| Year |
Citation |
Score |
| 2023 |
Brodeur MN, Dopeso H, Zhu Y, Longhini ALF, Gazzo A, Sun S, Koche R, Qu R, Hamard PJ, Bykov Y, Green H, Chiappinelli KB, Ozsoy MA, Basili T, Gardner R, et al. Interferon response and epigenetic modulation by mutations drive ovarian tumor immunogenicity. Biorxiv : the Preprint Server For Biology. PMID 37609261 DOI: 10.1101/2023.08.08.552544 |
0.425 |
|
| 2023 |
Walker RR, Chiappinelli KB. Protein Exaptation by Endogenous Retroviral Elements Shapes Tumor Cell Senescence and Downstream Immune Signaling. Cancer Research. 83: 2640-2642. PMID 37549230 DOI: 10.1158/0008-5472.CAN-23-1862 |
0.372 |
|
| 2023 |
Kim DJ, Anandh S, Null JL, Przanowski P, Bhatnagar S, Kumar P, Shelton SE, Grundy EE, Chiappinelli KB, Kamm RD, Barbie DA, Dudley AC. Priming a vascular-selective cytokine response permits CD8 T-cell entry into tumors. Nature Communications. 14: 2122. PMID 37055433 DOI: 10.1038/s41467-023-37807-z |
0.347 |
|
| 2023 |
Walker RR, Rentia Z, Chiappinelli KB. Epigenetically programmed resistance to chemo- and immuno-therapies. Advances in Cancer Research. 158: 41-71. PMID 36990538 DOI: 10.1016/bs.acr.2022.12.001 |
0.387 |
|
| 2022 |
Gomez S, Cox OL, Walker RR, Rentia U, Hadley M, Arthofer E, Diab N, Grundy EE, Kanholm T, McDonald JI, Kobyra J, Palmer E, Noonepalle S, Villagra A, Leitenberg D, ... ... Chiappinelli KB, et al. Inhibiting DNA methylation and RNA editing upregulates immunogenic RNA to transform the tumor microenvironment and prolong survival in ovarian cancer. Journal For Immunotherapy of Cancer. 10. PMID 36343976 DOI: 10.1136/jitc-2022-004974 |
0.404 |
|
| 2022 |
Chiappinelli KB, Baylin SB. Inhibiting DNA methylation improves antitumor immunity in ovarian cancer. The Journal of Clinical Investigation. 132. PMID 35838045 DOI: 10.1172/JCI160186 |
0.381 |
|
| 2021 |
Moufarrij S, Srivastava A, Gomez S, Hadley M, Palmer E, Austin PT, Chisholm S, Diab N, Roche K, Yu A, Li J, Zhu W, Lopez-Acevedo M, Villagra A, Chiappinelli KB. Author Correction: Combining DNMT and HDAC6 inhibitors increases anti-tumor immune signaling and decreases tumor burden in ovarian cancer. Scientific Reports. 11: 24423. PMID 34931014 DOI: 10.1038/s41598-021-04066-1 |
0.37 |
|
| 2021 |
McDonald JI, Diab N, Arthofer E, Hadley M, Kanholm T, Rentia U, Gomez S, Yu A, Grundy EE, Cox O, Topper MJ, Xing X, Strissel PL, Strick R, Wang T, ... ... Chiappinelli KB, et al. Epigenetic therapies in ovarian cancer alter repetitive element expression in a TP53-dependent manner. Cancer Research. PMID 34433584 DOI: 10.1158/0008-5472.CAN-20-4243 |
0.365 |
|
| 2021 |
Steiner MC, Marston JL, Iñiguez LP, Bendall ML, Chiappinelli KB, Nixon DF, Crandall KA. Locus-specific characterization of human endogenous retrovirus expression in prostate, breast, and colon cancers. Cancer Research. PMID 33941616 DOI: 10.1158/0008-5472.CAN-20-3975 |
0.401 |
|
| 2021 |
Grundy EE, Diab N, Chiappinelli KB. Transposable Element Regulation and Expression in Cancer. The Febs Journal. PMID 33471418 DOI: 10.1111/febs.15722 |
0.368 |
|
| 2020 |
Siebenkäs C, Chiappinelli KB, Guzzetta AA, Sharma A, Jeschke J, Vatapalli R, Baylin SB, Ahuja N. Correction: Inhibiting DNA methylation activates cancer testis antigens and expression of the antigen processing and presentation machinery in colon and ovarian cancer cells. Plos One. 15: e0243944. PMID 33301506 DOI: 10.1371/journal.pone.0243944 |
0.388 |
|
| 2020 |
Banik D, Noonepalle S, Hadley M, Palmer E, Gracia-Hernandez M, Zevallos-Delgado C, Manhas N, Simonyan H, Young CN, Popratiloff A, Chiappinelli KB, Fernandes R, Sotomayor EM, Villagra A. HDAC6 plays a non-canonical role in the regulation of anti-tumor immune responses, dissemination, and invasiveness of breast cancer. Cancer Research. PMID 32605998 DOI: 10.1158/0008-5472.Can-19-3738 |
0.51 |
|
| 2020 |
Moufarrij S, Srivastava A, Gomez S, Hadley M, Palmer E, Austin PT, Chisholm S, Roche K, Yu A, Li J, Zhu W, Lopez-Acevedo M, Villagra A, Chiappinelli KB. Combining DNMT and HDAC6 inhibitors increases anti-tumor immune signaling and decreases tumor burden in ovarian cancer. Scientific Reports. 10: 3470. PMID 32103105 DOI: 10.1038/S41598-020-60409-4 |
0.555 |
|
| 2020 |
Arthofer E, Diab N, Chiappinelli KB. Abstract B20: p53 regulation of repetitive elements and the interferon response in cancer Cancer Immunology Research. 8. DOI: 10.1158/2326-6074.Tumimm18-B20 |
0.52 |
|
| 2019 |
Gomez S, Tabernacki T, Kobyra J, Roberts P, Chiappinelli KB. Combining epigenetic and immune therapy to overcome cancer resistance. Seminars in Cancer Biology. PMID 31877341 DOI: 10.1016/J.Semcancer.2019.12.019 |
0.461 |
|
| 2019 |
Pfannstiel C, Strissel PL, Chiappinelli KB, Sikic D, Wach S, Wirtz R, Wullweber A, Taubert H, Breyer J, Otto W, Worst T, Burger M, Wullich B, Bolenz C, Fuhrich N, et al. The tumor immune microenvironment drives a prognostic relevance that correlates with bladder cancer subtypes. Cancer Immunology Research. PMID 30988029 DOI: 10.1158/2326-6066.Cir-18-0758 |
0.399 |
|
| 2019 |
Moufarrij S, Dandapani M, Arthofer E, Gomez S, Srivastava A, Lopez-Acevedo M, Villagra A, Chiappinelli KB. Epigenetic therapy for ovarian cancer: promise and progress. Clinical Epigenetics. 11: 7. PMID 30646939 DOI: 10.1186/S13148-018-0602-0 |
0.48 |
|
| 2019 |
Strissel P, Pfannstiel C, Chiappinelli K, Sikic D, Wach S, Wirtz R, Wullweber A, Taubert H, Breyer J, Otto W, Worst T, Burger M, Wullich B, Bolenz C, Fuhrich N, et al. Tumor immune microenvironment drives prognostic relevance correlating with bladder cancer subtypes European Urology Supplements. 18: e1455-e1456. DOI: 10.1016/S1569-9056(19)31049-8 |
0.368 |
|
| 2018 |
Stone ML, Chiappinelli KB, Li H, Murphy LM, Travers ME, Topper MJ, Mathios D, Lim M, Shih IM, Wang TL, Hung CF, Bhargava V, Wiehagen KR, Cowley GS, Bachman KE, et al. Reply to Haffner et al.: DNA hypomethylation renders tumors more immunogenic. Proceedings of the National Academy of Sciences of the United States of America. PMID 30181297 DOI: 10.1073/Pnas.1811015115 |
0.478 |
|
| 2018 |
Nogues JC, Wang ZM, Chisholm SS, Smith M, Sotomayor E, Chiappinelli K. The Effect of TET Mutations on DNA Methyltransferase Cytotoxicity and ERV Induction in B and T Cell Malignancies Blood. 132: 5157-5157. DOI: 10.1182/Blood-2018-99-120281 |
0.391 |
|
| 2018 |
Srivastava AP, Moufarrij SM, Hadley M, Chisholm S, Lopez-Acevedo M, Villagra A, Chiappinelli KB. Abstract 1395: HDAC6 and DNMT inhibition affect immunogenicity of ovarian cancer cells: A rationale for combining epigenetic and immune therapy in ovarian cancer Cancer Research. 78: 1395-1395. DOI: 10.1158/1538-7445.Am2018-1395 |
0.532 |
|
| 2017 |
Stone ML, Chiappinelli KB, Li H, Murphy LM, Travers ME, Topper MJ, Mathios D, Lim M, Shih IM, Wang TL, Hung CF, Bhargava V, Wiehagen KR, Cowley GS, Bachman KE, et al. Epigenetic therapy activates type I interferon signaling in murine ovarian cancer to reduce immunosuppression and tumor burden. Proceedings of the National Academy of Sciences of the United States of America. PMID 29203668 DOI: 10.1073/Pnas.1712514114 |
0.52 |
|
| 2017 |
Topper MJ, Vaz M, Chiappinelli KB, DeStefano Shields CE, Niknafs N, Yen RC, Wenzel A, Hicks J, Ballew M, Stone M, Tran PT, Zahnow CA, Hellmann MD, Anagnostou V, Strissel PL, et al. Epigenetic Therapy Ties MYC Depletion to Reversing Immune Evasion and Treating Lung Cancer. Cell. 171: 1284-1300.e21. PMID 29195073 DOI: 10.1016/J.Cell.2017.10.022 |
0.48 |
|
| 2017 |
Siebenkäs C, Chiappinelli KB, Guzzetta AA, Sharma A, Jeschke J, Vatapalli R, Baylin SB, Ahuja N. Inhibiting DNA methylation activates cancer testis antigens and expression of the antigen processing and presentation machinery in colon and ovarian cancer cells. Plos One. 12: e0179501. PMID 28622390 DOI: 10.1371/journal.pone.0179501 |
0.465 |
|
| 2017 |
Chiappinelli KB, Strissel PL, Desrichard A, Li H, Henke C, Akman B, Hein A, Rote NS, Cope LM, Snyder A, Makarov V, Budhu S, Slamon DJ, Wolchok JD, Pardoll DM, et al. Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses. Cell. 169: 361. PMID 28388418 DOI: 10.1016/J.Cell.2017.03.036 |
0.464 |
|
| 2017 |
Strissel PL, Chiappinelli KB, Strehl J, Würfel FM, Beckmann MW, Baylin SB, Strick R. Abstract A55: Human endogenous retroviruses differentially regulate immune checkpoints and modulation of immune responses in serous ovarian carcinoma. Cancer Immunology Research. 5. DOI: 10.1158/2326-6074.Tumimm16-A55 |
0.414 |
|
| 2017 |
Hadley M, Shen S, Banik D, Kim J, Nair J, Knox T, Gallub V, Kirkland S, Chiappinelli KB, Sotomayor E, Kozikowski A, Villagra A. Abstract LB-294:In vivoevaluation of Ames negative HDAC6 inhibitor in melanoma model Cancer Research. 77. DOI: 10.1158/1538-7445.Am2017-Lb-294 |
0.461 |
|
| 2017 |
Topper M, Vaz M, Chiappinelli K, Shields CD, Wenzel A, Zahnow C, Strissel P, Strick R, Baylin S. Abstract LB-098: Sequential azacitidine and histone deacetylase inhibition induces a potent antitumor response in Kras G12D mouse model of NSCLC Cancer Research. 77. DOI: 10.1158/1538-7445.Am2017-Lb-098 |
0.441 |
|
| 2016 |
Strick R, Strissel PL, Baylin SB, Chiappinelli KB. Unraveling the molecular pathways of DNA-methylation inhibitors: human endogenous retroviruses induce the innate immune response in tumors. Oncoimmunology. 5: e1122160. PMID 27467919 DOI: 10.1080/2162402X.2015.1122160 |
0.492 |
|
| 2016 |
Chiappinelli KB, Strissel PL, Desrichard A, Li H, Henke C, Akman B, Hein A, Rote NS, Cope LM, Snyder A, Makarov V, Budhu S, Slamon DJ, Wolchok JD, Pardoll DM, et al. Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses. Cell. 164: 1073. PMID 27064190 DOI: 10.1016/J.Cell.2015.10.020 |
0.464 |
|
| 2016 |
Chiappinelli KB, Zahnow CA, Ahuja N, Baylin SB. Combining Epigenetic and Immunotherapy to Combat Cancer. Cancer Research. 76: 1683-9. PMID 26988985 DOI: 10.1158/0008-5472.Can-15-2125 |
0.517 |
|
| 2016 |
Chiappinelli KB, Strissel PL, Desrichard A, Li H, Henke C, Akman B, Hein A, Rote NS, Cope LM, Snyder A, Makarov V, Budhu S, Wolchok J, Zahnow CA, Mergoub T, et al. Abstract B32: Inhibiting DNA methylation causes an interferon response in cancer via dsRNA including endogenous retroviruses Cancer Research. 76. DOI: 10.1158/1538-7445.Chromepi15-B32 |
0.541 |
|
| 2016 |
Stone ML, Chiappinelli KB, Li H, Murphy L, Topper M, Baylin S, Zahnow C. Abstract 4907: Epigenetic treatment of ovarian cancer cells increases immune cell recruitment to the tumor microenvironment: implications for response to immune checkpoint therapy Cancer Research. 76: 4907-4907. DOI: 10.1158/1538-7445.Am2016-4907 |
0.478 |
|
| 2016 |
Topper M, Hanigan C, Vaz M, Chiappinelli K, Justin J, Murphy L, Zahnow C, Baylin S. Abstract 4653: Combination Azacitidine and histone deacetylase inhibition induces a multi factorial synergistic anti-tumor response in non-small cell lung cancer (NSCLC) Cancer Research. 76: 4653-4653. DOI: 10.1158/1538-7445.Am2016-4653 |
0.526 |
|
| 2016 |
Chiappinelli KB, Stone ML, Topper MJ, Murphy L, Strissel PL, Strick R, Zahnow CA, Baylin SB. Abstract 4019: Inhibiting DNA methylation causes an interferon response in cancer cells via endogenous retroviruses and recruits immune cells to the tumor microenvironment to sensitize to immune therapy Cancer Research. 76: 4019-4019. DOI: 10.1158/1538-7445.Am2016-4019 |
0.524 |
|
| 2015 |
Bowtell DD, Böhm S, Ahmed AA, Aspuria PJ, Bast RC, Beral V, Berek JS, Birrer MJ, Blagden S, Bookman MA, Brenton JD, Chiappinelli KB, Martins FC, Coukos G, Drapkin R, et al. Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer. Nature Reviews. Cancer. 15: 668-79. PMID 26493647 DOI: 10.1038/Nrc4019 |
0.444 |
|
| 2015 |
Chiappinelli KB, Strissel PL, Desrichard A, Li H, Henke C, Akman B, Hein A, Rote NS, Cope LM, Snyder A, Makarov V, Buhu S, Slamon DJ, Wolchok JD, Pardoll DM, et al. Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses. Cell. 162: 974-86. PMID 26317466 DOI: 10.1016/J.Cell.2015.07.011 |
0.519 |
|
| 2015 |
Chiappinelli KB, Strissel P, Yen RC, Li H, Stone ML, Murphy L, Akman B, Zahnow CA, Strick R, Baylin SB. Abstract NG07: Immunomodulatory and tumor cell killing effects of the demethylating agent 5-azacytidine in ovarian cancer Cancer Research. 75. DOI: 10.1158/1538-7445.Am2015-Ng07 |
0.488 |
|
| 2015 |
Chiappinelli KB, Strissel PL, Desrichard A, Li H, Henke C, Akman B, Hein A, Rote NS, Cope LM, Snyder A, Makarov V, Buhu S, Slamon DJ, Wolchok JD, Pardoll DM, et al. Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses Cell. 162: 974-986. DOI: 10.1016/j.cell.2015.07.011 |
0.374 |
|
| 2014 |
Zhang B, Xing X, Li J, Lowdon RF, Zhou Y, Lin N, Zhang B, Sundaram V, Chiappinelli KB, Hagemann IS, Mutch DG, Goodfellow PJ, Wang T. Comparative DNA methylome analysis of endometrial carcinoma reveals complex and distinct deregulation of cancer promoters and enhancers. Bmc Genomics. 15: 868. PMID 25286960 DOI: 10.1186/1471-2164-15-868 |
0.599 |
|
| 2014 |
Li H, Chiappinelli KB, Guzzetta AA, Easwaran H, Yen RW, Vatapalli R, Topper MJ, Luo J, Connolly RM, Azad NS, Stearns V, Pardoll DM, Davidson N, Jones PA, Slamon DJ, et al. Immune regulation by low doses of the DNA methyltransferase inhibitor 5-azacitidine in common human epithelial cancers. Oncotarget. 5: 587-98. PMID 24583822 DOI: 10.18632/Oncotarget.1782 |
0.548 |
|
| 2013 |
Yi JM, Guzzetta AA, Bailey VJ, Downing SR, Van Neste L, Chiappinelli KB, Keeley BP, Stark A, Herrera A, Wolfgang C, Pappou EP, Iacobuzio-Donahue CA, Goggins MG, Herman JG, Wang TH, et al. Novel methylation biomarker panel for the early detection of pancreatic cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 6544-55. PMID 24088737 DOI: 10.1158/1078-0432.Ccr-12-3224 |
0.466 |
|
| 2013 |
Yin Y, Kizer NT, Thaker PH, Chiappinelli KB, Trinkaus KM, Goodfellow PJ, Ma L. Glycogen synthase kinase 3β inhibition as a therapeutic approach in the treatment of endometrial cancer. International Journal of Molecular Sciences. 14: 16617-37. PMID 23941783 DOI: 10.1016/J.Ygyno.2011.12.352 |
0.636 |
|
| 2013 |
Chiappinelli KB, Yen RC, Li H, Topper M, Zahnow CA, Baylin SB. Abstract PR12: Immunomodulatory effects of 5-Azacyditine in ovarian cancer cell lines Clinical Cancer Research. 19. DOI: 10.1158/1078-0432.Ovca13-Pr12 |
0.582 |
|
| 2012 |
Chiappinelli KB, Haynes BC, Brent MR, Goodfellow PJ. Reduced DICER1 elicits an interferon response in endometrial cancer cells. Molecular Cancer Research : McR. 10: 316-25. PMID 22252463 DOI: 10.1158/1541-7786.Mcr-11-0520 |
0.625 |
|
| 2012 |
Ioffe YJ, Chiappinelli KB, Mutch DG, Zighelboim I, Goodfellow PJ. Phosphatase and tensin homolog (PTEN) pseudogene expression in endometrial cancer: a conserved regulatory mechanism important in tumorigenesis? Gynecologic Oncology. 124: 340-6. PMID 22005521 DOI: 10.1016/J.Ygyno.2011.10.011 |
0.662 |
|
| 2012 |
Sundaram V, Xie M, Zhang B, Chiappinelli KB, Goodfellow PJ, Wang T. Abstract LB-379: Transposable elements and the epigenetic control of gene regulation of endometrial cancer Cancer Research. 72. DOI: 10.1158/1538-7445.Am2012-Lb-379 |
0.578 |
|
| 2012 |
Chiappinelli KB, Haynes BC, Brent MR, Goodfellow PJ. Abstract 2312: A genomics approach to determining the role of DICER1 in tumorigenesis: Interferon responses in the cancer cell Cancer Research. 72: 2312-2312. DOI: 10.1158/1538-7445.Am2012-2312 |
0.604 |
|
| 2011 |
Chiappinelli KB, Haynes BC, Schillebeeckx M, Mitra RD, Brent MR, Goodfellow PJ. Abstract 1173: A genomics approach to understanding DICER1's role in tumorigenesis Cancer Research. 71: 1173-1173. DOI: 10.1158/1538-7445.Am2011-1173 |
0.646 |
|
| 2010 |
Ramsingh G, Koboldt DC, Trissal M, Chiappinelli KB, Wylie T, Koul S, Chang LW, Nagarajan R, Fehniger TA, Goodfellow P, Magrini V, Wilson RK, Ding L, Ley TJ, Mardis ER, et al. Complete characterization of the microRNAome in a patient with acute myeloid leukemia. Blood. 116: 5316-26. PMID 20876853 DOI: 10.1182/Blood-2010-05-285395 |
0.574 |
|
| 2010 |
Chiappinelli KB, Rimel BJ, Massad LS, Goodfellow PJ. Infrequent methylation of the DUSP6 phosphatase in endometrial cancer. Gynecologic Oncology. 119: 146-50. PMID 20638106 DOI: 10.1016/J.Ygyno.2010.06.015 |
0.626 |
|
| 2010 |
Ramsingh G, Koboldt DC, Trissal M, Chiappinelli KB, Wylie T, Koul S, Chang L, Nagarajan R, Fehniger TA, Goodfellow P, Magrini V, Wilson RK, Ding L, Ley TJ, Mardis ER, et al. Abstract B12: Complete characterization of the “microRNAome” of a human acute myeloid leukemia Clinical Cancer Research. 16. DOI: 10.1158/1078-0432.Tcmusa10-B12 |
0.564 |
|
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