| Year |
Citation |
Score |
| 2022 |
Sun Y, Li Q, Kirkland JL. Targeting senescent cells for a healthier longevity: the roadmap for an era of global aging. Life Medicine. 1: 103-119. PMID 36699942 DOI: 10.1093/lifemedi/lnac030 |
0.302 |
|
| 2022 |
Palmer AK, Tchkonia T, Kirkland JL. Targeting cellular senescence in metabolic disease. Molecular Metabolism. 101601. PMID 36116755 DOI: 10.1016/j.molmet.2022.101601 |
0.306 |
|
| 2020 |
Hall BM, Gleiberman AS, Strom E, Krasnov PA, Frescas D, Vujcic S, Leontieva OV, Antoch MP, Kogan V, Koman IE, Zhu Y, Tchkonia T, Kirkland JL, Chernova OB, Gudkov AV. Immune checkpoint protein VSIG4 as a biomarker of aging in murine adipose tissue. Aging Cell. e13219. PMID 32856419 DOI: 10.1111/Acel.13219 |
0.435 |
|
| 2020 |
Iske J, Seyda M, Heinbokel T, Maenosono R, Minami K, Nian Y, Quante M, Falk CS, Azuma H, Martin F, Passos JF, Niemann CU, Tchkonia T, Kirkland JL, Elkhal A, et al. Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation. Nature Communications. 11: 4289. PMID 32855397 DOI: 10.1038/S41467-020-18039-X |
0.314 |
|
| 2020 |
Wissler Gerdes EO, Zhu Y, Weigand BM, Tripathi U, Burns TC, Tchkonia T, Kirkland JL. Cellular senescence in aging and age-related diseases: Implications for neurodegenerative diseases. International Review of Neurobiology. 155: 203-234. PMID 32854855 DOI: 10.1016/Bs.Irn.2020.03.019 |
0.344 |
|
| 2020 |
Kirkland JL, Tchkonia T. Senolytic Drugs: From Discovery to Translation. Journal of Internal Medicine. PMID 32686219 DOI: 10.1111/Joim.13141 |
0.349 |
|
| 2020 |
Kim SR, Zou X, Tang H, Puranik AS, Abumoawad AM, Zhu XY, Hickson LJ, Tchkonia T, Textor SC, Kirkland JL, Lerman LO. Increased cellular senescence in the murine and human stenotic kidney: Effect of mesenchymal stem cells. Journal of Cellular Physiology. PMID 32657444 DOI: 10.1002/Jcp.29940 |
0.309 |
|
| 2020 |
Pignolo RJ, Passos JF, Khosla S, Tchkonia T, Kirkland JL. Reducing Senescent Cell Burden in Aging and Disease. Trends in Molecular Medicine. 26: 630-638. PMID 32589933 DOI: 10.1016/J.Molmed.2020.03.005 |
0.392 |
|
| 2020 |
Song S, Lam EW, Tchkonia T, Kirkland JL, Sun Y. Senescent Cells: Emerging Targets for Human Aging and Age-Related Diseases. Trends in Biochemical Sciences. 45: 578-592. PMID 32531228 DOI: 10.1016/J.Tibs.2020.03.008 |
0.402 |
|
| 2020 |
Conley SM, Hickson LJ, Kellogg TA, McKenzie T, Heimbach JK, Taner T, Tang H, Jordan KL, Saadiq IM, Woollard JR, Isik B, Afarideh M, Tchkonia T, Kirkland JL, Lerman LO. Human Obesity Induces Dysfunction and Early Senescence in Adipose Tissue-Derived Mesenchymal Stromal/Stem Cells. Frontiers in Cell and Developmental Biology. 8: 197. PMID 32274385 DOI: 10.3389/Fcell.2020.00197 |
0.352 |
|
| 2020 |
Kim SR, Jiang K, Ferguson CM, Tang H, Chen XJ, Zhu XY, Hickson LJ, Tchkonia T, Kirkland JL, Lerman LO. Transplanted senescent renal scattered tubular-like cells induce injury in the mouse kidney. American Journal of Physiology. Renal Physiology. PMID 32223312 DOI: 10.1152/Ajprenal.00535.2019 |
0.309 |
|
| 2020 |
Khosla S, Farr JN, Tchkonia T, Kirkland JL. The role of cellular senescence in ageing and endocrine disease. Nature Reviews. Endocrinology. PMID 32161396 DOI: 10.1038/S41574-020-0335-Y |
0.367 |
|
| 2020 |
Wissler Gerdes EO, Zhu Y, Tchkonia T, Kirkland JL. Discovery, Development, and Future Application of Senolytics: Theories and Predictions. The Febs Journal. PMID 32112672 DOI: 10.1111/Febs.15264 |
0.36 |
|
| 2020 |
Wang B, Liu Z, Chen VP, Wang L, Inman CL, Zhou Y, Guo C, Tchkonia T, Rowe DW, Kuchel GA, Robson P, Kirkland JL, Xu M. Transplanting cells from old but not young donors causes physical dysfunction in older recipients. Aging Cell. e13106. PMID 31971661 DOI: 10.1111/Acel.13106 |
0.323 |
|
| 2019 |
Newman AB, Kritchevsky SB, Guralnik JM, Cummings SR, Salive M, Kuchel GA, Schrack J, Morris MC, Weir D, Baccarelli A, Murabito JM, Ben-Shlomo Y, Espeland MA, Kirkland J, Melzer D, et al. Accelerating the Search for Interventions Aimed at Expanding the Health Span in Humans: The Role of Epidemiology. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. PMID 31722007 DOI: 10.1093/Gerona/Glz230 |
0.314 |
|
| 2019 |
Hickson LJ, Langhi Prata LGP, Bobart SA, Evans TK, Giorgadze N, Hashmi SK, Herrmann SM, Jensen MD, Jia Q, Jordan KL, Kellogg TA, Khosla S, Koerber DM, Lagnado AB, Lawson DK, ... ... Kirkland JL, et al. Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease. Ebiomedicine. PMID 31542391 DOI: 10.1016/J.Ebiom.2019.08.069 |
0.326 |
|
| 2019 |
Palmer AK, Gustafson B, Kirkland JL, Smith U. Cellular senescence: at the nexus between ageing and diabetes. Diabetologia. 62: 1835-1841. PMID 31451866 DOI: 10.1007/S00125-019-4934-X |
0.333 |
|
| 2019 |
Kim SR, Jiang K, Ogrodnik M, Chen X, Zhu XY, Lohmeier H, Ahmed L, Tang H, Tchkonia T, Hickson LJ, Kirkland JL, Lerman LO. Increased renal cellular senescence in murine high-fat diet: effect of the senolytic drug quercetin. Translational Research : the Journal of Laboratory and Clinical Medicine. PMID 31356770 DOI: 10.1016/J.Trsl.2019.07.005 |
0.325 |
|
| 2019 |
Prata LGPL, Ovsyannikova IG, Tchkonia T, Kirkland JL. Senescent cell clearance by the immune system: Emerging therapeutic opportunities. Seminars in Immunology. PMID 31088710 DOI: 10.1016/J.Smim.2019.04.003 |
0.322 |
|
| 2019 |
Miller BF, Pharaoh GA, Hamilton KL, Peelor FF, Kirkland JL, Freeman WM, Mann SN, Kinter M, Price JC, Stout MB. Short-term calorie restriction and 17α-estradiol administration elicit divergent effects on proteostatic processes and protein content in metabolically active tissues. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. PMID 31074767 DOI: 10.1093/Gerona/Glz113 |
0.318 |
|
| 2019 |
Chini C, Hogan KA, Warner GM, Tarragó MG, Peclat TR, Tchkonia T, Kirkland JL, Chini E. The NADase CD38 is induced by factors secreted from senescent cells providing a potential link between senescence and age-related cellular NAD decline. Biochemical and Biophysical Research Communications. PMID 30975470 DOI: 10.1016/J.Bbrc.2019.03.199 |
0.352 |
|
| 2019 |
Farr J, Rowsey J, Eckhardt B, Thicke B, Fraser D, Tchkonia T, Kirkland J, Monroe D, Khosla S. Independent Roles of Estrogen Deficiency and Cellular Senescence in the Pathogenesis of Osteoporosis: Evidence in Young Adult Mice and Older Humans. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. PMID 30913313 DOI: 10.1002/Jbmr.3729 |
0.333 |
|
| 2019 |
Palmer AK, Xu M, Zhu Y, Pirtskhalava T, Weivoda MM, Hachfeld CM, Prata LG, van Dijk TH, Verkade E, Casaclang-Verzosa G, Johnson KO, Cubro H, Doornebal EJ, Ogrodnik M, Jurk D, ... ... Kirkland JL, et al. Targeting senescent cells alleviates obesity-induced metabolic dysfunction. Aging Cell. e12950. PMID 30907060 DOI: 10.1111/Acel.12950 |
0.401 |
|
| 2019 |
Lewis-McDougall FC, Ruchaya PJ, Domenjo-Vila E, Shin Teoh T, Prata L, Cottle BJ, Clark JE, Punjabi PP, Awad W, Torella D, Tchkonia T, Kirkland JL, Ellison-Hughes GM. Aged-senescent cells contribute to impaired heart regeneration. Aging Cell. e12931. PMID 30854802 DOI: 10.1111/Acel.12931 |
0.39 |
|
| 2019 |
Tchkonia T, Kirkland JL. Therapeutic Approaches to Aging-Reply. Jama. 321: 901-902. PMID 30835305 DOI: 10.1001/Jama.2018.20554 |
0.31 |
|
| 2019 |
Anderson R, Lagnado A, Maggiorani D, Walaszczyk A, Dookun E, Chapman J, Birch J, Salmonowicz H, Ogrodnik M, Jurk D, Proctor C, Correia-Melo C, Victorelli S, Fielder E, Berlinguer-Palmini R, ... ... Kirkland JL, et al. Length-independent telomere damage drives post-mitotic cardiomyocyte senescence. The Embo Journal. PMID 30737259 DOI: 10.15252/Embj.2018100492 |
0.405 |
|
| 2019 |
Hurria A, Carpenter CR, McFarland F, Lundebjerg NE, de Cabo R, Ferrucci L, Studenski SA, Barzilai N, Briggs JP, Ix JH, Kitzman DW, Kuchel GA, Musi N, Newman JC, Rando TA, ... ... Kirkland JL, et al. Models and Studies of Aging: Executive Summary of a Report from the U13 Conference Series. Journal of the American Geriatrics Society. PMID 30693953 DOI: 10.1111/Jgs.15788 |
0.35 |
|
| 2019 |
Sah RP, Sharma A, Nagpal S, Patlolla SH, Sharma A, Kandlakunta H, Anani V, Angom RS, Kamboj A, Ahmed N, Mohapatra S, Vivekanandan S, Philbrick KA, Weston A, Takahashi N, ... Kirkland J, et al. Phases of Metabolic and Soft Tissue Changes in Months Preceding a Diagnosis of Pancreatic Ductal Adenocarcinoma. Gastroenterology. PMID 30677401 DOI: 10.1053/J.Gastro.2019.01.039 |
0.355 |
|
| 2019 |
Justice JN, Nambiar AM, Tchkonia T, LeBrasseur NK, Pascual R, Hashmi SK, Prata L, Masternak MM, Kritchevsky SB, Musi N, Kirkland JL. Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study. Ebiomedicine. PMID 30616998 DOI: 10.1016/J.Ebiom.2018.12.052 |
0.325 |
|
| 2019 |
Lau A, Kennedy BK, Kirkland JL, Tullius SG. Mixing old and young: enhancing rejuvenation and accelerating aging. The Journal of Clinical Investigation. 129: 4-11. PMID 30601138 DOI: 10.1172/Jci123946 |
0.334 |
|
| 2019 |
Justice JN, Nambiar AM, Tchkonia T, LeBrasseur NK, Musi N, Kritchevsky SB, Kirkland JL. CELLULAR SENESCENCE AS A THERAPEUTIC TARGET FOR GEROSCIENCE-GUIDED CLINICAL TRIALS Innovation in Aging. 3: S811-S811. DOI: 10.1093/Geroni/Igz038.2987 |
0.367 |
|
| 2018 |
Ogrodnik M, Zhu Y, Langhi LGP, Tchkonia T, Krüger P, Fielder E, Victorelli S, Ruswhandi RA, Giorgadze N, Pirtskhalava T, Podgorni O, Enikolopov G, Johnson KO, Xu M, Inman C, ... ... Kirkland JL, et al. Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis. Cell Metabolism. PMID 30612898 DOI: 10.1016/J.Cmet.2018.12.008 |
0.39 |
|
| 2018 |
Parikh P, Britt RD, Manlove LJ, Wicher SA, Roesler A, Ravix J, Teske J, Thompson MA, Sieck GC, Kirkland JL, LeBrasseur N, Tschumperlin DJ, Pabelick CM, Prakash YS. Hyperoxia-Induced Cellular Senescence in Fetal Airway Smooth Muscle Cells. American Journal of Respiratory Cell and Molecular Biology. PMID 30508396 DOI: 10.1165/Rcmb.2018-0176Oc |
0.314 |
|
| 2018 |
Rocca WA, Gazzuola Rocca L, Smith CY, Grossardt BR, Faubion SS, Shuster LT, Kirkland JL, LeBrasseur NK, Schafer MJ, Mielke MM, Kantarci K, Stewart EA, Miller VM. Loss of Ovarian Hormones and Accelerated Somatic and Mental Aging. Physiology (Bethesda, Md.). 33: 374-383. PMID 30303778 DOI: 10.1152/Physiol.00024.2018 |
0.33 |
|
| 2018 |
Yousefzadeh MJ, Zhu Y, McGowan SJ, Angelini L, Fuhrmann-Stroissnigg H, Xu M, Ling YY, Melos KI, Pirtskhalava T, Inman CL, McGuckian C, Wade EA, Kato JI, Grassi D, Wentworth M, ... ... Kirkland JL, et al. Fisetin is a senotherapeutic that extends health and lifespan. Ebiomedicine. PMID 30279143 DOI: 10.1016/J.Ebiom.2018.09.015 |
0.368 |
|
| 2018 |
Tchkonia T, Kirkland JL. Aging, Cell Senescence, and Chronic Disease: Emerging Therapeutic Strategies. Jama. 320: 1319-1320. PMID 30242336 DOI: 10.1001/Jama.2018.12440 |
0.335 |
|
| 2018 |
Nath KA, O'Brien DR, Croatt AJ, Grande JP, Ackerman AW, Nath MC, Yamada S, Terzic A, Tchkonia T, Kirkland JL, Katusic ZS. The Murine Dialysis Fistula Model Exhibits a Senescence Phenotype: Pathobiologic Mechanisms and Therapeutic Potential. American Journal of Physiology. Renal Physiology. PMID 30019935 DOI: 10.1152/Ajprenal.00308.2018 |
0.307 |
|
| 2018 |
Xu M, Pirtskhalava T, Farr JN, Weigand BM, Palmer AK, Weivoda MM, Inman CL, Ogrodnik MB, Hachfeld CM, Fraser DG, Onken JL, Johnson KO, Verzosa GC, Langhi LGP, Weigl M, ... ... Kirkland JL, et al. Senolytics improve physical function and increase lifespan in old age. Nature Medicine. PMID 29988130 DOI: 10.1038/S41591-018-0092-9 |
0.391 |
|
| 2018 |
Ness KK, Kirkland JL, Gramatges MM, Wang Z, Kundu M, McCastlain K, Li-Harms X, Zhang J, Tchkonia T, Pluijm SMF, Armstrong GT. Premature Physiologic Aging as a Paradigm for Understanding Increased Risk of Adverse Health Across the Lifespan of Survivors of Childhood Cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. JCO2017767467. PMID 29874132 DOI: 10.1200/Jco.2017.76.7467 |
0.315 |
|
| 2018 |
Hadley EC, Kuchel GA, Newman AB, Allore HG, Bartley JM, Bergeman CS, Blinov ML, Colon-Emeric CS, Dabhar FS, Dugan LL, Dutta C, Eldadah BA, Ferrucci L, Kirkland JL, Kritchevsky SB, et al. Report: NIA Workshop on Measures of Physiologic Resiliencies in Human Aging. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. PMID 29788088 DOI: 10.1093/Gerona/Glx172 |
0.32 |
|
| 2018 |
Khosla S, Farr JN, Kirkland JL. Inhibiting Cellular Senescence: A New Therapeutic Paradigm for Age-Related Osteoporosis. The Journal of Clinical Endocrinology and Metabolism. PMID 29425296 DOI: 10.1210/Jc.2017-02694 |
0.363 |
|
| 2017 |
Kirkland JL, Tchkonia T, Zhu Y, Niedernhofer LJ, Robbins PD. The Clinical Potential of Senolytic Drugs. Journal of the American Geriatrics Society. PMID 28869295 DOI: 10.1111/Jgs.14969 |
0.378 |
|
| 2017 |
Farr JN, Xu M, Weivoda MM, Monroe DG, Fraser DG, Onken JL, Negley BA, Sfeir JG, Ogrodnik MB, Hachfeld CM, LeBrasseur NK, Drake MT, Pignolo RJ, Pirtskhalava T, Tchkonia T, ... ... Kirkland JL, et al. Targeting cellular senescence prevents age-related bone loss in mice. Nature Medicine. PMID 28825716 DOI: 10.1038/Nm.4385 |
0.348 |
|
| 2017 |
Moncsek A, Al-Suraih MS, Trussoni CE, O'Hara SP, Splinter PL, Zuber C, Patsenker E, Valli PV, Fingas CD, Weber A, Zhu Y, Tchkonia T, Kirkland JL, Gores GJ, Müllhaupt B, et al. Targeting senescent cholangiocytes and activated fibroblasts with Bcl-xL inhibitors ameliorates fibrosis in Mdr2(-/-) mice. Hepatology (Baltimore, Md.). PMID 28802066 DOI: 10.1002/Hep.29464 |
0.333 |
|
| 2017 |
Justice JN, Gregory H, Tchkonia T, LeBrasseur NK, Kirkland JL, Kritchevsky SB, Nicklas BJ. Cellular senescence biomarker p16INK4a+ cell burden in thigh adipose is associated with poor physical function in older women. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. PMID 28658942 DOI: 10.1093/Gerona/Glx134 |
0.361 |
|
| 2017 |
Ogrodnik M, Miwa S, Tchkonia T, Tiniakos D, Wilson CL, Lahat A, Day CP, Burt A, Palmer A, Anstee QM, Grellscheid SN, Hoeijmakers JHJ, Barnhoorn S, Mann DA, Bird TG, ... ... Kirkland JL, et al. Cellular senescence drives age-dependent hepatic steatosis. Nature Communications. 8: 15691. PMID 28608850 DOI: 10.1038/Ncomms15691 |
0.426 |
|
| 2017 |
Kirkland JL, Tchkonia T. Cellular Senescence: A Translational Perspective. Ebiomedicine. PMID 28416161 DOI: 10.1016/J.Ebiom.2017.04.013 |
0.402 |
|
| 2017 |
Rocca WA, Gazzuola Rocca L, Smith CY, Grossardt BR, Faubion SS, Shuster LT, Kirkland JL, Stewart EA, Miller VM. Bilateral Oophorectomy and Accelerated Aging: Cause or Effect? The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. PMID 28329133 DOI: 10.1093/Gerona/Glx026 |
0.334 |
|
| 2017 |
Zhu Y, Doornebal EJ, Pirtskhalava T, Giorgadze N, Wentworth M, Fuhrmann-Stroissnigg H, Niedernhofer LJ, Robbins PD, Tchkonia T, Kirkland JL. New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463. Aging. PMID 28273655 DOI: 10.18632/Aging.101202 |
0.329 |
|
| 2017 |
Stout MB, Justice JN, Nicklas BJ, Kirkland JL. Physiological Aging: Links Among Adipose Tissue Dysfunction, Diabetes, and Frailty. Physiology (Bethesda, Md.). 32: 9-19. PMID 27927801 DOI: 10.1152/Physiol.00012.2016 |
0.443 |
|
| 2017 |
Kuipers F, Kirkland JL, Rooij SEd. Keynote: What Could Come From Understanding The Biology Of Aging? Innovation in Aging. 1: 1081-1082. DOI: 10.1093/Geroni/Igx004.3966 |
0.338 |
|
| 2017 |
Kirkland JL. Cellular Senescence: At the Nexus of Mechanisms of Age- and Obesity-Related Metabolic Dysfunction Free Radical Biology and Medicine. 108: S11. DOI: 10.1016/J.Freeradbiomed.2017.04.066 |
0.416 |
|
| 2016 |
Niedernhofer LJ, Kirkland JL, Ladiges W. MOLECULAR PATHOLOGY ENDPOINTS USEFUL FOR AGING STUDIES. Ageing Research Reviews. PMID 27721062 DOI: 10.1016/J.Arr.2016.09.012 |
0.309 |
|
| 2016 |
Huffman DM, Justice JN, Stout MB, Kirkland JL, Barzilai N, Austad SN. Evaluating Health Span in Preclinical Models of Aging and Disease: Guidelines, Challenges, and Opportunities for Geroscience. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. PMID 27535967 DOI: 10.1093/Gerona/Glw106 |
0.334 |
|
| 2016 |
Justice J, Miller JD, Newman JC, Hashmi SK, Halter J, Austad SN, Barzilai N, Kirkland JL. Frameworks for Proof-of-Concept Clinical Trials of Interventions That Target Fundamental Aging Processes. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. PMID 27535966 DOI: 10.1093/Gerona/Glw126 |
0.307 |
|
| 2016 |
Burd CE, Gill MS, Niedernhofer LJ, Robbins PD, Austad SN, Barzilai N, Kirkland JL. Barriers to the Preclinical Development of Therapeutics that Target Aging Mechanisms. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. PMID 27535964 DOI: 10.1093/Gerona/Glw112 |
0.301 |
|
| 2016 |
Kirkland JL, Stout MB, Sierra F. Resilience in Aging Mice. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. PMID 27535963 DOI: 10.1093/Gerona/Glw086 |
0.353 |
|
| 2016 |
Farr JN, Fraser DG, Wang H, Jaehn K, Ogrodnik MB, Weivoda MM, Drake MT, Tchkonia T, LeBrasseur NK, Kirkland JL, Bonewald LF, Pignolo RJ, Monroe DG, Khosla S. Identification of Senescent Cells in the Bone Microenvironment. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. PMID 27341653 DOI: 10.1002/Jbmr.2892 |
0.397 |
|
| 2016 |
Xu M, Tchkonia T, Kirkland JL. Perspective: Targeting the JAK/STAT pathway to fight age-related dysfunction. Pharmacological Research. PMID 27241018 DOI: 10.1016/J.Phrs.2016.05.015 |
0.427 |
|
| 2016 |
Schafer MJ, White TA, Evans G, Tonne JM, Verzosa GC, Stout MB, Mazula DL, Palmer AK, Baker DJ, Jensen MD, Torbenson MS, Miller JD, Ikeda Y, Tchkonia T, van Deursen JM, ... Kirkland JL, et al. Exercise Prevents Diet-induced Cellular Senescence in Adipose Tissue. Diabetes. PMID 26983960 DOI: 10.2337/Db15-0291 |
0.373 |
|
| 2016 |
Palmer AK, Kirkland JL. Aging and adipose tissue: potential interventions for diabetes and regenerative medicine. Experimental Gerontology. PMID 26924669 DOI: 10.1016/J.Exger.2016.02.013 |
0.44 |
|
| 2016 |
Stout MB, Steyn FJ, Jurczak MJ, Camporez JG, Zhu Y, Hawse JR, Jurk D, Palmer AK, Xu M, Pirtskhalava T, Evans GL, de Souza Santos R, Frank AP, White TA, Monroe DG, ... ... Kirkland JL, et al. 17α-Estradiol Alleviates Age-related Metabolic and Inflammatory Dysfunction in Male Mice Without Inducing Feminization. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. PMID 26809497 DOI: 10.1093/Gerona/Glv309 |
0.353 |
|
| 2015 |
Zhu Y, Tchkonia T, Fuhrmann-Stroissnigg H, Dai HM, Ling YY, Stout MB, Pirtskhalava T, Giorgadze N, Johnson KO, Giles CB, Wren JD, Niedernhofer LJ, Robbins PD, Kirkland JL. Identification of a Novel Senolytic Agent, Navitoclax, Targeting the Bcl-2 Family of Anti-Apoptotic Factors. Aging Cell. PMID 26711051 DOI: 10.1111/Acel.12445 |
0.305 |
|
| 2015 |
Xu M, Palmer AK, Ding H, Weivoda MM, Pirtskhalava T, White TA, Sepe A, Johnson KO, Stout MB, Giorgadze N, Jensen MD, LeBrasseur NK, Tchkonia T, Kirkland JL. Targeting senescent cells enhances adipogenesis and metabolic function in old age. Elife. 4. PMID 26687007 DOI: 10.7554/Elife.12997 |
0.498 |
|
| 2015 |
Xu M, Tchkonia T, Ding H, Ogrodnik M, Lubbers ER, Pirtskhalava T, White TA, Johnson KO, Stout MB, Mezera V, Giorgadze N, Jensen MD, LeBrasseur NK, Kirkland JL. JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age. Proceedings of the National Academy of Sciences of the United States of America. 112: E6301-E6310. PMID 26578790 DOI: 10.1073/Pnas.1515386112 |
0.438 |
|
| 2015 |
Comisford R, Lubbers ER, Householder LA, Suer O, Tchkonia T, Kirkland JL, List EO, Kopchick JJ, Berryman DE. Growth Hormone Receptor Antagonist Transgenic Mice Have Increased Subcutaneous Adipose Tissue Mass, Altered Glucose Homeostasis and No Change in White Adipose Tissue Cellular Senescence. Gerontology. PMID 26372907 DOI: 10.1159/000439050 |
0.375 |
|
| 2015 |
Palmer AK, Tchkonia T, LeBrasseur NK, Chini EN, Xu M, Kirkland JL. Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity. Diabetes. 64: 2289-98. PMID 26106186 DOI: 10.2337/Db14-1820 |
0.371 |
|
| 2015 |
Sagar G, Sah RP, Javeed N, Dutta SK, Smyrk TC, Lau JS, Giorgadze N, Tchkonia T, Kirkland JL, Chari ST, Mukhopadhyay D. Pathogenesis of pancreatic cancer exosome-induced lipolysis in adipose tissue. Gut. PMID 26061593 DOI: 10.1136/Gutjnl-2014-308350 |
0.305 |
|
| 2015 |
Stout MB, Tchkonia T, Kirkland JL. Growth hormone in adipose dysfunction and senescence. Oncotarget. 6: 10667-8. PMID 25951493 DOI: 10.18632/Oncotarget.3997 |
0.467 |
|
| 2015 |
Zhu Y, Tchkonia T, Stout MB, Giorgadze N, Wang L, Li PW, Heppelmann CJ, Bouloumié A, Jensen MD, Bergen HR, Kirkland JL. Inflammation and the depot-specific secretome of human preadipocytes. Obesity (Silver Spring, Md.). 23: 989-99. PMID 25864718 DOI: 10.1002/Oby.21053 |
0.369 |
|
| 2015 |
Zhu Y, Tchkonia T, Pirtskhalava T, Gower AC, Ding H, Giorgadze N, Palmer AK, Ikeno Y, Hubbard GB, Lenburg M, O'Hara SP, LaRusso NF, Miller JD, Roos CM, Verzosa GC, ... ... Kirkland JL, et al. The Achilles' heel of senescent cells: from transcriptome to senolytic drugs. Aging Cell. 14: 644-58. PMID 25754370 DOI: 10.1111/Acel.12344 |
0.381 |
|
| 2015 |
Kirkland JL, Tchkonia T. Clinical strategies and animal models for developing senolytic agents. Experimental Gerontology. 68: 19-25. PMID 25446976 DOI: 10.1016/J.Exger.2014.10.012 |
0.335 |
|
| 2015 |
Idrissova L, Malhi H, Werneburg NW, LeBrasseur NK, Bronk SF, Fingas C, Tchkonia T, Pirtskhalava T, White TA, Stout MB, Hirsova P, Krishnan A, Liedtke C, Trautwein C, Finnberg N, ... ... Kirkland JL, et al. TRAIL receptor deletion in mice suppresses the inflammation of nutrient excess. Journal of Hepatology. 62: 1156-63. PMID 25445398 DOI: 10.1016/J.Jhep.2014.11.033 |
0.306 |
|
| 2015 |
Santosa S, Swain J, Tchkonia T, Kirkland JL, Jensen MD. Inflammatory characteristics of adipose tissue collected by surgical excision vs needle aspiration. International Journal of Obesity (2005). 39: 874-6. PMID 25319743 DOI: 10.1038/Ijo.2014.185 |
0.338 |
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| 2015 |
Escande C, Nin V, Pirtskhalava T, Chini CC, Tchkonia T, Kirkland JL, Chini EN. Deleted in breast cancer 1 limits adipose tissue fat accumulation and plays a key role in the development of metabolic syndrome phenotype. Diabetes. 64: 12-22. PMID 25053585 DOI: 10.2337/Db14-0192 |
0.43 |
|
| 2015 |
Xu M, Palmer AK, Ding H, Weivoda MM, Pirtskhalava T, White TA, Sepe A, Johnson KO, Stout MB, Giorgadze N, Jensen MD, LeBrasseur NK, Tchkonia T, Kirkland JL. Author response: Targeting senescent cells enhances adipogenesis and metabolic function in old age Elife. DOI: 10.7554/Elife.12997.028 |
0.364 |
|
| 2014 |
Childs BG, Baker DJ, Kirkland JL, Campisi J, van Deursen JM. Senescence and apoptosis: dueling or complementary cell fates? Embo Reports. 15: 1139-53. PMID 25312810 DOI: 10.15252/Embr.201439245 |
0.361 |
|
| 2014 |
Tran D, Bergholz J, Zhang H, He H, Wang Y, Zhang Y, Li Q, Kirkland JL, Xiao ZX. Insulin-like growth factor-1 regulates the SIRT1-p53 pathway in cellular senescence. Aging Cell. 13: 669-78. PMID 25070626 DOI: 10.1111/Acel.12219 |
0.368 |
|
| 2014 |
Stout MB, Tchkonia T, Pirtskhalava T, Palmer AK, List EO, Berryman DE, Lubbers ER, Escande C, Spong A, Masternak MM, Oberg AL, LeBrasseur NK, Miller RA, Kopchick JJ, Bartke A, ... Kirkland JL, et al. Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice. Aging. 6: 575-86. PMID 25063774 |
0.34 |
|
| 2014 |
Escande C, Nin V, Pirtskhalava T, Chini CC, Thereza Barbosa M, Mathison A, Urrutia R, Tchkonia T, Kirkland JL, Chini EN. Deleted in Breast Cancer 1 regulates cellular senescence during obesity. Aging Cell. 13: 951-3. PMID 24992635 DOI: 10.1111/Acel.12235 |
0.366 |
|
| 2014 |
Zhu Y, Armstrong JL, Tchkonia T, Kirkland JL. Cellular senescence and the senescent secretory phenotype in age-related chronic diseases. Current Opinion in Clinical Nutrition and Metabolic Care. 17: 324-8. PMID 24848532 DOI: 10.1097/Mco.0000000000000065 |
0.334 |
|
| 2014 |
Wong S, Kirkland JL, Schwanz HA, Simmons AL, Hamilton JA, Corkey BE, Guo W. Effects of thiol antioxidant β-mercaptoethanol on diet-induced obese mice. Life Sciences. 107: 32-41. PMID 24802126 DOI: 10.1016/J.Lfs.2014.04.031 |
0.323 |
|
| 2014 |
Xu M, Stout M, Pirtskhalava T, Giorgadze N, White T, Jensen M, LeBrasseur N, Tchkonia T, Kirkland J. The bystander and systematic adverse effects of senescent preadipocytes (LB54) The Faseb Journal. 28. DOI: 10.1096/Fasebj.28.1_Supplement.Lb54 |
0.398 |
|
| 2013 |
Conover CA, Harstad SL, Tchkonia T, Kirkland JL. Preferential impact of pregnancy-associated plasma protein-A deficiency on visceral fat in mice on high-fat diet. American Journal of Physiology. Endocrinology and Metabolism. 305: E1145-53. PMID 24045868 DOI: 10.1152/Ajpendo.00405.2013 |
0.411 |
|
| 2013 |
Tchkonia T, Thomou T, Zhu Y, Karagiannides I, Pothoulakis C, Jensen MD, Kirkland JL. Mechanisms and metabolic implications of regional differences among fat depots. Cell Metabolism. 17: 644-56. PMID 23583168 DOI: 10.1016/J.Cmet.2013.03.008 |
0.783 |
|
| 2013 |
Neacsu O, Cleveland K, Xu H, Tchkonia TT, Kirkland JL, Boney CM. IGF-I attenuates FFA-induced activation of JNK1 phosphorylation and TNFα expression in human subcutaneous preadipocytes. Obesity (Silver Spring, Md.). 21: 1843-9. PMID 23512893 DOI: 10.1002/Oby.20329 |
0.373 |
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| 2013 |
Tchkonia T, Zhu Y, van Deursen J, Campisi J, Kirkland JL. Cellular senescence and the senescent secretory phenotype: therapeutic opportunities. The Journal of Clinical Investigation. 123: 966-72. PMID 23454759 DOI: 10.1172/Jci64098 |
0.358 |
|
| 2012 |
Mori MA, Raghavan P, Thomou T, Boucher J, Robida-Stubbs S, Macotela Y, Russell SJ, Kirkland JL, Blackwell TK, Kahn CR. Role of microRNA processing in adipose tissue in stress defense and longevity. Cell Metabolism. 16: 336-47. PMID 22958919 DOI: 10.1016/J.Cmet.2012.07.017 |
0.746 |
|
| 2012 |
Guo W, Li Y, Liang W, Wong S, Apovian C, Kirkland JL, Corkey BE. Beta-mecaptoethanol suppresses inflammation and induces adipogenic differentiation in 3T3-F442A murine preadipocytes. Plos One. 7: e40958. PMID 22911724 DOI: 10.1371/Journal.Pone.0040958 |
0.44 |
|
| 2011 |
Baker DJ, Wijshake T, Tchkonia T, LeBrasseur NK, Childs BG, van de Sluis B, Kirkland JL, van Deursen JM. Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature. 479: 232-6. PMID 22048312 DOI: 10.1038/Nature10600 |
0.435 |
|
| 2011 |
Karagiannides I, Bakirtzi K, Kokkotou E, Stavrakis D, Margolis KG, Thomou T, Giorgadze N, Kirkland JL, Pothoulakis C. Role of substance P in the regulation of glucose metabolism via insulin signaling-associated pathways. Endocrinology. 152: 4571-80. PMID 22009727 DOI: 10.1210/En.2011-1170 |
0.774 |
|
| 2011 |
Karagiannides I, Stavrakis D, Bakirtzi K, Kokkotou E, Pirtskhalava T, Nayeb-Hashemi H, Bowe C, Bugni JM, Nuño M, Lu B, Gerard NP, Leeman SE, Kirkland JL, Pothoulakis C. Substance P (SP)-neurokinin-1 receptor (NK-1R) alters adipose tissue responses to high-fat diet and insulin action. Endocrinology. 152: 2197-205. PMID 21467195 DOI: 10.1210/En.2010-1345 |
0.712 |
|
| 2011 |
Reichert B, Yasmeen R, Jeyakumar SM, Yang F, Thomou T, Alder H, Duester G, Maiseyeu A, Mihai G, Harrison EH, Rajagopalan S, Kirkland JL, Ziouzenkova O. Concerted action of aldehyde dehydrogenases influences depot-specific fat formation. Molecular Endocrinology (Baltimore, Md.). 25: 799-809. PMID 21436255 DOI: 10.1210/Me.2010-0465 |
0.74 |
|
| 2011 |
Schulz TJ, Huang TL, Tran TT, Zhang H, Townsend KL, Shadrach JL, Cerletti M, McDougall LE, Giorgadze N, Tchkonia T, Schrier D, Falb D, Kirkland JL, Wagers AJ, Tseng YH. Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat. Proceedings of the National Academy of Sciences of the United States of America. 108: 143-8. PMID 21173238 DOI: 10.1073/Pnas.1010929108 |
0.42 |
|
| 2011 |
Sepe A, Tchkonia T, Thomou T, Zamboni M, Kirkland JL. Aging and regional differences in fat cell progenitors - a mini-review. Gerontology. 57: 66-75. PMID 20110661 DOI: 10.1159/000279755 |
0.787 |
|
| 2010 |
Tchoukalova YD, Votruba SB, Tchkonia T, Giorgadze N, Kirkland JL, Jensen MD. Regional differences in cellular mechanisms of adipose tissue gain with overfeeding. Proceedings of the National Academy of Sciences of the United States of America. 107: 18226-31. PMID 20921416 DOI: 10.1073/Pnas.1005259107 |
0.417 |
|
| 2010 |
Villaret A, Galitzky J, Decaunes P, Estève D, Marques MA, Sengenès C, Chiotasso P, Tchkonia T, Lafontan M, Kirkland JL, Bouloumié A. Adipose tissue endothelial cells from obese human subjects: differences among depots in angiogenic, metabolic, and inflammatory gene expression and cellular senescence. Diabetes. 59: 2755-63. PMID 20713685 DOI: 10.2337/Db10-0398 |
0.383 |
|
| 2010 |
Tchkonia T, Morbeck DE, Von Zglinicki T, Van Deursen J, Lustgarten J, Scrable H, Khosla S, Jensen MD, Kirkland JL. Fat tissue, aging, and cellular senescence. Aging Cell. 9: 667-84. PMID 20701600 DOI: 10.1111/J.1474-9726.2010.00608.X |
0.484 |
|
| 2010 |
Cleveland-Donovan K, Maile LA, Tsiaras WG, Tchkonia T, Kirkland JL, Boney CM. IGF-I activation of the AKT pathway is impaired in visceral but not subcutaneous preadipocytes from obese subjects. Endocrinology. 151: 3752-63. PMID 20555032 DOI: 10.1210/En.2010-0043 |
0.37 |
|
| 2010 |
Zaragosi LE, Wdziekonski B, Villageois P, Keophiphath M, Maumus M, Tchkonia T, Bourlier V, Mohsen-Kanson T, Ladoux A, Elabd C, Scheideler M, Trajanoski Z, Takashima Y, Amri EZ, Lacasa D, ... ... Kirkland JL, et al. Activin a plays a critical role in proliferation and differentiation of human adipose progenitors. Diabetes. 59: 2513-21. PMID 20530742 DOI: 10.2337/Db10-0013 |
0.377 |
|
| 2010 |
Tchoukalova YD, Koutsari C, Votruba SB, Tchkonia T, Giorgadze N, Thomou T, Kirkland JL, Jensen MD. Sex- and depot-dependent differences in adipogenesis in normal-weight humans. Obesity (Silver Spring, Md.). 18: 1875-80. PMID 20300084 DOI: 10.1038/Oby.2010.56 |
0.736 |
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| 2010 |
Cartwright MJ, Schlauch K, Lenburg ME, Tchkonia T, Pirtskhalava T, Cartwright A, Thomou T, Kirkland JL. Aging, depot origin, and preadipocyte gene expression. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 65: 242-51. PMID 20106964 DOI: 10.1093/Gerona/Glp213 |
0.767 |
|
| 2009 |
Gross K, Karagiannides I, Thomou T, Koon HW, Bowe C, Kim H, Giorgadze N, Tchkonia T, Pirtskhalava T, Kirkland JL, Pothoulakis C. Substance P promotes expansion of human mesenteric preadipocytes through proliferative and antiapoptotic pathways. American Journal of Physiology. Gastrointestinal and Liver Physiology. 296: G1012-9. PMID 19282377 DOI: 10.1152/Ajpgi.90351.2008 |
0.772 |
|
| 2009 |
Kirkland JL, Peterson C. Healthspan, translation, and new outcomes for animal studies of aging. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 64: 209-12. PMID 19196900 DOI: 10.1093/Gerona/Gln063 |
0.312 |
|
| 2008 |
Gupta V, Bhasin S, Guo W, Singh R, Miki R, Chauhan P, Choong K, Tchkonia T, Lebrasseur NK, Flanagan JN, Hamilton JA, Viereck JC, Narula NS, Kirkland JL, Jasuja R. Effects of dihydrotestosterone on differentiation and proliferation of human mesenchymal stem cells and preadipocytes. Molecular and Cellular Endocrinology. 296: 32-40. PMID 18801408 DOI: 10.1016/J.Mce.2008.08.019 |
0.399 |
|
| 2008 |
Vitseva OI, Tanriverdi K, Tchkonia TT, Kirkland JL, McDonnell ME, Apovian CM, Freedman J, Gokce N. Inducible Toll-like receptor and NF-kappaB regulatory pathway expression in human adipose tissue. Obesity (Silver Spring, Md.). 16: 932-7. PMID 18292749 DOI: 10.1038/Oby.2008.25 |
0.388 |
|
| 2008 |
Guo W, Flanagan J, Jasuja R, Kirkland J, Jiang L, Bhasin S. The effects of myostatin on adipogenic differentiation of human bone marrow-derived mesenchymal stem cells are mediated through cross-communication between Smad3 and Wnt/beta-catenin signaling pathways. The Journal of Biological Chemistry. 283: 9136-45. PMID 18203713 DOI: 10.1074/Jbc.M708968200 |
0.33 |
|
| 2008 |
Karagiannidis I, Bakirtzi K, Thomou T, Bowe C, Gross K, Pirtskhalava T, Giorgadze N, Kirkland J, Pothoulakis C. W1753 Substance P Decreases Insulin-Induced Glucose Uptake in Adipocytes Gastroenterology. 134: A-708-A-709. DOI: 10.1016/S0016-5085(08)63308-9 |
0.71 |
|
| 2007 |
Tchkonia T, Pirtskhalava T, Thomou T, Cartwright MJ, Wise B, Karagiannides I, Shpilman A, Lash TL, Becherer JD, Kirkland JL. Increased TNFalpha and CCAAT/enhancer-binding protein homologous protein with aging predispose preadipocytes to resist adipogenesis. American Journal of Physiology. Endocrinology and Metabolism. 293: E1810-9. PMID 17911345 DOI: 10.1152/Ajpendo.00295.2007 |
0.8 |
|
| 2007 |
Guo W, Bigornia S, Leizerman I, Xie W, McDonnell M, Clemente K, Pirtskhalava T, Kirkland JL, Gokce N, Corkey BE, Sullivan LM, Apovian CM. New scanning electron microscopic method for determination of adipocyte size in humans and mice. Obesity (Silver Spring, Md.). 15: 1657-65. PMID 17636083 DOI: 10.1038/Oby.2007.198 |
0.348 |
|
| 2007 |
Han JR, Deng B, Sun J, Chen CG, Corkey BE, Kirkland JL, Ma J, Guo W. Effects of dietary medium-chain triglyceride on weight loss and insulin sensitivity in a group of moderately overweight free-living type 2 diabetic Chinese subjects. Metabolism: Clinical and Experimental. 56: 985-91. PMID 17570262 DOI: 10.1016/J.Metabol.2007.03.005 |
0.304 |
|
| 2007 |
Cartwright MJ, Tchkonia T, Kirkland JL. Aging in adipocytes: potential impact of inherent, depot-specific mechanisms. Experimental Gerontology. 42: 463-71. PMID 17507194 DOI: 10.1016/J.Exger.2007.03.003 |
0.468 |
|
| 2007 |
Guo W, Pirtskhalava T, Tchkonia T, Xie W, Thomou T, Han J, Wang T, Wong S, Cartwright A, Hegardt FG, Corkey BE, Kirkland JL. Aging results in paradoxical susceptibility of fat cell progenitors to lipotoxicity. American Journal of Physiology. Endocrinology and Metabolism. 292: E1041-51. PMID 17148751 DOI: 10.1152/Ajpendo.00557.2006 |
0.764 |
|
| 2007 |
Tchkonia T, Lenburg M, Thomou T, Giorgadze N, Frampton G, Pirtskhalava T, Cartwright A, Cartwright M, Flanagan J, Karagiannides I, Gerry N, Forse RA, Tchoukalova Y, Jensen MD, Pothoulakis C, ... Kirkland JL, et al. Identification of depot-specific human fat cell progenitors through distinct expression profiles and developmental gene patterns American Journal of Physiology - Endocrinology and Metabolism. 292: E298-E307. PMID 16985259 DOI: 10.1152/Ajpendo.00202.2006 |
0.785 |
|
| 2006 |
Tchkonia T, Giorgadze N, Pirtskhalava T, Thomou T, DePonte M, Koo A, Forse RA, Chinnappan D, Martin-Ruiz C, von Zglinicki T, Kirkland JL. Fat depot-specific characteristics are retained in strains derived from single human preadipocytes. Diabetes. 55: 2571-8. PMID 16936206 DOI: 10.2337/Db06-0540 |
0.755 |
|
| 2006 |
Karagiannides I, Thomou T, Tchkonia T, Pirtskhalava T, Kypreos KE, Cartwright A, Dalagiorgou G, Lash TL, Farmer SR, Timchenko NA, Kirkland JL. Increased CUG triplet repeat-binding protein-1 predisposes to impaired adipogenesis with aging. The Journal of Biological Chemistry. 281: 23025-33. PMID 16754681 DOI: 10.1074/Jbc.M513187200 |
0.784 |
|
| 2006 |
Xie W, Hamilton JA, Kirkland JL, Corkey BE, Guo W. Oleate-induced formation of fat cells with impaired insulin sensitivity. Lipids. 41: 267-71. PMID 16711601 DOI: 10.1007/S11745-006-5096-4 |
0.413 |
|
| 2006 |
Karagiannides I, Kokkotou E, Tansky M, Tchkonia T, Giorgadze N, O'Brien M, Leeman SE, Kirkland JL, Pothoulakis C. Induction of colitis causes inflammatory responses in fat depots: evidence for substance P pathways in human mesenteric preadipocytes. Proceedings of the National Academy of Sciences of the United States of America. 103: 5207-12. PMID 16549770 DOI: 10.1073/Pnas.0600821103 |
0.695 |
|
| 2005 |
Tchkonia T, Tchoukalova YD, Giorgadze N, Pirtskhalava T, Karagiannides I, Forse RA, Koo A, Stevenson M, Chinnappan D, Cartwright A, Jensen MD, Kirkland JL. Abundance of two human preadipocyte subtypes with distinct capacities for replication, adipogenesis, and apoptosis varies among fat depots. American Journal of Physiology. Endocrinology and Metabolism. 288: E267-77. PMID 15383371 DOI: 10.1152/Ajpendo.00265.2004 |
0.727 |
|
| 2003 |
Han J, Hamilton JA, Kirkland JL, Corkey BE, Guo W. Medium-chain oil reduces fat mass and down-regulates expression of adipogenic genes in rats. Obesity Research. 11: 734-44. PMID 12805394 DOI: 10.1038/Oby.2003.103 |
0.351 |
|
| 2002 |
Kirkland JL. The biology of senescence: potential for prevention of disease. Clinics in Geriatric Medicine. 18: 383-405. PMID 12424865 DOI: 10.1016/S0749-0690(02)00023-X |
0.396 |
|
| 2002 |
Kirkland JL, Tchkonia T, Pirtskhalava T, Han J, Karagiannides I. Adipogenesis and aging: does aging make fat go MAD? Experimental Gerontology. 37: 757-67. PMID 12175476 DOI: 10.1016/S0531-5565(02)00014-1 |
0.765 |
|
| 2002 |
Han J, Farmer SR, Kirkland JL, Corkey BE, Yoon R, Pirtskhalava T, Ido Y, Guo W. Octanoate attenuates adipogenesis in 3T3-L1 preadipocytes. The Journal of Nutrition. 132: 904-10. PMID 11983812 DOI: 10.1093/Jn/132.5.904 |
0.359 |
|
| 2002 |
Tchkonia T, Giorgadze N, Pirtskhalava T, Tchoukalova Y, Karagiannides I, Forse RA, DePonte M, Stevenson M, Guo W, Han J, Waloga G, Lash TL, Jensen MD, Kirkland JL. Fat depot origin affects adipogenesis in primary cultured and cloned human preadipocytes. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 282: R1286-96. PMID 11959668 DOI: 10.1152/Ajpregu.00653.2001 |
0.721 |
|
| 2001 |
Karagiannides I, Tchkonia T, Dobson DE, Steppan CM, Cummins P, Chan G, Salvatori K, Hadzopoulou-Cladaras M, Kirkland JL. Altered expression of C/EBP family members results in decreased adipogenesis with aging. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 280: R1772-80. PMID 11353682 DOI: 10.1152/Ajpregu.2001.280.6.R1772 |
0.74 |
|
| 2001 |
Caserta F, Tchkonia T, Civelek VN, Prentki M, Brown NF, McGarry JD, Forse RA, Corkey BE, Hamilton JA, Kirkland JL. Fat depot origin affects fatty acid handling in cultured rat and human preadipocytes American Journal of Physiology - Endocrinology and Metabolism. 280. PMID 11158926 DOI: 10.1152/Ajpendo.2001.280.2.E238 |
0.413 |
|
| 2001 |
Guo W, Choi JK, Kirkland JL, Corkey BE, Hamilton JA. Esterification of free fatty acids in adipocytes: a comparison between octanoate and oleate. The Biochemical Journal. 349: 463-71. PMID 10880345 DOI: 10.1042/0264-6021:3490463 |
0.391 |
|
| 2001 |
Tchkonia T, Karagiannides I, Forse RA, Kirkland JL. Different fat depots are distinct mini-organs Current Opinion in Endocrinology & Diabetes. 8: 227-234. DOI: 10.1097/00060793-200110000-00001 |
0.728 |
|
| 1999 |
Guo W, Choi JK, Kirkland JL, Corkey BE, Hamilton JA. Incorporation of [1-13C]oleate into cellular triglycerides in differentiating 3T3L1 cells. Lipids. 34: 825-31. PMID 10529093 DOI: 10.1007/S11745-999-0429-X |
0.355 |
|
| 1999 |
Kirkland JL. Commentary: aging, differentiation-dependent gene expression, and fat cell function. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 54: B189-90; discussion . PMID 10361997 DOI: 10.1093/Gerona/54.5.B189 |
0.423 |
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| 1999 |
Kirkland JL, Hollenberg CH. Inhibitors of preadipocyte replication: opportunities for the treatment of obesity. Progress in Molecular and Subcellular Biology. 20: 177-95. PMID 9928531 DOI: 10.1007/978-3-642-72149-6_9 |
0.353 |
|
| 1998 |
Guo W, Kirkland JL, Corkey B, Hamilton JA. A 13C nuclear magnetic resonance study of free fatty acid incorporation in acylated lipids in differentiating preadipocytes. Lipids. 33: 449-54. PMID 9625591 DOI: 10.1007/S11745-998-0227-5 |
0.302 |
|
| 1997 |
Kirkland JL, Dobson DE. Preadipocyte function and aging: links between age-related changes in cell dynamics and altered fat tissue function. Journal of the American Geriatrics Society. 45: 959-67. PMID 9256849 DOI: 10.1111/J.1532-5415.1997.Tb02967.X |
0.474 |
|
| 1996 |
McDermott GF, Ingram A, Scholey J, Kirkland JL, Whiteside CI. Glomerular dysfunction in the aging Fischer 344 rat is associated with excessive growth and normal mesangial cell function. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 51: M80-5. PMID 8612108 DOI: 10.1093/Gerona/51A.2.M80 |
0.324 |
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| 1994 |
Kirkland JL, Hollenberg CH, Kindler S, Gillon WS. Effects of Age and Anatomic Site on Preadipocyte Number in Rat Fat Depots The Journals of Gerontology. 49. PMID 8282974 DOI: 10.1093/Geronj/49.1.B31 |
0.427 |
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| 1994 |
Kirkland JL, Hollenberg CH, Gillon WS. Effects of aging on ribosomal protein L7 messenger RNA levels in cultured rat preadipocytes. Experimental Gerontology. 28: 557-63. PMID 8137892 DOI: 10.1016/0531-5565(93)90044-E |
0.334 |
|
| 1993 |
Kirkland JL, Hollenberg CH, Gillon WS. Two preadipocyte subtypes cloned from human omental fat. Obesity Research. 1: 87-91. PMID 16350564 DOI: 10.1002/J.1550-8528.1993.Tb00596.X |
0.36 |
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| 1993 |
Kirkland JL, Hollenberg CH, Gillon WS. Ageing, differentiation, and gene expression in rat epididymal preadipocytes Biochemistry and Cell Biology. 71: 556-561. PMID 8192892 DOI: 10.1139/O93-079 |
0.406 |
|
| 1992 |
Kirkland JL. The biochemistry of mammalian senescence Clinical Biochemistry. 25: 61-75. PMID 1623580 DOI: 10.1016/0009-9120(92)80047-K |
0.318 |
|
| 1992 |
Kirkland JL, Hollenberg CH, Gillon W, Kindler S. Effect of hypophysectomy on rat preadipocyte replication and differentiation. Endocrinology. 131: 2769-2773. PMID 1446615 DOI: 10.1210/Endo.131.6.1446615 |
0.354 |
|
| 1990 |
Kirkland JL, Hollenberg CH, Gillon WS. Age, anatomic site, and the replication and differentiation of adipocyte precursors. American Journal of Physiology-Cell Physiology. 258. PMID 2305864 DOI: 10.1152/Ajpcell.1990.258.2.C206 |
0.397 |
|
| 1989 |
Kirkland JL. Evolution and ageing Genome. 31: 398-405. PMID 2687105 DOI: 10.1139/G89-060 |
0.309 |
|
| 1984 |
Kirkland JL, Dax EM. Adipocyte hormone responsiveness and aging in the rat: problems in the interpretation of aging research. Journal of the American Geriatrics Society. 32: 219-28. PMID 6321584 DOI: 10.1111/J.1532-5415.1984.Tb02006.X |
0.416 |
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