| Year |
Citation |
Score |
| 2021 |
LeRoith D, Holly JMP, Forbes BE. Insulin-like growth factors: Ligands, binding proteins, and receptors. Molecular Metabolism. 101245. PMID 33962049 DOI: 10.1016/j.molmet.2021.101245 |
0.408 |
|
| 2020 |
Gallagher EJ, LeRoith D. Hyperinsulinaemia in cancer. Nature Reviews. Cancer. PMID 32908223 DOI: 10.1038/S41568-020-0295-5 |
0.471 |
|
| 2020 |
Gallagher EJ, Fei K, Feldman SM, Port E, Friedman NB, Boolbol SK, Killelea B, Pilewskie M, Choi L, King T, Nayak A, Franco R, Cruz D, Antoniou IM, LeRoith D, et al. Insulin resistance contributes to racial disparities in breast cancer prognosis in US women. Breast Cancer Research : Bcr. 22: 40. PMID 32393319 DOI: 10.1186/S13058-020-01281-Y |
0.403 |
|
| 2020 |
Huang G, Song C, Wang N, Qin T, Sui S, Obr A, Zeng L, Wood TL, LeRoith D, Li M, Wu Y. RNA-binding protein CUGBP1 controls the differential INSR splicing in molecular subtypes of breast cancer cells and affects cell aggressiveness. Carcinogenesis. PMID 31958132 DOI: 10.1093/Carcin/Bgz141 |
0.338 |
|
| 2020 |
Kang C, Shlomai G, James A, Antoniou IM, Scully T, Ettela A, Kase NG, Wood T, LeRoith D, Gallagher EJ. SUN-131 The Roles of Two Insulin Receptor Isoforms in Triple Negative Breast Cancer Growth Journal of the Endocrine Society. 4. DOI: 10.1210/Jendso/Bvaa046.1817 |
0.406 |
|
| 2019 |
Sarfstein R, Nagaraj K, LeRoith D, Werner H. Differential Effects of Insulin and IGF1 Receptors on ERK and AKT Subcellular Distribution in Breast Cancer Cells. Cells. 8. PMID 31771180 DOI: 10.3390/Cells8121499 |
0.471 |
|
| 2019 |
Senapati P, Kato H, Lee M, Leung A, Thai C, Sanchez A, Gallagher EJ, LeRoith D, Seewaldt VL, Ann DK, Schones DE. Hyperinsulinemia promotes aberrant histone acetylation in triple-negative breast cancer. Epigenetics & Chromatin. 12: 44. PMID 31315653 DOI: 10.1186/S13072-019-0290-9 |
0.714 |
|
| 2019 |
Ran L, Wang X, Mi A, Liu Y, Wu J, Wang H, Guo M, Sun J, Liu B, Li Y, Wang D, Jiang R, Wang N, Gao W, Zeng L, ... ... LeRoith D, et al. Loss of Adipose Growth Hormone Receptor in Mice Enhances Local Fatty Acid Trapping and Impairs Brown Adipose Tissue Thermogenesis. Iscience. 16: 106-121. PMID 31154207 DOI: 10.1016/J.Isci.2019.05.020 |
0.347 |
|
| 2019 |
Robinson A, Lubitz I, Atrakchi-Baranes D, Licht-Murava A, Katsel P, Leroith D, Liraz-Zaltsman S, Haroutunian V, Beeri MS. Combination of Insulin with a GLP1 Agonist Is Associated with Better Memory and Normal Expression of Insulin Receptor Pathway Genes in a Mouse Model of Alzheimer's Disease. Journal of Molecular Neuroscience : Mn. PMID 30635783 DOI: 10.1007/S12031-019-1257-9 |
0.444 |
|
| 2019 |
FAYFMAN M, LEROITH D, PASQUEL FJ, ANZOLA I, URRUTIA MA, WANG H, UMPIERREZ GE. 382-P: Insulin Requirements after Hospital Discharge in Patients with Type 2 Diabetes Diabetes. 68: 382-P. DOI: 10.2337/Db19-382-P |
0.395 |
|
| 2019 |
BECKERMAN M, KARNIELI E, HAREL C, KLIP A, BILAN PJ, GALLAGHER E, LEROITH D, LEVENBERG S. 1172-P: GLUT4-Overexpressing Engineered Muscle Tissue Implants as a Potential Novel Therapy for Type 2 Diabetes: Lessons from Diabetic Mice Diabetes. 68: 1172-P. DOI: 10.2337/Db19-1172-P |
0.357 |
|
| 2018 |
Obr AE, Kumar S, Chang YJ, Bulatowicz JJ, Barnes BJ, Birge RB, Lazzarino DA, Gallagher E, LeRoith D, Wood TL. Insulin-like growth factor receptor signaling in breast tumor epithelium protects cells from endoplasmic reticulum stress and regulates the tumor microenvironment. Breast Cancer Research : Bcr. 20: 138. PMID 30458886 DOI: 10.1186/S13058-018-1063-2 |
0.414 |
|
| 2018 |
Kang C, LeRoith D, Gallagher EJ. Diabetes, obesity and breast cancer. Endocrinology. PMID 30215698 DOI: 10.1210/En.2018-00574 |
0.352 |
|
| 2018 |
Gallagher EJ, LeRoith D. World leaders describe the latest in IGF research. Journal of Molecular Endocrinology. 61: E1-E3. PMID 29875198 DOI: 10.1530/Jme-18-0106 |
0.432 |
|
| 2018 |
Liu YF, Paz K, Herschkovitz A, Alt A, Tennenbaum T, Sampson SR, Ohba M, Kuroki T, LeRoith D, Zick Y. Insulin stimulates PKCζ -mediated phosphorylation of insulin receptor substrate-1 (IRS-1): A self-attenuated mechanism to negatively regulate the function of IRS proteins. The Journal of Biological Chemistry. 293: 7264. PMID 29752417 DOI: 10.1074/jbc.W118.003466 |
0.345 |
|
| 2018 |
Arcidiacono D, Dedja A, Giacometti C, Fassan M, Nucci D, Francia S, Fabris F, Zaramella A, Gallagher EJ, Cassaro M, Rugge M, LeRoith D, Alberti A, Realdon S. Hyperinsulinemia Promotes Esophageal Cancer Development in a Surgically-Induced Duodeno-Esophageal Reflux Murine Model. International Journal of Molecular Sciences. 19. PMID 29662006 DOI: 10.3390/Ijms19041198 |
0.492 |
|
| 2017 |
Mosa R, Huang L, Wu Y, Fung C, Mallawakankanamalage O, LeRoith D, Chen C. Hexarelin, a Growth Hormone Secretagogue, Improves Lipid Metabolic Aberrations in Nonobese Insulin-Resistant Male MKR Mice. Endocrinology. 158: 3174-3187. PMID 28977588 DOI: 10.1210/En.2017-00168 |
0.408 |
|
| 2017 |
Mosa R, Huang L, Li H, Grist M, LeRoith D, Chen C. Long-term treatment with the ghrelin receptor antagonist, [D-Lys3]-GHRP-6 does not improve glucose homeostasis in non-obese diabetic MKR mice. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. ajpregu.00157.2017. PMID 28903914 DOI: 10.1152/Ajpregu.00157.2017 |
0.422 |
|
| 2017 |
Shlomai G, Zelenko Z, Antoniou IM, Stasinopoulos M, Tobin-Hess A, Vitek MP, LeRoith D, Gallagher EJ. OP449 inhibits breast cancer growth without adverse metabolic effects. Endocrine-Related Cancer. 24: 519-529. PMID 28830934 DOI: 10.1530/Erc-17-0077 |
0.371 |
|
| 2017 |
Gallagher EJ, Zelenko Z, Tobin-Hess A, Werner U, Tennagels N, LeRoith D. Erratum to: Non-metabolisable insulin glargine does not promote breast cancer growth in a mouse model of type 2 diabetes. Diabetologia. PMID 28229179 DOI: 10.1007/S00125-017-4225-3 |
0.432 |
|
| 2016 |
Shlomai G, Neel B, LeRoith D, Gallagher EJ. Type 2 Diabetes Mellitus and Cancer: The Role of Pharmacotherapy. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 34: 4261-4269. PMID 27903154 DOI: 10.1200/Jco.2016.67.4044 |
0.345 |
|
| 2016 |
Zelenko Z, Gallagher EJ, Tobin-Hess A, Belardi V, Rostoker R, Blank J, Dina Y, LeRoith D. Silencing vimentin expression decreases pulmonary metastases in a pre-diabetic mouse model of mammary tumor progression. Oncogene. 36: 1394-1403. PMID 27568979 DOI: 10.1038/Onc.2016.305 |
0.363 |
|
| 2016 |
Werner H, Sarfstein R, LeRoith D, Bruchim I. Insulin-like Growth Factor 1 Signaling Axis Meets p53 Genome Protection Pathways. Frontiers in Oncology. 6: 159. PMID 27446805 DOI: 10.3389/Fonc.2016.00159 |
0.435 |
|
| 2016 |
Zelenko Z, Gallagher EJ, Antoniou IM, Sachdev D, Nayak A, Yee D, LeRoith D. EMT Reversal in human cancer cells after IR knockdown in hyperinsulinemic mice. Endocrine-Related Cancer. PMID 27435064 DOI: 10.1530/Erc-16-0142 |
0.441 |
|
| 2016 |
Gallagher EJ, Zelenko Z, Tobin-Hess A, Werner U, Tennagels N, LeRoith D. Non-metabolisable insulin glargine does not promote breast cancer growth in a mouse model of type 2 diabetes. Diabetologia. PMID 27241182 DOI: 10.1007/s00125-016-4000-x |
0.322 |
|
| 2016 |
Rostoker R, Ben-Shmuel S, Rashed R, Shen Orr Z, LeRoith D. CD24 cell surface expression in Mvt1 mammary cancer cells serves as a biomarker for sensitivity to anti-IGF1R therapy. Breast Cancer Research : Bcr. 18: 51. PMID 27179633 DOI: 10.1186/S13058-016-0711-7 |
0.364 |
|
| 2016 |
Gallagher EJ, LeRoith D, Franco R, Antoniou IM, Nayak A, Livaudais-Toman J, Bickell N. Metabolic syndrome and pre-diabetes contribute to racial disparities in breast cancer outcomes: hypothesis and proposed pathways. Diabetes/Metabolism Research and Reviews. PMID 26896340 DOI: 10.1002/Dmrr.2795 |
0.34 |
|
| 2016 |
Ben-Shmuel S, Rostoker R, Scheinman EJ, LeRoith D. Metabolic Syndrome, Type 2 Diabetes, and Cancer: Epidemiology and Potential Mechanisms. Handbook of Experimental Pharmacology. 233: 355-72. PMID 25903410 DOI: 10.1007/164_2015_12 |
0.328 |
|
| 2016 |
Gallagher E, Leroith D, Feldman SM, Port ER, Friedman N, Pilewskie ML, Estabrook A, Boolbol SK, Franco R, Fei K, Bickell NA. Are racial differences in obesity and insulin resistance related to aggressive breast cancer? Journal of Clinical Oncology. 34: 1568-1568. DOI: 10.1200/Jco.2016.34.15_Suppl.1568 |
0.36 |
|
| 2015 |
Cefalu WT, Rosenstock J, LeRoith D, Riddle MC. Insulin's Role in Diabetes Management: After 90 Years, Still Considered the Essential "Black Dress". Diabetes Care. 38: 2200-3. PMID 26604276 DOI: 10.2337/Dci15-0023 |
0.423 |
|
| 2015 |
Ben-Shmuel S, Scheinman EJ, Rashed R, Orr ZS, Gallagher EJ, LeRoith D, Rostoker R. Ovariectomy is associated with metabolic impairments and enhanced mammary tumor growth in MKR mice. The Journal of Endocrinology. 227: 143-51. PMID 26383532 DOI: 10.1530/Joe-15-0310 |
0.408 |
|
| 2015 |
Gallagher EJ, LeRoith D. Obesity and diabetes: The increased risk of cancer and cancer-related mortality Physiological Reviews. 95: 727-748. PMID 26084689 DOI: 10.1152/Physrev.00030.2014 |
0.308 |
|
| 2015 |
Rostoker R, Abelson S, Bitton-Worms K, Genkin I, Ben-Shmuel S, Dakwar M, Orr ZS, Caspi A, Tzukerman M, LeRoith D. Highly specific role of the insulin receptor in breast cancer progression. Endocrine-Related Cancer. 22: 145-57. PMID 25694511 DOI: 10.1530/Erc-14-0490 |
0.429 |
|
| 2014 |
Scheinman EJ, Damouni R, Caspi A, Shen-Orr Z, Tiosano D, LeRoith D. The beneficial effect of growth hormone treatment on islet mass in streptozotocin-treated mice. Diabetes/Metabolism Research and Reviews. PMID 25529355 DOI: 10.1002/dmrr.2631 |
0.36 |
|
| 2014 |
Home P, Riddle M, Cefalu WT, Bailey CJ, Bretzel RG, Del Prato S, Leroith D, Schernthaner G, van Gaal L, Raz I. Response to comment on Home et al. Insulin therapy in people with type 2 diabetes: opportunities and challenges? Diabetes care 2014;37:1499-1508. Diabetes Care. 37: e247. PMID 25342843 DOI: 10.2337/Dc14-1790 |
0.328 |
|
| 2014 |
Stewart MH, Gutierrez-Martinez P, Beerman I, Garrison B, Gallagher EJ, LeRoith D, Rossi DJ. Growth hormone receptor signaling is dispensable for HSC function and aging. Blood. 124: 3076-80. PMID 25274507 DOI: 10.1182/Blood-2014-05-575308 |
0.315 |
|
| 2014 |
Cefalu WT, Buse JB, Del Prato S, Home PD, LeRoith D, Nauck MA, Raz I, Rosenstock J, Riddle MC. Beyond metformin: safety considerations in the decision-making process for selecting a second medication for type 2 diabetes management: reflections from a diabetes care editors' expert forum. Diabetes Care. 37: 2647-59. PMID 25147257 DOI: 10.2337/Dc14-1395 |
0.321 |
|
| 2014 |
Rota LM, Albanito L, Shin ME, Goyeneche CL, Shushanov S, Gallagher EJ, LeRoith D, Lazzarino DA, Wood TL. IGF1R inhibition in mammary epithelia promotes canonical Wnt signaling and Wnt1-driven tumors. Cancer Research. 74: 5668-79. PMID 25092896 DOI: 10.1158/0008-5472.Can-14-0970 |
0.352 |
|
| 2014 |
Home P, Riddle M, Cefalu WT, Bailey CJ, Bretzel RG, Del Prato S, Leroith D, Schernthaner G, van Gaal L, Raz I. Insulin therapy in people with type 2 diabetes: opportunities and challenges? Diabetes Care. 37: 1499-508. PMID 24855154 DOI: 10.2337/Dc13-2743 |
0.428 |
|
| 2014 |
Leroith D. microRNAs: what the clinician should know about this new frontier. Diabetes Care. 37: 1176-7. PMID 24757222 DOI: 10.2337/Dc13-3050 |
0.399 |
|
| 2014 |
Mallipattu SK, Gallagher EJ, LeRoith D, Liu R, Mehrotra A, Horne SJ, Chuang PY, Yang VW, He JC. Diabetic nephropathy in a nonobese mouse model of type 2 diabetes mellitus. American Journal of Physiology. Renal Physiology. 306: F1008-17. PMID 24598803 DOI: 10.1152/Ajprenal.00597.2013 |
0.343 |
|
| 2014 |
Werner H, LeRoith D. Insulin and insulin-like growth factor receptors in the brain: physiological and pathological aspects. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 24: 1947-53. PMID 24529663 DOI: 10.1016/j.euroneuro.2014.01.020 |
0.397 |
|
| 2014 |
Rostoker R, Abelson S, Bitton-Worms K, Genkin I, Ben-Shmuel S, Caspi A, Tzukerman M, LeRoith D. GP2-3: The role of the insulin receptor in breast cancer progression Growth Hormone & Igf Research. 24: S27-S28. DOI: 10.1016/S1096-6374(14)50070-6 |
0.396 |
|
| 2014 |
Wood T, Rota L, Albanito L, Shin M, Goyeneche C, Shushanov S, Gallagher E, Leroith D, Lazzarino D. OR8-2: Insulin-like growth factor receptor inhibition in mammary epithelium enhances Wnt1- mediated tumors, canonical Wnt signaling and IGF-II/insulin-receptor A expression Growth Hormone & Igf Research. 24: S21-S22. DOI: 10.1016/S1096-6374(14)50056-1 |
0.496 |
|
| 2013 |
Belardi V, Gallagher EJ, Novosyadlyy R, Leroith D. Insulin and IGFs in obesity-related breast cancer Journal of Mammary Gland Biology and Neoplasia. 18: 277-289. PMID 24154546 DOI: 10.1007/S10911-013-9303-7 |
0.51 |
|
| 2013 |
Vijayakumar A, Buffin NJ, Gallagher EJ, Blank J, Wu Y, Yakar S, LeRoith D. Deletion of growth hormone receptors in postnatal skeletal muscle of male mice does not alter muscle mass and response to pathological injury. Endocrinology. 154: 3776-83. PMID 23861377 DOI: 10.1210/En.2013-1209 |
0.344 |
|
| 2013 |
Gallagher EJ, Alikhani N, Tobin-Hess A, Blank J, Buffin NJ, Zelenko Z, Tennagels N, Werner U, LeRoith D. Insulin receptor phosphorylation by endogenous insulin or the insulin analog AspB10 promotes mammary tumor growth independent of the IGF-I receptor. Diabetes. 62: 3553-60. PMID 23835331 DOI: 10.2337/Db13-0249 |
0.485 |
|
| 2013 |
Ferguson RD, Gallagher EJ, Scheinman EJ, Damouni R, LeRoith D. The epidemiology and molecular mechanisms linking obesity, diabetes, and cancer. Vitamins and Hormones. 93: 51-98. PMID 23810003 DOI: 10.1016/B978-0-12-416673-8.00010-1 |
0.337 |
|
| 2013 |
Gallagher EJ, LeRoith D. Does a single nucleotide polymorphism in the FGFR explain the connection between diabetes and cancer? Cell Metabolism. 17: 808-9. PMID 23747238 DOI: 10.1016/J.Cmet.2013.05.006 |
0.381 |
|
| 2013 |
Dynkevich Y, Rother KI, Whitford I, Qureshi S, Galiveeti S, Szulc AL, Danoff A, Breen TL, Kaviani N, Shanik MH, Leroith D, Vigneri R, Koch CA, Roth J. Tumors, IGF-2, and hypoglycemia: insights from the clinic, the laboratory, and the historical archive. Endocrine Reviews. 34: 798-826. PMID 23671155 DOI: 10.1210/Er.2012-1033 |
0.485 |
|
| 2013 |
Ferguson RD, Gallagher EJ, Cohen D, Tobin-Hess A, Alikhani N, Novosyadlyy R, Haddad N, Yakar S, LeRoith D. Hyperinsulinemia promotes metastasis to the lung in a mouse model of Her2-mediated breast cancer. Endocrine-Related Cancer. 20: 391-401. PMID 23572162 DOI: 10.1530/Erc-12-0333 |
0.351 |
|
| 2013 |
Bechmann LP, Vetter D, Ishida J, Hannivoort RA, Lang UE, Kocabayoglu P, Fiel MI, Muñoz U, Patman GL, Ge F, Yakar S, Li X, Agius L, Lee YM, Zhang W, ... ... LeRoith D, et al. Post-transcriptional activation of PPAR alpha by KLF6 in hepatic steatosis. Journal of Hepatology. 58: 1000-6. PMID 23353867 DOI: 10.1016/J.Jhep.2013.01.020 |
0.378 |
|
| 2013 |
Alikhani N, Ferguson RD, Novosyadlyy R, Gallagher EJ, Scheinman EJ, Yakar S, LeRoith D. Mammary tumor growth and pulmonary metastasis are enhanced in a hyperlipidemic mouse model. Oncogene. 32: 961-7. PMID 22469977 DOI: 10.1038/Onc.2012.113 |
0.329 |
|
| 2013 |
Autier P, Koechlin A, Robertson C, Bota M, Boniol M, Leroith D, Bolli G, Rosenstock J, Boyle P. Breast cancer and diabetes. Journal of Clinical Oncology. 31: e12507-e12507. DOI: 10.1200/Jco.2013.31.15_Suppl.E12507 |
0.305 |
|
| 2012 |
Hursting SD, Digiovanni J, Dannenberg AJ, Azrad M, Leroith D, Demark-Wahnefried W, Kakarala M, Brodie A, Berger NA. Obesity, energy balance, and cancer: new opportunities for prevention. Cancer Prevention Research (Philadelphia, Pa.). 5: 1260-72. PMID 23034147 DOI: 10.1158/1940-6207.Capr-12-0140 |
0.33 |
|
| 2012 |
Vijayakumar A, Wu Y, Buffin NJ, Li X, Sun H, Gordon RE, Yakar S, LeRoith D. Skeletal muscle growth hormone receptor signaling regulates basal, but not fasting-induced, lipid oxidation. Plos One. 7: e44777. PMID 23024761 DOI: 10.1371/Journal.Pone.0044777 |
0.301 |
|
| 2012 |
LeRoith D. Insulin-Like growth factors in health and disease. Foreword. Endocrinology and Metabolism Clinics of North America. 41: xi-xiii. PMID 22682640 DOI: 10.1016/J.Ecl.2012.04.022 |
0.427 |
|
| 2012 |
Cohen DH, LeRoith D. Obesity, type 2 diabetes, and cancer: the insulin and IGF connection. Endocrine-Related Cancer. 19: F27-45. PMID 22593429 DOI: 10.1530/Erc-11-0374 |
0.427 |
|
| 2012 |
Leroith D. Insulin therapy. Foreword. Endocrinology and Metabolism Clinics of North America. 41: ix-xi. PMID 22575414 DOI: 10.1016/J.Ecl.2012.03.005 |
0.405 |
|
| 2012 |
Corrêa-Giannella ML, de Azevedo MR, Leroith D, Giannella-Neto D. Fibronectin glycation increases IGF-I induced proliferation of human aortic smooth muscle cells. Diabetology & Metabolic Syndrome. 4: 19. PMID 22553932 DOI: 10.1186/1758-5996-4-19 |
0.462 |
|
| 2012 |
Periyasamy-Thandavan S, Takhar S, Singer A, Dohn MR, Jackson WH, Welborn AE, LeRoith D, Marrero M, Thangaraju M, Huang S, Schoenlein PV. Insulin-like growth factor 1 attenuates antiestrogen- and antiprogestin-induced apoptosis in ER+ breast cancer cells by MEK1 regulation of the BH3-only pro-apoptotic protein Bim. Breast Cancer Research : Bcr. 14: R52. PMID 22429491 DOI: 10.1186/Bcr3153 |
0.413 |
|
| 2012 |
Novosyadlyy R, Leroith D. Insulin-like growth factors and insulin: at the crossroad between tumor development and longevity. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 67: 640-51. PMID 22421704 DOI: 10.1093/Gerona/Gls065 |
0.464 |
|
| 2012 |
Ferguson RD, Novosyadlyy R, Fierz Y, Alikhani N, Sun H, Yakar S, Leroith D. Hyperinsulinemia enhances c-Myc-mediated mammary tumor development and advances metastatic progression to the lung in a mouse model of type 2 diabetes. Breast Cancer Research : Bcr. 14: R8. PMID 22226054 DOI: 10.1186/Bcr3089 |
0.339 |
|
| 2012 |
Areshkov PO, Avdieiev SS, Balynska OV, Leroith D, Kavsan VM. Two closely related human members of chitinase-like family, CHI3L1 and CHI3L2, activate ERK1/2 in 293 and U373 cells but have the different influence on cell proliferation. International Journal of Biological Sciences. 8: 39-48. PMID 22211103 DOI: 10.7150/Ijbs.8.39 |
0.361 |
|
| 2012 |
Vijayakumar A, Wu Y, Sun H, Li X, Jeddy Z, Liu C, Schwartz GJ, Yakar S, LeRoith D. Targeted loss of GHR signaling in mouse skeletal muscle protects against high-fat diet-induced metabolic deterioration. Diabetes. 61: 94-103. PMID 22187377 DOI: 10.2337/Db11-0814 |
0.34 |
|
| 2012 |
Troncoso R, Vicencio JM, Parra V, Nemchenko A, Kawashima Y, Del Campo A, Toro B, Battiprolu PK, Aranguiz P, Chiong M, Yakar S, Gillette TG, Hill JA, Abel ED, Leroith D, et al. Energy-preserving effects of IGF-1 antagonize starvation-induced cardiac autophagy. Cardiovascular Research. 93: 320-9. PMID 22135164 DOI: 10.1093/Cvr/Cvr321 |
0.331 |
|
| 2012 |
Gallagher EJ, Fierz Y, Vijayakumar A, Haddad N, Yakar S, LeRoith D. Inhibiting PI3K reduces mammary tumor growth and induces hyperglycemia in a mouse model of insulin resistance and hyperinsulinemia. Oncogene. 31: 3213-22. PMID 22037215 DOI: 10.1038/Onc.2011.495 |
0.385 |
|
| 2012 |
Phillip M, Segeve Y, Zung A, Kowarski AA, Werner H, Roberts CT, Leroith D, Ladas J, Mulroney SE. The accumulation of IGF-I in kidneys of streptozotocin-diabetic adult rats is not associated with elevated plasma GH or IGF-I levels. Endocrine. 3: 689-93. PMID 21153228 DOI: 10.1007/Bf02746346 |
0.361 |
|
| 2012 |
Boyle P, Boniol M, Koechlin A, Bota M, Robertson C, Leroith D, Rosenstock J, Bolli G, Autier P. Abstract P4-13-08: Diabetes, Related Factors and Breast Cancer Risk Cancer Research. 72. DOI: 10.1158/0008-5472.Sabcs12-P4-13-08 |
0.312 |
|
| 2011 |
Leroith D, Scheinman EJ, Bitton-Worms K. The Role of Insulin and Insulin-like Growth Factors in the Increased Risk of Cancer in Diabetes. Rambam Maimonides Medical Journal. 2: e0043. PMID 23908801 DOI: 10.5041/Rmmj.10043 |
0.519 |
|
| 2011 |
Vijayakumar A, Yakar S, Leroith D. The intricate role of growth hormone in metabolism. Frontiers in Endocrinology. 2: 32. PMID 22654802 DOI: 10.3389/Fendo.2011.00032 |
0.447 |
|
| 2011 |
Gallagher EJ, LeRoith D. Diabetes, cancer, and metformin: connections of metabolism and cell proliferation. Annals of the New York Academy of Sciences. 1243: 54-68. PMID 22211893 DOI: 10.1111/J.1749-6632.2011.06285.X |
0.433 |
|
| 2011 |
Braun S, Bitton-Worms K, LeRoith D. The link between the metabolic syndrome and cancer. International Journal of Biological Sciences. 7: 1003-15. PMID 21912508 DOI: 10.7150/Ijbs.7.1003 |
0.355 |
|
| 2011 |
Landau D, Biada J, Chen Y, Sood S, Yakar S, Leroith D, Segev Y, Rabkin R. A marked deficiency in circulating and renal IGF-I peptide does not inhibit compensatory renal enlargement in uninephrectomized mice. Growth Hormone & Igf Research : Official Journal of the Growth Hormone Research Society and the International Igf Research Society. 21: 279-84. PMID 21862442 DOI: 10.1016/J.Ghir.2011.07.008 |
0.304 |
|
| 2011 |
Gallagher EJ, Leroith D, Karnieli E. The metabolic syndrome--from insulin resistance to obesity and diabetes. The Medical Clinics of North America. 95: 855-73. PMID 21855696 DOI: 10.1016/J.Mcna.2011.06.001 |
0.303 |
|
| 2011 |
Sun Z, Shushanov S, LeRoith D, Wood TL. Decreased IGF type 1 receptor signaling in mammary epithelium during pregnancy leads to reduced proliferation, alveolar differentiation, and expression of insulin receptor substrate (IRS)-1 and IRS-2. Endocrinology. 152: 3233-45. PMID 21628386 DOI: 10.1210/En.2010-1296 |
0.401 |
|
| 2011 |
Wu Y, Liu C, Sun H, Vijayakumar A, Giglou PR, Qiao R, Oppenheimer J, Yakar S, LeRoith D. Growth hormone receptor regulates β cell hyperplasia and glucose-stimulated insulin secretion in obese mice. The Journal of Clinical Investigation. 121: 2422-6. PMID 21555853 DOI: 10.1172/Jci45027 |
0.472 |
|
| 2011 |
Gallagher EJ, LeRoith D. Minireview: IGF, Insulin, and Cancer. Endocrinology. 152: 2546-51. PMID 21540285 DOI: 10.1210/En.2011-0231 |
0.508 |
|
| 2011 |
Gallagher EJ, LeRoith D. Is growth hormone resistance/IGF-1 reduction good for you? Cell Metabolism. 13: 355-356. PMID 21459318 DOI: 10.1016/J.Cmet.2011.03.003 |
0.499 |
|
| 2011 |
Li X, Wu X, Camacho R, Schwartz GJ, LeRoith D. Intracerebroventricular leptin infusion improves glucose homeostasis in lean type 2 diabetic MKR mice via hepatic vagal and non-vagal mechanisms. Plos One. 6: e17058. PMID 21379576 DOI: 10.1371/Journal.Pone.0017058 |
0.432 |
|
| 2011 |
Cannata D, Vijayakumar A, Fierz Y, LeRoith D. The GH/IGF-1 axis in growth and development: new insights derived from animal models. Advances in Pediatrics. 57: 331-51. PMID 21056746 DOI: 10.1016/J.Yapd.2010.09.003 |
0.383 |
|
| 2011 |
Gallagher EJ, Leroith D, Karnieli E. Insulin resistance in obesity as the underlying cause for the metabolic syndrome. The Mount Sinai Journal of Medicine, New York. 77: 511-23. PMID 20960553 DOI: 10.1002/Msj.20212 |
0.409 |
|
| 2011 |
Cannata D, Fierz Y, Vijayakumar A, LeRoith D. Type 2 diabetes and cancer: what is the connection? The Mount Sinai Journal of Medicine, New York. 77: 197-213. PMID 20309918 DOI: 10.1002/Msj.20167 |
0.425 |
|
| 2011 |
Buckley R, LeRoith D. Obesity, Type 2 Diabetes, and Cancer: The Insulin and Insulin-Like Growth Factor Connection Md Conference Express. 11: 4-5. DOI: 10.1177/155989771105001 |
0.361 |
|
| 2011 |
Leroith D, Blakesley VA, Werner H. Molecular Mechanisms of Insulin-like Growth Factor I Receptor Function: Implications for Normal Physiology and Pathological States Comprehensive Physiology. DOI: 10.1002/Cphy.Cp070520 |
0.506 |
|
| 2010 |
LeRoith D. Can endogenous hyperinsulinaemia explain the increased risk of cancer development and mortality in type 2 diabetes: evidence from mouse models. Diabetes/Metabolism Research and Reviews. 26: 599-601. PMID 20941806 DOI: 10.1002/Dmrr.1139 |
0.358 |
|
| 2010 |
Cannata D, Lann D, Wu Y, Elis S, Sun H, Yakar S, Lazzarino DA, Wood TL, Leroith D. Elevated circulating IGF-I promotes mammary gland development and proliferation. Endocrinology. 151: 5751-61. PMID 20926579 DOI: 10.1210/En.2010-0792 |
0.378 |
|
| 2010 |
LeRoith D. IGF-I: panacea or poison? The Journal of Clinical Endocrinology and Metabolism. 95: 4549-51. PMID 20926541 DOI: 10.1210/Jc.2010-1737 |
0.455 |
|
| 2010 |
Fierz Y, Novosyadlyy R, Vijayakumar A, Yakar S, LeRoith D. Mammalian target of rapamycin inhibition abrogates insulin-mediated mammary tumor progression in type 2 diabetes. Endocrine-Related Cancer. 17: 941-51. PMID 20801951 DOI: 10.1677/Erc-10-0091 |
0.377 |
|
| 2010 |
Gallagher EJ, LeRoith D. The proliferating role of insulin and insulin-like growth factors in cancer. Trends in Endocrinology and Metabolism: Tem. 21: 610-8. PMID 20663687 DOI: 10.1016/J.Tem.2010.06.007 |
0.53 |
|
| 2010 |
Vaitheesvaran B, LeRoith D, Kurland IJ. MKR mice have increased dynamic glucose disposal despite metabolic inflexibility, and hepatic and peripheral insulin insensitivity. Diabetologia. 53: 2224-32. PMID 20577711 DOI: 10.1007/S00125-010-1827-4 |
0.369 |
|
| 2010 |
Heron-Milhavet L, Mamaeva D, LeRoith D, Lamb NJ, Fernandez A. Impaired muscle regeneration and myoblast differentiation in mice with a muscle-specific KO of IGF-IR. Journal of Cellular Physiology. 225: 1-6. PMID 20458740 DOI: 10.1002/Jcp.22218 |
0.317 |
|
| 2010 |
Gallagher EJ, LeRoith D. Insulin, insulin resistance, obesity, and cancer. Current Diabetes Reports. 10: 93-100. PMID 20425567 DOI: 10.1007/S11892-010-0101-Y |
0.407 |
|
| 2010 |
Novosyadlyy R, Lann DE, Vijayakumar A, Rowzee A, Lazzarino DA, Fierz Y, Carboni JM, Gottardis MM, Pennisi PA, Molinolo AA, Kurshan N, Mejia W, Santopietro S, Yakar S, Wood TL, ... LeRoith D, et al. Insulin-mediated acceleration of breast cancer development and progression in a nonobese model of type 2 diabetes. Cancer Research. 70: 741-51. PMID 20068149 DOI: 10.1158/0008-5472.Can-09-2141 |
0.48 |
|
| 2010 |
Fierz Y, Novosyadlyy R, Vijayakumar A, Yakar S, LeRoith D. Insulin-sensitizing therapy attenuates type 2 diabetes-mediated mammary tumor progression. Diabetes. 59: 686-93. PMID 19959755 DOI: 10.2337/Db09-1291 |
0.395 |
|
| 2010 |
Vijayakumar A, Novosyadlyy R, Wu Y, Yakar S, LeRoith D. Biological effects of growth hormone on carbohydrate and lipid metabolism. Growth Hormone & Igf Research : Official Journal of the Growth Hormone Research Society and the International Igf Research Society. 20: 1-7. PMID 19800274 DOI: 10.1016/J.Ghir.2009.09.002 |
0.373 |
|
| 2010 |
Fierz Y, Novosyadlyy R, Vijayakumar A, Yakar S, LeRoith D. P35 Reduced serum IGF-1 levels do not affect insulin-mediated mammary tumor progression in type 2 diabetes Growth Hormone & Igf Research. 20: S52. DOI: 10.1016/S1096-6374(10)70135-0 |
0.436 |
|
| 2010 |
Lazzarino D, Rota L, Shushanov S, Ludwig D, LeRoith D, Wood T. OR10,57 Insulin-like growth factor signaling regulates stem/progenitor cells in the epithelium of virgin mouse mammary glands Growth Hormone & Igf Research. 20: S26. DOI: 10.1016/S1096-6374(10)70071-X |
0.428 |
|
| 2010 |
Cannata D, Lann D, Wu Y, Lazzarino D, Sun H, Yakar S, Wood T, LeRoith D. OR8,44 Increased levels of circulating IGF-I normalizes mammary gland development in mice deficient of local IGF-1 Growth Hormone & Igf Research. 20: S20. DOI: 10.1016/S1096-6374(10)70056-3 |
0.356 |
|
| 2010 |
Vijayakumar A, Wu Y, Sun H, Liu C, Haddad N, Yakar S, LeRoith D. OR1,2 Targeted ablation of growth hormone receptors in the skeletal muscle improves metabolism and protects against diet-induced obesity in mice Growth Hormone & Igf Research. 20: S2. DOI: 10.1016/S1096-6374(10)70008-3 |
0.328 |
|
| 2010 |
Wu Y, Sun H, Vijayakumar A, Yao S, Liu C, Yakar S, LeRoith D. OR1,1 b cell specific disruption of the growth hormone receptor impair b cell insulin secretion Growth Hormone & Igf Research. 20: S2. DOI: 10.1016/S1096-6374(10)70007-1 |
0.424 |
|
| 2009 |
Novosyadlyy R, Vijayakumar A, Lann D, Fierz Y, Kurshan N, LeRoith D. Physical and functional interaction between polyoma virus middle T antigen and insulin and IGF-I receptors is required for oncogene activation and tumour initiation. Oncogene. 28: 3477-86. PMID 19617901 DOI: 10.1038/Onc.2009.209 |
0.497 |
|
| 2009 |
Wu Y, Sun H, Yakar S, LeRoith D. Elevated levels of insulin-like growth factor (IGF)-I in serum rescue the severe growth retardation of IGF-I null mice. Endocrinology. 150: 4395-403. PMID 19497975 DOI: 10.1210/En.2009-0272 |
0.453 |
|
| 2009 |
Kawashima Y, Chen J, Sun H, Lann D, Hajjar RJ, Yakar S, Leroith D. Apolipoprotein E deficiency abrogates insulin resistance in a mouse model of type 2 diabetes mellitus. Diabetologia. 52: 1434-41. PMID 19436992 DOI: 10.1007/S00125-009-1378-8 |
0.39 |
|
| 2009 |
Hong SH, Briggs J, Newman R, Hoffman K, Mendoza A, LeRoith D, Helman L, Yakar S, Khanna C. Murine osteosarcoma primary tumour growth and metastatic progression is maintained after marked suppression of serum insulin-like growth factor I. International Journal of Cancer. Journal International Du Cancer. 124: 2042-9. PMID 19132750 DOI: 10.1002/Ijc.24169 |
0.44 |
|
| 2009 |
LeRoith D. Insulin-like growth factors and the brain. Endocrinology. 149: 5951. PMID 19022901 DOI: 10.1210/En.2008-1190 |
0.478 |
|
| 2009 |
Yakar S, Rosen CJ, Bouxsein ML, Sun H, Mejia W, Kawashima Y, Wu Y, Emerton K, Williams V, Jepsen K, Schaffler MB, Majeska RJ, Gavrilova O, Gutierrez M, Hwang D, ... ... LeRoith D, et al. Serum complexes of insulin-like growth factor-1 modulate skeletal integrity and carbohydrate metabolism. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 23: 709-19. PMID 18952711 DOI: 10.1096/Fj.08-118976 |
0.448 |
|
| 2009 |
Lim GE, Huang GJ, Flora N, LeRoith D, Rhodes CJ, Brubaker PL. Insulin regulates glucagon-like peptide-1 secretion from the enteroendocrine L cell. Endocrinology. 150: 580-91. PMID 18818290 DOI: 10.1210/En.2008-0726 |
0.462 |
|
| 2009 |
Paz K, Hemi R, LeRoith D, Karasik A, Kanety H, Zick Y. Molecular basis for insulin resistance: elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation Experimental and Clinical Endocrinology & Diabetes. 105: 10-10. DOI: 10.1055/S-0029-1211820 |
0.355 |
|
| 2009 |
Koval AP, Blakesley VA, Zick Y, LeRoith D. O-34: Characterization of the specific interaction of Crk with the IGF-I receptor Experimental and Clinical Endocrinology & Diabetes. 104: 44-45. DOI: 10.1055/S-0029-1211525 |
0.322 |
|
| 2009 |
Blakesley V, Esposito DL, Scrimgeour AG, Koval AP, Stannard BS, LeRoith D. O-12: Roles of the tyrosine residues in the carboxyterminal domain of the IGF-I receptor Experimental and Clinical Endocrinology & Diabetes. 104: 19-21. DOI: 10.1055/S-0029-1211503 |
0.316 |
|
| 2008 |
Lann D, LeRoith D. The role of endocrine insulin-like growth factor-I and insulin in breast cancer. Journal of Mammary Gland Biology and Neoplasia. 13: 371-9. PMID 19030972 DOI: 10.1007/S10911-008-9100-X |
0.345 |
|
| 2008 |
Kim J, Wende AR, Sena S, Theobald HA, Soto J, Sloan C, Wayment BE, Litwin SE, Holzenberger M, LeRoith D, Abel ED. Insulin-like growth factor I receptor signaling is required for exercise-induced cardiac hypertrophy. Molecular Endocrinology (Baltimore, Md.). 22: 2531-43. PMID 18801929 DOI: 10.1210/Me.2008-0265 |
0.386 |
|
| 2008 |
Serrano ML, Sánchez-Gómez M, Bravo MM, Yakar S, LeRoith D. Differential expression of IGF-I and insulin receptor isoforms in HPV positive and negative human cervical cancer cell lines. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme. 40: 661-7. PMID 18711691 DOI: 10.1055/S-0028-1109215 |
0.393 |
|
| 2008 |
Toyoshima Y, Monson C, Duan C, Wu Y, Gao C, Yakar S, Sadler KC, LeRoith D. The role of insulin receptor signaling in zebrafish embryogenesis. Endocrinology. 149: 5996-6005. PMID 18687786 DOI: 10.1210/En.2008-0329 |
0.479 |
|
| 2008 |
Moore T, Carbajal S, Beltran L, Perkins SN, Yakar S, Leroith D, Hursting SD, Digiovanni J. Reduced susceptibility to two-stage skin carcinogenesis in mice with low circulating insulin-like growth factor I levels. Cancer Research. 68: 3680-8. PMID 18483250 DOI: 10.1158/0008-5472.Can-07-6271 |
0.416 |
|
| 2008 |
LeRoith D. Dyslipidemia and glucose dysregulation in overweight and obese patients. Clinical Cornerstone. 8: 38-52. PMID 18452841 DOI: 10.1016/S1098-3597(07)80027-5 |
0.322 |
|
| 2008 |
Anzo M, Cobb LJ, Hwang DL, Mehta H, Said JW, Yakar S, LeRoith D, Cohen P. Targeted deletion of hepatic Igf1 in TRAMP mice leads to dramatic alterations in the circulating insulin-like growth factor axis but does not reduce tumor progression. Cancer Research. 68: 3342-9. PMID 18451161 DOI: 10.1158/0008-5472.Can-07-3165 |
0.376 |
|
| 2008 |
Novosyadlyy R, Kurshan N, Lann D, Vijayakumar A, Yakar S, LeRoith D. Insulin-like growth factor-I protects cells from ER stress-induced apoptosis via enhancement of the adaptive capacity of endoplasmic reticulum. Cell Death and Differentiation. 15: 1304-17. PMID 18437163 DOI: 10.1038/Cdd.2008.52 |
0.319 |
|
| 2008 |
Leroith D. Our evolving understanding of getting to goal using insulin in type 2 diabetes. Endocrinology and Metabolism Clinics of North America. 9-19. PMID 18407030 DOI: 10.1016/S0889-8529(07)80008-9 |
0.41 |
|
| 2008 |
LeRoith D. Treatment of diabetes: a clinical update on insulin trials. Clinical Cornerstone. 8: 21-9; discussion 30-. PMID 18357953 DOI: 10.1016/S1098-3597(09)60005-3 |
0.366 |
|
| 2008 |
LeRoith D. Clinical relevance of systemic and local IGF-I: lessons from animal models. Pediatric Endocrinology Reviews : Per. 739-43. PMID 18317445 |
0.357 |
|
| 2008 |
Zhang J, Wu Y, Zhang Y, Leroith D, Bernlohr DA, Chen X. The role of lipocalin 2 in the regulation of inflammation in adipocytes and macrophages. Molecular Endocrinology (Baltimore, Md.). 22: 1416-26. PMID 18292240 DOI: 10.1210/Me.2007-0420 |
0.412 |
|
| 2008 |
Leroith D, Accili D. Mechanisms of disease: using genetically altered mice to study concepts of type 2 diabetes. Nature Clinical Practice. Endocrinology & Metabolism. 4: 164-72. PMID 18212763 DOI: 10.1038/Ncpendmet0729 |
0.483 |
|
| 2008 |
Bentov I, Narla G, Schayek H, Akita K, Plymate SR, LeRoith D, Friedman SL, Werner H. Insulin-like growth factor-i regulates Kruppel-like factor-6 gene expression in a p53-dependent manner. Endocrinology. 149: 1890-7. PMID 18174288 DOI: 10.1210/En.2007-0844 |
0.447 |
|
| 2008 |
Liu J, Yakar S, LeRoith D. Conditional Knockout of Mouse Insulin-Like Growth Factor-1 Gene Using the Cre/loxP System Proceedings of the Society For Experimental Biology and Medicine. 223: 344-351. DOI: 10.1111/j.1525-1373.2000.22349.x |
0.347 |
|
| 2008 |
Novosyadlyy R, Kurshan N, Lann D, Vijayakumar A, Yakar S, LeRoith D. OR12,3 Insulin-like growth factor I protects cells from ER stress-induced apoptosis via enhancement of the adaptive capacity of endoplasmic reticulum Growth Hormone & Igf Research. 18: S24. DOI: 10.1016/S1096-6374(08)70077-7 |
0.392 |
|
| 2008 |
Wu Y, Sun H, Kawashima Y, Yakar S, LeRoith D. OR11,1 Liver-derived circulating IGF-I is sufficient to restore linear growth in an IGF-I null mouse Growth Hormone & Igf Research. 18: S21. DOI: 10.1016/S1096-6374(08)70069-8 |
0.402 |
|
| 2007 |
Lann D, LeRoith D. Insulin resistance as the underlying cause for the metabolic syndrome. The Medical Clinics of North America. 91: 1063-77, viii. PMID 17964909 DOI: 10.1016/J.Mcna.2007.06.012 |
0.377 |
|
| 2007 |
LeRoith D, Yakar S. Mechanisms of disease: metabolic effects of growth hormone and insulin-like growth factor 1. Nature Clinical Practice. Endocrinology & Metabolism. 3: 302-10. PMID 17315038 DOI: 10.1038/Ncpendmet0427 |
0.52 |
|
| 2007 |
Inagaki K, Tiulpakov A, Rubtsov P, Sverdlova P, Peterkova V, Yakar S, Terekhov S, LeRoith D. A familial insulin-like growth factor-I receptor mutant leads to short stature: clinical and biochemical characterization. The Journal of Clinical Endocrinology and Metabolism. 92: 1542-8. PMID 17264177 DOI: 10.1210/Jc.2006-2354 |
0.461 |
|
| 2006 |
Bromberg JS, LeRoith D. Diabetes cure--is the glass half full? The New England Journal of Medicine. 355: 1372-4. PMID 17005956 DOI: 10.1056/Nejme068183 |
0.314 |
|
| 2006 |
Yakar S, Nunez NP, Pennisi P, Brodt P, Sun H, Fallavollita L, Zhao H, Scavo L, Novosyadlyy R, Kurshan N, Stannard B, East-Palmer J, Smith NC, Perkins SN, Fuchs-Young R, ... ... LeRoith D, et al. Increased tumor growth in mice with diet-induced obesity: impact of ovarian hormones. Endocrinology. 147: 5826-34. PMID 16959846 DOI: 10.1210/En.2006-0311 |
0.304 |
|
| 2006 |
Samani AA, Yakar S, LeRoith D, Brodt P. The role of the IGF system in cancer growth and metastasis: overview and recent insights. Endocrine Reviews. 28: 20-47. PMID 16931767 DOI: 10.1210/Er.2006-0001 |
0.413 |
|
| 2006 |
Loladze AV, Stull MA, Rowzee AM, Demarco J, Lantry JH, Rosen CJ, Leroith D, Wagner KU, Hennighausen L, Wood TL. Epithelial-specific and stage-specific functions of insulin-like growth factor-I during postnatal mammary development. Endocrinology. 147: 5412-23. PMID 16901968 DOI: 10.1210/En.2006-0427 |
0.449 |
|
| 2006 |
Shukla V, Coumoul X, Cao L, Wang RH, Xiao C, Xu X, Andò S, Yakar S, Leroith D, Deng C. Absence of the full-length breast cancer-associated gene-1 leads to increased expression of insulin-like growth factor signaling axis members. Cancer Research. 66: 7151-7. PMID 16849561 DOI: 10.1158/0008-5472.Can-05-4570 |
0.424 |
|
| 2006 |
Kim H, Pennisi PA, Gavrilova O, Pack S, Jou W, Setser-Portas J, East-Palmer J, Tang Y, Manganiello VC, LeRoith D. Effect of adipocyte β 3-adrenergic receptor activation on the type 2 diabetic MKR mice American Journal of Physiology - Endocrinology and Metabolism. 290: E1227-E1236. PMID 16682489 DOI: 10.1152/Ajpendo.00344.2005 |
0.374 |
|
| 2006 |
Yakar S, Bouxsein ML, Canalis E, Sun H, Glatt V, Gundberg C, Cohen P, Hwang D, Boisclair Y, Leroith D, Rosen CJ. The ternary IGF complex influences postnatal bone acquisition and the skeletal response to intermittent parathyroid hormone. The Journal of Endocrinology. 189: 289-99. PMID 16648296 DOI: 10.1677/Joe.1.06657 |
0.332 |
|
| 2006 |
Sadagurski M, Yakar S, Weingarten G, Holzenberger M, Rhodes CJ, Breitkreutz D, Leroith D, Wertheimer E. Insulin-like growth factor 1 receptor signaling regulates skin development and inhibits skin keratinocyte differentiation. Molecular and Cellular Biology. 26: 2675-87. PMID 16537911 DOI: 10.1128/Mcb.26.7.2675-2687.2006 |
0.402 |
|
| 2006 |
Pennisi P, Gavrilova O, Setser-Portas J, Jou W, Santopietro S, Clemmons D, Yakar S, LeRoith D. Recombinant human insulin-like growth factor-I treatment inhibits gluconeogenesis in a transgenic mouse model of type 2 diabetes mellitus Endocrinology. 147: 2619-2630. PMID 16513827 DOI: 10.1210/En.2005-1556 |
0.483 |
|
| 2006 |
Kim CH, Pennisi P, Zhao H, Yakar S, Kaufman JB, Iganaki K, Shiloach J, Scherer PE, Quon MJ, LeRoith D. MKR mice are resistant to the metabolic actions of both insulin and adiponectin: discordance between insulin resistance and adiponectin responsiveness. American Journal of Physiology. Endocrinology and Metabolism. 291: E298-305. PMID 16507604 DOI: 10.1152/Ajpendo.00319.2005 |
0.428 |
|
| 2006 |
Yakar S, Sun H, Zhao H, Pennisi P, Toyoshima Y, Setser J, Stannard B, Scavo L, Leroith D. Metabolic effects of IGF-I deficiency: lessons from mouse models. Pediatric Endocrinology Reviews : Per. 3: 11-9. PMID 16369209 |
0.402 |
|
| 2006 |
Asghar Z, Yau D, Chan F, LeRoith D, Chan CB, Wheeler MB. Insulin resistance causes increased beta-cell mass but defective glucose-stimulated insulin secretion in a murine model of type 2 diabetes Diabetologia. 49: 90-99. PMID 16362284 DOI: 10.1007/S00125-005-0045-Y |
0.441 |
|
| 2006 |
Anzo M, Cobb L, Mehta H, Hwang D, Yakar S, LeRoith D, Cohen P. P-48 TUMOR-DRIVEN ACTIVATION OF THE CIRCULATING GH-IGF SYSTEM RESULTS IN INCREASED SERUM IGF-1 LEVELS OF HEPATIC ORIGIN IN THE TRAMP MOUSE MODEL OF PROSTATE CANCER Growth Hormone & Igf Research. 16: S48. DOI: 10.1016/S1096-6374(07)70335-0 |
0.349 |
|
| 2006 |
Anzo M, Hwang D, Yakar S, LeRoith D, Cohen P. P-47 DELETION OF THE HEPATIC IGF-1 GENE IN TRAMP MICE LEADS TO DRAMATIC ALTERATIONS IN THE CIRCULATING IGF AXIS BUT DOES NOT REDUCE TUMOR PROGRESSION Growth Hormone & Igf Research. 16: S33-S34. DOI: 10.1016/S1096-6374(07)70285-X |
0.364 |
|
| 2006 |
Yakar S, LeRoith D, Sun H, Brodt P. PL06 CIRCULATING IGF-I LEVELS AS A RISK FACTOR IN THE ACCELERATED TUMOR GROWTH IN OBESE MICE Growth Hormone & Igf Research. 16: S9. DOI: 10.1016/S1096-6374(07)70209-5 |
0.34 |
|
| 2006 |
LeRoith D. Endocrine Disorders During Pregnancy Endocrinology and Metabolism Clinics of North America. 35: xi-xii. DOI: 10.1016/J.Ecl.2005.11.001 |
0.32 |
|
| 2006 |
Asghar Z, Yau D, Chan F, LeRoith D, Chan CB, Wheeler MB. Insulin resistance causes increased beta-cell mass but defective glucose-stimulated insulin secretion in a murine model of type 2 diabetes Diabetologia. 49: 615-615. DOI: 10.1007/s00125-006-0157-z |
0.312 |
|
| 2005 |
Freedman RJ, Malkovska V, LeRoith D, Collins MT. Hodgkin lymphoma in temporal association with growth hormone replacement Endocrine Journal. 52: 571-575. PMID 16284435 DOI: 10.1507/Endocrj.52.571 |
0.305 |
|
| 2005 |
Barbour LA, Mizanoor Rahman S, Gurevich I, Leitner JW, Fischer SJ, Roper MD, Knotts TA, Vo Y, McCurdy CE, Yakar S, Leroith D, Kahn CR, Cantley LC, Friedman JE, Draznin B. Increased P85alpha is a potent negative regulator of skeletal muscle insulin signaling and induces in vivo insulin resistance associated with growth hormone excess. The Journal of Biological Chemistry. 280: 37489-94. PMID 16166093 DOI: 10.1074/Jbc.M506967200 |
0.476 |
|
| 2005 |
LeRoith D, Gavrilova O. Mouse models created to study the pathophysiology of Type 2 diabetes. The International Journal of Biochemistry & Cell Biology. 38: 904-12. PMID 16103004 DOI: 10.1016/J.Biocel.2005.01.019 |
0.36 |
|
| 2005 |
Toyoshima Y, Gavrilova O, Yakar S, Jou W, Pack S, Asghar Z, Wheeler M, LeRoith D. Leptin improves insulin resistance and hyperglycemia in a mouse model of type 2 diabetes Endocrinology. 146: 4024-4035. PMID 15947005 DOI: 10.1210/En.2005-0087 |
0.395 |
|
| 2005 |
Yakar S, Leroith D, Brodt P. The role of the growth hormone/insulin-like growth factor axis in tumor growth and progression: Lessons from animal models. Cytokine & Growth Factor Reviews. 16: 407-20. PMID 15886048 DOI: 10.1016/J.Cytogfr.2005.01.010 |
0.473 |
|
| 2005 |
Yakar S, Pennisi P, Wu Y, Zhao H, LeRoith D. Clinical relevance of systemic and local IGF-I. Endocrine Development. 9: 11-16. PMID 15879684 DOI: 10.1159/000085718 |
0.481 |
|
| 2005 |
Leroith D, Nissley P. Knock your SOCS off! The Journal of Clinical Investigation. 115: 233-6. PMID 15690080 DOI: 10.1172/Jci24228 |
0.359 |
|
| 2005 |
Yakar S, Kim H, Zhao H, Toyoshima Y, Pennisi P, Gavrilova O, Leroith D. The growth hormone-insulin like growth factor axis revisited: lessons from IGF-1 and IGF-1 receptor gene targeting. Pediatric Nephrology (Berlin, Germany). 20: 251-4. PMID 15645308 DOI: 10.1007/S00467-004-1613-Y |
0.514 |
|
| 2005 |
Kim H, Barton E, Muja N, Yakar S, Pennisi P, Leroith D. Intact insulin and insulin-like growth factor-I receptor signaling is required for growth hormone effects on skeletal muscle growth and function in vivo. Endocrinology. 146: 1772-9. PMID 15618350 DOI: 10.1210/En.2004-0906 |
0.426 |
|
| 2004 |
Kim H, Haluzik M, Gavrilova O, Yakar S, Portas J, Sun H, Pajvani UB, Scherer PE, LeRoith D. Thiazolidinediones improve insulin sensitivity in adipose tissue and reduce the hyperlipidaemia without affecting the hyperglycaemia in a transgenic model of type 2 diabetes. Diabetologia. 47: 2215-25. PMID 15662559 DOI: 10.1007/S00125-004-1581-6 |
0.364 |
|
| 2004 |
Smith DO, LeRoith D. Insulin resistance syndrome, pre-diabetes, and the prevention of type 2 diabetes mellitus. Clinical Cornerstone. 6: 7-6. PMID 15628689 DOI: 10.1016/S1098-3597(04)80050-4 |
0.358 |
|
| 2004 |
Lu Y, Herrera PL, Guo Y, Sun D, Tang Z, LeRoith D, Liu JL. Pancreatic-specific inactivation of IGF-I gene causes enlarged pancreatic islets and significant resistance to diabetes. Diabetes. 53: 3131-41. PMID 15561943 DOI: 10.2337/Diabetes.53.12.3131 |
0.471 |
|
| 2004 |
Zhao H, Yakar S, Gavrilova O, Sun H, Zhang Y, Kim H, Setser J, Jou W, LeRoith D. Phloridzin improves hyperglycemia but not hepatic insulin resistance in a transgenic mouse model of type 2 diabetes Diabetes. 53: 2901-2909. PMID 15504971 DOI: 10.2337/Diabetes.53.11.2901 |
0.429 |
|
| 2004 |
Liu YF, Herschkovitz A, Boura-Halfon S, Ronen D, Paz K, Leroith D, Zick Y. Serine phosphorylation proximal to its phosphotyrosine binding domain inhibits insulin receptor substrate 1 function and promotes insulin resistance. Molecular and Cellular Biology. 24: 9668-81. PMID 15485932 DOI: 10.1128/Mcb.24.21.9668-9681.2004 |
0.453 |
|
| 2004 |
Rose A, Froment P, Perrot V, Quon MJ, LeRoith D, Dupont J. The luteinizing hormone-releasing hormone inhibits the anti-apoptotic activity of insulin-like growth factor-1 in pituitary alphaT3 cells by protein kinase Calpha-mediated negative regulation of Akt. The Journal of Biological Chemistry. 279: 52500-16. PMID 15448167 DOI: 10.1074/Jbc.M404571200 |
0.452 |
|
| 2004 |
Scavo LM, Karas M, Murray M, Leroith D. Insulin-like growth factor-I stimulates both cell growth and lipogenesis during differentiation of human mesenchymal stem cells into adipocytes. The Journal of Clinical Endocrinology and Metabolism. 89: 3543-53. PMID 15240644 DOI: 10.1210/Jc.2003-031682 |
0.457 |
|
| 2004 |
LeRoith D. Editorial: A blast from the past--insulin does it again! The Journal of Clinical Endocrinology and Metabolism. 89: 3103-4. PMID 15240577 DOI: 10.1210/Jc.2004-0740 |
0.452 |
|
| 2004 |
Héron-Milhavet L, Haluzik M, Yakar S, Gavrilova O, Pack S, Jou WC, Ibrahimi A, Kim H, Hunt D, Yau D, Asghar Z, Joseph J, Wheeler MB, Abumrad NA, LeRoith D. Muscle-specific overexpression of CD36 reverses the insulin resistance and diabetes of MKR mice Endocrinology. 145: 4667-4676. PMID 15231693 DOI: 10.1210/En.2003-1543 |
0.403 |
|
| 2004 |
Zhang Y, Karas M, Zhao H, Yakar S, LeRoith D. 14-3-3sigma mediation of cell cycle progression is p53-independent in response to insulin-like growth factor-I receptor activation. The Journal of Biological Chemistry. 279: 34353-60. PMID 15187095 DOI: 10.1074/Jbc.M401300200 |
0.469 |
|
| 2004 |
LeRoith D, Helman L. The new kid on the block(ade) of the IGF-1 receptor. Cancer Cell. 5: 201-2. PMID 15050909 DOI: 10.1016/S1535-6108(04)00054-6 |
0.455 |
|
| 2004 |
Toyoshima Y, Karas M, Yakar S, Dupont J, LeRoith D. TDAG51 mediates the effects of insulin-like growth factor I (IGF-I) on cell survival. The Journal of Biological Chemistry. 279: 25898-904. PMID 15037619 DOI: 10.1074/Jbc.M400661200 |
0.492 |
|
| 2004 |
Welniak LA, Karas M, Yakar S, Anver MR, Murphy WJ, LeRoith D. Effects of organ-specific loss of insulin-like growth factor-I production on murine hematopoiesis. Biology of Blood and Marrow Transplantation : Journal of the American Society For Blood and Marrow Transplantation. 10: 32-9. PMID 14752777 DOI: 10.1016/J.Bbmt.2003.09.008 |
0.379 |
|
| 2004 |
Zhao H, Dupont J, Yakar S, Karas M, LeRoith D. PTEN inhibits cell proliferation and induces apoptosis by downregulating cell surface IGF-IR expression in prostate cancer cells. Oncogene. 23: 786-94. PMID 14737113 DOI: 10.1038/Sj.Onc.1207162 |
0.395 |
|
| 2004 |
Inoue H, Ogawa W, Ozaki M, Haga S, Matsumoto M, Furukawa K, Hashimoto N, Kido Y, Mori T, Sakaue H, Teshigawara K, Jin S, Iguchi H, Hiramatsu R, LeRoith D, et al. Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo. Nature Medicine. 10: 168-74. PMID 14716305 DOI: 10.1038/Nm980 |
0.364 |
|
| 2004 |
Yakar S, Setser J, Zhao H, Stannard B, Haluzik M, Glatt V, Bouxsein ML, Kopchick JJ, LeRoith D. Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1-deficient mice. The Journal of Clinical Investigation. 113: 96-105. PMID 14702113 DOI: 10.1172/Jci200417763 |
0.473 |
|
| 2004 |
Mejia-Naranjo W, Yakar S, Bernal R, LeRoith D, Sanchez-Gomez M. Regulation of the splenic somatotropic axis by dietary protein and insulin-like growth factor-I in the rat. Growth Hormone & Igf Research : Official Journal of the Growth Hormone Research Society and the International Igf Research Society. 13: 254-63. PMID 12932746 DOI: 10.1016/S1096-6374(03)00014-5 |
0.43 |
|
| 2004 |
Chu Y, Yakar S, LeRoith D, Gress R. Insulin-Like Growth Factor I Is a Positive Regulator of Thymic Function. Blood. 104: 732-732. DOI: 10.1182/Blood.V104.11.732.732 |
0.348 |
|
| 2004 |
Yakar S, Setser J, Zhao H, Stannard B, Haluzik M, Glatt V, Bouxsein ML, Kopchick JJ, LeRoith D. Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1–deficient mice Journal of Clinical Investigation. 113: 96-105. DOI: 10.1172/JCI200417763 |
0.349 |
|
| 2004 |
LeRoith D, Helman L. The new kid on the block(ade) of the IGF-1 receptor Cancer Cell. 5: 403. DOI: 10.1016/S1535-6108(04)00093-5 |
0.33 |
|
| 2004 |
Yakar S, Pennisi P, Zhao H, Zhang Y, LeRoith D. Circulating IGF-1 and its role in cancer: lessons from the IGF-1 gene deletion (LID) mouse. Novartis Foundation Symposium. 262: 3-18. DOI: 10.1002/0470869976.Ch2 |
0.402 |
|
| 2003 |
Haluzik M, Gavrilova O, LeRoith D. Peroxisome proliferator-activated receptor-alpha deficiency does not alter insulin sensitivity in mice maintained on regular or high-fat diet: hyperinsulinemic-euglycemic clamp studies. Endocrinology. 145: 1662-7. PMID 14670996 DOI: 10.1210/En.2003-1015 |
0.389 |
|
| 2003 |
Haluzik M, Yakar S, Gavrilova O, Setser J, Boisclair Y, LeRoith D. Insulin resistance in the liver-specific IGF-1 gene-deleted mouse is abrogated by deletion of the acid-labile subunit of the IGF-binding protein-3 complex: relative roles of growth hormone and IGF-1 in insulin resistance. Diabetes. 52: 2483-9. PMID 14514630 DOI: 10.2337/Diabetes.52.10.2483 |
0.495 |
|
| 2003 |
Bentov I, LeRoith D, Werner H. The WT1 Wilms' tumor suppressor gene: a novel target for insulin-like growth factor-I action. Endocrinology. 144: 4276-9. PMID 12960088 DOI: 10.1210/En.2003-0400 |
0.463 |
|
| 2003 |
Dupont J, Karas M, LeRoith D. The cyclin-dependent kinase inhibitor p21CIP/WAF is a positive regulator of insulin-like growth factor I-induced cell proliferation in MCF-7 human breast cancer cells. The Journal of Biological Chemistry. 278: 37256-64. PMID 12867429 DOI: 10.1074/Jbc.M302355200 |
0.437 |
|
| 2003 |
Yu R, Yakar S, Liu YL, Lu Y, LeRoith D, Miao D, Liu JL. Liver-specific IGF-I gene deficient mice exhibit accelerated diabetes in response to streptozotocin, associated with early onset of insulin resistance. Molecular and Cellular Endocrinology. 204: 31-42. PMID 12850279 DOI: 10.1016/S0303-7207(03)00145-X |
0.426 |
|
| 2003 |
Kim H, Haluzik M, Asghar Z, Yau D, Joseph JW, Fernandez AM, Reitman ML, Yakar S, Stannard B, Heron-Milhavet L, Wheeler MB, LeRoith D. Peroxisome proliferator-activated receptor-alpha agonist treatment in a transgenic model of type 2 diabetes reverses the lipotoxic state and improves glucose homeostasis. Diabetes. 52: 1770-8. PMID 12829645 DOI: 10.2337/Diabetes.52.7.1770 |
0.443 |
|
| 2003 |
Dupont J, Dunn SE, Barrett JC, LeRoith D. Microarray analysis and identification of novel molecules involved in insulin-like growth factor-1 receptor signaling and gene expression. Recent Progress in Hormone Research. 58: 325-42. PMID 12795426 DOI: 10.1210/rp.58.1.325 |
0.419 |
|
| 2003 |
LeRoith D, Roberts CT. The insulin-like growth factor system and cancer. Cancer Letters. 195: 127-37. PMID 12767520 DOI: 10.1016/S0304-3835(03)00159-9 |
0.465 |
|
| 2002 |
LeRoith D. Beta-cell dysfunction and insulin resistance in type 2 diabetes: role of metabolic and genetic abnormalities. The American Journal of Medicine. 3S-11S. PMID 12431757 DOI: 10.1016/S0002-9343(02)01276-7 |
0.413 |
|
| 2002 |
Akintoye SO, Chebli C, Booher S, Feuillan P, Kushner H, Leroith D, Cherman N, Bianco P, Wientroub S, Robey PG, Collins MT. Characterization of gsp-mediated growth hormone excess in the context of McCune-Albright syndrome Journal of Clinical Endocrinology and Metabolism. 87: 5104-5112. PMID 12414879 DOI: 10.1210/Jc.2001-012022 |
0.352 |
|
| 2002 |
Dupont J, Renou JP, Shani M, Hennighausen L, LeRoith D. PTEN overexpression suppresses proliferation and differentiation and enhances apoptosis of the mouse mammary epithelium Journal of Clinical Investigation. 110: 815-825. PMID 12235113 DOI: 10.1172/Jci13829 |
0.349 |
|
| 2002 |
Yakar S, Rosen CJ, Beamer WG, Ackert-Bicknell CL, Wu Y, Liu JL, Ooi GT, Setser J, Frystyk J, Boisclair YR, LeRoith D. Circulating levels of IGF-1 directly regulate bone growth and density. The Journal of Clinical Investigation. 110: 771-81. PMID 12235108 DOI: 10.1172/Jci15463 |
0.404 |
|
| 2002 |
Naranjo WM, Yakar S, Sanchez-Gomez M, Perez AU, Setser J, LERoith D. Protein calorie restriction affects nonhepatic IGF-I production and the lymphoid system: studies using the liver-specific IGF-I gene-deleted mouse model. Endocrinology. 143: 2233-41. PMID 12021187 DOI: 10.1210/Endo.143.6.8852 |
0.448 |
|
| 2002 |
Butler AA, Yakar S, LeRoith D. Insulin-like growth factor-I: compartmentalization within the somatotropic axis? News in Physiological Sciences : An International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society. 17: 82-5. PMID 11909998 DOI: 10.1152/Nips.01351.2001 |
0.468 |
|
| 2002 |
Héron-Milhavet L, LeRoith D. Insulin-like growth factor I induces MDM2-dependent degradation of p53 via the p38 MAPK pathway in response to DNA damage. The Journal of Biological Chemistry. 277: 15600-6. PMID 11877395 DOI: 10.1074/Jbc.M111142200 |
0.362 |
|
| 2002 |
Burroughs KD, Howe SR, Okubo Y, Fuchs-Young R, LeRoith D, Walker CL. Dysregulation of IGH-I signaling in uterine leiomyoma Journal of Endocrinology. 172: 83-93. PMID 11786376 DOI: 10.1677/Joe.0.1720083 |
0.471 |
|
| 2002 |
Dupont J, LeRoith D. Insulin and insulin-like growth factor I receptors: similarities and differences in signal transduction. Hormone Research. 22-6. PMID 11684871 DOI: 10.1159/000063469 |
0.481 |
|
| 2001 |
Dupont J, Khan J, Qu BH, Metzler P, Helman L, LeRoith D. Insulin and IGF-1 induce different patterns of gene expression in mouse fibroblast NIH-3T3 cells: identification by cDNA microarray analysis. Endocrinology. 142: 4969-75. PMID 11606465 DOI: 10.1210/Endo.142.11.8476 |
0.512 |
|
| 2001 |
Jacobs AR, LeRoith D, Taylor SI. Insulin receptor substrate-1 pleckstrin homology and phosphotyrosine-binding domains are both involved in plasma membrane targeting. The Journal of Biological Chemistry. 276: 40795-802. PMID 11526109 DOI: 10.1074/Jbc.M105194200 |
0.4 |
|
| 2001 |
Hellstrom A, Perruzzi C, Ju M, Engstrom E, Hard AL, Liu JL, Albertsson-Wikland K, Carlsson B, Niklasson A, Sjodell L, LeRoith D, Senger DR, Smith LE. Low IGF-I suppresses VEGF-survival signaling in retinal endothelial cells: direct correlation with clinical retinopathy of prematurity. Proceedings of the National Academy of Sciences of the United States of America. 98: 5804-8. PMID 11331770 DOI: 10.1073/Pnas.101113998 |
0.346 |
|
| 2001 |
Dupont J, Fernandez AM, Glackin CA, Helman L, LeRoith D. Insulin-like growth factor 1 (IGF-1)-induced twist expression is involved in the anti-apoptotic effects of the IGF-1 receptor. The Journal of Biological Chemistry. 276: 26699-707. PMID 11323435 DOI: 10.1074/Jbc.M102664200 |
0.511 |
|
| 2001 |
Karas M, Koval AP, Zick Y, LeRoith D. The insulin-like growth factor I receptor-induced interaction of insulin receptor substrate-4 and Crk-II Endocrinology. 142: 1835-1840. PMID 11316748 DOI: 10.1210/Endo.142.5.8135 |
0.459 |
|
| 2001 |
Butler AA, LeRoith D. Minireview: tissue-specific versus generalized gene targeting of the igf1 and igf1r genes and their roles in insulin-like growth factor physiology. Endocrinology. 142: 1685-8. PMID 11316729 DOI: 10.1210/Endo.142.5.8148 |
0.484 |
|
| 2001 |
Héron-Milhavet L, Karas M, Goldsmith CM, Baum BJ, LeRoith D. Insulin-like growth factor-I (IGF-I) receptor activation rescues UV-damaged cells through a p38 signaling pathway. Potential role of the IGF-I receptor in DNA repair. The Journal of Biological Chemistry. 276: 18185-92. PMID 11278917 DOI: 10.1074/Jbc.M011490200 |
0.421 |
|
| 2001 |
Liu YF, Paz K, Herschkovitz A, Alt A, Tennenbaum T, Sampson SR, Ohba M, Kuroki T, LeRoith D, Zick Y. Insulin stimulates PKCζ-mediated phosphorylation of insulin receptor substrate-1 (IRS-1). A self-attenuated mechanism to negatively regulate the function of IRS proteins Journal of Biological Chemistry. 276: 14459-14465. PMID 11278339 DOI: 10.1074/Jbc.M007281200 |
0.466 |
|
| 2000 |
LeRoith D. Editorial: Insulin-Like Growth Factor I Receptor Signaling-Overlapping or Redundant Pathways? Endocrinology. 141: 1287-1288. PMID 28200980 DOI: 10.1210/Endo.141.4.7475 |
0.466 |
|
| 2000 |
Liu JL, Yakar S, LeRoith D. Mice deficient in liver production of insulin-like growth factor I display sexual dimorphism in growth hormone-stimulated postnatal growth. Endocrinology. 141: 4436-41. PMID 11108252 DOI: 10.1210/Endo.141.12.7825 |
0.406 |
|
| 2000 |
Landau D, Domene H, Flyvbjerg A, Grønbaek H, Roberts CT, Argov S, LeRoith D. Differential expression of renal growth hormone receptor and its binding protein in experimental diabetes mellitus. Growth Hormone & Igf Research : Official Journal of the Growth Hormone Research Society and the International Igf Research Society. 8: 39-45. PMID 10990443 DOI: 10.1016/S1096-6374(98)80320-1 |
0.348 |
|
| 2000 |
Burvin R, LeRoith D, Harel H, Zloczower M, Marbach M, Karnieli E. The effect of acute insulin-like growth factor-II administration on glucose metabolism in the rat. Growth Hormone & Igf Research : Official Journal of the Growth Hormone Research Society and the International Igf Research Society. 8: 205-10. PMID 10984308 DOI: 10.1016/S1096-6374(98)80112-3 |
0.463 |
|
| 2000 |
Dupont J, Karas M, LeRoith D. The potentiation of estrogen on insulin-like growth factor I action in MCF-7 human breast cancer cells includes cell cycle components. The Journal of Biological Chemistry. 275: 35893-901. PMID 10967123 DOI: 10.1074/Jbc.M006741200 |
0.413 |
|
| 2000 |
Foncea R, Gálvez A, Pérez V, Morales MP, Calixto A, Meléndez J, González-Jara F, Díaz-Araya G, Sapag-Hagar M, Sugden PH, LeRoith D, Lavandero S. Extracellular regulated kinase, but not protein kinase C, is an antiapoptotic signal of insulin-like growth factor-1 on cultured cardiac myocytes. Biochemical and Biophysical Research Communications. 273: 736-44. PMID 10873673 DOI: 10.1006/Bbrc.2000.3008 |
0.409 |
|
| 2000 |
Kato H, Okubo Y, Matsumura Y, Roberts CT, Sugahara K, LeRoith D. The tyrosine kinase activity of the chicken insulin receptor is similar to that of the human insulin receptor. Bioscience, Biotechnology, and Biochemistry. 64: 903-6. PMID 10830518 DOI: 10.1271/Bbb.64.903 |
0.455 |
|
| 2000 |
Paz K, Boura-Halfon S, Wyatt LS, LeRoith D, Zick Y. The juxtamembrane but not the carboxyl-terminal domain of the insulin receptor mediates insulin's metabolic functions in primary adipocytes and cultured hepatoma cells Journal of Molecular Endocrinology. 24: 419-432. PMID 10828835 DOI: 10.1677/Jme.0.0240419 |
0.369 |
|
| 2000 |
Goh EL, Zhu T, Yakar S, LeRoith D, Lobie PE. CrkII participation in the cellular effects of growth hormone and insulin-like growth factor-1. Phosphatidylinositol-3 kinase dependent and independent effects. The Journal of Biological Chemistry. 275: 17683-92. PMID 10748058 DOI: 10.1074/Jbc.M001972200 |
0.352 |
|
| 2000 |
Liu JL, Yakar S, LeRoith D. Conditional knockout of mouse insulin-like growth factor-1 gene using the Cre/loxP system. Proceedings of the Society For Experimental Biology and Medicine. Society For Experimental Biology and Medicine (New York, N.Y.). 223: 344-51. PMID 10721003 DOI: 10.1046/J.1525-1373.2000.22349.X |
0.464 |
|
| 2000 |
de Lacerda L, Carvalho JA, Stannard B, Werner H, Boguszewski MC, Sandrini R, Malozowski SN, Leroith D, Underwood LE. In vitro and in vivo responses to short-term recombinant human insulin-like growth factor-1 (IGF-I) in a severely growth-retarded girl with ring chromosome 15 and deletion of a single allele for the type 1 IGF receptor gene. Clinical Endocrinology. 51: 541-50. PMID 10594514 DOI: 10.1046/J.1365-2265.1999.00799.X |
0.434 |
|
| 2000 |
Wallenius K, Sjögren K, Liu J, Leroith D, Isaksson O, Ohlsson C, Jansson J. Liver-derived insulin-like growth factor I is aregulator of the growth hormone secretion pattern in mice Growth Hormone & Igf Research. 10: S168. DOI: 10.1016/S1096-6374(00)80063-5 |
0.442 |
|
| 1999 |
Liu JL, LeRoith D. Insulin-like growth factor I is essential for postnatal growth in response to growth hormone. Endocrinology. 140: 5178-84. PMID 10537147 DOI: 10.1210/Endo.140.11.7151 |
0.427 |
|
| 1999 |
Qu BH, Karas M, Koval A, LeRoith D. Insulin receptor substrate-4 enhances insulin-like growth factor-I-induced cell proliferation. The Journal of Biological Chemistry. 274: 31179-84. PMID 10531310 DOI: 10.1074/Jbc.274.44.31179 |
0.491 |
|
| 1999 |
Paz K, Liu YF, Shorer H, Hemi R, LeRoith D, Quan M, Kanety H, Seger R, Zick Y. Phosphorylation of insulin receptor substrate-1 (IRS-1) by protein kinase B positively regulates IRS-1 function Journal of Biological Chemistry. 274: 28816-28822. PMID 10497255 DOI: 10.1074/Jbc.274.40.28816 |
0.411 |
|
| 1999 |
Yakar S, Liu JL, Stannard B, Butler A, Accili D, Sauer B, LeRoith D. Normal growth and development in the absence of hepatic insulin-like growth factor I. Proceedings of the National Academy of Sciences of the United States of America. 96: 7324-9. PMID 10377413 DOI: 10.1073/Pnas.96.13.7324 |
0.474 |
|
| 1999 |
Hernández-Sánchez C, Ito Y, Ferrer J, Reitman M, LeRoith D. Characterization of the mouse sulfonylurea receptor 1 promoter and its regulation. The Journal of Biological Chemistry. 274: 18261-70. PMID 10373428 DOI: 10.1074/Jbc.274.26.18261 |
0.322 |
|
| 1999 |
Sjögren K, Liu JL, Blad K, Skrtic S, Vidal O, Wallenius V, LeRoith D, Törnell J, Isaksson OG, Jansson JO, Ohlsson C. Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice. Proceedings of the National Academy of Sciences of the United States of America. 96: 7088-92. PMID 10359843 DOI: 10.1073/Pnas.96.12.7088 |
0.419 |
|
| 1998 |
Butler AA, Yakar S, Gewolb IH, Karas M, Okubo Y, LeRoith D. Insulin-like growth factor-I receptor signal transduction: at the interface between physiology and cell biology. Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology. 121: 19-26. PMID 9972281 DOI: 10.1016/S0305-0491(98)10106-2 |
0.5 |
|
| 1998 |
Liu JL, Grinberg A, Westphal H, Sauer B, Accili D, Karas M, LeRoith D. Insulin-like growth factor-I affects perinatal lethality and postnatal development in a gene dosage-dependent manner: manipulation using the Cre/loxP system in transgenic mice. Molecular Endocrinology (Baltimore, Md.). 12: 1452-62. PMID 9731712 DOI: 10.1210/Mend.12.9.0162 |
0.422 |
|
| 1998 |
Blakesley VA, Koval AP, Stannard BS, Scrimgeour A, LeRoith D. Replacement of tyrosine 1251 in the carboxyl terminus of the insulin-like growth factor-I receptor disrupts the actin cytoskeleton and inhibits proliferation and anchorage-independent growth. The Journal of Biological Chemistry. 273: 18411-22. PMID 9660809 DOI: 10.1074/Jbc.273.29.18411 |
0.464 |
|
| 1998 |
Koval AP, Karas M, Zick Y, LeRoith D. Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth factor-I receptor-mediated signal transduction Journal of Biological Chemistry. 273: 14780-14787. PMID 9614078 DOI: 10.1074/Jbc.273.24.14780 |
0.419 |
|
| 1998 |
Kalebic T, Blakesley V, Slade C, Plasschaert S, Leroith D, Helman LJ. Expression of a kinase-deficient IGF-I-R suppresses tumorigenicity of rhabdomyosarcoma cells constitutively expressing a wild type IGF-I-R. International Journal of Cancer. 76: 223-7. PMID 9537584 DOI: 10.1002/(Sici)1097-0215(19980413)76:2<223::Aid-Ijc9>3.0.Co;2-Z |
0.411 |
|
| 1998 |
Ohlsson C, Kley N, Werner H, LeRoith D. p53 regulates insulin-like growth factor-I (IGF-I) receptor expression and IGF-I-induced tyrosine phosphorylation in an osteosarcoma cell line: interaction between p53 and Sp1. Endocrinology. 139: 1101-7. PMID 9492043 DOI: 10.1210/Endo.139.3.5832 |
0.438 |
|
| 1998 |
Koval AP, Blakesley VA, Roberts CT, Zick Y, LeRoith D. Interaction in vitro of the product of the c-Crk-II proto-oncogene with the insulin-like growth factor I receptor Biochemical Journal. 330: 923-932. PMID 9480911 DOI: 10.1042/Bj3300923 |
0.399 |
|
| 1998 |
Li SL, Termini J, Hayward A, Siddle K, Zick Y, Koval A, Leroith D, Fujita-Yamaguchi Y. The carboxyl-terminal domain of insulin-like growth factor-I receptor interacts with the insulin receptor and activates its protein tyrosine kinase Febs Letters. 421: 45-49. PMID 9462837 DOI: 10.1016/S0014-5793(97)01523-8 |
0.428 |
|
| 1997 |
Pa Rrizas M, LeRoith D. Insulin-Like Growth Factor-1 Inhibition of Apoptosis Is Associated with Increased Expression of the bcl-xL Gene Product. Endocrinology. 138: 1355-1358. PMID 28200255 DOI: 10.1210/Endo.138.3.5103 |
0.4 |
|
| 1997 |
Pa Rrizas M, Gazit A, Levitzki A, Wertheimer E, LeRoith D. Specific Inhibition of Insulin-Like Growth Factor-1 and Insulin Receptor Tyrosine Kinase Activity and Biological Function by Tyrphostins. Endocrinology. 138: 1427-1433. PMID 28200205 DOI: 10.1210/Endo.138.4.5092 |
0.453 |
|
| 1997 |
Jaffa AA, Vio C, Velarde V, LeRoith D, Mayfield RK. Induction of renal kallikrein and renin gene expression by insulin and IGF-I in the diabetic rat. Diabetes. 46: 2049-56. PMID 9392495 DOI: 10.2337/Diab.46.12.2049 |
0.401 |
|
| 1997 |
Toretsky JA, Kalebic T, Blakesley V, LeRoith D, Helman LJ. The insulin-like growth factor-I receptor is required for EWS/FLI-1 transformation of fibroblasts Journal of Biological Chemistry. 272: 30822-30827. PMID 9388225 DOI: 10.1074/Jbc.272.49.30822 |
0.46 |
|
| 1997 |
Paz K, Hemi R, LeRoith D, Karasik A, Elhanany E, Kanety H, Zick Y. A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation Journal of Biological Chemistry. 272: 29911-29918. PMID 9368067 DOI: 10.1074/Jbc.272.47.29911 |
0.367 |
|
| 1997 |
Liu JL, Blakesley VA, Gutkind JS, LeRoith D. The constitutively active mutant Galpha13 transforms mouse fibroblast cells deficient in insulin-like growth factor-I receptor. The Journal of Biological Chemistry. 272: 29438-41. PMID 9368001 DOI: 10.1074/Jbc.272.47.29438 |
0.421 |
|
| 1997 |
Butler AA, Blakesley VA, Koval A, deJong R, Groffen J, LeRoith D. In vivo regulation of CrkII and CrkL proto-oncogenes in the uterus by insulin-like growth factor-I. Differential effects on tyrosine phosphorylation and association with paxillin. The Journal of Biological Chemistry. 272: 27660-4. PMID 9346905 DOI: 10.1074/jbc.272.44.27660 |
0.404 |
|
| 1997 |
Ng ST, Zhou J, Adesanya OO, Wang J, LeRoith D, Bondy CA. Growth hormone treatment induces mammary gland hyperplasia in aging primates. Nature Medicine. 3: 1141-4. PMID 9334728 DOI: 10.1038/Nm1097-1141 |
0.442 |
|
| 1997 |
Wang J, Niu W, Nikiforov Y, Naito S, Chernausek S, Witte D, LeRoith D, Strauch A, Fagin JA. Targeted overexpression of IGF-I evokes distinct patterns of organ remodeling in smooth muscle cell tissue beds of transgenic mice. The Journal of Clinical Investigation. 100: 1425-39. PMID 9294108 DOI: 10.1172/Jci119663 |
0.402 |
|
| 1997 |
Foncea R, Andersson M, Ketterman A, Blakesley V, Sapag-Hagar M, Sugden PH, LeRoith D, Lavandero S. Insulin-like growth factor-I rapidly activates multiple signal transduction pathways in cultured rat cardiac myocytes. The Journal of Biological Chemistry. 272: 19115-24. PMID 9235900 DOI: 10.1074/jbc.272.31.19115 |
0.321 |
|
| 1997 |
Esposito DL, Blakesley VA, Koval AP, Scrimgeour AG, LeRoith D. Tyrosine residues in the C-terminal domain of the insulin-like growth factor-I receptor mediate mitogenic and tumorigenic signals. Endocrinology. 138: 2979-88. PMID 9202243 DOI: 10.1210/Endo.138.7.5281 |
0.475 |
|
| 1997 |
Karas M, Danilenko M, Fishman D, LeRoith D, Levy J, Sharoni Y. Membrane-associated insulin-like growth factor-binding protein-3 inhibits insulin-like growth factor-I-induced insulin-like growth factor-I receptor signaling in ishikawa endometrial cancer cells. The Journal of Biological Chemistry. 272: 16514-20. PMID 9195961 DOI: 10.1074/jbc.272.26.16514 |
0.405 |
|
| 1997 |
Najjar SM, Blakesley VA, Li Calzi S, Kato H, LeRoith D, Choice CV. Differential phosphorylation of pp120 by insulin and insulin-like growth factor-1 receptors: role for the C-terminal domain of the beta-subunit. Biochemistry. 36: 6827-34. PMID 9184166 DOI: 10.1021/Bi962634H |
0.49 |
|
| 1997 |
Scrimgeour AG, Blakesley VA, Stannard BS, LeRoith D. Mitogen-activated protein kinase and phosphatidylinositol 3-kinase pathways are not sufficient for insulin-like growth factor I-induced mitogenesis and tumorigenesis. Endocrinology. 138: 2552-8. PMID 9165048 DOI: 10.1210/Endo.138.6.5215 |
0.39 |
|
| 1997 |
Sass DA, Jerome CP, Bowman AR, Bennett-Cain A, Ginn TA, LeRoith D, Epstein S. Short-term effects of growth hormone and insulin-like growth factor I on cancellous bone in rhesus macaque monkeys. The Journal of Clinical Endocrinology and Metabolism. 82: 1202-9. PMID 9100597 DOI: 10.1210/Jcem.82.4.3903 |
0.355 |
|
| 1997 |
Blakesley VA, Stannard BS, Kalebic T, Helman LJ, LeRoith D. Role of the IGF-I receptor in mutagenesis and tumor promotion. The Journal of Endocrinology. 152: 339-44. PMID 9071953 DOI: 10.1677/Joe.0.1520339 |
0.363 |
|
| 1997 |
Chin E, Zamah AM, Landau D, Grønbcek H, Flyvbjerg A, LeRoith D, Bondy CA. Changes in facilitative glucose transporter messenger ribonucleic acid levels in the diabetic rat kidney. Endocrinology. 138: 1267-75. PMID 9048635 DOI: 10.1210/Endo.138.3.5015 |
0.313 |
|
| 1997 |
Hernández-Sánchez C, Werner H, Roberts CT, Woo EJ, Hum DW, Rosenthal SM, LeRoith D. Differential regulation of insulin-like growth factor-I (IGF-I) receptor gene expression by IGF-I and basic fibroblastic growth factor. The Journal of Biological Chemistry. 272: 4663-70. PMID 9030517 DOI: 10.1074/Jbc.272.8.4663 |
0.496 |
|
| 1997 |
Hernández-Sánchez C, Wood TL, Leroith D. Developmental and tissue-specific sulfonylurea receptor gene expression Endocrinology. 138: 705-711. PMID 9003005 DOI: 10.1210/Endo.138.2.4954 |
0.312 |
|
| 1997 |
Párrizas M, Saltiel AR, LeRoith D. Insulin-like growth factor 1 inhibits apoptosis using the phosphatidylinositol 3'-kinase and mitogen-activated protein kinase pathways Journal of Biological Chemistry. 272: 154-161. PMID 8995241 DOI: 10.1074/Jbc.272.1.154 |
0.374 |
|
| 1997 |
Domené HM, Landau D, Chin T, Flyvbjerg A, Leroith D. Growth Hormone-Binding Protein (Gh-Bp) Induction in Renal Cortex of Streptozotocin (Stz) -Diabetic Rats Pediatric Research. 41: 303-303. DOI: 10.1203/00006450-199702000-00040 |
0.34 |
|
| 1997 |
Paz K, Hemi R, LeRoith D, Karasik A, Kanety H, Zick Y. Molecular basis for insulin resistance: Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtaraembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation Experimental and Clinical Endocrinology and Diabetes. 105: 10. DOI: 10.1055/S-0029-1211820 |
0.461 |
|
| 1996 |
Werner H, Roberts CT, Rauscher FJ, LeRoith D. Regulation of insulin-like growth factor I receptor gene expression by the wilms' tumor supressor WT1 Journal of Molecular Neuroscience. 7: 111-123. PMID 8873895 DOI: 10.1007/Bf02736791 |
0.42 |
|
| 1996 |
Karas M, Kleinman D, Danilenko M, Roberts CT, LeRoith D, Levy J, Sharoni Y. Components of the IGF system mediate the opposing effects of tamoxifen on endometrial and breast cancer cell growth. Progress in Growth Factor Research. 6: 513-20. PMID 8817696 DOI: 10.1016/0955-2235(95)00033-X |
0.417 |
|
| 1996 |
LeRoith D. Insulin-like growth factor receptors and binding proteins. Bailliere's Clinical Endocrinology and Metabolism. 10: 49-73. PMID 8734451 DOI: 10.1016/S0950-351X(96)80298-9 |
0.474 |
|
| 1996 |
Werner H, LeRoith D. The role of the insulin-like growth factor system in human cancer. Advances in Cancer Research. 68: 183-223. PMID 8712068 DOI: 10.1016/S0065-230X(08)60354-1 |
0.492 |
|
| 1996 |
Werner H, Karnieli E, Rauscher FJ, LeRoith D. Wild-type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptor gene Proceedings of the National Academy of Sciences of the United States of America. 93: 8318-8323. PMID 8710868 DOI: 10.1073/Pnas.93.16.8318 |
0.429 |
|
| 1996 |
Karnieli E, Werner H, Rauscher FJ, Benjamin LE, LeRoith D. The IGF-I receptor gene promoter is a molecular target for the Ewing's sarcoma-Wilms' tumor 1 fusion protein. The Journal of Biological Chemistry. 271: 19304-9. PMID 8702614 DOI: 10.1074/Jbc.271.32.19304 |
0.389 |
|
| 1996 |
Matsumura Y, Domeki M, Sugahara K, Kubo T, Roberts CT, LeRoith D, Kato H. Nutritional regulation of insulin-like growth factor-I receptor mRNA levels in growing chickens. Bioscience, Biotechnology, and Biochemistry. 60: 979-82. PMID 8695914 DOI: 10.1271/Bbb.60.979 |
0.459 |
|
| 1996 |
Butler AA, Funk B, Breier BH, LeRoith D, Roberts CT, Gluckman PD. Growth hormone (GH) status regulates GH receptor and GH binding protein mRNA in a tissue- and transcript-specific manner but has no effect on insulin-like growth factor-I receptor mRNA in the rat. Molecular and Cellular Endocrinology. 116: 181-9. PMID 8647318 DOI: 10.1016/0303-7207(95)03713-6 |
0.421 |
|
| 1996 |
Neuenschwander S, Schwartz A, Wood TL, Roberts CT, Hennighausen L, LeRoith D. Involution of the lactating mammary gland is inhibited by the IGF system in a transgenic mouse model. The Journal of Clinical Investigation. 97: 2225-32. PMID 8636401 DOI: 10.1172/Jci118663 |
0.451 |
|
| 1996 |
Paz K, Voliovitch H, Hadari YR, Roberts CT, LeRoith D, Zick Y. Interaction between the insulin receptor and its downstream effectors: Use of individually expressed receptor domains for structure/function analysis Journal of Biological Chemistry. 271: 6998-7003. PMID 8636129 DOI: 10.1074/Jbc.271.12.6998 |
0.324 |
|
| 1996 |
Beitner-Johnson D, Blakesley VA, Shen-Orr Z, Jimenez M, Stannard B, Wang LM, Pierce J, LeRoith D. The proto-oncogene product c-Crk associates with insulin receptor substrate-1 and 4PS. Modulation by insulin growth factor-I (IGF) and enhanced IGF-I signaling. The Journal of Biological Chemistry. 271: 9287-90. PMID 8621590 DOI: 10.1074/Jbc.271.16.9287 |
0.476 |
|
| 1996 |
Kleinman D, Karas M, Danilenko M, Arbell A, Roberts CT, LeRoith D, Levy J, Sharoni Y. Stimulation of endometrial cancer cell growth by tamoxifen is associated with increased insulin-like growth factor (IGF)-I induced tyrosine phosphorylation and reduction in IGF binding proteins. Endocrinology. 137: 1089-95. PMID 8603578 DOI: 10.1210/endo.137.3.8603578 |
0.373 |
|
| 1996 |
LeRoith D, Yanowski J, Kaldjian EP, Jaffe ES, LeRoith T, Purdue K, Cooper BD, Pyle R, Adler W. The effects of growth hormone and insulin-like growth factor I on the immune system of aged female monkeys. Endocrinology. 137: 1071-9. PMID 8603576 DOI: 10.1210/Endo.137.3.8603576 |
0.341 |
|
| 1996 |
Blakesley VA, Kalebic T, Helman LJ, Stannard B, Faria TN, Roberts CT, LeRoith D. Tumorigenic and mitogenic capacities are reduced in transfected fibroblasts expressing mutant insulin-like growth factor (IGF)-I receptors. The role of tyrosine residues 1250, 1251, and 1316 in the carboxy-terminus of the IGF-I receptor. Endocrinology. 137: 410-7. PMID 8593783 DOI: 10.1210/Endo.137.2.8593783 |
0.457 |
|
| 1996 |
Werner H, Hernández-Sánchez C, Karnieli E, Leroith D. The regulation of IGF-I receptor gene expression. The International Journal of Biochemistry & Cell Biology. 27: 987-94. PMID 7497000 DOI: 10.1016/1357-2725(95)00074-Y |
0.486 |
|
| 1996 |
Hernández-Sánchez C, Blakesley V, Kalebic T, Helman L, LeRoith D. The role of the tyrosine kinase domain of the insulin-like growth factor-I receptor in intracellular signaling, cellular proliferation, and tumorigenesis. The Journal of Biological Chemistry. 270: 29176-81. PMID 7493944 DOI: 10.1074/Jbc.270.49.29176 |
0.461 |
|
| 1996 |
Beitner-Johnson D, Werner H, Roberts CT, LeRoith D. Regulation of insulin-like growth factor I receptor gene expression by Sp1: physical and functional interactions of Sp1 at GC boxes and at a CT element. Molecular Endocrinology (Baltimore, Md.). 9: 1147-56. PMID 7491107 DOI: 10.1210/Mend.9.9.7491107 |
0.374 |
|
| 1996 |
Toretsky JA, Kalebic T, Blakesley V, LeRoith D, Helman L, Moscow J. #511 Insulin-like Growth Factor-I Receptor is Necessary for EWS/FLI-1 Induced Transformation of Fibroblasts Journal of Pediatric Hematology/Oncology. 18: 430. DOI: 10.1097/00043426-199611000-00034 |
0.36 |
|
| 1996 |
LeRoith D, Bondy C. Insulin-like growth factors Growth Factors and Cytokines in Health and Disease. 1: 1-26. DOI: 10.1016/S1874-5687(96)80003-6 |
0.333 |
|
| 1995 |
LeRoith D, Neuenschwander S, Wood TL, Hennighausen L. Insulin-like growth factor-I and insulin-like growth factor binding protein-3 inhibit involution of the mammary gland following lactation: studies in transgenic mice. Progress in Growth Factor Research. 6: 433-6. PMID 8817687 DOI: 10.1016/0955-2235(96)00009-9 |
0.459 |
|
| 1995 |
Yang H, Adamo ML, Koval AP, McGuinness MC, Ben-Hur H, Yang Y, LeRoith D, Roberts CT. Alternative leader sequences in insulin-like growth factor I mRNAs modulate translational efficiency and encode multiple signal peptides Molecular Endocrinology. 9: 1380-1395. PMID 8544846 DOI: 10.1210/Mend.9.10.8544846 |
0.619 |
|
| 1995 |
Domené HM, Cassorla F, Werner H, Roberts CT, Leroith D. Rat growth hormone receptor/growth hormone-binding protein mRNAs with divergent 5'-untranslated regions are expressed in a tissue-specific manner. Dna and Cell Biology. 14: 195-204. PMID 7880440 DOI: 10.1089/Dna.1995.14.195 |
0.336 |
|
| 1995 |
Blakesley VA, Kato H, Roberts CT, LeRoith D. Mutation of a conserved amino acid residue (tryptophan 1173) in the tyrosine kinase domain of the IGF-I receptor abolishes autophosphorylation but does not eliminate biologic function. The Journal of Biological Chemistry. 270: 2764-9. PMID 7852347 DOI: 10.1074/Jbc.270.6.2764 |
0.448 |
|
| 1995 |
Pash JM, Delany AM, Adamo ML, Roberts CT, LeRoith D, Canalis E. Regulation of insulin-like growth factor I transcription by prostaglandin E2 in osteoblast cells Endocrinology. 136: 33-38. PMID 7828549 DOI: 10.1210/Endo.136.1.7828549 |
0.658 |
|
| 1995 |
Werner H, Shen-Orr Z, Rauscher FJ, Morris JF, Roberts CT, LeRoith D. Inhibition of cellular proliferation by the Wilms' tumor suppressor WT1 is associated with suppression of insulin-like growth factor I receptor gene expression Molecular and Cellular Biology. 15: 3516-3522. PMID 7791758 DOI: 10.1128/Mcb.15.7.3516 |
0.433 |
|
| 1995 |
Kleinman D, Karas M, Roberts CT, LeRoith D, Phillip M, Segev Y, Levy J, Sharoni Y. Modulation of insulin-like growth factor I (IGF-I) receptors and membrane-associated IGF-binding proteins in endometrial cancer cells by estradiol. Endocrinology. 136: 2531-7. PMID 7750475 DOI: 10.1210/endo.136.6.7750475 |
0.398 |
|
| 1995 |
LeRoith D. A novel Drosophila insulin receptor: fly in the ointment or evolutionary conservation? Endocrinology. 136: 2355-6. PMID 7750455 DOI: 10.1210/endo.136.6.7750455 |
0.349 |
|
| 1995 |
Surmacz E, Sell C, Swantek J, Kato H, Roberts CT, LeRoith D, Baserga R. Dissociation of mitogenesis and transforming activity by C-terminal truncation of the insulin-like growth factor-I receptor. Experimental Cell Research. 218: 370-80. PMID 7737373 DOI: 10.1006/Excr.1995.1168 |
0.426 |
|
| 1995 |
Malozowski S, Parmer TG, Trojan S, Merriam GR, Gibori G, Roberts CT, LeRoith D, Werner H, Zilberstein M. Growth hormone (GH) modulates insulin-like growth factor I (IGF-I) and type I IGF receptor mRNA levels in the ovary of prepubertal GH-deficient rats. European Journal of Endocrinology / European Federation of Endocrine Societies. 132: 497-501. PMID 7711889 DOI: 10.1530/eje.0.1320497 |
0.325 |
|
| 1995 |
Edmondson SR, Werther GA, Russell A, LeRoith D, Roberts CT, Beck F. Localization of growth hormone receptor/binding protein messenger ribonucleic acid (mRNA) during rat fetal development: relationship to insulin-like growth factor-I mRNA. Endocrinology. 136: 4602-9. PMID 7664680 DOI: 10.1210/endo.136.10.7664680 |
0.33 |
|
| 1995 |
Neuenschwander S, Roberts CT, LeRoith D. Growth inhibition of MCF-7 breast cancer cells by stable expression of an insulin-like growth factor I receptor antisense ribonucleic acid. Endocrinology. 136: 4298-303. PMID 7664648 DOI: 10.1210/Endo.136.10.7664648 |
0.444 |
|
| 1995 |
Potashnik G, Lunenfeld E, Shwartz I, Glezerman M, Roberts CT, LeRoith D, Sharoni Y, Levy J. Endogenous plasma growth hormone and the occurrence of pregnancies in patients undergoing in-vitro fertilization and embryo transfer with ovarian stimulation. Human Reproduction (Oxford, England). 10: 1065-9. PMID 7657742 DOI: 10.1093/Oxfordjournals.Humrep.A136095 |
0.334 |
|
| 1995 |
LeRoith D, Baserga R, Helman L, Roberts CT. Insulin-like growth factors and cancer. Annals of Internal Medicine. 122: 54-9. PMID 7619109 DOI: 10.7326/0003-4819-122-1-199501010-00009 |
0.478 |
|
| 1995 |
Katz J, Weiss H, Goldman B, Kanety H, Stannard B, LeRoith D, Shemer J. Cytokines and growth factors modulate cell growth and insulin-like growth factor binding protein secretion by the human salivary cell line (HSG). Journal of Cellular Physiology. 165: 223-7. PMID 7593199 DOI: 10.1002/Jcp.1041650202 |
0.46 |
|
| 1995 |
Stannard B, Blakesley V, Kato H, Roberts CT, LeRoith D. Single tyrosine substitution in the insulin-like growth factor I receptor inhibits ligand-induced receptor autophosphorylation and internalization, but not mitogenesis. Endocrinology. 136: 4918-24. PMID 7588225 DOI: 10.1210/Endo.136.11.7588225 |
0.445 |
|
| 1995 |
LeRoith D, Werner H, Beitner-Johnson D, Roberts CT. Molecular and cellular aspects of the insulin-like growth factor I receptor. Endocrine Reviews. 16: 143-63. PMID 7540132 DOI: 10.1210/Edrv-16-2-143 |
0.51 |
|
| 1995 |
Landau D, Chin E, Bondy C, Domene H, Roberts CT, Gronbaek H, Flyvbjerg A, LeRoith D. Expression of insulin-like growth factor binding proteins in the rat kidney: effects of long-term diabetes. Endocrinology. 136: 1835-42. PMID 7536658 DOI: 10.1210/Endo.136.5.7536658 |
0.404 |
|
| 1995 |
Beitner-Johnson D, LeRoith D. Insulin-like growth factor-I stimulates tyrosine phosphorylation of endogenous c-Crk. The Journal of Biological Chemistry. 270: 5187-90. PMID 7534289 DOI: 10.1074/Jbc.270.10.5187 |
0.46 |
|
| 1995 |
Yakar S, Domene H, Meidan R, Cassorla F, Gilad I, Koch I, Laron Z, Roberts CT, LeRoith D, Eshet R. Growth hormone (GH) stimulates insulin-like growth factor-I (IGF-I) and IGF-binding protein (IGFBP)-2 gene expression in spleens of juvenile rats. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme. 26: 363-6. PMID 7528707 DOI: 10.1055/S-2007-1001707 |
0.489 |
|
| 1995 |
Domené HM, Meidan R, Yakar S, Shen-Orr Z, Cassorla F, Roberts CT, LeRoith D. Role of GH and IGF-I in the regulation of IGF-I, IGF-I receptor and IGF binding protein gene expression in the rat spleen. Regulatory Peptides. 52: 215-26. PMID 7528435 DOI: 10.1016/0167-0115(94)90056-6 |
0.39 |
|
| 1995 |
LeRoith D, Werner H, Neuenschwander S, Kalebic T, Helman LJ. The role of the insulin-like growth factor-I receptor in cancer. Annals of the New York Academy of Sciences. 766: 402-8. PMID 7486685 DOI: 10.1111/J.1749-6632.1995.Tb26689.X |
0.479 |
|
| 1995 |
Flyvbjerg A, Landau D, Domene H, Hernandez L, Grønbaek H, LeRoith D. The role of growth hormone, insulin-like growth factors (IGFs), and IGF-binding proteins in experimental diabetic kidney disease. Metabolism: Clinical and Experimental. 44: 67-71. PMID 7476314 DOI: 10.1016/0026-0495(95)90223-6 |
0.427 |
|
| 1995 |
Domené HM, Leroith D, Roberts CT, Cassorla F. RAT GH RECEPTOR/GH-BINDING PROTEIN mRNAs KITH DIVERGENT 5′-UNTRANSLATED REGIONS ARE EXPRESSED IN A TISSUE- AND TRANSCRIPT-SPECIFIC MANNER Pediatric Research. 38: 626-626. DOI: 10.1203/00006450-199510000-00056 |
0.327 |
|
| 1994 |
Butler AA, Ambler GR, Breier BH, LeRoith D, Roberts CT, Gluckman PD. Growth hormone (GH) and insulin-like growth factor-I (IGF-I) treatment of the GH-deficient dwarf rat: differential effects on IGF-I transcription start site expression in hepatic and extrahepatic tissues and lack of effect on type I IGF receptor mRNA expression. Molecular and Cellular Endocrinology. 101: 321-30. PMID 9397967 DOI: 10.1016/0303-7207(94)90249-6 |
0.433 |
|
| 1994 |
Kleinman D, Roberts CT, LeRoith D, Schally AV, Levy J, Sharoni Y. Regulation of endometrial cancer cell growth by insulin-like growth factors and the luteinizing hormone-releasing hormone antagonist SB-75. Regulatory Peptides. 48: 91-8. PMID 8265821 DOI: 10.1016/0167-0115(93)90338-9 |
0.463 |
|
| 1994 |
Werner H, Roberts CT, LeRoith D. The regulation of IGF-I receptor gene expression by positive and negative zinc-finger transcription factors. Advances in Experimental Medicine and Biology. 343: 91-103. PMID 8184747 DOI: 10.1007/978-1-4615-2988-0_10 |
0.342 |
|
| 1994 |
Rubini M, Werner H, Gandini E, Roberts CT, LeRoith D, Baserga R. Platelet-derived growth factor increases the activity of the promoter of the insulin-like growth factor-1 (IGF-1) receptor gene. Experimental Cell Research. 211: 374-9. PMID 8143786 DOI: 10.1006/Excr.1994.1101 |
0.467 |
|
| 1994 |
LeRoith D, Sampson PC, Roberts CT. How does the mitogenic insulin-like growth factor I receptor differ from the metabolic insulin receptor? Hormone Research. 41: 74-8; discussion 79. PMID 8088708 DOI: 10.1159/000183964 |
0.425 |
|
| 1994 |
el-Roeiy A, Chen X, Roberts VJ, LeRoith D, Roberts CT, Yen SS. Expression of insulin-like growth factor-I (IGF-I) and IGF-II and the IGF-I, IGF-II, and insulin receptor genes and localization of the gene products in the human ovary. The Journal of Clinical Endocrinology and Metabolism. 77: 1411-8. PMID 8077342 DOI: 10.1210/jcem.77.5.8077342 |
0.398 |
|
| 1994 |
Bikle DD, Harris J, Halloran BP, Roberts CT, Leroith D, Morey-Holton E. Expression of the genes for insulin-like growth factors and their receptors in bone during skeletal growth. The American Journal of Physiology. 267: E278-86. PMID 8074208 DOI: 10.1152/Ajpendo.1994.267.2.E278 |
0.473 |
|
| 1994 |
Kavsan VM, Grebenjuk VA, Koval AP, Skorokhod AS, Roberts CT, Leroith D. Isolation of a second nonallelic insulin-like growth factor I gene from the salmon genome. Dna and Cell Biology. 13: 555-9. PMID 8024699 DOI: 10.1089/Dna.1994.13.555 |
0.436 |
|
| 1994 |
Menon RK, Stephan DA, Rao RH, Shen-Orr Z, Downs LS, Roberts CT, LeRoith D, Sperling MA. Tissue-specific regulation of the growth hormone receptor gene in streptozocin-induced diabetes in the rat. The Journal of Endocrinology. 142: 453-62. PMID 7964296 DOI: 10.1677/joe.0.1420453 |
0.328 |
|
| 1994 |
Koval A, Kulik V, Duguay S, Plisetskaya E, Adamo ML, Roberts CT, LeRoith D, Kavsan V. Characterization of a salmon insulin-like growth factor I promoter Dna and Cell Biology. 13: 1057-1062. PMID 7945938 DOI: 10.1089/Dna.1994.13.1057 |
0.661 |
|
| 1994 |
LeRoith D, Roberts CT. Insulin-like growth factors and their receptors in normal physiology and pathological states. The Journal of Pediatric Endocrinology. 6: 251-5. PMID 7920991 DOI: 10.1515/Jpem.1993.6.3-4.251 |
0.503 |
|
| 1994 |
Werner H, Adamo M, Roberts CT, LeRoith D. Molecular and cellular aspects of insulin-like growth factor action. Vitamins and Hormones. 48: 1-58. PMID 7524243 DOI: 10.1016/S0083-6729(08)60495-1 |
0.713 |
|
| 1994 |
Phillip M, Werner H, Palese T, Kowarski AA, Stannard B, Bach LA, LeRoith D, Roberts CT. Differential accumulation of insulin-like growth factor-I in kidneys of pre- and postpubertal streptozotocin-diabetic rats. Journal of Molecular Endocrinology. 12: 215-24. PMID 7520245 DOI: 10.1677/Jme.0.0120215 |
0.424 |
|
| 1994 |
Mastick CC, Kato H, Roberts CT, LeRoith D, Saltiel AR. Insulin and insulin-like growth factor-I receptors similarly stimulate deoxyribonucleic acid synthesis despite differences in cellular protein tyrosine phosphorylation Endocrinology. 135: 214-222. PMID 7516864 DOI: 10.1210/Endo.135.1.7516864 |
0.367 |
|
| 1994 |
el-Roeiy A, Chen X, Roberts VJ, Shimasakai S, Ling N, LeRoith D, Roberts CT, Yen SS. Expression of the genes encoding the insulin-like growth factors (IGF-I and II), the IGF and insulin receptors, and IGF-binding proteins-1-6 and the localization of their gene products in normal and polycystic ovary syndrome ovaries. The Journal of Clinical Endocrinology and Metabolism. 78: 1488-96. PMID 7515389 DOI: 10.1210/jcem.78.6.7515389 |
0.323 |
|
| 1994 |
Kato H, Faria TN, Stannard B, Roberts CT, LeRoith D. Essential role of tyrosine residues 1131, 1135, and 1136 of the insulin-like growth factor-I (IGF-I) receptor in IGF-I action. Molecular Endocrinology (Baltimore, Md.). 8: 40-50. PMID 7512194 DOI: 10.1210/Mend.8.1.7512194 |
0.476 |
|
| 1994 |
Chen JC, Shao ZM, Sheikh MS, Hussain A, LeRoith D, Roberts CT, Fontana JA. Insulin-like growth factor-binding protein enhancement of insulin-like growth factor-I (IGF-I)-mediated DNA synthesis and IGF-I binding in a human breast carcinoma cell line. Journal of Cellular Physiology. 158: 69-78. PMID 7505280 DOI: 10.1002/Jcp.1041580110 |
0.467 |
|
| 1993 |
Botero LF, Roberts CT, LeRoith D, Adashi EY, Hernandez ER. Insulin-like growth factor I gene expression by primary cultures of ovarian cells: insulin and dexamethasone dependence. Endocrinology. 132: 2703-8. PMID 8504770 DOI: 10.1210/endo.132.6.8504770 |
0.392 |
|
| 1993 |
Woloschak M, Shen-Orr Z, LeRoith D, Roberts CT. Nutritional regulation of insulin-sensitive glucose transporter gene expression in rat cardiac muscle. Proceedings of the Society For Experimental Biology and Medicine. Society For Experimental Biology and Medicine (New York, N.Y.). 203: 172-4. PMID 8502658 DOI: 10.3181/00379727-203-43588 |
0.436 |
|
| 1993 |
Eshet R, Werner H, Klinger B, Silbergeld A, Laron Z, LeRoith D, Roberts CT. Up-regulation of insulin-like growth factor-I (IGF-I) receptor gene expression in patients with reduced serum IGF-I levels Journal of Molecular Endocrinology. 10: 115-120. PMID 8484860 DOI: 10.1677/Jme.0.0100115 |
0.438 |
|
| 1993 |
Kavsan V, Koval A, Petrenko O, Roberts CT, LeRoith D. Two insulin genes are present in the salmon genome. Biochemical and Biophysical Research Communications. 191: 1373-8. PMID 8466513 DOI: 10.1006/Bbrc.1993.1369 |
0.319 |
|
| 1993 |
Adamo ML, Lanau F, Neuenschwander S, Werner H, LeRoith D, Roberts CT. Distinct promoters in the rat insulin-like growth factor-I (IGF-I) gene are active in CHO cells. Endocrinology. 132: 935-7. PMID 8425505 DOI: 10.1210/Endo.132.2.8425505 |
0.621 |
|
| 1993 |
Hershkovitz E, Marbach M, Bosin E, Levy J, Roberts CT, LeRoith D, Schally AV, Sharoni Y. Luteinizing hormone-releasing hormone antagonists interfere with autocrine and paracrine growth stimulation of MCF-7 mammary cancer cells by insulin-like growth factors. The Journal of Clinical Endocrinology and Metabolism. 77: 963-8. PMID 8408472 DOI: 10.1210/jcem.77.4.8408472 |
0.353 |
|
| 1993 |
LeRoith D, Kavsan VM, Koval AP, Roberts CT. Phylogeny of the insulin-like growth factors (IGFs) and receptors: a molecular approach. Molecular Reproduction and Development. 35: 332-6; discussion 33. PMID 8398110 DOI: 10.1002/Mrd.1080350403 |
0.502 |
|
| 1993 |
Kavsan VM, Koval AP, Grebenjuk VA, Chan SJ, Steiner DF, Roberts CT, LeRoith D. Structure of the chum salmon insulin-like growth factor I gene Dna and Cell Biology. 12: 729-737. PMID 8397830 DOI: 10.1089/Dna.1993.12.729 |
0.377 |
|
| 1993 |
Werner H, Re GG, Drummond IA, Sukhatme VP, Rauscher FJ, Sens DA, Garvin AJ, Leroith D, Roberts CT. Increased expression of the insulin-like growth factor I receptor gene, IGF1R, in Wilms tumor is correlated with modulation of IGF1R promoter activity by the WT1 Wilms tumor gene product Proceedings of the National Academy of Sciences of the United States of America. 90: 5828-5832. PMID 8390684 DOI: 10.1073/Pnas.90.12.5828 |
0.416 |
|
| 1993 |
LeRoith D, Werner H, Phillip M, Roberts CT. The role of insulin-like growth factors in diabetic kidney disease. American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation. 22: 722-6. PMID 8238020 DOI: 10.1016/S0272-6386(12)80438-0 |
0.449 |
|
| 1993 |
LeRoith D, Roberts CT. Insulin-like growth factors. Annals of the New York Academy of Sciences. 692: 1-9. PMID 8215015 DOI: 10.1111/J.1749-6632.1993.Tb26200.X |
0.394 |
|
| 1993 |
Adamo ML, Neuenschwander S, LeRoith D, Roberts CT. Structure, expression, and regulation of the IGF-I gene. Advances in Experimental Medicine and Biology. 343: 1-11. PMID 8184730 DOI: 10.1007/978-1-4615-2988-0_1 |
0.708 |
|
| 1993 |
Hadari YR, Geiger B, Nadiv O, Sabanay I, Roberts CT, LeRoith D, Zick Y. Hepatic tyrosine-phosphorylated proteins identified and localized following in vivo inhibition of protein tyrosine phosphatases: effects of H2O2 and vanadate administration into rat livers Molecular and Cellular Endocrinology. 97: 9-17. PMID 8143908 DOI: 10.1016/0303-7207(93)90206-Y |
0.325 |
|
| 1993 |
LeRoith D, Werner H, Faria TN, Kato H, Adamo M, Roberts CT. Insulin-like growth factor receptors. Implications for nervous system function. Annals of the New York Academy of Sciences. 692: 22-32. PMID 7692787 DOI: 10.1111/J.1749-6632.1993.Tb26202.X |
0.711 |
|
| 1993 |
Adamo ML, Shemer J, Roberts CT, LeRoith D. Insulin and insulin-like growth factor-I induced phosphorylation in neurally derived cells Annals of the New York Academy of Sciences. 692: 113-125. PMID 7692785 DOI: 10.1111/J.1749-6632.1993.Tb26210.X |
0.708 |
|
| 1993 |
Domené H, Krishnamurthi K, Eshet R, Gilad I, Laron Z, Koch I, Stannard B, Cassorla F, Roberts CT, LeRoith D. Growth hormone (GH) stimulates insulin-like growth factor-I (IGF-I) and IGF-I-binding protein-3, but not GH receptor gene expression in livers of juvenile rats. Endocrinology. 133: 675-82. PMID 7688291 DOI: 10.1210/Endo.133.2.7688291 |
0.446 |
|
| 1993 |
Kato H, Faria TN, Stannard B, Levy-Toledano R, Taylor SI, Roberts CT, LeRoith D. Paradoxical biological effects of overexpressed insulin-Like growth factor-1 receptors in Chinese hamster ovary cells Journal of Cellular Physiology. 156: 145-152. PMID 7686165 DOI: 10.1002/Jcp.1041560120 |
0.493 |
|
| 1993 |
Sheikh MS, Shao ZM, Hussain A, Clemmons DR, Chen JC, Roberts CT, LeRoith D, Fontana JA. Regulation of insulin-like growth factor-binding-protein-1, 2, 3, 4, 5, and 6: synthesis, secretion, and gene expression in estrogen receptor-negative human breast carcinoma cells. Journal of Cellular Physiology. 155: 556-67. PMID 7684042 DOI: 10.1002/Jcp.1041550314 |
0.435 |
|
| 1993 |
Shemer J, Yaron A, Werner H, Shao ZM, Sheikh MS, Fontana JA, LeRoith D, Roberts CT. Regulation of insulin-like growth factor (IGF) binding protein-5 in the T47D human breast carcinoma cell line by IGF-I and retinoic acid. The Journal of Clinical Endocrinology and Metabolism. 77: 1246-50. PMID 7521344 DOI: 10.1210/Jcem.77.5.7521344 |
0.497 |
|
| 1993 |
LeRoith D, McGuinness M, Shemer J, Stannard B, Lanau F, Faria TN, Kato H, Werner H, Adamo M, Roberts CT. Insulin-like growth factors. Biological Signals. 1: 173-81. PMID 1307923 DOI: 10.1159/000109323 |
0.725 |
|
| 1993 |
Foyt HL, Lanau F, Woloschak M, LeRoith D, Roberts CT. Effect of growth hormone on levels of differentially processed insulin-like growth factor I mRNAs in total and polysomal mRNA populations. Molecular Endocrinology (Baltimore, Md.). 6: 1881-8. PMID 1282673 DOI: 10.1210/Mend.6.11.1282673 |
0.393 |
|
| 1992 |
LeRoith D, Roberts CT. Insulin-like growth factor I (IGF-I): a molecular basis for endocrine versus local action? Molecular and Cellular Endocrinology. 77: C57-61. PMID 1815991 DOI: 10.1016/0303-7207(91)90054-V |
0.378 |
|
| 1992 |
Hernandez ER, Hurwitz A, Botero L, Ricciarelli E, Werner H, Roberts CT, LeRoith D, Adashi EY. Insulin-like growth factor receptor gene expression in the rat ovary: divergent regulation of distinct receptor species. Molecular Endocrinology (Baltimore, Md.). 5: 1799-805. PMID 1724286 DOI: 10.1210/Mend-5-12-1799 |
0.487 |
|
| 1992 |
Adashi EY, Resnick CE, Hurwitz A, Ricciarelli E, Hernandez ER, Roberts CT, Leroith D, Rosenfeld R. Insulin-like growth factors: the ovarian connection. Human Reproduction (Oxford, England). 6: 1213-9. PMID 1721620 DOI: 10.1093/Oxfordjournals.Humrep.A137514 |
0.491 |
|
| 1992 |
Werner H, Stannard B, Bach MA, Roberts CT, LeRoith D. Regulation of insulin-like growth factor I receptor gene expression in normal and pathological states. Advances in Experimental Medicine and Biology. 293: 263-72. PMID 1662862 DOI: 10.1007/978-1-4684-5949-4_24 |
0.513 |
|
| 1992 |
Werner H, Bach MA, Stannard B, Roberts CT, LeRoith D. Structural and functional analysis of the insulin-like growth factor I receptor gene promoter. Molecular Endocrinology (Baltimore, Md.). 6: 1545-58. PMID 1448110 DOI: 10.1210/Mend.6.10.1448110 |
0.424 |
|
| 1992 |
Shemer J, Adamo ML, Roberts CT, Leroith D. Tissue-specific transcription start site usage in the leader exons of the rat insulin-like growth factor-I gene: Evidence for differential regulation in the developing kidney Endocrinology. 131: 2793-2799. PMID 1446616 DOI: 10.1210/Endo.131.6.1446616 |
0.648 |
|
| 1992 |
Porcu P, Ferber A, Pietrzkowski Z, Roberts CT, Adamo M, Leroith D, Baserga R. The growth-stimulatory effect of simian virus 40 T antigen requires the interaction of insulinlike growth factor 1 with its receptor Molecular and Cellular Biology. 12: 5069-5077. PMID 1406682 DOI: 10.1128/Mcb.12.11.5069 |
0.669 |
|
| 1992 |
Adamo ML, Shao ZM, Lanau F, Chen JC, Clemmons DR, Roberts CT, Leroith D, Fontana JA. Insulin-like growth factor-I (IGF-I) and retinoic acid modulation of IGF-binding proteins (IGFBPs): IGFBP-2, -3, and -4 gene expression and protein secretion in a breast cancer cell line Endocrinology. 131: 1858-1866. PMID 1382963 DOI: 10.1210/Endo.131.4.1382963 |
0.679 |
|
| 1992 |
Sheikh MS, Shao ZM, Clemmons DR, LeRoith D, Roberts CT, Fontana JA. Identification of the insulin-like growth factor binding proteins 5 and 6 (IGFBP-5 and 6) in human breast cancer cells. Biochemical and Biophysical Research Communications. 183: 1003-10. PMID 1373605 DOI: 10.1016/S0006-291X(05)80290-6 |
0.415 |
|
| 1992 |
LeRoith D, Clemmons D, Nissley P, Rechler MM. NIH conference. Insulin-like growth factors in health and disease. Annals of Internal Medicine. 116: 854-62. PMID 1373590 DOI: 10.7326/0003-4819-116-10-854 |
0.462 |
|
| 1992 |
Levy MJ, Hernandez ER, Adashi EY, Stillman RJ, Roberts CT, LeRoith D. Expression of the insulin-like growth factor (IGF)-I and -II and the IGF-I and -II receptor genes during postnatal development of the rat ovary. Endocrinology. 131: 1202-6. PMID 1324154 DOI: 10.1210/Endo.131.3.1324154 |
0.452 |
|
| 1992 |
Sklar MM, Thomas CL, Municchi G, Roberts CT, LeRoith D, Kiess W, Nissley P. Developmental expression of rat insulin-like growth factor-II/mannose 6- phosphate receptor messenger ribonucleic acid Endocrinology. 130: 3484-3491. PMID 1317785 DOI: 10.1210/Endo.130.6.1317785 |
0.416 |
|
| 1992 |
Mulroney SE, Lumpkin MD, Roberts CT, LeRoith D, Haramati A. Effect of a growth hormone-releasing factor antagonist on compensatory renal growth, insulin-like growth factor-I (IGF-I), and IGF-I receptor gene expression after unilateral nephrectomy in immature rats. Endocrinology. 130: 2697-702. PMID 1315253 DOI: 10.1210/endo.130.5.1315253 |
0.327 |
|
| 1992 |
Bondy C, Werner H, Roberts CT, LeRoith D. Cellular pattern of type-I insulin-like growth factor receptor gene expression during maturation of the rat brain: comparison with insulin-like growth factors I and II. Neuroscience. 46: 909-23. PMID 1311816 DOI: 10.1016/0306-4522(92)90193-6 |
0.518 |
|
| 1992 |
Hernandez ER, Hurwitz A, Vera A, Pellicer A, Adashi EY, LeRoith D, Roberts CT. Expression of the genes encoding the insulin-like growth factors and their receptors in the human ovary. The Journal of Clinical Endocrinology and Metabolism. 74: 419-25. PMID 1309838 DOI: 10.1210/jcem.74.2.1309838 |
0.398 |
|
| 1992 |
Mulroney SE, Haramati A, Werner H, Bondy C, Roberts CT, LeRoith D. Altered expression of insulin-like growth factor-I (IGF-I) and IGF receptor genes after unilateral nephrectomy in immature rats. Endocrinology. 130: 249-56. PMID 1309331 DOI: 10.1210/endo.130.1.1309331 |
0.328 |
|
| 1992 |
LeRoith D, Werner H, Burguera B, Roberts CT, Mulroney S, Haramati A. The insulin-like growth factor family of peptides, binding proteins and receptors: their potential role in tissue regeneration. Advances in Experimental Medicine and Biology. 321: 21-8; discussion 29-. PMID 1280399 DOI: 10.1007/978-1-4615-3448-8_3 |
0.493 |
|
| 1992 |
Sheikh MS, Shao ZM, Chen JC, Clemmons DR, Roberts CT, LeRoith D, Fontana JA. Insulin-like growth factor binding protein-5 gene expression is differentially regulated at a post-transcriptional level in retinoic acid-sensitive and resistant MCF-7 human breast carcinoma cells. Biochemical and Biophysical Research Communications. 188: 1122-30. PMID 1280130 DOI: 10.1016/0006-291X(92)91348-T |
0.428 |
|
| 1992 |
Roberts C, LeRoith D. Interactions in the Insulin-Like Growth Factor Signaling System Physiology. 7: 69-72. DOI: 10.1152/physiologyonline.1992.7.2.69 |
0.406 |
|
| 1992 |
Raizada MK, Rydzewski BZ, Werner H, Masters BA, Roberts CT, LeRoith D. Rat Brain/Hep G2 Glucose Transporter Gene Expression in Brain Methods in Neurosciences. 9: 79-88. DOI: 10.1016/B978-0-12-185267-2.50011-8 |
0.3 |
|
| 1991 |
Hernandez ER, Roberts CT, Hurwitz A, LeRoith D, Adashi EY. Rat ovarian insulin-like growth factor II gene expression is theca-interstitial cell-exclusive: hormonal regulation and receptor distribution. Endocrinology. 127: 3249-51. PMID 2174350 DOI: 10.1210/Endo-127-6-3249 |
0.46 |
|
| 1991 |
Werner H, Shen-Orr Z, Stannard B, Burguera B, Roberts CT, LeRoith D. Experimental diabetes increases insulinlike growth factor I and II receptor concentration and gene expression in kidney. Diabetes. 39: 1490-7. PMID 2174008 DOI: 10.2337/Diab.39.12.1490 |
0.482 |
|
| 1991 |
Adamo ML, Ben-Hur H, Leroith D, Roberts CT. Transcription initiation in the two leader exons of the rat IGF-I gene occurs from disperse versus localized sites Biochemical and Biophysical Research Communications. 176: 887-893. PMID 2025299 DOI: 10.1016/S0006-291X(05)80269-4 |
0.621 |
|
| 1991 |
Jansen E, Steenbergh PH, LeRoith D, Roberts CT, Sussenbach JS. Identification of multiple transcription start sites in the human insulin-like growth factor-I gene. Molecular and Cellular Endocrinology. 78: 115-25. PMID 1936520 DOI: 10.1016/0303-7207(91)90192-U |
0.384 |
|
| 1991 |
Masters BA, Werner H, Roberts CT, Leroith D, Raizada MK. Developmental regulation of insulin-like growth factor-I-stimulated glucose transporter in rat brain astrocytes Endocrinology. 128: 2548-2557. PMID 1850355 DOI: 10.1210/Endo-128-5-2548 |
0.351 |
|
| 1991 |
Adamo ML, Ben-Hur H, Roberts CT, LeRoith D. Regulation of start site usage in the leader exons of the rat insulin-like growth factor-i gene by development, fasting, and diabetes Molecular Endocrinology. 5: 1677-1686. PMID 1779970 DOI: 10.1210/Mend-5-11-1677 |
0.675 |
|
| 1991 |
Waldbillig RJ, Pfeffer BA, Schoen TJ, Adler AA, Shen-Orr Z, Scavo L, LeRoith D, Chader GJ. Evidence for an insulin-like growth factor autocrine-paracrine system in the retinal photoreceptor-pigment epithelial cell complex. Journal of Neurochemistry. 57: 1522-33. PMID 1717648 DOI: 10.1111/j.1471-4159.1991.tb06347.x |
0.35 |
|
| 1991 |
Cooke DW, Bankert LA, Roberts CT, LeRoith D, Casella SJ. Analysis of the human type I insulin-like growth factor receptor promoter region. Biochemical and Biophysical Research Communications. 177: 1113-20. PMID 1711844 DOI: 10.1016/0006-291X(91)90654-P |
0.36 |
|
| 1991 |
Adashi EY, Resnick CE, Hernandez ER, Hurwitz A, Roberts CT, Leroith D, Rosenfeld R. Insulin-like growth factor I as an intraovarian regulator: basic and clinical implications. Annals of the New York Academy of Sciences. 626: 161-8. PMID 1711822 DOI: 10.1111/J.1749-6632.1991.Tb37910.X |
0.447 |
|
| 1991 |
Fontana JA, Burrows-Mezu A, Clemmons DR, LeRoith D. Retinoid modulation of insulin-like growth factor-binding proteins and inhibition of breast carcinoma proliferation. Endocrinology. 128: 1115-22. PMID 1703480 DOI: 10.1210/Endo-128-2-1115 |
0.435 |
|
| 1991 |
Wood TL, Berelowitz M, Gelato MC, Roberts CT, LeRoith D, Millard WJ, McKelvy JF. Hormonal regulation of rat hypothalamic neuropeptide mRNAs: effect of hypophysectomy and hormone replacement on growth-hormone-releasing factor, somatostatin and the insulin-like growth factors. Neuroendocrinology. 53: 298-305. PMID 1674982 DOI: 10.1159/000125732 |
0.436 |
|
| 1991 |
Parmer TG, Roberts CT, LeRoith D, Adashi EY, Khan I, Solan N, Nelson S, Zilberstein M, Gibori G. Expression, action, and steroidal regulation of insulin-like growth factor-I (IGF-I) and IGF-I receptor in the rat corpus luteum: their differential role in the two cell populations forming the corpus luteum. Endocrinology. 129: 2924-32. PMID 1659518 DOI: 10.1210/endo-129-6-2924 |
0.385 |
|
| 1991 |
Masters BA, Werner H, Roberts CT, LeRoith D, Raizada MK. Insulin-like growth factor I (IGF-I) receptors and IGF-I action in oligodendrocytes from rat brains Regulatory Peptides. 33: 117-131. PMID 1652776 DOI: 10.1016/0167-0115(91)90207-W |
0.387 |
|
| 1991 |
Bach MA, Shen-Orr Z, Lowe WL, Roberts CT, LeRoith D. Insulin-like growth factor I mRNA levels are developmentally regulated in specific regions of the rat brain. Brain Research. Molecular Brain Research. 10: 43-8. PMID 1647481 DOI: 10.1016/0169-328X(91)90054-2 |
0.443 |
|
| 1991 |
LeRoith D, Adamo M, Werner H, Roberts CT. Insulinlike growth factors and their receptors as growth regulators in normal physiology and pathologic states Trends in Endocrinology & Metabolism. 2: 134-139. DOI: 10.1016/1043-2760(91)90003-6 |
0.664 |
|
| 1990 |
Shemer J, Adamo M, Raizada MK, Heffez D, Zick Y, LeRoith D. Insulin and IGF-I stimulate phosphorylation of their respective receptors in intact neuronal and glial cells in primary culture. Journal of Molecular Neuroscience : Mn. 1: 3-8. PMID 2561992 DOI: 10.1007/Bf02896850 |
0.689 |
|
| 1990 |
Ota A, Shen-Orr Z, LeRoith D. Insulin and IGF-I receptors in neuroblastoma cells: increases in mRNA and binding produced by glyburide. Neuropeptides. 14: 171-5. PMID 2559356 DOI: 10.1016/0143-4179(89)90041-3 |
0.386 |
|
| 1990 |
Serrano J, Shuldiner AR, Roberts CT, LeRoith D, de Pablo F. The insulin-like growth factor I (IGF-I) gene is expressed in chick embryos during early organogenesis. Endocrinology. 127: 1547-9. PMID 2387267 DOI: 10.1210/Endo-127-3-1547 |
0.42 |
|
| 1990 |
Bach MA, Roberts CT, Smith EP, LeRoith D. Alternative splicing produces messenger RNAs encoding insulin-like growth factor-I prohormones that are differentially glycosylated in vitro. Molecular Endocrinology (Baltimore, Md.). 4: 899-904. PMID 2233747 DOI: 10.1210/Mend-4-6-899 |
0.409 |
|
| 1990 |
Burguera B, Werner H, Sklar M, Shen-Orr Z, Stannard B, Roberts CT, Nissley SP, Vore SJ, Caro JF, LeRoith D. Liver regeneration is associated with increased expression of the insulin-like growth factor-II/mannose-6-phosphate receptor Molecular Endocrinology. 4: 1539-1545. PMID 2178219 DOI: 10.1210/Mend-4-10-1539 |
0.435 |
|
| 1990 |
Bondy CA, Werner H, Roberts CT, LeRoith D. Cellular pattern of insulin-like growth factor-I (IGF-I) and type I IGF receptor gene expression in early organogenesis: comparison with IGF-II gene expression. Molecular Endocrinology (Baltimore, Md.). 4: 1386-98. PMID 2172801 DOI: 10.1210/Mend-4-9-1386 |
0.47 |
|
| 1990 |
Werner H, Stannard B, Bach MA, LeRoith D, Roberts CT. Cloning and characterization of the proximal promoter region of the rat insulin-like growth factor I (IGF-I) receptor gene. Biochemical and Biophysical Research Communications. 169: 1021-7. PMID 2163625 DOI: 10.1016/0006-291X(90)91996-6 |
0.362 |
|
| 1990 |
Magri KA, Adamo M, Leroith D, Etherton TD. The inhibition of insulin action and glucose metabolism by porcine growth hormone in porcine adipocytes is not the result of any decrease in insulin binding or insulin receptor kinase activity. The Biochemical Journal. 266: 107-13. PMID 2155602 DOI: 10.1042/Bj2660107 |
0.707 |
|
| 1990 |
Jansson JO, Carlsson L, Ekberg S, Isgaard J, Carlsson B, Billig H, Leroith D, Roberts CT, Adamo M, Woloschak M. Pulsatile growth hormone secretory pattern: autofeedback regulation and effects on growth factors. Acta Paediatrica Scandinavica. Supplement. 367: 98-102. PMID 1977279 DOI: 10.1111/J.1651-2227.1990.Tb11642.X |
0.596 |
|
| 1989 |
Adamo M, LeRoith D, Simon J, Roth J. Effect of altered nutritional states on insulin receptors. Annual Review of Nutrition. 8: 149-66. PMID 3060162 DOI: 10.1146/Annurev.Nu.08.070188.001053 |
0.687 |
|
| 1989 |
Fagin JA, Roberts CT, LeRoith D, Brown AT. Coordinate decrease of tissue insulinlike growth factor I posttranscriptional alternative mRNA transcripts in diabetes mellitus. Diabetes. 38: 428-34. PMID 2925006 DOI: 10.2337/Diab.38.4.428 |
0.365 |
|
| 1989 |
Roberts CT, Leroith D. Molecular aspects of insulin-like growth factors, their binding proteins and receptors. Bailliere's Clinical Endocrinology and Metabolism. 2: 1069-85. PMID 2855823 DOI: 10.1016/S0950-351X(88)80030-2 |
0.463 |
|
| 1989 |
Ota A, Shen-Orr Z, Roberts CT, LeRoith D. TPA-induced neurite formation in a neuroblastoma cell line (SH-SY5Y) is associated with increased IGF-I receptor mRNA and binding. Brain Research. Molecular Brain Research. 6: 69-76. PMID 2770453 DOI: 10.1016/0169-328X(89)90030-2 |
0.381 |
|
| 1989 |
Lowe WL, Adamo M, LeRoith D, Roberts CT. Expression and stability of insulin-like growth factor-I (IGF-I) mRNA splicing variants in the GH3 rat pituitary cell line. Biochemical and Biophysical Research Communications. 162: 1174-9. PMID 2764927 DOI: 10.1016/0006-291X(89)90797-3 |
0.663 |
|
| 1989 |
Hernandez ER, Roberts CT, LeRoith D, Adashi EY. Rat ovarian insulin-like growth factor I (IGF-I) gene expression is granulosa cell-selective: 5'-untranslated mRNA variant representation and hormonal regulation. Endocrinology. 125: 572-4. PMID 2737167 DOI: 10.1210/Endo-125-1-572 |
0.448 |
|
| 1989 |
Adamo M, Lowe WL, LeRoith D, Roberts CT. Insulin-like growth factor I messenger ribonucleic acids with alternative 5'-untranslated regions are differentially expressed during development of the rat. Endocrinology. 124: 2737-44. PMID 2721444 DOI: 10.1210/Endo-124-6-2737 |
0.67 |
|
| 1989 |
Werner H, Adamo M, Lowe WL, Roberts CT, LeRoith D. Developmental regulation of rat brain/Hep G2 glucose transporter gene expression. Molecular Endocrinology (Baltimore, Md.). 3: 273-9. PMID 2710134 DOI: 10.1210/Mend-3-2-273 |
0.612 |
|
| 1989 |
Werner H, Raizada MK, Mudd LM, Foyt HL, Simpson IA, Roberts CT, LeRoith D. Regulation of rat brain/HepG2 glucose transporter gene expression by insulin and insulin-like growth factor-I in primary cultures of neuronal and glial cells Endocrinology. 125: 314-320. PMID 2661208 DOI: 10.1210/Endo-125-1-314 |
0.445 |
|
| 1989 |
Lowe WL, Roberts CT, LeRoith D, Rojeski MT, Merimee TJ, Fui ST, Keen H, Arnold D, Mersey J, Gluzman S. Insulin-like growth factor-II in nonislet cell tumors associated with hypoglycemia: increased levels of messenger ribonucleic acid. The Journal of Clinical Endocrinology and Metabolism. 69: 1153-9. PMID 2584352 DOI: 10.1210/Jcem-69-6-1153 |
0.395 |
|
| 1989 |
Adamo M, Raizada MK, LeRoith D. Insulin and insulin-like growth factor receptors in the nervous system. Molecular Neurobiology. 3: 71-100. PMID 2553069 DOI: 10.1007/Bf02935589 |
0.71 |
|
| 1989 |
Draznin B, Lewis D, Houlder N, Sherman N, Adamo M, Garvey WT, LeRoith D, Sussman K. Mechanism of insulin resistance induced by sustained levels of cytosolic free calcium in rat adipocytes Endocrinology. 125: 2341-2349. PMID 2551647 DOI: 10.1210/Endo-125-5-2341 |
0.664 |
|
| 1989 |
Lowe WL, Adamo M, Werner H, Roberts CT, LeRoith D. Regulation by fasting of rat insulin-like growth factor I and its receptor. Effects on gene expression and binding. The Journal of Clinical Investigation. 84: 619-26. PMID 2547834 DOI: 10.1172/Jci114207 |
0.706 |
|
| 1989 |
Adamo M, Shemer J, Aridor M, Dixon J, Carswell N, Bhathena SJ, Michaelis OE, LeRoith D. Liver insulin receptor tyrosine kinase activity in a rat model of type II diabetes mellitus and obesity. The Journal of Nutrition. 119: 484-9. PMID 2537893 DOI: 10.1093/Jn/119.3.484 |
0.697 |
|
| 1989 |
Zilberstein M, Chou JY, Lowe WL, Shen-Orr Z, Roberts CT, LeRoith D, Catt KJ. Expression of insulin-like growth factor-I and its receptor by SV40-transformed rat granulosa cells. Molecular Endocrinology (Baltimore, Md.). 3: 1488-97. PMID 2481820 DOI: 10.1210/Mend-3-9-1488 |
0.425 |
|
| 1989 |
Werner H, Woloschak M, Adamo M, Shen-Orr Z, Roberts CT, LeRoith D. Developmental regulation of the rat insulin-like growth factor I receptor gene. Proceedings of the National Academy of Sciences of the United States of America. 86: 7451-5. PMID 2477843 DOI: 10.1073/Pnas.86.19.7451 |
0.707 |
|
| 1989 |
Shemer J, Adamo M, Raizada MK, Heffez D, Zick Y, LeRoith D. Insulin and IGF-I stimulate phosphorylation of their respective receptors in intact neuronal and glial cells in primary culture Journal of Molecular Neuroscience. 1: 137-137. DOI: 10.1007/BF02918899 |
0.651 |
|
| 1989 |
Shemer J, Adamo M, Raizada MK, Heffez D, Zick Y, LeRoith D. Insulin and IGF-I stimulate phosphorylation of their respective receptors in intact neuronal and glial cells in primary culture Journal of Molecular Neuroscience. 1: 137. DOI: 10.1007/BF02896897 |
0.651 |
|
| 1988 |
Lowe WL, Roberts CT, Lasky SR, LeRoith D. Differential expression of alternative 5' untranslated regions in mRNAs encoding rat insulin-like growth factor I. Proceedings of the National Academy of Sciences of the United States of America. 84: 8946-50. PMID 3480521 DOI: 10.1073/Pnas.84.24.8946 |
0.404 |
|
| 1988 |
Roberts CT, Lasky SR, Lowe WL, Seaman WT, LeRoith D. Molecular cloning of rat insulin-like growth factor I complementary deoxyribonucleic acids: differential messenger ribonucleic acid processing and regulation by growth hormone in extrahepatic tissues. Molecular Endocrinology (Baltimore, Md.). 1: 243-8. PMID 3453891 DOI: 10.1210/Mend-1-3-243 |
0.433 |
|
| 1988 |
Adamo M, Simon J, Rosebrough RW, McMurtry JP, Steele NC, LeRoith D. Characterization of the chicken muscle insulin receptor. General and Comparative Endocrinology. 68: 456-65. PMID 3436519 DOI: 10.1016/0016-6480(87)90085-2 |
0.7 |
|
| 1988 |
Lowe WL, Lasky SR, LeRoith D, Roberts CT. Distribution and regulation of rat insulin-like growth factor I messenger ribonucleic acids encoding alternative carboxyterminal E-peptides: evidence for differential processing and regulation in liver. Molecular Endocrinology (Baltimore, Md.). 2: 528-35. PMID 3419435 DOI: 10.1210/Mend-2-6-528 |
0.437 |
|
| 1988 |
Ota A, Shemer J, Pruss RM, Lowe WL, LeRoith D. Characterization of the altered oligosaccharide composition of the insulin receptor on neural-derived cells. Brain Research. 443: 1-11. PMID 3359262 DOI: 10.1016/0006-8993(88)91592-2 |
0.443 |
|
| 1988 |
Raizada MK, Shemer J, Judkins JH, Clarke DW, Masters BA, LeRoith D. Insulin receptors in the brain: Structural and physiological characterization Neurochemical Research. 13: 297-303. PMID 3292965 DOI: 10.1007/Bf00972477 |
0.485 |
|
| 1988 |
LeRoith D, Lowe WL, Shemer J, Raizada MK, Ota A. Development of brain insulin receptors. The International Journal of Biochemistry. 20: 225-30. PMID 3281864 DOI: 10.1016/0020-711X(88)90345-X |
0.429 |
|
| 1988 |
Rodrigues M, Waldbillig RJ, Rajagopalan S, Hackett J, LeRoith D, Chader GJ. Retinal insulin receptors: localization using a polyclonal anti-insulin receptor antibody. Brain Research. 443: 389-94. PMID 3129136 DOI: 10.1016/0006-8993(88)91639-3 |
0.406 |
|
| 1988 |
LeRoith D, Adamo M, Shemer J, Waldbillig R, Lesniak MA, DePablo F, Hart C, Roth J. Insulin-related materials in the nervous system of vertebrates and non-vertebrates: Possible extrapancreatic production Hormone and Metabolic Research. 20: 411-420. PMID 3049289 DOI: 10.1055/S-2007-1010850 |
0.682 |
|
| 1988 |
Ota A, Wilson GL, LeRoith D. Insulin-like growth factor I receptors on mouse neuroblastoma cells. Two β subunits are derived from differences in glycosylation European Journal of Biochemistry. 174: 521-530. PMID 2968905 DOI: 10.1111/J.1432-1033.1988.Tb14130.X |
0.434 |
|
| 1988 |
Ota A, Wilson GL, Spilberg O, Pruss R, LeRoith D. Functional insulin-like growth factor I receptors are expressed by neural-derived continuous cell lines. Endocrinology. 122: 145-52. PMID 2961554 DOI: 10.1210/Endo-122-1-145 |
0.412 |
|
| 1988 |
Shemer J, Ota A, Adamo M, LeRoith D. Insulin-sensitive tyrosine kinase is increased in livers of adult obese Zucker rats: correction with prolonged fasting. Endocrinology. 123: 140-8. PMID 2838251 DOI: 10.1210/Endo-123-1-140 |
0.693 |
|
| 1988 |
Adamo M, Werner H, Farnsworth W, Roberts CT, Raizada M, LeRoith D. Dexamethasone reduces steady state insulin-like growth factor I messenger ribonucleic acid levels in rat neuronal and glial cells in primary culture. Endocrinology. 123: 2565-70. PMID 2458916 DOI: 10.1210/Endo-123-5-2565 |
0.673 |
|
| 1987 |
Roberts CT, Lasky SR, Lowe WL, LeRoith D. Rat IGF-I cDNA's contain multiple 5'-untranslated regions. Biochemical and Biophysical Research Communications. 146: 1154-9. PMID 3619921 DOI: 10.1016/0006-291X(87)90768-6 |
0.335 |
|
| 1987 |
Shemer J, LeRoith D. The interaction of brain insulin receptors with wheat germ agglutinin. Neuropeptides. 9: 1-8. PMID 3561720 DOI: 10.1016/0143-4179(87)90025-4 |
0.409 |
|
| 1987 |
Waldbillig RJ, LeRoith D. Insulin receptors in the peripheral nervous system: a structural and functional analysis. Brain Research. 409: 215-20. PMID 3555703 DOI: 10.1016/0006-8993(87)90704-9 |
0.466 |
|
| 1987 |
Hart C, Shemer J, Penhos JC, Lesniak MA, Roth J, LeRoith D. Frog brain and liver show evolutionary conservation of tissue-specific differences among insulin receptors General and Comparative Endocrinology. 68: 170-178. PMID 3322930 DOI: 10.1016/0016-6480(87)90026-8 |
0.443 |
|
| 1987 |
Waldbillig RJ, Fletcher RT, Chader GJ, Rajagopalan S, Rodrigues M, LeRoith D. Retinal insulin receptors. 2. Characterization and insulin-induced tyrosine kinase activity in bovine retinal rod outer segments. Experimental Eye Research. 45: 837-44. PMID 3322853 DOI: 10.1016/S0014-4835(87)80100-8 |
0.449 |
|
| 1987 |
Waldbillig RJ, Fletcher RT, Chader GJ, Rajagopalan S, Rodrigues M, LeRoith D. Retinal insulin receptors. 1. Structural heterogeneity and functional characterization. Experimental Eye Research. 45: 823-35. PMID 3123267 DOI: 10.1016/S0014-4835(87)80099-4 |
0.332 |
|
| 1986 |
Simon J, Leroith D. Insulin receptors of chicken liver and brain. Characterization of alpha and beta subunit properties. European Journal of Biochemistry. 158: 125-32. PMID 3525156 DOI: 10.1111/J.1432-1033.1986.Tb09729.X |
0.448 |
|
| 1986 |
Shemer J, Penhos JC, LeRoith D. Insulin receptors in lizard brain and liver: structural and functional studies of alpha and beta subunits demonstrate evolutionary conservation. Diabetologia. 29: 321-329. PMID 3522330 DOI: 10.1007/Bf00452070 |
0.454 |
|
| 1986 |
Lowe WL, Boyd FT, Clarke DW, Raizada MK, Hart C, LeRoith D. Development of brain insulin receptors: structural and functional studies of insulin receptors from whole brain and primary cell cultures. Endocrinology. 119: 25-35. PMID 3522210 DOI: 10.1210/Endo-119-1-25 |
0.391 |
|
| 1986 |
de Pablo F, Lesniak MA, Hernandez ER, LeRoith D, Shiloach J, Roth J. Extracts of protozoa contain materials that react specifically in the immunoassay for guinea pig insulin Hormone and Metabolic Research. 18: 82-87. PMID 3084369 DOI: 10.1055/S-2007-1012237 |
0.422 |
|
| 1986 |
Lowe W, LeRoith D. Insulin receptors from guinea pig liver and brain: structural and functional studies. Endocrinology. 118: 1669-77. PMID 3081332 DOI: 10.1210/Endo-118-4-1669 |
0.406 |
|
| 1986 |
Lowe WL, LeRoith D. Tyrosine kinase activity of brain insulin and IGF-1 receptors. Biochemical and Biophysical Research Communications. 134: 532-8. PMID 3004453 DOI: 10.1016/S0006-291X(86)80453-3 |
0.456 |
|
| 1985 |
LeRoith D, Shiloach J, Heffron R, Rubinovitz C, Tanenbaum R, Roth J. Insulin-related material in microbes: Similarities and differences from mammalian insulins Canadian Journal of Biochemistry and Cell Biology. 63: 839-849. PMID 3933801 DOI: 10.1139/o85-106 |
0.339 |
|
| 1985 |
Rosenzweig JL, LeRoith D, Lesniak MA, Yip CC, Orth DN, Nankin HR, Murone P, Berelowitz M, Frohman LA, Liotta AS, Krieger DT, Roth J. Two distinct insulin-related molecules in the guinea pig: immunological and biochemical characterization of insulin-like immunoactivity from extrapancreatic tissues of the guinea pig Diabetologia. 28: 237-243. PMID 3894136 DOI: 10.1007/Bf00282240 |
0.418 |
|
| 1981 |
LeRoith D, Lesniak MA, Roth J. Insulin in insects and annelids Diabetes. 30: 70-76. PMID 6785127 DOI: 10.2337/Diab.30.1.70 |
0.449 |
|
| 1977 |
Pimstone B, Epstein S, Hamilton SM, LeRoith D, Hendricks S. Metabolic clearance and plasma half disappearance time of exogenous gonadotropin releasing hormone in normal subjects and in patients with liver disease and chronic renal failure. The Journal of Clinical Endocrinology and Metabolism. 44: 356-60. PMID 320223 DOI: 10.1210/Jcem-44-2-356 |
0.536 |
|
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