| Year |
Citation |
Score |
| 2020 |
Subramani E, Radoul M, Najac C, Batsios G, Molloy AR, Hong D, Gillespie AM, Delos Santos R, Viswanath P, Costello JF, Pieper RO, Ronen SM. Glutamate is a non-invasive metabolic biomarker of IDH1 mutant glioma response to temozolomide treatment. Cancer Research. PMID 32958546 DOI: 10.1158/0008-5472.Can-20-1314 |
0.377 |
|
| 2020 |
Molloy AR, Najac C, Viswanath P, Lakhani A, Subramani E, Batsios G, Radoul M, Gillespie AM, Pieper RO, Ronen SM. MR-detectable metabolic biomarkers of response to mutant IDH inhibition in low-grade glioma. Theranostics. 10: 8757-8770. PMID 32754276 DOI: 10.7150/Thno.47317 |
0.353 |
|
| 2020 |
Ohba S, Johannessen TA, Chatla K, Yang X, Pieper RO, Mukherjee J. Phosphoglycerate Mutase 1 Activates DNA Damage Repair via Regulation of WIP1 Activity. Cell Reports. 31: 107518. PMID 32294440 DOI: 10.1016/J.Celrep.2020.03.082 |
0.44 |
|
| 2019 |
Batsios G, Viswanath P, Subramani E, Najac C, Gillespie AM, Santos RD, Molloy AR, Pieper RO, Ronen SM. PI3K/mTOR inhibition of IDH1 mutant glioma leads to reduced 2HG production that is associated with increased survival. Scientific Reports. 9: 10521. PMID 31324855 DOI: 10.1038/S41598-019-47021-X |
0.44 |
|
| 2019 |
Chen D, Xia S, Wang M, Lin R, Li Y, Mao H, Aguiar M, Famulare CA, Shih AH, Brennan CW, Gao X, Pan Y, Liu S, Fan J, Jin L, ... ... Pieper RO, et al. Mutant and wild-type isocitrate dehydrogenase 1 share enhancing mechanisms involving distinct tyrosine kinase cascades in cancer. Cancer Discovery. PMID 30862724 DOI: 10.1158/2159-8290.Cd-18-1040 |
0.358 |
|
| 2019 |
Subramani E, Najac C, Batsios G, Viswanath P, Radoul M, Gillespie AM, Pieper RO, Ronen SM. Abstract 5263:1H and13C MRS-based metabolic markers of IDH1 mutant glioma response to temozolomide therapy Cancer Research. 79: 5263-5263. DOI: 10.1158/1538-7445.Am2019-5263 |
0.397 |
|
| 2019 |
Molloy A, Lakhani A, Najac C, Subramani E, Gillespie AM, Pieper RO, Viswanath P, Ronen S. Cbmt-10. Mutant Isocitrate Dehydrogenase 1 Inhibition Induces A Unique Mrs-Detectable Metabolic Signature In Low-Grade Gliomas Neuro-Oncology. 21. DOI: 10.1093/Neuonc/Noz175.132 |
0.36 |
|
| 2018 |
Radoul M, Najac C, Viswanath P, Mukherjee J, Kelly M, Gillespie AM, Chaumeil MM, Eriksson P, Delos Santos R, Pieper RO, Ronen SM. HDAC inhibition in glioblastoma monitored by hyperpolarized C MRSI. Nmr in Biomedicine. e4044. PMID 30561869 DOI: 10.1002/Nbm.4044 |
0.419 |
|
| 2018 |
Wood MD, Mukherjee J, Pieper RO. Neurofibromin knockdown in glioma cell lines is associated with changes in cytokine and chemokine secretion in vitro. Scientific Reports. 8: 5805. PMID 29643433 DOI: 10.1038/S41598-018-24046-2 |
0.388 |
|
| 2018 |
Viswanath P, Radoul M, Izquierdo-Garcia JL, Luchman HA, Gregory Cairncross J, Pieper RO, Phillips JJ, Ronen SM. Mutant IDH1 gliomas downregulate phosphocholine and phosphoethanolamine synthesis in a 2-hydroxyglutarate-dependent manner. Cancer & Metabolism. 6: 3. PMID 29619216 DOI: 10.1186/S40170-018-0178-3 |
0.353 |
|
| 2018 |
Mukherjee J, Johannessen TA, Ohba S, Chow TT, Jones LE, Pandita A, Pieper RO. Mutant IDH1 cooperates with ATRX loss to drive the alternative lengthening of telomere (ALT) phenotype in glioma. Cancer Research. PMID 29545335 DOI: 10.1158/0008-5472.Can-17-2269 |
0.441 |
|
| 2018 |
Viswanath P, Radoul M, Izquierdo-Garcia JL, Ong WQ, Luchman HA, Cairncross JG, Huang B, Pieper RO, Phillips JJ, Ronen SM. 2-hydroxyglutarate-mediated autophagy of the endoplasmic reticulum leads to an unusual downregulation of phospholipid biosynthesis in mutant IDH1 gliomas. Cancer Research. PMID 29358170 DOI: 10.1158/0008-5472.Can-17-2926 |
0.391 |
|
| 2018 |
Batsios G, Viswanath P, Gillespie AM, Subramani E, Phillips JJ, Pieper R, Ronen S. Exth-35. In Vivo 1H Mrs Detects Reduced 2Hg Production In Idh1 Mutant Gliomas Treated With A Dual Pi3K/Mtor Inhibitor Neuro-Oncology. 20. DOI: 10.1093/Neuonc/Noy148.384 |
0.334 |
|
| 2017 |
Viswanath P, Phillips JJ, Pieper RO, Ronen S. METB-11. HYPOXIA INDUCIBLE FACTOR 1α REPROGRAMS CHOLINE AND ETHANOLAMINE PHOSPHOLIPID METABOLISM IN MUTANT IDH1 GLIOMAS Neuro-Oncology. 19. DOI: 10.1093/Neuonc/Nox168.535 |
0.309 |
|
| 2017 |
Batsios G, Viswanath P, Phillips JJ, Pieper RO, Ronen S. EXTH-51. PI3K/mTOR INHIBITION LEADS TO REDUCTION IN 2HG PRODUCTION AND CELL PROLIFERATION IN IDH1 MUTANT CELLS. Neuro-Oncology. 19. DOI: 10.1093/Neuonc/Nox168.343 |
0.419 |
|
| 2016 |
Ohba S, Mukherjee J, Johannessen TC, Mancini A, Chow TT, Wood M, Jones L, Mazor T, Marshall RE, Viswanath P, Walsh KM, Perry A, Bell RJ, Phillips JJ, Costello JF, ... ... Pieper RO, et al. Mutant IDH1 expression drives TERT promoter reactivation as part of the cellular transformation process. Cancer Research. PMID 27758882 DOI: 10.1158/0008-5472.Can-16-0696 |
0.386 |
|
| 2016 |
Hu L, Li X, Liu Q, Xu J, Ge H, Wang Z, Wang H, Wang Z, Shi C, Xu X, Huang J, Lin Z, Pieper RO, Weng C. UBE2S, a novel substrate of Akt1, associates with Ku70 and regulates DNA repair and glioblastoma multiforme resistance to chemotherapy. Oncogene. PMID 27593939 DOI: 10.1038/Onc.2016.281 |
0.387 |
|
| 2016 |
Johannessen TA, Mukherjee J, Viswanath P, Ohba S, Ronen SM, Bjerkvig R, Pieper RO. Rapid Conversion of Mutant IDH1 from Driver to Passenger in a Model of Human Gliomagenesis. Molecular Cancer Research : McR. PMID 27430238 DOI: 10.1158/1541-7786.Mcr-16-0141 |
0.379 |
|
| 2016 |
Viswanath P, Najac C, Izquierdo-Garcia JL, Pankov A, Hong C, Eriksson P, Costello JF, Pieper RO, Ronen SM. Mutant IDH1 expression is associated with down-regulation of monocarboxylate transporters. Oncotarget. PMID 27144334 DOI: 10.18632/Oncotarget.9006 |
0.434 |
|
| 2016 |
Mukherjee J, Ohba S, See WL, Phillips JJ, Molinaro AM, Pieper RO. PKM2 uses control of HuR localization to regulate p27 and cell cycle progression in human glioblastoma cells. International Journal of Cancer. Journal International Du Cancer. PMID 26874904 DOI: 10.1002/Ijc.30041 |
0.401 |
|
| 2015 |
Izquierdo-Garcia JL, Viswanath P, Eriksson P, Cai L, Radoul M, Chaumeil MM, Blough M, Luchman HA, Weiss S, Cairncross JG, Phillips JJ, Pieper RO, Ronen SM. IDH1 Mutation Induces Reprogramming of Pyruvate Metabolism. Cancer Research. PMID 26045167 DOI: 10.1158/0008-5472.Can-15-0840 |
0.442 |
|
| 2015 |
Izquierdo-Garcia JL, Viswanath P, Eriksson P, Chaumeil MM, Pieper RO, Phillips JJ, Ronen SM. Metabolic reprogramming in mutant IDH1 glioma cells. Plos One. 10: e0118781. PMID 25706986 DOI: 10.1371/Journal.Pone.0118781 |
0.399 |
|
| 2015 |
Shelton S, Johnson B, Mazor T, Potts M, McDermott M, Huang E, Lim D, Pieper R, Berger M, Phillips J, Costello J, Oldham M. MPTH-29CONNECTING MUTANT GENOTYPES TO ABERRANT TRANSCRIPTIONAL SIGNATURES ACROSS SERIAL SECTIONS OF A HUMAN TUMOR Neuro-Oncology. 17: v144.4-v145. DOI: 10.1093/Neuonc/Nov222.29 |
0.374 |
|
| 2015 |
Viswanath P, Izquierdo-Garcia JL, Eriksson P, Cai L, Radoul M, Chaumeil MM, Blough M, Luchmann HA, Weiss S, Cairncross JG, Phillips JJ, Pieper RO, Ronen SM. Cbio-42Down Regulation Of Pyruvate Dehydrogenase Activity Is Essential For Cell Proliferation In Idh1 Mutant Glioma Cells. Neuro-Oncology. 17. DOI: 10.1093/Neuonc/Nov209.42 |
0.455 |
|
| 2015 |
Ohba S, Mukherjee J, Johannessen TA, Hirose Y, Chow T, Marshall R, Walsh K, Perry A, Phillips J, Ronen S, Pieper R. CBIO-32MUTANT IDH EXPRESSION DRIVES hTERT REACTIVATION AS PART OF THE CELLULAR TRANSFORMATION PROCESS Neuro-Oncology. 17: v61.3-v61. DOI: 10.1093/Neuonc/Nov209.32 |
0.38 |
|
| 2014 |
Park I, Mukherjee J, Ito M, Chaumeil MM, Jalbert LE, Gaensler K, Ronen SM, Nelson SJ, Pieper RO. Changes in pyruvate metabolism detected by magnetic resonance imaging are linked to DNA damage and serve as a sensor of temozolomide response in glioblastoma cells. Cancer Research. 74: 7115-24. PMID 25320009 DOI: 10.1158/0008-5472.Can-14-0849 |
0.421 |
|
| 2014 |
Izquierdo-Garcia JL, Cai LM, Chaumeil MM, Eriksson P, Robinson AE, Pieper RO, Phillips JJ, Ronen SM. Glioma cells with the IDH1 mutation modulate metabolic fractional flux through pyruvate carboxylase. Plos One. 9: e108289. PMID 25243911 DOI: 10.1371/Journal.Pone.0108289 |
0.419 |
|
| 2014 |
Ohba S, Mukherjee J, See WL, Pieper RO. Mutant IDH1-driven cellular transformation increases RAD51-mediated homologous recombination and temozolomide resistance. Cancer Research. 74: 4836-44. PMID 25035396 DOI: 10.1093/Neuonc/Nou245.3 |
0.427 |
|
| 2014 |
Chaumeil MM, Larson PE, Woods SM, Cai L, Eriksson P, Robinson AE, Lupo JM, Vigneron DB, Nelson SJ, Pieper RO, Phillips JJ, Ronen SM. Hyperpolarized [1-13C] glutamate: a metabolic imaging biomarker of IDH1 mutational status in glioma. Cancer Research. 74: 4247-57. PMID 24876103 DOI: 10.1093/Neuonc/Nou239.7 |
0.386 |
|
| 2014 |
Chesnelong C, Chaumeil MM, Blough MD, Al-Najjar M, Stechishin OD, Chan JA, Pieper RO, Ronen SM, Weiss S, Luchman HA, Cairncross JG. Lactate dehydrogenase A silencing in IDH mutant gliomas. Neuro-Oncology. 16: 686-95. PMID 24366912 DOI: 10.1093/Neuonc/Not243 |
0.436 |
|
| 2014 |
Izquierdo-Garcia J, Eriksson P, Cai L, Chaumeil M, Pieper R, Phillips J, Ronen S. Tm-0713C Mrs Detects Metabolic Flux Adaptation In Idh Mutant Glioma Cells Neuro-Oncology. 16. DOI: 10.1093/Neuonc/Nou278.7 |
0.404 |
|
| 2014 |
Mukherjee J, Obha S, Pieper R. CS-24PYRUVATE KINASE M2-MEDIATED SUBCELLULAR LOCALIZATION OF HuR REGULATES GLIOMA GROWTH. Neuro-Oncology. 16. DOI: 10.1093/Neuonc/Nou242.24 |
0.42 |
|
| 2014 |
Ronen SM, Izquierdo-Garcia JL, Chaumeil MM, Cai LM, Phillips JJ, Pieper RO. Metabolic Imaging Biomarkers For Mutant Idh1 Gliomas Neuro-Oncology. 16. DOI: 10.1093/Neuonc/Nou206.41 |
0.439 |
|
| 2013 |
Chaumeil MM, Larson PE, Yoshihara HA, Danforth OM, Vigneron DB, Nelson SJ, Pieper RO, Phillips JJ, Ronen SM. Non-invasive in vivo assessment of IDH1 mutational status in glioma. Nature Communications. 4: 2429. PMID 24019001 DOI: 10.1038/Ncomms3429 |
0.394 |
|
| 2013 |
Ito M, Ohba S, Gaensler K, Ronen SM, Mukherjee J, Pieper RO. Early Chk1 phosphorylation is driven by temozolomide-induced, DNA double strand break- and mismatch repair-independent DNA damage. Plos One. 8: e62351. PMID 23667469 DOI: 10.1371/Journal.Pone.0062351 |
0.355 |
|
| 2013 |
Mukherjee J, Phillips JJ, Zheng S, Wiencke J, Ronen SM, Pieper RO. Pyruvate kinase M2 expression, but not pyruvate kinase activity, is up-regulated in a grade-specific manner in human glioma. Plos One. 8: e57610. PMID 23451252 DOI: 10.1371/Journal.Pone.0057610 |
0.407 |
|
| 2012 |
See WL, Tan IL, Mukherjee J, Nicolaides T, Pieper RO. Sensitivity of glioblastomas to clinically available MEK inhibitors is defined by neurofibromin 1 deficiency. Cancer Research. 72: 3350-9. PMID 22573716 DOI: 10.1158/0008-5472.Can-12-0334 |
0.383 |
|
| 2011 |
Moreira F, Kiehl TR, So K, Ajeawung NF, Honculada C, Gould P, Pieper RO, Kamnasaran D. NPAS3 demonstrates features of a tumor suppressive role in driving the progression of Astrocytomas. The American Journal of Pathology. 179: 462-76. PMID 21703424 DOI: 10.1016/J.Ajpath.2011.03.044 |
0.428 |
|
| 2011 |
Wang D, Olman MA, Stewart J, Tipps R, Huang P, Sanders PW, Toline E, Prayson RA, Lee J, Weil RJ, Palmer CA, Gillespie GY, Liu WM, Pieper RO, Guan JL, et al. Downregulation of FIP200 induces apoptosis of glioblastoma cells and microvascular endothelial cells by enhancing Pyk2 activity. Plos One. 6: e19629. PMID 21602932 DOI: 10.1371/Journal.Pone.0019629 |
0.432 |
|
| 2011 |
Nakamura JL, Phong C, Pinarbasi E, Kogan SC, Vandenberg S, Horvai AE, Faddegon BA, Fiedler D, Shokat K, Houseman BT, Chao R, Pieper RO, Shannon K. Dose-dependent effects of focal fractionated irradiation on secondary malignant neoplasms in Nf1 mutant mice. Cancer Research. 71: 106-15. PMID 21199799 DOI: 10.1158/0008-5472.Can-10-2732 |
0.307 |
|
| 2010 |
Waldron JS, Yang I, Han S, Tihan T, Sughrue ME, Mills SA, Pieper RO, Parsa AT. Implications for immunotherapy of tumor-mediated T-cell apoptosis associated with loss of the tumor suppressor PTEN in glioblastoma. Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia. 17: 1543-7. PMID 20822910 DOI: 10.1016/J.Jocn.2010.04.021 |
0.421 |
|
| 2010 |
Panner A, Crane CA, Weng C, Feletti A, Fang S, Parsa AT, Pieper RO. Ubiquitin-specific protease 8 links the PTEN-Akt-AIP4 pathway to the control of FLIPS stability and TRAIL sensitivity in glioblastoma multiforme. Cancer Research. 70: 5046-53. PMID 20484045 DOI: 10.1158/0008-5472.Can-09-3979 |
0.37 |
|
| 2010 |
Dai B, Pieper RO, Li D, Wei P, Liu M, Woo SY, Aldape KD, Sawaya R, Xie K, Huang S. FoxM1B regulates NEDD4-1 expression, leading to cellular transformation and full malignant phenotype in immortalized human astrocytes. Cancer Research. 70: 2951-61. PMID 20332230 DOI: 10.1158/0008-5472.Can-09-3909 |
0.431 |
|
| 2010 |
Nakamura JL, Phong C, Pinarbasi E, Kogan SC, Vandenberg S, Horvai AE, Faddegon BA, Houseman BT, Pieper RO, Shannon K. Abstract 3427A: Focal fractionated irradiation induces specific malignancies in a dose-dependent manner in Nf1 mutant mice Cancer Research. 70. DOI: 10.1158/1538-7445.Am10-3427A |
0.316 |
|
| 2009 |
Han SJ, Ahn BJ, Waldron JS, Yang I, Fang S, Crane CA, Pieper RO, Parsa AT. Gamma interferon-mediated superinduction of B7-H1 in PTEN-deficient glioblastoma: a paradoxical mechanism of immune evasion. Neuroreport. 20: 1597-602. PMID 19875977 DOI: 10.1097/Wnr.0B013E32833188F7 |
0.372 |
|
| 2009 |
Panner A, Crane CA, Weng C, Feletti A, Parsa AT, Pieper RO. A novel PTEN-dependent link to ubiquitination controls FLIPS stability and TRAIL sensitivity in glioblastoma multiforme. Cancer Research. 69: 7911-6. PMID 19808964 DOI: 10.1158/0008-5472.Can-09-1287 |
0.388 |
|
| 2009 |
Crane C, Panner A, Pieper RO, Arbiser J, Parsa AT. Honokiol-mediated inhibition of PI3K/mTOR pathway: a potential strategy to overcome immunoresistance in glioma, breast, and prostate carcinoma without impacting T cell function. Journal of Immunotherapy (Hagerstown, Md. : 1997). 32: 585-92. PMID 19483651 DOI: 10.1097/Cji.0B013E3181A8Efe6 |
0.396 |
|
| 2009 |
Park S, Hatanpaa KJ, Xie Y, Mickey BE, Madden CJ, Raisanen JM, Ramnarain DB, Xiao G, Saha D, Boothman DA, Zhao D, Bachoo RM, Pieper RO, Habib AA. The receptor interacting protein 1 inhibits p53 induction through NF-kappaB activation and confers a worse prognosis in glioblastoma. Cancer Research. 69: 2809-16. PMID 19339267 DOI: 10.1158/0008-5472.Can-08-4079 |
0.379 |
|
| 2009 |
Crane CA, Panner A, Murray JC, Wilson SP, Xu H, Chen L, Simko JP, Waldman FM, Pieper RO, Parsa AT. PI(3) kinase is associated with a mechanism of immunoresistance in breast and prostate cancer. Oncogene. 28: 306-12. PMID 18850006 DOI: 10.1038/Onc.2008.384 |
0.331 |
|
| 2008 |
Dinca EB, Lu KV, Sarkaria JN, Pieper RO, Prados MD, Haas-Kogan DA, Vandenberg SR, Berger MS, James CD. p53 Small-molecule inhibitor enhances temozolomide cytotoxic activity against intracranial glioblastoma xenografts. Cancer Research. 68: 10034-9. PMID 19074867 DOI: 10.1158/0008-5472.Can-08-1687 |
0.311 |
|
| 2008 |
Nakamura JL, Garcia E, Pieper RO. S6K1 plays a key role in glial transformation. Cancer Research. 68: 6516-23. PMID 18701474 DOI: 10.1158/0008-5472.Can-07-6188 |
0.408 |
|
| 2008 |
Baia GS, Stifani S, Kimura ET, McDermott MW, Pieper RO, Lal A. Notch activation is associated with tetraploidy and enhanced chromosomal instability in meningiomas. Neoplasia (New York, N.Y.). 10: 604-12. PMID 18516297 DOI: 10.1593/Neo.08356 |
0.374 |
|
| 2008 |
Zhao Y, Xiao A, Dipierro CG, Abdel-Fattah R, Amos S, Redpath GT, Carpenter JE, Pieper RO, Hussaini IM. H-Ras increases urokinase expression and cell invasion in genetically modified human astrocytes through Ras/Raf/MEK signaling pathway. Glia. 56: 917-24. PMID 18383343 DOI: 10.1002/Glia.20667 |
0.338 |
|
| 2008 |
Chi JH, Panner A, Cachola K, Crane CA, Murray J, Pieper RO, James CD, Parsa AT. Increased expression of the glioma-associated antigen ARF4L after loss of the tumor suppressor PTEN. Laboratory investigation. Journal of Neurosurgery. 108: 299-303. PMID 18240926 DOI: 10.3171/Jns/2008/108/2/0299 |
0.44 |
|
| 2007 |
Panner A, Murray JC, Berger MS, Pieper RO. Heat shock protein 90alpha recruits FLIPS to the death-inducing signaling complex and contributes to TRAIL resistance in human glioma. Cancer Research. 67: 9482-9. PMID 17909058 DOI: 10.1158/0008-5472.Can-07-0569 |
0.363 |
|
| 2007 |
Nakamura JL, Haas-Kogan DA, Pieper RO. Glioma invasiveness responds variably to irradiation in a co-culture model. International Journal of Radiation Oncology, Biology, Physics. 69: 880-6. PMID 17889268 DOI: 10.1016/J.Ijrobp.2007.06.052 |
0.331 |
|
| 2007 |
Cobbs CS, Soroceanu L, Denham S, Zhang W, Britt WJ, Pieper R, Kraus MH. Human cytomegalovirus induces cellular tyrosine kinase signaling and promotes glioma cell invasiveness. Journal of Neuro-Oncology. 85: 271-80. PMID 17589804 DOI: 10.1007/S11060-007-9423-2 |
0.379 |
|
| 2007 |
Kanamori M, Kawaguchi T, Nigro JM, Feuerstein BG, Berger MS, Miele L, Pieper RO. Contribution of Notch signaling activation to human glioblastoma multiforme. Journal of Neurosurgery. 106: 417-27. PMID 17367064 DOI: 10.3171/Jns.2007.106.3.417 |
0.327 |
|
| 2007 |
Parsa AT, Waldron JS, Panner A, Crane CA, Parney IF, Barry JJ, Cachola KE, Murray JC, Tihan T, Jensen MC, Mischel PS, Stokoe D, Pieper RO. Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma. Nature Medicine. 13: 84-8. PMID 17159987 DOI: 10.1038/Nm1517 |
0.387 |
|
| 2007 |
Katayama M, Kawaguchi T, Berger MS, Pieper RO. DNA damaging agent-induced autophagy produces a cytoprotective adenosine triphosphate surge in malignant glioma cells Cell Death & Differentiation. 14: 548-558. PMID 16946731 DOI: 10.1038/Sj.Cdd.4402030 |
0.356 |
|
| 2006 |
Lee JC, Vivanco I, Beroukhim R, Huang JH, Feng WL, DeBiasi RM, Yoshimoto K, King JC, Nghiemphu P, Yuza Y, Xu Q, Greulich H, Thomas RK, Paez JG, Peck TC, ... ... Pieper RO, et al. Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain. Plos Medicine. 3: e485. PMID 17177598 DOI: 10.1371/Journal.Pmed.0030485 |
0.332 |
|
| 2006 |
Kawaguchi T, Yamashita Y, Kanamori M, Endersby R, Bankiewicz KS, Baker SJ, Bergers G, Pieper RO. The PTEN/Akt pathway dictates the direct alphaVbeta3-dependent growth-inhibitory action of an active fragment of tumstatin in glioma cells in vitro and in vivo. Cancer Research. 66: 11331-40. PMID 17145879 DOI: 10.1158/0008-5472.Can-06-1540 |
0.454 |
|
| 2006 |
Mirzoeva OK, Kawaguchi T, Pieper RO. The Mre11/Rad50/Nbs1 complex interacts with the mismatch repair system and contributes to temozolomide-induced G2 arrest and cytotoxicity. Molecular Cancer Therapeutics. 5: 2757-66. PMID 17121922 DOI: 10.1158/1535-7163.Mct-06-0183 |
0.336 |
|
| 2006 |
Kanamori M, Kawaguchi T, Berger MS, Pieper RO. Intracranial microenvironment reveals independent opposing functions of host alphaVbeta3 expression on glioma growth and angiogenesis. The Journal of Biological Chemistry. 281: 37256-64. PMID 17028191 DOI: 10.1074/Jbc.M605344200 |
0.307 |
|
| 2006 |
Panner A, Parsa AT, Pieper RO. Use of APO2L/TRAIL with mTOR inhibitors in the treatment of glioblastoma multiforme. Expert Review of Anticancer Therapy. 6: 1313-22. PMID 17020463 DOI: 10.1586/14737140.6.9.1313 |
0.407 |
|
| 2006 |
Panner A, Nakamura JL, Parsa AT, Rodriguez-Viciana P, Berger MS, Stokoe D, Pieper RO. mTOR-independent translational control of the extrinsic cell death pathway by RalA. Molecular and Cellular Biology. 26: 7345-57. PMID 16894031 DOI: 10.1128/Mcb.00126-06 |
0.423 |
|
| 2006 |
Panner A, Parsa AT, Pieper RO. Translational regulation of TRAIL sensitivity. Cell Cycle (Georgetown, Tex.). 5: 147-50. PMID 16397410 DOI: 10.4161/Cc.5.2.2359 |
0.382 |
|
| 2005 |
Panner A, James CD, Berger MS, Pieper RO. mTOR controls FLIPS translation and TRAIL sensitivity in glioblastoma multiforme cells. Molecular and Cellular Biology. 25: 8809-23. PMID 16199861 DOI: 10.1128/Mcb.25.20.8809-8823.2005 |
0.425 |
|
| 2005 |
Hirose Y, Katayama M, Mirzoeva OK, Berger MS, Pieper RO. Akt activation suppresses Chk2-mediated, methylating agent-induced G2 arrest and protects from temozolomide-induced mitotic catastrophe and cellular senescence. Cancer Research. 65: 4861-9. PMID 15930307 DOI: 10.1158/0008-5472.Can-04-2633 |
0.389 |
|
| 2005 |
Nakamura JL, Karlsson A, Arvold ND, Gottschalk AR, Pieper RO, Stokoe D, Haas-Kogan DA. PKB/Akt mediates radiosensitization by the signaling inhibitor LY294002 in human malignant gliomas. Journal of Neuro-Oncology. 71: 215-22. PMID 15735908 DOI: 10.1007/S11060-004-1718-Y |
0.37 |
|
| 2005 |
Rong Y, Post DE, Pieper RO, Durden DL, Van Meir EG, Brat DJ. PTEN and hypoxia regulate tissue factor expression and plasma coagulation by glioblastoma. Cancer Research. 65: 1406-13. PMID 15735028 DOI: 10.1158/0008-5472.Can-04-3376 |
0.402 |
|
| 2004 |
Saito R, Bringas JR, Panner A, Tamas M, Pieper RO, Berger MS, Bankiewicz KS. Convection-enhanced delivery of tumor necrosis factor-related apoptosis-inducing ligand with systemic administration of temozolomide prolongs survival in an intracranial glioblastoma xenograft model. Cancer Research. 64: 6858-62. PMID 15466173 DOI: 10.1158/0008-5472.Can-04-1683 |
0.36 |
|
| 2004 |
Hirose Y, Katayama M, Berger MS, Pieper RO. Cooperative function of Chk1 and p38 pathways in activating G2 arrest following exposure to temozolomide. Journal of Neurosurgery. 100: 1060-5. PMID 15200121 DOI: 10.3171/Jns.2004.100.6.1060 |
0.363 |
|
| 2004 |
Kanamori M, Vanden Berg SR, Bergers G, Berger MS, Pieper RO. Integrin beta3 overexpression suppresses tumor growth in a human model of gliomagenesis: implications for the role of beta3 overexpression in glioblastoma multiforme. Cancer Research. 64: 2751-8. PMID 15087390 DOI: 10.1158/0008-5472.Can-03-3354 |
0.344 |
|
| 2003 |
Hirose Y, Katayama M, Stokoe D, Haas-Kogan DA, Berger MS, Pieper RO. The p38 mitogen-activated protein kinase pathway links the DNA mismatch repair system to the G2 checkpoint and to resistance to chemotherapeutic DNA-methylating agents. Molecular and Cellular Biology. 23: 8306-15. PMID 14585987 DOI: 10.1128/Mcb.23.22.8306-8315.2003 |
0.398 |
|
| 2003 |
Hirose Y, Kreklau EL, Erickson LC, Berger MS, Pieper RO. Delayed repletion of O6-methylguanine-DNA methyltransferase resulting in failure to protect the human glioblastoma cell line SF767 from temozolomide-induced cytotoxicity. Journal of Neurosurgery. 98: 591-8. PMID 12650433 DOI: 10.3171/Jns.2003.98.3.0591 |
0.383 |
|
| 2003 |
Pieper RO. Defined human cellular systems in the study of glioma development. Frontiers in Bioscience : a Journal and Virtual Library. 8: s19-27. PMID 12456369 DOI: 10.2741/983 |
0.378 |
|
| 2001 |
Fanton CP, McMahon M, Pieper RO. Dual growth arrest pathways in astrocytes and astrocytic tumors in response to Raf-1 activation. Journal of Biological Chemistry. 276: 18871-18877. PMID 11278920 DOI: 10.1074/Jbc.M011514200 |
0.403 |
|
| 2000 |
Chang GH, Barbaro NM, Pieper RO. Phosphatidylserine-dependent phagocytosis of apoptotic glioma cells by normal human microglia, astrocytes, and glioma cells. Neuro-Oncology. 2: 174-83. PMID 11302338 DOI: 10.1093/Neuonc/2.3.174 |
0.384 |
|
| 1999 |
Graunke DM, Fornace AJ, Pieper RO. Presetting of chromatin structure and transcription factor binding poise the human GADD45 gene for rapid transcriptional up-regulation Nucleic Acids Research. 27: 3881-3890. PMID 10481028 DOI: 10.1093/Nar/27.19.3881 |
0.311 |
|
| 1999 |
Pieper RO, Lester KA, Fanton CP. Confluence-induced alterations in CpG island methylation in cultured normal human fibroblasts Nucleic Acids Research. 27: 3229-3235. PMID 10454622 DOI: 10.1093/Nar/27.15.3229 |
0.318 |
|
| 1997 |
Pieper RO. Understanding and manipulating O6-methylguanine-DNA methyltransferase expression Pharmacology & Therapeutics. 74: 285-297. PMID 9352585 DOI: 10.1016/S0163-7258(97)00003-X |
0.332 |
|
| 1997 |
Patel SA, Graunke DM, Pieper RO. Aberrant silencing of the CpG island-containing human O6-methylguanine DNA methyltransferase gene is associated with the loss of nucleosome-like positioning Molecular and Cellular Biology. 17: 5813-5822. PMID 9315639 DOI: 10.1128/Mcb.17.10.5813 |
0.307 |
|
| 1997 |
Watts GS, Pieper RO, Costello JF, Peng YM, Dalton WS, Futscher BW. Methylation of discrete regions of the O6-methylguanine DNA methyltransferase (MGMT) CpG island is associated with heterochromatinization of the MGMT transcription start site and silencing of the gene. Molecular and Cellular Biology. 17: 5612-9. PMID 9271436 DOI: 10.1128/Mcb.17.9.5612 |
0.349 |
|
| 1994 |
Pieper RO, Morgan SE, Kelley MR. The role of two conserved amino acids, glutamine 90 and asparagine 137, in O6-methylguanine-DNA methyltransferase stability, activity and substrate specificity. Carcinogenesis. 15: 1895-902. PMID 7923583 DOI: 10.1093/Carcin/15.9.1895 |
0.314 |
|
| 1994 |
Costello JF, Futscher BW, Kroes RA, Pieper RO. Methylation-related chromatin structure is associated with exclusion of transcription factors from and suppressed expression of the O-6-methylguanine DNA methyltransferase gene in human glioma cell lines Molecular and Cellular Biology. 14: 6515-6521. PMID 7523853 DOI: 10.1128/Mcb.14.10.6515 |
0.369 |
|
| 1992 |
Grabowski DT, Pieper RO, Futscher BW, Deutsch WA, Erickson LC, Kelley MR. Expression of ribosomal phosphoprotein PO is induced by antitumor agents and increased in Mer- human tumor cell lines. Carcinogenesis. 13: 259-63. PMID 1740017 DOI: 10.1093/Carcin/13.2.259 |
0.385 |
|
| 1992 |
Futscher BW, Pieper RO, Barnes DM, Hanin I, Erickson LC. DNA-damaging and transcription-terminating lesions induced by AF64A in vitro. Journal of Neurochemistry. 58: 1504-9. PMID 1548483 DOI: 10.1111/J.1471-4159.1992.Tb11371.X |
0.311 |
|
| 1991 |
Pieper RO, Costello JF, Kroes RA, Futscher BW, Marathi U, Erickson LC. Direct correlation between methylation status and expression of the human O-6-methylguanine DNA methyltransferase gene. Cancer Communications. 3: 241-53. PMID 1716139 DOI: 10.3727/095535491820873092 |
0.327 |
|
| 1990 |
Pieper RO, Futscher BW, Dong Q, Ellis TM, Erickson LC. Comparison of O-6-methylguanine DNA methyltransferase (MGMT) mRNA levels in Mer+ and Mer- human tumor cell lines containing the MGMT gene by the polymerase chain reaction technique. Cancer Communications. 2: 13-20. PMID 2369549 DOI: 10.3727/095535490820874812 |
0.368 |
|
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