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Geraldine Seydoux - Publications

Affiliations: 
Johns Hopkins University, Baltimore, MD 
Website:
http://www.bs.jhmi.edu/MBG/SeydouxLab/

76 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Cassani M, Seydoux G. Specialized germline P-bodies are required to specify germ cell fate in C. elegans embryos. Development (Cambridge, England). PMID 36196602 DOI: 10.1242/dev.200920  0.381
2021 Schmidt H, Putnam A, Rasoloson D, Seydoux G. Protein-based condensation mechanisms drive the assembly of RNA-rich P granules. Elife. 10. PMID 34106046 DOI: 10.7554/eLife.63698  0.306
2020 Lee CS, Putnam A, Lu T, He S, Ouyang JPT, Seydoux G. Recruitment of mRNAs to P granules by condensation with intrinsically-disordered proteins. Elife. 9. PMID 31975687 DOI: 10.7554/Elife.52896  0.391
2020 Lee CS, Putnam A, Lu T, He S, Ouyang JPT, Seydoux G. Author response: Recruitment of mRNAs to P granules by condensation with intrinsically-disordered proteins Elife. DOI: 10.7554/Elife.52896.Sa2  0.318
2019 Ouyang JPT, Folkmann A, Bernard L, Lee CY, Seroussi U, Charlesworth AG, Claycomb JM, Seydoux G. P Granules Protect RNA Interference Genes from Silencing by piRNAs. Developmental Cell. PMID 31402283 DOI: 10.1016/J.Devcel.2019.07.026  0.372
2019 Cable J, Brangwynne C, Seydoux G, Cowburn D, Pappu RV, Castañeda CA, Berchowitz LE, Chen Z, Jonikas M, Dernburg A, Mittag T, Fawzi NL. Phase separation in biology and disease-a symposium report. Annals of the New York Academy of Sciences. PMID 31199001 DOI: 10.1111/Nyas.14126  0.34
2019 Putnam A, Cassani M, Smith J, Seydoux G. A gel phase promotes condensation of liquid P granules in Caenorhabditis elegans embryos. Nature Structural & Molecular Biology. PMID 30833787 DOI: 10.1038/S41594-019-0193-2  0.35
2019 Folkmann AW, Seydoux G. Spatial regulation of the polarity kinase PAR-1 by parallel inhibitory mechanisms. Development (Cambridge, England). PMID 30814118 DOI: 10.1242/Dev.171116  0.435
2018 Folkmann AW, Seydoux G. Single-molecule study reveals the frenetic lives of proteins in gradients. Proceedings of the National Academy of Sciences of the United States of America. 115: 9336-9338. PMID 30181287 DOI: 10.1073/Pnas.1812248115  0.433
2018 Seydoux G. The P Granules of C. elegans: A Genetic Model for the Study of RNA-Protein Condensates. Journal of Molecular Biology. PMID 30096346 DOI: 10.1016/j.jmb.2018.08.007  0.303
2018 Seydoux G. The P Granules of C. elegans: A Genetic Model for the Study of RNA-Protein Condensates. Journal of Molecular Biology. PMID 30096346 DOI: 10.1016/J.Jmb.2018.08.007  0.417
2017 Paix A, Folkmann A, Goldman DH, Kulaga H, Grzelak MJ, Rasoloson D, Paidemarry S, Green R, Reed RR, Seydoux G. Precision genome editing using synthesis-dependent repair of Cas9-induced DNA breaks. Proceedings of the National Academy of Sciences of the United States of America. 114: E10745-E10754. PMID 29183983 DOI: 10.1073/Pnas.1711979114  0.303
2017 Lee CS, Lu T, Seydoux G. Nanos promotes epigenetic reprograming of the germline by down-regulation of the THAP transcription factor LIN-15B. Elife. 6. PMID 29111977 DOI: 10.7554/Elife.30201  0.415
2017 Mok CA, Au V, Thompson OA, Edgley ML, Gevirtzman L, Yochem J, Lowry J, Memar N, Wallenfang MR, Rasoloson D, Bowerman B, Schnabel R, Seydoux G, Moerman DG, Waterston RH. MIP-MAP: High Throughput Mapping of Caenorhabditis elegans Temperature-Sensitive Mutants via Molecular Inversion Probes. Genetics. PMID 28827289 DOI: 10.1534/Genetics.117.300179  0.743
2017 Paix A, Folkmann A, Seydoux G. Precision genome editing using CRISPR-Cas9 and linear repair templates in C. elegans. Methods (San Diego, Calif.). PMID 28392263 DOI: 10.1016/J.Ymeth.2017.03.023  0.301
2016 Smith J, Calidas D, Schmidt H, Lu T, Rasoloson D, Seydoux G. Spatial patterning of P granules by RNA-induced phase separation of the intrinsically-disordered protein MEG-3. Elife. 5. PMID 27914198 DOI: 10.7554/Elife.21337  0.366
2016 Smith J, Calidas D, Schmidt H, Lu T, Rasoloson D, Seydoux G. Author response: Spatial patterning of P granules by RNA-induced phase separation of the intrinsically-disordered protein MEG-3 Elife. DOI: 10.7554/Elife.21337.016  0.313
2015 Paix A, Folkmann A, Rasoloson D, Seydoux G. High Efficiency, Homology-Directed Genome Editing in Caenorhabditis elegans Using CRISPR-Cas9 Ribonucleoprotein Complexes. Genetics. 201: 47-54. PMID 26187122 DOI: 10.1534/Genetics.115.179382  0.35
2014 Wang JT, Smith J, Chen BC, Schmidt H, Rasoloson D, Paix A, Lambrus BG, Calidas D, Betzig E, Seydoux G. Regulation of RNA granule dynamics by phosphorylation of serine-rich, intrinsically disordered proteins in C. elegans. Elife. 3: e04591. PMID 25535836 DOI: 10.7554/Elife.04591  0.449
2014 Paix A, Wang Y, Smith HE, Lee CY, Calidas D, Lu T, Smith J, Schmidt H, Krause MW, Seydoux G. Scalable and versatile genome editing using linear DNAs with microhomology to Cas9 Sites in Caenorhabditis elegans. Genetics. 198: 1347-56. PMID 25249454 DOI: 10.1534/Genetics.114.170423  0.33
2014 Wang Y, Wang JT, Rasoloson D, Stitzel ML, O' Connell KF, Smith HE, Seydoux G. Identification of suppressors of mbk-2/DYRK by whole-genome sequencing. G3 (Bethesda, Md.). 4: 231-41. PMID 24347622 DOI: 10.1534/G3.113.009126  0.672
2014 Wang JT, Smith J, Chen B, Schmidt H, Rasoloson D, Paix A, Lambrus BG, Calidas D, Betzig E, Seydoux G. Author response: Regulation of RNA granule dynamics by phosphorylation of serine-rich, intrinsically disordered proteins in C. elegans Elife. DOI: 10.7554/Elife.04591.031  0.394
2013 Motegi F, Seydoux G. The PAR network: redundancy and robustness in a symmetry-breaking system. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 368: 20130010. PMID 24062581 DOI: 10.1098/Rstb.2013.0010  0.414
2013 Seydoux G. 'Goldilocks' suppressor screen identifies web of polarity regulators. Nature Cell Biology. 15: 9-10. PMID 23263368 DOI: 10.1038/Ncb2666  0.317
2013 Wang JT, Seydoux G. Germ cell specification. Advances in Experimental Medicine and Biology. 757: 17-39. PMID 22872473 DOI: 10.1007/978-1-4614-4015-4_2  0.454
2012 Voronina E, Paix A, Seydoux G. The P granule component PGL-1 promotes the localization and silencing activity of the PUF protein FBF-2 in germline stem cells. Development (Cambridge, England). 139: 3732-40. PMID 22991439 DOI: 10.1242/Dev.083980  0.409
2011 Motegi F, Zonies S, Hao Y, Cuenca AA, Griffin E, Seydoux G. Microtubules induce self-organization of polarized PAR domains in Caenorhabditis elegans zygotes. Nature Cell Biology. 13: 1361-7. PMID 21983565 DOI: 10.1038/Ncb2354  0.778
2011 Griffin EE, Odde DJ, Seydoux G. Regulation of the MEX-5 gradient by a spatially segregated kinase/phosphatase cycle. Cell. 146: 955-68. PMID 21925318 DOI: 10.1016/J.Cell.2011.08.012  0.42
2011 Voronina E, Seydoux G, Sassone-Corsi P, Nagamori I. RNA granules in germ cells. Cold Spring Harbor Perspectives in Biology. 3. PMID 21768607 DOI: 10.1101/Cshperspect.A002774  0.421
2010 Gallo CM, Wang JT, Motegi F, Seydoux G. Cytoplasmic partitioning of P granule components is not required to specify the germline in C. elegans. Science (New York, N.Y.). 330: 1685-9. PMID 21127218 DOI: 10.1126/Science.1193697  0.382
2010 Merritt C, Seydoux G. The Puf RNA-binding proteins FBF-1 and FBF-2 inhibit the expression of synaptonemal complex proteins in germline stem cells. Development (Cambridge, England). 137: 1787-98. PMID 20431119 DOI: 10.1242/Dev.050799  0.679
2010 Zonies S, Motegi F, Hao Y, Seydoux G. Symmetry breaking and polarization of the C. elegans zygote by the polarity protein PAR-2. Development (Cambridge, England). 137: 1669-77. PMID 20392744 DOI: 10.1242/Dev.045823  0.767
2010 Voronina E, Seydoux G. The C. elegans homolog of nucleoporin Nup98 is required for the integrity and function of germline P granules. Development (Cambridge, England). 137: 1441-50. PMID 20335358 DOI: 10.1242/Dev.047654  0.386
2010 Merritt C, Seydoux G. Transgenic solutions for the germline. Wormbook : the Online Review of C. Elegans Biology. 1-21. PMID 20169625 DOI: 10.1895/Wormbook.1.148.1  0.564
2009 Cheng KC, Klancer R, Singson A, Seydoux G. Regulation of MBK-2/DYRK by CDK-1 and the pseudophosphatases EGG-4 and EGG-5 during the oocyte-to-embryo transition. Cell. 139: 560-72. PMID 19879842 DOI: 10.1016/J.Cell.2009.08.047  0.462
2008 Nakamura A, Seydoux G. Less is more: specification of the germline by transcriptional repression. Development (Cambridge, England). 135: 3817-27. PMID 18997110 DOI: 10.1242/Dev.022434  0.404
2008 Merritt C, Rasoloson D, Ko D, Seydoux G. 3' UTRs are the primary regulators of gene expression in the C. elegans germline. Current Biology : Cb. 18: 1476-82. PMID 18818082 DOI: 10.1016/J.Cub.2008.08.013  0.675
2008 Gallo CM, Munro E, Rasoloson D, Merritt C, Seydoux G. Processing bodies and germ granules are distinct RNA granules that interact in C. elegans embryos. Developmental Biology. 323: 76-87. PMID 18692039 DOI: 10.1016/J.Ydbio.2008.07.008  0.637
2008 Ghosh D, Seydoux G. Inhibition of transcription by the Caenorhabditis elegans germline protein PIE-1: genetic evidence for distinct mechanisms targeting initiation and elongation. Genetics. 178: 235-43. PMID 18202370 DOI: 10.1534/Genetics.107.083212  0.452
2007 Lee MH, Hook B, Pan G, Kershner AM, Merritt C, Seydoux G, Thomson JA, Wickens M, Kimble J. Conserved regulation of MAP kinase expression by PUF RNA-binding proteins. Plos Genetics. 3: e233. PMID 18166083 DOI: 10.1371/Journal.Pgen.0030233  0.674
2007 Motegi F, Seydoux G. Revisiting the role of microtubules in C. elegans polarity. The Journal of Cell Biology. 179: 367-9. PMID 17984317 DOI: 10.1083/Jcb.200710062  0.412
2007 Stitzel ML, Cheng KC, Seydoux G. Regulation of MBK-2/Dyrk kinase by dynamic cortical anchoring during the oocyte-to-zygote transition. Current Biology : Cb. 17: 1545-54. PMID 17869113 DOI: 10.1016/J.Cub.2007.08.049  0.766
2007 Stitzel ML, Seydoux G. Regulation of the oocyte-to-zygote transition. Science (New York, N.Y.). 316: 407-8. PMID 17446393 DOI: 10.1126/Science.1138236  0.755
2006 Seydoux G, Braun RE. Pathway to totipotency: lessons from germ cells. Cell. 127: 891-904. PMID 17129777 DOI: 10.1016/J.Cell.2006.11.016  0.409
2006 Gallo CM, Seydoux G. Toti "potent" repressors. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 28: 865-7. PMID 16937341 DOI: 10.1002/Bies.20454  0.421
2006 D'Agostino I, Merritt C, Chen PL, Seydoux G, Subramaniam K. Translational repression restricts expression of the C. elegans Nanos homolog NOS-2 to the embryonic germline. Developmental Biology. 292: 244-52. PMID 16499902 DOI: 10.1016/J.Ydbio.2005.11.046  0.689
2006 Hao Y, Boyd L, Seydoux G. Stabilization of cell polarity by the C. elegans RING protein PAR-2. Developmental Cell. 10: 199-208. PMID 16459299 DOI: 10.1016/J.Devcel.2005.12.015  0.638
2006 Stitzel ML, Pellettieri J, Seydoux G. The C. elegans DYRK Kinase MBK-2 Marks Oocyte Proteins for Degradation in Response to Meiotic Maturation. Current Biology : Cb. 16: 56-62. PMID 16338136 DOI: 10.1016/J.Cub.2005.11.063  0.815
2004 Seydoux G. Surfing the actomyosin wave: polarization of the C. elegans zygote. Developmental Cell. 7: 285-6. PMID 15363402 DOI: 10.1016/J.Devcel.2004.08.016  0.414
2004 DeRenzo C, Seydoux G. A clean start: degradation of maternal proteins at the oocyte-to-embryo transition. Trends in Cell Biology. 14: 420-6. PMID 15308208 DOI: 10.1016/J.Tcb.2004.07.005  0.781
2003 Pellettieri J, Reinke V, Kim SK, Seydoux G. Coordinate activation of maternal protein degradation during the egg-to-embryo transition in C. elegans. Developmental Cell. 5: 451-62. PMID 12967564 DOI: 10.1016/S1534-5807(03)00231-4  0.812
2003 DeRenzo C, Reese KJ, Seydoux G. Exclusion of germ plasm proteins from somatic lineages by cullin-dependent degradation. Nature. 424: 685-9. PMID 12894212 DOI: 10.1038/Nature01887  0.747
2003 Cuenca AA, Schetter A, Aceto D, Kemphues K, Seydoux G. Polarization of the C. elegans zygote proceeds via distinct establishment and maintenance phases. Development (Cambridge, England). 130: 1255-65. PMID 12588843 DOI: 10.1242/Dev.00284  0.485
2003 Subramaniam K, Seydoux G. Dedifferentiation of primary spermatocytes into germ cell tumors in C. elegans lacking the pumilio-like protein PUF-8. Current Biology : Cb. 13: 134-9. PMID 12546787 DOI: 10.1016/S0960-9822(03)00005-8  0.501
2002 Pellettieri J, Seydoux G. Anterior-posterior polarity in C. elegans and Drosophila--PARallels and differences. Science (New York, N.Y.). 298: 1946-50. PMID 12471246 DOI: 10.1126/Science.1072162  0.786
2002 Wallenfang MR, Seydoux G. cdk-7 Is required for mRNA transcription and cell cycle progression in Caenorhabditis elegans embryos. Proceedings of the National Academy of Sciences of the United States of America. 99: 5527-32. PMID 11960010 DOI: 10.1073/Pnas.082618399  0.793
2001 Strome S, Powers J, Dunn M, Reese K, Malone CJ, White J, Seydoux G, Saxton W. Spindle dynamics and the role of gamma-tubulin in early Caenorhabditis elegans embryos. Molecular Biology of the Cell. 12: 1751-64. PMID 11408582 DOI: 10.1091/Mbc.12.6.1751  0.796
2001 Tenenhaus C, Subramaniam K, Dunn MA, Seydoux G. PIE-1 is a bifunctional protein that regulates maternal and zygotic gene expression in the embryonic germ line of Caenorhabditis elegans. Genes & Development. 15: 1031-40. PMID 11316796 DOI: 10.1101/Gad.876201  0.488
2001 Seydoux G, Schedl T. The germline in C. elegans: origins, proliferation, and silencing. International Review of Cytology. 203: 139-85. PMID 11131515 DOI: 10.1016/S0074-7696(01)03006-6  0.444
2000 Halpern M, Seydoux G. Embryo emergent: elucidating the cell biology of development. The Santa Cruz Conference on Developmental Biology 2000. Embo Reports. 1: 469-72. PMID 11263487 DOI: 10.1093/Embo-Reports/Kvd115  0.347
2000 Golden A, Sadler PL, Wallenfang MR, Schumacher JM, Hamill DR, Bates G, Bowerman B, Seydoux G, Shakes DC. Metaphase to anaphase (mat) transition-defective mutants in Caenorhabditis elegans. The Journal of Cell Biology. 151: 1469-82. PMID 11134076 DOI: 10.1083/Jcb.151.7.1469  0.793
2000 Wallenfang MR, Seydoux G. Polarization of the anterior-posterior axis of C. elegans is a microtubule-directed process. Nature. 408: 89-92. PMID 11081513 DOI: 10.1038/35040562  0.796
2000 Reese KJ, Dunn MA, Waddle JA, Seydoux G. Asymmetric segregation of PIE-1 in C. elegans is mediated by two complementary mechanisms that act through separate PIE-1 protein domains. Molecular Cell. 6: 445-55. PMID 10983990 DOI: 10.1016/S1097-2765(00)00043-5  0.821
1999 Subramaniam K, Seydoux G. nos-1 and nos-2, two genes related to Drosophila nanos, regulate primordial germ cell development and survival in Caenorhabditis elegans. Development (Cambridge, England). 126: 4861-71. PMID 10518502  0.329
1999 Batchelder C, Dunn MA, Choy B, Suh Y, Cassie C, Shim EY, Shin TH, Mello C, Seydoux G, Blackwell TK. Transcriptional repression by the Caenorhabditis elegans germ-line protein PIE-1. Genes & Development. 13: 202-12. PMID 9925644 DOI: 10.1101/Gad.13.2.202  0.418
1998 Tenenhaus C, Schubert C, Seydoux G. Genetic requirements for PIE-1 localization and inhibition of gene expression in the embryonic germ lineage of Caenorhabditis elegans. Developmental Biology. 200: 212-24. PMID 9705228 DOI: 10.1006/Dbio.1998.8940  0.401
1997 Seydoux G, Dunn MA. Transcriptionally repressed germ cells lack a subpopulation of phosphorylated RNA polymerase II in early embryos of Caenorhabditis elegans and Drosophila melanogaster. Development (Cambridge, England). 124: 2191-201. PMID 9187145  0.311
1996 Seydoux G. Mechanisms of translational control in early development. Current Opinion in Genetics & Development. 6: 555-61. PMID 8939728 DOI: 10.1016/S0959-437X(96)80083-9  0.374
1996 Seydoux G, Mello CC, Pettitt J, Wood WB, Priess JR, Fire A. Repression of gene expression in the embryonic germ lineage of C. elegans. Nature. 382: 713-6. PMID 8751441 DOI: 10.1038/382713A0  0.649
1995 Seydoux G, Fire A. Whole-mount in situ hybridization for the detection of RNA in Caenorhabditis elegans embryos. Methods in Cell Biology. 48: 323-37. PMID 8531733 DOI: 10.1016/S0091-679X(08)61394-1  0.603
1994 Bucher EA, Seydoux G. Gastrulation in the nematode Caenorhabditis elegans Seminars in Developmental Biology. 5: 121-130. DOI: 10.1006/Sedb.1994.1016  0.373
1993 Seydoux G, Savage C, Greenwald I. Isolation and characterization of mutations causing abnormal eversion of the vulva in Caenorhabditis elegans. Developmental Biology. 157: 423-36. PMID 8500652 DOI: 10.1006/Dbio.1993.1146  0.331
1991 DeVoti J, Seydoux G, Beach D, McLeod M. Interaction between ran1+ protein kinase and cAMP dependent protein kinase as negative regulators of fission yeast meiosis. The Embo Journal. 10: 3759-68. PMID 1657594 DOI: 10.1002/J.1460-2075.1991.Tb04945.X  0.467
1990 Seydoux G, Schedl T, Greenwald I. Cell-cell interactions prevent a potential inductive interaction between soma and germline in C. elegans. Cell. 61: 939-51. PMID 2350786 DOI: 10.1016/0092-8674(90)90060-R  0.353
1990 Greenwald I, Seydoux G. Analysis of gain-of-function mutations of the lin-12 gene of Caenorhabditis elegans. Nature. 346: 197-9. PMID 2164160 DOI: 10.1038/346197A0  0.318
1989 Seydoux G, Greenwald I. Cell autonomy of lin-12 function in a cell fate decision in C. elegans. Cell. 57: 1237-45. PMID 2736627 DOI: 10.1016/0092-8674(89)90060-3  0.33
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