Rachel F. Tyndale, Ph.D. - Publications

Affiliations: 
Departments of Pharmacology and Toxicology and Psychiatry CAMH/University of Toronto 
Area:
Addiction, Drug Metabolism
Website:
http://www.pharmtox.utoronto.ca/faculty/directory/tyndale.htm

276 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Schaefer KR, Avey JP, Todd MR, Beans JA, Dillard DA, Shireman LM, Thornton TA, Tyndale RF, Thummel KE, Robinson RF, Claw KG. Nicotine metabolism and its association with CYP2A6 genotype among Indigenous people in Alaska who smoke. Clinical and Translational Science. PMID 34520119 DOI: 10.1111/cts.13115  0.354
2021 El-Boraie A, Tyndale RF. The Role of Pharmacogenetics in Smoking. Clinical Pharmacology and Therapeutics. PMID 34165800 DOI: 10.1002/cpt.2345  0.339
2021 Giratallah HK, Chenoweth MJ, Addo N, Ahluwalia JS, Cox LS, Lerman C, George TP, Benowitz NL, Tyndale RF. Nicotine metabolite ratio: Comparison of the three urinary versions to the plasma version and nicotine clearance in three clinical studies. Drug and Alcohol Dependence. 223: 108708. PMID 33873029 DOI: 10.1016/j.drugalcdep.2021.108708  0.326
2021 Butler K, Chenoweth MJ, El-Boraie A, Giratallah H, Kowalczyk WJ, Heishman SJ, Tyndale RF, Le Foll B. Impact Of Cyp2a6 Activity On Nicotine Reinforcement And Cue-Reactivity In Daily Smokers. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 33823003 DOI: 10.1093/ntr/ntab064  0.369
2021 Schnoll R, Paul Wileyto E, Bauer AM, Fox E, Leone F, Lerman C, Tyndale RF, George TP, Hawk L, Cinciripini P, Quinn M, Purnell J, Hatzell J, Hitsman B. Comparing the Rate of Nicotine Metabolism Among Smokers With Current or Past Major Depressive Disorder. The American Journal On Addictions. PMID 33772971 DOI: 10.1111/ajad.13155  0.313
2021 Liakoni E, Tyndale RF, Jacob P, Dempsey DA, Addo N, Benowitz NL. Effect of race and glucuronidation rates on the relationship between nicotine metabolite ratio and nicotine clearance. Pharmacogenetics and Genomics. PMID 33675323 DOI: 10.1097/FPC.0000000000000427  0.336
2020 Gao Y, Miksys S, Palmour RM, Tyndale RF. The influence of tobacco smoke/nicotine on CYP2A expression in Human and African Green Monkey Lungs. Molecular Pharmacology. PMID 33055223 DOI: 10.1124/molpharm.120.000100  0.334
2020 McMillan DM, El-Sherbeni AA, Richards J, Tyndale RF. Centrally administered CYP2D inhibitors increase oral tramadol analgesia in rats. Brain Research Bulletin. PMID 32926950 DOI: 10.1016/J.Brainresbull.2020.09.001  0.359
2020 Frie JA, Underhill J, Zhao B, de Guglielmo G, Tyndale RF, Khokhar JY. OpenVape: an Open-Source E-Cigarette Vapour Exposure Device for Rodents. Eneuro. PMID 32859723 DOI: 10.1523/ENEURO.0279-20.2020  0.682
2020 Henderson JA, Buchwald DS, Howard BV, Henderson PN, Li Y, Tyndale RF, Amos CI, Gorlova OY. Genetics of smoking behavior in American Indians. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. PMID 32855268 DOI: 10.1158/1055-9965.Epi-20-0026  0.354
2020 Bray MJ, Chen LS, Fox L, Hancock DB, Culverhouse RC, Hartz SM, Johnson EO, Liu M, McKay JD, Saccone NL, Hokanson JE, Vrieze SI, Tyndale RF, Baker TB, Bierut LJ. Dissecting the genetic overlap of smoking behaviors, lung cancer, and chronic obstructive pulmonary disease: A focus on nicotinic receptors and nicotine metabolizing enzyme. Genetic Epidemiology. PMID 32803792 DOI: 10.1002/Gepi.22331  0.419
2020 Stocco MR, Tolledo C, Wadji FB, Gonzalez FJ, Miksys S, Tyndale RF. Human CYP2D6 in the Brain Is Protective Against Harmine-Induced Neurotoxicity: Evidence from Humanized CYP2D6 Transgenic Mice. Molecular Neurobiology. PMID 32761352 DOI: 10.1007/S12035-020-02050-W  0.314
2020 Higgins ST, DeSarno M, Davis DR, Nighbor T, Streck JM, Adise S, Harfmann R, Nesheim-Case R, Markesich C, Reed D, Tyndale RF, Gaalema DE, Heil SH, Sigmon SC, Tidey JW, et al. Relating individual differences in nicotine dependence severity to underpinning motivational and pharmacological processes among smokers from vulnerable populations. Preventive Medicine. 106189. PMID 32628945 DOI: 10.1016/J.Ypmed.2020.106189  0.428
2020 Zawertailo L, Hendershot CS, Tyndale RF, Le Foll B, Samokhvalov AV, Thorpe KE, Pipe A, Reid RD, Selby P. Personalized dosing of nicotine replacement therapy versus standard dosing for the treatment of individuals with tobacco dependence: study protocol for a randomized placebo-controlled trial. Trials. 21: 592. PMID 32600406 DOI: 10.1186/S13063-020-04532-7  0.427
2020 Schlagintweit HE, Tyndale RF, Hendershot CS. Acute effects of a very low nicotine content cigarette on laboratory smoking lapse: Impacts of nicotine metabolism and nicotine dependence. Addiction Biology. e12930. PMID 32573054 DOI: 10.1111/Adb.12930  0.468
2020 Schnoll R, Paul Wileyto E, Gross R, Hitsman B, Hawk LW, Cinciripini P, George TP, Benowitz NL, Fen Lubitz S, Ashare R, Tyndale RF, Lerman C. Evaluation of nicotine patch adherence measurement using self-report and saliva cotinine among abstainers in a smoking cessation trial. Drug and Alcohol Dependence. 210: 107967. PMID 32224420 DOI: 10.1016/J.Drugalcdep.2020.107967  0.409
2020 Tolledo C, Stocco MR, Miksys S, Gonzalez FJ, Tyndale RF. Human CYP2D6 Is Functional in Brain In Vivo: Evidence from Humanized CYP2D6 Transgenic Mice. Molecular Neurobiology. PMID 32189192 DOI: 10.1007/S12035-020-01896-4  0.332
2020 Buchwald J, Chenoweth MJ, Palviainen T, Zhu G, Benner C, Gordon S, Korhonen T, Ripatti S, Madden PAF, Lehtimäki T, Raitakari OT, Salomaa V, Rose RJ, George TP, Lerman C, ... ... Tyndale RF, et al. Genome-wide association meta-analysis of nicotine metabolism and cigarette consumption measures in smokers of European descent. Molecular Psychiatry. PMID 32157176 DOI: 10.1038/S41380-020-0702-Z  0.328
2020 Cunningham JA, Kushnir V, Selby P, Zawertailo L, Tyndale RF, Leatherdale ST, Schell C. Five-Year Follow-up of a Randomized Clinical Trial Testing Mailed Nicotine Patches to Promote Tobacco Cessation. Jama Internal Medicine. PMID 32150239 DOI: 10.1001/Jamainternmed.2020.0001  0.364
2020 Best LM, Williams B, Le Foll B, Mansouri E, Bazinet RP, Lin L, De Luca V, Lagzdins D, Rusjan P, Tyndale RF, Wilson AA, Hendershot CS, Heilig M, Houle S, Tong J, et al. Lower brain fatty acid amide hydrolase in treatment-seeking patients with alcohol use disorder: a positron emission tomography study with [C-11]CURB. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 31910433 DOI: 10.1038/S41386-020-0606-2  0.334
2019 Mansouri E, Nobrega JN, Hill MN, Tyndale RF, Lee FS, Hendershot CS, Best LM, Di Ciano P, Balsevich G, Sloan ME, Kish SJ, Tong J, Le Foll B, Boileau I. D3 dopamine receptors and a missense mutation of fatty acid amide hydrolase linked in mouse and men: implication for addiction. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 31775159 DOI: 10.1038/S41386-019-0580-8  0.307
2019 Liakoni E, Nardone N, St Helen G, Dempsey DA, Tyndale RF, Benowitz NL. Effects of Nicotine Metabolic Rate on Cigarette Reinforcement. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 31725872 DOI: 10.1093/Ntr/Ntz210  0.468
2019 Akinola LS, Mckiver B, Toma W, Zhu AZX, Tyndale RF, Kumar V, Damaj MI. C57BL/6 Substrain Differences in Pharmacological Effects after Acute and Repeated Nicotine Administration. Brain Sciences. 9. PMID 31546627 DOI: 10.3390/Brainsci9100244  0.344
2019 Liakoni E, St Helen G, Dempsey DA, Jacob P, Tyndale RF, Benowitz NL. Relationship between skin melanin index and nicotine pharmacokinetics in African American smokers. Drug and Alcohol Dependence. 204: 107474. PMID 31521954 DOI: 10.1016/J.Drugalcdep.2019.04.039  0.451
2019 Peng AR, Swardfager W, Benowitz NL, Ahluwalia JS, Lerman C, Nollen NL, Tyndale RF. Impact of Early Nausea on Varenicline Adherence and Smoking Cessation. Addiction (Abingdon, England). PMID 31502736 DOI: 10.1111/Add.14810  0.341
2019 Claw KG, Beans JA, Lee SB, Avey JP, Stapleton PA, Scherer SE, El-Boraie A, Tyndale RF, Nickerson DA, Dillard DA, Thummel KE, Robinson RF. Pharmacogenomics of nicotine metabolism: novel CYP2A6 and CYP2B6 genetic variation patterns in Alaska Native and American Indian populations. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 31241144 DOI: 10.1093/Ntr/Ntz105  0.461
2019 St Helen G, Benowitz NL, Ahluwalia JS, Tyndale RF, Addo N, Gregorich SE, Pérez-Stable EJ, Cox LS. Black Light Smokers: How Nicotine Intake and Carcinogen Exposure Differ Across Various Biobehavioral Factors. Journal of the National Medical Association. PMID 31084916 DOI: 10.1016/J.Jnma.2019.04.004  0.306
2019 El-Boraie A, Taghavi T, Chenoweth MJ, Fukunaga K, Mushiroda T, Kubo M, Lerman C, Nollen NL, Benowitz NL, Tyndale RF. Evaluation of a weighted genetic risk score for the prediction of biomarkers of CYP2A6 activity. Addiction Biology. PMID 30815984 DOI: 10.1111/Adb.12741  0.458
2019 Arguelles N, Wadji FB, Novalen M, Miksys S, Tyndale R. Sex differences in brain oxycodone metabolism and analgesia Drug Metabolism and Pharmacokinetics. 34: S29. DOI: 10.1016/J.Dmpk.2018.09.114  0.325
2019 Peng AR, Schnoll R, Lerman C, Tyndale RF. Different measures of varenicline adherence, nicotine metabolite ratio and smoking abstinence Drug Metabolism and Pharmacokinetics. 34: S16-S17. DOI: 10.1016/J.Dmpk.2018.09.077  0.445
2018 Mercincavage M, Lochbuehler K, Wileyto EP, Benowitz NL, Tyndale RF, Lerman C, Strasser AA. Association of Reduced Nicotine Content Cigarettes With Smoking Behaviors and Biomarkers of Exposure Among Slow and Fast Nicotine Metabolizers: A Nonrandomized Clinical Trial. Jama Network Open. 1. PMID 30627706 DOI: 10.1001/jamanetworkopen.2018.1346  0.37
2018 Dermody SS, Hendershot CS, Andrade AK, Novalen M, Tyndale RF. Changes in Nicotine Metabolite Ratio among Daily Smokers receiving Treatment for Alcohol Use Disorder. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 30561731 DOI: 10.1093/Ntr/Nty265  0.403
2018 Schnoll RA, Thompson M, Serrano K, Leone F, Metzger D, Frank I, Gross R, Mounzer K, Tyndale RF, Weisbrot J, Meline M, Collman RG, Ashare RL. Rate of Nicotine Metabolism and Tobacco Use among Persons with HIV: Implications for Treatment and Research. Journal of Acquired Immune Deficiency Syndromes (1999). PMID 30399039 DOI: 10.1097/Qai.0000000000001895  0.453
2018 Faulkner P, Ghahremani DG, Tyndale RF, Paterson NE, Cox C, Ginder N, Hellemann G, London ED. Neural basis of smoking-induced relief of craving and negative affect: Contribution of nicotine. Addiction Biology. PMID 30307083 DOI: 10.1111/Adb.12679  0.328
2018 Shahab L, Bauld L, McNeill A, Tyndale RF. Does the nicotine metabolite ratio moderate smoking cessation treatment outcomes in real-world settings? A prospective study. Addiction (Abingdon, England). PMID 30276911 DOI: 10.1111/add.14450  0.324
2018 Liakoni E, Edwards KC, St Helen G, Nardone N, Dempsey DA, Tyndale RF, Benowitz NL. Effects of Nicotine Metabolic Rate on withdrawal symptoms and response to cigarette smoking following abstinence. Clinical Pharmacology and Therapeutics. PMID 30242831 DOI: 10.1002/Cpt.1238  0.485
2018 Arger CA, Taghavi T, Heil SH, Skelly J, Tyndale RF, Higgins ST. Pregnancy-Induced Increases in the Nicotine Metabolite Ratio: Examining Changes During Antepartum and Postpartum. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 30165458 DOI: 10.1093/Ntr/Nty172  0.415
2018 Borrie AE, Rose RV, Choi YH, Perera FE, Read N, Sexton T, Lock M, Vandenberg TA, Hahn K, Dinniwell R, Younus J, Logan D, Potvin K, Yaremko B, Yu E, ... ... Tyndale RF, et al. Letrozole concentration is associated with CYP2A6 variation but not with arthralgia in patients with breast cancer. Breast Cancer Research and Treatment. PMID 30094551 DOI: 10.1007/S10549-018-4910-Z  0.3
2018 Crawford G, Jao N, Peng AR, Leone F, Kalhan R, Tyndale RF, Weisbrot J, Hitsman B, Schnoll R. The association between self-reported varenicline adherence and varenicline blood levels in a sample of cancer patients receiving treatment for tobacco dependence. Addictive Behaviors Reports. 8: 46-50. PMID 29998189 DOI: 10.1016/J.Abrep.2018.06.006  0.307
2018 Faulkner P, Ghahremani DG, Tyndale RF, Hellemann G, London ED. Functional Connectivity of the Raphe Nuclei: Link to Tobacco Withdrawal in Smokers. The International Journal of Neuropsychopharmacology. PMID 29924326 DOI: 10.1093/Ijnp/Pyy054  0.402
2018 Taghavi T, Arger CA, Heil SH, Higgins ST, Tyndale RF. Cigarette Consumption and Biomarkers of Nicotine Exposure during Pregnancy and Postpartum. Addiction (Abingdon, England). PMID 29920836 DOI: 10.1111/Add.14367  0.436
2018 Taghavi T, Novalen M, Lerman C, George TP, Tyndale RF. A comparison of direct and indirect analytical approaches to measuring total nicotine equivalents in urine. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. PMID 29853480 DOI: 10.1158/1055-9965.Epi-18-0018  0.404
2018 Di Ciano P, Tyndale RF, Mansouri E, Hendershot CS, Wilson AA, Lagzdins D, Houle S, Boileau I, Le Foll B. Influence of Nicotine Metabolism Ratio on [11C]-(+)-PHNO PET binding in Tobacco Smokers. The International Journal of Neuropsychopharmacology. PMID 29346545 DOI: 10.1093/Ijnp/Pyx119  0.49
2018 Tanner JA, Zhu AZ, Claw KG, Prasad B, Korchina V, Hu J, Doddapaneni H, Muzny DM, Schuetz EG, Lerman C, Thummel KE, Scherer SE, Tyndale RF. Novel CYP2A6 diplotypes identified through next-generation sequencing are associated with in-vitro and in-vivo nicotine metabolism. Pharmacogenetics and Genomics. 28: 7-16. PMID 29232328 DOI: 10.1097/Fpc.0000000000000317  0.385
2018 Wang J, Conti D, Epeldegui M, Ollikainen M, Hwang AE, Hamilton AS, Magpantay L, Tyndale R, Mack TM, Martinez-Maza O, Kaprio J, Cozen W. Abstract 3228: Tobacco smoking and circulating immune-related biomarkers in monozygotic twins Cancer Research. 78: 3228-3228. DOI: 10.1158/1538-7445.Am2018-3228  0.366
2018 Taghavi T, Arger CA, Heil SH, Higgins ST, Tyndale RF. Changes in nicotine metabolic pathways across pregnancy: A longitudinal study Drug Metabolism and Pharmacokinetics. 33: S38-S39. DOI: 10.1016/J.Dmpk.2017.11.138  0.379
2017 Tanner JA, Tyndale RF. Variation in CYP2A6 Activity and Personalized Medicine. Journal of Personalized Medicine. 7. PMID 29194389 DOI: 10.3390/jpm7040018  0.339
2017 McMillan DM, Tyndale RF. CYP-mediated drug metabolism in the brain impacts drug response. Pharmacology & Therapeutics. PMID 29024742 DOI: 10.1016/J.Pharmthera.2017.10.008  0.344
2017 Faulkner P, Petersen N, Ghahremani DG, Cox CM, Tyndale RF, Hellemann GS, London ED. Sex differences in tobacco withdrawal and responses to smoking reduced-nicotine cigarettes in young smokers. Psychopharmacology. PMID 29022071 DOI: 10.1007/S00213-017-4755-X  0.444
2017 Chenoweth MJ, Ware JJ, Zhu AZX, Cole CB, Cox LS, Nollen N, Ahluwalia JS, Benowitz NL, Schnoll RA, Hawk LW, Cinciripini PM, George TP, Lerman C, Knight J, Tyndale RF, et al. Genome-wide association study of a nicotine metabolism biomarker in African American smokers: impact of chromosome 19 genetic influences. Addiction (Abingdon, England). PMID 28921760 DOI: 10.1111/Add.14032  0.365
2017 Kushnir V, Selby P, Zawertailo L, Tyndale RF, Leatherdale ST, Cunningham JA. Long-term effectiveness of mailed nicotine replacement therapy: study protocol of a randomized controlled trial 5-year follow-up. Bmc Public Health. 18: 28. PMID 28720080 DOI: 10.1186/S12889-017-4586-Z  0.367
2017 Ware JJ, Tanner JA, Taylor AE, Bin Z, Haycock P, Bowden J, Rogers PJ, Davey Smith G, Tyndale RF, Munafo MR. Does coffee consumption impact on heaviness of smoking? Addiction (Abingdon, England). PMID 28556459 DOI: 10.1111/Add.13888  0.351
2017 Ashare RL, Lerman C, Tyndale RF, Hawk LW, George TP, Cinciripini P, Schnoll RA. Sleep Disturbance During Smoking Cessation: Withdrawal or Side Effect of Treatment? Journal of Smoking Cessation. 12: 63-70. PMID 28553407 DOI: 10.1017/Jsc.2016.11  0.327
2017 Tanner JA, Henderson JA, Buchwald D, Howard BV, Nez Henderson P, Tyndale RF. Relationships between smoking behaviors and cotinine levels among two American Indian populations with distinct smoking patterns. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 28549179 DOI: 10.1093/Ntr/Ntx114  0.363
2017 Cunningham JA, Kushnir V, Selby P, Tyndale RF, Zawertailo L, Leatherdale ST. Beyond quitting: Any additional impact of mailing free nicotine patches to current smokers? Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 28521035 DOI: 10.1093/Ntr/Ntx106  0.42
2017 Jao NC, Veluz-Wilkins AK, Smith MJ, Carroll AJ, Blazekovic S, Leone FT, Tyndale RF, Schnoll RA, Hitsman B. Does menthol cigarette use moderate the effect of nicotine metabolism on short-term smoking cessation? Experimental and Clinical Psychopharmacology. 25: 216-222. PMID 28493744 DOI: 10.1037/Pha0000124  0.461
2017 Saccone NL, Baurley JW, Bergen AW, David SP, Elliott HR, Foreman MG, Kaprio J, Piasecki TM, Relton CL, Zawertailo L, Bierut LJ, Tyndale RF, Chen LS. The Value of Biosamples in Smoking Cessation Trials: A Review of Genetic, Metabolomic, and Epigenetic Findings. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 28472521 DOI: 10.1093/Ntr/Ntx096  0.381
2017 Tanner JA, Henderson JA, Buchwald D, Howard BV, Nez Henderson P, Tyndale RF. Variation in CYP2A6 and nicotine metabolism among two American Indian tribal groups differing in smoking patterns and risk for tobacco-related cancer. Pharmacogenetics and Genomics. PMID 28181923 DOI: 10.1097/FPC.0000000000000271  0.311
2017 Taghavi T, St Helen G, Benowitz NL, Tyndale RF. Effect of UGT2B10, UGT2B17, FMO3, and OCT2 genetic variation on nicotine and cotinine pharmacokinetics and smoking in African Americans. Pharmacogenetics and Genomics. PMID 28178031 DOI: 10.1097/Fpc.0000000000000269  0.491
2017 Faulkner P, Ghahremani DG, Tyndale RF, Cox CM, Kazanjian AS, Paterson N, Lotfipour S, Hellemann GS, Petersen N, Vigil C, London ED. Reduced-Nicotine Cigarettes in Young Smokers: Impact of Nicotine Metabolism on Nicotine Dose Effects. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 28117337 DOI: 10.1038/Npp.2017.18  0.376
2017 Gaalema D, Tidey JW, Tyndale R, Higgins S. Nicotine metabolite ratio and associations with smoking topography in a population with affective disorders Drug and Alcohol Dependence. 171: e67-e68. DOI: 10.1016/J.Drugalcdep.2016.08.195  0.419
2016 Moerke MJ, Zhu AZ, Tyndale RF, Javors MA, McMahon LR. The discriminative stimulus effects of i.v. nicotine in rhesus monkeys: Pharmacokinetics and apparent pA2 analysis with dihydro-β-erythroidine. Neuropharmacology. PMID 27940077 DOI: 10.1016/J.Neuropharm.2016.12.003  0.331
2016 Li S, Yang Y, Hoffmann E, Tyndale RF, Stein EA. CYP2A6 Genetic Variation Alters Striatal-Cingulate Circuits, Network Hubs, and Executive Processing in Smokers. Biological Psychiatry. PMID 27865452 DOI: 10.1016/J.Biopsych.2016.09.013  0.423
2016 Chenoweth MJ, Tyndale RF. Pharmacogenetic Optimization of Smoking Cessation Treatment. Trends in Pharmacological Sciences. PMID 27712845 DOI: 10.1016/J.Tips.2016.09.006  0.445
2016 Kushnir V, Sproule BA, Zawertailo L, Selby P, Tyndale RF, Leatherdale ST, Cunningham JA. Impact of self-reported lifetime depression or anxiety on effectiveness of mass distribution of nicotine patches. Tobacco Control. PMID 27543563 DOI: 10.1136/Tobaccocontrol-2016-052994  0.369
2016 Garcia KL, Lê AD, Tyndale RF. Brain CYP2B induction can decrease nicotine levels in the brain. Addiction Biology. PMID 27230546 DOI: 10.1111/adb.12411  0.353
2016 Rabin RA, Ashare RL, Schnoll RA, Cinciripini PM, Hawk LW, Lerman C, Tyndale RF, George TP. Does cannabis use moderate smoking cessation outcomes in treatment-seeking tobacco smokers? Analysis from a large multi-center trial. The American Journal On Addictions / American Academy of Psychiatrists in Alcoholism and Addictions. PMID 27187893 DOI: 10.1111/Ajad.12382  0.391
2016 Ross KC, Gubner NR, Tyndale RF, Hawk LW, Lerman C, George TP, Cinciripini P, Schnoll RA, Benowitz NL. Racial differences in the relationship between rate of nicotine metabolism and nicotine intake from cigarette smoking. Pharmacology, Biochemistry, and Behavior. PMID 27180107 DOI: 10.1016/J.Pbb.2016.05.002  0.377
2016 Chen J, Bacanu SA, Yu H, Zhao Z, Jia P, Kendler KS, Kranzler HR, Gelernter J, Farrer L, Minica C, Pool R, Milaneschi Y, Boomsma DI, Penninx BW, Tyndale RF, et al. Genetic Relationship between Schizophrenia and Nicotine Dependence. Scientific Reports. 6: 25671. PMID 27164557 DOI: 10.1038/Srep25671  0.309
2016 Benowitz NL, St Helen G, Dempsey DA, Jacob P, Tyndale RF. Disposition kinetics and metabolism of nicotine and cotinine in African American smokers: impact of CYP2A6 genetic variation and enzymatic activity. Pharmacogenetics and Genomics. PMID 27035242 DOI: 10.1097/Fpc.0000000000000222  0.495
2016 Ware JJ, Chen X, Vink J, Loukola A, Minica C, Pool R, Milaneschi Y, Mangino M, Menni C, Chen J, Peterson RE, Auro K, Lyytikäinen LP, Wedenoja J, Stiby AI, ... ... Tyndale RF, et al. Genome-Wide Meta-Analysis of Cotinine Levels in Cigarette Smokers Identifies Locus at 4q13.2. Scientific Reports. 6: 20092. PMID 26833182 DOI: 10.1038/Srep20092  0.319
2016 Cunningham JA, Kushnir V, Selby P, Tyndale RF, Zawertailo L, Leatherdale ST. Effect of Mailing Nicotine Patches on Tobacco Cessation Among Adult Smokers : A Randomized Clinical Trial. Jama Internal Medicine. PMID 26809849 DOI: 10.1001/Jamainternmed.2015.7792  0.399
2015 Falcone M, Cao W, Bernardo L, Tyndale RF, Loughead J, Lerman C. Brain Responses to Smoking Cues Differ Based on Nicotine Metabolism Rate. Biological Psychiatry. PMID 26805583 DOI: 10.1016/J.Biopsych.2015.11.015  0.38
2015 Wassenaar CA, Zhou Q, Tyndale RF. CYP2A6 genotyping methods and strategies using real-time and endpoint PCR platforms. Pharmacogenomics. PMID 26670214 DOI: 10.2217/pgs.15.156  0.316
2015 Nollen NL, Cox LS, Yu Q, Ellerbeck EF, Scheuermann TS, Benowitz NL, Tyndale RF, Mayo MS, Ahluwalia JS. A clinical trial to examine disparities in quitting between African-American and White adult smokers: Design, accrual, and baseline characteristics. Contemporary Clinical Trials. PMID 26667382 DOI: 10.1016/J.Cct.2015.12.001  0.327
2015 Chenoweth MJ, Sylvestre MP, Contreras G, Novalen M, O'Loughlin J, Tyndale RF. Variation in CYP2A6 and tobacco dependence throughout adolescence and in young adult smokers. Drug and Alcohol Dependence. PMID 26644138 DOI: 10.1016/J.Drugalcdep.2015.11.017  0.467
2015 Di Ciano P, Guranda M, Lagzdins D, Tyndale RF, Gamaleddin I, Selby P, Boileau I, Le Foll B. Varenicline-Induced Elevation of Dopamine in Smokers: A Preliminary [(11)C]-(+)-PHNO PET Study. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 26442600 DOI: 10.1038/Npp.2015.305  0.393
2015 Loukola A, Buchwald J, Gupta R, Palviainen T, Hällfors J, Tikkanen E, Korhonen T, Ollikainen M, Sarin AP, Ripatti S, Lehtimäki T, Raitakari O, Salomaa V, Rose RJ, Tyndale RF, et al. A Genome-Wide Association Study of a Biomarker of Nicotine Metabolism. Plos Genetics. 11: e1005498. PMID 26407342 DOI: 10.1371/Journal.Pgen.1005498  0.39
2015 Alsharari SD, King JR, Nordman JC, Muldoon PP, Jackson A, Zhu AZ, Tyndale RF, Kabbani N, Damaj MI. Effects of Menthol on Nicotine Pharmacokinetic, Pharmacology and Dependence in Mice. Plos One. 10: e0137070. PMID 26355604 DOI: 10.1371/Journal.Pone.0137070  0.36
2015 Dubroff JG, Doot RK, Falcone M, Schnoll RA, Ray R, Tyndale RF, Brody AL, Hou C, Schmitz A, Lerman C. Decreased Nicotinic Receptor Availability in Smokers with Slow Rates of Nicotine Metabolism. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 56: 1724-9. PMID 26272810 DOI: 10.2967/Jnumed.115.155002  0.444
2015 Kaufmann A, Hitsman B, Goelz PM, Veluz-Wilkins A, Blazekovic S, Powers L, Leone FT, Gariti P, Tyndale RF, Schnoll RA. Rate of Nicotine Metabolism and Smoking Cessation Outcomes in a Community-based Sample of Treatment-Seeking Smokers. Addictive Behaviors. 51: 93-9. PMID 26240944 DOI: 10.1016/J.Addbeh.2015.07.019  0.438
2015 Bergen AW, Michel M, Nishita D, Krasnow R, Javitz HS, Conneely KN, Lessov-Schlaggar CN, Hops H, Zhu AZ, Baurley JW, McClure JB, Hall SM, Baker TB, Conti DV, Benowitz NL, ... ... Tyndale RF, et al. Drug Metabolizing Enzyme and Transporter Gene Variation, Nicotine Metabolism, Prospective Abstinence, and Cigarette Consumption. Plos One. 10: e0126113. PMID 26132489 DOI: 10.1371/Journal.Pone.0126113  0.326
2015 Chenoweth MJ, Schnoll RA, Novalen M, Hawk LW, George TP, Cinciripini PM, Lerman C, Tyndale RF. The Nicotine Metabolite Ratio is Associated With Early Smoking Abstinence Even After Controlling for Factors That Influence the Nicotine Metabolite Ratio. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 26069034 DOI: 10.1093/Ntr/Ntv125  0.477
2015 Tanner JA, Novalen M, Jatlow P, Huestis MA, Murphy SE, Kaprio J, Kankaanpää A, Galanti L, Stefan C, George TP, Benowitz NL, Lerman C, Tyndale RF. Nicotine Metabolite Ratio (3-Hydroxycotinine/Cotinine) in Plasma and Urine by Different Analytical Methods and Laboratories: Implications for Clinical Implementation. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. PMID 26014804 DOI: 10.1158/1055-9965.Epi-14-1381  0.484
2015 Foti RS, Tyndale RF, Garcia KL, Sweet DH, Nagar S, Sharan S, Rock DA. "Target-Site" Drug Metabolism and Transport. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 43: 1156-68. PMID 25986849 DOI: 10.1124/Dmd.115.064576  0.335
2015 Hamilton DA, Mahoney MC, Novalen M, Chenoweth MJ, Heitjan DF, Lerman C, Tyndale RF, Hawk LW. Test-Retest Reliability and Stability of the Nicotine Metabolite Ratio Among Treatment-Seeking Smokers. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 25732567 DOI: 10.1093/Ntr/Ntv031  0.397
2015 Tanner JA, Chenoweth MJ, Tyndale RF. Pharmacogenetics of nicotine and associated smoking behaviors. Current Topics in Behavioral Neurosciences. 23: 37-86. PMID 25655887 DOI: 10.1007/978-3-319-13665-3_3  0.489
2015 Garcia KL, Coen K, Miksys S, Lê AD, Tyndale RF. Effect of Brain CYP2B Inhibition on Brain Nicotine Levels and Nicotine Self-Administration. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 40: 1910-8. PMID 25652250 DOI: 10.1038/npp.2015.40  0.375
2015 McMillan DM, Tyndale RF. Nicotine Increases Codeine Analgesia Through the Induction of Brain CYP2D and Central Activation of Codeine to Morphine. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 40: 1804-12. PMID 25630571 DOI: 10.1038/npp.2015.32  0.331
2015 Lerman C, Schnoll RA, Hawk LW, Cinciripini P, George TP, Wileyto EP, Swan GE, Benowitz NL, Heitjan DF, Tyndale RF. Use of the nicotine metabolite ratio as a genetically informed biomarker of response to nicotine patch or varenicline for smoking cessation: a randomised, double-blind placebo-controlled trial. The Lancet. Respiratory Medicine. 3: 131-8. PMID 25588294 DOI: 10.1016/S2213-2600(14)70294-2  0.354
2015 Bandiera FC, Ross KC, Taghavi S, Delucchi K, Tyndale RF, Benowitz NL. Nicotine Dependence, Nicotine Metabolism, and the Extent of Compensation in Response to Reduced Nicotine Content Cigarettes. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 25555385 DOI: 10.1093/Ntr/Ntu337  0.474
2015 Wassenaar CA, Conti DV, Das S, Chen P, Cook EH, Ratain MJ, Benowitz NL, Tyndale RF. UGT1A and UGT2B genetic variation alters nicotine and nitrosamine glucuronidation in european and african american smokers. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 24: 94-104. PMID 25277794 DOI: 10.1158/1055-9965.Epi-14-0804  0.482
2015 Alsharari SD, King JR, Nordman JC, Muldoon PP, Jackson A, Zhu AZX, Tyndale RF, Kabbani N, Damaj MI. Nicotine plasma levels in adult male ICR mouse after pre-treatment with vehicle or menthol in the withdrawal testing. Plos One. DOI: 10.1371/Journal.Pone.0137070.T004  0.336
2015 Alsharari SD, King JR, Nordman JC, Muldoon PP, Jackson A, Zhu AZX, Tyndale RF, Kabbani N, Damaj MI. Blockade of menthol’s effects on nicotine acute pharmacological responses after administration in mice. Plos One. DOI: 10.1371/Journal.Pone.0137070.T002  0.36
2015 Alsharari SD, King JR, Nordman JC, Muldoon PP, Jackson A, Zhu AZX, Tyndale RF, Kabbani N, Damaj MI. Impact of menthol treatment on nicotine pharmacokinetic parameters. Plos One. DOI: 10.1371/Journal.Pone.0137070.T001  0.375
2015 Alsharari SD, King JR, Nordman JC, Muldoon PP, Jackson A, Zhu AZX, Tyndale RF, Kabbani N, Damaj MI. Effects of menthol on nicotine withdrawal signs. (A) Elevated plus-maze test, (B) Somatic signs and in (C) Hyperalgesia. Plos One. DOI: 10.1371/Journal.Pone.0137070.G005  0.359
2015 Alsharari SD, King JR, Nordman JC, Muldoon PP, Jackson A, Zhu AZX, Tyndale RF, Kabbani N, Damaj MI. Effects of menthol pretreatment on nicotine-induced antinociception and hypothermia dose-response curves in mice. Plos One. DOI: 10.1371/Journal.Pone.0137070.G004  0.339
2015 Alsharari SD, King JR, Nordman JC, Muldoon PP, Jackson A, Zhu AZX, Tyndale RF, Kabbani N, Damaj MI. Time course of nicotine plasma concentrations in mice pretreated with menthol. Plos One. DOI: 10.1371/Journal.Pone.0137070.G001  0.33
2014 Tani N, Juvonen RO, Raunio H, Fashe M, Leppänen J, Zhao B, Tyndale RF, Rahnasto-Rilla M. Rational design of novel CYP2A6 inhibitors. Bioorganic & Medicinal Chemistry. 22: 6655-64. PMID 25458499 DOI: 10.1016/J.Toxlet.2013.05.407  0.422
2014 Zhu AZ, Zhou Q, Cox LS, Ahluwalia JS, Benowitz NL, Tyndale RF. Gene variants in CYP2C19 are associated with altered in vivo bupropion pharmacokinetics but not bupropion-assisted smoking cessation outcomes. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 42: 1971-7. PMID 25187485 DOI: 10.1124/Dmd.114.060285  0.438
2014 Chenoweth MJ, Novalen M, Hawk LW, Schnoll RA, George TP, Cinciripini PM, Lerman C, Tyndale RF. Known and novel sources of variability in the nicotine metabolite ratio in a large sample of treatment-seeking smokers. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 23: 1773-82. PMID 25012994 DOI: 10.1158/1055-9965.Epi-14-0427  0.484
2014 Craig EL, Zhao B, Cui JZ, Novalen M, Miksys S, Tyndale RF. Nicotine pharmacokinetics in rats is altered as a function of age, impacting the interpretation of animal model data. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 42: 1447-55. PMID 24980255 DOI: 10.1124/dmd.114.058719  0.34
2014 Bagdas D, Muldoon PP, Zhu AZ, Tyndale RF, Damaj MI. Effects of methoxsalen, a CYP2A5/6 inhibitor, on nicotine dependence behaviors in mice. Neuropharmacology. 85: 67-72. PMID 24859605 DOI: 10.1016/J.Neuropharm.2014.05.006  0.376
2014 Khokhar JY, Tyndale RF. Intracerebroventricularly and systemically delivered inhibitor of brain CYP2B (C8-Xanthate), even following chlorpyrifos exposure, reduces chlorpyrifos activation and toxicity in male rats. Toxicological Sciences : An Official Journal of the Society of Toxicology. 140: 49-60. PMID 24798379 DOI: 10.1093/Toxsci/Kfu075  0.638
2014 Zhu AZ, Zhou Q, Cox LS, David SP, Ahluwalia JS, Benowitz NL, Tyndale RF. Association of CHRNA5-A3-B4 SNP rs2036527 with smoking cessation therapy response in African-American smokers. Clinical Pharmacology and Therapeutics. 96: 256-65. PMID 24733007 DOI: 10.1038/Clpt.2014.88  0.386
2014 Miller RT, Miksys S, Hoffmann E, Tyndale RF. Ethanol self-administration and nicotine treatment increase brain levels of CYP2D in African green monkeys. British Journal of Pharmacology. 171: 3077-88. PMID 24611668 DOI: 10.1111/bph.12652  0.321
2014 Chenoweth MJ, Zhu AZ, Sanderson Cox L, Ahluwalia JS, Benowitz NL, Tyndale RF. Variation in P450 oxidoreductase (POR) A503V and flavin-containing monooxygenase (FMO)-3 E158K is associated with minor alterations in nicotine metabolism, but does not alter cigarette consumption. Pharmacogenetics and Genomics. 24: 172-6. PMID 24448396 DOI: 10.1097/Fpc.0000000000000031  0.492
2014 Schnoll RA, George TP, Hawk L, Cinciripini P, Wileyto P, Tyndale RF. The relationship between the nicotine metabolite ratio and three self-report measures of nicotine dependence across sex and race. Psychopharmacology. 231: 2515-23. PMID 24402139 DOI: 10.1007/S00213-013-3421-1  0.453
2014 Piliguian M, Zhu AZ, Zhou Q, Benowitz NL, Ahluwalia JS, Sanderson Cox L, Tyndale RF. Novel CYP2A6 variants identified in African Americans are associated with slow nicotine metabolism in vitro and in vivo. Pharmacogenetics and Genomics. 24: 118-28. PMID 24305170 DOI: 10.1097/Fpc.0000000000000026  0.503
2014 Alsharari SD, Siu EC, Tyndale RF, Damaj MI. Pharmacokinetic and pharmacodynamics studies of nicotine after oral administration in mice: effects of methoxsalen, a CYP2A5/6 inhibitor. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 16: 18-25. PMID 23884323 DOI: 10.1093/ntr/ntt105  0.35
2014 Wassenaar CA, Ye Y, Cai Q, Aldrich M, Knight J, Spitz MR, Wu X, Blot WJ, Tyndale RF. Abstract 4149: Genetic variation in CYP2A6, a nicotine/nitrosamine metabolism enzyme, influences lung cancer risk in two independent case-control studies of African American smokers Cancer Research. 74: 4149-4149. DOI: 10.1158/1538-7445.Am2014-4149  0.37
2013 David SP, Strong DR, Leventhal AM, Lancaster MA, McGeary JE, Munafò MR, Bergen AW, Swan GE, Benowitz NL, Tyndale RF, Conti DV, Brown RA, Lerman C, Niaura R. Influence of a dopamine pathway additive genetic efficacy score on smoking cessation: results from two randomized clinical trials of bupropion. Addiction (Abingdon, England). 108: 2202-11. PMID 23941313 DOI: 10.1111/Add.12325  0.373
2013 Zhu AZ, Zhou Q, Cox LS, Ahluwalia JS, Benowitz NL, Tyndale RF. Variation in trans-3'-hydroxycotinine glucuronidation does not alter the nicotine metabolite ratio or nicotine intake. Plos One. 8: e70938. PMID 23936477 DOI: 10.1371/Journal.Pone.0070938  0.485
2013 Dempsey DA, St Helen G, Jacob P, Tyndale RF, Benowitz NL. Genetic and pharmacokinetic determinants of response to transdermal nicotine in white, black, and Asian nonsmokers. Clinical Pharmacology and Therapeutics. 94: 687-94. PMID 23933970 DOI: 10.1038/Clpt.2013.159  0.468
2013 Nollen NL, Mayo MS, Ahluwalia JS, Tyndale RF, Benowitz NL, Faseru B, Buchanan TS, Cox LS. Factors associated with discontinuation of bupropion and counseling among African American light smokers in a randomized clinical trial. Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine. 46: 336-48. PMID 23733379 DOI: 10.1007/S12160-013-9510-X  0.346
2013 Zhu AZ, Renner CC, Hatsukami DK, Benowitz NL, Tyndale RF. CHRNA5-A3-B4 genetic variants alter nicotine intake and interact with tobacco use to influence body weight in Alaska Native tobacco users. Addiction (Abingdon, England). 108: 1818-28. PMID 23692359 DOI: 10.1111/Add.12250  0.429
2013 Ferguson CS, Miksys S, Palmour RM, Tyndale RF. Ethanol self-administration and nicotine treatment induce brain levels of CYP2B6 and CYP2E1 in African green monkeys. Neuropharmacology. 72: 74-81. PMID 23639433 DOI: 10.1016/J.Neuropharm.2013.04.022  0.639
2013 Zhou K, Khokhar JY, Zhao B, Tyndale RF. First demonstration that brain CYP2D-mediated opiate metabolic activation alters analgesia in vivo. Biochemical Pharmacology. 85: 1848-55. PMID 23623752 DOI: 10.1016/J.Bcp.2013.04.014  0.691
2013 Wassenaar CA, Dong Q, Amos CI, Spitz MR, Tyndale RF. Pilot Study of CYP2B6 Genetic Variation to Explore the Contribution of Nitrosamine Activation to Lung Carcinogenesis. International Journal of Molecular Sciences. 14: 8381-92. PMID 23591849 DOI: 10.3390/Ijms14048381  0.365
2013 Bough KJ, Lerman C, Rose JE, McClernon FJ, Kenny PJ, Tyndale RF, David SP, Stein EA, Uhl GR, Conti DV, Green C, Amur S. Biomarkers for smoking cessation. Clinical Pharmacology and Therapeutics. 93: 526-38. PMID 23588313 DOI: 10.1038/Clpt.2013.57  0.364
2013 Miksys S, Cappendijk SL, Perry WM, Zhao B, Tyndale RF. Nicotine kinetics in zebra finches in vivo and in vitro. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 1240-6. PMID 23530019 DOI: 10.1124/Dmd.112.050765  0.491
2013 Chenoweth MJ, O'Loughlin J, Sylvestre MP, Tyndale RF. CYP2A6 slow nicotine metabolism is associated with increased quitting by adolescent smokers. Pharmacogenetics and Genomics. 23: 232-5. PMID 23462429 DOI: 10.1097/FPC.0b013e32835f834d  0.339
2013 Esterlis I, Hannestad JO, Perkins E, Bois F, D'Souza DC, Tyndale RF, Seibyl JP, Hatsukami DM, Cosgrove KP, O'Malley SS. Effect of a nicotine vaccine on nicotine binding to β2*-nicotinic acetylcholine receptors in vivo in human tobacco smokers. The American Journal of Psychiatry. 170: 399-407. PMID 23429725 DOI: 10.1176/Appi.Ajp.2012.12060793  0.344
2013 Zhu AZ, Renner CC, Hatsukami DK, Swan GE, Lerman C, Benowitz NL, Tyndale RF. The ability of plasma cotinine to predict nicotine and carcinogen exposure is altered by differences in CYP2A6: the influence of genetics, race, and sex. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 22: 708-18. PMID 23371292 DOI: 10.1158/1055-9965.Epi-12-1234-T  0.462
2013 Sellings L, Pereira S, Qian C, Dixon-McDougall T, Nowak C, Zhao B, Tyndale RF, van der Kooy D. Nicotine-motivated behavior in Caenorhabditis elegans requires the nicotinic acetylcholine receptor subunits acr-5 and acr-15. The European Journal of Neuroscience. 37: 743-56. PMID 23351035 DOI: 10.1111/Ejn.12099  0.435
2013 Benowitz NL, Zhu AZ, Tyndale RF, Dempsey D, Jacob P. Influence of CYP2B6 genetic variants on plasma and urine concentrations of bupropion and metabolites at steady state. Pharmacogenetics and Genomics. 23: 135-41. PMID 23344581 DOI: 10.1097/Fpc.0B013E32835D9Ab0  0.35
2013 Faseru B, Nollen NL, Mayo MS, Krebill R, Choi WS, Benowitz NL, Tyndale RF, Okuyemi KS, Ahluwalia JS, Sanderson Cox L. Predictors of cessation in African American light smokers enrolled in a bupropion clinical trial. Addictive Behaviors. 38: 1796-803. PMID 23254230 DOI: 10.1016/J.Addbeh.2012.11.010  0.363
2013 Bergen AW, Javitz HS, Krasnow R, Nishita D, Michel M, Conti DV, Liu J, Lee W, Edlund CK, Hall S, Kwok PY, Benowitz NL, Baker TB, Tyndale RF, Lerman C, et al. Nicotinic acetylcholine receptor variation and response to smoking cessation therapies. Pharmacogenetics and Genomics. 23: 94-103. PMID 23249876 DOI: 10.1097/Fpc.0B013E32835Cdabd  0.407
2013 Miksys S, Tyndale RF. Cytochrome P450-mediated drug metabolism in the brain. Journal of Psychiatry & Neuroscience : Jpn. 38: 152-63. PMID 23199531 DOI: 10.1503/Jpn.120133  0.378
2013 Esterlis I, Hannestad JO, Bois F, Sewell RA, Tyndale RF, Seibyl JP, Picciotto MR, Laruelle M, Carson RE, Cosgrove KP. Imaging changes in synaptic acetylcholine availability in living human subjects. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 54: 78-82. PMID 23160789 DOI: 10.2967/Jnumed.112.111922  0.372
2013 Zhu AZ, Binnington MJ, Renner CC, Lanier AP, Hatsukami DK, Stepanov I, Watson CH, Sosnoff CS, Benowitz NL, Tyndale RF. Alaska Native smokers and smokeless tobacco users with slower CYP2A6 activity have lower tobacco consumption, lower tobacco-specific nitrosamine exposure and lower tobacco-specific nitrosamine bioactivation. Carcinogenesis. 34: 93-101. PMID 23027621 DOI: 10.1093/Carcin/Bgs306  0.314
2013 Renner CC, Lanier AP, Lindgren B, Jensen J, Patten CA, Parascandola M, Benowitz NL, Tyndale RF, Hatsukami DK. Tobacco use among southwestern Alaska Native people. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 15: 401-6. PMID 22949573 DOI: 10.1093/Ntr/Nts137  0.372
2013 Schnoll RA, Wileyto EP, Leone FT, Tyndale RF, Benowitz NL. High dose transdermal nicotine for fast metabolizers of nicotine: a proof of concept placebo-controlled trial. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 15: 348-54. PMID 22589423 DOI: 10.1093/Ntr/Nts129  0.454
2013 Benowitz NL, Dempsey D, Tyndale RF, St Helen G, Jacob P. Dose-independent kinetics with low level exposure to nicotine and cotinine. British Journal of Clinical Pharmacology. 75: 277-9. PMID 22574797 DOI: 10.1111/J.1365-2125.2012.04327.X  0.488
2012 Zhu AZ, Cox LS, Nollen N, Faseru B, Okuyemi KS, Ahluwalia JS, Benowitz NL, Tyndale RF. CYP2B6 and bupropion's smoking-cessation pharmacology: the role of hydroxybupropion. Clinical Pharmacology and Therapeutics. 92: 771-7. PMID 23149928 DOI: 10.1038/Clpt.2012.186  0.42
2012 Ferguson CS, Miksys S, Palmour RM, Tyndale RF. Differential effects of nicotine treatment and ethanol self-administration on CYP2A6, CYP2B6 and nicotine pharmacokinetics in African green monkeys. The Journal of Pharmacology and Experimental Therapeutics. 343: 628-37. PMID 22935730 DOI: 10.1124/jpet.112.198564  0.628
2012 Mahar I, Bagot RC, Davoli MA, Miksys S, Tyndale RF, Walker CD, Maheu M, Huang SH, Wong TP, Mechawar N. Developmental hippocampal neuroplasticity in a model of nicotine replacement therapy during pregnancy and breastfeeding. Plos One. 7: e37219. PMID 22615944 DOI: 10.1371/Journal.Pone.0037219  0.431
2012 Binnington MJ, Zhu AZ, Renner CC, Lanier AP, Hatsukami DK, Benowitz NL, Tyndale RF. CYP2A6 and CYP2B6 genetic variation and its association with nicotine metabolism in South Western Alaska Native people. Pharmacogenetics and Genomics. 22: 429-40. PMID 22569203 DOI: 10.1097/Fpc.0B013E3283527C1C  0.478
2012 St Helen G, Novalen M, Heitjan DF, Dempsey D, Jacob P, Aziziyeh A, Wing VC, George TP, Tyndale RF, Benowitz NL. Reproducibility of the nicotine metabolite ratio in cigarette smokers. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 21: 1105-14. PMID 22552800 DOI: 10.1158/1055-9965.Epi-12-0236  0.317
2012 Lee W, Ray R, Bergen AW, Swan GE, Thomas P, Tyndale RF, Benowitz NL, Lerman C, Conti DV. DRD1 associations with smoking abstinence across slow and normal nicotine metabolizers. Pharmacogenetics and Genomics. 22: 551-4. PMID 22495174 DOI: 10.1097/Fpc.0B013E3283539062  0.499
2012 Benowitz NL, Renner CC, Lanier AP, Tyndale RF, Hatsukami DK, Lindgren B, Stepanov I, Watson CH, Sosnoff CS, Jacob P. Exposure to nicotine and carcinogens among Southwestern Alaskan Native cigarette smokers and smokeless tobacco users. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 21: 934-42. PMID 22490317 DOI: 10.1158/1055-9965.Epi-11-1178  0.418
2012 Tang DW, Hello B, Mroziewicz M, Fellows LK, Tyndale RF, Dagher A. Genetic variation in CYP2A6 predicts neural reactivity to smoking cues as measured using fMRI. Neuroimage. 60: 2136-43. PMID 22342802 DOI: 10.1016/j.neuroimage.2012.01.119  0.353
2012 Khokhar JY, Tyndale RF. Rat brain CYP2B-enzymatic activation of chlorpyrifos to the oxon mediates cholinergic neurotoxicity. Toxicological Sciences : An Official Journal of the Society of Toxicology. 126: 325-35. PMID 22287024 DOI: 10.1093/Toxsci/Kfs029  0.655
2012 Cox LS, Nollen NL, Mayo MS, Choi WS, Faseru B, Benowitz NL, Tyndale RF, Okuyemi KS, Ahluwalia JS. Bupropion for smoking cessation in African American light smokers: a randomized controlled trial. Journal of the National Cancer Institute. 104: 290-8. PMID 22282543 DOI: 10.1093/Jnci/Djr513  0.368
2012 Kohli U, Pandharipande P, Muszkat M, Sofowora GG, Friedman EA, Scheinin M, Wood AJ, Ely EW, Tyndale RF, Choi L, Stein CM, Kurnik D. CYP2A6 genetic variation and dexmedetomidine disposition. European Journal of Clinical Pharmacology. 68: 937-42. PMID 22271297 DOI: 10.1007/S00228-011-1208-Z  0.352
2012 Liu T, David SP, Tyndale RF, Wang H, Yu XQ, Chen W, Zhou Q, Chen WQ. Relationship between amounts of daily cigarette consumption and abdominal obesity moderated by CYP2A6 genotypes in Chinese male current smokers. Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine. 43: 253-61. PMID 22160797 DOI: 10.1007/S12160-011-9318-5  0.393
2012 Mann A, Miksys SL, Gaedigk A, Kish SJ, Mash DC, Tyndale RF. The neuroprotective enzyme CYP2D6 increases in the brain with age and is lower in Parkinson's disease patients. Neurobiology of Aging. 33: 2160-71. PMID 21958961 DOI: 10.1016/J.Neurobiolaging.2011.08.014  0.523
2012 Zhu AZX, Tyndale RF. Nicotine Metabolism and its Implications Metabolism of Drugs and Other Xenobiotics. 465-492. DOI: 10.1002/9783527630905.ch17  0.33
2011 Ferguson CS, Tyndale RF. Cytochrome P450 enzymes in the brain: emerging evidence of biological significance. Trends in Pharmacological Sciences. 32: 708-14. PMID 21975165 DOI: 10.1016/j.tips.2011.08.005  0.552
2011 Cunningham JA, Leatherdale ST, Selby PL, Tyndale RF, Zawertailo L, Kushnir V. Randomized controlled trial of mailed Nicotine Replacement Therapy to Canadian smokers: study protocol. Bmc Public Health. 11: 741. PMID 21955930 DOI: 10.1186/1471-2458-11-741  0.388
2011 Ferguson CS, Miksys S, Palmour R, Tyndale RF. Independent and combined effects of ethanol self-administration and nicotine treatment on hepatic CYP2E1 in African green monkeys. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 39: 2233-41. PMID 21868470 DOI: 10.1124/Dmd.111.040378  0.609
2011 Wassenaar CA, Dong Q, Wei Q, Amos CI, Spitz MR, Tyndale RF. Relationship between CYP2A6 and CHRNA5-CHRNA3-CHRNB4 variation and smoking behaviors and lung cancer risk. Journal of the National Cancer Institute. 103: 1342-6. PMID 21747048 DOI: 10.1093/Jnci/Djr237  0.369
2011 Falcone M, Jepson C, Benowitz N, Bergen AW, Pinto A, Wileyto EP, Baldwin D, Tyndale RF, Lerman C, Ray R. Association of the nicotine metabolite ratio and CHRNA5/CHRNA3 polymorphisms with smoking rate among treatment-seeking smokers. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 13: 498-503. PMID 21385908 DOI: 10.1093/Ntr/Ntr012  0.366
2011 Cox LS, Faseru B, Mayo MS, Krebill R, Snow TS, Bronars CA, Nollen NL, Choi WS, Okuyemi KS, Salzman GA, Benowitz NL, Tyndale RF, Ahluwalia JS. Design, baseline characteristics, and retention of African American light smokers into a randomized trial involving biological data. Trials. 12: 22. PMID 21266057 DOI: 10.1186/1745-6215-12-22  0.399
2011 Strasser AA, Benowitz NL, Pinto AG, Tang KZ, Hecht SS, Carmella SG, Tyndale RF, Lerman CE. Nicotine metabolite ratio predicts smoking topography and carcinogen biomarker level. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 20: 234-8. PMID 21212060 DOI: 10.1158/1055-9965.Epi-10-0674  0.451
2011 Khokhar JY, Tyndale RF. Drug metabolism within the brain changes drug response: selective manipulation of brain CYP2B alters propofol effects. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 692-700. PMID 21107310 DOI: 10.1038/Npp.2010.202  0.676
2011 Mwenifumbo JC, Tyndale RF. DSM-IV, ICD-10 and FTND: Discordant Tobacco Dependence Diagnoses in Adult Smokers Journal of Addiction Research & Therapy. 2. DOI: 10.4172/2155-6105.1000105  0.336
2010 Ho MK, Goldman D, Heinz A, Kaprio J, Kreek MJ, Li MD, Munafò MR, Tyndale RF. Breaking barriers in the genomics and pharmacogenetics of drug addiction. Clinical Pharmacology and Therapeutics. 88: 779-91. PMID 20981002 DOI: 10.1038/Clpt.2010.175  0.597
2010 Khokhar JY, Miksys SL, Tyndale RF. Rat brain CYP2B induction by nicotine is persistent and does not involve nicotinic acetylcholine receptors. Brain Research. 1348: 1-9. PMID 20599831 DOI: 10.1016/J.Brainres.2010.06.035  0.715
2010 Mann A, Tyndale RF. Cytochrome P450 2D6 enzyme neuroprotects against 1-methyl-4-phenylpyridinium toxicity in SH-SY5Y neuronal cells. The European Journal of Neuroscience. 31: 1185-93. PMID 20345925 DOI: 10.1111/J.1460-9568.2010.07142.X  0.621
2010 Lerman C, Jepson C, Wileyto EP, Patterson F, Schnoll R, Mroziewicz M, Benowitz N, Tyndale RF. Genetic variation in nicotine metabolism predicts the efficacy of extended-duration transdermal nicotine therapy. Clinical Pharmacology and Therapeutics. 87: 553-7. PMID 20336063 DOI: 10.1038/Clpt.2010.3  0.43
2010 Al Koudsi N, Tyndale RF. Hepatic CYP2B6 is altered by genetic, physiologic, and environmental factors but plays little role in nicotine metabolism. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 40: 381-92. PMID 20307138 DOI: 10.3109/00498251003713958  0.415
2010 Mwenifumbo JC, Zhou Q, Benowitz NL, Sellers EM, Tyndale RF. New CYP2A6 gene deletion and conversion variants in a population of Black African descent. Pharmacogenomics. 11: 189-98. PMID 20136358 DOI: 10.2217/Pgs.09.144  0.405
2010 Khokhar JY, Ferguson CS, Zhu AZ, Tyndale RF. Pharmacogenetics of drug dependence: role of gene variations in susceptibility and treatment. Annual Review of Pharmacology and Toxicology. 50: 39-61. PMID 20055697 DOI: 10.1146/Annurev.Pharmtox.010909.105826  0.732
2010 Zawertailo LA, Tyndale RF, Busto U, Sellers EM. Effect of metabolic blockade on the psychoactive effects of dextromethorphan. Human Psychopharmacology. 25: 71-9. PMID 20041473 DOI: 10.1002/Hup.1086  0.368
2010 Grieder TE, Sellings LH, Vargas-Perez H, Ting-A-Kee R, Siu EC, Tyndale RF, van der Kooy D. Dopaminergic signaling mediates the motivational response underlying the opponent process to chronic but not acute nicotine. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 35: 943-54. PMID 20032966 DOI: 10.1038/Npp.2009.198  0.413
2010 Al Koudsi N, Hoffmann EB, Assadzadeh A, Tyndale RF. Hepatic CYP2A6 levels and nicotine metabolism: impact of genetic, physiological, environmental, and epigenetic factors. European Journal of Clinical Pharmacology. 66: 239-51. PMID 20012030 DOI: 10.1007/S00228-009-0762-0  0.416
2010 Koudsi NA, O'Loughlin J, Rodriguez D, Audrain-McGovern J, Tyndale RF. The genetic aspects of nicotine metabolism and their impact on adolescent nicotine dependence Journal of Pediatric Biochemistry. 1: 105-123. DOI: 10.3233/JPB-2010-0014  0.311
2009 Ho MK, Faseru B, Choi WS, Nollen NL, Mayo MS, Thomas JL, Okuyemi KS, Ahluwalia JS, Benowitz NL, Tyndale RF. Utility and relationships of biomarkers of smoking in African-American light smokers. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 18: 3426-34. PMID 19959692 DOI: 10.1158/1055-9965.Epi-09-0956  0.683
2009 Thomas PD, Mi H, Swan GE, Lerman C, Benowitz N, Tyndale RF, Bergen AW, Conti DV. A systems biology network model for genetic association studies of nicotine addiction and treatment. Pharmacogenetics and Genomics. 19: 538-51. PMID 19525886 DOI: 10.1097/Fpc.0B013E32832E2Ced  0.374
2009 Al Koudsi N, Ahluwalia JS, Lin SK, Sellers EM, Tyndale RF. A novel CYP2A6 allele (CYP2A6*35) resulting in an amino-acid substitution (Asn438Tyr) is associated with lower CYP2A6 activity in vivo. The Pharmacogenomics Journal. 9: 274-82. PMID 19365400 DOI: 10.1038/Tpj.2009.11  0.363
2009 Swan GE, Lessov-Schlaggar CN, Bergen AW, He Y, Tyndale RF, Benowitz NL. Genetic and environmental influences on the ratio of 3'hydroxycotinine to cotinine in plasma and urine. Pharmacogenetics and Genomics. 19: 388-98. PMID 19300303 DOI: 10.1097/Fpc.0B013E32832A404F  0.393
2009 Yue J, Khokhar J, Miksys S, Tyndale RF. Differential induction of ethanol-metabolizing CYP2E1 and nicotine-metabolizing CYP2B1/2 in rat liver by chronic nicotine treatment and voluntary ethanol intake. European Journal of Pharmacology. 609: 88-95. PMID 19285975 DOI: 10.1016/J.Ejphar.2009.03.015  0.707
2009 Ho MK, Mwenifumbo JC, Al Koudsi N, Okuyemi KS, Ahluwalia JS, Benowitz NL, Tyndale RF. Association of nicotine metabolite ratio and CYP2A6 genotype with smoking cessation treatment in African-American light smokers. Clinical Pharmacology and Therapeutics. 85: 635-43. PMID 19279561 DOI: 10.1038/Clpt.2009.19  0.711
2009 Mwenifumbo JC, Tyndale RF. Molecular genetics of nicotine metabolism. Handbook of Experimental Pharmacology. 235-59. PMID 19184652 DOI: 10.1007/978-3-540-69248-5_9  0.472
2009 Ray R, Tyndale RF, Lerman C. Nicotine dependence pharmacogenetics: role of genetic variation in nicotine-metabolizing enzymes. Journal of Neurogenetics. 23: 252-61. PMID 19169923 DOI: 10.1080/01677060802572887  0.417
2009 Schnoll RA, Patterson F, Wileyto EP, Tyndale RF, Benowitz N, Lerman C. Nicotine metabolic rate predicts successful smoking cessation with transdermal nicotine: a validation study. Pharmacology, Biochemistry, and Behavior. 92: 6-11. PMID 19000709 DOI: 10.1016/J.Pbb.2008.10.016  0.49
2009 Miksys S, Tyndale RF. Brain drug-metabolizing cytochrome P450 enzymes are active in vivo, demonstrated by mechanism-based enzyme inhibition. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 34: 634-40. PMID 18668033 DOI: 10.1038/Npp.2008.110  0.383
2009 Desta Z, Tyndale R, Hoffmann E, Kreutz Y, Nguyen A, Flockhart D. Cytochrome P450 (CYP) 2A6 Genetic Variation Predicts Letrozole Plasma Concentrations in Postmenopausal Women with Breast Cancer. Cancer Research. 69: 5160-5160. DOI: 10.1158/0008-5472.Sabcs-09-5160  0.311
2009 Mwenifumbo JC, Sellers EM, Tyndale RF. Corrigendum to "Nicotine metabolism and CYP2A6 activity in a population of black African descent: Impact of gender and light smoking" [Drug Alcohol Depend. 89/1 (2007) 24-33] (DOI:10.1016/j.drugalcdep.2006.11.012) Drug and Alcohol Dependence. 104: 185. DOI: 10.1016/J.Drugalcdep.2009.04.004  0.365
2008 Mann A, Miksys S, Lee A, Mash DC, Tyndale RF. Induction of the drug metabolizing enzyme CYP2D in monkey brain by chronic nicotine treatment. Neuropharmacology. 55: 1147-55. PMID 18687346 DOI: 10.1016/J.Neuropharm.2008.07.017  0.687
2008 Conti DV, Lee W, Li D, Liu J, Van Den Berg D, Thomas PD, Bergen AW, Swan GE, Tyndale RF, Benowitz NL, Lerman C. Nicotinic acetylcholine receptor beta2 subunit gene implicated in a systems-based candidate gene study of smoking cessation. Human Molecular Genetics. 17: 2834-48. PMID 18593715 DOI: 10.1093/Hmg/Ddn181  0.307
2008 Patterson F, Schnoll RA, Wileyto EP, Pinto A, Epstein LH, Shields PG, Hawk LW, Tyndale RF, Benowitz N, Lerman C. Toward personalized therapy for smoking cessation: a randomized placebo-controlled trial of bupropion. Clinical Pharmacology and Therapeutics. 84: 320-5. PMID 18388868 DOI: 10.1038/Clpt.2008.57  0.401
2008 Shram MJ, Siu EC, Li Z, Tyndale RF, Lê AD. Interactions between age and the aversive effects of nicotine withdrawal under mecamylamine-precipitated and spontaneous conditions in male Wistar rats. Psychopharmacology. 198: 181-90. PMID 18385986 DOI: 10.1007/S00213-008-1115-X  0.412
2008 Mwenifumbo JC, Al Koudsi N, Ho MK, Zhou Q, Hoffmann EB, Sellers EM, Tyndale RF. Novel and established CYP2A6 alleles impair in vivo nicotine metabolism in a population of Black African descent. Human Mutation. 29: 679-88. PMID 18360915 DOI: 10.1002/Humu.20698  0.688
2008 Ho MK, Mwenifumbo JC, Zhao B, Gillam EM, Tyndale RF. A novel CYP2A6 allele, CYP2A6*23, impairs enzyme function in vitro and in vivo and decreases smoking in a population of Black-African descent. Pharmacogenetics and Genomics. 18: 67-75. PMID 18216723 DOI: 10.1097/Fpc.0B013E3282F3606E  0.694
2008 Yue J, Miksys S, Hoffmann E, Tyndale RF. Chronic nicotine treatment induces rat CYP2D in the brain but not in the liver: an investigation of induction and time course. Journal of Psychiatry & Neuroscience : Jpn. 33: 54-63. PMID 18197273  0.33
2008 Siu EC, Tyndale RF. Selegiline is a mechanism-based inactivator of CYP2A6 inhibiting nicotine metabolism in humans and mice. The Journal of Pharmacology and Experimental Therapeutics. 324: 992-9. PMID 18065502 DOI: 10.1124/Jpet.107.133900  0.48
2008 Mwenifumbo JC, Lessov-Schlaggar CN, Zhou Q, Krasnow RE, Swan GE, Benowitz NL, Tyndale RF. Identification of novel CYP2A6*1B variants: the CYP2A6*1B allele is associated with faster in vivo nicotine metabolism. Clinical Pharmacology and Therapeutics. 83: 115-21. PMID 17522595 DOI: 10.1038/sj.clpt.6100246  0.334
2007 Ring HZ, Valdes AM, Nishita DM, Prasad S, Jacob P, Tyndale RF, Swan GE, Benowitz NL. Gene-gene interactions between CYP2B6 and CYP2A6 in nicotine metabolism. Pharmacogenetics and Genomics. 17: 1007-15. PMID 18004205 DOI: 10.1097/01.Fpc.0000220560.59972.33  0.485
2007 Mwenifumbo JC, Tyndale RF. Genetic variability in CYP2A6 and the pharmacokinetics of nicotine. Pharmacogenomics. 8: 1385-402. PMID 17979512 DOI: 10.2217/14622416.8.10.1385  0.506
2007 Wall TL, Schoedel K, Ring HZ, Luczak SE, Katsuyoshi DM, Tyndale RF. Differences in pharmacogenetics of nicotine and alcohol metabolism: review and recommendations for future research. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 9: S459-74. PMID 17978975 DOI: 10.1080/14622200701587045  0.689
2007 Lee AM, Jepson C, Shields PG, Benowitz N, Lerman C, Tyndale RF. CYP2B6 genotype does not alter nicotine metabolism, plasma levels, or abstinence with nicotine replacement therapy. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 16: 1312-4. PMID 17548706 DOI: 10.1158/1055-9965.Epi-07-0188  0.465
2007 Strasser AA, Malaiyandi V, Hoffmann E, Tyndale RF, Lerman C. An association of CYP2A6 genotype and smoking topography. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 9: 511-8. PMID 17454707 DOI: 10.1080/14622200701239605  0.36
2007 Ho MK, Tyndale RF. Overview of the pharmacogenomics of cigarette smoking. The Pharmacogenomics Journal. 7: 81-98. PMID 17224913 DOI: 10.1038/sj.tpj.6500436  0.667
2007 Siu EC, Tyndale RF. Non-nicotinic therapies for smoking cessation. Annual Review of Pharmacology and Toxicology. 47: 541-64. PMID 17209799 DOI: 10.1146/Annurev.Pharmtox.47.120505.105354  0.436
2007 Mwenifumbo JC, Sellers EM, Tyndale RF. Nicotine metabolism and CYP2A6 activity in a population of black African descent: impact of gender and light smoking. Drug and Alcohol Dependence. 89: 24-33. PMID 17161559 DOI: 10.1016/J.Drugalcdep.2006.11.012  0.406
2007 Siu EC, Tyndale RF. Characterization and comparison of nicotine and cotinine metabolism in vitro and in vivo in DBA/2 and C57BL/6 mice. Molecular Pharmacology. 71: 826-34. PMID 17158199 DOI: 10.1124/Mol.106.032086  0.441
2007 Audrain-McGovern J, Al Koudsi N, Rodriguez D, Wileyto EP, Shields PG, Tyndale RF. The role of CYP2A6 in the emergence of nicotine dependence in adolescents. Pediatrics. 119: e264-74. PMID 17130279 DOI: 10.1542/Peds.2006-1583  0.454
2007 Damaj MI, Siu EC, Sellers EM, Tyndale RF, Martin BR. Inhibition of nicotine metabolism by methoxysalen: Pharmacokinetic and pharmacological studies in mice. The Journal of Pharmacology and Experimental Therapeutics. 320: 250-7. PMID 17021260 DOI: 10.1124/Jpet.106.111237  0.467
2007 Matta SG, Balfour DJ, Benowitz NL, Boyd RT, Buccafusco JJ, Caggiula AR, Craig CR, Collins AC, Damaj MI, Donny EC, Gardiner PS, Grady SR, Heberlein U, Leonard SS, Levin ED, ... ... Tyndale RF, et al. Guidelines on nicotine dose selection for in vivo research. Psychopharmacology. 190: 269-319. PMID 16896961 DOI: 10.1007/S00213-006-0441-0  0.32
2006 Benowitz NL, Swan GE, Jacob P, Lessov-Schlaggar CN, Tyndale RF. CYP2A6 genotype and the metabolism and disposition kinetics of nicotine. Clinical Pharmacology and Therapeutics. 80: 457-67. PMID 17112802 DOI: 10.1016/j.clpt.2006.08.011  0.375
2006 Malaiyandi V, Goodz SD, Sellers EM, Tyndale RF. CYP2A6 genotype, phenotype, and the use of nicotine metabolites as biomarkers during ad libitum smoking. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 15: 1812-9. PMID 17035386 DOI: 10.1158/1055-9965.Epi-05-0723  0.483
2006 Miksys S, Tyndale RF. Nicotine induces brain CYP enzymes: relevance to Parkinson's disease. Journal of Neural Transmission. Supplementum. 177-80. PMID 17017527  0.317
2006 Quik M, Parameswaran N, McCallum SE, Bordia T, Bao S, McCormack A, Kim A, Tyndale RF, Langston JW, Di Monte DA. Chronic oral nicotine treatment protects against striatal degeneration in MPTP-treated primates. Journal of Neurochemistry. 98: 1866-75. PMID 16882311 DOI: 10.1111/J.1471-4159.2006.04078.X  0.434
2006 Lee AM, Tyndale RF. Drugs and genotypes: how pharmacogenetic information could improve smoking cessation treatment. Journal of Psychopharmacology (Oxford, England). 20: 7-14. PMID 16785264 DOI: 10.1177/1359786806066039  0.436
2006 Lerman C, Tyndale R, Patterson F, Wileyto EP, Shields PG, Pinto A, Benowitz N. Nicotine metabolite ratio predicts efficacy of transdermal nicotine for smoking cessation. Clinical Pharmacology and Therapeutics. 79: 600-8. PMID 16765148 DOI: 10.1016/J.Clpt.2006.02.006  0.388
2006 Lee AM, Yue J, Tyndale RF. In vivo and in vitro characterization of chlorzoxazone metabolism and hepatic CYP2E1 levels in African Green monkeys: induction by chronic nicotine treatment. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 34: 1508-15. PMID 16763012 DOI: 10.1124/Dmd.106.010363  0.486
2006 Al Koudsi N, Mwenifumbo JC, Sellers EM, Benowitz NL, Swan GE, Tyndale RF. Characterization of the novel CYP2A6*21 allele using in vivo nicotine kinetics. European Journal of Clinical Pharmacology. 62: 481-4. PMID 16758265 DOI: 10.1007/S00228-006-0113-3  0.468
2006 Lee AM, Miksys S, Tyndale RF. Phenobarbital increases monkey in vivo nicotine disposition and induces liver and brain CYP2B6 protein. British Journal of Pharmacology. 148: 786-94. PMID 16751792 DOI: 10.1038/sj.bjp.0706787  0.387
2006 Siu EC, Wildenauer DB, Tyndale RF. Nicotine self-administration in mice is associated with rates of nicotine inactivation by CYP2A5. Psychopharmacology. 184: 401-8. PMID 16485141 DOI: 10.1007/S00213-006-0306-6  0.479
2006 Joshi M, Tyndale RF. Induction and recovery time course of rat brain CYP2E1 after nicotine treatment. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 34: 647-52. PMID 16434548 DOI: 10.1124/Dmd.105.008029  0.492
2006 McCallum SE, Parameswaran N, Bordia T, Fan H, Tyndale RF, Langston JW, McIntosh JM, Quik M. Increases in alpha4* but not alpha3*/alpha6* nicotinic receptor sites and function in the primate striatum following chronic oral nicotine treatment. Journal of Neurochemistry. 96: 1028-41. PMID 16412091 DOI: 10.1111/J.1471-4159.2005.03646.X  0.386
2006 Malaiyandi V, Lerman C, Benowitz NL, Jepson C, Patterson F, Tyndale RF. Impact of CYP2A6 genotype on pretreatment smoking behaviour and nicotine levels from and usage of nicotine replacement therapy. Molecular Psychiatry. 11: 400-9. PMID 16402128 DOI: 10.1038/Sj.Mp.4001794  0.409
2006 Joshi M, Tyndale RF. Regional and cellular distribution of CYP2E1 in monkey brain and its induction by chronic nicotine. Neuropharmacology. 50: 568-75. PMID 16368115 DOI: 10.1016/j.neuropharm.2005.11.001  0.387
2006 Lee AM, Miksys S, Palmour R, Tyndale RF. CYP2B6 is expressed in African Green monkey brain and is induced by chronic nicotine treatment. Neuropharmacology. 50: 441-50. PMID 16309716 DOI: 10.1016/J.Neuropharm.2005.10.003  0.473
2006 Tyndale RF, Sellers EM. Modifying the metabolism of nicotine as a therapeutic strategy Novartis Foundation Symposium. 275: 235-244.  0.316
2005 Al Koudsi N, Tyndale RF. Genetic influences on smoking: a brief review. Therapeutic Drug Monitoring. 27: 704-9. PMID 16404798 DOI: 10.1097/01.Ftd.0000179842.63515.C6  0.449
2005 Miksys SL, Cheung C, Gonzalez FJ, Tyndale RF. Human CYP2D6 and mouse CYP2Ds: organ distribution in a humanized mouse model. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 33: 1495-502. PMID 16033950 DOI: 10.1124/Dmd.105.005488  0.325
2005 Mwenifumbo JC, Myers MG, Wall TL, Lin SK, Sellers EM, Tyndale RF. Ethnic variation in CYP2A6*7, CYP2A6*8 and CYP2A6*10 as assessed with a novel haplotyping method. Pharmacogenetics and Genomics. 15: 189-92. PMID 15861044 DOI: 10.1097/01213011-200503000-00008  0.331
2005 Swan GE, Benowitz NL, Lessov CN, Jacob P, Tyndale RF, Wilhelmsen K. Nicotine metabolism: the impact of CYP2A6 on estimates of additive genetic influence. Pharmacogenetics and Genomics. 15: 115-25. PMID 15861035 DOI: 10.1097/01213011-200502000-00007  0.449
2005 Malaiyandi V, Sellers EM, Tyndale RF. Implications of CYP2A6 genetic variation for smoking behaviors and nicotine dependence. Clinical Pharmacology and Therapeutics. 77: 145-58. PMID 15735609 DOI: 10.1016/J.Clpt.2004.10.011  0.34
2005 Grabus SD, Martin BR, Batman AM, Tyndale RF, Sellers E, Damaj MI. Nicotine physical dependence and tolerance in the mouse following chronic oral administration. Psychopharmacology. 178: 183-92. PMID 15365686 DOI: 10.1007/S00213-004-2007-3  0.443
2005 DEMPSEY D, JACOBIII P, TYNDALE R, HOFFMANN E, BENOWITZ N. CYP2A6 genotype and toxicity of nicotine in never smokers Clinical Pharmacology & Therapeutics. 77: P4-P4. DOI: 10.1016/j.clpt.2004.11.020  0.358
2004 O'Loughlin J, Paradis G, Kim W, DiFranza J, Meshefedjian G, McMillan-Davey E, Wong S, Hanley J, Tyndale RF. Genetically decreased CYP2A6 and the risk of tobacco dependence: a prospective study of novice smokers. Tobacco Control. 13: 422-8. PMID 15564629 DOI: 10.1136/tc.2003.007070  0.308
2004 Swan GE, Benowitz NL, Jacob P, Lessov CN, Tyndale RF, Wilhelmsen K, Krasnow RE, McElroy MR, Moore SE, Wambach M. Pharmacogenetics of nicotine metabolism in twins: methods and procedures. Twin Research : the Official Journal of the International Society For Twin Studies. 7: 435-48. PMID 15527659 DOI: 10.1375/1369052042335269  0.463
2004 Schoedel KA, Hoffmann EB, Rao Y, Sellers EM, Tyndale RF. Ethnic variation in CYP2A6 and association of genetically slow nicotine metabolism and smoking in adult Caucasians. Pharmacogenetics. 14: 615-26. PMID 15475735 DOI: 10.1097/00008571-200409000-00006  0.709
2004 Dempsey D, Tutka P, Jacob P, Allen F, Schoedel K, Tyndale RF, Benowitz NL. Nicotine metabolite ratio as an index of cytochrome P450 2A6 metabolic activity. Clinical Pharmacology and Therapeutics. 76: 64-72. PMID 15229465 DOI: 10.1016/J.Clpt.2004.02.011  0.718
2004 De Luca V, Wong AH, Muller DJ, Wong GW, Tyndale RF, Kennedy JL. Evidence of association between smoking and alpha7 nicotinic receptor subunit gene in schizophrenia patients. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 29: 1522-6. PMID 15100704 DOI: 10.1038/Sj.Npp.1300466  0.412
2003 Sellers EM, Ramamoorthy Y, Zeman MV, Djordjevic MV, Tyndale RF. The effect of methoxsalen on nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism in vivo. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 5: 891-9. PMID 14668073 DOI: 10.1080/14622200310001615231  0.397
2003 Sellers EM, Tyndale RF, Fernandes LC. Decreasing smoking behaviour and risk through CYP2A6 inhibition. Drug Discovery Today. 8: 487-93. PMID 12818518 DOI: 10.1016/S1359-6446(03)02704-1  0.32
2003 Miksys S, Lerman C, Shields PG, Mash DC, Tyndale RF. Smoking, alcoholism and genetic polymorphisms alter CYP2B6 levels in human brain. Neuropharmacology. 45: 122-32. PMID 12814665 DOI: 10.1016/S0028-3908(03)00136-9  0.311
2003 Howard LA, Ahluwalia JS, Lin SK, Sellers EM, Tyndale RF. CYP2E1*1D regulatory polymorphism: association with alcohol and nicotine dependence. Pharmacogenetics. 13: 321-8. PMID 12777962 DOI: 10.1097/00008571-200306000-00003  0.658
2003 Zhang W, Ramamoorthy Y, Tyndale RF, Sellers EM. Interaction of buprenorphine and its metabolite norbuprenorphine with cytochromes p450 in vitro. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 31: 768-72. PMID 12756210 DOI: 10.1124/Dmd.31.6.768  0.373
2003 Micu AL, Miksys S, Sellers EM, Koop DR, Tyndale RF. Rat hepatic CYP2E1 is induced by very low nicotine doses: an investigation of induction, time course, dose response, and mechanism. The Journal of Pharmacology and Experimental Therapeutics. 306: 941-7. PMID 12750430 DOI: 10.1124/Jpet.103.052183  0.46
2003 Howard LA, Miksys S, Hoffmann E, Mash D, Tyndale RF. Brain CYP2E1 is induced by nicotine and ethanol in rat and is higher in smokers and alcoholics. British Journal of Pharmacology. 138: 1376-86. PMID 12711639 DOI: 10.1038/Sj.Bjp.0705146  0.652
2003 Schoedel KA, Tyndale RF. Induction of nicotine-metabolizing CYP2B1 by ethanol and ethanol-metabolizing CYP2E1 by nicotine: summary and implications. Biochimica Et Biophysica Acta. 1619: 283-90. PMID 12573488 DOI: 10.1016/S0304-4165(02)00487-7  0.725
2003 Schoedel KA, Sellers EM, Palmour R, Tyndale RF. Down-regulation of hepatic nicotine metabolism and a CYP2A6-like enzyme in African green monkeys after long-term nicotine administration. Molecular Pharmacology. 63: 96-104. PMID 12488541 DOI: 10.1124/Mol.63.1.96  0.741
2002 Ahijevych KL, Tyndale RF, Dhatt RK, Weed HG, Browning KK. Factors influencing cotinine half-life during smoking abstinence in African American and Caucasian women. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 4: 423-31. PMID 12521401 DOI: 10.1080/1462220021000018452  0.375
2002 Goodz SD, Tyndale RF. Genotyping human CYP2A6 variants. Methods in Enzymology. 357: 59-69. PMID 12424898 DOI: 10.1016/S0076-6879(02)57666-7  0.433
2002 Xu C, Goodz S, Sellers EM, Tyndale RF. CYP2A6 genetic variation and potential consequences. Advanced Drug Delivery Reviews. 54: 1245-56. PMID 12406643 DOI: 10.1016/S0169-409X(02)00065-0  0.327
2002 Ramamoorthy Y, Yu AM, Suh N, Haining RL, Tyndale RF, Sellers EM. Reduced (+/-)-3,4-methylenedioxymethamphetamine ("Ecstasy") metabolism with cytochrome P450 2D6 inhibitors and pharmacogenetic variants in vitro. Biochemical Pharmacology. 63: 2111-9. PMID 12110370 DOI: 10.1016/S0006-2952(02)01028-6  0.369
2002 Zhang W, Ramamoorthy Y, Tyndale RF, Glick SD, Maisonneuve IM, Kuehne ME, Sellers EM. Metabolism of 18-methoxycoronaridine, an ibogaine analog, to 18-hydroxycoronaridine by genetically variable CYP2C19. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 30: 663-9. PMID 12019193 DOI: 10.1124/Dmd.30.6.663  0.346
2002 Howard LA, Sellers EM, Tyndale RF. The role of pharmacogenetically-variable cytochrome P450 enzymes in drug abuse and dependence. Pharmacogenomics. 3: 185-99. PMID 11972441 DOI: 10.1517/14622416.3.2.185  0.637
2002 Tyndale RF, Sellers EM. Genetic variation in CYP2A6-mediated nicotine metabolism alters smoking behavior. Therapeutic Drug Monitoring. 24: 163-71. PMID 11805739 DOI: 10.1097/00007691-200202000-00026  0.489
2001 Mash DC, Kovera CA, Pablo J, Tyndale R, Ervin FR, Kamlet JD, Hearn WL. Ibogaine in the treatment of heroin withdrawal. The Alkaloids. Chemistry and Biology. 56: 155-71. PMID 11705106 DOI: 10.1016/S0099-9598(01)56012-5  0.302
2001 Howard LA, Micu AL, Sellers EM, Tyndale RF. Low doses of nicotine and ethanol induce CYP2E1 and chlorzoxazone metabolism in rat liver. The Journal of Pharmacology and Experimental Therapeutics. 299: 542-50. PMID 11602665  0.682
2001 Schoedel KA, Sellers EM, Tyndale RF. Induction of CYP2B1/2 and nicotine metabolism by ethanol in rat liver but not rat brain. Biochemical Pharmacology. 62: 1025-36. PMID 11597571 DOI: 10.1016/S0006-2952(01)00744-4  0.714
2001 Ramamoorthy Y, Tyndale RF, Sellers EM. Cytochrome P450 2D6.1 and cytochrome P450 2D6.10 differ in catalytic activity for multiple substrates. Pharmacogenetics. 11: 477-87. PMID 11505218 DOI: 10.1097/00008571-200108000-00003  0.354
2001 Petrie J, Sapp DW, Tyndale RF, Park MK, Fanselow M, Olsen RW. Altered gabaa receptor subunit and splice variant expression in rats treated with chronic intermittent ethanol. Alcoholism, Clinical and Experimental Research. 25: 819-28. PMID 11410716 DOI: 10.1111/J.1530-0277.2001.Tb02285.X  0.672
2001 Tyndale RF, Sellers EM. Variable CYP2A6-mediated nicotine metabolism alters smoking behavior and risk. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 29: 548-52. PMID 11259349  0.392
2001 Wong JM, Harper PA, Meyer UA, Bock KW, Morike K, Lagueux J, Ayotte P, Tyndale RF, Sellers EM, Manchester DK, Okey AB. Ethnic variability in the allelic distribution of human aryl hydrocarbon receptor codon 554 and assessment of variant receptor function in vitro. Pharmacogenetics. 11: 85-94. PMID 11207035 DOI: 10.1097/00008571-200102000-00010  0.306
2001 BENOWITZ N, GRIFFIN C, TYNDALE R. Deficient C-oxidation of nicotine continued Clinical Pharmacology & Therapeutics. 70: 561-566. DOI: 10.1016/S0009-9236(01)90120-1  0.348
2000 Rao Y, Hoffmann E, Zia M, Bodin L, Zeman M, Sellers EM, Tyndale RF. Duplications and defects in the CYP2A6 gene: identification, genotyping, and in vivo effects on smoking. Molecular Pharmacology. 58: 747-55. PMID 10999944 DOI: 10.1124/Mol.58.4.747  0.333
2000 Sellers EM, Kaplan HL, Tyndale RF. Inhibition of cytochrome P450 2A6 increases nicotine's oral bioavailability and decreases smoking. Clinical Pharmacology and Therapeutics. 68: 35-43. PMID 10945314 DOI: 10.1067/Mcp.2000.107651  0.386
2000 Miksys S, Rao Y, Sellers EM, Kwan M, Mendis D, Tyndale RF. Regional and cellular distribution of CYP2D subfamily members in rat brain. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 30: 547-64. PMID 10923858 DOI: 10.1080/004982500406390  0.333
2000 Kathiramalainathan K, Kaplan HL, Romach MK, Busto UE, Li NY, Säwe J, Tyndale RF, Sellers EM. Inhibition of cytochrome P450 2D6 modifies codeine abuse liability. Journal of Clinical Psychopharmacology. 20: 435-44. PMID 10917405 DOI: 10.1097/00004714-200008000-00008  0.317
2000 Sellers EM, Tyndale RF. Mimicking gene defects to treat drug dependence. Annals of the New York Academy of Sciences. 909: 233-46. PMID 10911933 DOI: 10.1111/J.1749-6632.2000.Tb06685.X  0.422
2000 Miksys S, Hoffmann E, Tyndale RF. Regional and cellular induction of nicotine-metabolizing CYP2B1 in rat brain by chronic nicotine treatment. Biochemical Pharmacology. 59: 1501-11. PMID 10799646  0.388
2000 Romach MK, Otton SV, Somer G, Tyndale RF, Sellers EM. Cytochrome P450 2D6 and treatment of codeine dependence. Journal of Clinical Psychopharmacology. 20: 43-5. PMID 10653207 DOI: 10.1097/00004714-200002000-00008  0.336
1999 Tyndale RF, Pianezza ML, Sellers EM. A common genetic defect in nicotine metabolism decreases risk for dependence and lowers cigarette consumption. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 1: S63-7; discussion S6. PMID 11768189 DOI: 10.1080/14622299050011831  0.498
1999 Ozdemir V, Tyndale RF, Reed K, Herrmann N, Sellers EM, Kalow W, Naranjo CA. Paroxetine steady-state plasma concentration in relation to CYP2D6 genotype in extensive metabolizers. Journal of Clinical Psychopharmacology. 19: 472-5. PMID 10505591 DOI: 10.1097/00004714-199910000-00014  0.564
1999 TYNDALE R, LI Y, KAPLAN H, SELLERS E. Inhibition of nicotine's metabolism: A potential new treatment for tobacco dependence1 Clinical Pharmacology & Therapeutics. 65: 145-145. DOI: 10.1016/S0009-9236(99)80112-X  0.33
1998 Zawertailo LA, Kaplan HL, Busto UE, Tyndale RF, Sellers EM. Psychotropic effects of dextromethorphan are altered by the CYP2D6 polymorphism: a pilot study. Journal of Clinical Psychopharmacology. 18: 332-7. PMID 9690700 DOI: 10.1097/00004714-199808000-00014  0.353
1998 Pianezza ML, Sellers EM, Tyndale RF. Nicotine metabolism defect reduces smoking. Nature. 393: 750. PMID 9655391 DOI: 10.1038/31623  0.39
1997 Tyndale RF, Bhave SV, Hoffmann E, Hoffmann PL, Tabakoff B, Tobin AJ, Olsen RW. Pentobarbital decreases the gamma-aminobutyric acidA receptor subunit gamma-2 long/short mRNA ratio by a mechanism distinct from receptor occupation. The Journal of Pharmacology and Experimental Therapeutics. 283: 350-7. PMID 9336343  0.617
1997 Messina ES, Tyndale RF, Sellers EM. A major role for CYP2A6 in nicotine C-oxidation by human liver microsomes. The Journal of Pharmacology and Experimental Therapeutics. 282: 1608-14. PMID 9316878  0.361
1995 Greger V, Knoll JH, Woolf E, Glatt K, Tyndale RF, DeLorey TM, Olsen RW, Tobin AJ, Sikela JM, Nakatsu Y. The gamma-aminobutyric acid receptor gamma 3 subunit gene (GABRG3) is tightly linked to the alpha 5 subunit gene (GABRA5) on human chromosome 15q11-q13 and is transcribed in the same orientation. Genomics. 26: 258-64. PMID 7601451 DOI: 10.1016/0888-7543(95)80209-5  0.747
1994 Tyndale RF, Hales TG, Olsen RW, Tobin AJ. Distinctive patterns of GABAA receptor subunit mRNAs in 13 cell lines. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 5417-28. PMID 8083745 DOI: 10.1523/Jneurosci.14-09-05417.1994  0.62
1994 Tyndale R, Hales T, Olsen R, Tobin A. Distinctive patterns of GABAA receptor subunit mRNAs in 13 cell lines The Journal of Neuroscience. 14: 5417-5428. DOI: 10.1523/JNEUROSCI.14-09-05417.1994  0.605
1993 Nakatsu Y, Tyndale RF, DeLorey TM, Durham-Pierre D, Gardner JM, McDanel HJ, Nguyen Q, Wagstaff J, Lalande M, Sikela JM. A cluster of three GABAA receptor subunit genes is deleted in a neurological mutant of the mouse p locus. Nature. 364: 448-50. PMID 8392662 DOI: 10.1038/364448a0  0.663
1991 Tyndale RF, Kalow W, Inaba T. Oxidation of reduced haloperidol to haloperidol: involvement of human P450IID6 (sparteine/debrisoquine monooxygenase). British Journal of Clinical Pharmacology. 31: 655-60. PMID 1867960 DOI: 10.1111/J.1365-2125.1991.Tb05588.X  0.562
1991 Tyndale R, Aoyama T, Broly F, Matsunaga T, Inaba T, Kalow W, Gelboin HV, Meyer UA, Gonzalez FJ. Identification of a new variant CYP2D6 allele lacking the codon encoding Lys-281: possible association with the poor metabolizer phenotype. Pharmacogenetics. 1: 26-32. PMID 1844820 DOI: 10.1097/00008571-199110000-00005  0.609
1990 Tyndale RF, Gonzalez FJ, Hardwick JP, Kalow W, Inaba T. Sparteine metabolism capacity in human liver: structural variants of human P450IID6 as assessed by immunochemistry. Pharmacology & Toxicology. 67: 14-8. PMID 2395811 DOI: 10.1111/J.1600-0773.1990.Tb00774.X  0.593
1990 Niznik HB, Tyndale RF, Sallee FR, Gonzalez FJ, Hardwick JP, Inaba T, Kalow W. The dopamine transporter and cytochrome P45OIID1 (debrisoquine 4-hydroxylase) in brain: resolution and identification of two distinct [3H]GBR-12935 binding proteins. Archives of Biochemistry and Biophysics. 276: 424-32. PMID 2306106 DOI: 10.1016/0003-9861(90)90741-G  0.508
1990 Inaba T, Tyndale RF, Niznik HB, Kalow W. Cytochrome p45 0IID6 (debrisoquine hydroxylase): inhibition studies in liver and brain European Journal of Pharmacology. 183: 661. DOI: 10.1016/0014-2999(90)92448-R  0.578
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