| Year |
Citation |
Score |
| 2022 |
Steimbach RR, Herbst-Gervasoni CJ, Lechner S, Stewart TM, Klinke G, Ridinger J, Géraldy MNE, Tihanyi G, Foley JR, Uhrig U, Kuster B, Poschet G, Casero RA, Médard G, Oehme I, et al. Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout. Journal of the American Chemical Society. PMID 36200994 DOI: 10.1021/jacs.2c05030 |
0.316 |
|
| 2022 |
Stewart TM, Foley JR, Holbert CE, Klinke G, Poschet G, Steimbach RR, Miller AK, Casero RA. Histone deacetylase 10 liberates spermidine to support polyamine homeostasis and tumor cell growth. The Journal of Biological Chemistry. 102407. PMID 35988653 DOI: 10.1016/j.jbc.2022.102407 |
0.317 |
|
| 2021 |
Al-Hamashi AA, Koranne R, Dlamini S, Alqahtani A, Karaj E, Rashid MS, Knoff JR, Dunworth M, Pflum MKH, Casero RA, Perera L, Taylor WR, Tillekeratne LMV. A new class of cytotoxic agents targets tubulin and disrupts microtubule dynamics. Bioorganic Chemistry. 116: 105297. PMID 34509798 DOI: 10.1016/j.bioorg.2021.105297 |
0.308 |
|
| 2020 |
Holbert CE, Dunworth M, Foley JR, Dunston TT, Stewart TM, Casero RA. Autophagy induction by exogenous polyamines is an artifact of bovine serum amine oxidase activity in culture serum. The Journal of Biological Chemistry. 295: 9061-9068. PMID 33516501 DOI: 10.1074/jbc.RA120.013867 |
0.325 |
|
| 2020 |
Holbert CE, Dunworth M, Foley JR, Dunston TT, Murray Stewart T, Casero RA. Autophagy induction by exogenous polyamines is an artifact of bovine serum amine oxidase activity in culture serum. The Journal of Biological Chemistry. PMID 32430398 DOI: 10.1074/jbc.RA120.013867 |
0.722 |
|
| 2020 |
Murray Stewart T, Khomutov M, Foley JR, Guo X, Holbert CE, Dunston TT, Schwartz CE, Gabrielson K, Khomutov A, Casero RA. (R,R)-1,12-Dimethylspermine can mitigate abnormal spermidine accumulation in Snyder-Robinson syndrome. The Journal of Biological Chemistry. PMID 31996374 DOI: 10.1074/Jbc.Ra119.011572 |
0.715 |
|
| 2018 |
Murray-Stewart T, Dunworth M, Foley JR, Schwartz CE, Casero RA. Polyamine Homeostasis in Snyder-Robinson Syndrome. Medical Sciences (Basel, Switzerland). 6. PMID 30544565 DOI: 10.3390/medsci6040112 |
0.318 |
|
| 2018 |
Murray Stewart T, Dunston TT, Woster PM, Casero RA. Polyamine catabolism and oxidative damage. The Journal of Biological Chemistry. PMID 30333229 DOI: 10.1074/Jbc.Tm118.003337 |
0.699 |
|
| 2018 |
Murray-Stewart T, Dunworth M, Lui Y, Giardiello FM, Woster PM, Casero RA. Curcumin mediates polyamine metabolism and sensitizes gastrointestinal cancer cells to antitumor polyamine-targeted therapies. Plos One. 13: e0202677. PMID 30138353 DOI: 10.1371/Journal.Pone.0202677 |
0.334 |
|
| 2016 |
Almaliti J, Al-Hamashi AA, Negmeldin AT, Hanigan CL, Perera L, Pflum MK, Casero RA, Tillekeratne LM. Largazole Analogues Embodying Radical Changes in the Depsipeptide Ring: Development of a More Selective and Highly Potent Analogue. Journal of Medicinal Chemistry. PMID 27809521 DOI: 10.1021/Acs.Jmedchem.6B01271 |
0.723 |
|
| 2015 |
Nowotarski SL, Pachaiyappan B, Holshouser SL, Kutz CJ, Li Y, Huang Y, Sharma SK, Casero RA, Woster PM. Structure-activity study for (bis)ureidopropyl- and (bis)thioureidopropyldiamine LSD1 inhibitors with 3-5-3 and 3-6-3 carbon backbone architectures. Bioorganic & Medicinal Chemistry. 23: 1601-12. PMID 25725609 DOI: 10.1016/J.Bmc.2015.01.049 |
0.31 |
|
| 2014 |
Bhansali P, Hanigan CL, Perera L, Casero RA, Tillekeratne LM. Synthesis and biological evaluation of largazole analogues with modified surface recognition cap groups. European Journal of Medicinal Chemistry. 86: 528-41. PMID 25203782 DOI: 10.1016/J.Ejmech.2014.09.009 |
0.734 |
|
| 2014 |
Prusevich P, Kalin JH, Ming SA, Basso M, Givens J, Li X, Hu J, Taylor MS, Cieniewicz AM, Hsiao PY, Huang R, Roberson H, Adejola N, Avery LB, Casero RA, et al. A selective phenelzine analogue inhibitor of histone demethylase LSD1. Acs Chemical Biology. 9: 1284-93. PMID 24707965 DOI: 10.1021/Cb500018S |
0.38 |
|
| 2014 |
Murray-Stewart T, Woster PM, Casero RA. The re-expression of the epigenetically silenced e-cadherin gene by a polyamine analogue lysine-specific demethylase-1 (LSD1) inhibitor in human acute myeloid leukemia cell lines Amino Acids. 46: 585-594. PMID 23508577 DOI: 10.1007/S00726-013-1485-1 |
0.317 |
|
| 2013 |
Murray-Stewart T, Hanigan CL, Woster PM, Marton LJ, Casero RA. Histone deacetylase inhibition overcomes drug resistance through a miRNA-dependent mechanism Molecular Cancer Therapeutics. 12: 2088-2099. PMID 23943804 DOI: 10.1158/1535-7163.Mct-13-0418 |
0.728 |
|
| 2013 |
Jin L, Hanigan CL, Wu Y, Wang W, Park BH, Woster PM, Casero RA. Loss of LSD1 (lysine-specific demethylase 1) suppresses growth and alters gene expression of human colon cancer cells in a p53- and DNMT1 (DNA methyltransferase 1)-independent manner Biochemical Journal. 449: 459-468. PMID 23072722 DOI: 10.1042/Bj20121360 |
0.724 |
|
| 2012 |
Hazeldine S, Pachaiyappan B, Steinbergs N, Nowotarski S, Hanson AS, Casero RA, Woster PM. Low molecular weight amidoximes that act as potent inhibitors of lysine-specific demethylase 1 Journal of Medicinal Chemistry. 55: 7378-7391. PMID 22876979 DOI: 10.1021/Jm3002845 |
0.344 |
|
| 2012 |
Wu Y, Steinbergs N, Murray-Stewart T, Marton LJ, Casero RA. Oligoamine analogues in combination with 2-difluoromethylornithine synergistically induce re-expression of aberrantly silenced tumour-suppressor genes. The Biochemical Journal. 442: 693-701. PMID 22132744 DOI: 10.1042/BJ20111271 |
0.331 |
|
| 2012 |
Fraser AV, Goodwin AC, Hacker-Prietz A, Sugar E, Woster PM, Casero RA. Knockdown of ornithine decarboxylase antizyme 1 causes loss of uptake regulation leading to increased N1, N11-bis(ethyl)norspermine (BENSpm) accumulation and toxicity in NCI H157 lung cancer cells. Amino Acids. 42: 529-38. PMID 21814790 DOI: 10.1007/S00726-011-1030-Z |
0.318 |
|
| 2011 |
Bhansali P, Hanigan CL, Casero RA, Tillekeratne LM. Largazole and analogues with modified metal-binding motifs targeting histone deacetylases: synthesis and biological evaluation. Journal of Medicinal Chemistry. 54: 7453-63. PMID 21936551 DOI: 10.1021/Jm200432A |
0.734 |
|
| 2011 |
Schenk T, Göllner S, Chen WC, Howell L, Jin L, Hebestreit K, Klein H, Burnett AK, Mills KI, Marton L, Casero R, Woster P, Dugas M, Wang JC, Dick JE, et al. Histone H3 Methylation Mediates All-Trans-Retinoic Acid Responsiveness in Acute Myeloid Leukemia Blood. 118: 224-224. DOI: 10.1182/Blood.V118.21.224.224 |
0.425 |
|
| 2010 |
Sharma SK, Wu Y, Steinbergs N, Crowley ML, Hanson AS, Casero RA, Woster PM. (Bis)urea and (Bis)thiourea inhibitors of lysine-specific demethylase 1 as epigenetic modulators Journal of Medicinal Chemistry. 53: 5197-5212. PMID 20568780 DOI: 10.1021/Jm100217A |
0.338 |
|
| 2010 |
Goodwin A, Wu S, Huso D, Wu X, Hicks J, Shields CD, Hacker-Prietz A, Rabizadeh S, Marzo AD, Sears C, Casero R. Abstract A56: Induction of spermine oxidase by enterotoxigenic Bacteroides fragilis contributes to tumorigenesis in a model of colitis-associated colorectal cancer Cancer Prevention Research. 3. DOI: 10.1158/1940-6207.Prev-10-A56 |
0.348 |
|
| 2009 |
Huang Y, Marton LJ, Woster PM, Casero RA. Polyamine analogues targeting epigenetic gene regulation Essays in Biochemistry. 46: 95-110. PMID 20095972 DOI: 10.1042/Bse0460007 |
0.344 |
|
| 2009 |
Petrie KR, Schenk T, Chornet MB, Howell L, Dick JE, Marquez VE, Marton LJ, Woster PM, Casero RA, Zelent A. Modulation of Histone H3K4 and H3K27 Methylation Levels Via Pharmacological Inhibition of LSD1 and Degradation of the EZH2-Containing Polycomb Repressive Complex 2 Stimulates ATRA-Mediated Differentiation of AML Cells. Blood. 114: 1046-1046. DOI: 10.1182/blood.V114.22.1046.1046 |
0.34 |
|
| 2008 |
Varghese S, Senanayake T, Murray-Stewart T, Doering K, Fraser A, Casero RA, Woster PM. Polyaminohydroxamic acids and polyaminobenzamides as isoform selective histone deacetylase inhibitors Journal of Medicinal Chemistry. 51: 2447-2456. PMID 18348516 DOI: 10.1021/Jm701384X |
0.307 |
|
| 2007 |
Jiang R, Choi W, Khan A, Hess K, Gerner EW, Casero RA, Yung WK, Hamilton SR, Zhang W. Activation of polyamine catabolism by N1,N11-diethylnorspermine leads to cell death in glioblastoma. International Journal of Oncology. 31: 431-40. PMID 17611701 |
0.324 |
|
| 2007 |
Boncher T, Bi X, Varghese S, Casero RA, Woster PM. Polyamine-based analogues as biochemical probes and potential therapeutics Biochemical Society Transactions. 35: 356-363. PMID 17371278 DOI: 10.1042/Bst0350356 |
0.332 |
|
| 2007 |
Babbar N, Murray-Stewart T, Casero RA. Inflammation and polyamine catabolism: the good, the bad and the ugly. Biochemical Society Transactions. 35: 300-4. PMID 17371265 DOI: 10.1042/BST0350300 |
0.307 |
|
| 2005 |
Casero RA, Frydman B, Stewart TM, Woster PM. Significance of targeting polyamine metabolism as an antineoplastic strategy: unique targets for polyamine analogues. Proceedings of the Western Pharmacology Society. 48: 24-30. PMID 16416654 |
0.307 |
|
| 2005 |
Pledgie A, Huang Y, Hacker A, Zhang Z, Woster PM, Davidson NE, Casero RA. Spermine oxidase SMO(PAOh1), not N1-acetylpolyamine oxidase PAO, is the primary source of Cytotoxic H2O2 in polyamine analogue-treated human breast cancer cell lines Journal of Biological Chemistry. 280: 39843-39851. PMID 16207710 DOI: 10.1074/Jbc.M508177200 |
0.317 |
|
| 2005 |
Varghese S, Gupta D, Baran T, Jiemjit A, Gore SD, Casero RA, Woster PM. Alkyl-substituted polyaminohydroxamic acids: A novel class of targeted histone deacetylase inhibitors Journal of Medicinal Chemistry. 48: 6350-6365. PMID 16190761 DOI: 10.1021/Jm0505009 |
0.323 |
|
| 2005 |
Huang Y, Pledgie A, Rubin E, Marton LJ, Woster PM, Sukumar S, Casero RA, Davidson NE. Role of p53/p21Waf1/Cip1 in the regulation of polyamine analogue-induced growth inhibition and cell death in human breast cancer cells Cancer Biology and Therapy. 4: 1006-1013. PMID 16131835 DOI: 10.4161/Cbt.4.9.1970 |
0.304 |
|
| 2005 |
Huang Y, Pledgie A, Casero RA, Davidson NE. Molecular mechanisms of polyamine analogs in cancer cells. Anti-Cancer Drugs. 16: 229-41. PMID 15711175 DOI: 10.1097/00001813-200503000-00002 |
0.34 |
|
| 2004 |
Huang Y, Keen JC, Hager E, Smith R, Hacker A, Frydman B, Valasinas AL, Reddy VK, Marton LJ, Casero RA, Davidson NE. Regulation of polyamine analogue cytotoxicity by c-Jun in human MDA-MB-435 cancer cells. Molecular Cancer Research : McR. 2: 81-8. PMID 14985464 |
0.306 |
|
| 2003 |
Babbar N, Ignatenko NA, Casero RA, Gerner EW. Cyclooxygenase-independent induction of apoptosis by sulindac sulfone is mediated by polyamines in colon cancer. The Journal of Biological Chemistry. 278: 47762-75. PMID 14506281 DOI: 10.1074/Jbc.M307265200 |
0.321 |
|
| 2003 |
Kwak MK, Kensler TW, Casero RA. Induction of phase 2 enzymes by serum oxidized polyamines through activation of Nrf2: effect of the polyamine metabolite acrolein. Biochemical and Biophysical Research Communications. 305: 662-70. PMID 12763045 DOI: 10.1016/S0006-291X(03)00834-9 |
0.321 |
|
| 2003 |
Zahedi K, Wang Z, Barone S, Prada AE, Kelly CN, Casero RA, Yokota N, Porter CW, Rabb H, Soleimani M. Expression of SSAT, a novel biomarker of tubular cell damage, increases in kidney ischemia-reperfusion injury American Journal of Physiology - Renal Physiology. 284: F1046-F1055. PMID 12554636 DOI: 10.1152/Ajprenal.00318.2002 |
0.624 |
|
| 1998 |
Berchtold CM, Tamez P, Kensler TW, Casero RA. Inhibition of cell growth in CaCO2 cells by the polyamine analogue N1,N12-bis(ethyl)spermine is preceded by a reduction in MYC oncoprotein levels. Journal of Cellular Physiology. 174: 380-6. PMID 9462700 DOI: 10.1002/(Sici)1097-4652(199803)174:3<380::Aid-Jcp12>3.0.Co;2-D |
0.326 |
|
| 1997 |
Ha HC, Woster PM, Yager JD, Casero RA. The role of polyamine catabolism in polyamine analogue-induced programmed cell death Proceedings of the National Academy of Sciences of the United States of America. 94: 11557-11562. PMID 9326648 DOI: 10.1073/Pnas.94.21.11557 |
0.316 |
|
| 1995 |
Yang J, Xiao L, Berkey KA, Tamez PA, Coward JK, Casero RA. Significant induction of spermidine/spermine N1-acetyltransferase without cytotoxicity by the growth-supporting polyamine analogue 1,12-dimethylspermine. Journal of Cellular Physiology. 165: 71-6. PMID 7559809 DOI: 10.1002/Jcp.1041650109 |
0.323 |
|
| 1993 |
Saab NH, West EE, Bieszk NC, Preuss CV, Mank AR, Casero RA, Woster PM. Synthesis and evaluation of unsymmetrically substituted polyamine analogues as modulators of human spermidine/spermine-N1-acetyltransferase (SSAT) and as potential antitumor agents. Journal of Medicinal Chemistry. 36: 2998-3004. PMID 8411017 DOI: 10.1021/Jm00072A020 |
0.326 |
|
| 1984 |
Casero RA, Bergeron RJ, Porter CW. Treatment with α-difluoromethylornithine plus a spermidine analog leads to spermine depletion and growth inhibition in cultured L1210 leukemia cells Journal of Cellular Physiology. 121: 476-482. PMID 6438117 DOI: 10.1002/Jcp.1041210305 |
0.303 |
|
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