 10.1016/j.celrep.2015.02.051  0.84
2015 Xiao J, Zhang T, Xu D, Wang H, Cai Y, Jin T, Liu M, Jin M, Wu K, Yuan J. FBXL20-mediated Vps34 ubiquitination as a p53 controlled checkpoint in regulating autophagy and receptor degradation. Genes & Development. 29: 184-96. PMID 25593308 DOI: 10.1101/gad.252528.114  0.32
2014 Degterev A, Zhou W, Maki JL, Yuan J. Assays for necroptosis and activity of RIP kinases. Methods in Enzymology. 545: 1-33. PMID 25065884 DOI: 10.1016/B978-0-12-801430-1.00001-9  0.84
2014 Py BF, Jin M, Desai BN, Penumaka A, Zhu H, Kober M, Dietrich A, Lipinski MM, Henry T, Clapham DE, Yuan J. Caspase-11 controls interleukin-1β release through degradation of TRPC1. Cell Reports. 6: 1122-8. PMID 24630989 DOI: 10.1016/j.celrep.2014.02.015  0.84
2014 Christofferson DE, Li Y, Yuan J. Control of life-or-death decisions by RIP1 kinase. Annual Review of Physiology. 76: 129-50. PMID 24079414 DOI: 10.1146/annurev-physiol-021113-170259  0.96
2013 Ofengeim D, Yuan J. Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death. Nature Reviews. Molecular Cell Biology. 14: 727-36. PMID 24129419 DOI: 10.1038/nrm3683  0.84
2013 Kam TI, Song S, Gwon Y, Park H, Yan JJ, Im I, Choi JW, Choi TY, Kim J, Song DK, Takai T, Kim YC, Kim KS, Choi SY, Choi S, ... ... Yuan J, et al. FcγRIIb mediates amyloid-β neurotoxicity and memory impairment in Alzheimer's disease. The Journal of Clinical Investigation. 123: 2791-802. PMID 23921129 DOI: 10.1172/JCI66827  0.84
2013 Vakifahmetoglu-Norberg H, Kim M, Xia HG, Iwanicki MP, Ofengeim D, Coloff JL, Pan L, Ince TA, Kroemer G, Brugge JS, Yuan J. Chaperone-mediated autophagy degrades mutant p53. Genes & Development. 27: 1718-30. PMID 23913924 DOI: 10.1101/gad.220897.113  0.84
2013 Wu Z, Li Y, Cai Y, Yuan J, Yuan C. A novel necroptosis inhibitor-necrostatin-21 and its SAR study. Bioorganic & Medicinal Chemistry Letters. 23: 4903-6. PMID 23886688 DOI: 10.1016/j.bmcl.2013.06.073  0.96
2013 Py BF, Gonzalez SF, Long K, Kim MS, Kim YA, Zhu H, Yao J, Degauque N, Villet R, Ymele-Leki P, Gadjeva M, Pier GB, Carroll MC, Yuan J. Cochlin produced by follicular dendritic cells promotes antibacterial innate immunity. Immunity. 38: 1063-72. PMID 23684986 DOI: 10.1016/j.immuni.2013.01.015  0.84
2013 Xie T, Peng W, Liu Y, Yan C, Maki J, Degterev A, Yuan J, Shi Y. Structural basis of RIP1 inhibition by necrostatins. Structure (London, England : 1993). 21: 493-9. PMID 23473668 DOI: 10.1016/j.str.2013.01.016  0.84
2012 Choi S, Keys H, Staples RJ, Yuan J, Degterev A, Cuny GD. Optimization of tricyclic Nec-3 necroptosis inhibitors for in vitro liver microsomal stability. Bioorganic & Medicinal Chemistry Letters. 22: 5685-8. PMID 22832318 DOI: 10.1016/j.bmcl.2012.06.098  0.84
2012 Gu Y, Qi C, Sun X, Ma X, Zhang H, Hu L, Yuan J, Yu Q. Arctigenin preferentially induces tumor cell death under glucose deprivation by inhibiting cellular energy metabolism. Biochemical Pharmacology. 84: 468-76. PMID 22687625 DOI: 10.1016/j.bcp.2012.06.002  0.84
2012 Hyman BT, Yuan J. Apoptotic and non-apoptotic roles of caspases in neuronal physiology and pathophysiology. Nature Reviews. Neuroscience. 13: 395-406. PMID 22595785 DOI: 10.1038/nrn3228  0.84
2012 Ofengeim D, Shi P, Miao B, Fan J, Xia X, Fan Y, Lipinski MM, Hashimoto T, Polydoro M, Yuan J, Wong ST, Degterev A. Identification of small molecule inhibitors of neurite loss induced by Aβ peptide using high content screening. The Journal of Biological Chemistry. 287: 8714-23. PMID 22277654 DOI: 10.1074/jbc.M111.290957  0.84
2011 Liu J, Xia H, Kim M, Xu L, Li Y, Zhang L, Cai Y, Norberg HV, Zhang T, Furuya T, Jin M, Zhu Z, Wang H, Yu J, Li Y, ... ... Yuan J, et al. Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. Cell. 147: 223-34. PMID 21962518 DOI: 10.1016/j.cell.2011.08.037  0.96
2011 Yi CH, Pan H, Seebacher J, Jang IH, Hyberts SG, Heffron GJ, Vander Heiden MG, Yang R, Li F, Locasale JW, Sharfi H, Zhai B, Rodriguez-Mias R, Luithardt H, Cantley LC, ... ... Yuan J, et al. Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival. Cell. 146: 607-20. PMID 21854985 DOI: 10.1016/j.cell.2011.06.050  0.84
2010 Miao B, Skidan I, Yang J, Lugovskoy A, Reibarkh M, Long K, Brazell T, Durugkar KA, Maki J, Ramana CV, Schaffhausen B, Wagner G, Torchilin V, Yuan J, Degterev A. Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains. Proceedings of the National Academy of Sciences of the United States of America. 107: 20126-31. PMID 21041639 DOI: 10.1073/pnas.1004522107  0.84
2010 Lipinski MM, Zheng B, Lu T, Yan Z, Py BF, Ng A, Xavier RJ, Li C, Yankner BA, Scherzer CR, Yuan J. Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 107: 14164-9. PMID 20660724 DOI: 10.1073/pnas.1009485107  0.84
2010 Lipinski MM, Hoffman G, Ng A, Zhou W, Py BF, Hsu E, Liu X, Eisenberg J, Liu J, Blenis J, Xavier RJ, Yuan J. A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions. Developmental Cell. 18: 1041-52. PMID 20627085 DOI: 10.1016/j.devcel.2010.05.005  0.84
2010 Huang Y, Zhou X, Miao B, Lipinski M, Zhang Y, Li F, Degterev A, Yuan J, Hu G, Wong ST. A computational framework for studying neuron morphology from in vitro high content neuron-based screening. Journal of Neuroscience Methods. 190: 299-309. PMID 20580743 DOI: 10.1016/j.jneumeth.2010.05.012  0.4
2010 Furuya T, Kim M, Lipinski M, Li J, Kim D, Lu T, Shen Y, Rameh L, Yankner B, Tsai LH, Yuan J. Negative regulation of Vps34 by Cdk mediated phosphorylation. Molecular Cell. 38: 500-11. PMID 20513426 DOI: 10.1016/j.molcel.2010.05.009  0.84
2010 Christofferson DE, Yuan J. Necroptosis as an alternative form of programmed cell death. Current Opinion in Cell Biology. 22: 263-8. PMID 20045303 DOI: 10.1016/  0.44
2010 Rosenbaum DM, Degterev A, David J, Rosenbaum PS, Roth S, Grotta JC, Cuny GD, Yuan J, Savitz SI. Necroptosis, a novel form of caspase-independent cell death, contributes to neuronal damage in a retinal ischemia-reperfusion injury model. Journal of Neuroscience Research. 88: 1569-76. PMID 20025059 DOI: 10.1002/jnr.22314  0.84
2009 Huang Y, Zhou X, Miao B, Lipinski M, Xia Z, Hu G, Degterev A, Yuan J, Wong ST. An Image Based System Biology Approach for Alzheimer's Disease Pathway Analysis. Ieee/Nih Life Science Systems and Applications Workshop. Ieee/Nih Life Science Systems and Applications Workshop. 2009: 128-132. PMID 20585413 DOI: 10.1109/LISSA.2009.4906726  0.44
2009 Shen S, Zhang P, Lovchik MA, Li Y, Tang L, Chen Z, Zeng R, Ma D, Yuan J, Yu Q. Cyclodepsipeptide toxin promotes the degradation of Hsp90 client proteins through chaperone-mediated autophagy. The Journal of Cell Biology. 185: 629-39. PMID 19433452 DOI: 10.1083/jcb.200810183  0.44
2009 Py BF, Boyce M, Yuan J. A critical role of eEF-2K in mediating autophagy in response to multiple cellular stresses. Autophagy. 5: 393-6. PMID 19221463 DOI: 10.4161/auto.5.3.7762  0.44
2009 Panaretakis T, Kepp O, Brockmeier U, Tesniere A, Bjorklund AC, Chapman DC, Durchschlag M, Joza N, Pierron G, van Endert P, Yuan J, Zitvogel L, Madeo F, Williams DB, Kroemer G. Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death. The Embo Journal. 28: 578-90. PMID 19165151 DOI: 10.1038/emboj.2009.1  0.44
2009 Yi CH, Yuan J. The Jekyll and Hyde functions of caspases. Developmental Cell. 16: 21-34. PMID 19154716 DOI: 10.1016/j.devcel.2008.12.012  0.44
2009 Yuan J. Neuroprotective strategies targeting apoptotic and necrotic cell death for stroke. Apoptosis : An International Journal On Programmed Cell Death. 14: 469-77. PMID 19137430 DOI: 10.1007/s10495-008-0304-8  0.44
2008 Hitomi J, Christofferson DE, Ng A, Yao J, Degterev A, Xavier RJ, Yuan J. Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway. Cell. 135: 1311-23. PMID 19109899 DOI: 10.1016/j.cell.2008.10.044  0.44
2008 Ch'en IL, Beisner DR, Degterev A, Lynch C, Yuan J, Hoffmann A, Hedrick SM. Antigen-mediated T cell expansion regulated by parallel pathways of death. Proceedings of the National Academy of Sciences of the United States of America. 105: 17463-8. PMID 18981423 DOI: 10.1073/pnas.0808043105  0.44
2008 Pan H, Yu J, Zhang L, Carpenter A, Zhu H, Li L, Ma D, Yuan J. A novel small molecule regulator of guanine nucleotide exchange activity of the ADP-ribosylation factor and golgi membrane trafficking. The Journal of Biological Chemistry. 283: 31087-96. PMID 18799457 DOI: 10.1074/jbc.M806592200  0.44
2008 Zheng W, Degterev A, Hsu E, Yuan J, Yuan C. Structure-activity relationship study of a novel necroptosis inhibitor, necrostatin-7. Bioorganic & Medicinal Chemistry Letters. 18: 4932-5. PMID 18768316 DOI: 10.1016/j.bmcl.2008.08.058  0.44
2008 Bryant KF, Macari ER, Malik N, Boyce M, Yuan J, Coen DM. ICP34.5-dependent and -independent activities of salubrinal in herpes simplex virus-1 infected cells. Virology. 379: 197-204. PMID 18684481 DOI: 10.1016/j.virol.2008.06.028  0.44
2008 Sanchez-Olea R, Ortiz S, Barreto O, Yang Q, Xu CJ, Zhu H, Yuan J. Parcs is a dual regulator of cell proliferation and apaf-1 function. The Journal of Biological Chemistry. 283: 24400-5. PMID 18562310 DOI: 10.1074/jbc.M804664200  0.44
2008 You Z, Savitz SI, Yang J, Degterev A, Yuan J, Cuny GD, Moskowitz MA, Whalen MJ. Necrostatin-1 reduces histopathology and improves functional outcome after controlled cortical impact in mice. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 28: 1564-73. PMID 18493258 DOI: 10.1038/jcbfm.2008.44  0.44
2008 Teng X, Keys H, Yuan J, Degterev A, Cuny GD. Structure-activity relationship and liver microsome stability studies of pyrrole necroptosis inhibitors. Bioorganic & Medicinal Chemistry Letters. 18: 3219-23. PMID 18467094 DOI: 10.1016/j.bmcl.2008.04.048  0.44
2008 Zhu J, Blenis J, Yuan J. Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1. Proceedings of the National Academy of Sciences of the United States of America. 105: 6584-9. PMID 18451027 DOI: 10.1073/pnas.0802785105  0.44
2008 Degterev A, Yuan J. Expansion and evolution of cell death programmes. Nature Reviews. Molecular Cell Biology. 9: 378-90. PMID 18414491 DOI: 10.1038/nrm2393  0.44
2008 Li J, Yin HL, Yuan J. Flightless-I regulates proinflammatory caspases by selectively modulating intracellular localization and caspase activity. The Journal of Cell Biology. 181: 321-33. PMID 18411310 DOI: 10.1083/jcb.200711082  0.44
2008 Degterev A, Hitomi J, Germscheid M, Ch'en IL, Korkina O, Teng X, Abbott D, Cuny GD, Yuan C, Wagner G, Hedrick SM, Gerber SA, Lugovskoy A, Yuan J. Identification of RIP1 kinase as a specific cellular target of necrostatins. Nature Chemical Biology. 4: 313-21. PMID 18408713 DOI: 10.1038/nchembio.83  0.44
2008 Oh YK, Shin KS, Yuan J, Kang SJ. Superoxide dismutase 1 mutants related to amyotrophic lateral sclerosis induce endoplasmic stress in neuro2a cells. Journal of Neurochemistry. 104: 993-1005. PMID 18233996 DOI: 10.1111/j.1471-4159.2007.05053.x  0.44
2008 Twig G, Elorza A, Molina AJ, Mohamed H, Wikstrom JD, Walzer G, Stiles L, Haigh SE, Katz S, Las G, Alroy J, Wu M, Py BF, Yuan J, Deeney JT, et al. Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. The Embo Journal. 27: 433-46. PMID 18200046 DOI: 10.1038/sj.emboj.7601963  0.44
2008 Yuan J. Inducing autophagy harmlessly. Autophagy. 4: 249-50. PMID 18094626  0.44
2007 Steele AD, Hetz C, Yi CH, Jackson WS, Borkowski AW, Yuan J, Wollmann RH, Lindquist S. Prion pathogenesis is independent of caspase-12. Prion. 1: 243-7. PMID 19164919  0.44
2007 Xu L, Zhu J, Hu X, Zhu H, Kim HT, LaBaer J, Goldberg A, Yuan J. c-IAP1 cooperates with Myc by acting as a ubiquitin ligase for Mad1. Molecular Cell. 28: 914-22. PMID 18082613 DOI: 10.1016/j.molcel.2007.10.027  0.44
2007 Sanchez-Olea R, Yuan J. To kill or to arrest: that is the new question for Apaf-1. Molecular Cell. 28: 520-1. PMID 18042448 DOI: 10.1016/j.molcel.2007.11.007  0.44
2007 Zhang L, Yu J, Pan H, Hu P, Hao Y, Cai W, Zhu H, Yu AD, Xie X, Ma D, Yuan J. Small molecule regulators of autophagy identified by an image-based high-throughput screen. Proceedings of the National Academy of Sciences of the United States of America. 104: 19023-8. PMID 18024584 DOI: 10.1073/pnas.0709695104  0.44
2007 Yi CH, Sogah DK, Boyce M, Degterev A, Christofferson DE, Yuan J. A genome-wide RNAi screen reveals multiple regulators of caspase activation. The Journal of Cell Biology. 179: 619-26. PMID 17998402 DOI: 10.1083/jcb.200708090  0.44
2007 Teng X, Keys H, Jeevanandam A, Porco JA, Degterev A, Yuan J, Cuny GD. Structure-activity relationship study of [1,2,3]thiadiazole necroptosis inhibitors. Bioorganic & Medicinal Chemistry Letters. 17: 6836-40. PMID 17964153 DOI: 10.1016/j.bmcl.2007.10.024  0.44
2007 Takeda S, Iwai A, Nakashima M, Fujikura D, Chiba S, Li HM, Uehara J, Kawaguchi S, Kaya M, Nagoya S, Wada T, Yuan J, Rayter S, Ashworth A, Reed JC, et al. LKB1 is crucial for TRAIL-mediated apoptosis induction in osteosarcoma. Anticancer Research. 27: 761-8. PMID 17465200  0.44
2007 Zhang Y, Zhou X, Degterev A, Lipinski M, Adjeroh D, Yuan J, Wong ST. Automated neurite extraction using dynamic programming for high-throughput screening of neuron-based assays. Neuroimage. 35: 1502-15. PMID 17363284 DOI: 10.1016/j.neuroimage.2007.01.014  0.44
2007 Jagtap PG, Degterev A, Choi S, Keys H, Yuan J, Cuny GD. Structure-activity relationship study of tricyclic necroptosis inhibitors. Journal of Medicinal Chemistry. 50: 1886-95. PMID 17361994 DOI: 10.1021/jm061016o  0.44
2007 Li J, Brieher WM, Scimone ML, Kang SJ, Zhu H, Yin H, von Andrian UH, Mitchison T, Yuan J. Caspase-11 regulates cell migration by promoting Aip1-Cofilin-mediated actin depolymerization. Nature Cell Biology. 9: 276-86. PMID 17293856 DOI: 10.1038/ncb1541  0.44
2007 Wang K, Li J, Degterev A, Hsu E, Yuan J, Yuan C. Structure-activity relationship analysis of a novel necroptosis inhibitor, Necrostatin-5. Bioorganic & Medicinal Chemistry Letters. 17: 1455-65. PMID 17270434 DOI: 10.1016/j.bmcl.2006.11.056  0.44
2007 Moerke NJ, Aktas H, Chen H, Cantel S, Reibarkh MY, Fahmy A, Gross JD, Degterev A, Yuan J, Chorev M, Halperin JA, Wagner G. Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G. Cell. 128: 257-67. PMID 17254965 DOI: 10.1016/j.cell.2006.11.046  0.44
2007 Stegh AH, Kim H, Bachoo RM, Forloney KL, Zhang J, Schulze H, Park K, Hannon GJ, Yuan J, Louis DN, DePinho RA, Chin L. Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma. Genes & Development. 21: 98-111. PMID 17210792 DOI: 10.1101/gad.1480007  0.44
2007 Py BF, Lipinski MM, Yuan J. Autophagy limits Listeria monocytogenes intracellular growth in the early phase of primary infection. Autophagy. 3: 117-25. PMID 17204850  0.44
2007 Cnop M, Ladriere L, Hekerman P, Ortis F, Cardozo AK, Dogusan Z, Flamez D, Boyce M, Yuan J, Eizirik DL. Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis. The Journal of Biological Chemistry. 282: 3989-97. PMID 17158450 DOI: 10.1074/jbc.M607627200  0.44
2007 Zhang Y, Zhou X, Degterev A, Lipinski M, Adjeroh D, Yuan J, Wong ST. A novel tracing algorithm for high throughput imaging Screening of neuron-based assays. Journal of Neuroscience Methods. 160: 149-62. PMID 16987551 DOI: 10.1016/j.jneumeth.2006.07.028  0.44
2006 Yuan J. Divergence from a dedicated cellular suicide mechanism: exploring the evolution of cell death. Molecular Cell. 23: 1-12. PMID 16818228 DOI: 10.1016/j.molcel.2006.06.008  0.44
2006 Matsui T, Ramasamy K, Ingelsson M, Fukumoto H, Conrad C, Frosch MP, Irizarry MC, Yuan J, Hyman BT. Coordinated expression of caspase 8, 3 and 7 mRNA in temporal cortex of Alzheimer disease: relationship to formic acid extractable abeta42 levels. Journal of Neuropathology and Experimental Neurology. 65: 508-15. PMID 16772874 DOI: 10.1097/01.jnen.0000229238.05748.12  0.44
2006 Shibata M, Lu T, Furuya T, Degterev A, Mizushima N, Yoshimori T, MacDonald M, Yankner B, Yuan J. Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1. The Journal of Biological Chemistry. 281: 14474-85. PMID 16522639 DOI: 10.1074/jbc.M600364200  0.44
2006 Yoo LI, Liu DW, Le Vu S, Bronson RT, Wu H, Yuan J. Pten deficiency activates distinct downstream signaling pathways in a tissue-specific manner. Cancer Research. 66: 1929-39. PMID 16488991 DOI: 10.1158/0008-5472.CAN-05-1986  0.44
2005 Degterev A, Huang Z, Boyce M, Li Y, Jagtap P, Mizushima N, Cuny GD, Mitchison TJ, Moskowitz MA, Yuan J. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nature Chemical Biology. 1: 112-9. PMID 16408008 DOI: 10.1038/nchembio711  0.44
2005 Lipinski MM, Yuan J. A cellular response to an internal energy crisis. Cell. 123: 3-5. PMID 16213206 DOI: 10.1016/j.cell.2005.09.015  0.44
2005 Levine B, Yuan J. Autophagy in cell death: an innocent convict? The Journal of Clinical Investigation. 115: 2679-88. PMID 16200202 DOI: 10.1172/JCI26390  0.44
2005 Gozani O, Field SJ, Ferguson CG, Ewalt M, Mahlke C, Cantley LC, Prestwich GD, Yuan J. Modification of protein sub-nuclear localization by synthetic phosphoinositides: evidence for nuclear phosphoinositide signaling mechanisms. Advances in Enzyme Regulation. 45: 171-85. PMID 16199078 DOI: 10.1016/j.advenzreg.2005.02.010  0.44
2005 Teng X, Degterev A, Jagtap P, Xing X, Choi S, Denu R, Yuan J, Cuny GD. Structure-activity relationship study of novel necroptosis inhibitors. Bioorganic & Medicinal Chemistry Letters. 15: 5039-44. PMID 16153840 DOI: 10.1016/j.bmcl.2005.07.077  0.44
2005 Long K, Boyce M, Lin H, Yuan J, Ma D. Structure-activity relationship studies of salubrinal lead to its active biotinylated derivative. Bioorganic & Medicinal Chemistry Letters. 15: 3849-52. PMID 16002288 DOI: 10.1016/j.bmcl.2005.05.120  0.44
2005 Elkin SK, Ivanov D, Ewalt M, Ferguson CG, Hyberts SG, Sun ZY, Prestwich GD, Yuan J, Wagner G, Oettinger MA, Gozani OP. A PHD finger motif in the C terminus of RAG2 modulates recombination activity. The Journal of Biological Chemistry. 280: 28701-10. PMID 15964836 DOI: 10.1074/jbc.M504731200  0.44
2005 Boyce M, Bryant KF, Jousse C, Long K, Harding HP, Scheuner D, Kaufman RJ, Ma D, Coen DM, Ron D, Yuan J. A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. Science (New York, N.Y.). 307: 935-9. PMID 15705855 DOI: 10.1126/science.1101902  0.44
2004 Kang SJ, Popat R, Bragdon C, Odonnell K, Phelan S, Yuan J, Sonis ST. Caspase-11 is not necessary for chemotherapy-induced intestinal mucositis. Dna and Cell Biology. 23: 490-5. PMID 15307951 DOI: 10.1089/1044549041562302  0.44
2004 Terui Y, Saad N, Jia S, McKeon F, Yuan J. Dual role of sumoylation in the nuclear localization and transcriptional activation of NFAT1. The Journal of Biological Chemistry. 279: 28257-65. PMID 15117942 DOI: 10.1074/jbc.M403153200  0.44
2004 Yuan J, Horvitz HR. A first insight into the molecular mechanisms of apoptosis. Cell. 116: S53-6, 1 p following. PMID 15055582  1
2004 Lipinski MM, Yuan J. Mechanisms of cell death in polyglutamine expansion diseases. Current Opinion in Pharmacology. 4: 85-90. PMID 15018844 DOI: 10.1016/j.coph.2003.09.008  0.44
2003 Yuan J, Lipinski M, Degterev A. Diversity in the mechanisms of neuronal cell death Neuron. 40: 401-413. PMID 14556717 DOI: 10.1016/S0896-6273(03)00601-9  0.44
2003 Gozani O, Karuman P, Jones DR, Ivanov D, Cha J, Lugovskoy AA, Baird CL, Zhu H, Field SJ, Lessnick SL, Villasenor J, Mehrotra B, Chen J, Rao VR, Brugge JS, ... ... Yuan J, et al. The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor. Cell. 114: 99-111. PMID 12859901 DOI: 10.1016/S0092-8674(03)00480-X  0.44
2003 Zong WX, Li C, Hatzivassiliou G, Lindsten T, Yu QC, Yuan J, Thompson CB. Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis Journal of Cell Biology. 162: 59-69. PMID 12847083 DOI: 10.1083/jcb.200302084  0.44
2003 Kang SJ, Sanchez I, Jing N, Yuan J. Dissociation between neurodegeneration and caspase-11-mediated activation of caspase-1 and caspase-3 in a mouse model of amyotrophic lateral sclerosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 5455-60. PMID 12843244  0.44
2003 Sánchez I, Mahlke C, Yuan J. Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders. Nature. 421: 373-9. PMID 12540902 DOI: 10.1038/nature01301  0.44
2003 Takai Y, Canning J, Perez GI, Pru JK, Schlezinger JJ, Sherr DH, Kolesnick RN, Yuan J, Flavell RA, Korsmeyer SJ, Tilly JL. Bax, caspase-2, and caspase-3 are required for ovarian follicle loss caused by 4-vinylcyclohexene diepoxide exposure of female mice in vivo Endocrinology. 144: 69-74. PMID 12488331 DOI: 10.1210/en.2002-220814  0.44
2002 Le DA, Wu Y, Huang Z, Matsushita K, Plesnila N, Augustinack JC, Hyman BT, Yuan J, Kuida K, Flavell RA, Moskowitz MA. Caspase activation and neuroprotection in caspase-3- deficient mice after in vivo cerebral ischemia and in vitro oxygen glucose deprivation. Proceedings of the National Academy of Sciences of the United States of America. 99: 15188-93. PMID 12415117 DOI: 10.1073/pnas.232473399  0.44
2002 Welch K, Yuan J. Releasing the nerve cell killers. Nature Medicine. 8: 564-5. PMID 12042803 DOI: 10.1038/nm0602-564  0.44
2002 Garden GA, Budd SL, Tsai E, Hanson L, Kaul M, D'Emilia DM, Friedlander RM, Yuan J, Masliah E, Lipton SA. Caspase cascades in human immunodeficiency virus-associated neurodegeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 4015-24. PMID 12019321  0.44
2002 Lugovskoy AA, Degterev AI, Fahmy AF, Zhou P, Gross JD, Yuan J, Wagner G. A novel approach for characterizing protein ligand complexes: molecular basis for specificity of small-molecule Bcl-2 inhibitors. Journal of the American Chemical Society. 124: 1234-40. PMID 11841292 DOI: 10.1021/ja011239y  0.44
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