David Brigstock - Publications

Affiliations: 
Ohio State University, Columbus, Columbus, OH 
Area:
Molecular Biology

73 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Sun L, Qu L, Brigstock DR, Li H, Li Y, Gao R. Biological and Proteomic Characteristics of an Immortalized Human Pancreatic Stellate Cell Line. International Journal of Medical Sciences. 17: 137-144. PMID 31929747 DOI: 10.7150/ijms.36337  0.367
2018 Chen L, Chen R, Kemper S, Cong M, You H, Brigstock DR. Therapeutic effects of serum extracellular vesicles in liver fibrosis. Journal of Extracellular Vesicles. 7: 1461505. PMID 29696080 DOI: 10.1080/20013078.2018.1461505  0.339
2017 Chen L, Chen R, Kemper S, Brigstock DR. Pathways of production and delivery of hepatocyte exosomes. Journal of Cell Communication and Signaling. PMID 29063370 DOI: 10.1007/s12079-017-0421-7  0.323
2017 Chen L, Brigstock DR. Cellular or Exosomal microRNAs Associated with CCN Gene Expression in Liver Fibrosis. Methods in Molecular Biology (Clifton, N.J.). 1489: 465-480. PMID 27734397 DOI: 10.1007/978-1-4939-6430-7_38  0.352
2017 Chen L, Brigstock DR. Analysis of Pathological Activities of CCN Proteins in Fibrotic Diseases: Liver Fibrosis. Methods in Molecular Biology (Clifton, N.J.). 1489: 445-463. PMID 27734396 DOI: 10.1007/978-1-4939-6430-7_37  0.315
2016 Chen L, Brigstock DR. Integrins and heparan sulfate proteoglycans on hepatic stellate cells (HSC) are novel receptors for HSC-derived exosomes. Febs Letters. PMID 27714787 DOI: 10.1002/1873-3468.12448  0.32
2015 Chen L, Chen R, Kemper S, Charrier A, Brigstock DR. Suppression of fibrogenic signaling in hepatic stellate cells by Twist1-dependent microRNA-214 expression: Role of exosomes in horizontal transfer of Twist1. American Journal of Physiology. Gastrointestinal and Liver Physiology. ajpgi.00140.2015. PMID 26229009 DOI: 10.1152/Ajpgi.00140.2015  0.778
2014 Charrier A, Chen R, Chen L, Kemper S, Hattori T, Takigawa M, Brigstock DR. Exosomes mediate intercellular transfer of pro-fibrogenic connective tissue growth factor (CCN2) between hepatic stellate cells, the principal fibrotic cells in the liver. Surgery. 156: 548-55. PMID 24882759 DOI: 10.1016/J.Surg.2014.04.014  0.794
2014 Charrier A, Chen R, Kemper S, Brigstock DR. Regulation of pancreatic inflammation by connective tissue growth factor (CTGF/CCN2). Immunology. 141: 564-76. PMID 24754049 DOI: 10.1111/Imm.12215  0.772
2014 Cheung LC, Strickland DH, Howlett M, Ford J, Charles AK, Lyons KM, Brigstock DR, Goldschmeding R, Cole CH, Alexander WS, Kees UR. Connective tissue growth factor is expressed in bone marrow stromal cells and promotes interleukin-7-dependent B lymphopoiesis. Haematologica. 99: 1149-56. PMID 24727816 DOI: 10.3324/Haematol.2013.102327  0.346
2014 Charrier A, Chen R, Chen L, Kemper S, Hattori T, Takigawa M, Brigstock DR. Connective tissue growth factor (CCN2) and microRNA-21 are components of a positive feedback loop in pancreatic stellate cells (PSC) during chronic pancreatitis and are exported in PSC-derived exosomes. Journal of Cell Communication and Signaling. 8: 147-56. PMID 24464300 DOI: 10.1007/S12079-014-0220-3  0.767
2014 Chen L, Charrier A, Zhou Y, Chen R, Yu B, Agarwal K, Tsukamoto H, Lee LJ, Paulaitis ME, Brigstock DR. Epigenetic regulation of connective tissue growth factor by MicroRNA-214 delivery in exosomes from mouse or human hepatic stellate cells. Hepatology (Baltimore, Md.). 59: 1118-29. PMID 24122827 DOI: 10.1002/Hep.26768  0.755
2014 Charrier A, Chen L, Chen R, Hattori T, Takigawa M, Brigstock D. Production of Nano-Sized Exosomes by Fibrogenic Cells of the Liver or Pancreas: Role in Intercellular Delivery of Pro-Fibrotic Molecules and Potential as Novel Drug Delivery Agents In Vivo Journal of Surgical Research. 186: 678. DOI: 10.1016/J.Jss.2013.11.871  0.339
2013 Abbott RD, Purmessur D, Monsey RD, Brigstock DR, Laudier DM, Iatridis JC. Degenerative grade affects the responses of human nucleus pulposus cells to Link-N, CTGF, and TGFβ3 Journal of Spinal Disorders and Techniques. 26: E86-E94. PMID 22907063 DOI: 10.1097/Bsd.0B013E31826E0Ca4  0.363
2013 Charrier A, Brigstock DR. Regulation of pancreatic function by connective tissue growth factor (CTGF, CCN2). Cytokine & Growth Factor Reviews. 24: 59-68. PMID 22884427 DOI: 10.1016/J.Cytogfr.2012.07.001  0.799
2013 Charrier A, Brigstock D. A Novel Biological Role for Connective Tissue Growth Factor (CTGF): Modulation of Inflammatory Cell Recruitment During Alcohol-Induced Injury of the Pancreas Journal of Surgical Research. 179: 232. DOI: 10.1016/j.jss.2012.10.426  0.337
2012 Xiu M, Liu YH, Brigstock DR, He FH, Zhang RJ, Gao RP. Connective tissue growth factor is overexpressed in human hepatocellular carcinoma and promotes cell invasion and growth. World Journal of Gastroenterology. 18: 7070-8. PMID 23323010 DOI: 10.3748/wjg.v18.i47.7070  0.316
2012 Nagaraja T, Chen L, Balasubramanian A, Groopman JE, Ghoshal K, Jacob ST, Leask A, Brigstock DR, Anand AR, Ganju RK. Activation of the connective tissue growth factor (CTGF)-transforming growth factor β 1 (TGF-β 1) axis in hepatitis C virus-expressing hepatocytes. Plos One. 7: e46526. PMID 23056332 DOI: 10.1371/Journal.Pone.0046526  0.311
2012 Huang G, Brigstock DR. Regulation of hepatic stellate cells by connective tissue growth factor. Frontiers in Bioscience (Landmark Edition). 17: 2495-507. PMID 22652794  0.44
2012 Huang G, Besner GE, Brigstock DR. Heparin-binding epidermal growth factor-like growth factor suppresses experimental liver fibrosis in mice. Laboratory Investigation; a Journal of Technical Methods and Pathology. 92: 703-12. PMID 22330337 DOI: 10.1038/Labinvest.2012.3  0.337
2012 Charrier A, Brigstock D. Tu1495 Connective Tissue Growth Factor Production by Pancreatic Acinar Cells is Associated With Regulation of Immune Function in a Mouse Model of Alcoholic Chronic Pancreatitis Gastroenterology. 142: S-848-S-849. DOI: 10.1016/S0016-5085(12)63289-2  0.788
2012 Chen L, Charrier A, Zhou Y, Brigstock D. The Pro-Fibrotic Molecule, Connective Tissue Growth Factor (CTGF), is Regulated by MicroRNA-214 (miR-214) in Hepatic Stellate Cells Journal of Surgical Research. 172: 205. DOI: 10.1016/j.jss.2011.11.281  0.365
2011 Chen L, Charrier AL, Leask A, French SW, Brigstock DR. Ethanol-stimulated differentiated functions of human or mouse hepatic stellate cells are mediated by connective tissue growth factor. Journal of Hepatology. 55: 399-406. PMID 21156189 DOI: 10.1016/J.Jhep.2010.11.025  0.8
2011 Huang G, Brigstock DR. Integrin expression and function in the response of primary culture hepatic stellate cells to connective tissue growth factor (CCN2). Journal of Cellular and Molecular Medicine. 15: 1087-95. PMID 20406330 DOI: 10.1111/j.1582-4934.2010.01072.x  0.311
2011 Chen L, Tsukamoto H, Brigstock D. Ethanol-Dependent Expression of Connective Tissue Growth Factor is Associated With Down-Regulation of MicroRNA 214 Gastroenterology. 140: S-916. DOI: 10.1016/S0016-5085(11)63799-2  0.446
2010 Charrier AL, Brigstock DR. Connective tissue growth factor production by activated pancreatic stellate cells in mouse alcoholic chronic pancreatitis. Laboratory Investigation; a Journal of Technical Methods and Pathology. 90: 1179-88. PMID 20368699 DOI: 10.1038/Labinvest.2010.82  0.778
2009 Gao RP, Brigstock DR. Connective tissue growth factor hammerhead ribozyme attenuates human hepatic stellate cell function. World Journal of Gastroenterology. 15: 3807-13. PMID 19673024  0.406
2009 Tong Z, Chen R, Alt DS, Kemper S, Perbal B, Brigstock DR. Susceptibility to liver fibrosis in mice expressing a connective tissue growth factor transgene in hepatocytes. Hepatology (Baltimore, Md.). 50: 939-47. PMID 19670427 DOI: 10.1002/hep.23102  0.331
2009 Zhou Y, Brigstock D, Besner GE. Heparin-binding EGF-like growth factor is a potent dilator of terminal mesenteric arterioles. Microvascular Research. 78: 78-85. PMID 19389413 DOI: 10.1016/J.Mvr.2009.04.006  0.35
2009 Wang J, Leclercq I, Brymora JM, Xu N, Ramezani-Moghadam M, London RM, Brigstock D, George J. Kupffer cells mediate leptin-induced liver fibrosis. Gastroenterology. 137: 713-23. PMID 19375424 DOI: 10.1053/J.Gastro.2009.04.011  0.372
2009 Brigstock DR. Strategies for blocking the fibrogenic actions of connective tissue growth factor (CCN2): From pharmacological inhibition in vitro to targeted siRNA therapy in vivo. Journal of Cell Communication and Signaling. 3: 5-18. PMID 19294531 DOI: 10.1007/s12079-009-0043-9  0.313
2009 Lawrencia C, Charrier A, Huang G, Brigstock DR. Ethanol-mediated expression of connective tissue growth factor (CCN2) in mouse pancreatic stellate cells. Growth Factors (Chur, Switzerland). 27: 91-9. PMID 19280452 DOI: 10.1080/08977190902786319  0.767
2009 Crawford LA, Guney MA, Oh YA, Deyoung RA, Valenzuela DM, Murphy AJ, Yancopoulos GD, Lyons KM, Brigstock DR, Economides A, Gannon M. Connective tissue growth factor (CTGF) inactivation leads to defects in islet cell lineage allocation and beta-cell proliferation during embryogenesis. Molecular Endocrinology (Baltimore, Md.). 23: 324-36. PMID 19131512 DOI: 10.1210/me.2008-0045  0.386
2009 Huang G, Brigstock D. S1606 Integrin α5β1 Is a CTGF Receptor On Early Primary Culture Hepatic Stellate Cells and Interacts with Fibronectin and Heparan Sulfate Proteglycans to Regulate CTGF Function Gastroenterology. 136: A-823. DOI: 10.1016/S0016-5085(09)63796-3  0.367
2009 Huang G, Brigstock D. S1601 Differential Modulation of Integrins Gene Expression By Connective Tissue Growth Factor in Early and Activated Primary Culture Hepatic Stellate Cells Gastroenterology. 136: A-822. DOI: 10.1016/S0016-5085(09)63791-4  0.49
2008 Leask A, Chen S, Pala D, Brigstock DR. Regulation of CCN2 mRNA expression and promoter activity in activated hepatic stellate cells. Journal of Cell Communication and Signaling. 2: 49-56. PMID 18798011 DOI: 10.1007/s12079-008-0029-z  0.363
2008 Lawrencia C, Brigstock D. 363 Selective Targeting of CTGF SIRNA to Activated Stellate Cells Reduces Carbon Tetrachloride (Ccl4) Induced Hepatic Fibrosis In Vivo Gastroenterology. 134: A-764. DOI: 10.1016/S0016-5085(08)63569-6  0.334
2006 Tong ZY, Brigstock DR. Intrinsic biological activity of the thrombospondin structural homology repeat in connective tissue growth factor. The Journal of Endocrinology. 188: R1-8. PMID 16522717 DOI: 10.1677/joe.1.06719  0.41
2006 Gao R, Brigstock DR. A novel integrin α5β1 binding domain in module 4 of connective tissue growth factor (CCN2/CTGF) promotes adhesion and migration of activated pancreatic stellate cells Gut. 55: 856-862. PMID 16361307 DOI: 10.1136/gut.2005.079178  0.386
2005 Gao R, Brigstock DR. Activation of nuclear factor kappa B (NF-kappaB) by connective tissue growth factor (CCN2) is involved in sustaining the survival of primary rat hepatic stellate cells. Cell Communication and Signaling : Ccs. 3: 14. PMID 16303051 DOI: 10.1186/1478-811X-3-14  0.414
2005 Gao R, Brigstock DR. Connective tissue growth factor (CCN2) in rat pancreatic stellate cell function: integrin alpha5beta1 as a novel CCN2 receptor. Gastroenterology. 129: 1019-30. PMID 16143139 DOI: 10.1053/j.gastro.2005.06.067  0.417
2005 Cicha I, Yilmaz A, Klein M, Raithel D, Brigstock DR, Daniel WG, Goppelt-Struebe M, Garlichs CD. Connective tissue growth factor is overexpressed in complicated atherosclerotic plaques and induces mononuclear cell chemotaxis in vitro. Arteriosclerosis, Thrombosis, and Vascular Biology. 25: 1008-13. PMID 15761189 DOI: 10.1161/01.ATV.0000162173.27682.7b  0.426
2005 Rachfal AW, Brigstock DR. Structural and functional properties of CCN proteins. Vitamins and Hormones. 70: 69-103. PMID 15727802 DOI: 10.1016/S0083-6729(05)70003-0  0.791
2004 Gao R, Ball DK, Perbal B, Brigstock DR. Connective tissue growth factor induces c-fos gene activation and cell proliferation through p44/42 MAP kinase in primary rat hepatic stellate cells. Journal of Hepatology. 40: 431-8. PMID 15123357 DOI: 10.1016/J.Jhep.2003.11.012  0.812
2004 Wang JF, Olson ME, Ma L, Brigstock DR, Hart DA. Connective tissue growth factor siRNA modulates mRNA levels for a subset of molecules in normal and TGF-beta 1-stimulated porcine skin fibroblasts. Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society. 12: 205-16. PMID 15086772 DOI: 10.1111/j.1067-1927.2004.012113.x  0.316
2004 Rachfal AW, Luquette MH, Brigstock DR. Expression of connective tissue growth factor (CCN2) in desmoplastic small round cell tumour. Journal of Clinical Pathology. 57: 422-5. PMID 15047749  0.795
2003 Gao R, Brigstock DR. Low density lipoprotein receptor-related protein (LRP) is a heparin-dependent adhesion receptor for connective tissue growth factor (CTGF) in rat activated hepatic stellate cells. Hepatology Research : the Official Journal of the Japan Society of Hepatology. 27: 214-220. PMID 14585398  0.393
2003 Brigstock DR. The CCN family: a new stimulus package. The Journal of Endocrinology. 178: 169-75. PMID 12904165 DOI: 10.1677/JOE.0.1780169  0.368
2003 Rachfal AW, Brigstock DR. Connective tissue growth factor (CTGF/CCN2) in hepatic fibrosis. Hepatology Research : the Official Journal of the Japan Society of Hepatology. 26: 1-9. PMID 12787797 DOI: 10.1016/S1386-6346(03)00115-3  0.8
2003 Wang JF, Olson ME, Ball DK, Brigstock DR, Hart DA. Recombinant connective tissue growth factor modulates porcine skin fibroblast gene expression. Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society. 11: 220-9. PMID 12753604 DOI: 10.1046/J.1524-475X.2003.11311.X  0.799
2003 Ball DK, Moussad EE, Rageh MA, Kemper SA, Brigstock DR. Establishment of a recombinant expression system for connective tissue growth factor (CTGF) that models CTGF processing in utero. Reproduction (Cambridge, England). 125: 271-84. PMID 12578541  0.813
2003 Ball DK, Rachfal AW, Kemper SA, Brigstock DR. The heparin-binding 10 kDa fragment of connective tissue growth factor (CTGF) containing module 4 alone stimulates cell adhesion. The Journal of Endocrinology. 176: R1-7. PMID 12553878  0.757
2003 Gao R, Brigstock DR. Low density lipoprotein receptor-related protein (LRP) is a heparin-dependent adhesion receptor for connective tissue growth factor (CTGF) in rat activated hepatic stellate cells Hepatology Research. 27: 214-220. DOI: 10.1016/S1386-6346(03)00241-9  0.387
2003 GAO R, BRIGSTOCK D. 1270 Connective tissue growth factor (CTGF) induces adhesion of rat activated hepatic stellate cells via integrin alpha V beta 3 and heparan sulfate proteoglycans through its carboxyl-terminal domain Hepatology. 38: 772-772. DOI: 10.1016/S0270-9139(03)81308-3  0.325
2002 Brigstock DR. Regulation of angiogenesis and endothelial cell function by connective tissue growth factor (CTGF) and cysteine-rich 61 (CYR61). Angiogenesis. 5: 153-65. PMID 12831056  0.426
2002 Koliopanos A, Friess H, di Mola FF, Tang WH, Kubulus D, Brigstock D, Zimmermann A, Büchler MW. Connective tissue growth factor gene expression alters tumor progression in esophageal cancer. World Journal of Surgery. 26: 420-7. PMID 11910473 DOI: 10.1007/S00268-001-0242-X  0.381
2002 di Mola FF, Friess H, Riesle E, Koliopanos A, Büchler P, Zhu Z, Brigstock DR, Korc M, Büchler MW. Connective tissue growth factor is involved in pancreatic repair and tissue remodeling in human and rat acute necrotizing pancreatitis. Annals of Surgery. 235: 60-7. PMID 11753043 DOI: 10.1097/00000658-200201000-00008  0.324
2001 Rageh MA, Moussad EE, Wilson AK, Brigstock DR. Steroidal regulation of connective tissue growth factor (CCN2; CTGF) synthesis in the mouse uterus. Molecular Pathology : Mp. 54: 338-46. PMID 11577177 DOI: 10.1136/mp.54.5.338  0.339
2000 Uzumcu M, Homsi MF, Ball DK, Coskun S, Jaroudi K, Hollanders JM, Brigstock DR. Localization of connective tissue growth factor in human uterine tissues. Molecular Human Reproduction. 6: 1093-8. PMID 11101692  0.798
2000 Moussad EE, Brigstock DR. Connective tissue growth factor: what's in a name? Molecular Genetics and Metabolism. 71: 276-92. PMID 11001822 DOI: 10.1006/MGME.2000.3059  0.415
2000 Williams EJ, Gaça MD, Brigstock DR, Arthur MJ, Benyon RC. Increased expression of connective tissue growth factor in fibrotic human liver and in activated hepatic stellate cells. Journal of Hepatology. 32: 754-61. PMID 10845662 DOI: 10.1016/S0168-8278(00)80244-5  0.409
2000 Harding PA, Surveyor GA, Brigstock DR. Characterization of pig connective tissue growth factor (CTGF) cDNA, mRNA and protein from uterine tissue. Dna Sequence : the Journal of Dna Sequencing and Mapping. 8: 385-90. PMID 10728823 DOI: 10.3109/10425179809020899  0.363
2000 Surveyor GA, Brigstock DR. Immunohistochemical localization of connective tissue growth factor (CTGF) in the mouse embryo between days 7.5 and 14.5 of gestation. Growth Factors (Chur, Switzerland). 17: 115-24. PMID 10595311 DOI: 10.3109/08977199909103520  0.402
1999 Harding PA, Davis-Fleischer KM, Crissman-Combs MA, Miller MT, Brigstock DR, Besner GE. Induction of anchorage independent growth by heparin-binding EGF-like growth factor (HB-EGF). Growth Factors (Chur, Switzerland). 17: 49-61. PMID 10495962 DOI: 10.3109/08977199909001062  0.394
1998 Surveyor GA, Wilson AK, Brigstock DR. Localization of connective tissue growth factor during the period of embryo implantation in the mouse. Biology of Reproduction. 59: 1207-13. PMID 9780329 DOI: 10.1095/BIOLREPROD59.5.1207  0.309
1998 Ball DK, Surveyor GA, Diehl JR, Steffen CL, Uzumcu M, Mirando MA, Brigstock DR. Characterization of 16- to 20-kilodalton (kDa) connective tissue growth factors (CTGFs) and demonstration of proteolytic activity for 38-kDa CTGF in pig uterine luminal flushings. Biology of Reproduction. 59: 828-35. PMID 9746732 DOI: 10.1095/Biolreprod59.4.828  0.787
1998 Steffen CL, Ball-Mirth DK, Harding PA, Bhattacharyya N, Pillai S, Brigstock DR. Characterization of cell-associated and soluble forms of connective tissue growth factor (CTGF) produced by fibroblast cells in vitro Growth Factors. 15: 199-213. PMID 9570041 DOI: 10.3109/08977199809002117  0.351
1997 Downing MT, Brigstock DR, Luquette MH, Crissman-Combs M, Besner GE. Immunohistochemical localization of heparin-binding epidermal growth factor-like growth factor in normal skin and skin cancers Histochemical Journal. 29: 735-744. PMID 9429077 DOI: 10.1023/A:1026417202351  0.327
1997 Brigstock DR, Steffen CL, Kim GY, Vegunta RK, Diehl JR, Harding PA. Purification and characterization of novel heparin-binding growth factors in uterine secretory fluids. Identification as heparin-regulated Mr 10,000 forms of connective tissue growth factor. The Journal of Biological Chemistry. 272: 20275-82. PMID 9242708 DOI: 10.1074/jbc.272.32.20275  0.359
1996 Davis KM, Brigstock DR, Johnson PR, Crissman-Combs MA, McCarthy DW, Downing MT, Besner GE. Production of glycosylated heparin-binding EGF-like growth factor in HeLa cells using vaccinia virus Protein Expression and Purification. 8: 57-67. PMID 8812835 DOI: 10.1006/Prep.1996.0074  0.315
1992 Brigstock DR. Growth factors in the uterus: steroidal regulation and biological actions. Bailliere's Clinical Endocrinology and Metabolism. 5: 791-808. PMID 1755816 DOI: 10.1016/S0950-351X(10)80015-1  0.343
1990 Brigstock DR, Heap RB, Barker PJ, Brown KD. Purification and characterization of heparin-binding growth factors from porcine uterus Biochemical Journal. 266: 273-282. PMID 2310377 DOI: 10.1042/bj2660273  0.302
1989 Brigstock DR, Heap RB, Brown KD. Polypeptide growth factors in uterine tissues and secretions Journal of Reproduction and Fertility. 85: 747-758. PMID 2649663 DOI: 10.1530/jrf.0.0850747  0.341
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