| Year |
Citation |
Score |
| 2018 |
Kent SB. Racemic & quasi-racemic protein crystallography enabled by chemical protein synthesis. Current Opinion in Chemical Biology. 46: 1-9. PMID 29626784 DOI: 10.1016/j.cbpa.2018.03.012 |
0.335 |
|
| 2017 |
Kent S. Chemical protein synthesis: Inventing synthetic methods to decipher how proteins work. Bioorganic & Medicinal Chemistry. 25: 4926-4937. PMID 28687227 DOI: 10.1016/J.Bmc.2017.06.020 |
0.477 |
|
| 2017 |
Kubota T, Durek T, Dang B, Finol-Urdaneta RK, Craik DJ, Kent SB, French RJ, Bezanilla F, Correa AM. Mapping of voltage sensor positions in resting and inactivated mammalian sodium channels by LRET. Proceedings of the National Academy of Sciences of the United States of America. PMID 28202723 DOI: 10.1073/Pnas.1700453114 |
0.577 |
|
| 2017 |
Dang B, Shen R, Kubota T, Mandal K, Bezanilla F, Roux B, Kent SB. Inversion of the Side-Chain Stereochemistry of Indvidual Thr or Ile Residues in a Protein Molecule: Impact on the Folding, Stability, and Structure of the ShK Toxin. Angewandte Chemie (International Ed. in English). PMID 28194851 DOI: 10.1002/Anie.201612398 |
0.644 |
|
| 2017 |
Gates ZP, Baxa MC, Yu W, Riback JA, Li H, Roux B, Kent SB, Sosnick TR. Perplexing cooperative folding and stability of a low-sequence complexity, polyproline 2 protein lacking a hydrophobic core. Proceedings of the National Academy of Sciences of the United States of America. PMID 28193869 DOI: 10.1073/Pnas.1609579114 |
0.748 |
|
| 2016 |
Kent S, Dhayalan B, Mandal K, Rege N, Weiss M, Eitel S, Meier T, Schoenleber R. Scope & Limitations of Fmoc Chemistry SPPS-Based Approaches to the Total Synthesis of Insulin Lispro via Ester Insulin. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 27905149 DOI: 10.1002/Chem.201605578 |
0.395 |
|
| 2016 |
Gates ZP, Dhayalan B, Kent SB. Obviation of hydrogen fluoride in Boc chemistry solid phase peptide synthesis of peptide-(α)thioesters. Chemical Communications (Cambridge, England). PMID 27847960 DOI: 10.1039/C6Cc07891E |
0.757 |
|
| 2016 |
Boerema DJ, Tereshko VA, Zhang J, Kent SB. Chemical synthesis and enzymatic properties of RNase A analogues designed to enhance second-step catalytic activity. Organic & Biomolecular Chemistry. 14: 8804-8814. PMID 27714155 DOI: 10.1039/C6Ob01163B |
0.8 |
|
| 2016 |
Dang B, Kubota T, Mandal K, Correa AM, Bezanilla F, Kent SB. Elucidation of the Covalent and Tertiary Structures of Biologically Active Ts3 Toxin. Angewandte Chemie (International Ed. in English). PMID 27244051 DOI: 10.1002/Anie.201603420 |
0.68 |
|
| 2016 |
Castillo JP, Sánchez-Rodríguez JE, Hyde HC, Zaelzer CA, Aguayo D, Sepúlveda RV, Luk LY, Kent SB, Gonzalez-Nilo FD, Bezanilla F, Latorre R. β1-subunit-induced structural rearrangements of the Ca2+- and voltage-activated K+ (BK) channel. Proceedings of the National Academy of Sciences of the United States of America. PMID 27217576 DOI: 10.1073/Pnas.1606381113 |
0.728 |
|
| 2016 |
Uppalapati M, Lee DJ, Mandal K, Li H, Miranda LP, Lowitz J, Kenney J, Adams JJ, Ault-Riche D, Kent SB, Sidhu SS. A Potent D-protein Antagonist of VEGF-A is Nonimmunogenic, Metabolically Stable and Longer-Circulating In Vivo. Acs Chemical Biology. PMID 26745345 DOI: 10.1021/Acschembio.5B01006 |
0.322 |
|
| 2016 |
Kubota T, Dang B, Carvalho-de-Souza JL, Kent SB, Correa AM, Bezanilla F. High Affinity Nav Channel Binder with Specific Conjugation Site Derived from Scorpion Toxin with Attenuated Toxicity Biophysical Journal. 110: 113a. DOI: 10.1016/J.Bpj.2015.11.664 |
0.599 |
|
| 2015 |
Dhayalan B, Fitzpatrick A, Mandal K, Whittaker J, Weiss M, Tokmakoff A, Kent S. Efficient Total Chemical Synthesis of 13C=18O Isotopomers of Human Insulin for Isotope-Edited FTIR. Chembiochem : a European Journal of Chemical Biology. PMID 26715336 DOI: 10.1002/Cbic.201500601 |
0.383 |
|
| 2015 |
Kent S, Mandal K, Dhayalan B, Avital-Shmilovici M, Tokmakoff A. Crystallization of enantiomerically pure proteins from quasi-racemic mixtures: structure determination by X-ray diffraction of isotope-labeled ester insulin and human insulin. Chembiochem : a European Journal of Chemical Biology. PMID 26707939 DOI: 10.1002/Cbic.201500600 |
0.358 |
|
| 2015 |
Dang B, Dhayalan B, Kent SB. Enhanced Solvation of Peptides Attached to "Solid-Phase" Resins: Straightforward Syntheses of the Elastin Sequence Pro-Gly-Val-Gly-Val-Pro-Gly-Val-Gly-Val. Organic Letters. PMID 26110966 DOI: 10.1021/Acs.Orglett.5B01632 |
0.643 |
|
| 2015 |
Zhang JG, Farley A, Nicholson SE, Willson TA, Zugaro LM, Simpson RJ, Moritz RL, Cary D, Richardson R, Hausmann G, Kile BT, Kent SB, Alexander WS, Metcalf D, Hilton DJ, et al. Correction for Zhang et al., The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation. Proceedings of the National Academy of Sciences of the United States of America. 112: E2979. PMID 25956176 DOI: 10.1073/Pnas.1507812112 |
0.47 |
|
| 2015 |
Bunker RD, Mandal K, Bashiri G, Chaston JJ, Pentelute BL, Lott JS, Kent SB, Baker EN. A functional role of Rv1738 in Mycobacterium tuberculosis persistence suggested by racemic protein crystallography. Proceedings of the National Academy of Sciences of the United States of America. 112: 4310-5. PMID 25831534 DOI: 10.1073/Pnas.1422387112 |
0.629 |
|
| 2015 |
Carvalho-de-Souza JL, Treger JS, Dang B, Kent SB, Pepperberg DR, Bezanilla F. Photosensitivity of neurons enabled by cell-targeted gold nanoparticles. Neuron. 86: 207-17. PMID 25772189 DOI: 10.1016/J.Neuron.2015.02.033 |
0.558 |
|
| 2015 |
Kent SB. The critical role of peptide chemistry in the life sciences. Journal of Peptide Science : An Official Publication of the European Peptide Society. 21: 136-8. PMID 25643657 DOI: 10.1002/Psc.2754 |
0.415 |
|
| 2015 |
Carvalho-de-Souza JL, Treger JS, Dang B, Kent S, Pepperberg DR, Bezanilla F. Robust Optical Stimulation of Neuronal Activity using Functionalized Gold Nanoparticles Biophysical Journal. 108: 207a. DOI: 10.1016/J.Bpj.2014.11.1144 |
0.56 |
|
| 2014 |
Kent SB, Alewood PF. Editorial overview: synthetic biomolecules. Current Opinion in Chemical Biology. 22: viii-xi. PMID 25438804 DOI: 10.1016/J.Cbpa.2014.09.037 |
0.303 |
|
| 2014 |
Avital-Shmilovici M, Whittaker J, Weiss MA, Kent SB. Deciphering a molecular mechanism of neonatal diabetes mellitus by the chemical synthesis of a protein diastereomer, [D-AlaB8]human proinsulin. The Journal of Biological Chemistry. 289: 23683-92. PMID 25002580 DOI: 10.1074/Jbc.M114.572040 |
0.332 |
|
| 2014 |
Dang B, Kubota T, Correa AM, Bezanilla F, Kent SB. Total chemical synthesis of biologically active fluorescent dye-labeled Ts1 toxin. Angewandte Chemie (International Ed. in English). 53: 8970-4. PMID 24989851 DOI: 10.1002/Anie.201404438 |
0.637 |
|
| 2014 |
Okamoto R, Mandal K, Sawaya MR, Kajihara Y, Yeates TO, Kent SB. (Quasi-)racemic X-ray structures of glycosylated and non-glycosylated forms of the chemokine Ser-CCL1 prepared by total chemical synthesis. Angewandte Chemie (International Ed. in English). 53: 5194-8. PMID 24692304 DOI: 10.1002/Anie.201400679 |
0.398 |
|
| 2014 |
Deng FK, Zhang L, Wang YT, Schneewind O, Kent SB. Total chemical synthesis of the enzyme sortase A(ΔN59) with full catalytic activity. Angewandte Chemie (International Ed. in English). 53: 4662-6. PMID 24668498 DOI: 10.1002/Anie.201310900 |
0.597 |
|
| 2014 |
Okamoto R, Mandal K, Ling M, Luster AD, Kajihara Y, Kent SB. Total chemical synthesis and biological activities of glycosylated and non-glycosylated forms of the chemokines CCL1 and Ser-CCL1. Angewandte Chemie (International Ed. in English). 53: 5188-93. PMID 24644239 DOI: 10.1002/Anie.201310574 |
0.426 |
|
| 2014 |
Kubota T, Brugarolas P, Dang B, Finol-Urdaneta RK, Frezza L, French RJ, Kent SB, Bezanilla F, Correa AM. Tracking Voltage-Dependent Conformational Changes of the VSD in Nav with LRET Biophysical Journal. 106: 133a. DOI: 10.1016/J.Bpj.2013.11.781 |
0.611 |
|
| 2014 |
Kubota T, Dang B, Finol-Urdaneta RK, Lacroix JJ, Frezza L, French RJ, Kent SB, Correa AM, Bezanilla F. Searching for the Interaction Sites of the Beta1 Subunit with the Voltage-Sensing Domains of Sodium Channels Using LRET Biophysical Journal. 106: 133a. DOI: 10.1016/J.Bpj.2013.11.780 |
0.578 |
|
| 2013 |
Kent SB. Bringing the science of proteins into the realm of organic chemistry: total chemical synthesis of SEP (synthetic erythropoiesis protein). Angewandte Chemie (International Ed. in English). 52: 11988-96. PMID 24127351 DOI: 10.1002/Anie.201304116 |
0.384 |
|
| 2013 |
Dang B, Kubota T, Mandal K, Bezanilla F, Kent SB. Native chemical ligation at Asx-Cys, Glx-Cys: chemical synthesis and high-resolution X-ray structure of ShK toxin by racemic protein crystallography. Journal of the American Chemical Society. 135: 11911-9. PMID 23919482 DOI: 10.1021/Ja4046795 |
0.7 |
|
| 2013 |
Gordon WR, Bang D, Hoff WD, Kent SB. Total chemical synthesis of fully functional Photoactive Yellow Protein. Bioorganic & Medicinal Chemistry. 21: 3436-42. PMID 23602622 DOI: 10.1016/J.Bmc.2013.03.025 |
0.65 |
|
| 2013 |
Avital-Shmilovici M, Mandal K, Gates ZP, Phillips NB, Weiss MA, Kent SB. Fully convergent chemical synthesis of ester insulin: determination of the high resolution X-ray structure by racemic protein crystallography. Journal of the American Chemical Society. 135: 3173-85. PMID 23343390 DOI: 10.1021/Ja311408Y |
0.73 |
|
| 2013 |
Gates ZP, Stephan JR, Lee DJ, Kent SB. Rapid formal hydrolysis of peptide-αthioesters. Chemical Communications (Cambridge, England). 49: 786-8. PMID 23233036 DOI: 10.1039/C2Cc38229F |
0.752 |
|
| 2012 |
Mandal K, Uppalapati M, Ault-Riché D, Kenney J, Lowitz J, Sidhu SS, Kent SB. Chemical synthesis and X-ray structure of a heterochiral {D-protein antagonist plus vascular endothelial growth factor} protein complex by racemic crystallography. Proceedings of the National Academy of Sciences of the United States of America. 109: 14779-84. PMID 22927390 DOI: 10.1073/Pnas.1210483109 |
0.381 |
|
| 2012 |
Kent S, Sohma Y, Liu S, Bang D, Pentelute B, Mandal K. Through the looking glass--a new world of proteins enabled by chemical synthesis. Journal of Peptide Science : An Official Publication of the European Peptide Society. 18: 428-36. PMID 22674813 DOI: 10.1002/Psc.2421 |
0.774 |
|
| 2012 |
Torbeev VY, Kent SB. Ionization state of the catalytic dyad Asp25/25' in the HIV-1 protease: NMR studies of site-specifically 13C labelled HIV-1 protease prepared by total chemical synthesis. Organic & Biomolecular Chemistry. 10: 5887-91. PMID 22659831 DOI: 10.1039/C2Ob25569C |
0.716 |
|
| 2012 |
Yeates TO, Kent SB. Racemic protein crystallography. Annual Review of Biophysics. 41: 41-61. PMID 22443988 DOI: 10.1146/Annurev-Biophys-050511-102333 |
0.422 |
|
| 2012 |
Mandal K, Pentelute BL, Bang D, Gates ZP, Torbeev VY, Kent SB. Design, total chemical synthesis, and X-ray structure of a protein having a novel linear-loop polypeptide chain topology. Angewandte Chemie (International Ed. in English). 51: 1481-6. PMID 22213444 DOI: 10.1002/Anie.201107846 |
0.79 |
|
| 2012 |
Sawaya MR, Pentelute BL, Kent SB, Yeates TO. Single-wavelength phasing strategy for quasi-racemic protein crystal diffraction data. Acta Crystallographica. Section D, Biological Crystallography. 68: 62-8. PMID 22194334 DOI: 10.1107/S0907444911049985 |
0.612 |
|
| 2012 |
Liu S, Pentelute BL, Kent SB. Convergent chemical synthesis of [lysine(24,38,83)] human erythropoietin. Angewandte Chemie (International Ed. in English). 51: 993-9. PMID 22180156 DOI: 10.1002/Anie.201106060 |
0.619 |
|
| 2011 |
Torbeev VY, Raghuraman H, Hamelberg D, Tonelli M, Westler WM, Perozo E, Kent SB. Protein conformational dynamics in the mechanism of HIV-1 protease catalysis. Proceedings of the National Academy of Sciences of the United States of America. 108: 20982-7. PMID 22158985 DOI: 10.1073/Pnas.1111202108 |
0.738 |
|
| 2011 |
de Araujo AD, Christensen C, Buchardt J, Kent SB, Alewood PF. Synthesis of tripeptide mimetics based on dihydroquinolinone and benzoxazinone scaffolds. Chemistry (Weinheim An Der Bergstrasse, Germany). 17: 13983-6. PMID 22084036 DOI: 10.1002/Chem.201102732 |
0.387 |
|
| 2011 |
Mandal K, Kent SB. Total chemical synthesis of biologically active vascular endothelial growth factor. Angewandte Chemie (International Ed. in English). 50: 8029-33. PMID 21744452 DOI: 10.1002/Anie.201103237 |
0.383 |
|
| 2011 |
Pollock SB, Kent SB. An investigation into the origin of the dramatically reduced reactivity of peptide-prolyl-thioesters in native chemical ligation. Chemical Communications (Cambridge, England). 47: 2342-4. PMID 21173985 DOI: 10.1039/C0Cc04120C |
0.378 |
|
| 2010 |
Pentelute BL, Mandal K, Gates ZP, Sawaya MR, Yeates TO, Kent SB. Total chemical synthesis and X-ray structure of kaliotoxin by racemic protein crystallography. Chemical Communications (Cambridge, England). 46: 8174-6. PMID 20877851 DOI: 10.1039/C0Cc03148H |
0.818 |
|
| 2010 |
Luisier S, Avital-Shmilovici M, Weiss MA, Kent SB. Total chemical synthesis of human proinsulin. Chemical Communications (Cambridge, England). 46: 8177-9. PMID 20877850 DOI: 10.1039/C0Cc03141K |
0.351 |
|
| 2010 |
Alewood P, Engelhard M, Kent SB. Chemical protein synthesis. Journal of Peptide Science : An Official Publication of the European Peptide Society. 16: 513. PMID 20862718 DOI: 10.1002/Psc.1291 |
0.424 |
|
| 2010 |
Deng FK, Mandal K, Luisier S, Kent SB. Synthesis and comparative properties of two amide-generating resin linkers for use in solid phase peptide synthesis. Journal of Peptide Science : An Official Publication of the European Peptide Society. 16: 545-50. PMID 20824627 DOI: 10.1002/Psc.1279 |
0.583 |
|
| 2010 |
Banigan JR, Mandal K, Sawaya MR, Thammavongsa V, Hendrickx AP, Schneewind O, Yeates TO, Kent SB. Determination of the X-ray structure of the snake venom protein omwaprin by total chemical synthesis and racemic protein crystallography. Protein Science : a Publication of the Protein Society. 19: 1840-9. PMID 20669184 DOI: 10.1002/Pro.468 |
0.422 |
|
| 2010 |
Kent S. Origin of the chemical ligation concept for the total synthesis of enzymes (proteins) Biopolymers. 94: iv-ix. PMID 20593463 DOI: 10.1002/Bip.21492 |
0.404 |
|
| 2010 |
Sohma Y, Hua QX, Whittaker J, Weiss MA, Kent SB. Design and folding of [GluA4(ObetaThrB30)]insulin ("ester insulin"): a minimal proinsulin surrogate that can be chemically converted into human insulin. Angewandte Chemie (International Ed. in English). 49: 5489-93. PMID 20509131 DOI: 10.1002/Anie.201001151 |
0.32 |
|
| 2010 |
Pentelute BL, Barker AP, Janowiak BE, Kent SB, Collier RJ. A semisynthesis platform for investigating structure-function relationships in the N-terminal domain of the anthrax Lethal Factor. Acs Chemical Biology. 5: 359-64. PMID 20180595 DOI: 10.1021/Cb100003R |
0.604 |
|
| 2009 |
Lee DJ, Mandal K, Harris PW, Brimble MA, Kent SB. A one-pot approach to neoglycopeptides using orthogonal native chemical ligation and click chemistry. Organic Letters. 11: 5270-3. PMID 19842689 DOI: 10.1021/Ol902131N |
0.411 |
|
| 2009 |
Sohma Y, Kent SB. Biomimetic synthesis of lispro insulin via a chemically synthesized "mini-proinsulin" prepared by oxime-forming ligation. Journal of the American Chemical Society. 131: 16313-8. PMID 19835355 DOI: 10.1021/Ja9052398 |
0.33 |
|
| 2009 |
Bang D, Tereshko V, Kossiakoff AA, Kent SB. Role of a salt bridge in the model protein crambin explored by chemical protein synthesis: X-ray structure of a unique protein analogue, [V15A]crambin-alpha-carboxamide. Molecular Biosystems. 5: 750-6. PMID 19562114 DOI: 10.1039/B903610E |
0.631 |
|
| 2009 |
Mandal K, Pentelute BL, Tereshko V, Thammavongsa V, Schneewind O, Kossiakoff AA, Kent SB. Racemic crystallography of synthetic protein enantiomers used to determine the X-ray structure of plectasin by direct methods. Protein Science : a Publication of the Protein Society. 18: 1146-54. PMID 19472324 DOI: 10.1002/Pro.127 |
0.665 |
|
| 2009 |
Kent SB. Total chemical synthesis of proteins. Chemical Society Reviews. 38: 338-51. PMID 19169452 DOI: 10.1039/B700141J |
0.504 |
|
| 2009 |
Mandal K, Pentelute BL, Tereshko V, Kossiakoff AA, Kent SB. X-ray structure of native scorpion toxin BmBKTx1 by racemic protein crystallography using direct methods. Journal of the American Chemical Society. 131: 1362-3. PMID 19133782 DOI: 10.1021/Ja8077973 |
0.664 |
|
| 2009 |
Torbeev VY, Raghuraman H, Mandal K, Senapati S, Perozo E, Kent SB. Dynamics of "flap" structures in three HIV-1 protease/inhibitor complexes probed by total chemical synthesis and pulse-EPR spectroscopy. Journal of the American Chemical Society. 131: 884-5. PMID 19117390 DOI: 10.1021/Ja806526Z |
0.703 |
|
| 2008 |
Torbeev VY, Mandal K, Terechko VA, Kent SB. Reprint of "Crystal structure of chemically synthesized HIV-1 protease and a ketomethylene isostere inhibitor based on the p2/NC cleavage site" [Bioorg. Med. Chem. Lett. 18 (2008) 4554-4557]. Bioorganic & Medicinal Chemistry Letters. 18: 6012-5. PMID 18995173 DOI: 10.1016/S0960-894X(08)01314-0 |
0.712 |
|
| 2008 |
Torbeev VY, Mandal K, Terechko VA, Kent SB. Crystal structure of chemically synthesized HIV-1 protease and a ketomethylene isostere inhibitor based on the p2/NC cleavage site. Bioorganic & Medicinal Chemistry Letters. 18: 4554-7. PMID 18657969 DOI: 10.1016/J.Bmcl.2008.07.039 |
0.712 |
|
| 2008 |
Pentelute BL, Gates ZP, Tereshko V, Dashnau JL, Vanderkooi JM, Kossiakoff AA, Kent SB. X-ray structure of snow flea antifreeze protein determined by racemic crystallization of synthetic protein enantiomers. Journal of the American Chemical Society. 130: 9695-701. PMID 18598029 DOI: 10.1021/Ja8013538 |
0.809 |
|
| 2008 |
Pentelute BL, Gates ZP, Dashnau JL, Vanderkooi JM, Kent SB. Mirror image forms of snow flea antifreeze protein prepared by total chemical synthesis have identical antifreeze activities. Journal of the American Chemical Society. 130: 9702-7. PMID 18598026 DOI: 10.1021/Ja801352J |
0.824 |
|
| 2008 |
Sohma Y, Pentelute BL, Whittaker J, Hua QX, Whittaker LJ, Weiss MA, Kent SB. Comparative properties of insulin-like growth factor 1 (IGF-1) and [Gly7D-Ala]IGF-1 prepared by total chemical synthesis. Angewandte Chemie (International Ed. in English). 47: 1102-6. PMID 18161716 DOI: 10.1002/Anie.200703521 |
0.575 |
|
| 2008 |
Boerema DJ, Tereshko VA, Kent SB. Total synthesis by modern chemical ligation methods and high resolution (1.1 A) X-ray structure of ribonuclease A. Biopolymers. 90: 278-86. PMID 17610259 DOI: 10.1002/Bip.20800 |
0.798 |
|
| 2007 |
Johnson EC, Kent SB. Towards the total chemical synthesis of integral membrane proteins: a general method for the synthesis of hydrophobic peptide-thioester building blocks. Tetrahedron Letters. 48: 1795-1799. PMID 19177172 DOI: 10.1016/J.Tetlet.2007.01.030 |
0.674 |
|
| 2007 |
Durek T, Zhang J, He C, Kent SB. Synthesis of photoactive analogues of a cystine knot trypsin inhibitor protein. Organic Letters. 9: 5497-500. PMID 18041846 DOI: 10.1021/Ol702461Z |
0.666 |
|
| 2007 |
Johnson EC, Malito E, Shen Y, Pentelute B, Rich D, Florián J, Tang WJ, Kent SB. Insights from atomic-resolution X-ray structures of chemically synthesized HIV-1 protease in complex with inhibitors. Journal of Molecular Biology. 373: 573-86. PMID 17869270 DOI: 10.1016/J.Jmb.2007.07.054 |
0.738 |
|
| 2007 |
Johnson EC, Malito E, Shen Y, Rich D, Tang WJ, Kent SB. Modular total chemical synthesis of a human immunodeficiency virus type 1 protease. Journal of the American Chemical Society. 129: 11480-90. PMID 17705484 DOI: 10.1021/Ja072870N |
0.697 |
|
| 2007 |
Rajagopal S, Kent SB. Total chemical synthesis and biophysical characterization of the minimal isoform of the KChIP2 potassium channel regulatory subunit. Protein Science : a Publication of the Protein Society. 16: 2056-64. PMID 17660260 DOI: 10.1110/Ps.072876107 |
0.397 |
|
| 2007 |
Torbeev VY, Kent SB. Convergent chemical synthesis and crystal structure of a 203 amino acid "covalent dimer" HIV-1 protease enzyme molecule. Angewandte Chemie (International Ed. in English). 46: 1667-70. PMID 17397076 DOI: 10.1002/Anie.200604087 |
0.727 |
|
| 2007 |
Durek T, Torbeev VY, Kent SB. Convergent chemical synthesis and high-resolution x-ray structure of human lysozyme. Proceedings of the National Academy of Sciences of the United States of America. 104: 4846-51. PMID 17360367 DOI: 10.1073/Pnas.0610630104 |
0.769 |
|
| 2007 |
Pentelute BL, Kent SB. Selective desulfurization of cysteine in the presence of Cys(Acm) in polypeptides obtained by native chemical ligation. Organic Letters. 9: 687-90. PMID 17286375 DOI: 10.1021/Ol0630144 |
0.695 |
|
| 2007 |
Johnson EC, Kent SB. Exploratory synthesis of peptide-alpha-thioester segments spanning the polypeptide sequence of the delta-opioid receptor, a G protein-coupled receptor. Biopolymers. 88: 340-9. PMID 17120238 DOI: 10.1002/Bip.20639 |
0.665 |
|
| 2006 |
Parker LL, Brueggemeier SB, Rhee WJ, Wu D, Kent SB, Kron SJ, Palecek SP. Photocleavable peptide hydrogel arrays for MALDI-TOF analysis of kinase activity. The Analyst. 131: 1097-104. PMID 17003856 DOI: 10.1039/B607180E |
0.734 |
|
| 2006 |
Parker LL, Kurutz JW, Kent SB, Kron SJ. Control of the yeast cell cycle with a photocleavable alpha-factor analogue. Angewandte Chemie (International Ed. in English). 45: 6322-5. PMID 16937420 DOI: 10.1002/Anie.200602439 |
0.716 |
|
| 2006 |
Johnson EC, Kent SB. Studies on the insolubility of a transmembrane peptide from signal peptide peptidase. Journal of the American Chemical Society. 128: 7140-1. PMID 16734449 DOI: 10.1021/Ja058377Y |
0.673 |
|
| 2006 |
Johnson EC, Kent SB. Insights into the mechanism and catalysis of the native chemical ligation reaction. Journal of the American Chemical Society. 128: 6640-6. PMID 16704265 DOI: 10.1021/Ja058344I |
0.671 |
|
| 2006 |
Bang D, Pentelute BL, Kent SB. Kinetically controlled ligation for the convergent chemical synthesis of proteins. Angewandte Chemie (International Ed. in English). 45: 3985-8. PMID 16639756 DOI: 10.1002/Anie.200600702 |
0.729 |
|
| 2006 |
Johnson EC, Durek T, Kent SB. Total chemical synthesis, folding, and assay of a small protein on a water-compatible solid support. Angewandte Chemie (International Ed. in English). 45: 3283-7. PMID 16596681 DOI: 10.1002/Anie.200600381 |
0.647 |
|
| 2006 |
Johnson EC, Kent SB. Synthesis, stability and optimized photolytic cleavage of 4-methoxy-2-nitrobenzyl backbone-protected peptides. Chemical Communications (Cambridge, England). 1557-9. PMID 16575459 DOI: 10.1039/B600304D |
0.651 |
|
| 2006 |
Bang D, Pentelute BL, Gates ZP, Kent SB. Direct on-resin synthesis of peptide-alphathiophenylesters for use in native chemical ligation. Organic Letters. 8: 1049-52. PMID 16524265 DOI: 10.1021/Ol052811J |
0.789 |
|
| 2006 |
Bang D, Gribenko AV, Tereshko V, Kossiakoff AA, Kent SB, Makhatadze GI. Dissecting the energetics of protein alpha-helix C-cap termination through chemical protein synthesis. Nature Chemical Biology. 2: 139-43. PMID 16446709 DOI: 10.1038/Nchembio766 |
0.564 |
|
| 2006 |
Kent S. Chemistry of Peptide Synthesis. Edited by N. Leo Benoiton. Angewandte Chemie. 45: 4234-4234. DOI: 10.1002/Anie.200585369 |
0.362 |
|
| 2006 |
Kent S. Chemistry of Peptide Synthesis. Von N. Leo Benoiton. Angewandte Chemie. 118: 4340-4340. DOI: 10.1002/Ange.200585369 |
0.362 |
|
| 2005 |
Parker LL, Schilling AB, Kron SJ, Kent SB. Optimizing thiophosphorylation in the presence of competing phosphorylation with MALDI-TOF-MS detection. Journal of Proteome Research. 4: 1863-6. PMID 16212443 DOI: 10.1021/Pr050150E |
0.681 |
|
| 2005 |
Bang D, Makhatadze GI, Tereshko V, Kossiakoff AA, Kent SB. Total chemical synthesis and X-ray crystal structure of a protein diastereomer: [D-Gln 35]ubiquitin. Angewandte Chemie (International Ed. in English). 44: 3852-6. PMID 15834850 DOI: 10.1002/Anie.200463040 |
0.582 |
|
| 2005 |
Chen SY, Cressman S, Mao F, Shao H, Low DW, Beilan HS, Cagle EN, Carnevali M, Gueriguian V, Keogh PJ, Porter H, Stratton SM, Wiedeke MC, Savatski L, Adamson JW, ... ... Kent SB, et al. Synthetic erythropoietic proteins: tuning biological performance by site-specific polymer attachment. Chemistry & Biology. 12: 371-83. PMID 15797221 DOI: 10.1016/J.Chembiol.2005.01.017 |
0.33 |
|
| 2005 |
Bang D, Kent SB. His6 tag-assisted chemical protein synthesis. Proceedings of the National Academy of Sciences of the United States of America. 102: 5014-9. PMID 15784744 DOI: 10.1073/Pnas.0407648102 |
0.658 |
|
| 2004 |
Kent S. Novel forms of chemical protein diversity - In nature and in the laboratory Current Opinion in Biotechnology. 15: 607-614. PMID 15560989 DOI: 10.1016/J.Copbio.2004.10.003 |
0.431 |
|
| 2004 |
Hartley O, Gaertner H, Wilken J, Thompson D, Fish R, Ramos A, Pastore C, Dufour B, Cerini F, Melotti A, Heveker N, Picard L, Alizon M, Mosier D, Kent S, et al. Medicinal chemistry applied to a synthetic protein: Development of highly potent HIV entry inhibitors Proceedings of the National Academy of Sciences of the United States of America. 101: 16460-16465. PMID 15545608 DOI: 10.1073/Pnas.0404802101 |
0.675 |
|
| 2004 |
Bang D, Kent SB. A one-pot total synthesis of crambin. Angewandte Chemie (International Ed. in English). 43: 2534-8. PMID 15127445 DOI: 10.1002/Anie.200353540 |
0.546 |
|
| 2004 |
Bang D, Chopra N, Kent SB. Total chemical synthesis of crambin. Journal of the American Chemical Society. 126: 1377-83. PMID 14759195 DOI: 10.1021/Ja0385078 |
0.653 |
|
| 2003 |
Kent S. Total chemical synthesis of enzymes Journal of Peptide Science. 9: 574-593. PMID 14552420 DOI: 10.1002/Psc.475 |
0.381 |
|
| 2003 |
Becker CF, Hunter CL, Seidel R, Kent SB, Goody RS, Engelhard M. Total chemical synthesis of a functional interacting protein pair: the protooncogene H-Ras and the Ras-binding domain of its effector c-Raf1. Proceedings of the National Academy of Sciences of the United States of America. 100: 5075-80. PMID 12704243 DOI: 10.1073/Pnas.0831227100 |
0.35 |
|
| 2003 |
Kochendoerfer GG, Chen SY, Mao F, Cressman S, Traviglia S, Shao H, Hunter CL, Low DW, Cagle EN, Carnevali M, Gueriguian V, Keogh PJ, Porter H, Stratton SM, Wiedeke MC, ... ... Kent SB, et al. Design and chemical synthesis of a homogeneous polymer-modified erythropoiesis protein. Science (New York, N.Y.). 299: 884-7. PMID 12574628 DOI: 10.1126/Science.1079085 |
0.392 |
|
| 2001 |
Low DW, Hill MG, Carrasco MR, Kent SB, Botti P. Total synthesis of cytochrome b562 by native chemical ligation using a removable auxiliary. Proceedings of the National Academy of Sciences of the United States of America. 98: 6554-9. PMID 11390992 DOI: 10.1073/Pnas.121178598 |
0.465 |
|
| 2001 |
Marcaurelle LA, Mizoue LS, Wilken J, Oldham L, Kent SB, Handel TM, Bertozzi CR. Chemical synthesis of lymphotactin: a glycosylated chemokine with a C-terminal mucin-like domain. Chemistry (Weinheim An Der Bergstrasse, Germany). 7: 1129-32. PMID 11303872 DOI: 10.1002/1521-3765(20010302)7:5<1129::Aid-Chem1129>3.0.Co;2-W |
0.381 |
|
| 2000 |
Hackeng TM, Fernández JA, Dawson PE, Kent SB, Griffin JH. Chemical synthesis and spontaneous folding of a multidomain protein: anticoagulant microprotein S. Proceedings of the National Academy of Sciences of the United States of America. 97: 14074-8. PMID 11106381 DOI: 10.1073/Pnas.260239797 |
0.604 |
|
| 2000 |
Dawson PE, Kent SB. Synthesis of native proteins by chemical ligation. Annual Review of Biochemistry. 69: 923-60. PMID 10966479 DOI: 10.1146/Annurev.Biochem.69.1.923 |
0.651 |
|
| 2000 |
Kent S, Marshall GR, Wlodawer A. Determining the 3D structure of HIV-1 protease. Science (New York, N.Y.). 288: 1590. PMID 10858137 DOI: 10.1126/Science.288.5471.1590A |
0.469 |
|
| 2000 |
Lu WY, Starovasnik MA, Dwyer JJ, Kossiakoff AA, Kent SB, Lu W. Deciphering the role of the electrostatic interactions involving Gly70 in eglin C by total chemical protein synthesis. Biochemistry. 39: 3575-84. PMID 10736156 DOI: 10.1021/Bi992292Q |
0.381 |
|
| 1999 |
Panzer U, Schneider A, Wilken J, Thompson DA, Kent SB, Stahl RA. The chemokine receptor antagonist AOP-RANTES reduces monocyte infiltration in experimental glomerulonephritis. Kidney International. 56: 2107-15. PMID 10594786 DOI: 10.1046/J.1523-1755.1999.00767.X |
0.603 |
|
| 1999 |
Bark SJ, Kent SB. Engineering an unnatural Nalpha-anchored disulfide into BPTI by total chemical synthesis: structural and functional consequences. Febs Letters. 460: 67-76. PMID 10571063 DOI: 10.1016/S0014-5793(99)01310-1 |
0.391 |
|
| 1999 |
Kochendoerfer GG, Salom D, Lear JD, Wilk-Orescan R, Kent SB, DeGrado WF. Total chemical synthesis of the integral membrane protein influenza A virus M2: role of its C-terminal domain in tetramer assembly. Biochemistry. 38: 11905-13. PMID 10508393 DOI: 10.1021/Bi990720M |
0.432 |
|
| 1999 |
Sydor JR, Herrmann C, Kent SB, Goody RS, Engelhard M. Design, total chemical synthesis, and binding properties of a [Leu-91-N1-methyl-7-azaTrp]Ras-binding domain of c-Raf-1. Proceedings of the National Academy of Sciences of the United States of America. 96: 7865-70. PMID 10393913 DOI: 10.1073/Pnas.96.14.7865 |
0.393 |
|
| 1999 |
Lu W, Randal M, Kossiakoff A, Kent SB. Probing intermolecular backbone H-bonding in serine proteinase-protein inhibitor complexes. Chemistry & Biology. 6: 419-27. PMID 10381402 DOI: 10.1016/S1074-5521(99)80060-X |
0.329 |
|
| 1999 |
Bolin KA, Anderson DJ, Trulson JA, Thompson DA, Wilken J, Kent SB, Gantz I, Millhauser GL. NMR structure of a minimized human agouti related protein prepared by total chemical synthesis. Febs Letters. 451: 125-31. PMID 10371151 DOI: 10.1016/S0014-5793(99)00553-0 |
0.717 |
|
| 1999 |
Zhang JG, Farley A, Nicholson SE, Willson TA, Zugaro LM, Simpson RJ, Moritz RL, Cary D, Richardson R, Hausmann G, Kile BJ, Kent SB, Alexander WS, Metcalf D, Hilton DJ, et al. The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation. Proceedings of the National Academy of Sciences of the United States of America. 96: 2071-6. PMID 10051596 DOI: 10.1073/Pnas.96.5.2071 |
0.519 |
|
| 1999 |
Yang YK, Thompson DA, Dickinson CJ, Wilken J, Barsh GS, Kent SB, Gantz I. Characterization of Agouti-related protein binding to melanocortin receptors. Molecular Endocrinology (Baltimore, Md.). 13: 148-55. PMID 9892020 DOI: 10.1210/Mend.13.1.0223 |
0.667 |
|
| 1999 |
Wilken J, Hoover D, Thompson DA, Barlow PN, McSparron H, Picard L, Wlodawer A, Lubkowski J, Kent SB. Total chemical synthesis and high-resolution crystal structure of the potent anti-HIV protein AOP-RANTES. Chemistry & Biology. 6: 43-51. PMID 9889151 DOI: 10.1016/S1074-5521(99)80019-2 |
0.712 |
|
| 1998 |
Wilken J, Kent SB. Chemical protein synthesis. Current Opinion in Biotechnology. 9: 412-26. PMID 9720266 |
0.344 |
|
| 1998 |
Hackeng TM, Dawson PE, Kent SB, Griffin JH. Chemical synthesis of human protein S thrombin-sensitive module and first epidermal growth factor module. Biopolymers. 46: 53-63. PMID 9664841 DOI: 10.1002/(Sici)1097-0282(199808)46:2<53::Aid-Bip1>3.0.Co;2-W |
0.613 |
|
| 1998 |
Lu W, Starovasnik MA, Kent SB. Total chemical synthesis of bovine pancreatic trypsin inhibitor by native chemical ligation. Febs Letters. 429: 31-5. PMID 9657378 DOI: 10.1016/S0014-5793(98)00547-X |
0.462 |
|
| 1998 |
Miller M, Baca M, Mohana Rao J, Kent SB. Probing the structural basis of the catalytic activity of HIV-1 PR through total chemical protein synthesis Journal of Molecular Structure: Theochem. 423: 137-152. DOI: 10.1016/S0166-1280(96)05022-1 |
0.409 |
|
| 1998 |
Shao Y, Lu W, Kent SB. A novel method to synthesize cyclic peptides Tetrahedron Letters. 39: 3911-3914. DOI: 10.1016/S0040-4039(98)00725-4 |
0.41 |
|
| 1997 |
Fitzgerald MC, Laco GS, Elder JH, Kent SB. A continuous fluorometric assay for the feline immunodeficiency virus protease. Analytical Biochemistry. 254: 226-30. PMID 9417781 DOI: 10.1006/Abio.1997.2407 |
0.493 |
|
| 1997 |
Muir TW, Dawson PE, Fitzgerald MC, Kent SB. Protein signature analysis: a practical new approach for studying structure-activity relationships in peptides and proteins. Methods in Enzymology. 289: 545-64. PMID 9353737 DOI: 10.1016/S0076-6879(97)89063-5 |
0.771 |
|
| 1997 |
Muir TW, Dawson PE, Kent SB. Protein synthesis by chemical ligation of unprotected peptides in aqueous solution. Methods in Enzymology. 289: 266-98. PMID 9353726 DOI: 10.1016/S0076-6879(97)89052-0 |
0.716 |
|
| 1997 |
Hackeng TM, Mounier CM, Bon C, Dawson PE, Griffin JH, Kent SB. Total chemical synthesis of enzymatically active human type II secretory phospholipase A2. Proceedings of the National Academy of Sciences of the United States of America. 94: 7845-50. PMID 9223275 DOI: 10.1073/Pnas.94.15.7845 |
0.622 |
|
| 1997 |
Laco GS, Fitzgerald MC, Morris GM, Olson AJ, Kent SB, Elder JH. Molecular analysis of the feline immunodeficiency virus protease: generation of a novel form of the protease by autoproteolysis and construction of cleavage-resistant proteases. Journal of Virology. 71: 5505-11. PMID 9188624 DOI: 10.1128/Jvi.71.7.5505-5511.1997 |
0.539 |
|
| 1997 |
Shao Y, Kent SB. Protein splicing: occurrence, mechanisms and related phenomena. Chemistry & Biology. 4: 187-94. PMID 9115411 DOI: 10.1016/S1074-5521(97)90287-8 |
0.352 |
|
| 1997 |
Miller M, Geller M, Gribskov M, Kent SB. Analysis of the structure of chemically synthesized HIV-1 protease complexed with a hexapeptide inhibitor. Part I: Crystallographic refinement of 2 A data. Proteins. 27: 184-94. PMID 9061782 DOI: 10.1002/(Sici)1097-0134(199702)27:2<184::Aid-Prot4>3.0.Co;2-G |
0.345 |
|
| 1997 |
Zhao Y, Kent SB, Chait BT. Rapid, sensitive structure analysis of oligosaccharides. Proceedings of the National Academy of Sciences of the United States of America. 94: 1629-33. PMID 9050829 DOI: 10.1073/Pnas.94.5.1629 |
0.379 |
|
| 1997 |
Lu W, Qasim MA, Laskowski M, Kent SB. Probing intermolecular main chain hydrogen bonding in serine proteinase-protein inhibitor complexes: chemical synthesis of backbone-engineered turkey ovomucoid third domain. Biochemistry. 36: 673-9. PMID 9020764 DOI: 10.1021/Bi9625612 |
0.365 |
|
| 1996 |
Muir TW, Dawson PE, Fitzgerald MC, Kent SB. Probing the chemical basis of binding activity in an SH3 domain by protein signature analysis. Chemistry & Biology. 3: 817-25. PMID 8939700 DOI: 10.1016/S1074-5521(96)90067-8 |
0.768 |
|
| 1996 |
Smith R, Brereton IM, Chai RY, Kent SB. Ionization states of the catalytic residues in HIV-1 protease. Nature Structural Biology. 3: 946-50. PMID 8901873 DOI: 10.1038/Nsb1196-946 |
0.344 |
|
| 1996 |
Schnölzer M, Rackwitz HR, Gustchina A, Laco GS, Wlodawer A, Elder JH, Kent SB. Comparative properties of feline immunodeficiency virus (FIV) and human immunodeficiency virus type 1 (HIV-1) proteinases prepared by total chemical synthesis. Virology. 224: 268-75. PMID 8862421 DOI: 10.1006/Viro.1996.0528 |
0.394 |
|
| 1996 |
Bruick RK, Dawson PE, Kent SB, Usman N, Joyce GF. Template-directed ligation of peptides to oligonucleotides. Chemistry & Biology. 3: 49-56. PMID 8807828 DOI: 10.1016/S1074-5521(96)90084-8 |
0.596 |
|
| 1996 |
Fitzgerald MC, Chernushevich I, Standing KG, Whitman CP, Kent SB. Probing the oligomeric structure of an enzyme by electrospray ionization time-of-flight mass spectrometry. Proceedings of the National Academy of Sciences of the United States of America. 93: 6851-6. PMID 8692908 DOI: 10.1073/Pnas.93.14.6851 |
0.541 |
|
| 1996 |
Zhao Y, Muir TW, Kent SB, Tischer E, Scardina JM, Chait BT. Mapping protein-protein interactions by affinity-directed mass spectrometry. Proceedings of the National Academy of Sciences of the United States of America. 93: 4020-4. PMID 8633009 DOI: 10.1073/Pnas.93.9.4020 |
0.562 |
|
| 1995 |
Kent SB, Baca M, Elder J, Miller M, Milton R, Milton S, Rao JK, Schnölzer M. Breaking the shackles of the genetic code: engineering retroviral proteases through total chemical synthesis. Advances in Experimental Medicine and Biology. 362: 425-38. PMID 8540353 DOI: 10.1007/978-1-4615-1871-6_55 |
0.382 |
|
| 1995 |
Muir TW, Williams MJ, Kent SB. Detection of synthetic protein isomers and conformers by electrospray mass spectrometry. Analytical Biochemistry. 224: 100-9. PMID 7710055 DOI: 10.1006/Abio.1995.1013 |
0.507 |
|
| 1995 |
Canne LE, Walker SM, Kent SB. A general method for the synthesis of thioester resin linkers for use in the solid phase synthesis of peptide-α-thioacids Tetrahedron Letters. 36: 1217-1220. DOI: 10.1016/0040-4039(95)00037-D |
0.387 |
|
| 1994 |
Nielsen KJ, Alewood D, Andrews J, Kent SB, Craik DJ. An 1H NMR determination of the three-dimensional structures of mirror-image forms of a Leu-5 variant of the trypsin inhibitor from Ecballium elaterium (EETI-II). Protein Science : a Publication of the Protein Society. 3: 291-302. PMID 8003965 DOI: 10.1002/Pro.5560030213 |
0.352 |
|
| 1994 |
Dawson PE, Muir TW, Clark-Lewis I, Kent SB. Synthesis of proteins by native chemical ligation. Science (New York, N.Y.). 266: 776-9. PMID 7973629 |
0.717 |
|
| 1994 |
Muir TW, Williams MJ, Ginsberg MH, Kent SB. Design and chemical synthesis of a neoprotein structural model for the cytoplasmic domain of a multisubunit cell-surface receptor: integrin alpha IIb beta 3 (platelet GPIIb-IIIa). Biochemistry. 33: 7701-8. PMID 7516703 DOI: 10.1021/Bi00190A025 |
0.566 |
|
| 1993 |
Elder JH, Schnölzer M, Hasselkus-Light CS, Henson M, Lerner DA, Phillips TR, Wagaman PC, Kent SB. Identification of proteolytic processing sites within the Gag and Pol polyproteins of feline immunodeficiency virus. Journal of Virology. 67: 1869-76. PMID 8383214 DOI: 10.1128/Jvi.67.4.1869-1876.1993 |
0.366 |
|
| 1993 |
Baca M, Alewood PF, Kent SB. Structural engineering of the HIV-1 protease molecule with a beta-turn mimic of fixed geometry. Protein Science : a Publication of the Protein Society. 2: 1085-91. PMID 8358291 DOI: 10.1002/Pro.5560020702 |
0.355 |
|
| 1993 |
Baca M, Kent SB. Catalytic contribution of flap-substrate hydrogen bonds in "HIV-1 protease" explored by chemical synthesis. Proceedings of the National Academy of Sciences of the United States of America. 90: 11638-42. PMID 8265601 DOI: 10.1073/Pnas.90.24.11638 |
0.343 |
|
| 1993 |
Chait BT, Wang R, Beavis RC, Kent SB. Protein ladder sequencing. Science (New York, N.Y.). 262: 89-92. PMID 8211132 DOI: 10.1126/Science.8211132 |
0.375 |
|
| 1993 |
Muir TW, Kent SB. The chemical synthesis of proteins. Current Opinion in Biotechnology. 4: 420-7. PMID 7763972 DOI: 10.1016/0958-1669(93)90007-J |
0.617 |
|
| 1992 |
Milton RC, Milton SC, Kent SB. Total chemical synthesis of a D-enzyme: the enantiomers of HIV-1 protease show reciprocal chiral substrate specificity [corrected]. Science (New York, N.Y.). 256: 1445-8. PMID 1604320 DOI: 10.1126/Science.1604320 |
0.416 |
|
| 1992 |
Schnölzer M, Kent SB. Constructing proteins by dovetailing unprotected synthetic peptides: backbone-engineered HIV protease. Science (New York, N.Y.). 256: 221-5. PMID 1566069 DOI: 10.1126/Science.1566069 |
0.439 |
|
| 1992 |
Schnölzer M, Alewood P, Jones A, Alewood D, Kent SB. In situ neutralization in Boc-chemistry solid phase peptide synthesis. Rapid, high yield assembly of difficult sequences. International Journal of Peptide and Protein Research. 40: 180-93. PMID 1478777 DOI: 10.1111/J.1399-3011.1992.Tb00291.X |
0.388 |
|
| 1992 |
Schnölzer M, Jones A, Alewood PF, Kent SB. Ion-spray tandem mass spectrometry in peptide synthesis: structural characterization of minor by-products in the synthesis of ACP(65-74). Analytical Biochemistry. 204: 335-43. PMID 1443533 DOI: 10.1016/0003-2697(92)90249-7 |
0.378 |
|
| 1992 |
Chait BT, Kent SB. Weighing naked proteins: practical, high-accuracy mass measurement of peptides and proteins. Science (New York, N.Y.). 257: 1885-94. PMID 1411504 DOI: 10.1126/Science.1411504 |
0.369 |
|
| 1992 |
Alewood PF, Brinkworth RI, Dancer RJ, Garnham B, Jones A, Kent SB. Solid phase synthesis of hydroxyethylamine peptide bond isosteres: Synthesis of the potent HIV-1 protease inhibitor JG365 Tetrahedron Letters. 33: 977-980. DOI: 10.1016/S0040-4039(00)91592-2 |
0.381 |
|
| 1991 |
Jaskólski M, Tomasselli AG, Sawyer TK, Staples DG, Heinrikson RL, Schneider J, Kent SB, Wlodawer A. Structure at 2.5-A resolution of chemically synthesized human immunodeficiency virus type 1 protease complexed with a hydroxyethylene-based inhibitor. Biochemistry. 30: 1600-9. PMID 1993177 DOI: 10.1021/Bi00220A023 |
0.36 |
|
| 1990 |
Swain AL, Miller MM, Green J, Rich DH, Schneider J, Kent SB, Wlodawer A. X-ray crystallographic structure of a complex between a synthetic protease of human immunodeficiency virus 1 and a substrate-based hydroxyethylamine inhibitor. Proceedings of the National Academy of Sciences of the United States of America. 87: 8805-9. PMID 2247451 DOI: 10.1073/Pnas.87.22.8805 |
0.358 |
|
| 1990 |
Rich DH, Green J, Toth MV, Marshall GR, Kent SB. Hydroxyethylamine analogues of the p17/p24 substrate cleavage site are tight-binding inhibitors of HIV protease. Journal of Medicinal Chemistry. 33: 1285-8. PMID 2184237 DOI: 10.1021/Jm00167A003 |
0.454 |
|
| 1989 |
Woo DD, Clark-Lewis I, Chait BT, Kent SB. Chemical synthesis in protein engineering: total synthesis, purification and covalent structural characterization of a mitogenic protein, human transforming growth factor-alpha. Protein Engineering. 3: 29-37. PMID 2813340 DOI: 10.1093/Protein/3.1.29 |
0.391 |
|
| 1989 |
Miller M, Schneider J, Sathyanarayana BK, Toth MV, Marshall GR, Clawson L, Selk L, Kent SB, Wlodawer A. Structure of complex of synthetic HIV-1 protease with a substrate-based inhibitor at 2.3 A resolution. Science (New York, N.Y.). 246: 1149-52. PMID 2686029 DOI: 10.1126/Science.2686029 |
0.592 |
|
| 1989 |
Wlodawer A, Miller M, Jaskólski M, Sathyanarayana BK, Baldwin E, Weber IT, Selk LM, Clawson L, Schneider J, Kent SB. Conserved folding in retroviral proteases: crystal structure of a synthetic HIV-1 protease. Science (New York, N.Y.). 245: 616-21. PMID 2548279 DOI: 10.1126/Science.2548279 |
0.406 |
|
| 1989 |
Neurath AR, Kent SB, Strick N, Parker K. Delineation of contiguous determinants essential for biological functions of the pre-S sequence of the hepatitis B virus envelope protein: its antigenicity, immunogenicity and cell-receptor recognition. Annales De L'Institut Pasteur. Virology. 139: 13-38. PMID 2462893 DOI: 10.1016/S0769-2617(88)80003-0 |
0.324 |
|
| 1988 |
Neurath AR, Strick N, Parker K, Kent SB. Antibodies recognizing human serum albumin are not elicited by immunization with preS2 sequences of the hepatitis B virus envelope protein. Journal of Medical Virology. 24: 137-51. PMID 3351483 DOI: 10.1002/Jmv.1890240203 |
0.309 |
|
| 1988 |
Schneider J, Kent SB. Enzymatic activity of a synthetic 99 residue protein corresponding to the putative HIV-1 protease. Cell. 54: 363-8. PMID 3293801 DOI: 10.1016/0092-8674(88)90199-7 |
0.395 |
|
| 1988 |
Sasaki A, Tempst P, Liotta AS, Margioris AN, Hood LE, Kent SB, Sato S, Shinkawa O, Yoshinaga K, Krieger DT. Isolation and characterization of a corticotropin-releasing hormone-like peptide from human placenta. The Journal of Clinical Endocrinology and Metabolism. 67: 768-73. PMID 3262120 DOI: 10.1210/Jcem-67-4-768 |
0.328 |
|
| 1988 |
Aebersold RH, Pipes G, Hood LE, Kent SB. N-terminal and internal sequence determination of microgram amounts of proteins separated by isoelectric focusing in immobilized pH gradients. Electrophoresis. 9: 520-30. PMID 3243248 DOI: 10.1002/Elps.1150090912 |
0.377 |
|
| 1988 |
Aebersold RH, Pipes GD, Nika H, Hood LE, Kent SB. Covalent immobilization of proteins for high-sensitivity sequence analysis: electroblotting onto chemically activated glass from sodium dodecyl sulfate-polyacrylamide gels. Biochemistry. 27: 6860-7. PMID 3196688 DOI: 10.1021/Bi00418A031 |
0.354 |
|
| 1988 |
Kappes JC, Morrow CD, Lee SW, Jameson BA, Kent SB, Hood LE, Shaw GM, Hahn BH. Identification of a novel retroviral gene unique to human immunodeficiency virus type 2 and simian immunodeficiency virus SIVMAC. Journal of Virology. 62: 3501-5. PMID 3136256 DOI: 10.1128/Jvi.62.9.3501-3505.1988 |
0.309 |
|
| 1988 |
Kent SB. Chemical synthesis of peptides and proteins. Annual Review of Biochemistry. 57: 957-89. PMID 3052294 DOI: 10.1146/Annurev.Bi.57.070188.004521 |
0.461 |
|
| 1988 |
Jameson BA, Rao PE, Kong LI, Hahn BH, Shaw GM, Hood LE, Kent SB. Location and chemical synthesis of a binding site for HIV-1 on the CD4 protein. Science (New York, N.Y.). 240: 1335-9. PMID 2453925 DOI: 10.1126/Science.2453925 |
0.332 |
|
| 1987 |
Neurath AR, Kent SB, Strick N, Parker K, Courouce AM, Riottot MM, Petit MA, Budkowska A, Girard M, Pillot J. Antibodies to synthetic peptides from the pre-S1 and pre-S2 regions of one subtype of the hepatitis B virus (HBV) envelope protein recognize all HBV subtypes. Molecular Immunology. 24: 975-80. PMID 3657811 DOI: 10.1016/0161-5890(87)90009-5 |
0.323 |
|
| 1987 |
Neurath AR, Kent SB, Adamowicz P, Riottot MM, Price P, Strick N, Parker K, Petit MA, Budkowska A, Girard M. Immunological cross-reactivity between preS2 sequences of the hepatitis B virus envelope proteins corresponding to serological subtypes adw2 and ayw. Molecular Immunology. 24: 561-8. PMID 3657796 DOI: 10.1016/0161-5890(87)90036-8 |
0.309 |
|
| 1987 |
Aebersold RH, Leavitt J, Saavedra RA, Hood LE, Kent SB. Internal amino acid sequence analysis of proteins separated by one- or two-dimensional gel electrophoresis after in situ protease digestion on nitrocellulose. Proceedings of the National Academy of Sciences of the United States of America. 84: 6970-4. PMID 3313383 DOI: 10.1073/Pnas.84.20.6970 |
0.405 |
|
| 1987 |
Neurath AR, Adamowicz P, Kent SB, Riottot MM, Strick N, Parker K, Offensperger W, Petit MA, Wahl S, Budkowska A. Characterization of monoclonal antibodies specific for the pre-S2 region of the hepatitis B virus envelope protein. Molecular Immunology. 23: 991-7. PMID 2431299 DOI: 10.1016/0161-5890(86)90130-6 |
0.34 |
|
| 1986 |
Tempst P, Woo DD, Teplow DB, Aebersold R, Hood LE, Kent SB. Microscale structure analysis of a high-molecular-weight, hydrophobic membrane glycoprotein fraction with platelet-derived growth factor-dependent kinase activity. Journal of Chromatography. 359: 403-12. PMID 3733938 DOI: 10.1016/0021-9673(86)80094-2 |
0.354 |
|
| 1986 |
Smith LM, Sanders JZ, Kaiser RJ, Hughes P, Dodd C, Connell CR, Heiner C, Kent SB, Hood LE. Fluorescence detection in automated DNA sequence analysis. Nature. 321: 674-9. PMID 3713851 DOI: 10.1038/321674A0 |
0.44 |
|
| 1986 |
Clark-Lewis I, Aebersold R, Ziltener H, Schrader JW, Hood LE, Kent SB. Automated chemical synthesis of a protein growth factor for hemopoietic cells, interleukin-3. Science (New York, N.Y.). 231: 134-9. PMID 3079915 DOI: 10.1126/Science.3079915 |
0.426 |
|
| 1986 |
Neurath AR, Kent SB, Strick N, Parker K. Identification and chemical synthesis of a host cell receptor binding site on hepatitis B virus. Cell. 46: 429-36. PMID 3015414 DOI: 10.1016/0092-8674(86)90663-X |
0.327 |
|
| 1986 |
Barry RA, Kent SB, McKinley MP, Meyer RK, DeArmond SJ, Hood LE, Prusiner SB. Scrapie and cellular prion proteins share polypeptide epitopes. The Journal of Infectious Diseases. 153: 848-54. PMID 2422294 DOI: 10.1093/Infdis/153.5.848 |
0.357 |
|
| 1985 |
Neurath AR, Kent SB, Strick N. Antibody response to two synthetic peptides corresponding to residues 45-68 and 69-79 of the major protein of hepatitis B surface antigen. Virus Research. 1: 321-31. PMID 6532005 DOI: 10.1016/0168-1702(84)90021-2 |
0.384 |
|
| 1985 |
Neurath AR, Kent SB, Strick N. Monoclonal antibodies to hepatitis B surface antigen (HBsAg) with anti-alpha specificity recognize a synthetic peptide analogue (S135-155) with unmodified lysine (141). Journal of Virological Methods. 9: 341-6. PMID 6442302 DOI: 10.1016/0166-0934(84)90059-4 |
0.384 |
|
| 1985 |
Neurath AR, Kent SB, Strick N, Stark D, Sproul P. Genetic restriction of immune responsiveness to synthetic peptides corresponding to sequences in the pre-S region of the hepatitis B virus (HBV) envelope gene. Journal of Medical Virology. 17: 119-25. PMID 4056755 DOI: 10.1002/Jmv.1890170204 |
0.316 |
|
| 1985 |
Neurath AR, Kent SB, Strick N, Taylor P, Stevens CE. Hepatitis B virus contains pre-S gene-encoded domains. Nature. 315: 154-6. PMID 2581144 DOI: 10.1038/315154A0 |
0.331 |
|
| 1985 |
Offensperger W, Wahl S, Neurath AR, Price P, Strick N, Kent SB, Christman JK, Acs G. Expression in Escherichia coli of a cloned DNA sequence encoding the pre-S2 region of hepatitis B virus. Proceedings of the National Academy of Sciences of the United States of America. 82: 7540-4. PMID 2415963 DOI: 10.1073/Pnas.82.22.7540 |
0.359 |
|
| 1984 |
Hunkapiller M, Kent S, Caruthers M, Dreyer W, Firca J, Giffin C, Horvath S, Hunkapiller T, Tempst P, Hood L. A microchemical facility for the analysis and synthesis of genes and proteins. Nature. 310: 105-11. PMID 6738709 DOI: 10.1038/310105A0 |
0.42 |
|
| 1984 |
Neurath AR, Kent SB, Strick N. Antibodies to hepatitis B surface antigen (HBsAg) elicited by immunization with a synthetic peptide covalently linked to liposomes. The Journal of General Virology. 1009-14. PMID 6202827 DOI: 10.1099/0022-1317-65-5-1009 |
0.337 |
|
| 1984 |
Neurath AR, Kent SB, Strick N. Location and chemical synthesis of a pre-S gene coded immunodominant epitope of hepatitis B virus. Science (New York, N.Y.). 224: 392-5. PMID 6200931 DOI: 10.1126/Science.6200931 |
0.34 |
|
| 1983 |
Kent SB, Merrifield RB. Chemical mechanism to account for artifactual formation of shortened peptides with free alpha-amino groups in solid phase peptide synthesis. International Journal of Peptide and Protein Research. 22: 57-65. PMID 6885250 DOI: 10.1111/J.1399-3011.1983.Tb02068.X |
0.575 |
|
| 1982 |
Dimarchi RD, Tam JP, Kent SB, Merrifield RB. Weak acid-catalyzed pyrrolidone carboxylic acid formation from glutamine during solid phase peptide synthesis. Minimization by rapid coupling. International Journal of Peptide and Protein Research. 19: 88-93. PMID 7118385 DOI: 10.1111/J.1399-3011.1982.Tb03027.X |
0.667 |
|
| 1981 |
Sarin VK, Kent SB, Tam JP, Merrifield RB. Quantitative monitoring of solid-phase peptide synthesis by the ninhydrin reaction. Analytical Biochemistry. 117: 147-57. PMID 7316187 DOI: 10.1016/0003-2697(81)90704-1 |
0.583 |
|
| 1979 |
Kent SB, Mitchell AR, Engelhard M, Merrifield RB. Mechanisms and prevention of trifluoroacetylation in solid-phase peptide synthesis. Proceedings of the National Academy of Sciences of the United States of America. 76: 2180-4. PMID 287055 DOI: 10.1073/Pnas.76.5.2180 |
0.59 |
|
| 1975 |
Browne DT, Kent SB. Formation of non-amidine products in the chemical modification of horse liver alcohol dehydrogenase with imido esters. Biochemical and Biophysical Research Communications. 67: 133-8. PMID 1010 DOI: 10.1016/0006-291X(75)90293-4 |
0.66 |
|
| 1975 |
Browne DT, Kent SB. Formation of non-amidine products in the reaction of primary amines with imido esters. Biochemical and Biophysical Research Communications. 67: 126-32. PMID 1009 DOI: 10.1016/0006-291X(75)90292-2 |
0.667 |
|
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