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Elias Georges - Publications

Affiliations: 
McGill University, Montreal, QC, Canada 
Area:
Pharmacology, Molecular Biology, Oncology
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52 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Baakdah F, Georges E. Epitope specific antibodies to N- and C cytoplasmic domains of the Plasmodium falciparum chloroquine resistance transporter (PfCRT) differentiate native and post-translationally modified variant. Biochemical and Biophysical Research Communications. 669: 54-60. PMID 37267860 DOI: 10.1016/j.bbrc.2023.05.096  0.357
2023 Bakadlag R, Limniatis G, Georges G, Georges E. The anti-estrogen receptor drug, tamoxifen, is selectively Lethal to P-glycoprotein-expressing Multidrug resistant tumor cells. Bmc Cancer. 23: 24. PMID 36609245 DOI: 10.1186/s12885-022-10474-x  0.478
2022 Limniatis G, Georges E. Down-regulation of ABCB1 by Collateral Sensitivity Drugs Reverses Multidrug Resistance and Up-regulates Enolase I. Journal of Biochemistry. PMID 35471238 DOI: 10.1093/jb/mvac032  0.422
2022 Limniatis G, Georges E. Knockout of P-glycoprotein abolish the collateral sensitivity of CHOC5 multidrug resistant cells. Biochemical and Biophysical Research Communications. 608: 23-29. PMID 35381425 DOI: 10.1016/j.bbrc.2022.03.148  0.395
2021 Limniatis G, Georges E. The phenothiazine, trifluoperazine, is selectively lethal to ABCB1-expressing multidrug resistant cells. Biochemical and Biophysical Research Communications. 570: 148-153. PMID 34284140 DOI: 10.1016/j.bbrc.2021.07.031  0.453
2021 Baakdah F, Georges E. Epitope-specific IgG pools identify PfCRT monomer and homodimer polypeptides that are differentially phosphorylated at Ser in Plasmodium falciparum. Biochemical and Biophysical Research Communications. 557: 261-266. PMID 33894412 DOI: 10.1016/j.bbrc.2021.04.034  0.333
2021 Georges E, Sottas C, Li Y, Papadopoulos V. Direct and specific binding of cholesterol to the mitochondrial translocator protein (TSPO) using PhotoClick cholesterol analogue. Journal of Biochemistry. PMID 33846725 DOI: 10.1093/jb/mvab031  0.345
2017 Fallatah O, Georges E. Apigenin-induced ABCC1-mediated efflux of glutathione from mature erythrocytes inhibits the proliferation of plasmodium falciparum. International Journal of Antimicrobial Agents. PMID 28807879 DOI: 10.1016/J.Ijantimicag.2017.08.014  0.401
2016 Ambadipudi R, Georges E. Sequences in Linker-1 domain of the multidrug resistance associated protein (MRP1 or ABCC1) bind to tubulin and their binding is modulated by phosphorylation. Biochemical and Biophysical Research Communications. PMID 27908733 DOI: 10.1016/J.Bbrc.2016.11.147  0.482
2016 Edaye S, Tazoo D, Bohle DS, Georges E. 3-Iodo-4-aminoquinoline derivative sensitises resistant strains of Plasmodium falciparum to chloroquine. International Journal of Antimicrobial Agents. PMID 27211211 DOI: 10.1016/J.Ijantimicag.2016.03.016  0.437
2016 Limniatis G, Georges E. Abstract 4683: Verapamil and tamoxifen modulate ABCB1 expression in multidrug-resistant cells and resensitize them to conventional chemotherapy Cancer Research. 76: 4683-4683. DOI: 10.1158/1538-7445.Am2016-4683  0.478
2015 Edaye S, Tazoo D, Bohle DS, Georges E. 3-halo Chloroquine Derivatives Overcome PfCRT-mediated Drug Resistance in Plasmodium falciparum. Antimicrobial Agents and Chemotherapy. PMID 26438496 DOI: 10.1128/Aac.01139-15  0.492
2015 Edaye S, Georges E. Characterization of native PfABCG protein in Plasmodium falciparum. Biochemical Pharmacology. 97: 137-46. PMID 26239803 DOI: 10.1016/J.Bcp.2015.06.035  0.395
2014 Edaye S, Reiling SJ, Leimanis ML, Wunderlich J, Rohrbach P, Georges E. A 2-amino quinoline, 5-(3-(2-(7-chloroquinolin-2-yl)ethenyl)phenyl)-8-dimethylcarbamyl-4,6-dithiaoctanoic acid, interacts with PfMDR1 and inhibits its drug transport in Plasmodium falciparum. Molecular and Biochemical Parasitology. 195: 34-42. PMID 24914817 DOI: 10.1016/J.Molbiopara.2014.05.006  0.524
2014 Georges E, Lian J, Laberge R. A tamoxifen derivative, N,N-diethyl-2-[4-(phenylmethyl) phenoxy] ethanamine, selectively targets P-glycoprotein-positive multidrug resistant Chinese hamster cells. Biochemical Pharmacology. 90: 107-14. PMID 24821111 DOI: 10.1016/J.Bcp.2014.04.017  0.473
2014 Laberge RM, Ambadipudi R, Georges E. P-glycoprotein mediates the collateral sensitivity of multidrug resistant cells to steroid hormones. Biochemical and Biophysical Research Communications. 447: 574-9. PMID 24747077 DOI: 10.1016/J.Bbrc.2014.04.045  0.46
2012 Yang Y, Li Z, Mo W, Ambadipudi R, Arnold RJ, Hrncirova P, Novotny MV, Georges E, Zhang JT. Human ABCC1 interacts and colocalizes with ATP synthase α, revealed by interactive proteomics analysis. Journal of Proteome Research. 11: 1364-72. PMID 22188235 DOI: 10.1021/Pr201003G  0.527
2011 Leimanis ML, Karwatsky J, Georges E. Photoaffinity labeling of the multidrug resistance protein 2 (ABCC2/cMOAT) with a photoreactive analog of LTC(4). International Journal of Biochemistry and Molecular Biology. 2: 39-46. PMID 21968553  0.553
2009 Laberge RM, Ambadipudi R, Georges E. P-glycoprotein (ABCB1) modulates collateral sensitivity of a multidrug resistant cell line to verapamil. Archives of Biochemistry and Biophysics. 491: 53-60. PMID 19772851 DOI: 10.1016/J.Abb.2009.09.012  0.505
2007 Georges E. The P-glycoprotein (ABCB1) linker domain encodes high-affinity binding sequences to alpha- and beta-tubulins. Biochemistry. 46: 7337-42. PMID 17530867 DOI: 10.1021/Bi7006228  0.488
2007 Laberge RM, Karwatsky J, Lincoln MC, Leimanis ML, Georges E. Modulation of GSH levels in ABCC1 expressing tumor cells triggers apoptosis through oxidative stress. Biochemical Pharmacology. 73: 1727-37. PMID 17359940 DOI: 10.1016/J.Bcp.2007.02.005  0.402
2007 Leimanis ML, Georges E. ABCG2 membrane transporter in mature human erythrocytes is exclusively homodimer. Biochemical and Biophysical Research Communications. 354: 345-50. PMID 17250810 DOI: 10.1016/J.Bbrc.2006.12.219  0.55
2005 Karwatsky J, Leimanis M, Cai J, Gros P, Georges E. The leucotriene C4 binding sites in multidrug resistance protein 1 (ABCC1) include the first membrane multiple spanning domain. Biochemistry. 44: 340-51. PMID 15628876 DOI: 10.1021/Bi048853H  0.618
2004 Alqawi O, Bates S, Georges E. Arginine482 to threonine mutation in the breast cancer resistance protein ABCG2 inhibits rhodamine 123 transport while increasing binding. The Biochemical Journal. 382: 711-6. PMID 15139851 DOI: 10.1042/Bj20040355  0.813
2004 Wang Y, Serfass L, Roy MO, Wong J, Bonneau AM, Georges E. Annexin-I expression modulates drug resistance in tumor cells. Biochemical and Biophysical Research Communications. 314: 565-70. PMID 14733945 DOI: 10.1016/J.Bbrc.2003.12.117  0.56
2004 Alqawi O, Poelarends G, Konings WN, Georges E. Erratum to: “Photoaffinity labeling under non-energized conditions of a specific drug-binding site of the ABC multidrug transporter LmrA from Lactococcus lactis” [Biochem. Biophys. Res. Commun. 311 (2003) 696–701] Biochemical and Biophysical Research Communications. 320: 286. DOI: 10.1016/J.Bbrc.2004.05.146  0.812
2003 Alqawi O, Poelarends G, Konings WN, Georges E, Alqwai O. Photoaffinity labeling under non-energized conditions of a specific drug-binding site of the ABC multidrug transporter LmrA from Lactococcus lactis. Biochemical and Biophysical Research Communications. 311: 696-701. PMID 14623328 DOI: 10.1016/J.Bbrc.2003.10.049  0.843
2003 Karwatsky J, Lincoln MC, Georges E. A mechanism for P-glycoprotein-mediated apoptosis as revealed by verapamil hypersensitivity. Biochemistry. 42: 12163-73. PMID 14567677 DOI: 10.1021/Bi034149+  0.488
2003 Gauthier C, Weber S, Alarco AM, Alqawi O, Daoud R, Georges E, Raymond M. Functional similarities and differences between Candida albicans Cdr1p and Cdr2p transporters. Antimicrobial Agents and Chemotherapy. 47: 1543-54. PMID 12709320 DOI: 10.1128/Aac.47.5.1543-1554.2003  0.776
2003 Alqawi O, Georges E. The multidrug resistance protein ABCC1 drug-binding domains show selective sensitivity to mild detergents. Biochemical and Biophysical Research Communications. 303: 1135-41. PMID 12684054 DOI: 10.1016/S0006-291X(03)00492-3  0.829
2003 Karwatsky J, Daoud R, Cai J, Gros P, Georges E. Binding of a photoaffinity analogue of glutathione to MRP1 (ABCC1) within two cytoplasmic regions (L0 and L1) as well as transmembrane domains 10-11 and 16-17. Biochemistry. 42: 3286-94. PMID 12641460 DOI: 10.1021/Bi0268807  0.805
2002 Cai J, Daoud R, Alqawi O, Georges E, Pelletier J, Gros P. Nucleotide binding and nucleotide hydrolysis properties of the ABC transporter MRP6 (ABCC6). Biochemistry. 41: 8058-67. PMID 12069597 DOI: 10.1021/Bi012082P  0.75
2001 Cai J, Daoud R, Georges E, Gros P. Functional expression of multidrug resistance protein 1 in Pichia pastoris. Biochemistry. 40: 8307-16. PMID 11444977 DOI: 10.1021/Bi010093C  0.812
2001 Daoud R, Julien M, Gros P, Georges E. Major photoaffinity drug binding sites in multidrug resistance protein 1 (MRP1) are within transmembrane domains 10-11 and 16-17. The Journal of Biological Chemistry. 276: 12324-30. PMID 11152467 DOI: 10.1074/Jbc.M009782200  0.819
2000 Daoud R, Kast C, Gros P, Georges E. Rhodamine 123 binds to multiple sites in the multidrug resistance protein (MRP1). Biochemistry. 39: 15344-52. PMID 11112520 DOI: 10.1021/Bi0020574  0.826
2000 Daoud R, Desneves J, Deady LW, Tilley L, Scheper RJ, Gros P, Georges E. The multidrug resistance protein is photoaffinity labeled by a quinoline-based drug at multiple sites. Biochemistry. 39: 6094-102. PMID 10821682 DOI: 10.1021/Bi9922188  0.833
2000 Vezmar M, Georges E. Reversal of MRP-mediated doxorubicin resistance with quinoline-based drugs. Biochemical Pharmacology. 59: 1245-52. PMID 10736425 DOI: 10.1016/S0006-2952(00)00270-7  0.566
2000 Abrahem A, Certad G, Pan X, Georges E. Pleiotropic resistance to diverse antimalarials in actinomycin D-resistant Plasmodium falciparum. Biochemical Pharmacology. 59: 1123-32. PMID 10704942 DOI: 10.1016/S0006-2952(00)00241-0  0.418
1999 Certad G, Abrahem A, Georges E. Cloning and partial characterization of the proteasome S4 ATPase from Plasmodium falciparum. Experimental Parasitology. 93: 123-31. PMID 10529354 DOI: 10.1006/Expr.1999.4442  0.424
1998 Vezmar M, Georges E. Direct binding of chloroquine to the multidrug resistance protein (MRP): possible role for MRP in chloroquine drug transport and resistance in tumor cells. Biochemical Pharmacology. 56: 733-42. PMID 9751078 DOI: 10.1016/S0006-2952(98)00217-2  0.625
1997 Vezmar M, Deady LW, Tilley L, Georges E. The quinoline-based drug, N-[4-[1-hydroxy-2-(dibutylamino)ethyl] quinolin-8-yl]-4-azidosalicylamide, photoaffinity labels the multidrug resistance protein (MRP) at a biologically relevant site. Biochemical and Biophysical Research Communications. 241: 104-11. PMID 9405241 DOI: 10.1006/Bbrc.1997.7634  0.61
1997 Wang Y, Pan XQ, Lheureux F, Georges E. Overexpression of a 40-kDa protein in human multidrug resistant cells. Biochemical and Biophysical Research Communications. 236: 483-8. PMID 9240465 DOI: 10.1006/Bbrc.1997.6991  0.544
1997 Pouliot JF, L'Heureux F, Liu Z, Prichard RK, Georges E. Reversal of P-glycoprotein-associated multidrug resistance by ivermectin. Biochemical Pharmacology. 53: 17-25. PMID 8960059 DOI: 10.1016/S0006-2952(96)00656-9  0.598
1996 Panasci L, Jean-Claude BJ, Vasilescu D, Mustafa A, Damian S, Damian Z, Georges E, Liu Z, Batist G, Leyland-Jones B. Sensitization to doxorubicin resistance in breast cancer cell lines by tamoxifen and megestrol acetate. Biochemical Pharmacology. 52: 1097-102. PMID 8831729 DOI: 10.1016/0006-2952(96)00456-X  0.418
1996 Nare B, Lubega G, Prichard RK, Georges E. p-Azidosalicyl-5-amino-6-phenoxybenzimidazole photolabels the N-terminal 63-103 amino acids of Haemonchus contortus beta-tubulin 1. The Journal of Biological Chemistry. 271: 8575-81. PMID 8621485 DOI: 10.1074/Jbc.271.15.8575  0.452
1994 Nare B, Liu Z, Prichard RK, Georges E. Benzimidazoles, potent anti-mitotic drugs: substrates for the P-glycoprotein transporter in multidrug-resistant cells. Biochemical Pharmacology. 48: 2215-22. PMID 7811303 DOI: 10.1016/0006-2952(94)00427-7  0.581
1991 Georges E, Zhang JT, Ling V. Modulation of ATP and drug binding by monoclonal antibodies against P-glycoprotein. Journal of Cellular Physiology. 148: 479-84. PMID 1680871 DOI: 10.1002/Jcp.1041480321  0.59
1990 Georges E, Sharom FJ, Ling V. Multidrug resistance and chemosensitization: therapeutic implications for cancer chemotherapy. Advances in Pharmacology (San Diego, Calif.). 21: 185-220. PMID 2265126 DOI: 10.1016/S1054-3589(08)60343-9  0.443
1989 Georges E, Lindenbaum MH, Sacher MG, Trifaró JM, Mushynski WE. Neurofilament phosphorylation in cultured bovine adrenal chromaffin cells is stimulated by phorbol ester. Journal of Neurochemistry. 52: 1156-61. PMID 2926395 DOI: 10.1111/J.1471-4159.1989.Tb01861.X  0.359
1988 Greenberger LM, Williams SS, Georges E, Ling V, Horwitz SB. Electrophoretic analysis of P-glycoproteins produced by mouse J774.2 and Chinese hamster ovary multidrug-resistant cells. Journal of the National Cancer Institute. 80: 506-10. PMID 2896800 DOI: 10.1093/Jnci/80.7.506  0.446
1987 Georges E, Mushynski WE. Chemical modification of charged amino acid moieties alters the electrophoretic mobilities of neurofilament subunits on SDS/polyacrylamide gels. European Journal of Biochemistry / Febs. 165: 281-7. PMID 3595591 DOI: 10.1111/J.1432-1033.1987.Tb11439.X  0.345
1984 Bader MF, Georges E, Mushynski WE, Trifaró JM. Neurofilament proteins in cultured chromaffin cells. Journal of Neurochemistry. 43: 1180-93. PMID 6432962 DOI: 10.1111/J.1471-4159.1984.Tb12859.X  0.337
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