Karl X. Chai - Publications

Affiliations: 
University of Central Florida, Orlando, FL, United States 
Area:
Molecular Biology, Cell Biology, Oncology

36 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Chen LM, Chai KX. Matriptase cleaves the amyloid-beta peptide 1-42 at Arg-5, Lys-16, and Lys-28. Bmc Research Notes. 12: 5. PMID 30606244 DOI: 10.1186/S13104-018-4040-Z  0.322
2017 Chen LM, Chai KX. Proteolytic cleavages in the extracellular domain of receptor tyrosine kinases by membrane-associated serine proteases. Oncotarget. 8: 56490-56505. PMID 28915606 DOI: 10.18632/Oncotarget.17009  0.418
2017 Chen LM, Chai KX. Proteolytic cleavages in the extracellular domain of receptor tyrosine kinases by membrane-associated serine proteases. Oncotarget. PMID 28454094 DOI: 10.18632/oncotarget.17009  0.315
2015 Chai AC, Robinson AL, Chai KX, Chen LM. Ibuprofen regulates the expression and function of membrane-associated serine proteases prostasin and matriptase. Bmc Cancer. 15: 1025. PMID 26715240 DOI: 10.1186/S12885-015-2039-6  0.384
2014 D'Angelo RC, Liu XW, Najy AJ, Jung YS, Won J, Chai KX, Fridman R, Kim HR. TIMP-1 via TWIST1 induces EMT phenotypes in human breast epithelial cells. Molecular Cancer Research : McR. 12: 1324-33. PMID 24895412 DOI: 10.1158/1541-7786.Mcr-14-0105  0.381
2013 Chen LM, Nergard JC, Ni L, Rosser CJ, Chai KX. Long-term exposure to cigarette smoke extract induces hypomethylation at the RUNX3 and IGF2-H19 loci in immortalized human urothelial cells. Plos One. 8: e65513. PMID 23724145 DOI: 10.1371/Journal.Pone.0065513  0.31
2012 Fu YY, Nergard JC, Barnette NK, Wang YL, Chai KX, Chen LM. Proteasome inhibition augments cigarette smoke-induced GM-CSF expression in trophoblast cells via the epidermal growth factor receptor. Plos One. 7: e43042. PMID 22912784 DOI: 10.1371/Journal.Pone.0043042  0.442
2011 Xu Z, Chen YW, Battu A, Wilder P, Weber D, Yu W, Mackerell AD, Chen LM, Chai KX, Johnson MD, Lin CY. Targeting zymogen activation to control the matriptase-prostasin proteolytic cascade. Journal of Medicinal Chemistry. 54: 7567-78. PMID 21966950 DOI: 10.1021/Jm200920S  0.307
2011 Chai K, Kitamura K, McCann A, Wu XR. The epithelium—molecular landscaping for an interactive barrier. Journal of Biomedicine & Biotechnology. 2010: 870506. PMID 21527989 DOI: 10.1155/2010/870506  0.342
2010 Chen YW, Wang JK, Chou FP, Chen CY, Rorke EA, Chen LM, Chai KX, Eckert RL, Johnson MD, Lin CY. Regulation of the matriptase-prostasin cell surface proteolytic cascade by hepatocyte growth factor activator inhibitor-1 during epidermal differentiation. The Journal of Biological Chemistry. 285: 31755-62. PMID 20696767 DOI: 10.1074/Jbc.M110.150367  0.375
2010 Gao L, Smith RS, Chen LM, Chai KX, Chao L, Chao J. Tissue kallikrein promotes prostate cancer cell migration and invasion via a protease-activated receptor-1-dependent signaling pathway. Biological Chemistry. 391: 803-12. PMID 20482314 DOI: 10.1515/Bc.2010.084  0.451
2010 Fu YY, Gao WL, Chen M, Chai KX, Wang YL, Chen LM. Prostasin regulates human placental trophoblast cell proliferation via the epidermal growth factor receptor signaling pathway. Human Reproduction (Oxford, England). 25: 623-32. PMID 20089521 DOI: 10.1093/Humrep/Dep457  0.658
2010 Chen M, Chen LM, Lin CY, Chai KX. Hepsin activates prostasin and cleaves the extracellular domain of the epidermal growth factor receptor. Molecular and Cellular Biochemistry. 337: 259-66. PMID 19911255 DOI: 10.1007/S11010-009-0307-Y  0.651
2009 Chen LM, Verity NJ, Chai KX. Loss of prostasin (PRSS8) in human bladder transitional cell carcinoma cell lines is associated with epithelial-mesenchymal transition (EMT). Bmc Cancer. 9: 377. PMID 19849847 DOI: 10.1186/1471-2407-9-377  0.418
2009 Ma XJ, Fu YY, Li YX, Chen LM, Chai K, Wang YL. Prostasin inhibits cell invasion in human choriocarcinomal JEG-3 cells. Histochemistry and Cell Biology. 132: 639-46. PMID 19847458 DOI: 10.1007/S00418-009-0652-7  0.386
2009 Chen LM, Hatfield ML, Fu YY, Chai KX. Prostasin regulates iNOS and cyclin D1 expression by modulating protease-activated receptor-2 signaling in prostate epithelial cells. The Prostate. 69: 1790-801. PMID 19670249 DOI: 10.1002/Pros.21030  0.45
2008 Chen M, Chen LM, Lin CY, Chai KX. The epidermal growth factor receptor (EGFR) is proteolytically modified by the Matriptase-Prostasin serine protease cascade in cultured epithelial cells. Biochimica Et Biophysica Acta. 1783: 896-903. PMID 18054338 DOI: 10.1016/J.Bbamcr.2007.10.019  0.672
2007 Zhang H, Lin HY, Yang Q, Wang HX, Chai KX, Chen LM, Zhu C. Expression of prostasin serine protease and protease nexin-1 (PN-1) in rhesus monkey ovary during menstrual cycle and early pregnancy. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 55: 1237-44. PMID 17827166 DOI: 10.1369/Jhc.7A7232.2007  0.319
2007 Chen M, Fu YY, Lin CY, Chen LM, Chai KX. Prostasin induces protease-dependent and independent molecular changes in the human prostate carcinoma cell line PC-3. Biochimica Et Biophysica Acta. 1773: 1133-40. PMID 17532063 DOI: 10.1016/J.Bbamcr.2007.04.013  0.682
2006 Netzel-Arnett S, Currie BM, Szabo R, Lin CY, Chen LM, Chai KX, Antalis TM, Bugge TH, List K. Evidence for a matriptase-prostasin proteolytic cascade regulating terminal epidermal differentiation. The Journal of Biological Chemistry. 281: 32941-5. PMID 16980306 DOI: 10.1074/Jbc.C600208200  0.389
2006 Chen M, Chen LM, Chai KX. Mechanisms of sterol regulatory element-binding protein-2 (SREBP-2) regulation of human prostasin gene expression. Biochemical and Biophysical Research Communications. 346: 1245-53. PMID 16806080 DOI: 10.1016/J.Bbrc.2006.06.049  0.644
2006 Lin HY, Zhang H, Yang Q, Wang HX, Wang HM, Chai KX, Chen LM, Zhu C. Expression of prostasin and protease nexin-1 in rhesus monkey (Macaca mulatta) endometrium and placenta during early pregnancy. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 54: 1139-47. PMID 16801525 DOI: 10.1369/Jhc.6A7005.2006  0.312
2006 Chen LM, Wang C, Chen M, Marcello MR, Chao J, Chao L, Chai KX. Prostasin attenuates inducible nitric oxide synthase expression in lipopolysaccharide-induced urinary bladder inflammation. American Journal of Physiology. Renal Physiology. 291: F567-77. PMID 16638913 DOI: 10.1152/Ajprenal.00047.2006  0.62
2006 Chen M, Chen LM, Chai KX. Androgen regulation of prostasin gene expression is mediated by sterol-regulatory element-binding proteins and SLUG. The Prostate. 66: 911-20. PMID 16541421 DOI: 10.1002/Pros.20325  0.647
2004 Chen LM, Zhang X, Chai KX. Regulation of prostasin expression and function in the prostate. The Prostate. 59: 1-12. PMID 14991861 DOI: 10.1002/Pros.10346  0.369
2002 Narikiyo T, Kitamura K, Adachi M, Miyoshi T, Iwashita K, Shiraishi N, Nonoguchi H, Chen LM, Chai KX, Chao J, Tomita K. Regulation of prostasin by aldosterone in the kidney. The Journal of Clinical Investigation. 109: 401-8. PMID 11828000 DOI: 10.1172/Jci13229  0.329
2002 Chen LM, Chai KX. Prostasin serine protease inhibits breast cancer invasiveness and is transcriptionally regulated by promoter DNA methylation. International Journal of Cancer. 97: 323-9. PMID 11774283 DOI: 10.1002/Ijc.1601  0.376
2001 Chen LM, Byron Hodge G, Guarda LA, Welch JL, Greenberg NM, Chai KX. Down-regulation of prostasin serine protease: A potential invasion suppressor in prostate cancer Prostate. 48: 93-103. PMID 11433419 DOI: 10.1002/Pros.1085  0.387
2001 Chen LM, Skinner ML, Kauffman SW, Chao J, Chao L, Thaler CD, Chai KX. Prostasin is a glycosylphosphatidylinositol-anchored active serine protease. The Journal of Biological Chemistry. 276: 21434-42. PMID 11274175 DOI: 10.1074/Jbc.M011423200  0.328
2000 Silva JA, Araujo RC, Baltatu O, Oliveira SM, Tschöpe C, Fink E, Hoffmann S, Plehm R, Chai KX, Chao L, Chao J, Ganten D, Pesquero JB, Bader M. Reduced cardiac hypertrophy and altered blood pressure control in transgenic rats with the human tissue kallikrein gene. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 14: 1858-60. PMID 11023967 DOI: 10.1096/Fj.99-1010Fje  0.308
1998 Ni A, Chai KX, Chao L, Chao J. Molecular cloning and expression of rat bradykinin B1 receptor. Biochimica Et Biophysica Acta. 1442: 177-85. PMID 9804950 DOI: 10.1016/S0167-4781(98)00163-8  0.36
1997 Chai KX, Chen VC, Ni A, Lindpaintner K, Rubattu S, Chao L, Chao J. Molecular cloning and expression of rat kallistatin gene. Biochimica Et Biophysica Acta. 1353: 277-86. PMID 9349723 DOI: 10.1016/S0167-4781(97)00100-0  0.319
1997 Chao J, Chai KX, Chao L. Tissue kallikrein inhibitors in mammals. Immunopharmacology. 32: 67-72. PMID 8796269 DOI: 10.1016/0162-3109(96)00010-0  0.358
1996 Chai KX, Ni A, Wang D, Ward DC, Chao J, Chao L. Genomic DNA sequence, expression, and chromosomal localization of the human B1 bradykinin receptor gene BDKRB1. Genomics. 31: 51-7. PMID 8808279 DOI: 10.1006/Geno.1996.0008  0.346
1995 Chai KX, Ward DC, Chao J, Chao L. Molecular cloning, sequence analysis, and chromosomal localization of the human protease inhibitor 4 (kallistatin) gene (PI4). Genomics. 23: 370-8. PMID 7835886 DOI: 10.1006/Geno.1994.1513  0.348
1992 Chai KX, Chao J, Chao L. Molecular cloning and sequence analysis of the mouse kallikrein-binding protein gene. Biochimica Et Biophysica Acta. 1129: 127-30. PMID 1756173 DOI: 10.1016/0167-4781(91)90227-D  0.306
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