Sascha Weggen, Dr. rer. nat. - Related publications

Neuropathology University of Duesseldof 
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50 most relevant papers in past 60 days:
Year Citation  Score
2020 Mazinani N, Strilchuk AW, Baylis JR, Hur WS, Jefferies WA, Kastrup CJ. Bleeding is increased in amyloid precursor protein knockout mouse. Research and Practice in Thrombosis and Haemostasis. 4: 823-828. PMID 32685890 DOI: 10.1002/rth2.12375   
2020 Gericke C, Mallone A, Engelhardt B, Nitsch RM, Ferretti MT. Oligomeric Forms of Human Amyloid-Beta(1-42) Inhibit Antigen Presentation. Frontiers in Immunology. 11: 1029. PMID 32582162 DOI: 10.3389/fimmu.2020.01029   
2020 Farkhondeh T, Khan H, Aschner M, Samini F, Pourbagher-Shahri AM, Aramjoo H, Roshanravan B, Hoyte C, Mehrpour O, Samarghandian S. Impact of Cannabis-Based Medicine on Alzheimer's disease by Focusing on the Amyloid β- Modifications: A Systematic Study. Cns & Neurological Disorders Drug Targets. PMID 32640965 DOI: 10.2174/1871527319666200708130745   
2020 Liang Y, Raven F, Ward JF, Zhen S, Zhang S, Sun H, Miller SJ, Choi SH, Tanzi RE, Zhang C. Upregulation of Alzheimer's Disease Amyloid-β Protein Precursor in Astrocytes Both in vitro and in vivo. Journal of Alzheimer's Disease : Jad. PMID 32597805 DOI: 10.3233/JAD-200128   
2020 Wu PF, Bhore N, Lee YL, Chou JY, Chen YW, Wu PY, Hsu WM, Lee H, Huang YS, Lu PJ, Liao YF. Phosphatidylinositol-4-phosphate 5-kinase type 1α attenuates Aβ production by promoting non-amyloidogenic processing of amyloid precursor protein. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 32686865 DOI: 10.1096/fj.202000113R   
2020 Stefanescu R, Stanciu GD, Luca A, Paduraru L, Tamba BI. Secondary Metabolites from Plants Possessing Inhibitory Properties against Beta-Amyloid Aggregation as Revealed by Thioflavin-T Assay and Correlations with Investigations on Transgenic Mouse Models of Alzheimer's Disease. Biomolecules. 10. PMID 32517180 DOI: 10.3390/biom10060870   
2020 Iqbal UH, Zeng E, Pasinetti GM. The Use of Antimicrobial and Antiviral Drugs in Alzheimer's Disease. International Journal of Molecular Sciences. 21. PMID 32664669 DOI: 10.3390/ijms21144920   
2020 Jangampalli Adi Pradeepkiran, Arubala P Reddy, Xiangling Yin, Maria Manczak, P Hemachandra Reddy. Protective effects of BACE1 inhibitory ligand molecules against amyloid beta-induced synaptic and mitochondrial toxicities in Alzheimer’s disease Human Molecular Genetics. 29: 49-69. PMID 31595293 DOI: 10.1093/hmg/ddz227   
2020 Cone AS, Hurwitz SN, Lee GS, Yuan X, Zhou Y, Li Y, Meckes DG. Alix and Syntenin-1 direct amyloid precursor protein trafficking into extracellular vesicles. Bmc Molecular and Cell Biology. 21: 58. PMID 32731849 DOI: 10.1186/s12860-020-00302-0   
2020 Jia L, Wang W, Yan Y, Hu R, Sang J, Zhao W, Wang Y, Wei W, Cui W, Yang G, Lu F, Zheng J, Liu F. General Aggregation-Induced Emission Probes for Amyloid Inhibitors with Dual Inhibition Capacity against Amyloid β-Protein and α-Synuclein. Acs Applied Materials & Interfaces. PMID 32584021 DOI: 10.1021/acsami.0c07745   
2020 Liu M, Qian T, Zhou W, Tao X, Sang S, Zhao L. Beneficial effects of low-dose lithium on cognitive ability and pathological alteration of Alzheimer's disease transgenic mice model. Neuroreport. PMID 32639272 DOI: 10.1097/WNR.0000000000001499   
2020 Almeida ZL, Brito RMM. Structure and Aggregation Mechanisms in Amyloids. Molecules (Basel, Switzerland). 25. PMID 32155822 DOI: 10.3390/molecules25051195   
2020 Vemula PK, Jing Y, Cicolini J, Zhang H, Mockett BG, Abraham WC, Liu P. Altered brain arginine metabolism with age in the APP/PSEN1 mouse model of Alzheimer's disease. Neurochemistry International. 104798. PMID 32711019 DOI: 10.1016/j.neuint.2020.104798   
2020 Taylor X, Cisternas P, You Y, You Y, Xiang S, Marambio Y, Zhang J, Vidal R, Lasagna-Reeves CA. A1 reactive astrocytes and a loss of TREM2 are associated with an early stage of pathology in a mouse model of cerebral amyloid angiopathy. Journal of Neuroinflammation. 17: 223. PMID 32711525 DOI: 10.1186/s12974-020-01900-7   
2020 Teppang KL, Ehrlich RS, Yang J. Method to discriminate amyloids using fluorescent probes. Methods in Enzymology. 639: 91-114. PMID 32475414 DOI: 10.1016/bs.mie.2020.04.010   
2020 Mamun AA, Uddin MS, Bin Bashar MF, Zaman S, Begum Y, Bulbul IJ, Islam MS, Sarwar MS, Mathew B, Amran MS, Md Ashraf G, Bin-Jumah MN, Mousa SA, Abdel-Daim MM. Molecular Insight into the Therapeutic Promise of Targeting for Alzheimer's Disease. Oxidative Medicine and Cellular Longevity. 2020: 5086250. PMID 32509144 DOI: 10.1155/2020/5086250   
2020 Bhattarai A, Devkota S, Bhattarai S, Wolfe MS, Miao Y. Mechanisms of γ-Secretase Activation and Substrate Processing. Acs Central Science. 6: 969-983. PMID 32607444 DOI: 10.1021/acscentsci.0c00296   
2020 Melnik A, Cappelletti V, Vaggi F, Piazza I, Tognetti M, Schwarz C, Cereghetti G, Ahmed MA, Soste M, Matlack K, de Souza N, Csikasz-Nagy A, Picotti P. Comparative analysis of the intracellular responses to disease-related aggregation-prone proteins. Journal of Proteomics. 103862. PMID 32535145 DOI: 10.1016/j.jprot.2020.103862   
2020 Dahal E, Ghammraoui B, Badano A. Feasibility of a label-free X-ray method to estimate brain amyloid load in small animals. Journal of Neuroscience Methods. 343: 108822. PMID 32574641 DOI: 10.1016/j.jneumeth.2020.108822   
2020 Resende R, Ferreira-Marques M, Moreira P, Coimbra JRM, Baptista SJ, Isidoro C, Salvador JAR, Dinis TCP, Pereira CF, Santos AE. New BACE1 Chimeric Peptide Inhibitors Selectively Prevent AβPPβ Cleavage Decreasing Amyloid-β Production and Accumulation in Alzheimer's Disease Models. Journal of Alzheimer's Disease : Jad. PMID 32597812 DOI: 10.3233/JAD-200381   
2020 Harris SS, Wolf F, De Strooper B, Busche MA. Tipping the Scales: Peptide-Dependent Dysregulation of Neural Circuit Dynamics in Alzheimer's Disease. Neuron. PMID 32579881 DOI: 10.1016/j.neuron.2020.06.005   
2020 Ennerfelt HE, Lukens JR. The role of innate immunity in Alzheimer's disease. Immunological Reviews. PMID 32588460 DOI: 10.1111/imr.12896   
2020 Léger P, Nachman E, Richter K, Tamietti C, Koch J, Burk R, Kummer S, Xin Q, Stanifer M, Bouloy M, Boulant S, Kräusslich HG, Montagutelli X, Flamand M, Nussbaum-Krammer C, et al. NSs amyloid formation is associated with the virulence of Rift Valley fever virus in mice. Nature Communications. 11: 3281. PMID 32612175 DOI: 10.1038/s41467-020-17101-y   
2020 Ferreira S, Pitman KA, Wang S, Summers BS, Bye N, Young KM, Cullen CL. Amyloidosis is associated with thicker myelin and increased oligodendrogenesis in the adult mouse brain. Journal of Neuroscience Research. PMID 32557778 DOI: 10.1002/jnr.24672   
2020 Chen Y, Fang L, Chen S, Zhou H, Fan Y, Lin L, Li J, Xu J, Chen Y, Ma Y, Chen Y. Gut Microbiome Alterations Precede Cerebral Amyloidosis and Microglial Pathology in a Mouse Model of Alzheimer's Disease. Biomed Research International. 2020: 8456596. PMID 32596386 DOI: 10.1155/2020/8456596   
2020 Sae-Lee W, Scott LL, Brose L, Encarnacion AJ, Shi T, Kore P, Oyibo LO, Ye C, Rozmiarek SK, Pierce JT. APP-induced Patterned Neurodegeneration Exacerbated by in . G3 (Bethesda, Md.). PMID 32580938 DOI: 10.1534/g3.120.401486   
2020 Li W, Li Y, Gan L, Ma F, Zhang S, Wen T. Dcf1 alleviates C99-mediated deficits in drosophila by reducing the cleavage of C99. Biochemical and Biophysical Research Communications. PMID 32540098 DOI: 10.1016/j.bbrc.2020.05.063   
2020 Shah AF, Morris JA, Wray M. Pathogenesis of Alzheimer's disease: Multiple interacting causes against which amyloid precursor protein protects. Medical Hypotheses. 143: 110035. PMID 32652427 DOI: 10.1016/j.mehy.2020.110035   
2020 Pérez-Areales FJ, Garrido M, Aso E, Bartolini M, De Simone A, Espargaro A, Ginex T, Sabaté R, Pérez B, Andrisano V, Puigoriol-Illamola D, Pallàs M, Luque FJ, Loza MI, Brea JM, et al. Centrally Active Multitarget Anti-Alzheimer Agents Derived from the Antioxidant Lead CR-6. Journal of Medicinal Chemistry. PMID 32706255 DOI: 10.1021/acs.jmedchem.0c00528   
2020 Kaur J, Giri A, Bhattacharya M. The protein-surfactant stoichiometry governs the conformational switching and amyloid nucleation kinetics of tau K18. European Biophysics Journal : Ebj. PMID 32691116 DOI: 10.1007/s00249-020-01447-8   
2020 Singh M, Singh SP, Dubey PK, Rachana R, Mani S, Yadav D, Agarwal M, Agarwal S, Agarwal V, Kaur H. Advent of Proteomic Tools For Diagnostic Biomarker Analysis in Alzheimer's Disease. Current Protein & Peptide Science. PMID 32538723 DOI: 10.2174/1389203721666200615173213   
2020 Ruiz-Arias Á, Paredes JM, Di Biase C, Cuerva JM, Giron MD, Salto R, González-Vera JA, Orte A. Seeding and Growth of β-Amyloid Aggregates upon Interaction with Neuronal Cell Membranes. International Journal of Molecular Sciences. 21. PMID 32708806 DOI: 10.3390/ijms21145035   
2020 Uddin MS, Kabir MT, Al Mamun A, Behl T, Mansouri RA, Aloqbi AA, Perveen A, Hafeez A, Ashraf GM. Exploring Potential of Alkaloidal Phytochemicals Targeting Neuroinflammatory Signaling of Alzheimer's Disease. Current Pharmaceutical Design. PMID 32473620 DOI: 10.2174/1381612826666200531151004   
2020 Hammes J, Bischof GN, Bohn KP, Onur O, Schneider A, Fliessbach K, Hoenig MC, Jessen F, Neumaier B, Drzezga AE, van Eimeren T. One stop shop: Flortaucipir PET differentiates amyloid positive and negative forms of neurodegenerative diseases. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PMID 32620704 DOI: 10.2967/jnumed.120.244061   
2020 Henríquez G, Mendez L, Schmid AN, Guerrero ED, Collins SA, Castañeda E, Narayan M. Testing Amyloid Cross-Toxicity in the Vertebrate Brain. Acs Omega. 5: 15586-15591. PMID 32637834 DOI: 10.1021/acsomega.0c01819   
2020 Gillet JN. Alzheimer's disease: unraveling APOE4 binding to amyloid-beta peptide and lipids with molecular dynamics and quantum mechanics. Journal of Biomolecular Structure & Dynamics. 1-7. PMID 32580638 DOI: 10.1080/07391102.2020.1784287   
2020 Pravin N, Kumar R, Tripathi S, Kumar P, Mohite GM, Navalkar A, Panigrahi R, Singh N, Gadhe LG, Manchanda S, Shimozawa M, Nilsson P, Johansson J, Kumar A, Maji SK, et al. Benzimidazole based fluorophores for the detection of amyloid fibrils with higher sensitivity than Thioflavin-T. Journal of Neurochemistry. PMID 32750740 DOI: 10.1111/jnc.15138   
2020 Bucciantini M, Leri M, Stefani M, Melki R, Zecchi-Orlandini S, Nosi D. The Amphipathic GM1 Molecule Stabilizes Amyloid Aggregates, Preventing their Cytotoxicity. Biophysical Journal. PMID 32579964 DOI: 10.1016/j.bpj.2020.06.005   
2020 Christensen A, Pike CJ. Staining and Quantification of β-Amyloid Pathology in Transgenic Mouse Models of Alzheimer's Disease. Methods in Molecular Biology (Clifton, N.J.). 2144: 211-221. PMID 32410038 DOI: 10.1007/978-1-0716-0592-9_19   
2020 Lee YF, Gerashchenko D, Timofeev I, Bacskai BJ, Kastanenka KV. Slow Wave Sleep Is a Promising Intervention Target for Alzheimer's Disease. Frontiers in Neuroscience. 14: 705. PMID 32714142 DOI: 10.3389/fnins.2020.00705   
2020 Wu Q, Wang B, Li QF, Zhang X, Ntim M, Wu XF, Li N, Zhu DD, Jiang R, Yang JY, Yuan YH, Li S. SRC-1 Knockout Exerts No Effect on Amyloid β Deposition in APP/PS1 Mice. Frontiers in Aging Neuroscience. 12: 145. PMID 32625077 DOI: 10.3389/fnagi.2020.00145   
2020 Wang J, Sun BL, Xiang Y, Tian DY, Zhu C, Li WW, Liu YH, Bu XL, Shen LL, Jin WS, Wang Z, Zeng GH, Xu W, Chen LY, Chen XW, et al. Capsaicin consumption reduces brain amyloid-beta generation and attenuates Alzheimer's disease-type pathology and cognitive deficits in APP/PS1 mice. Translational Psychiatry. 10: 230. PMID 32661266 DOI: 10.1038/s41398-020-00918-y   
2020 Lv L, Yang F, Li H, Yuan J. Brain-targeted co-delivery of β-amyloid converting enzyme 1 shRNA and epigallocatechin-3-gallate by multifunctional nanocarriers for Alzheimer's disease treatment. Iubmb Life. PMID 32668504 DOI: 10.1002/iub.2330   
2020 Shepherd CE, Affleck AJ, Bahar AY, Carew-Jones F, Gregory G, Small DH, Halliday GM. Alzheimer's amyloid-β and tau protein accumulation is associated with decreased expression of the LDL receptor-associated protein in human brain tissue. Brain and Behavior. e01672. PMID 32484608 DOI: 10.1002/brb3.1672   
2020 Kim KH, Seo JD, Kim ES, Kim HS, Jeon S, Pak K, Lee MJ, Lee JH, Lee YM, Lee K, Shin JH, Ko JK, Jung NY, Lee JM, Yoon JA, et al. Comparison of Amyloid in Cerebrospinal Fluid, Brain Imaging, and Autopsy in a Case of Progressive Supranuclear Palsy. Alzheimer Disease and Associated Disorders. PMID 32520735 DOI: 10.1097/WAD.0000000000000396   
2020 Rafii MS. Alzheimer's Disease in Down Syndrome: Progress in the Design and Conduct of Drug Prevention Trials. Cns Drugs. PMID 32506291 DOI: 10.1007/s40263-020-00740-6   
2020 Li D, Zhang J, Li X, Chen Y, Yu F, Liu Q. Insights into lncRNAs in Alzheimer's Disease Mechanisms. Rna Biology. PMID 32605500 DOI: 10.1080/15476286.2020.1788848   
2020 Chen Q, Tu Y, Mak S, Chen J, Lu J, Chen C, Yang X, Wang S, Wen S, Ma S, Li M, Han Y, Wah-Keung Tism K, Pi R. Discovery of a novel small molecule PT109 with multi-targeted effects against Alzheimer's disease in vitro and in vivo. European Journal of Pharmacology. 173361. PMID 32673674 DOI: 10.1016/j.ejphar.2020.173361   
2020 Park G, Nhan HS, Tyan SH, Kawakatsu Y, Zhang C, Navarro M, Koo EH. Caspase Activation and Caspase-Mediated Cleavage of APP Is Associated with Amyloid β-Protein-Induced Synapse Loss in Alzheimer's Disease. Cell Reports. 31: 107839. PMID 32610140 DOI: 10.1016/j.celrep.2020.107839   
2020 Maccioni RB, Navarrete LP, González A, González-Canacer A, Guzmán-Martínez L, Cortés N. Inflammation: A Major Target for Compounds to Control Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 32597798 DOI: 10.3233/JAD-191014