Francis Ali-Osman - Publications

Affiliations: 
The University of Texas Graduate School of Biomedical Sciences at Houston 
Area:
Molecular Biology, Cell Biology, Oncology

92 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Madala HR, Punganuru SR, Ali-Osman F, Zhang R, Srivenugopal KS. Brain- and brain tumor-penetrating disulfiram nanoparticles: Sequence of cytotoxic events and efficacy in human glioma cell lines and intracranial xenografts. Oncotarget. 9: 3459-3482. PMID 29423059 DOI: 10.18632/Oncotarget.23320  0.364
2017 Gabr M, Marcus S, Madala HR, Srivenugopal KS, Ali-Osman F. Abstract 4053: Disulfiram-copper combination induces cell death time- and schedule-dependently in glioblastoma (GBM) and medulloblastoma cell lines, and enhances temozolomide sensitivity of methylator+ve GBM cellsin vitroandin vivo Cancer Research. 77: 4053-4053. DOI: 10.1158/1538-7445.Am2017-4053  0.378
2017 Madala HR, Punganuru SR, Ali-Osman F, Srivenugopal KS. Abstract 2044: Development of stable and brain-penetrating disulfiram nanoparticles, characterization and efficacy in glioma cell culture and xenograft models Cancer Research. 77: 2044-2044. DOI: 10.1158/1538-7445.Am2017-2044  0.38
2016 Paranjpe A, Bailey NI, Konduri S, Bobustuc GC, Ali-Osman F, Yusuf MA, Punganuru SR, Madala HR, Basak D, Mostofa A, Srivenugopal KS. New insights into estrogenic regulation of O(6)-methylguanine DNA-methyltransferase (MGMT) in human breast cancer cells: Co-degradation of ER-α and MGMT proteins by fulvestrant or O(6)-benzylguanine indicates fresh avenues for therapy. Journal of Biomedical Research. 30: 393-410. PMID 27845303 DOI: 10.7555/Jbr.30.20160040  0.335
2016 Lai RK, Zhou R, Amirian ES, Johansen C, Scheurer ME, Armstrong GN, Lau CC, Claus EB, Barnholtz-Sloan JS, Il’yasova D, Schildkraut J, Ali-Osman F, Sadetzki S, Houlston R, Jenkins RB, et al. Abstract 3446: Aspirin, non-steroidal anti-inflammatory drugs (NSAIDs) and the risk of glioma: Results from the Glioma International Case Control Study Cancer Research. 76: 3446-3446. DOI: 10.1158/1538-7445.Am2016-3446  0.317
2015 Okamura T, Antoun G, Keir ST, Friedman H, Bigner DD, Ali-Osman F. Phosphorylation of GSTP1 by EGFR Promotes Formation of the Inhibitory GSTP1-JNK Complex and Suppresses JNK Downstream Signaling and Apoptosis in Brain Tumor Cells. The Journal of Biological Chemistry. PMID 26429914 DOI: 10.1074/Jbc.M115.656140  0.412
2015 Brown KE, Chagoya G, Kwatra SG, Yen T, Keir ST, Cooter M, Hoadley KA, Rasheed A, Lipp ES, Mclendon R, Ali-Osman F, Bigner DD, Sampson JH, Kwatra MM. Proteomic profiling of patient-derived glioblastoma xenografts identifies a subset with activated EGFR: implications for drug development. Journal of Neurochemistry. 133: 730-8. PMID 25598002 DOI: 10.1111/Jnc.13032  0.391
2014 Lidsky M, Antoun G, Speicher P, Adams B, Turley R, Augustine C, Tyler D, Ali-Osman F. Mitogen-activated protein kinase (MAPK) hyperactivation and enhanced NRAS expression drive acquired vemurafenib resistance in V600E BRAF melanoma cells. The Journal of Biological Chemistry. 289: 27714-26. PMID 25063807 DOI: 10.1074/Jbc.M113.532432  0.397
2014 Paranjpe A, Zhang R, Ali-Osman F, Bobustuc GC, Srivenugopal KS. Disulfiram is a direct and potent inhibitor of human O6-methylguanine-DNA methyltransferase (MGMT) in brain tumor cells and mouse brain and markedly increases the alkylating DNA damage. Carcinogenesis. 35: 692-702. PMID 24193513 DOI: 10.1093/Carcin/Bgt366  0.394
2013 Yang W, Wang L, Roehn G, Pearlstein RD, Ali-Osman F, Pan H, Goldbrunner R, Krantz M, Harms C, Paschen W. Small ubiquitin-like modifier 1-3 conjugation [corrected] is activated in human astrocytic brain tumors and is required for glioblastoma cell survival. Cancer Science. 104: 70-7. PMID 23078246 DOI: 10.1111/Cas.12047  0.398
2013 Antoun GR, Ali-Osman F. Abstract 783: Mutational status of the p53 tumor suppressor gene is associated with expression of GSTP1 allelic variants in human GBM.. Cancer Research. 73: 783-783. DOI: 10.1158/1538-7445.Am2013-783  0.441
2012 Okamura T, Ali-Osman F. Abstract 2162: EGFR-induced interaction of GSTP1 with the SH2-domain of Grb2 enhances Ras downstream activation in human glioma cells Cancer Research. 72: 2162-2162. DOI: 10.1158/1538-7445.Am2012-2162  0.388
2012 Turley RS, Lidsky ME, Tyler DS, Ali-Osman F. Abstract 2012: MAP kinase activation and suppression of anti-apoptotic Bcl-2 family members are associated with induction of apoptotic death in melanoma cells following down-regulation of glutathione S-transferase P1 Cancer Research. 72: 2012-2012. DOI: 10.1158/1538-7445.Am2012-2012  0.412
2012 Antoun GR, McLendon R, Friedman H, Friedman A, Bigner D, Ali-Osman F. Abstract 1177: The mutational status of the p53 tumor suppressor gene is a determinant of GSTP1 expression and mediates GSTP1-dependent drug resistance in human glioblastoma Cancer Research. 72: 1177-1177. DOI: 10.1158/1538-7445.Am2012-1177  0.433
2012 Turley R, Augustine C, Lidsky M, Tyler D, Ali-Osman F. GSTP1 Suppression Induces Apoptosis in Melanoma Cells Independent of BRAF Mutational Status Journal of Surgical Research. 172: 229. DOI: 10.1016/J.Jss.2011.11.346  0.303
2011 Cao X, Zhu H, Ali-Osman F, Lo HW. EGFR and EGFRvIII undergo stress- and EGFR kinase inhibitor-induced mitochondrial translocalization: a potential mechanism of EGFR-driven antagonism of apoptosis. Molecular Cancer. 10: 26. PMID 21388543 DOI: 10.1186/1476-4598-10-26  0.591
2011 Okamura T, Ali-osman F. Abstract 703: GSTP1 inhibition of HSP27 phosphorylation contributes to glioma drug resistance Cancer Research. 71: 703-703. DOI: 10.1158/1538-7445.Am2011-703  0.378
2011 Cao X, Dewhirst M, Ali-Osman F, Lo H. Abstract 2337: Defining significance of the novel tGLI1 transcription factor in cancer growth and progression Cancer Research. 71: 2337-2337. DOI: 10.1158/1538-7445.Am2011-2337  0.617
2011 Turley RS, Liu J, Tyler D, Ali-Osman F. Abstract 1635: Short hairpin RNA-mediated transcriptional suppression of glutathione S-transferase P1 suppresses growth and induces apoptosis through altered MAP kinase signaling in melanoma cells Cancer Research. 71: 1635-1635. DOI: 10.1158/1538-7445.Am2011-1635  0.314
2011 Ali-Osman F, Okamura T, Turley R, Barker A, Keck JG, Laborde E, Cai D, Mascata R. Abstract B229: Novel ezatiostat analogues disrupt binding of GSTP1 to all three major MAP kinases (JNK, ERK and p38) and exhibit context-dependent antitumor activity. Molecular Cancer Therapeutics. 10. DOI: 10.1158/1535-7163.Targ-11-B229  0.423
2011 Ali-Osman F, Owzar K, Lipp E, Adams B, Illyasova D, McClendon R, Reardon D, Friedman A, Friedman H, Bigner D. Abstract PL07-01: Linkage disequilibrium-based analysis of DNA repair and GST genes in malignant gliomas: A unique tool in defining the association between genetic diversity and survival Cancer Epidemiology, Biomarkers & Prevention. 20. DOI: 10.1158/1055-9965.Disp-11-Pl07-01  0.38
2010 Cui B, Johnson SP, Bullock N, Ali-Osman F, Bigner DD, Friedman HS. Decoupling of DNA damage response signaling from DNA damages underlies temozolomide resistance in glioblastoma cells. Journal of Biomedical Research. 24: 424-35. PMID 23554659 DOI: 10.1016/S1674-8301(10)60057-7  0.344
2010 Advani AS, Shadman M, Ali-Osman F, Barker A, Rybicki L, Kalaycio M, Sekeres MA, de Castro CM, Diehl LF, Moore JO, Beaven A, Copelan E, Sobecks R, Talea P, Rizzieri DA. A Phase II trial of gemcitabine and mitoxantrone for patients with acute myeloid leukemia in first relapse. Clinical Lymphoma, Myeloma & Leukemia. 10: 473-6. PMID 21156465 DOI: 10.3816/Clml.2010.N.082  0.316
2010 Singh S, Okamura T, Ali-Osman F. Serine phosphorylation of glutathione S-transferase P1 (GSTP1) by PKCα enhances GSTP1-dependent cisplatin metabolism and resistance in human glioma cells. Biochemical Pharmacology. 80: 1343-55. PMID 20654585 DOI: 10.1016/J.Bcp.2010.07.019  0.4
2010 Augustine CK, Toshimitsu H, Jung SH, Zipfel PA, Yoo JS, Yoshimoto Y, Selim MA, Burchette J, Beasley GM, McMahon N, Padussis J, Pruitt SK, Ali-Osman F, Tyler DS. Sorafenib, a multikinase inhibitor, enhances the response of melanoma to regional chemotherapy Molecular Cancer Therapeutics. 9: 2090-2101. PMID 20571072 DOI: 10.1158/1535-7163.Mct-10-0073  0.417
2010 Crout CA, Koh LP, Gockerman JP, Moore JO, Decastro C, Long GD, Diehl L, Gasparetto C, Niedzwiecki D, Edwards J, Prosnitz L, Horwitz M, Chute J, Morris A, Davis P, ... ... Ali-Osman F, et al. Overcoming drug resistance in mantle cell lymphoma using a combination of dose-dense and intense therapy. Cancer Investigation. 28: 654-60. PMID 20521909 DOI: 10.3109/07357901003631015  0.356
2010 Augustine CK, Jung SH, Sohn I, Yoo JS, Yoshimoto Y, Olson JA, Friedman HS, Ali-Osman F, Tyler DS. Gene expression signatures as a guide to treatment strategies for in-transit metastatic melanoma. Molecular Cancer Therapeutics. 9: 779-90. PMID 20371714 DOI: 10.1158/1535-7163.Mct-09-0764  0.374
2010 Toshimitsu H, Yoshimoto Y, Augustine CK, Padussis JC, Yoo JS, Angelica Selim M, Pruitt SK, Friedman HS, Ali-Osman F, Tyler DS. Inhibition of poly(ADP-ribose) polymerase enhances the effect of chemotherapy in an animal model of regional therapy for the treatment of advanced extremity malignant melanoma. Annals of Surgical Oncology. 17: 2247-54. PMID 20182810 DOI: 10.1245/S10434-010-0971-X  0.322
2010 Zhu H, Cao X, Ali-Osman F, Keir S, Lo HW. EGFR and EGFRvIII interact with PUMA to inhibit mitochondrial translocalization of PUMA and PUMA-mediated apoptosis independent of EGFR kinase activity. Cancer Letters. 294: 101-10. PMID 20153921 DOI: 10.1016/J.Canlet.2010.01.028  0.616
2010 Lo HW, Cao X, Zhu H, Ali-Osman F. Cyclooxygenase-2 is a novel transcriptional target of the nuclear EGFR-STAT3 and EGFRvIII-STAT3 signaling axes. Molecular Cancer Research : McR. 8: 232-45. PMID 20145033 DOI: 10.1158/1541-7786.Mcr-09-0391  0.629
2010 Zhu H, Cao X, Keir S, Ali-Osman F, Lo H. Abstract LB-225: EGFR and EGFRvIII interact with PUMA to inhibit mitochondrial translocalization of PUMA and PUMA-mediated apoptosis independent of EGFR kinase activity Cancer Research. 70. DOI: 10.1158/1538-7445.Am10-Lb-225  0.635
2010 Zhu H, Cao X, Ali-Osman F, Lo H. Abstract 414: Identification and functional characterization of a novel tumor-specific gain-of-function GLI1 splice variant that promotes cancer migration and invasion Cancer Research. 70: 414-414. DOI: 10.1158/1538-7445.Am10-414  0.657
2010 Okamura T, Ali-Osman F. Abstract 4002: C-terminal phosphorylation of human GSTP1 by EGFR and site-directed mutation allows JNK reactivation in glioma cells Cancer Research. 70: 4002-4002. DOI: 10.1158/1538-7445.Am10-4002  0.375
2010 Lo H, Cao X, Zhu H, Ali-Osman F. Abstract 3117: COX-2 is a novel transcriptional target of the nuclear EGFR-STAT3 and EGFRvIII-STAT3 signaling axes Cancer Research. 70: 3117-3117. DOI: 10.1158/1538-7445.Am10-3117  0.636
2010 Singh S, Ali-Osman F. Abstract 2557: GSTP1 is a determinant of temozolomiode resistance in human glioblastoma cells Cancer Research. 70: 2557-2557. DOI: 10.1158/1538-7445.Am10-2557  0.41
2010 Antoun G, Ali-Osman F. Abstract 1109: Identification of a novel MDM2 splice transcript that lacks nuclear transport signals but harbors the p53 binding motif in human glioma cells Cancer Research. 70: 1109-1109. DOI: 10.1158/1538-7445.Am10-1109  0.388
2010 Ali-Osman F, Liu J. Abstract 1061: Glutathione S-transferase P1 is required for growth and survival of human glioma cells Cancer Research. 70: 1061-1061. DOI: 10.1158/1538-7445.Am10-1061  0.435
2009 Lo HW, Zhu H, Cao X, Aldrich A, Ali-Osman F. A novel splice variant of GLI1 that promotes glioblastoma cell migration and invasion. Cancer Research. 69: 6790-8. PMID 19706761 DOI: 10.1158/0008-5472.Can-09-0886  0.663
2009 Cui B, Johnson SP, Bullock N, Ali-Osman F, Bigner DD, Friedman HS. Bifunctional DNA alkylator 1,3-bis(2-chloroethyl)-1-nitrosourea activates the ATR-Chk1 pathway independently of the mismatch repair pathway. Molecular Pharmacology. 75: 1356-63. PMID 19261750 DOI: 10.1124/Mol.108.053124  0.324
2009 Okamura T, Singh S, Buolamwini J, Haystead T, Friedman H, Bigner D, Ali-Osman F. Tyrosine phosphorylation of the human glutathione S-transferase P1 by epidermal growth factor receptor. The Journal of Biological Chemistry. 284: 16979-89. PMID 19254954 DOI: 10.1074/Jbc.M808153200  0.428
2009 White R, Singh S, Hsu S, Viles K, Potti A, Nevins J, Ali-Osman F. 54: Development of a Gene Expression Profile for Predicting Gemcitabine Response in Pancreatic Cancer Journal of Surgical Research. 151: 195. DOI: 10.1016/J.Jss.2008.11.064  0.322
2008 Lo HW, Cao X, Zhu H, Ali-Osman F. Constitutively activated STAT3 frequently coexpresses with epidermal growth factor receptor in high-grade gliomas and targeting STAT3 sensitizes them to Iressa and alkylators. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 14: 6042-54. PMID 18829483 DOI: 10.1158/1078-0432.Ccr-07-4923  0.601
2008 Maxwell JA, Johnson SP, McLendon RE, Lister DW, Horne KS, Rasheed A, Quinn JA, Ali-Osman F, Friedman AH, Modrich PL, Bigner DD, Friedman HS. Mismatch repair deficiency does not mediate clinical resistance to temozolomide in malignant glioma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 14: 4859-68. PMID 18676759 DOI: 10.1158/1078-0432.Ccr-07-4807  0.351
2008 Lo HW, Stephenson L, Cao X, Milas M, Pollock R, Ali-Osman F. Identification and functional characterization of the human glutathione S-transferase P1 gene as a novel transcriptional target of the p53 tumor suppressor gene. Molecular Cancer Research : McR. 6: 843-50. PMID 18505928 DOI: 10.1158/1541-7786.Mcr-07-2105  0.636
2008 Xie TX, Aldape KD, Gong W, Kanzawa T, Suki D, Kondo S, Lang F, Ali-Osman F, Sawaya R, Huang S. Aberrant NF-κB activity is critical in focal necrosis formation of human glioblastoma by regulation of the expression of tissue factor International Journal of Oncology. 33: 5-15. DOI: 10.3892/Ijo.33.1.5  0.352
2007 Lo HW, Ali-Osman F. Genetic polymorphism and function of glutathione S-transferases in tumor drug resistance. Current Opinion in Pharmacology. 7: 367-74. PMID 17681492 DOI: 10.1016/J.Coph.2007.06.009  0.639
2007 Yoshimoto Y, Augustine CK, Yoo JS, Zipfel PA, Selim MA, Pruitt SK, Friedman HS, Ali-Osman F, Tyler DS. Defining regional infusion treatment strategies for extremity melanoma: comparative analysis of melphalan and temozolomide as regional chemotherapeutic agents. Molecular Cancer Therapeutics. 6: 1492-500. PMID 17483437 DOI: 10.1158/1535-7163.Mct-06-0718  0.393
2006 Maxwell JA, Johnson SP, Quinn JA, McLendon RE, Ali-Osman F, Friedman AH, Herndon JE, Bierau K, Bigley J, Bigner DD, Friedman HS. Quantitative analysis of O6-alkylguanine-DNA alkyltransferase in malignant glioma. Molecular Cancer Therapeutics. 5: 2531-9. PMID 17041097 DOI: 10.1158/1535-7163.Mct-06-0106  0.339
2005 Cheng CL, Johnson SP, Keir ST, Quinn JA, Ali-Osman F, Szabo C, Li H, Salzman AL, Dolan ME, Modrich P, Bigner DD, Friedman HS. Poly(ADP-ribose) polymerase-1 inhibition reverses temozolomide resistance in a DNA mismatch repair-deficient malignant glioma xenograft. Molecular Cancer Therapeutics. 4: 1364-8. PMID 16170028 DOI: 10.1158/1535-7163.Mct-05-0128  0.309
2005 Shou J, Srivenugopal KS, Mullapudi SRS, Lang FF, Rao JS, Ali-Osman F. Erratum: Enforced expression of wild-type p53 curtails the transcription of the O6-methylguanine-DNA methyltransferase gene in human tumor cells and enhances their sensitivity to alkylating agents (Clinical Cancer Research (May 1, 2001) 7 (1398-1409)) Clinical Cancer Research. 11. DOI: 10.1158/1078-0432.Ccr-11-6-Cor  0.406
2004 Lo HW, Antoun GR, Ali-Osman F. The human glutathione S-transferase P1 protein is phosphorylated and its metabolic function enhanced by the Ser/Thr protein kinases, cAMP-dependent protein kinase and protein kinase C, in glioblastoma cells. Cancer Research. 64: 9131-8. PMID 15604283 DOI: 10.1158/0008-5472.Can-04-0283  0.601
2004 Xie TX, Wei D, Liu M, Gao AC, Ali-Osman F, Sawaya R, Huang S. Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis. Oncogene. 23: 3550-60. PMID 15116091 DOI: 10.1038/Sj.Onc.1207383  0.336
2004 Barnette P, Scholl R, Blandford M, Ballard L, Tsodikov A, Magee J, Williams S, Robertson M, Ali-Osman F, Lemons R, Keller C. High-throughput detection of glutathione s-transferase polymorphic alleles in a pediatric cancer population. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 13: 304-13. PMID 14973099 DOI: 10.1158/1055-9965.Epi-03-0178  0.358
2003 Konduri SD, Srivenugopal KS, Yanamandra N, Dinh DH, Olivero WC, Gujrati M, Foster DC, Kisiel W, Ali-Osman F, Kondraganti S, Lakka SS, Rao JS. Promoter methylation and silencing of the tissue factor pathway inhibitor-2 (TFPI-2), a gene encoding an inhibitor of matrix metalloproteinases in human glioma cells. Oncogene. 22: 4509-16. PMID 12881707 DOI: 10.1038/Sj.Onc.1206695  0.392
2003 Wang Y, Spitz MR, Schabath MB, Ali-Osman F, Mata H, Wu X. Association between glutathione S-transferase p1 polymorphisms and lung cancer risk in Caucasians: a case-control study. Lung Cancer (Amsterdam, Netherlands). 40: 25-32. PMID 12660004 DOI: 10.1016/S0169-5002(02)00537-8  0.328
2002 Srivenugopal KS, Mullapudi SR, Ali-Osman F. Phosphorylation of O6-alkylguanine-DNA alkyltransferase: experience with a GST-fusion protein and a new pull-down assay. Cancer Letters. 181: 87-93. PMID 12430183 DOI: 10.1016/S0304-3835(01)00823-0  0.331
2002 Ishimoto TM, Ali-Osman F. Allelic variants of the human glutathione S-transferase P1 gene confer differential cytoprotection against anticancer agents in Escherichia coli. Pharmacogenetics. 12: 543-53. PMID 12360105 DOI: 10.1097/00008571-200210000-00006  0.643
2002 Lo HW, Ali-Osman F. Cyclic AMP mediated GSTP1 gene activation in tumor cells involves the interaction of activated CREB-1 with the GSTP1 CRE: a novel mechanism of cellular GSTP1 gene regulation. Journal of Cellular Biochemistry. 87: 103-16. PMID 12210727 DOI: 10.1002/Jcb.10275  0.67
2002 Srivenugopal KS, Ali-Osman F. The DNA repair protein, O(6)-methylguanine-DNA methyltransferase is a proteolytic target for the E6 human papillomavirus oncoprotein. Oncogene. 21: 5940-5. PMID 12185595 DOI: 10.1038/Sj.Onc.1205762  0.313
2002 Shou J, Ali-Osman F, Multani AS, Pathak S, Fedi P, Srivenugopal KS. Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA. Oncogene. 21: 878-89. PMID 11840333 DOI: 10.1038/Sj.Onc.1205138  0.432
2001 Mohanam S, Jasti SL, Kondraganti SR, Chandrasekar N, Lakka SS, Kin Y, Fuller GN, Yung AW, Kyritsis AP, Dinh DH, Olivero WC, Gujrati M, Ali-Osman F, Rao JS. Down-regulation of cathepsin B expression impairs the invasive and tumorigenic potential of human glioblastoma cells. Oncogene. 20: 3665-73. PMID 11439329 DOI: 10.1038/Sj.Onc.1204480  0.359
2001 Buckner JC, Moynihan TJ, Quinn DI, Schlegel U, Ali-Osman F, Srivenugopal K, Sawaya RE, Esteller M, Herman JG, Weinstein JN. The DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents [1] (multiple letters) The New England Journal of Medicine. 344: 686-688. PMID 11229336 DOI: 10.1056/Nejm200103013440914  0.315
2000 Lakka SS, Jasti SL, Kyritsis AP, Yung WK, Ali-Osman F, Nicolson GL, Rao JS. Regulation of MMP-9 (type IV collagenase) production and invasiveness in gliomas by the extracellular signal-regulated kinase and jun amino-terminal kinase signaling cascades. Clinical & Experimental Metastasis. 18: 245-52. PMID 11315098 DOI: 10.1023/A:1006724826083  0.319
2000 Ramachandran S, Hoban PR, Ichii-Jones F, Pleasants L, Ali-Osman F, Lear JT, Smith AG, Bowers B, Jones PW, Fryer AA, Strange RC. Glutathione S-transferase GSTP1 and cyclin D1 genotypes: association with numbers of basal cell carcinomas in a patient subgroup at high-risk of multiple tumours. Pharmacogenetics. 10: 545-56. PMID 10975609 DOI: 10.1097/00008571-200008000-00008  0.347
2000 Antoun G, Baylin SB, Ali-Osman F. DNA methyltransferase levels and altered CpG methylation in the total genome and in the GSTP1 gene in human glioma cells transfected with sense and antisense DNA methyltransferase cDNA. Journal of Cellular Biochemistry. 77: 372-81. PMID 10760946 DOI: 10.1002/(Sici)1097-4644(20000601)77:3<372::Aid-Jcb3>3.0.Co;2-P  0.377
2000 MULLAPUDI SRS, ALI-OSMAN F, SHOU J, SRIVENUGOPAL KS. DNA repair protein O6-alkylguanine-DNA alkyltransferase is phosphorylated by two distinct and novel protein kinases in human brain tumour cells Biochemical Journal. 351: 393-402. DOI: 10.1042/Bj3510393  0.327
1999 Multani AS, Ozen M, Sen S, Mandal AK, Price JE, Fan D, Radinsky R, Ali-Osman F, Von Eschenbach AC, Fidler IJ, Pathak S. Amplification of telomeric DNA directly correlates with metastatic potential of human and murine cancers of various histological origin. International Journal of Oncology. 15: 423-9. PMID 10427120 DOI: 10.3892/Ijo.15.3.423  0.356
1998 Keller C, Ali-Osman F. Translational inhibition of messenger RNA of the human pi class glutathione S-transferase by antisense oligodeoxyribonucleotides. Chemico-Biological Interactions. 111: 307-323. PMID 9679562 DOI: 10.1016/S0009-2797(97)00168-3  0.322
1998 Lo HW, Ali-Osman F. Structure of the human allelic glutathione S-transferase-pi gene variant, hGSTP1 C, cloned from a glioblastoma multiforme cell line. Chemico-Biological Interactions. 111: 91-102. PMID 9679546 DOI: 10.1016/S0009-2797(97)00153-1  0.63
1998 Anderson CM, Buzaid AC, Sussman J, Lee JJ, Ali-Osman F, Braunschweiger PG, Plager C, Bedikian A, Papadopoulos N, Eton O, Legha SS, Grimm EA. Nitric oxide and neopterin levels and clinical response in stage iii melanoma patients receiving concurrent biochemotherapy Melanoma Research. 8: 149-155. PMID 9610868 DOI: 10.1097/00008390-199804000-00008  0.322
1997 Srivenugopal KS, Ali-Osman F. Coordinate up-regulation of cyclin-dependent kinase 4 and its inhibitor p16(INK4) in human glioma cells following chloroethylnitrosourea-induced DNA damage. International Journal of Oncology. 11: 1251-1256. PMID 21528331 DOI: 10.3892/Ijo.11.6.1251  0.407
1997 Lo HW, Ali-Osman F. Genomic cloning of hGSTP1*C, an allelic human Pi class glutathione S-transferase gene variant and functional characterization of its retinoic acid response elements. The Journal of Biological Chemistry. 272: 32743-9. PMID 9407047 DOI: 10.1074/Jbc.272.52.32743  0.616
1997 Srivenugopal KS, Ali-Osman F. Activity and distribution of the cysteine prodrug activating enzyme, 5-oxo-L-prolinase, in human normal and tumor tissues. Cancer Letters. 117: 105-111. PMID 9233839 DOI: 10.1016/S0304-3835(97)00210-3  0.316
1997 Go Y, Chintala SK, Rayford A, Gagercas E, Ali-Osman F, Venkaiah B, Sawaya R, Gokaslan Z, Nicolson GL, Rao JS. Cisplatin but not BCNU inhibits urokinase-type plasminogen activator levels in human glioblastoma cell lines in vitro. Clinical & Experimental Metastasis. 15: 447-52. PMID 9219734 DOI: 10.1023/A:1018462507706  0.394
1997 Ali-Osman F, Akande O, Antoun G, Mao JX, Buolamwini J. Molecular cloning, characterization, and expression in Escherichia coli of full-length cDNAs of three human glutathione S-transferase Pi gene variants: Evidence for differential catalytic activity of the encoded proteins Journal of Biological Chemistry. 272: 10004-10012. PMID 9092542 DOI: 10.1074/Jbc.272.15.10004  0.367
1997 Brandt TY, Ali-Osman F. Detection of DNA damage in transcriptionally active genes by RT-PCR and assessment of repair of cisplatin-induced damage in the glutathione S-transferase-pi gene in human glioblastoma cells. Toxicology and Applied Pharmacology. 143: 22-9. PMID 9073588 DOI: 10.1006/Taap.1996.8010  0.404
1996 Ali-Osman F. Culture of human normal brain and malignant brain tumors for cellular, molecular, and pharmacological studies. Methods in Molecular Medicine. 2: 63-80. PMID 21359734 DOI: 10.1385/0-89603-335-X:63  0.337
1996 Srivenugopal KS, Yuan XH, Friedman HS, Ali-Osman F. Ubiquitination-dependent proteolysis of O6-methylguanine-DNA methyltransferase in human and murine tumor cells following inactivation with O6-benzylguanine or 1,3-bis(2-chloroethyl)-1-nitrosourea. Biochemistry. 35: 1328-34. PMID 8573590 DOI: 10.1021/Bi9518205  0.325
1996 Dong Q, Bullock N, Ali-Osman F, Colvin OM, Bigner DD, Friedman HS. Repair analysis of 4-hydroperoxycyclophosphamide-induced DNA interstrand crosslinking in the c-myc gene in 4-hydroperoxycyclophosphamide-sensitive and -resistant medulloblastoma cell lines. Cancer Chemotherapy and Pharmacology. 37: 242-46. PMID 8529284 DOI: 10.1007/Bf00688323  0.36
1995 Aggarwal BB, Pocsik E, Totpal K, Ali-Osman F. Suppression of antiproliferative effects of tumor necrosis factor by transfection of cells with human platelet-derived growth factor B/c-sis gene. Febs Letters. 357: 1-6. PMID 8001667 DOI: 10.1016/0014-5793(94)01299-G  0.383
1995 Li L, Yoo H, Becker FF, Ali-Osman F, Chan JY. Identification of a brain- and reproductive-organs-specific gene responsive to DNA damage and retinoic acid. Biochemical and Biophysical Research Communications. 206: 764-74. PMID 7826398 DOI: 10.1006/Bbrc.1995.1108  0.379
1994 Ali-Osman F, Berger MS, Rairkar A, Stein DE. Enhanced repair of a cisplatin-damaged reporter chloramphenicol-O-acetyltransferase gene and altered activities of DNA polymerases alpha and beta, and DNA ligase in cells of a human malignant glioma following in vivo cisplatin therapy. Journal of Cellular Biochemistry. 54: 11-9. PMID 8126081 DOI: 10.1002/Jcb.240540103  0.373
1994 Yoshida M, Khokhar AR, Kido Y, Ali-Osman F, Siddik ZH. Correlation of total and interstrand DNA adducts in tumor and kidney with antitumor efficacies and differential nephrotoxicities of cis-ammine/cyclohexylamine-dichloroplatinum(II) and cisplatin Biochemical Pharmacology. 48: 793-799. PMID 8080453 DOI: 10.1016/0006-2952(94)90058-2  0.337
1994 Pocsik E, Mihalik R, Ali-Osman F, Aggarwal BB. Cell density-dependent regulation of cell surface expression of two types of human tumor necrosis factor receptors and its effect on cellular response. Journal of Cellular Biochemistry. 54: 453-64. PMID 8014194 DOI: 10.1002/Jcb.240540412  0.349
1994 Rao JS, Steck PA, Tofilon P, Boyd D, Ali-Osman F, Stetler-Stevenson WG, Liotta LA, Sawaya R. Role of plasminogen activator and of 92-KDa type IV collagenase in glioblastoma invasion using an in vitro matrigel model. Journal of Neuro-Oncology. 18: 129-38. PMID 7964975 DOI: 10.1007/Bf01050419  0.337
1994 Aggarwal BB, Pocsik E, Ali-Osman F, Totpal K. Transfection of cells with transforming growth factor-alpha leads to cellular resistance to the antiproliferative effects of tumor necrosis factor. Febs Letters. 354: 12-6. PMID 7957892 DOI: 10.1016/0014-5793(94)01073-0  0.349
1994 Aggarwal BB, Totpal K, Ali-Osman F, Budde RJ, Pocsik E. pp60v-src kinase overexpression leads to cellular resistance to the antiproliferative effects of tumor necrosis factor. Febs Letters. 345: 219-24. PMID 7911089 DOI: 10.1016/0014-5793(94)00441-2  0.351
1994 Buzald AC, Grimm EA, Ali-Osman F, Ring S, Eton O, Papadopoulos NE, Bedikian A, Plager C, Legha SS, Benjamin R. Mechanism of the anti-tumour effect of biochemotherapy in melanoma: Preliminary results Melanoma Research. 4: 327-330. PMID 7858418 DOI: 10.1097/00008390-199410000-00010  0.317
1990 Sriram R, Ali-Osman F. S1-nuclease enhancement of the ethidium bromide binding assay of drug-induced DNA interstrand crosslinking in human brain tumor cells☆ Analytical Biochemistry. 187: 345-348. PMID 2200310 DOI: 10.1016/0003-2697(90)90467-N  0.304
1987 Ali-Osman F, Caughlin J, Berger M, Spence A, Spence A. PRIMARY CULTURES OF HUMAN GLIAL TUMOR CELLS AND THEIR RELATIONSHIP TO HISTOPATHOLOGY Journal of Neuropathology and Experimental Neurology. 46: 371. DOI: 10.1097/00005072-198705000-00126  0.303
1983 Ali-Osman F, Maurer HR. Stimulation of clonal tumor cell growth in vitro by inhibiting the serum polyamine oxidase activity. Journal of Cancer Research and Clinical Oncology. 106: 17-20. PMID 6885895 DOI: 10.1007/Bf00399892  0.359
1980 Ali-Osman F, Maurer HR. Comparison of cytostatic sensitivities of L 1210 cells and human stimulated lymphocytes in three cell proliferation assays. Journal of Cancer Research and Clinical Oncology. 98: 221-231. PMID 6453124 DOI: 10.1007/Bf00410786  0.322
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