Robert A. Sikes - Publications

Affiliations: 
Department of Biological Sciences University of Delaware, Newark, DE, United States 
Area:
Physiology Biology, Cell Biology, Molecular Biology

61 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Pradhan L, Moore D, Ovadia EM, Swedzinski SL, Cossette T, Sikes RA, van Golen K, Kloxin AM. Dynamic bioinspired coculture model for probing ER breast cancer dormancy in the bone marrow niche. Science Advances. 9: eade3186. PMID 36888709 DOI: 10.1126/sciadv.ade3186  0.339
2017 Lertsuwan K, Peters W, Johnson L, Lertsuwan J, Marwa I, Sikes RA. Purinergic Receptor Expression and Cellular Responses to Purinergic Agonists in Human Prostate Cancer Cells. Anticancer Research. 37: 529-537. PMID 28179298 DOI: 10.21873/Anticanres.11345  0.816
2017 Lertsuwan K, Choe LH, Marwa IR, Lee K, Sikes RA. Identification of Fibulin-1 as a Human Bone Marrow Stromal (HS-5) Sell-Derived Factor That Induces Human Prostate Cancer Cell Death. The Prostate. PMID 28168724 DOI: 10.1002/Pros.23303  0.476
2015 Miles FL, Lynch JE, Sikes RA. Cell-based assays using calcein acetoxymethyl ester show variation in fluorescence with treatment conditions. Journal of Biological Methods. 2. PMID 26937420 DOI: 10.14440/jbm.2015.73  0.675
2015 Miles FL, Kurtoglu S, Ahmer C, Soori M, Favate JS, Sikes RA. Transforming growth factor-β signaling induced during prostate cancer cell death and neuroendocrine differentiation is mediated by bone marrow stromal cells. The Prostate. 75: 1802-13. PMID 26392321 DOI: 10.1002/Pros.23060  0.819
2014 Jansson KH, Castillo DG, Morris JW, Boggs ME, Czymmek KJ, Adams EL, Schramm LP, Sikes RA. Identification of beta-2 as a key cell adhesion molecule in PCa cell neurotropic behavior: a novel ex vivo and biophysical approach. Plos One. 9: e98408. PMID 24892658 DOI: 10.1371/Journal.Pone.0098408  0.783
2014 Miles FL, Sikes RA. Insidious changes in stromal matrix fuel cancer progression. Molecular Cancer Research : McR. 12: 297-312. PMID 24452359 DOI: 10.1158/1541-7786.Mcr-13-0535  0.777
2013 Dong X, Xu W, Sikes RA, Wu C. Combination of low dose of genistein and daidzein has synergistic preventive effects on isogenic human prostate cancer cells when compared with individual soy isoflavone. Food Chemistry. 141: 1923-33. PMID 23870911 DOI: 10.1016/J.Foodchem.2013.04.109  0.484
2013 Lertsuwan J, Sikes R. Abstract P2-09-20: 2’(3’)-O-(4-benzoylbenzoyl)adenosine 5’-triphosphate (BzATP) is a potential drug for triple negative breast cancer: Autophagy and apoptosis inducer Cancer Research. 73. DOI: 10.1158/0008-5472.Sabcs13-P2-09-20  0.422
2012 Dong X, Xu W, Sikes RA, Wu C. Apoptotic effects of cooked and in vitro digested soy on human prostate cancer cells. Food Chemistry. 135: 1643-52. PMID 22953905 DOI: 10.1016/J.Foodchem.2012.06.023  0.493
2012 Hillyer RL, Sirinvasin P, Joglekar M, Sikes RA, van Golen KL, Nohe A. Differential effects of vitamin D treatment on inflammatory and non-inflammatory breast cancer cell lines. Clinical & Experimental Metastasis. 29: 971-9. PMID 22610818 DOI: 10.1007/S10585-012-9486-0  0.374
2012 Miles FL, Tung NS, Aguiar AA, Kurtoglu S, Sikes RA. Increased TGF-β1-mediated suppression of growth and motility in castrate-resistant prostate cancer cells is consistent with Smad2/3 signaling. The Prostate. 72: 1339-50. PMID 22228025 DOI: 10.1002/Pros.22482  0.778
2012 Jansson KH, Lynch JE, Lepori-Bui N, Czymmek KJ, Duncan RL, Sikes RA. Overexpression of the VSSC-associated CAM, β-2, enhances LNCaP cell metastasis associated behavior. The Prostate. 72: 1080-92. PMID 22127840 DOI: 10.1002/Pros.21512  0.798
2011 Zhang C, Soori M, Miles FL, Sikes RA, Carson DD, Chung LW, Farach-Carson MC. Paracrine factors produced by bone marrow stromal cells induce apoptosis and neuroendocrine differentiation in prostate cancer cells. The Prostate. 71: 157-67. PMID 20665531 DOI: 10.1002/Pros.21231  0.769
2011 Li Y, Sikes RA, Malaeb BS, Yeung F, Law A, Graham SE, Pei M, Kao C, Nelson J, Koeneman KS, Chung LW. Osteoblasts can stimulate prostate cancer growth and transcriptionally down-regulate PSA expression in cell line models. Urologic Oncology. 29: 802-8. PMID 20451417 DOI: 10.1016/J.Urolonc.2009.09.016  0.59
2010 Degraff DJ, Aguiar AA, Chen Q, Adams LK, Williams BJ, Sikes RA. Androgen mediated translational and postranslational regulation of IGFBP-2 in androgen-sensitive LNCaP human prostate cancer cells. American Journal of Translational Research. 2: 200-8. PMID 20407609  0.804
2010 Chen Q, DeGraff DJ, Sikes RA. The developmental expression profile of PAX2 in the murine prostate. The Prostate. 70: 654-65. PMID 20017165 DOI: 10.1002/Pros.21099  0.741
2010 Thalmann GN, Rhee H, Sikes RA, Pathak S, Multani A, Zhau HE, Marshall FF, Chung LW. Human prostate fibroblasts induce growth and confer castration resistance and metastatic potential in LNCaP Cells. European Urology. 58: 162-71. PMID 19747763 DOI: 10.1016/J.Eururo.2009.08.026  0.6
2010 Miles FL, Sikes RA. Abstract 3184: TGF-β1 signaling inhibits proliferation but promotes motility with progression to castrate-resistant prostate cancer Cancer Research. 70: 3184-3184. DOI: 10.1158/1538-7445.Am10-3184  0.805
2009 Degraff DJ, Aguiar AA, Sikes RA. Disease evidence for IGFBP-2 as a key player in prostate cancer progression and development of osteosclerotic lesions. American Journal of Translational Research. 1: 115-30. PMID 19956425  0.798
2009 Gomes RR, Buttke P, Paul EM, Sikes RA. Osteosclerotic prostate cancer metastasis to murine bone are enhanced with increased bone formation. Clinical & Experimental Metastasis. 26: 641-51. PMID 19421879 DOI: 10.1007/S10585-009-9263-X  0.431
2009 Chung SW, Miles FL, Sikes RA, Cooper CR, Farach-Carson MC, Ogunnaike BA. Quantitative modeling and analysis of the transforming growth factor beta signaling pathway. Biophysical Journal. 96: 1733-50. PMID 19254534 DOI: 10.1016/J.Bpj.2008.11.050  0.734
2009 Pritchard C, Mecham B, Dumpit R, Coleman I, Bhattacharjee M, Chen Q, Sikes RA, Nelson PS. Conserved gene expression programs integrate mammalian prostate development and tumorigenesis. Cancer Research. 69: 1739-47. PMID 19223557 DOI: 10.1158/0008-5472.Can-07-6817  0.556
2008 Cooper CR, Graves B, Pruitt F, Chaib H, Lynch JE, Cox AK, Sequeria L, van Golen KL, Evans A, Czymmek K, Bullard RS, Donald CD, Sol-Church K, Gendernalik JD, Weksler B, ... ... Sikes RA, et al. Novel surface expression of reticulocalbin 1 on bone endothelial cells and human prostate cancer cells is regulated by TNF-alpha. Journal of Cellular Biochemistry. 104: 2298-309. PMID 18561328 DOI: 10.1002/Jcb.21785  0.464
2007 Degraff DJ, Malik M, Chen Q, Miyako K, Rejto L, Aguiar AA, Bancroft DR, Cohen P, Sikes RA. Hormonal regulation of IGFBP-2 proteolysis is attenuated with progression to androgen insensitivity in the LNCaP progression model. Journal of Cellular Physiology. 213: 261-8. PMID 17492783 DOI: 10.1002/Jcp.21123  0.81
2007 Deeble PD, Cox ME, Frierson HF, Sikes RA, Palmer JB, Davidson RJ, Casarez EV, Amorino GP, Parsons SJ. Androgen-independent growth and tumorigenesis of prostate cancer cells are enhanced by the presence of PKA-differentiated neuroendocrine cells. Cancer Research. 67: 3663-72. PMID 17440078 DOI: 10.1158/0008-5472.Can-06-2616  0.595
2006 Fiske JL, Fomin VP, Brown ML, Duncan RL, Sikes RA. Voltage-sensitive ion channels and cancer. Cancer Metastasis Reviews. 25: 493-500. PMID 17111226 DOI: 10.1007/S10555-006-9017-Z  0.306
2006 Tate A, Isotani S, Bradley MJ, Sikes RA, Davis R, Chung LW, Edlund M. Met-Independent Hepatocyte Growth Factor-mediated regulation of cell adhesion in human prostate cancer cells. Bmc Cancer. 6: 197. PMID 16869958 DOI: 10.1186/1471-2407-6-197  0.642
2006 Chen Q, Watson JT, Marengo SR, Decker KS, Coleman I, Nelson PS, Sikes RA. Gene expression in the LNCaP human prostate cancer progression model: progression associated expression in vitro corresponds to expression changes associated with prostate cancer progression in vivo. Cancer Letters. 244: 274-88. PMID 16500022 DOI: 10.1016/J.Canlet.2005.12.027  0.48
2006 Thalmann G, Rhee H, Sikes R, Pathak S, Zhau H, Studer U, Chung L. INDUCTION OF PROSTATE CANCER CELL GROWTH, ANDROGENINDEPENDENCE AND BONE METASTASIS IN LNCAP CELLS BY HUMAN PROSTATE FIBROBLASTS OF DIFFERENT ZONAL ORIGIN European Urology Supplements. 5: 790. DOI: 10.1016/S1569-9056(06)61266-9  0.552
2006 Thalmann G, Rhee H, Sikes R, Pathak S, Zhau H, Studer U, Chung L. HUMAN PROSTATE FIBROBLASTS OF DIFFERENT ZONAL ORIGIN INDUCE LNCAP CELL PROLIFERATION, ANDROGEN INDEPENDENCE AND BONE METASTASIS European Urology Supplements. 5: 126. DOI: 10.1016/S1569-9056(06)60421-1  0.466
2006 Thalmann GN, Atlanta HR, Sikes R, Pathak S, Zhau HE, Studer UE, Chung LW. 414: Induction of LNCAP Cell Growth, Androgen-Independence and Bone Metastasis by Human Prostate Fibroblasts of Different Zonal Origin Journal of Urology. 175: 135-135. DOI: 10.1016/S0022-5347(18)32670-3  0.554
2004 Krueckl SL, Sikes RA, Edlund NM, Bell RH, Hurtado-Coll A, Fazli L, Gleave ME, Cox ME. Increased insulin-like growth factor I receptor expression and signaling are components of androgen-independent progression in a lineage-derived prostate cancer progression model. Cancer Research. 64: 8620-9. PMID 15574769 DOI: 10.1158/0008-5472.Can-04-2446  0.557
2004 Brennen WN, Cooper CR, Capitosti S, Brown ML, Sikes RA. Thalidomide and analogues: current proposed mechanisms and therapeutic usage. Clinical Prostate Cancer. 3: 54-61. PMID 15279692 DOI: 10.3816/Cgc.2004.N.014  0.488
2004 Sikes RA, Nicholson BE, Koeneman KS, Edlund NM, Bissonette EA, Bradley MJ, Thalmann GN, Cecchini MG, Pienta KJ, Chung LW. Cellular interactions in the tropism of prostate cancer to bone. International Journal of Cancer. Journal International Du Cancer. 110: 497-503. PMID 15122581 DOI: 10.1002/Ijc.20153  0.551
2004 Cooper CR, Sikes RA, Nicholson BE, Sun YX, Pienta KJ, Taichman RS. Cancer cells homing to bone: the significance of chemotaxis and cell adhesion. Cancer Treatment and Research. 118: 291-309. PMID 15043197 DOI: 10.1007/978-1-4419-9129-4_12  0.481
2004 Stewart DA, Cooper CR, Sikes RA. Changes in extracellular matrix (ECM) and ECM-associated proteins in the metastatic progression of prostate cancer. Reproductive Biology and Endocrinology : Rb&E. 2: 2. PMID 14711377 DOI: 10.1186/1477-7827-2-2  0.574
2003 Sikes RA, Walls AM, Brennen WN, Anderson JD, Choudhury-Mukherjee I, Schenck HA, Brown ML. Therapeutic approaches targeting prostate cancer progression using novel voltage-gated ion channel blockers. Clinical Prostate Cancer. 2: 181-7. PMID 15040863 DOI: 10.3816/Cgc.2003.N.028  0.591
2003 Abbott DE, Pritchard C, Clegg NJ, Ferguson C, Dumpit R, Sikes RA, Nelson PS. Expressed sequence tag profiling identifies developmental and anatomic partitioning of gene expression in the mouse prostate. Genome Biology. 4: R79. PMID 14659016 DOI: 10.1186/Gb-2003-4-12-R79  0.489
2003 Anderson JD, Hansen TP, Lenkowski PW, Walls AM, Choudhury IM, Schenck HA, Friehling M, Höll GM, Patel MK, Sikes RA, Brown ML. Voltage-gated sodium channel blockers as cytostatic inhibitors of the androgen-independent prostate cancer cell line PC-3. Molecular Cancer Therapeutics. 2: 1149-54. PMID 14617788  0.398
2003 Tennant MK, Vessella RL, Sprenger CC, Sikes RA, Hwa V, Baker LD, Plymate SR. Insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1/mac 25) is reduced in human prostate cancer and is inversely related to tumor volume and proliferation index in Lucap 23.12 xenografts. The Prostate. 56: 115-22. PMID 12746836 DOI: 10.1002/Pros.10223  0.548
2003 Bakin RE, Gioeli D, Sikes RA, Bissonette EA, Weber MJ. Constitutive activation of the Ras/mitogen-activated protein kinase signaling pathway promotes androgen hypersensitivity in LNCaP prostate cancer cells. Cancer Research. 63: 1981-9. PMID 12702592  0.446
2003 Guo N, Ye JJ, Liang SJ, Mineo R, Li SL, Giannini S, Plymate SR, Sikes RA, Fujita-Yamaguchi Y. The role of insulin-like growth factor-II in cancer growth and progression evidenced by the use of ribozymes and prostate cancer progression models. Growth Hormone & Igf Research : Official Journal of the Growth Hormone Research Society and the International Igf Research Society. 13: 44-53. PMID 12550081 DOI: 10.1016/S1096-6374(02)00121-1  0.607
2003 Thalmann G, Sikes R, Bisoffi M, Nelson P, Wetterwald A, Studer U, Cecchini M. Gene expression profiles in the LNCAP model of human prostate cancer progression: Upregulation of osteomimetic peptides European Urology Supplements. 2: 58. DOI: 10.1016/S1569-9056(03)80230-0  0.407
2000 Thalmann GN, Sikes RA, Wu TT, Degeorges A, Chang SM, Ozen M, Pathak S, Chung LW. LNCaP progression model of human prostate cancer: androgen-independence and osseous metastasis. The Prostate. 44: 91-103 Jul 1;44(2). PMID 10881018 DOI: 10.1002/1097-0045(20000701)44:2<91::Aid-Pros1>3.0.Co;2-L  0.624
2000 Degeorges A, Wang F, Frierson HF, Seth A, Sikes RA. Distribution of IGFBP-rP1 in normal human tissues Journal of Histochemistry and Cytochemistry. 48: 747-754. PMID 10820148 DOI: 10.1177/002215540004800603  0.444
1999 Hyytinen ER, Frierson HF, Sipe TW, Li CL, Degeorges A, Sikes RA, Chung LWK, Dong JT. Loss of heterozygosity and lack of mutations of the XPG/ERCC5 DNA repair gene at 13q33 in prostate cancer Prostate. 41: 190-195. PMID 10517877 DOI: 10.1002/(Sici)1097-0045(19991101)41:3<190::Aid-Pros6>3.0.Co;2-2  0.507
1999 Theodorescu D, Frierson HF, Sikes RA. Molecular determination of surgical margins using fossa biopsies at radical prostatectomy Journal of Urology. 161: 1442-1448. PMID 10210369 DOI: 10.1016/S0022-5347(05)68919-7  0.517
1999 Koeneman KS, Yeung F, Sikes RA, Chung LWK, Nelson JB. TRANSCRIPTIONAL DOWNREGULATION OF PSA, AND ENHANCED GROWTH OF PROSTATE CANCER (CaP) CELLS BY CO-CULTURE WITH OSTEOBLASTIC CELLS The Journal of Urology. 99. DOI: 10.1097/00005392-199904010-00397  0.61
1999 Zhau HE, Li C, Yang H, Dong J, Frierson H, Sikes RA, Wang Y, Sipe TW, Chung LWK. Genotypic Comparison Of Prostate Cancers Among U.S. Whites, U.S. Blacks, And Mainland Chinese Men The Journal of Urology. 70. DOI: 10.1097/00005392-199904010-00284  0.447
1998 Wu TT, Sikes RA, Cui Q, Thalmann GN, Kao C, Murphy CF, Yang H, Zhau HE, Balian G, Chung LW. Establishing human prostate cancer cell xenografts in bone: induction of osteoblastic reaction by prostate-specific antigen-producing tumors in athymic and SCID/bg mice using LNCaP and lineage-derived metastatic sublines. International Journal of Cancer. Journal International Du Cancer. 77: 887-94. PMID 9714059 DOI: 10.1002/(Sici)1097-0215(19980911)77:6<887::Aid-Ijc15>3.0.Co;2-Z  0.558
1998 Chen ME, Lin SH, Chung LW, Sikes RA. Isolation and characterization of PAGE-1 and GAGE-7. New genes expressed in the LNCaP prostate cancer progression model that share homology with melanoma-associated antigens. The Journal of Biological Chemistry. 273: 17618-25. PMID 9651357 DOI: 10.1074/Jbc.273.28.17618  0.571
1998 Vafa A, Zhang Y, Sikes RA, Marengo SR. Overexpression of p185erbB2/neu in the NbE prostatic epithelial cell line increases cellular spreading and the expression of integrin alpha6beta1. International Journal of Oncology. 13: 1191-1197. DOI: 10.3892/Ijo.13.6.1191  0.546
1997 Cleutjens KBJM, Van Der Korput HAGM, Ehren-van Eekelen CC, Sikes RA, Fasciana C, Chung LW, Trapman J. A 6-kb promoter fragment mimics in transgenic mice the prostate-specific and androgen-regulated expression of the endogenous prostate-specific antigen gene in humans Molecular Endocrinology. 11: 1256-1265. PMID 9259317 DOI: 10.1210/Mend.11.9.9974  0.516
1997 Marengo SR, Sikes RA, Anezinis P, Chang SM, Chung LW. Metastasis induced by overexpression of p185neu-T after orthotopic injection into a prostatic epithelial cell line (NbE). Molecular Carcinogenesis. 19: 165-75. PMID 9254883 DOI: 10.1002/(Sici)1098-2744(199707)19:3<165::Aid-Mc4>3.0.Co;2-D  0.533
1996 Thalmann GN, Sikes RA, Chang SM, Johnston DA, von Eschenbach AC, Chung LW. Suramin-induced decrease in prostate-specific antigen expression with no effect on tumor growth in the LNCaP model of human prostate cancer. Journal of the National Cancer Institute. 88: 794-801. PMID 8637045 DOI: 10.1093/Jnci/88.12.794  0.577
1996 Zhau HY, Zhou J, Symmans WF, Chen BQ, Chang SM, Sikes RA, Chung LW. Transfected neu oncogene induces human prostate cancer metastasis. The Prostate. 28: 73-83. PMID 8604395 DOI: 10.1002/(Sici)1097-0045(199602)28:2<73::Aid-Pros1>3.0.Co;2-O  0.56
1994 He XY, Sikes RA, Thomsen S, Chung LW, Jacques SL. Photodynamic therapy with photofrin II induces programmed cell death in carcinoma cell lines. Photochemistry and Photobiology. 59: 468-73. PMID 8022890 DOI: 10.1111/J.1751-1097.1994.Tb05066.X  0.372
1993 He XY, Sikes RA, Thomsen SLMD, Chung LW, Jacques SL. Photodynamic therapy-induced programmed cell death in carcinoma cell lines Proceedings of Spie. 1881: 285-295. DOI: 10.1117/12.146321  0.375
1992 Chung LW, Li W, Gleave ME, Hsieh JT, Wu HC, Sikes RA, Zhau HE, Bandyk MG, Logothetis CJ, Rubin JS. Human prostate cancer model: roles of growth factors and extracellular matrices Journal of Cellular Biochemistry. Supplement. 16: 99-105. PMID 1289680 DOI: 10.1002/Jcb.240501222  0.591
1990 Sikes RA, Thomsen S, Petrow V, Neubauer BL, Chung LW. Inhibition of experimentally induced mouse prostatic hyperplasia by castration or steroid antagonist administration. Biology of Reproduction. 43: 353-62. PMID 1696141 DOI: 10.1095/Biolreprod43.2.353  0.498
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