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Leonidas C. Platanias - Publications

Affiliations: 
Northwestern University, Evanston, IL 
Area:
Cell Biology, Oncology
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304 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Chen H, Bai Y, Kobayashi M, Xiao S, Barajas S, Cai W, Chen S, Miao J, Nguele Meke F, Yao C, Yang Y, Strube K, Satchivi O, Sun J, Ronnstrand L, ... ... Platanias LC, et al. PRL2 phosphatase promotes oncogenic KIT signaling in leukemia cells through modulating CBL phosphorylation. Molecular Cancer Research : McR. PMID 37756563 DOI: 10.1158/1541-7786.MCR-23-0115  0.43
2023 Saleiro D, Kosciuczuk EM, Fischietti M, Perez RE, Yang GS, Eckerdt F, Beauchamp EM, Hou Y, Wang Q, Weinberg RS, Fish EN, Yue F, Hoffman R, Platanias LC. Targeting CHAF1B Enhances IFN Activity against Myeloproliferative Neoplasm Cells. Cancer Research Communications. 3: 943-951. PMID 37377894 DOI: 10.1158/2767-9764.CRC-23-0010  0.392
2023 Mazewski C, Platanias LC. MNK Proteins as Therapeutic Targets in Leukemia. Oncotargets and Therapy. 16: 283-295. PMID 37113687 DOI: 10.2147/OTT.S370874  0.337
2022 Fenton SE, Zannikou M, Ilut L, Fischietti M, Ji C, Oku CV, Horvath CM, Le Poole IC, Bosenberg M, Bartom ET, Kocherginsky M, Platanias LC, Saleiro D. Targeting ULK1 decreases interferon-γ-mediated resistance to immune checkpoint inhibitors. Molecular Cancer Research : McR. PMID 36573964 DOI: 10.1158/1541-7786.MCR-22-0684  0.322
2022 Fischietti M, Eckerdt F, Perez RE, Guillen Magaña JN, Mazewski C, Ho S, Gonzalez C, Streich LD, Beauchamp EM, Heimberger AB, Baran AH, Yue F, James CD, Platanias LC. SLFN11 negatively regulates non-canonical NFkB signaling to promote glioblastoma progression. Cancer Research Communications. 2: 966-978. PMID 36382088 DOI: 10.1158/2767-9764.crc-22-0192  0.319
2022 Chen H, Bai Y, Kobayashi M, Xiao S, Cai W, Barajas S, Chen S, Miao J, Nguele Meke F, Vemula S, Ropa J, Croop J, Boswell HS, Wan J, Jia Y, ... ... Platanias LC, et al. PRL2 phosphatase enhances oncogenic FLT3 signaling via dephosphorylation of the E3 ubiquitin ligase CBL at tyrosine 371. Blood. PMID 36206490 DOI: 10.1182/blood.2022016580  0.401
2022 Perez RE, Saleiro D, Ilut L, Schiltz GE, Eckerdt F, Fish EN, Platanias LC. Regulation of IFNα-induced expression of the short ACE2 isoform by ULK1. Molecular Immunology. 147: 1-9. PMID 35489289 DOI: 10.1016/j.molimm.2022.04.008  0.363
2022 Saleiro D, Wen JQ, Kosciuczuk EM, Eckerdt F, Beauchamp EM, Oku CV, Blyth GT, Fischietti M, Ilut L, Colamonici M, Palivos W, Atsaves PA, Tan D, Kocherginsky M, Weinberg RS, ... ... Platanias LC, et al. Discovery of a signaling feedback circuit that defines interferon responses in myeloproliferative neoplasms. Nature Communications. 13: 1750. PMID 35365653 DOI: 10.1038/s41467-022-29381-7  0.379
2021 Suarez M, Blyth GT, Mina AA, Kosciuczuk EM, Dolniak B, Dinner S, Altman JK, Eklund EA, Saleiro D, Beauchamp EM, Platanias LC. Inhibitory effects of Tomivosertib in acute myeloid leukemia. Oncotarget. 12: 955-966. PMID 34012509 DOI: 10.18632/oncotarget.27952  0.379
2020 Mazewski C, Perez RE, Fish EN, Platanias LC. Type I Interferon (IFN)-Regulated Activation of Canonical and Non-Canonical Signaling Pathways. Frontiers in Immunology. 11: 606456. PMID 33329603 DOI: 10.3389/fimmu.2020.606456  0.355
2020 Eckerdt FD, Bell JB, Gonzalez C, Oh MS, Perez RE, Mazewski C, Fischietti M, Goldman S, Nakano I, Platanias LC. Combined PI3Kα-mTOR Targeting of Glioma Stem Cells. Scientific Reports. 10: 21873. PMID 33318517 DOI: 10.1038/s41598-020-78788-z  0.354
2020 Wang H, Shah CA, Hu L, Huang W, Platanias LC, Eklund EA. An aberrantly sustained emergency granulopoiesis response accelerates post chemotherapy relapse in MLL1-rearranged acute myeloid leukemia in mice. The Journal of Biological Chemistry. PMID 32467231 DOI: 10.1074/Jbc.Ra120.013206  0.448
2019 Kosciuczuk EM, Kar AK, Blyth GT, Fischietti M, Abedin S, Mina AA, Siliezar R, Rzymski T, Brzozka K, Eklund EA, Beauchamp EM, Eckerdt F, Saleiro D, Platanias LC. Inhibitory effects of SEL201 in acute myeloid leukemia. Oncotarget. 10: 7112-7121. PMID 31903169 DOI: 10.18632/Oncotarget.27388  0.565
2019 Saleiro D, Platanias LC. Interferon signaling in cancer. Non-canonical pathways and control of intracellular immune checkpoints. Seminars in Immunology. 43: 101299. PMID 31771762 DOI: 10.1016/J.Smim.2019.101299  0.391
2019 Lee-Chang C, Rashidi A, Miska J, Zhang P, Pituch KC, Hou D, Xiao T, Fischietti M, Kang SJ, Appin CL, Horbinski C, Platanias LC, Lopez-Rosas A, Han Y, Balyasnikova IV, et al. Myeloid-derived suppressive cells promote B cell-mediated immunosuppression via transfer of PD-L1 in glioblastoma. Cancer Immunology Research. PMID 31530559 DOI: 10.1158/2326-6066.Cir-19-0240  0.336
2019 Eckerdt F, Clymer J, Bell JB, Beauchamp EM, Blyth GT, Goldman S, Platanias LC. Pharmacological mTOR targeting enhances the antineoplastic effects of selective PI3Kα inhibition in medulloblastoma. Scientific Reports. 9: 12822. PMID 31492956 DOI: 10.1038/S41598-019-49299-3  0.45
2019 Mishra RK, Clutter MR, Blyth GT, Kosciuczuk EM, Blackburn AZ, Beauchamp EM, Schiltz GE, Platanias LC. Discovery of novel Mnk inhibitors using mutation-based induced-fit virtual high-throughput screening. Chemical Biology & Drug Design. PMID 31260185 DOI: 10.1111/Cbdd.13585  0.44
2019 Abedin SM, Platanias LC. Natural killer cell activity and survival after azacitidine treatment in high-risk MDS. Leukemia & Lymphoma. 1-2. PMID 31120354 DOI: 10.1080/10428194.2019.1613543  0.306
2019 Eckerdt F, Bell JB, Beauchamp EM, Clymer J, Blyth GT, Kosciuczuk EM, Ma Q, Chen DZ, Horbinski C, Goldman S, Munshi HG, Hashizume R, Platanias LC. Potent Antineoplastic Effects of Combined PI3Kα-MNK Inhibition in Medulloblastoma. Molecular Cancer Research : McR. PMID 30842251 DOI: 10.1158/1541-7786.Mcr-18-1193  0.459
2018 Brisard D, Eckerdt F, Marsh LA, Blyth GT, Jain S, Cristofanilli M, Horiuchi D, Platanias LC. Antineoplastic effects of selective CDK9 inhibition with atuveciclib on cancer stem-like cells in triple-negative breast cancer. Oncotarget. 9: 37305-37318. PMID 30647871 DOI: 10.18632/Oncotarget.26468  0.391
2018 Beauchamp EM, Abedin SM, Radecki SG, Fischietti M, Arslan AD, Blyth GT, Yang A, Lantz C, Nelson A, Goo YA, Akpan I, Eklund EA, Frankfurt O, Fish EN, Thomas PM, ... ... Platanias LC, et al. Identification and targeting of novel CDK9 complexes in acute myeloid leukemia. Blood. PMID 30587525 DOI: 10.1182/Blood-2018-08-870089  0.483
2018 Kosciuczuk EM, Mehrotra S, Saleiro D, Kroczynska B, Majchrzak-Kita B, Lisowski P, Driehaus C, Rogalska A, Turner A, Lienhoop T, Gius D, Fish EN, Vassilopoulos A, Platanias LC. Sirtuin 2-mediated deacetylation of cyclin-dependent kinase 9 promotes STAT1 signaling in type I interferon responses. The Journal of Biological Chemistry. PMID 30487288 DOI: 10.1074/Jbc.Ra118.005956  0.544
2018 Saleiro D, Blyth GT, Kosciuczuk EM, Ozark PA, Majchrzak-Kita B, Arslan AD, Fischietti M, Reddy NK, Horvath CM, Davis RJ, Fish EN, Platanias LC. IFN-γ-inducible antiviral responses require ULK1-mediated activation of MLK3 and ERK5. Science Signaling. 11. PMID 30459284 DOI: 10.1126/Scisignal.Aap9921  0.527
2018 Fischietti M, Arslan AD, Sassano A, Saleiro D, Majchrzak-Kita B, Ebine K, Munshi HG, Fish EN, Platanias LC. Slfn2 Regulates Type I Interferon Responses by Modulating the NFĸB Pathway. Molecular and Cellular Biology. PMID 29866656 DOI: 10.1128/Mcb.00053-18  0.465
2018 Lesovaya E, Agarwal S, Readhead B, Vinokour E, Baida G, Bhalla P, Kirsanov K, Yakubovskaya M, Platanias LC, Dudley JT, Budunova I. Rapamycin modulates glucocorticoid receptor function, blocks atrophogene REDD1, and protects skin from steroid atrophy. The Journal of Investigative Dermatology. PMID 29596905 DOI: 10.1016/J.Jid.2018.02.045  0.465
2018 Wang H, Bei L, Shah CA, Huang W, Platanias LC, Eklund EA. The E3 ubiquitin ligase Triad1 influences development of Mll-Ell-induced acute myeloid leukemia. Oncogene. PMID 29459712 DOI: 10.1038/S41388-018-0131-5  0.378
2018 Bell JB, Rink JS, Eckerdt F, Clymer J, Goldman S, Thaxton CS, Platanias LC. HDL nanoparticles targeting sonic hedgehog subtype medulloblastoma. Scientific Reports. 8: 1211. PMID 29352211 DOI: 10.1038/S41598-017-18100-8  0.315
2018 D. Eckerdt F, Fischietti M, Horbinski C, James CD, Platanias L. CSIG-15. SLFN5: A REPRESSOR OF INTERFERON-INDUCED SIGNALING THAT STIMULATES GLIOBLASTOMA CELL PROLIFERATION. SURVIVAL RESPONSES IN DIFFERENT XENOGRAFT GLIOBLASTOMA MOUSE MODELS Neuro-Oncology. 20: vi46-vi46. DOI: 10.1093/Neuonc/Noy148.181  0.397
2017 Bell JB, Eckerdt F, Dhruv H, Finlay D, Peng S, Kim S, Kroczynska B, Beauchamp E, Alley K, Clymer J, Goldman S, Cheng SY, James CD, Nakano I, Horbinski C, ... ... Platanias LC, et al. Differential Response of Glioma Stem Cells to Arsenic Trioxide Therapy is Regulated by MNK1 and mRNA Translation. Molecular Cancer Research : McR. PMID 29042487 DOI: 10.1158/1541-7786.Mcr-17-0397  0.453
2017 Arslan AD, Sassano A, Saleiro D, Lisowski P, Kosciuczuk EM, Fischietti M, Eckerdt F, Fish EN, Platanias LC. Human SLFN5 is a transcriptional co-repressor of STAT1-mediated interferon responses and promotes the malignant phenotype in glioblastoma. Oncogene. 36: 6006-6019. PMID 28671669 DOI: 10.1038/Onc.2017.205  0.423
2017 Gilles L, Arslan AD, Marinaccio C, Wen QJ, Arya P, McNulty M, Yang Q, Zhao JC, Konstantinoff K, Lasho T, Pardanani A, Stein B, Plo I, Sundaravel S, Wickrema A, ... ... Platanias LC, et al. Downregulation of GATA1 drives impaired hematopoiesis in primary myelofibrosis. The Journal of Clinical Investigation. PMID 28240607 DOI: 10.1172/Jci82905  0.34
2017 Kroczynska B, Blyth GT, Rafidi RL, Majchrzak-Kita B, Xu L, Saleiro D, Kosciuczuk EM, Jemielity J, Su B, Altman JK, Eklund EA, Fish EH, Platanias LC. Central Regulatory Role for SIN1 in Interferon γ (IFNγ) Signaling and Generation of Biological Responses. The Journal of Biological Chemistry. PMID 28174303 DOI: 10.1074/Jbc.M116.757666  0.531
2017 Kaplan JB, Platanias LC. Another tyrosine kinase inhibitor-resistance mutation within the BCR-ABL kinase domain: chasing our tails? Leukemia & Lymphoma. 1-5. PMID 28140710 DOI: 10.1080/10428194.2017.1283034  0.383
2017 Clymer J, Eckerd F, Bell J, Lulla R, Goldman S, Platanias L. MEDU-44. TARGETING SHH SIGNALING VIA PI3K/MTOR INHIBITION IN MEDULLOBLASTOMA AND EWING SARCOMA Neuro-Oncology. 19: iv47-iv47. DOI: 10.1093/Neuonc/Nox083.194  0.4
2016 Saleiro D, Radecki SG, Platanias LC. Mesenchymal stromal cells and Interferon α (IFNα) in cancer immunotherapy. Translational Cancer Research. 5: S1039-S1043. PMID 29264278 DOI: 10.21037/Tcr.2016.11.12  0.335
2016 Bell JB, Eckerdt F, Alley K, Magnusson LP, Hussain H, Bi Y, Arslan AD, Clymer J, Alvarez AA, Goldman S, Cheng SY, Nakano I, Horbinski C, Davuluri RV, James CD, ... Platanias LC, et al. MNK Inhibition Disrupts Mesenchymal Glioma Stem Cells and Prolongs Survival in a Mouse Model of Glioblastoma. Molecular Cancer Research : McR. PMID 27364770 DOI: 10.1158/1541-7786.Mcr-16-0172  0.423
2016 Shah CA, Bei L, Wang H, Altman JK, Platanias LC, Eklund EA. Cooperation between AlphavBeta3 integrin and the fibroblast growth factor receptor enhances proliferation of Hox-overexpressing acute myeloid leukemia cells. Oncotarget. PMID 27340869 DOI: 10.18632/Oncotarget.10189  0.436
2016 Kosciuczuk EM, Saleiro D, Kroczynska B, Beauchamp EM, Eckerdt F, Blyth GT, Abedin SM, Giles FJ, Altman JK, Platanias LC. Merestinib blocks MNK kinase activity in acute myeloid leukemia progenitors and exhibits antileukemic effects in vitro and in vivo. Blood. PMID 27307295 DOI: 10.1182/Blood-2016-02-698704  0.519
2016 Bachegowda L, Morrone K, Winski SL, Mantzaris I, Bartenstein M, Ramachandra N, Giricz O, Sukrithan V, Nwankwo G, Shahnaz S, Bhagat T, Bhattacharyya S, Assal A, Shastri A, Gordon-Mitchell S, ... ... Platanias LC, et al. Pexmetinib: a novel dual inhibitor of Tie-2 and p38 MAPK with efficacy in preclinical models of myelodysplastic syndromes and acute myeloid leukemia. Cancer Research. PMID 27287719 DOI: 10.1158/0008-5472.Can-15-3062  0.469
2016 Iqbal A, Eckerdt F, Bell J, Nakano I, Giles FJ, Cheng SY, Lulla RR, Goldman S, Platanias LC. Targeting of glioblastoma cell lines and glioma stem cells by combined PIM kinase and PI3K-p110α inhibition. Oncotarget. PMID 27120806 DOI: 10.18632/Oncotarget.8899  0.534
2016 Kosciuczuk EM, Saleiro D, Platanias LC. Dual targeting of eIF4E by blocking MNK and mTOR pathways in leukemia. Cytokine. PMID 27094611 DOI: 10.1016/J.Cyto.2016.01.024  0.54
2016 Saleiro D, Kosciuczuk EM, Platanias LC. Beyond autophagy: New roles for ULK1 in immune signaling and interferon responses. Cytokine & Growth Factor Reviews. 29: 17-22. PMID 27068414 DOI: 10.1016/J.Cytogfr.2016.03.008  0.479
2016 Dinner S, Platanias LC. Targeting the mTOR Pathway in Leukemia. Journal of Cellular Biochemistry. 117: 1745-52. PMID 27018341 DOI: 10.1002/Jcb.25559  0.555
2016 Huang W, Luan CH, Hjort EE, Bei L, Mishra R, Sakamoto KM, Platanias LC, Eklund EA. The role of Fas-associated phosphatase 1 in leukemia stem cell-persistence during tyrosine kinase inhibitor-treatment of chronic myeloid leukemia. Leukemia. PMID 26984787 DOI: 10.1038/Leu.2016.66  0.472
2016 Kaplan JB, Stein BL, McMahon B, Giles FJ, Platanias LC. Evolving Therapeutic Strategies for the Classic Philadelphia-Negative Myeloproliferative Neoplasms. Ebiomedicine. 3: 17-25. PMID 26870834 DOI: 10.1016/J.Ebiom.2016.01.010  0.325
2016 Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... Platanias LC, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12: 1-222. PMID 26799652 DOI: 10.1080/15548627.2015.1100356  0.321
2016 Bell JB, Eckerdt F, Ma Q, Clymer JR, Goldman S, Hashizume R, Platanias LC. Abstract LB-009: Mnk targeting enhances vulnerability of medulloblastoma stem-like cancer cells to PI3K-p110alpha inhibition Cancer Research. 76. DOI: 10.1158/1538-7445.Am2016-Lb-009  0.414
2016 Clymer J, Eckerdt F, Bell J, Lulla R, Goldman S, Platanias L. MB-67DUAL TARGETING OF PI3K AND mTOR SIGNALING IN MEDULLOBLASTOMA Neuro-Oncology. 18: iii112.2-iii112. DOI: 10.1093/Neuonc/Now076.63  0.448
2015 Hu L, Huang W, Hjort EE, Bei L, Platanias LC, Eklund EA. The Interferon Consensus Sequence Binding Protein (Icsbp/Irf8) is Required for Termination of Emergency Granulopoiesis. The Journal of Biological Chemistry. PMID 26683374 DOI: 10.1074/Jbc.M115.681361  0.402
2015 Kroczynska B, Rafidi RL, Majchrzak-Kita B, Kosciuczuk EM, Blyth GT, Jemielity J, Warminska Z, Saleiro D, Mehrotra S, Arslan AD, Fish EN, Platanias LC. Interferon γ (IFNγ)-Signaling via mTORC2 and Regulatory Effects in the Generation of Type II IFN Biological Responses. The Journal of Biological Chemistry. PMID 26645692 DOI: 10.1074/Jbc.M115.664995  0.39
2015 Kumar K, Chow CR, Ebine K, Arslan AD, Kwok B, Bentrem DJ, Eckerdt FD, Platanias LC, Munshi HG. Differential Regulation of ZEB1 and EMT by MAPK-interacting protein kinases (MNKs) and eIF4E in Pancreatic Cancer. Molecular Cancer Research : McR. PMID 26609108 DOI: 10.1158/1541-7786.Mcr-15-0285  0.424
2015 Harada M, Benito J, Yamamoto S, Kaur S, Arslan D, Ramirez S, Jacamo R, Platanias L, Matsushita H, Fujimura T, Kazuno S, Kojima K, Tabe Y, Konopleva M. The novel combination of dual mTOR inhibitor AZD2014 and pan-PIM inhibitor AZD1208 inhibits growth in acute myeloid leukemia via HSF pathway suppression. Oncotarget. PMID 26473447 DOI: 10.18632/Oncotarget.6122  0.516
2015 Curi DA, Beauchamp EM, Blyth GT, Arslan AD, Donato NJ, Giles FJ, Altman JK, Platanias LC. Pre-clinical evidence of PIM kinase inhibitor activity in BCR-ABL1 unmutated and mutated Philadelphia chromosome-positive (Ph+) leukemias. Oncotarget. 6: 33206-16. PMID 26375673 DOI: 10.18632/Oncotarget.5091  0.461
2015 Saleiro D, Platanias LC. ULK1 in type I interferon response. Oncotarget. 6: 24586-7. PMID 26309084 DOI: 10.18632/Oncotarget.5241  0.533
2015 Sassano A, Mavrommatis E, Arslan AD, Kroczynska B, Beauchamp EM, Khuon S, Chew TL, Green KJ, Munshi HG, Verma AK, Platanias LC. Human Schlafen 5 (SLFN5) Is a Regulator of Motility and Invasiveness of Renal Cell Carcinoma Cells. Molecular and Cellular Biology. 35: 2684-98. PMID 26012550 DOI: 10.1128/Mcb.00019-15  0.345
2015 Saleiro D, Mehrotra S, Kroczynska B, Beauchamp EM, Lisowski P, Majchrzak-Kita B, Bhagat TD, Stein BL, McMahon B, Altman JK, Kosciuczuk EM, Baker DP, Jie C, Jafari N, Thompson CB, ... ... Platanias LC, et al. Central role of ULK1 in type I interferon signaling. Cell Reports. 11: 605-17. PMID 25892232 DOI: 10.1016/J.Celrep.2015.03.056  0.517
2015 Colamonici M, Blyth G, Saleiro D, Szilard A, Bliss-Moreau M, Giles FJ, Altman JK, Beauchamp EM, Platanias LC. Dual targeting of acute myeloid leukemia progenitors by catalytic mTOR inhibition and blockade of the p110α subunit of PI3 kinase. Oncotarget. 6: 8062-70. PMID 25823922 DOI: 10.18632/Oncotarget.3509  0.525
2015 Carneiro BA, Kaplan JB, Altman JK, Giles FJ, Platanias LC. Targeting mTOR signaling pathways and related negative feedback loops for the treatment of acute myeloid leukemia. Cancer Biology & Therapy. 16: 648-56. PMID 25801978 DOI: 10.1080/15384047.2015.1026510  0.489
2015 Gupta M, Shin DM, Ramakrishna L, Goussetis DJ, Platanias LC, Xiong H, Morse HC, Ozato K. IRF8 directs stress-induced autophagy in macrophages and promotes clearance of Listeria monocytogenes. Nature Communications. 6: 6379. PMID 25775030 DOI: 10.1038/Ncomms7379  0.36
2015 Mohindra NA, Platanias LC. Catalytic mammalian target of rapamycin inhibitors as antineoplastic agents. Leukemia & Lymphoma. 56: 2518-23. PMID 25747970 DOI: 10.3109/10428194.2015.1026816  0.452
2015 Joshi S, Platanias LC. Mnk kinases in cytokine signaling and regulation of cytokine responses. Biomolecular Concepts. 6: 85. PMID 25741793 DOI: 10.1515/Bmc-2011-2000  0.774
2015 Carneiro BA, Altman JK, Kaplan JB, Ossenkoppele G, Swords R, Platanias LC, Giles FJ. Targeted therapy of acute myeloid leukemia. Expert Review of Anticancer Therapy. 15: 399-413. PMID 25623136 DOI: 10.1586/14737140.2015.1004316  0.437
2015 Saleiro D, Platanias LC. Intersection of mTOR and STAT signaling in immunity. Trends in Immunology. 36: 21-9. PMID 25592035 DOI: 10.1016/J.It.2014.10.006  0.389
2015 Kaplan JB, Platanias LC, Giles FJ. Predicting resistance to dasatinib therapy for patients with Philadelphia-positive leukemia with prior tyrosine kinase inhibitor failure. Leukemia & Lymphoma. 1-2. PMID 25535817 DOI: 10.3109/10428194.2014.999332  0.352
2015 Sakamoto KM, Grant S, Saleiro D, Crispino JD, Hijiya N, Giles F, Platanias L, Eklund EA. Targeting novel signaling pathways for resistant acute myeloid leukemia. Molecular Genetics and Metabolism. 114: 397-402. PMID 25533111 DOI: 10.1016/J.Ymgme.2014.11.017  0.403
2015 Beauchamp EM, Kosciuczuk EM, Serrano R, Nanavati D, Swindell EP, Viollet B, O'Halloran TV, Altman JK, Platanias LC. Direct binding of arsenic trioxide to AMPK and generation of inhibitory effects on acute myeloid leukemia precursors. Molecular Cancer Therapeutics. 14: 202-12. PMID 25344585 DOI: 10.1158/1535-7163.Mct-14-0665-T  0.534
2015 Bell JB, Eckerdt F, Arslan AD, Iqbal A, Alvarez AA, Cheng S, Nakano I, Platanias LC. Abstract B26: MAPK-interacting kinase inhibition sensitizes glioblastoma and glioma stem cells to arsenic trioxide Brain. 75. DOI: 10.1158/1538-7445.Brain15-B26  0.463
2015 Ozato K, Gupta M, Sarai N, Morse H, Platanias L, Xiong H, Bachu M. ID: 211 Cytokine. 76: 103. DOI: 10.1016/J.Cyto.2015.08.215  0.342
2015 Saleiro D, Kroczynska B, Mehrotra S, Verma AK, Fish EN, Platanias LC. ID: 116 Cytokine. 76: 87. DOI: 10.1016/J.Cyto.2015.08.143  0.535
2014 Eckerdt F, Goldman S, Platanias LC. New insights into malignant cell survival mechanisms in medulloblastoma. Cancer Cell & Microenvironment. 1. PMID 26097864 DOI: 10.14800/Ccm.374  0.5
2014 Joshi S, Platanias LC. Mnk kinase pathway: Cellular functions and biological outcomes. World Journal of Biological Chemistry. 5: 321-33. PMID 25225600 DOI: 10.4331/Wjbc.V5.I3.321  0.772
2014 Fish EN, Platanias LC. Interferon receptor signaling in malignancy: a network of cellular pathways defining biological outcomes. Molecular Cancer Research : McR. 12: 1691-703. PMID 25217450 DOI: 10.1158/1541-7786.Mcr-14-0450  0.473
2014 Eckerdt F, Beauchamp E, Bell J, Iqbal A, Su B, Fukunaga R, Lulla RR, Goldman S, Platanias LC. Regulatory effects of a Mnk2-eIF4E feedback loop during mTORC1 targeting of human medulloblastoma cells. Oncotarget. 5: 8442-51. PMID 25193863 DOI: 10.18632/Oncotarget.2319  0.509
2014 Kroczynska B, Mehrotra S, Majchrzak-Kita B, Arslan AD, Altman JK, Stein BL, McMahon B, Kozlowski P, Kahle PJ, Eklund EA, Fish EN, Platanias LC. Regulatory effects of SKAR in interferon α signaling and its role in the generation of type I IFN responses. Proceedings of the National Academy of Sciences of the United States of America. 111: 11377-82. PMID 25049393 DOI: 10.1073/Pnas.1405250111  0.515
2014 Mohindra NA, Giles FJ, Platanias LC. Use of mTOR inhibitors in the treatment of malignancies. Expert Opinion On Pharmacotherapy. 15: 979-90. PMID 24666371 DOI: 10.1517/14656566.2014.899582  0.444
2014 Altman JK, Szilard A, Goussetis DJ, Sassano A, Colamonici M, Gounaris E, Frankfurt O, Giles FJ, Eklund EA, Beauchamp EM, Platanias LC. Autophagy is a survival mechanism of acute myelogenous leukemia precursors during dual mTORC2/mTORC1 targeting. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 2400-9. PMID 24610825 DOI: 10.1158/1078-0432.Ccr-13-3218  0.396
2014 Kroczynska B, Mehrotra S, Arslan AD, Kaur S, Platanias LC. Regulation of interferon-dependent mRNA translation of target genes. Journal of Interferon & Cytokine Research : the Official Journal of the International Society For Interferon and Cytokine Research. 34: 289-96. PMID 24559173 DOI: 10.1089/Jir.2013.0148  0.483
2014 Wu EJ, Goussetis DJ, Beauchamp E, Kosciuczuk EM, Altman JK, Eklund EA, Platanias LC. Resveratrol enhances the suppressive effects of arsenic trioxide on primitive leukemic progenitors. Cancer Biology & Therapy. 15: 473-8. PMID 24496081 DOI: 10.4161/Cbt.27824  0.405
2014 Kaur S, Kroczynska B, Sharma B, Sassano A, Arslan AD, Majchrzak-Kita B, Stein BL, McMahon B, Altman JK, Su B, Calogero RA, Fish EN, Platanias LC. Critical roles for Rictor/Sin1 complexes in interferon-dependent gene transcription and generation of antiproliferative responses. The Journal of Biological Chemistry. 289: 6581-91. PMID 24469448 DOI: 10.1074/Jbc.M113.537852  0.779
2014 Burke JD, Platanias LC, Fish EN. Beta interferon regulation of glucose metabolism is PI3K/Akt dependent and important for antiviral activity against coxsackievirus B3. Journal of Virology. 88: 3485-95. PMID 24403577 DOI: 10.1128/Jvi.02649-13  0.408
2014 Keeton EK, McEachern K, Dillman KS, Palakurthi S, Cao Y, Grondine MR, Kaur S, Wang S, Chen Y, Wu A, Shen M, Gibbons FD, Lamb ML, Zheng X, Stone RM, ... ... Platanias LC, et al. AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia. Blood. 123: 905-13. PMID 24363397 DOI: 10.1182/Blood-2013-04-495366  0.515
2014 Shakaladevanapura Bachegowda L, Mantzaris I, Morrone KA, Keshkar N, Li W, Nwankwo G, Shahnaz S, Bhagat TD, Giricz O, Bhattacharrya S, Yu Y, Schinke CD, Pynadath A, Pellagatti A, Boultwood J, ... ... Platanias L, et al. Efficacy of Dual Inhibition of p38 Mitogen Activated Protein Kinase (MAPK) and Tie-2 Kinase in Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML) Blood. 124: 4628-4628. DOI: 10.1182/Blood.V124.21.4628.4628  0.49
2014 Gilles L, Arslan AD, Konstantinoff K, McNulty M, Terra L, Pardanani A, Stein BL, Plo I, Vainchenker W, Platanias L, Tefferi A, Crispino JD. Defect in Ribosome Biogenesis Contributes to Impaired Megakaryopoiesis in Primary Myelofibrosis Blood. 124: 4585-4585. DOI: 10.1182/Blood.V124.21.4585.4585  0.385
2014 Bei L, Shah C, Wang H, Huang W, Platanias LC, Eklund EA. Regulation of CDX4 gene transcription by HoxA9, HoxA10, the Mll-Ell oncogene and Shp2 during leukemogenesis Oncogenesis. 3. DOI: 10.1038/oncsis.2014.49  0.342
2014 Burke D, Platanias LC, Fish EN. 55 Cytokine. 70: 41. DOI: 10.1016/J.Cyto.2014.07.062  0.408
2013 Altman JK, Platanias LC. Acute myeloid leukemia: potential for new therapeutic approaches targeting mRNA translation pathways. International Journal of Hematologic Oncology. 2. PMID 24319589 DOI: 10.2217/Ijh.13.23  0.437
2013 Vakana E, Arslan AD, Szilard A, Altman JK, Platanias LC. Regulatory effects of sestrin 3 (SESN3) in BCR-ABL expressing cells. Plos One. 8: e78780. PMID 24260131 DOI: 10.1371/Journal.Pone.0078780  0.834
2013 Mavrommatis E, Arslan AD, Sassano A, Hua Y, Kroczynska B, Platanias LC. Expression and regulatory effects of murine Schlafen (Slfn) genes in malignant melanoma and renal cell carcinoma. The Journal of Biological Chemistry. 288: 33006-15. PMID 24089532 DOI: 10.1074/Jbc.M113.460741  0.37
2013 Shah CA, Bei L, Wang H, Platanias LC, Eklund EA. The leukemia-associated Mll-Ell oncoprotein induces fibroblast growth factor 2 (Fgf2)-dependent cytokine hypersensitivity in myeloid progenitor cells. The Journal of Biological Chemistry. 288: 32490-505. PMID 24089521 DOI: 10.1074/Jbc.M113.496109  0.404
2013 Kaur S, Platanias LC. IFN-β-specific signaling via a unique IFNAR1 interaction. Nature Immunology. 14: 884-5. PMID 23959176 DOI: 10.1038/Ni.2686  0.344
2013 Mehrotra S, Sharma B, Joshi S, Kroczynska B, Majchrzak B, Stein BL, McMahon B, Altman JK, Licht JD, Baker DP, Eklund EA, Wickrema A, Verma A, Fish EN, Platanias LC. Essential role for the Mnk pathway in the inhibitory effects of type I interferons on myeloproliferative neoplasm (MPN) precursors. The Journal of Biological Chemistry. 288: 23814-22. PMID 23814052 DOI: 10.1074/Jbc.M113.476192  0.85
2013 Rozen-Zvi B, Hayashida T, Hubchak SC, Hanna C, Platanias LC, Schnaper HW. TGF-β/Smad3 activates mammalian target of rapamycin complex-1 to promote collagen production by increasing HIF-1α expression. American Journal of Physiology. Renal Physiology. 305: F485-94. PMID 23761672 DOI: 10.1152/Ajprenal.00215.2013  0.334
2013 Mavrommatis E, Fish EN, Platanias LC. The schlafen family of proteins and their regulation by interferons. Journal of Interferon & Cytokine Research : the Official Journal of the International Society For Interferon and Cytokine Research. 33: 206-10. PMID 23570387 DOI: 10.1089/Jir.2012.0133  0.375
2013 Wang BX, Platanias LC, Fish EN. STAT activation in malignancies: roles in tumor progression and in the generation of antineoplastic effects of IFNs. Journal of Interferon & Cytokine Research : the Official Journal of the International Society For Interferon and Cytokine Research. 33: 181-8. PMID 23570384 DOI: 10.1089/Jir.2012.0154  0.436
2013 Nelson V, Altman JK, Platanias LC. Next generation of mammalian target of rapamycin inhibitors for the treatment of cancer. Expert Opinion On Investigational Drugs. 22: 715-22. PMID 23544840 DOI: 10.1517/13543784.2013.787066  0.419
2013 van Besien H, Sassano A, Altman JK, Platanias LC. Antileukemic properties of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. Leukemia & Lymphoma. 54: 2601-5. PMID 23540342 DOI: 10.3109/10428194.2013.790022  0.422
2013 Altman JK, Szilard A, Konicek BW, Iversen PW, Kroczynska B, Glaser H, Sassano A, Vakana E, Graff JR, Platanias LC. Inhibition of Mnk kinase activity by cercosporamide and suppressive effects on acute myeloid leukemia precursors. Blood. 121: 3675-81. PMID 23509154 DOI: 10.1182/Blood-2013-01-477216  0.832
2013 Galvin JP, Altman JK, Szilard A, Goussetis DJ, Vakana E, Sassano A, Platanias LC. Regulation of the kinase RSK1 by arsenic trioxide and generation of antileukemic responses. Cancer Biology & Therapy. 14: 411-6. PMID 23377826 DOI: 10.4161/Cbt.23760  0.837
2013 Beauchamp EM, Platanias LC. The evolution of the TOR pathway and its role in cancer Oncogene. 32: 3923-3932. PMID 23246968 DOI: 10.1038/Onc.2012.567  0.433
2013 Altman JK, Szilard AK, Platanias LC. Tyrosine kinase inhibition in acute myeloid leukemia. Leukemia & Lymphoma. 54: 1351-2. PMID 23206226 DOI: 10.3109/10428194.2012.754889  0.439
2013 Goussetis DJ, Gounaris E, Platanias LC. BCR-ABL1-induced leukemogenesis and autophagic targeting by arsenic trioxide. Autophagy. 9: 93-4. PMID 23051894 DOI: 10.4161/Auto.22259  0.415
2013 Wu EJ, Goussetis DJ, Platanias LC. Abstract 590: Enhancing effect of resveratrol on the antileukemic effects of arsenic trioxide. Cancer Research. 73: 590-590. DOI: 10.1158/1538-7445.Am2013-590  0.374
2013 Kaur S, Kroczynska B, Sharma B, Sassano A, Majchrzak B, Stein BL, McMahon B, Altman JK, Calogero R, Fish EN, Platanias LC. 140: Roles of Rictor/Sin1 complexes in IFN-generated responses Cytokine. 63: 276. DOI: 10.1016/J.Cyto.2013.06.143  0.774
2013 Burke DJ, Platanias LC, Fish EN. 31 Cytokine. 63: 250. DOI: 10.1016/J.Cyto.2013.06.034  0.468
2012 Joshi S, Platanias LC. Mnk Kinases in Cytokine Signaling and Regulation of Cytokine Responses. Biomolecular Concepts. 3: 127-139. PMID 23710261 DOI: 10.1515/bmc-2011-0057  0.781
2012 Sharma B, Joshi S, Sassano A, Majchrzak B, Kaur S, Aggarwal P, Nabet B, Bulic M, Stein BL, McMahon B, Baker DP, Fukunaga R, Altman JK, Licht JD, Fish EN, ... Platanias LC, et al. Sprouty proteins are negative regulators of interferon (IFN) signaling and IFN-inducible biological responses. The Journal of Biological Chemistry. 287: 42352-60. PMID 23074222 DOI: 10.1074/Jbc.M112.400721  0.832
2012 Goussetis DJ, Gounaris E, Wu EJ, Vakana E, Sharma B, Bogyo M, Altman JK, Platanias LC. Autophagic degradation of the BCR-ABL oncoprotein and generation of antileukemic responses by arsenic trioxide. Blood. 120: 3555-62. PMID 22898604 DOI: 10.1182/Blood-2012-01-402578  0.807
2012 Hussain AR, Ahmed SO, Ahmed M, Khan OS, Al Abdulmohsen S, Platanias LC, Al-Kuraya KS, Uddin S. Cross-talk between NFkB and the PI3-kinase/AKT pathway can be targeted in primary effusion lymphoma (PEL) cell lines for efficient apoptosis. Plos One. 7: e39945. PMID 22768179 DOI: 10.1371/Journal.Pone.0039945  0.553
2012 Beauchamp EM, Platanias LC. BH3 mimetics and multi-kinase inhibition in AML. Blood. 119: 5947-8. PMID 22730522 DOI: 10.1182/Blood-2012-04-420786  0.384
2012 Kroczynska B, Sharma B, Eklund EA, Fish EN, Platanias LC. Regulatory effects of programmed cell death 4 (PDCD4) protein in interferon (IFN)-stimulated gene expression and generation of type I IFN responses. Molecular and Cellular Biology. 32: 2809-22. PMID 22586265 DOI: 10.1128/Mcb.00310-12  0.785
2012 Frankfurt O, Platanias LC. Non-tyrosine kinase inhibitor-targeting of BCR-ABL expressing cells. Leukemia & Lymphoma. 53: 1857-8. PMID 22568509 DOI: 10.3109/10428194.2012.692089  0.48
2012 Kaur S, Sassano A, Majchrzak-Kita B, Baker DP, Su B, Fish EN, Platanias LC. Regulatory effects of mTORC2 complexes in type I IFN signaling and in the generation of IFN responses. Proceedings of the National Academy of Sciences of the United States of America. 109: 7723-8. PMID 22550181 DOI: 10.1073/Pnas.1118122109  0.52
2012 Gentzler RD, Altman JK, Platanias LC. An overview of the mTOR pathway as a target in cancer therapy. Expert Opinion On Therapeutic Targets. 16: 481-9. PMID 22494490 DOI: 10.1517/14728222.2012.677439  0.447
2012 Shah CA, Bei L, Wang H, Platanias LC, Eklund EA. HoxA10 protein regulates transcription of gene encoding fibroblast growth factor 2 (FGF2) in myeloid cells. The Journal of Biological Chemistry. 287: 18230-48. PMID 22493287 DOI: 10.1074/Jbc.M111.328401  0.454
2012 Sassano A, Altman JK, Gordon LI, Platanias LC. Statin-dependent activation of protein kinase Cδ in acute promyelocytic leukemia cells and induction of leukemic cell differentiation. Leukemia & Lymphoma. 53: 1779-84. PMID 22356114 DOI: 10.3109/10428194.2012.668287  0.528
2012 Vakana E, Altman JK, Platanias LC. Targeting AMPK in the treatment of malignancies. Journal of Cellular Biochemistry. 113: 404-9. PMID 21928327 DOI: 10.1002/Jcb.23369  0.814
2012 Yang S, Altman JK, Prachand S, Tom A, Ding B, Wu B, Platanias LC, Gordon LI. The Diterpenoid Lactone Andrographolide Induces Reactive Oxygen Species (ROS) Dependent Apoptosis in ATRA Sensitive and Resistant APL Cell Lines. Blood. 120: 2446-2446. DOI: 10.1182/Blood.V120.21.2446.2446  0.386
2012 Platanias L. I10 signaling pathways that mediate mRNA translation of ISGs and their roles in the induction of ifn responses Cytokine. 59: 493. DOI: 10.1016/J.Cyto.2012.06.300  0.485
2011 Vakana E, Platanias LC. AMPK in BCR-ABL expressing leukemias. Regulatory effects and therapeutic implications. Oncotarget. 2: 1322-8. PMID 22249159 DOI: 10.18632/Oncotarget.413  0.836
2011 Vakana E, Altman JK, Glaser H, Donato NJ, Platanias LC. Antileukemic effects of AMPK activators on BCR-ABL-expressing cells. Blood. 118: 6399-402. PMID 22021366 DOI: 10.1182/Blood-2011-01-332783  0.829
2011 Khokhar NZ, Altman JK, Platanias LC. Emerging roles for mammalian target of rapamycin inhibitors in the treatment of solid tumors and hematological malignancies. Current Opinion in Oncology. 23: 578-86. PMID 21892085 DOI: 10.1097/Cco.0B013E32834B892D  0.433
2011 Burke JD, Sonenberg N, Platanias LC, Fish EN. Antiviral effects of interferon-β are enhanced in the absence of the translational suppressor 4E-BP1 in myocarditis induced by Coxsackievirus B3. Antiviral Therapy. 16: 577-84. PMID 21685545 DOI: 10.3851/Imp1752  0.332
2011 Altman JK, Sassano A, Platanias LC. Targeting mTOR for the treatment of AML. New agents and new directions. Oncotarget. 2: 510-7. PMID 21680954 DOI: 10.18632/Oncotarget.290  0.434
2011 Sharma B, Altman JK, Goussetis DJ, Verma AK, Platanias LC. Protein kinase R as mediator of the effects of interferon (IFN) gamma and tumor necrosis factor (TNF) alpha on normal and dysplastic hematopoiesis. The Journal of Biological Chemistry. 286: 27506-14. PMID 21659535 DOI: 10.1074/Jbc.M111.238501  0.794
2011 Eklund EA, Platanias LC. Inhibition of histone deacetylase 6 as a therapeutic strategy for acute lymphocytic leukemia. Leukemia & Lymphoma. 52: 1421-2. PMID 21657957 DOI: 10.3109/10428194.2011.577259  0.3
2011 Zhou L, Opalinska J, Sohal D, Yu Y, Mo Y, Bhagat T, Abdel-Wahab O, Fazzari M, Figueroa M, Alencar C, Zhang J, Kambhampati S, Parmar S, Nischal S, Hueck C, ... ... Platanias LC, et al. Aberrant epigenetic and genetic marks are seen in myelodysplastic leukocytes and reveal Dock4 as a candidate pathogenic gene on chromosome 7q. The Journal of Biological Chemistry. 286: 25211-23. PMID 21532034 DOI: 10.1074/Jbc.M111.235028  0.325
2011 Altman JK, Sassano A, Kaur S, Glaser H, Kroczynska B, Redig AJ, Russo S, Barr S, Platanias LC. Dual mTORC2/mTORC1 targeting results in potent suppressive effects on acute myeloid leukemia (AML) progenitors. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 4378-88. PMID 21415215 DOI: 10.1158/1078-0432.Ccr-10-2285  0.701
2011 Redig AJ, Vakana E, Platanias LC. Regulation of mammalian target of rapamycin and mitogen activated protein kinase pathways by BCR-ABL. Leukemia & Lymphoma. 52: 45-53. PMID 21299459 DOI: 10.3109/10428194.2010.546919  0.839
2011 Hussain AR, Ahmed M, Ahmed S, Manogaran P, Platanias LC, Alvi SN, Al-Kuraya KS, Uddin S. Thymoquinone suppresses growth and induces apoptosis via generation of reactive oxygen species in primary effusion lymphoma. Free Radical Biology & Medicine. 50: 978-87. PMID 21215312 DOI: 10.1016/J.Freeradbiomed.2010.12.034  0.374
2011 Platanias LC. Mechanisms of BCR-ABL leukemogenesis and novel targets for the treatment of chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia. Leukemia & Lymphoma. 52: 2-3. PMID 21208039 DOI: 10.3109/10428194.2010.546922  0.318
2011 Zhou L, McMahon C, Bhagat T, Alencar C, Yu Y, Fazzari M, Sohal D, Heuck C, Gundabolu K, Ng C, Mo Y, Shen W, Wickrema A, Kong G, Friedman E, ... ... Platanias LC, et al. Reduced SMAD7 leads to overactivation of TGF-beta signaling in MDS that can be reversed by a specific inhibitor of TGF-beta receptor I kinase. Cancer Research. 71: 955-63. PMID 21189329 DOI: 10.1158/0008-5472.Can-10-2933  0.36
2011 Joshi S, Sharma B, Kaur S, Majchrzak B, Ueda T, Fukunaga R, Verma AK, Fish EN, Platanias LC. Essential role for Mnk kinases in type II interferon (IFNgamma) signaling and its suppressive effects on normal hematopoiesis. The Journal of Biological Chemistry. 286: 6017-26. PMID 21149447 DOI: 10.1074/Jbc.M110.197921  0.846
2011 Shah CA, Wang H, Bei L, Platanias LC, Eklund EA. HoxA10 regulates transcription of the gene encoding transforming growth factor beta2 (TGFbeta2) in myeloid cells. The Journal of Biological Chemistry. 286: 3161-76. PMID 21087928 DOI: 10.1074/Jbc.M110.183251  0.411
2011 Kroczynska B, Joshi S, Eklund EA, Verma A, Kotenko SV, Fish EN, Platanias LC. Regulatory effects of ribosomal S6 kinase 1 (RSK1) in IFNλ signaling. The Journal of Biological Chemistry. 286: 1147-56. PMID 21075852 DOI: 10.1074/Jbc.M110.183566  0.797
2011 Schinke CD, Das BC, Goel S, Bhagat T, Nischal S, Minucci S, Kabalka G, Gallagher RE, Evans T, Platanias LC, Verma A. Design, Synthesis and Biological Evaluation of A Boron Containing Retinoid As a Novel Therapeutic Agent for Acute Promyelocytic Leukemia Blood. 118: 5008-5008. DOI: 10.1182/Blood.V118.21.5008.5008  0.35
2011 Hussain AR, Ahmed M, Ahmed SO, Bu R, Khan OS, Platanias L, Al-Kuraya KS, Uddin S. Abstract 4784: Targeting NF-kappaB pathway with Bay11-7085 leads to inhibition of cell viability and induces apoptosis in primary effusion lymphoma cells Cancer Research. 71: 4784-4784. DOI: 10.1158/1538-7445.Am2011-4784  0.455
2011 Ahmed M, Hussain AR, Ahmed SO, Bu R, Thangavel S, Platanias LC, Al-Kuraya KS, Uddin S. Abstract 4775: Role of FoxM1 survival pathway in primary effusion lymphoma cells Cancer Research. 71: 4775-4775. DOI: 10.1158/1538-7445.Am2011-4775  0.436
2011 Platanias LC, Lurie RH. CS11-3. Mechanisms Of mRNA Translation Of ISGs In Malignant Cells. Implications For The Antitumor Effects Of Ifns Cytokine. 56: 60. DOI: 10.1016/J.Cyto.2011.07.371  0.363
2011 Burke D, Burkel D, Sonenberg N, Platanias LC, Fish EN. CS08-2. Ifn regulation of metabolism contributes to an antiviral response Cytokine. 56: 54. DOI: 10.1016/J.Cyto.2011.07.347  0.32
2010 Katsoulidis E, Kaur S, Platanias LC. Deregulation of Interferon Signaling in Malignant Cells. Pharmaceuticals (Basel, Switzerland). 3: 406-418. PMID 27713259 DOI: 10.3390/Ph3020406  0.411
2010 Katsoulidis E, Mavrommatis E, Woodard J, Shields MA, Sassano A, Carayol N, Sawicki KT, Munshi HG, Platanias LC. Role of interferon {alpha} (IFN{alpha})-inducible Schlafen-5 in regulation of anchorage-independent growth and invasion of malignant melanoma cells. The Journal of Biological Chemistry. 285: 40333-41. PMID 20956525 DOI: 10.1074/Jbc.M110.151076  0.436
2010 Woodard J, Joshi S, Viollet B, Hay N, Platanias LC. AMPK as a therapeutic target in renal cell carcinoma. Cancer Biology & Therapy. 10: 1168-77. PMID 20948309 DOI: 10.4161/Cbt.10.11.13629  0.75
2010 Vakana E, Sassano A, Platanias LC. Induction of autophagy by dual mTORC1-mTORC2 inhibition in BCR-ABL-expressing leukemic cells. Autophagy. 6: 966-7. PMID 20699667 DOI: 10.1073/Pnas.1005114107  0.832
2010 Huang W, Zhou W, Saberwal G, Konieczna I, Horvath E, Katsoulidis E, Platanias LC, Eklund EA. Interferon consensus sequence binding protein (ICSBP) decreases beta-catenin activity in myeloid cells by repressing GAS2 transcription. Molecular and Cellular Biology. 30: 4575-94. PMID 20679491 DOI: 10.1128/Mcb.01595-09  0.39
2010 Altman JK, Glaser H, Sassano A, Joshi S, Ueda T, Watanabe-Fukunaga R, Fukunaga R, Tallman MS, Platanias LC. Negative regulatory effects of Mnk kinases in the generation of chemotherapy-induced antileukemic responses. Molecular Pharmacology. 78: 778-84. PMID 20664001 DOI: 10.1124/Mol.110.064642  0.821
2010 Goussetis DJ, Altman JK, Glaser H, McNeer JL, Tallman MS, Platanias LC. Autophagy is a critical mechanism for the induction of the antileukemic effects of arsenic trioxide. The Journal of Biological Chemistry. 285: 29989-97. PMID 20656687 DOI: 10.1074/Jbc.M109.090530  0.436
2010 Goussetis DJ, Platanias LC. Arsenic trioxide and the phosphoinositide 3-kinase/akt pathway in chronic lymphocytic leukemia. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 16: 4311-2. PMID 20622048 DOI: 10.1158/1078-0432.Ccr-10-1496  0.487
2010 Carayol N, Vakana E, Sassano A, Kaur S, Goussetis DJ, Glaser H, Druker BJ, Donato NJ, Altman JK, Barr S, Platanias LC. Critical roles for mTORC2- and rapamycin-insensitive mTORC1-complexes in growth and survival of BCR-ABL-expressing leukemic cells. Proceedings of the National Academy of Sciences of the United States of America. 107: 12469-74. PMID 20616057 DOI: 10.1073/pnas.1005114107  0.822
2010 Woodard J, Platanias LC. AMP-activated kinase (AMPK)-generated signals in malignant melanoma cell growth and survival. Biochemical and Biophysical Research Communications. 398: 135-9. PMID 20599746 DOI: 10.1016/J.Bbrc.2010.06.052  0.495
2010 Singh AT, Evens AM, Anderson RJ, Beckstead JA, Sankar N, Sassano A, Bhalla S, Yang S, Platanias LC, Forte TM, Ryan RO, Gordon LI. All trans retinoic acid nanodisks enhance retinoic acid receptor mediated apoptosis and cell cycle arrest in mantle cell lymphoma. British Journal of Haematology. 150: 158-69. PMID 20507312 DOI: 10.1111/J.1365-2141.2010.08209.X  0.414
2010 Joshi S, Kaur S, Kroczynska B, Platanias LC. Mechanisms of mRNA translation of interferon stimulated genes. Cytokine. 52: 123-7. PMID 20409730 DOI: 10.1016/J.Cyto.2010.03.019  0.794
2010 Bhalla S, Gordon LI, David K, Prachand S, Singh AT, Yang S, Winter JN, Guo D, O'Halloran T, Platanias LC, Evens AM. Glutathione depletion enhances arsenic trioxide-induced apoptosis in lymphoma cells through mitochondrial-independent mechanisms. British Journal of Haematology. 150: 365-9. PMID 20408844 DOI: 10.1111/J.1365-2141.2010.08197.X  0.312
2010 McNeer JL, Goussetis DJ, Sassano A, Dolniak B, Kroczynska B, Glaser H, Altman JK, Platanias LC. Arsenic trioxide-dependent activation of thousand-and-one amino acid kinase 2 and transforming growth factor-beta-activated kinase 1. Molecular Pharmacology. 77: 828-35. PMID 20159944 DOI: 10.1124/Mol.109.061507  0.522
2010 Hussain AR, Khan AS, Ahmed SO, Ahmed M, Platanias LC, Al-Kuraya KS, Uddin S. Apigenin induces apoptosis via downregulation of S-phase kinase-associated protein 2-mediated induction of p27Kip1 in primary effusion lymphoma cells. Cell Proliferation. 43: 170-83. PMID 20074295 DOI: 10.1111/J.1365-2184.2009.00662.X  0.475
2010 Yang S, Evens AM, Prachand S, Singh ATK, Bhalla S, Platanias L, Gordon LI. Abstract 717: The diterpenoid lactone andrographolide (andro) induces apoptosis in all- trans-retinoic-acid (ATRA) resistant acute promyelocytic leukemia (APL) cell lines: Potential therapeutic implications Cancer Research. 70: 717-717. DOI: 10.1158/1538-7445.Am10-717  0.443
2010 Sharma B, Verma A, Platanias LC. PS3-16 Protein kinase R (PKR) in the regulation of normal hematopoiesis and in myelodysplastic syndromes Cytokine. 52: 85. DOI: 10.1016/J.Cyto.2010.07.355  0.737
2010 Vakana E, Platanias LC. PS3-15 Anti-leukemic effects of the AMPK activators AICAR and metformin in BCR-ABL expressing cells Cytokine. 52: 85. DOI: 10.1016/J.Cyto.2010.07.354  0.785
2010 Burke D, Sonenberg N, Platanias LC, Fish EN. PS2-77 IFN-mediated regulation of protein translation and its role in an antiviral immune response Cytokine. 52: 66. DOI: 10.1016/J.Cyto.2010.07.282  0.38
2010 Joshi SS, Kaur S, Fish EN, Platanias LC. PS1-63 Interferon (IFN) γ -mediated engagement of Mnk1 and its role in regulating mRNA translation and induction of antiproliferative responses Cytokine. 52: 30. DOI: 10.1016/J.Cyto.2010.07.135  0.747
2010 Kaur S, Joshi S, Sassano A, Hay N, Fish EN, Platanias LC. SS2-2 Roles of mTOR complexes in IFN-signaling and IFN-dependent biological responses Cytokine. 52: 13. DOI: 10.1016/J.Cyto.2010.07.057  0.747
2009 Kroczynska B, Kaur S, Platanias LC. Growth suppressive cytokines and the AKT/mTOR pathway. Cytokine. 48: 138-43. PMID 19682919 DOI: 10.1016/J.Cyto.2009.07.009  0.497
2009 Dumka D, Puri P, Carayol N, Lumby C, Balachandran H, Schuster K, Verma AK, Terada LS, Platanias LC, Parmar S. Activation of the p38 Map kinase pathway is essential for the antileukemic effects of dasatinib. Leukemia & Lymphoma. 50: 2017-29. PMID 19672773 DOI: 10.3109/10428190903147637  0.542
2009 Katsoulidis E, Carayol N, Woodard J, Konieczna I, Majchrzak-Kita B, Jordan A, Sassano A, Eklund EA, Fish EN, Platanias LC. Role of Schlafen 2 (SLFN2) in the generation of interferon alpha-induced growth inhibitory responses. The Journal of Biological Chemistry. 284: 25051-64. PMID 19592487 DOI: 10.1074/Jbc.M109.030445  0.51
2009 Joshi S, Kaur S, Redig AJ, Goldsborough K, David K, Ueda T, Watanabe-Fukunaga R, Baker DP, Fish EN, Fukunaga R, Platanias LC. Type I interferon (IFN)-dependent activation of Mnk1 and its role in the generation of growth inhibitory responses. Proceedings of the National Academy of Sciences of the United States of America. 106: 12097-102. PMID 19574459 DOI: 10.1073/Pnas.0900562106  0.852
2009 Hussain AR, Ahmed M, Ahmed SO, Al-Thari S, Khan AS, Razack S, Platanias LC, Al-Kuraya KS, Uddin S. Proteasome inhibitor MG-132 mediated expression of p27Kip1 via S-phase kinase protein 2 degradation induces cell cycle coupled apoptosis in primary effusion lymphoma cells. Leukemia & Lymphoma. 50: 1204-13. PMID 19557642 DOI: 10.1080/10428190902951799  0.405
2009 Altman JK, Platanias LC. Prospects for mTOR targeting in adult T cell leukemia. Leukemia & Lymphoma. 50: 525-6. PMID 19373648 DOI: 10.1080/10428190902741505  0.308
2009 Platanias LC. Biological responses to arsenic compounds. The Journal of Biological Chemistry. 284: 18583-7. PMID 19363033 DOI: 10.1074/Jbc.R900003200  0.379
2009 Kroczynska B, Kaur S, Katsoulidis E, Majchrzak-Kita B, Sassano A, Kozma SC, Fish EN, Platanias LC. Interferon-dependent engagement of eukaryotic initiation factor 4B via S6 kinase (S6K)- and ribosomal protein S6K-mediated signals. Molecular and Cellular Biology. 29: 2865-75. PMID 19289497 DOI: 10.1128/Mcb.01537-08  0.521
2009 Sassano A, Lo Iacono M, Antico G, Jordan A, Uddin S, Calogero RA, Platanias LC. Regulation of leukemic cell differentiation and retinoid-induced gene expression by statins. Molecular Cancer Therapeutics. 8: 615-25. PMID 19240159 DOI: 10.1158/1535-7163.Mct-08-1196  0.492
2009 Redig AJ, Sassano A, Majchrzak-Kita B, Katsoulidis E, Liu H, Altman JK, Fish EN, Wickrema A, Platanias LC. Activation of protein kinase C{eta} by type I interferons. The Journal of Biological Chemistry. 284: 10301-14. PMID 19211565 DOI: 10.1074/Jbc.M807254200  0.751
2009 Minhajuddin M, Bijli KM, Fazal F, Sassano A, Nakayama KI, Hay N, Platanias LC, Rahman A. Protein kinase C-delta and phosphatidylinositol 3-kinase/Akt activate mammalian target of rapamycin to modulate NF-kappaB activation and intercellular adhesion molecule-1 (ICAM-1) expression in endothelial cells. The Journal of Biological Chemistry. 284: 4052-61. PMID 19074768 DOI: 10.1074/Jbc.M805032200  0.525
2009 Bhalla S, Gordon LI, Singh A, Prachand S, Yang S, Winter JN, Guo D, O'Halloran T, Platanias LC, Evens AM. Glutathione Depletion Enhances Arsenic Trioxide-Induced Apoptosis in Lymphoma Cells through Mitochondrial and Caspase-Independent Mechanisms. Blood. 114: 2708-2708. DOI: 10.1182/Blood.V114.22.2708.2708  0.376
2009 Platanias LC, Lurie RH. Signaling pathways controlling mRNA translation of interferon regulated genes Cytokine. 48: 30. DOI: 10.1016/J.Cyto.2009.07.111  0.381
2008 Kaur S, Sassano A, Joseph AM, Majchrzak-Kita B, Eklund EA, Verma A, Brachmann SM, Fish EN, Platanias LC. Dual regulatory roles of phosphatidylinositol 3-kinase in IFN signaling. Journal of Immunology (Baltimore, Md. : 1950). 181: 7316-23. PMID 18981154 DOI: 10.4049/Jimmunol.181.10.7316  0.493
2008 Navas T, Zhou L, Estes M, Haghnazari E, Nguyen AN, Mo Y, Pahanish P, Mohindru M, Cao T, Higgins LS, Platanias LC, List A, Verma A, Bhagat T, Gajavelli S, et al. Inhibition of p38alpha MAPK disrupts the pathological loop of proinflammatory factor production in the myelodysplastic syndrome bone marrow microenvironment. Leukemia & Lymphoma. 49: 1963-75. PMID 18949619 DOI: 10.1080/10428190802322919  0.37
2008 Hussain AR, Ahmed M, Al-Jomah NA, Khan AS, Manogaran P, Sultana M, Abubaker J, Platanias LC, Al-Kuraya KS, Uddin S. Curcumin suppresses constitutive activation of nuclear factor-kappa B and requires functional Bax to induce apoptosis in Burkitt's lymphoma cell lines. Molecular Cancer Therapeutics. 7: 3318-29. PMID 18852135 DOI: 10.1158/1535-7163.Mct-08-0541  0.38
2008 Kaur S, Katsoulidis E, Platanias LC. Akt and mRNA translation by interferons. Cell Cycle (Georgetown, Tex.). 7: 2112-6. PMID 18635959 DOI: 10.4161/Cc.7.14.6258  0.484
2008 Woodard J, Sassano A, Hay N, Platanias LC. Statin-dependent suppression of the Akt/mammalian target of rapamycin signaling cascade and programmed cell death 4 up-regulation in renal cell carcinoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 14: 4640-9. PMID 18628479 DOI: 10.1158/1078-0432.Ccr-07-5232  0.436
2008 Redig AJ, Platanias LC. Protein kinase C signalling in leukemia. Leukemia & Lymphoma. 49: 1255-62. PMID 18604714 DOI: 10.1080/10428190802007726  0.719
2008 Zhou L, Nguyen AN, Sohal D, Ying Ma J, Pahanish P, Gundabolu K, Hayman J, Chubak A, Mo Y, Bhagat TD, Das B, Kapoun AM, Navas TA, Parmar S, Kambhampati S, ... ... Platanias LC, et al. Inhibition of the TGF-beta receptor I kinase promotes hematopoiesis in MDS. Blood. 112: 3434-43. PMID 18474728 DOI: 10.1182/Blood-2008-02-139824  0.402
2008 Uddin S, Platanias LC. Sphingosine kinase is an attractive target for novel pharmacological interventions in non-Hodgkin lymphomas. Leukemia & Lymphoma. 49: 850-1. PMID 18464106 DOI: 10.1080/10428190802087496  0.362
2008 Kaur S, Sassano A, Dolniak B, Joshi S, Majchrzak-Kita B, Baker DP, Hay N, Fish EN, Platanias LC. Role of the Akt pathway in mRNA translation of interferon-stimulated genes. Proceedings of the National Academy of Sciences of the United States of America. 105: 4808-13. PMID 18339807 DOI: 10.1073/Pnas.0710907105  0.808
2008 Murooka TT, Rahbar R, Platanias LC, Fish EN. CCL5-mediated T-cell chemotaxis involves the initiation of mRNA translation through mTOR/4E-BPl Blood. 111: 4892-4901. PMID 18337562 DOI: 10.1182/Blood-2007-11-125039  0.426
2008 Altman JK, Platanias LC. Exploiting the mammalian target of rapamycin pathway in hematologic malignancies. Current Opinion in Hematology. 15: 88-94. PMID 18300753 DOI: 10.1097/Moh.0B013E3282F3Deaa  0.384
2008 Dolniak B, Katsoulidis E, Carayol N, Altman JK, Redig AJ, Tallman MS, Ueda T, Watanabe-Fukunaga R, Fukunaga R, Platanias LC. Regulation of arsenic trioxide-induced cellular responses by Mnk1 and Mnk2. The Journal of Biological Chemistry. 283: 12034-42. PMID 18299328 DOI: 10.1074/Jbc.M708816200  0.789
2008 Katsoulidis E, Sassano A, Majchrzak-Kita B, Carayol N, Yoon P, Jordan A, Druker BJ, Fish EN, Platanias LC. Suppression of interferon (IFN)-inducible genes and IFN-mediated functional responses in BCR-ABL-expressing cells. The Journal of Biological Chemistry. 283: 10793-803. PMID 18287094 DOI: 10.1074/Jbc.M706816200  0.804
2008 Kannan-Thulasiraman P, Dolniak B, Kaur S, Sassano A, Kalvakolanu DV, Hay N, Platanias LC. Role of the translational repressor 4E-BP1 in the regulation of p21(Waf1/Cip1) expression by retinoids. Biochemical and Biophysical Research Communications. 368: 983-9. PMID 18280804 DOI: 10.1016/J.Bbrc.2008.02.028  0.441
2008 Konieczna I, Horvath E, Wang H, Lindsey S, Saberwal G, Bei L, Huang W, Platanias L, Eklund EA. Constitutive activation of SHP2 in mice cooperates with ICSBP deficiency to accelerate progression to acute myeloid leukemia. The Journal of Clinical Investigation. 118: 853-67. PMID 18246201 DOI: 10.1172/Jci33742  0.435
2008 Carayol N, Katsoulidis E, Sassano A, Altman JK, Druker BJ, Platanias LC. Suppression of programmed cell death 4 (PDCD4) protein expression by BCR-ABL-regulated engagement of the mTOR/p70 S6 kinase pathway. The Journal of Biological Chemistry. 283: 8601-10. PMID 18223253 DOI: 10.1074/Jbc.M707934200  0.561
2008 Sassano A, Platanias LC. Statins in tumor suppression. Cancer Letters. 260: 11-9. PMID 18180097 DOI: 10.1016/J.Canlet.2007.11.036  0.386
2008 Altman JK, Yoon P, Katsoulidis E, Kroczynska B, Sassano A, Redig AJ, Glaser H, Jordan A, Tallman MS, Hay N, Platanias LC. Regulatory effects of mammalian target of rapamycin-mediated signals in the generation of arsenic trioxide responses. The Journal of Biological Chemistry. 283: 1992-2001. PMID 18048359 DOI: 10.1074/Jbc.M705227200  0.841
2008 McNeer JL, Dolniak B, Kroczynska B, Sassano A, Platanias L. Activation of TAO2 Kinase by Arsenic Trioxide in Leukemic Cells Blood. 112: 5324-5324. DOI: 10.1182/Blood.V112.11.5324.5324  0.552
2008 Altman JK, Glaser H, Redig A, Sassano A, Tallman MS, Platanias LC. Targeting the Mnk Pathway Enhances Chemotherapy-Induced Antileukemic Responses. Blood. 112: 1617-1617. DOI: 10.1182/Blood.V112.11.1617.1617  0.776
2008 Burke D, Sonenberg N, Platanias LC, Fish EN. 193 IFN-mediated inactivation of the 4E-BP1 repressor of mRNA translation influences an antiviral response Cytokine. 43: 285. DOI: 10.1016/J.Cyto.2008.07.255  0.327
2008 Kaur S, Sassano A, Joseph AM, Majchrzak-Kita B, Eklund EA, Fish EN, Verma A, Brachmann SM, Platanias LC. 1 Dual regulatory roles of the phosphatidylinositol 3-kinase in interferon signaling Cytokine. 43: 237. DOI: 10.1016/J.Cyto.2008.07.041  0.477
2007 Redig AJ, Platanias LC. The protein kinase C (PKC) family of proteins in cytokine signaling in hematopoiesis. Journal of Interferon & Cytokine Research : the Official Journal of the International Society For Interferon and Cytokine Research. 27: 623-36. PMID 17784814 DOI: 10.1089/Jir.2007.0007  0.743
2007 Sassano A, Katsoulidis E, Antico G, Altman JK, Redig AJ, Minucci S, Tallman MS, Platanias LC. Suppressive effects of statins on acute promyelocytic leukemia cells. Cancer Research. 67: 4524-32. PMID 17483369 DOI: 10.1158/0008-5472.Can-06-3686  0.747
2007 Hussain AR, Al-Jomah NA, Siraj AK, Manogaran P, Al-Hussein K, Abubaker J, Platanias LC, Al-Kuraya KS, Uddin S. Sanguinarine-dependent induction of apoptosis in primary effusion lymphoma cells. Cancer Research. 67: 3888-97. PMID 17440103 DOI: 10.1158/0008-5472.Can-06-3764  0.398
2007 Ma X, Kalakonda S, Srinivasula SM, Reddy SP, Platanias LC, Kalvakolanu DV. GRIM-19 associates with the serine protease HtrA2 for promoting cell death Oncogene. 26: 4842-4849. PMID 17297443 DOI: 10.1038/Sj.Onc.1210287  0.4
2007 Kaur S, Lal L, Sassano A, Majchrzak-Kita B, Srikanth M, Baker DP, Petroulakis E, Hay N, Sonenberg N, Fish EN, Platanias LC. Regulatory effects of mammalian target of rapamycin-activated pathways in type I and II interferon signaling. The Journal of Biological Chemistry. 282: 1757-68. PMID 17114181 DOI: 10.1074/Jbc.M607365200  0.463
2007 Bijli KM, Minhajuddin M, Fazal F, O'Reilly MA, Platanias LC, Rahman A. c-Src interacts with and phosphorylates RelA/p65 to promote thrombin-induced ICAM-1 expression in endothelial cells. American Journal of Physiology-Lung Cellular and Molecular Physiology. 292. PMID 17012367 DOI: 10.1152/Ajplung.00163.2006  0.362
2007 Bhalla S, Singh AT, Prachand S, Haque Q, O’Halloran TV, Winter JN, Schumacker PT, Platanias LC, Gordon LI, Evens AM. Arsenic Trioxide (As2O3) Mediated Cell Death in Hodgkin Lymphoma (HL) and Non-Hodgkin Lymphoma (NHL): Investigation of Reactive Oxygen Species (ROS), Caspase, and MAP Kinase Signaling Pathways. Blood. 110: 2576-2576. DOI: 10.1182/Blood.V110.11.2576.2576  0.423
2007 Konieczna I, Horvath E, Wang H, Platanias L, Eklund E. ICSBP Haplo-Insufficiency Synergizes with SHP2-Activation for Apoptosis Resistance and Cytokine Hypersensitivity in Myeloid Progenitors. Blood. 110: 2209-2209. DOI: 10.1182/Blood.V110.11.2209.2209  0.493
2006 Yoon P, Giafis N, Smith J, Mears H, Katsoulidis E, Sassano A, Altman J, Redig AJ, Tallman MS, Platanias LC. Activation of mammalian target of rapamycin and the p70 S6 kinase by arsenic trioxide in BCR-ABL-expressing cells. Molecular Cancer Therapeutics. 5: 2815-23. PMID 17121928 DOI: 10.1158/1535-7163.Mct-06-0263  0.824
2006 Navas TA, Mohindru M, Estes M, Ma JY, Sokol L, Pahanish P, Parmar S, Haghnazari E, Zhou L, Collins R, Kerr I, Nguyen AN, Xu Y, Platanias LC, List AA, et al. Inhibition of overactivated p38 MAPK can restore hematopoiesis in myelodysplastic syndrome progenitors. Blood. 108: 4170-7. PMID 16940419 DOI: 10.1182/Blood-2006-05-023093  0.439
2006 Giafis N, Katsoulidis E, Sassano A, Tallman MS, Higgins LS, Nebreda AR, Davis RJ, Platanias LC. Role of the p38 mitogen-activated protein kinase pathway in the generation of arsenic trioxide-dependent cellular responses. Cancer Research. 66: 6763-71. PMID 16818652 DOI: 10.1158/0008-5472.Can-05-3699  0.837
2006 Rahbar R, Murooka TT, Hinek AA, Galligan CL, Sassano A, Yu C, Srivastava K, Platanias LC, Fish EN. Vaccinia virus activation of CCR5 invokes tyrosine phosphorylation signaling events that support virus replication. Journal of Virology. 80: 7245-59. PMID 16809330 DOI: 10.1128/Jvi.00463-06  0.355
2006 Kannan-Thulasiraman P, Katsoulidis E, Tallman MS, Arthur JS, Platanias LC. Activation of the mitogen- and stress-activated kinase 1 by arsenic trioxide. The Journal of Biological Chemistry. 281: 22446-52. PMID 16762916 DOI: 10.1074/Jbc.M603111200  0.54
2006 Hussain AR, Al-Rasheed M, Manogaran PS, Al-Hussein KA, Platanias LC, Al Kuraya K, Uddin S. Curcumin induces apoptosis via inhibition of PI3'-kinase/AKT pathway in acute T cell leukemias. Apoptosis : An International Journal On Programmed Cell Death. 11: 245-54. PMID 16502262 DOI: 10.1007/S10495-006-3392-3  0.483
2006 Platanias LC. Introduction: interferon signals: what is classical and what is nonclassical? Journal of Interferon & Cytokine Research : the Official Journal of the International Society For Interferon and Cytokine Research. 25: 732. PMID 16375600 DOI: 10.1089/Jir.2005.25.732  0.324
2006 Aranha O, Kaur S, Smith J, Sassano A, Platanias LC. Regulation of pathways downstream of mTOR by imatinib mesylate in CML cells Journal of Clinical Oncology. 24: 6595-6595. DOI: 10.1200/Jco.2006.24.18_Suppl.6595  0.546
2006 Altman JK, Yoon PJ, Sassano A, Smith J, Mears H, Tallman MS, Platanias LC. The combination of arsenic trioxide and rapamycin has potent inhibitory effects on acute myeloid leukemia (AML) cells Journal of Clinical Oncology. 24: 13101-13101. DOI: 10.1200/Jco.2006.24.18_Suppl.13101  0.503
2006 Altman JK, Sassano A, Yoon PJ, Redig AJ, Katsoulidis E, Tallman MS, Platanias LC. Targeting the mTOR Pathway Suppresses the Growth of Acute Myeloid Leukemia (AML) Progenitors and Enhances Arsenic Trioxide Induced Antileukemic Responses. Blood. 108: 1898-1898. DOI: 10.1182/Blood.V108.11.1898.1898  0.849
2006 Platanias LC. Interferon-inducible genes and aplastic anemia Blood. 107: 2-3. DOI: 10.1182/Blood-2005-10-4053  0.311
2005 Kaur S, Uddin S, Platanias LC. The PI3' kinase pathway in interferon signaling. Journal of Interferon & Cytokine Research : the Official Journal of the International Society For Interferon and Cytokine Research. 25: 780-7. PMID 16375606 DOI: 10.1089/Jir.2005.25.780  0.508
2005 Katsoulidis E, Li Y, Mears H, Platanias LC. The p38 mitogen-activated protein kinase pathway in interferon signal transduction. Journal of Interferon & Cytokine Research : the Official Journal of the International Society For Interferon and Cytokine Research. 25: 749-56. PMID 16375603 DOI: 10.1089/Jir.2005.25.749  0.52
2005 Katsoulidis E, Li Y, Yoon P, Sassano A, Altman J, Kannan-Thulasiraman P, Balasubramanian L, Parmar S, Varga J, Tallman MS, Verma A, Platanias LC. Role of the p38 mitogen-activated protein kinase pathway in cytokine-mediated hematopoietic suppression in myelodysplastic syndromes. Cancer Research. 65: 9029-37. PMID 16204077 DOI: 10.1158/0008-5472.Can-04-4555  0.795
2005 Uddin S, Hussain AR, Manogaran PS, Al-Hussein K, Platanias LC, Gutierrez MI, Bhatia KG. Curcumin suppresses growth and induces apoptosis in primary effusion lymphoma. Oncogene. 24: 7022-30. PMID 16044161 DOI: 10.1038/Sj.Onc.1208864  0.471
2005 Sassano A, Verma A, Platanias LC. Mitogen-activated protein kinase pathways in interferon signaling. Methods in Molecular Medicine. 116: 135-50. PMID 16000859 DOI: 10.1385/1-59259-939-7:135  0.527
2005 Emerling BM, Platanias LC, Black E, Nebreda AR, Davis RJ, Chandel NS. Mitochondrial reactive oxygen species activation of p38 mitogen-activated protein kinase is required for hypoxia signaling. Molecular and Cellular Biology. 25: 4853-62. PMID 15923604 DOI: 10.1128/Mcb.25.12.4853-4862.2005  0.436
2005 Roy SK, Shuman JD, Platanias LC, Shapiro PS, Reddy SP, Johnson PF, Kalvakolanu DV. A role for mixed lineage kinases in regulating transcription factor CCAAT/enhancer-binding protein-{beta}-dependent gene expression in response to interferon-{gamma}. The Journal of Biological Chemistry. 280: 24462-71. PMID 15878863 DOI: 10.1074/Jbc.M413661200  0.466
2005 Platanias LC. Mechanisms of type-I- and type-II-interferon-mediated signalling. Nature Reviews. Immunology. 5: 375-86. PMID 15864272 DOI: 10.1038/Nri1604  0.515
2005 Kaur S, Parmar S, Smith J, Katsoulidis E, Li Y, Sassano A, Majchrzak B, Uddin S, Tallman MS, Fish EN, Platanias LC. Role of protein kinase C-delta (PKC-delta) in the generation of the effects of IFN-alpha in chronic myelogenous leukemia cells. Experimental Hematology. 33: 550-7. PMID 15850832 DOI: 10.1016/J.Exphem.2005.01.014  0.423
2005 Huang X, Chen S, Xu L, Liu Y, Deb DK, Platanias LC, Bergan RC. Genistein inhibits p38 map kinase activation, matrix metalloproteinase type 2, and cell invasion in human prostate epithelial cells. Cancer Research. 65: 3470-8. PMID 15833883 DOI: 10.1158/0008-5472.Can-04-2807  0.341
2005 Ghias K, Ma C, Gandhi V, Platanias LC, Krett NL, Rosen ST. 8-Amino-adenosine induces loss of phosphorylation of p38 mitogen-activated protein kinase, extracellular signal-regulated kinase 1/2, and Akt kinase: role in induction of apoptosis in multiple myeloma. Molecular Cancer Therapeutics. 4: 569-77. PMID 15827330 DOI: 10.1158/1535-7163.Mct-04-0303  0.52
2005 Parmar S, Smith J, Sassano A, Uddin S, Katsoulidis E, Majchrzak B, Kambhampati S, Eklund EA, Tallman MS, Fish EN, Platanias LC. Differential regulation of the p70 S6 kinase pathway by interferon alpha (IFNalpha) and imatinib mesylate (STI571) in chronic myelogenous leukemia cells. Blood. 106: 2436-43. PMID 15790787 DOI: 10.1182/Blood-2004-10-4003  0.577
2005 Li Y, Batra S, Sassano A, Majchrzak B, Levy DE, Gaestel M, Fish EN, Davis RJ, Platanias LC. Activation of mitogen-activated protein kinase kinase (MKK) 3 and MKK6 by type I interferons. The Journal of Biological Chemistry. 280: 10001-10. PMID 15644321 DOI: 10.1074/Jbc.M410972200  0.537
2005 Uddin S, Platanias LC. Mechanisms of type-I interferon signal transduction. Journal of Biochemistry and Molecular Biology. 37: 635-41. PMID 15607020 DOI: 10.5483/Bmbrep.2004.37.6.635  0.433
2005 Buonamici S, Li D, Mikhail FM, Sassano A, Platanias LC, Colamonici O, Anastasi J, Nucifora G. EVI1 abrogates interferon-alpha response by selectively blocking PML induction. The Journal of Biological Chemistry. 280: 428-36. PMID 15519999 DOI: 10.1074/Jbc.M410836200  0.469
2005 Lal L, Li Y, Smith J, Sassano A, Uddin S, Parmar S, Tallman MS, Minucci S, Hay N, Platanias LC. Activation of the p70 S6 kinase by all-trans-retinoic acid in acute promyelocytic leukemia cells. Blood. 105: 1669-77. PMID 15471950 DOI: 10.1182/Blood-2004-06-2078  0.473
2004 Mori Y, Ishida W, Bhattacharyya S, Li Y, Platanias LC, Varga J. Selective inhibition of activin receptor-like kinase 5 signaling blocks profibrotic transforming growth factor beta responses in skin fibroblasts. Arthritis and Rheumatism. 50: 4008-21. PMID 15593186 DOI: 10.1002/Art.20658  0.438
2004 Kambhampati S, Verma A, Li Y, Parmar S, Sassano A, Platanias LC. Signalling pathways activated by all-trans-retinoic acid in acute promyelocytic leukemia cells. Leukemia & Lymphoma. 45: 2175-85. PMID 15512805 DOI: 10.1080/10428190410001722053  0.477
2004 Zhu C, Saberwal G, Lu Y, Platanias LC, Eklund EA. The interferon consensus sequence-binding protein activates transcription of the gene encoding neurofibromin 1. The Journal of Biological Chemistry. 279: 50874-85. PMID 15371411 DOI: 10.1074/Jbc.M405736200  0.407
2004 Munshi HG, Wu YI, Mukhopadhyay S, Ottaviano AJ, Sassano A, Koblinski JE, Platanias LC, Stack MS. Differential regulation of membrane type 1-matrix metalloproteinase activity by ERK 1/2- and p38 MAPK-modulated tissue inhibitor of metalloproteinases 2 expression controls transforming growth factor-beta1-induced pericellular collagenolysis. The Journal of Biological Chemistry. 279: 39042-50. PMID 15247230 DOI: 10.1074/Jbc.M404958200  0.376
2004 Uddin S, Hussain A, Al-Hussein K, Platanias LC, Bhatia KG. Inhibition of phosphatidylinositol 3'-kinase induces preferentially killing of PTEN-null T leukemias through AKT pathway. Biochemical and Biophysical Research Communications. 320: 932-8. PMID 15240138 DOI: 10.1016/J.Bbrc.2004.06.038  0.468
2004 Mukhopadhyay S, Munshi HG, Kambhampati S, Sassano A, Platanias LC, Stack MS. Calcium-induced matrix metalloproteinase 9 gene expression is differentially regulated by ERK1/2 and p38 MAPK in oral keratinocytes and oral squamous cell carcinoma. The Journal of Biological Chemistry. 279: 33139-46. PMID 15180997 DOI: 10.1074/Jbc.M405194200  0.414
2004 Srivastava KK, Batra S, Sassano A, Li Y, Majchrzak B, Kiyokawa H, Altman A, Fish EN, Platanias LC. Engagement of protein kinase C-theta in interferon signaling in T-cells. The Journal of Biological Chemistry. 279: 29911-20. PMID 15150272 DOI: 10.1074/Jbc.M401997200  0.539
2004 Parmar S, Katsoulidis E, Verma A, Li Y, Sassano A, Lal L, Majchrzak B, Ravandi F, Tallman MS, Fish EN, Platanias LC. Role of the p38 mitogen-activated protein kinase pathway in the generation of the effects of imatinib mesylate (STI571) in BCR-ABL-expressing cells. The Journal of Biological Chemistry. 279: 25345-52. PMID 15056660 DOI: 10.1074/Jbc.M400590200  0.559
2004 Lekmine F, Sassano A, Uddin S, Smith J, Majchrzak B, Brachmann SM, Hay N, Fish EN, Platanias LC. Interferon-gamma engages the p70 S6 kinase to regulate phosphorylation of the 40S S6 ribosomal protein. Experimental Cell Research. 295: 173-82. PMID 15051500 DOI: 10.1016/J.Yexcr.2003.12.021  0.512
2004 Parmar S, Platanias LC. Interferons: mechanisms of action and clinical applications. Current Opinion in Oncology. 15: 431-9. PMID 14624225 DOI: 10.1097/00001622-200311000-00005  0.312
2004 Li Y, Sassano A, Majchrzak B, Deb DK, Levy DE, Gaestel M, Nebreda AR, Fish EN, Platanias LC. Role of p38alpha Map kinase in Type I interferon signaling. The Journal of Biological Chemistry. 279: 970-9. PMID 14578350 DOI: 10.1074/Jbc.M309927200  0.538
2004 Mohindru M, Pahanish P, Katsoulidis E, Collins R, Rogers T, Navas T, Higgins L, Platanias L, Verma A. Novel P38 MAP Kinase Inhibitor and Anti-P38 RNA Interference as Potential Therapeutic Approaches in Myelodysplastic Syndromes. Blood. 104: 470-470. DOI: 10.1182/Blood.V104.11.470.470  0.459
2004 Platanias LC. SMRT interactions, repression, and Flt3-ITD Blood. 103: 4382-4382. DOI: 10.1182/Blood-2004-04-1380  0.404
2003 Deonarain R, Verma A, Porter AC, Gewert DR, Platanias LC, Fish EN. Critical roles for IFN-beta in lymphoid development, myelopoiesis, and tumor development: links to tumor necrosis factor alpha. Proceedings of the National Academy of Sciences of the United States of America. 100: 13453-8. PMID 14597717 DOI: 10.1073/Pnas.2230460100  0.31
2003 Uddin S, Lekmine F, Sassano A, Rui H, Fish EN, Platanias LC. Role of Stat5 in type I interferon-signaling and transcriptional regulation. Biochemical and Biophysical Research Communications. 308: 325-30. PMID 12901872 DOI: 10.1016/S0006-291X(03)01382-2  0.529
2003 Hayes SA, Huang X, Kambhampati S, Platanias LC, Bergan RC. p38 MAP kinase modulates Smad-dependent changes in human prostate cell adhesion. Oncogene. 22: 4841-50. PMID 12894225 DOI: 10.1038/Sj.Onc.1206730  0.453
2003 Verma A, Kambhampati S, Parmar S, Platanias LC. Jak family of kinases in cancer. Cancer Metastasis Reviews. 22: 423-34. PMID 12884916 DOI: 10.1023/A:1023805715476  0.506
2003 Deb DK, Sassano A, Lekmine F, Majchrzak B, Verma A, Kambhampati S, Uddin S, Rahman A, Fish EN, Platanias LC. Activation of protein kinase C delta by IFN-gamma. Journal of Immunology (Baltimore, Md. : 1950). 171: 267-73. PMID 12817007 DOI: 10.4049/Jimmunol.171.1.267  0.495
2003 Kambhampati S, Li Y, Verma A, Sassano A, Majchrzak B, Deb DK, Parmar S, Giafis N, Kalvakolanu DV, Rahman A, Uddin S, Minucci S, Tallman MS, Fish EN, Platanias LC. Activation of protein kinase C delta by all-trans-retinoic acid. The Journal of Biological Chemistry. 278: 32544-51. PMID 12805378 DOI: 10.1074/Jbc.M301523200  0.809
2003 Lekmine F, Uddin S, Sassano A, Parmar S, Brachmann SM, Majchrzak B, Sonenberg N, Hay N, Fish EN, Platanias LC. Activation of the p70 S6 kinase and phosphorylation of the 4E-BP1 repressor of mRNA translation by type I interferons. The Journal of Biological Chemistry. 278: 27772-80. PMID 12759354 DOI: 10.1074/Jbc.M301364200  0.53
2003 Platanias LC. The p38 mitogen-activated protein kinase pathway and its role in interferon signaling. Pharmacology & Therapeutics. 98: 129-42. PMID 12725866 DOI: 10.1016/S0163-7258(03)00016-0  0.555
2003 Platanias LC. Map kinase signaling pathways and hematologic malignancies. Blood. 101: 4667-79. PMID 12623839 DOI: 10.1182/Blood-2002-12-3647  0.486
2002 Deonarain R, Chan DCM, Platanias LC, Fish EN. Interferon-α / β-Receptor Interactions: A Complex Story Unfolding Current Pharmaceutical Design. 8: 2131-2137. PMID 12369858 DOI: 10.2174/1381612023393288  0.329
2002 Verma A, Mohindru M, Deb DK, Sassano A, Kambhampati S, Ravandi F, Minucci S, Kalvakolanu DV, Platanias LC. Activation of Rac1 and the p38 mitogen-activated protein kinase pathway in response to arsenic trioxide. The Journal of Biological Chemistry. 277: 44988-95. PMID 12239215 DOI: 10.1074/Jbc.M207176200  0.54
2002 Verma A, Platanias LC. Signaling via the interferon-alpha receptor in chronic myelogenous leukemia cells. Leukemia & Lymphoma. 43: 703-9. PMID 12153154 DOI: 10.1080/10428190290016782  0.53
2002 Verma A, Deb DK, Sassano A, Kambhampati S, Wickrema A, Uddin S, Mohindru M, Van Besien K, Platanias LC. Cutting edge: activation of the p38 mitogen-activated protein kinase signaling pathway mediates cytokine-induced hemopoietic suppression in aplastic anemia. Journal of Immunology (Baltimore, Md. : 1950). 168: 5984-8. PMID 12055203 DOI: 10.4049/Jimmunol.168.12.5984  0.465
2002 Roy SK, Hu J, Meng Q, Xia Y, Shapiro PS, Reddy SP, Platanias LC, Lindner DJ, Johnson PF, Pritchard C, Pagés G, Pouyssegur J, Kalvakolanu DV. MEKK1 plays a critical role in activating the transcription factor C/EBP-beta-dependent gene expression in response to IFN-gamma. Proceedings of the National Academy of Sciences of the United States of America. 99: 7945-50. PMID 12048245 DOI: 10.1073/Pnas.122075799  0.491
2002 Mahmud DL, G-Amlak M, Deb DK, Platanias LC, Uddin S, Wickrema A. Phosphorylation of forkhead transcription factors by erythropoietin and stem cell factor prevents acetylation and their interaction with coactivator p300 in erythroid progenitor cells. Oncogene. 21: 1556-62. PMID 11896584 DOI: 10.1038/Sj.Onc.1205230  0.448
2002 Lekmine F, Sassano A, Uddin S, Majchrzak B, Miura O, Druker BJ, Fish EN, Imamoto A, Platanias LC. The CrkL adapter protein is required for type I interferon-dependent gene transcription and activation of the small G-protein Rap1. Biochemical and Biophysical Research Communications. 291: 744-50. PMID 11866427 DOI: 10.1006/Bbrc.2002.6516  0.5
2002 Uddin S, Sassano A, Deb DK, Verma A, Majchrzak B, Rahman A, Malik AB, Fish EN, Platanias LC. Protein kinase C-delta (PKC-delta ) is activated by type I interferons and mediates phosphorylation of Stat1 on serine 727. The Journal of Biological Chemistry. 277: 14408-16. PMID 11839738 DOI: 10.1074/Jbc.M109671200  0.524
2002 Verma A, Deb DK, Sassano A, Uddin S, Varga J, Wickrema A, Platanias LC. Activation of the p38 mitogen-activated protein kinase mediates the suppressive effects of type I interferons and transforming growth factor-beta on normal hematopoiesis. The Journal of Biological Chemistry. 277: 7726-35. PMID 11773065 DOI: 10.1074/Jbc.M106640200  0.519
2001 Masters J, Hinek AA, Uddin S, Platanias LC, Zeng W, McFadden G, Fish EN. Poxvirus infection rapidly activates tyrosine kinase signal transduction. The Journal of Biological Chemistry. 276: 48371-5. PMID 11591716 DOI: 10.1074/Jbc.M108019200  0.379
2001 Rahman A, Anwar KN, Uddin S, Xu N, Ye RD, Platanias LC, Malik AB. Protein kinase C-delta regulates thrombin-induced ICAM-1 gene expression in endothelial cells via activation of p38 mitogen-activated protein kinase. Molecular and Cellular Biology. 21: 5554-65. PMID 11463837 DOI: 10.1128/Mcb.21.16.5554-5565.2001  0.496
2001 Mayer IA, Verma A, Grumbach IM, Uddin S, Lekmine F, Ravandi F, Majchrzak B, Fujita S, Fish EN, Platanias LC. The p38 MAPK pathway mediates the growth inhibitory effects of interferon-alpha in BCR-ABL-expressing cells. The Journal of Biological Chemistry. 276: 28570-7. PMID 11353767 DOI: 10.1074/Jbc.M011685200  0.409
2001 Wong M, Uddin S, Majchrzak B, Huynh T, Proudfoot AE, Platanias LC, Fish EN. Rantes activates Jak2 and Jak3 to regulate engagement of multiple signaling pathways in T cells. The Journal of Biological Chemistry. 276: 11427-31. PMID 11278738 DOI: 10.1074/Jbc.M010750200  0.524
2001 Grumbach IM, Mayer IA, Uddin S, Lekmine F, Majchrzak B, Yamauchi H, Fujita S, Druker B, Fish EN, Platanias LC. Engagement of the CrkL adaptor in interferon alpha signalling in BCR-ABL-expressing cells. British Journal of Haematology. 112: 327-36. PMID 11167825 DOI: 10.1046/J.1365-2141.2001.02556.X  0.531
2001 Hu J, Roy SK, Shapiro PS, Rodig SR, Reddy SP, Platanias LC, Schreiber RD, Kalvakolanu DV. ERK1 and ERK2 activate CCAAAT/enhancer-binding protein-beta-dependent gene transcription in response to interferon-gamma. The Journal of Biological Chemistry. 276: 287-97. PMID 10995751 DOI: 10.1074/Jbc.M004885200  0.404
2000 Alsayed Y, Uddin S, Mahmud N, Lekmine F, Kalvakolanu DV, Minucci S, Bokoch G, Platanias LC. Activation of Rac1 and the p38 mitogen-activated protein kinase pathway in response to all-trans-retinoic acid. The Journal of Biological Chemistry. 276: 4012-9. PMID 11060298 DOI: 10.1074/Jbc.M007431200  0.425
2000 Uddin S, Kottegoda S, Stigger D, Platanias LC, Wickrema A. Activation of the Akt/FKHRL1 pathway mediates the antiapoptotic effects of erythropoietin in primary human erythroid progenitors Biochemical and Biophysical Research Communications. 275: 16-19. PMID 10944433 DOI: 10.1006/Bbrc.2000.3266  0.522
2000 Du J, Alsayed YM, Xin F, Ackerman SJ, Platanias LC. Engagement of the CrkL adapter in interleukin-5 signaling in eosinophils. The Journal of Biological Chemistry. 275: 33167-75. PMID 10926930 DOI: 10.1074/Jbc.M003655200  0.383
2000 Alsayed Y, Modi S, Uddin S, Mahmud N, Druker BJ, Fish EN, Hoffman R, Platanias LC. All-trans-retinoic acid induces tyrosine phosphorylation of the CrkL adapter in acute promyelocytic leukemia cells. Experimental Hematology. 28: 826-32. PMID 10907644 DOI: 10.1016/S0301-472X(00)00170-3  0.467
2000 Uddin S, Lekmine F, Sharma N, Majchrzak B, Mayer I, Young PR, Bokoch GM, Fish EN, Platanias LC. The Rac1/p38 mitogen-activated protein kinase pathway is required for interferon alpha-dependent transcriptional activation but not serine phosphorylation of Stat proteins. The Journal of Biological Chemistry. 275: 27634-40. PMID 10878008 DOI: 10.1074/Jbc.M003170200  0.54
2000 Uddin S, Majchrzak B, Wang PC, Modi S, Khan MK, Fish EN, Platanias LC. Interferon-dependent activation of the serine kinase PI 3'-kinase requires engagement of the IRS pathway but not the Stat pathway. Biochemical and Biophysical Research Communications. 270: 158-62. PMID 10733921 DOI: 10.1006/Bbrc.2000.2402  0.534
2000 Alsayed Y, Uddin S, Ahmad S, Majchrzak B, Druker BJ, Fish EN, Platanias LC. IFN-gamma activates the C3G/Rap1 signaling pathway. Journal of Immunology (Baltimore, Md. : 1950). 164: 1800-6. PMID 10657627 DOI: 10.4049/Jimmunol.164.4.1800  0.488
1999 Platanias LC, Fish EN. Signaling pathways activated by interferons. Experimental Hematology. 27: 1583-92. PMID 10560905 DOI: 10.1016/S0301-472X(99)00109-5  0.53
1999 Uddin S, Majchrzak B, Woodson J, Arunkumar P, Alsayed Y, Pine R, Young PR, Fish EN, Platanias LC. Activation of the p38 mitogen-activated protein kinase by type I interferons. The Journal of Biological Chemistry. 274: 30127-31. PMID 10514501 DOI: 10.1074/Jbc.274.42.30127  0.544
1999 Wickrema A, Uddin S, Sharma A, Chen F, Alsayed Y, Ahmad S, Sawyer ST, Krystal G, Yi T, Nishada K, Hibi M, Hirano T, Platanias LC. Engagement of Gab1 and Gab2 in erythropoietin signaling. The Journal of Biological Chemistry. 274: 24469-74. PMID 10455108 DOI: 10.1074/Jbc.274.35.24469  0.458
1999 Grumbach IM, Fish EN, Uddin S, Majchrzak B, Colamonici OR, Figulla HR, Heim A, Platanias LC. Activation of the Jak-Stat pathway in cells that exhibit selective sensitivity to the antiviral effects of IFN-beta compared with IFN-alpha. Journal of Interferon & Cytokine Research : the Official Journal of the International Society For Interferon and Cytokine Research. 19: 797-801. PMID 10454351 DOI: 10.1089/107999099313659  0.429
1999 Platanias LC, Uddin S, Bruno E, Korkmaz M, Ahmad S, Alsayed Y, Van Den Berg D, Druker BJ, Wickrema A, Hoffman R. CrkL and CrkII participate in the generation of the growth inhibitory effects of interferons on primary hematopoietic progenitors. Experimental Hematology. 27: 1315-21. PMID 10428508 DOI: 10.1016/S0301-472X(99)00060-0  0.537
1999 Wickrema A, Chen F, Namin F, Yi T, Ahmad S, Uddin S, Chen YH, Feldman L, Stock W, Hoffman R, Platanias LC. Defective expression of the SHP-1 phosphatase in polycythemia vera. Experimental Hematology. 27: 1124-32. PMID 10390187 DOI: 10.1016/S0301-472X(99)00043-0  0.37
1999 Nadeau OW, Domanski P, Usacheva A, Uddin S, Platanias LC, Pitha P, Raz R, Levy D, Majchrzak B, Fish E, Colamonici OR. The proximal tyrosines of the cytoplasmic domain of the beta chain of the type I interferon receptor are essential for signal transducer and activator of transcription (Stat) 2 activation. Evidence that two Stat2 sites are required to reach a threshold of interferon alpha-induced Stat2 tyrosine phosphorylation that allows normal formation of interferon-stimulated gene factor 3. The Journal of Biological Chemistry. 274: 4045-52. PMID 9933596 DOI: 10.1074/Jbc.274.7.4045  0.434
1999 Fish EN, Uddin S, Korkmaz M, Majchrzak B, Druker BJ, Platanias LC. Activation of a CrkL-stat5 signaling complex by type I interferons. The Journal of Biological Chemistry. 274: 571-3. PMID 9872990 DOI: 10.1074/Jbc.274.2.571  0.483
1999 Chen Y, Lavelle D, DeSimone J, Uddin S, Platanias LC, Hankewych M. Growth Inhibition of a Human Myeloma Cell Line by All-transRetinoic Acid Is Not Mediated Through Downregulation of Interleukin-6 Receptors but Through Upregulation of p21WAF1 Blood. 94: 251-259. DOI: 10.1182/Blood.V94.1.251.413K42_251_259  0.314
1998 Saleh MN, LeMaistre CF, Kuzel TM, Foss F, Platanias LC, Schwartz G, Ratain M, Rook A, Freytes CO, Craig F, Reuben J, Sams MW, Nichols JC. Antitumor activity of DAB389IL-2 fusion toxin in mycosis fungoides Journal of the American Academy of Dermatology. 39: 63-73. PMID 9674399 DOI: 10.1016/S0190-9622(98)70403-7  0.306
1998 Uddin S, Grumbach IM, Yi T, Colamonici OR, Platanias LC. Interferon alpha activates the tyrosine kinase Lyn in haemopoietic cells. British Journal of Haematology. 101: 446-9. PMID 9633884 DOI: 10.1046/J.1365-2141.1998.00731.X  0.398
1998 Tabrizi M, Yang W, Jiao H, Devries EMG, Platanias LC, Arico M, Yi T. Reduced Tyk2/SHP-1 interaction and lack of SHP-1 mutation in a kindred of familial hemophagocytic lymphohistiocytosis. Leukemia. 12: 200-206. PMID 9519782 DOI: 10.1038/Sj.Leu.2400949  0.377
1998 Platanias LC, Domanski P, Nadeau OW, Yi T, Uddin S, Fish E, Neel BG, Colamonici OR. Identification of a domain in the beta subunit of the type I interferon (IFN) receptor that exhibits a negative regulatory effect in the growth inhibitory action of type I IFNs. The Journal of Biological Chemistry. 273: 5577-81. PMID 9488684 DOI: 10.1074/Jbc.273.10.5577  0.408
1998 Domanski P, Nadeau OW, Platanias LC, Fish E, Kellum M, Pitha P, Colamonici OR. Differential use of the betaL subunit of the type I interferon (IFN) receptor determines signaling specificity for IFNalpha2 and IFNbeta. The Journal of Biological Chemistry. 273: 3144-7. PMID 9452423 DOI: 10.1074/Jbc.273.6.3144  0.33
1998 Sun WH, Pabon C, Alsayed Y, Huang PP, Jandeska S, Uddin S, Platanias LC, Rosen ST. Interferon-α Resistance in a Cutaneous T-Cell Lymphoma Cell Line Is Associated With Lack of STAT1 Expression Blood. 91: 570-576. DOI: 10.1182/Blood.V91.2.570.570_570_576  0.459
1997 Ahmad S, Alsayed YM, Druker BJ, Platanias LC. The type I interferon receptor mediates tyrosine phosphorylation of the CrkL adaptor protein. The Journal of Biological Chemistry. 272: 29991-4. PMID 9374471 DOI: 10.1074/Jbc.272.48.29991  0.514
1997 Domanski P, Fish E, Nadeau OW, Witte M, Platanias LC, Yan H, Krolewski J, Pitha P, Colamonici OR. A region of the beta subunit of the interferon alpha receptor different from box 1 interacts with Jak1 and is sufficient to activate the Jak-Stat pathway and induce an antiviral state. The Journal of Biological Chemistry. 272: 26388-93. PMID 9334213 DOI: 10.1074/Jbc.272.42.26388  0.336
1997 Uddin S, Sher DA, Alsayed Y, Pons S, Colamonici OR, Fish EN, White MF, Platanias LC. Interaction of p59fyn with interferon-activated Jak kinases. Biochemical and Biophysical Research Communications. 235: 83-8. PMID 9196040 DOI: 10.1006/Bbrc.1997.6741  0.436
1997 Nichols J, Foss F, Kuzel TM, LeMaistre CF, Platanias L, Ratain MJ, Rook A, Saleh M, Schwartz G. Interleukin-2 fusion protein: an investigational therapy for interleukin-2 receptor expressing malignancies. European Journal of Cancer (Oxford, England : 1990). S34-6. PMID 9166099 DOI: 10.1016/S0959-8049(96)00327-9  0.321
1997 Uddin S, Sweet M, Colamonici OR, Krolewski JJ, Platanias LC. The vav proto-oncogene product (p95vav) interacts with the Tyk-2 protein tyrosine kinase. Febs Letters. 403: 31-4. PMID 9038355 DOI: 10.1016/S0014-5793(97)00023-9  0.473
1997 Uddin S, Fish EN, Sher D, Gardziola C, Colamonici OR, Kellum M, Pitha PM, White MF, Platanias LC. The IRS-pathway operates distinctively from the stat-pathway in hematopoietic cells and transduces common and distinct signals during engagement of the insulin or interferon-α receptors Blood. 90: 2574-2582. DOI: 10.1182/Blood.V90.7.2574.2574_2574_2582  0.436
1996 Jiao H, Berrada K, Yang W, Tabrizi M, Platanias LC, Yi T. Direct Association With And Dephosphorylation Of Jak2 Kinase By The Sh2-Domain-Containing Protein Tyrosine Phosphatase Shp-1 Molecular and Cellular Biology. 16: 6985-6992. PMID 8943354 DOI: 10.1128/Mcb.16.12.6985  0.447
1996 Platanias LC, Uddin S, Domanski P, Colamonici OR. Differences in interferon alpha and beta signaling. Interferon beta selectively induces the interaction of the alpha and betaL subunits of the type I interferon receptor. The Journal of Biological Chemistry. 271: 23630-3. PMID 8798579 DOI: 10.1074/Jbc.271.39.23630  0.359
1996 Uddin S, Gardziola C, Dangat A, Yi T, Platanias LC. Interaction of the c-cbl proto-oncogene product with the Tyk-2 protein tyrosine kinase. Biochemical and Biophysical Research Communications. 225: 833-8. PMID 8780698 DOI: 10.1006/Bbrc.1996.1259  0.361
1996 Platanias LC, Uddin S, Yetter A, Sun XJ, White MF. The type I interferon receptor mediates tyrosine phosphorylation of insulin receptor substrate 2. The Journal of Biological Chemistry. 271: 278-82. PMID 8550573 DOI: 10.1074/Jbc.271.1.278  0.321
1995 Colamonici OR, Platanias LC, Domanski P, Handa R, Gilmour KC, Diaz MO, Reich N, Pitha-Rowe P. Transmembrane signaling by the α subunit of the type I interferon receptor is essential for activation of the Jak kinases and the transcriptional factor ISGF3 Journal of Biological Chemistry. 270: 8188-8193. PMID 7713924 DOI: 10.1074/Jbc.270.14.8188  0.383
1995 Yetter A, Uddin S, Krolewski JJ, Jiao H, Yi T, Platanias LC. Association of the interferon-dependent tyrosine kinase Tyk-2 with the hematopoietic cell phosphatase. The Journal of Biological Chemistry. 270: 18179-82. PMID 7629131 DOI: 10.1074/Jbc.270.31.18179  0.411
1995 Uddin S, Chamdin A, Platanias LC. Interaction of the transcriptional activator Stat-2 with the type I interferon receptor. The Journal of Biological Chemistry. 270: 24627-30. PMID 7559568 DOI: 10.1074/jbc.270.42.24627  0.339
1995 Platanias LC. Interferons Current Opinion in Oncology. 7: 560-565. DOI: 10.1097/00001622-199511000-00015  0.425
1992 Colamonici O, Domanski P, Platanias L, Diaz M. Correlation between interferon (IFN) alpha resistance and deletion of the IFN alpha/beta genes in acute leukemia cell lines suggests selection against the IFN system Blood. 80: 744-749. DOI: 10.1182/Blood.V80.3.744.744  0.336
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