| Year |
Citation |
Score |
| 2023 |
Watkins JL, Li Q, Yeaman S, Facchini PJ. Elucidation of the mescaline biosynthetic pathway in peyote (Lophophora williamsii). The Plant Journal : For Cell and Molecular Biology. PMID 37675639 DOI: 10.1111/tpj.16447 |
0.383 |
|
| 2023 |
Menéndez-Perdomo IM, Facchini PJ. Elucidation of the (R)-enantiospecific benzylisoquinoline alkaloid biosynthetic pathways in sacred lotus (Nelumbo nucifera). Scientific Reports. 13: 2955. PMID 36805479 DOI: 10.1038/s41598-023-29415-0 |
0.318 |
|
| 2022 |
Ozber N, Facchini PJ. Phloem-specific localization of benzylisoquinoline alkaloid metabolism in opium poppy. Journal of Plant Physiology. 271: 153641. PMID 35240512 DOI: 10.1016/j.jplph.2022.153641 |
0.335 |
|
| 2022 |
Watkins JL, Facchini PJ. Compartmentalization at the interface of primary and alkaloid metabolism. Current Opinion in Plant Biology. 66: 102186. PMID 35219143 DOI: 10.1016/j.pbi.2022.102186 |
0.317 |
|
| 2020 |
Ozber N, Watkins JL, Facchini PJ. Back to the plant: overcoming roadblocks to the microbial production of pharmaceutically important plant natural products. Journal of Industrial Microbiology & Biotechnology. PMID 32772209 DOI: 10.1007/S10295-020-02300-9 |
0.434 |
|
| 2020 |
Morris JS, Caldo KM, Liang S, Facchini P. PR10/Bet v 1-like proteins as novel contributors to plant biochemical diversity. Chembiochem : a European Journal of Chemical Biology. PMID 32700448 DOI: 10.1002/Cbic.202000354 |
0.373 |
|
| 2020 |
Chen R, Chen X, Hagel JM, Facchini PJ. Virus-Induced Gene Silencing to Investigate Alkaloid Biosynthesis in Opium Poppy. Methods in Molecular Biology (Clifton, N.J.). 2172: 75-92. PMID 32557363 DOI: 10.1007/978-1-0716-0751-0_7 |
0.399 |
|
| 2020 |
Li Q, Ramasamy S, Singh P, Hagel JM, Dunemann SM, Chen X, Chen R, Yu L, Tucker JE, Facchini PJ, Yeaman S. Author Correction: Gene clustering and copy number variation in alkaloid metabolic pathways of opium poppy. Nature Communications. 11: 2899. PMID 32499609 DOI: 10.1038/S41467-020-16467-3 |
0.321 |
|
| 2020 |
Li Q, Ramasamy S, Singh P, Hagel JM, Dunemann SM, Chen X, Chen R, Yu L, Tucker JE, Facchini PJ, Yeaman S. Gene clustering and copy number variation in alkaloid metabolic pathways of opium poppy. Nature Communications. 11: 1190. PMID 32132540 DOI: 10.1038/S41467-020-15040-2 |
0.36 |
|
| 2019 |
Menéndez-Perdomo IM, Facchini PJ. Isolation and characterization of two -methyltransferases involved in benzylisoquinoline alkaloids biosynthesis in sacred lotus (). The Journal of Biological Chemistry. PMID 31914404 DOI: 10.1074/Jbc.Ra119.011547 |
0.529 |
|
| 2019 |
Morris JS, Yu L, Facchini PJ. A single residue determines substrate preference in benzylisoquinoline alkaloid N-methyltransferases. Phytochemistry. 170: 112193. PMID 31765874 DOI: 10.1016/J.Phytochem.2019.112193 |
0.484 |
|
| 2019 |
Facchini PJ, Morris JS. Molecular Origins of Functional Diversity in Benzylisoquinoline Alkaloid Methyltransferases. Frontiers in Plant Science. 10: 1058. PMID 31543888 DOI: 10.3389/Fpls.2019.01058 |
0.444 |
|
| 2019 |
Dastmalchi M, Chang L, Chen R, Yu L, Chen X, Hagel J, Facchini PJ. Purine permease-type benzylisoquinoline alkaloid transporters in opium poppy. Plant Physiology. PMID 31467164 DOI: 10.1104/Pp.19.00565 |
0.385 |
|
| 2019 |
Lang DE, Morris JS, Rowley M, Torres MA, Maksimovich VA, Facchini PJ, Ng KKS. Structure-function studies of tetrahydroprotoberberine -methyltransferase reveal the molecular basis of stereoselective substrate recognition. The Journal of Biological Chemistry. PMID 31395658 DOI: 10.1074/Jbc.Ra119.009214 |
0.387 |
|
| 2019 |
Dastmalchi M, Chen X, Hagel JM, Chang L, Chen R, Ramasamy S, Yeaman S, Facchini PJ. Neopinone isomerase is involved in codeine and morphine biosynthesis in opium poppy. Nature Chemical Biology. PMID 30886433 DOI: 10.1038/S41589-019-0247-0 |
0.409 |
|
| 2019 |
Hagel JM, Facchini PJ. Expanding the roles for 2-oxoglutarate-dependent oxygenases in plant metabolism. Natural Product Reports. 35: 721-734. PMID 29488530 DOI: 10.1039/c7np00060j |
0.392 |
|
| 2019 |
Facchini PJ, De Luca V. Phloem-Specific Expression of Tyrosine/Dopa Decarboxylase Genes and the Biosynthesis of Isoquinoline Alkaloids in Opium Poppy. The Plant Cell. 7: 1811-1821. PMID 12242361 DOI: 10.1105/Tpc.7.11.1811 |
0.395 |
|
| 2019 |
Singh A, Menéndez-Perdomo IM, Facchini PJ. Benzylisoquinoline alkaloid biosynthesis in opium poppy: an update Phytochemistry Reviews. 18: 1457-1482. DOI: 10.1007/S11101-019-09644-W |
0.451 |
|
| 2018 |
Menéndez-Perdomo IM, Facchini PJ. Benzylisoquinoline Alkaloids Biosynthesis in Sacred Lotus. Molecules (Basel, Switzerland). 23. PMID 30404216 DOI: 10.3390/Molecules23112899 |
0.466 |
|
| 2018 |
Hagel JM, Chen X, Facchini PJ. Production of methylparaben in Escherichia coli. Journal of Industrial Microbiology & Biotechnology. PMID 30392093 DOI: 10.1007/S10295-018-2102-9 |
0.43 |
|
| 2018 |
Morris JS, Groves RA, Hagel JM, Facchini PJ. An -methyltransferase from catalyzing the formation of ephedrine and pseudoephedrine enables microbial phenylalkylamine production. The Journal of Biological Chemistry. PMID 29929980 DOI: 10.1074/Jbc.Ra118.004067 |
0.536 |
|
| 2018 |
Chen X, Hagel JM, Chang L, Tucker JE, Shiigi SA, Yelpaala Y, Chen HY, Estrada R, Colbeck J, Enquist-Newman M, Ibáñez AB, Cottarel G, Vidanes GM, Facchini PJ. A pathogenesis-related 10 protein catalyzes the final step in thebaine biosynthesis. Nature Chemical Biology. PMID 29807982 DOI: 10.1038/S41589-018-0059-7 |
0.434 |
|
| 2018 |
Dastmalchi M, Chang L, Torres MA, Ng KKS, Facchini PJ. Codeinone reductase isoforms with differential stability, efficiency and product selectivity in opium poppy. The Plant Journal : For Cell and Molecular Biology. PMID 29779229 DOI: 10.1111/Tpj.13975 |
0.43 |
|
| 2018 |
Park MR, Chen X, Lang DE, Ng KKS, Facchini PJ. Heterodimeric O-methyltransferases involved in the biosynthesis of noscapine in opium poppy. The Plant Journal : For Cell and Molecular Biology. PMID 29723437 DOI: 10.1111/Tpj.13947 |
0.415 |
|
| 2018 |
Lang DE, Lancaster JM, Torres MA, Morris JS, Facchini PJ, Ng KKS. Substrate specificity of N-methyltransferases in benzylisoquinoline alkaloid metabolism Acta Crystallographica Section a Foundations and Advances. 74: a272-a272. DOI: 10.1107/S0108767318097271 |
0.367 |
|
| 2017 |
Hagel JM, Facchini PJ. Tying the knot: occurrence and possible significance of gene fusions in plant metabolism and beyond. Journal of Experimental Botany. PMID 28521055 DOI: 10.1093/Jxb/Erx152 |
0.483 |
|
| 2017 |
Dastmalchi M, Park MR, Morris JS, Facchini P. Family portraits: the enzymes behind benzylisoquinoline alkaloid diversity Phytochemistry Reviews. 17: 249-277. DOI: 10.1007/S11101-017-9519-Z |
0.476 |
|
| 2016 |
Li J, Lee EJ, Chang L, Facchini PJ. Genes encoding norcoclaurine synthase occur as tandem fusions in the Papaveraceae. Scientific Reports. 6: 39256. PMID 27991536 DOI: 10.1038/Srep39256 |
0.405 |
|
| 2016 |
Dastmalchi M, Facchini PJ. Plant metabolons assembled on demand. Science (New York, N.Y.). 354: 829-830. PMID 27856864 DOI: 10.1126/Science.Aal2948 |
0.415 |
|
| 2016 |
Morris JS, Facchini PJ. Isolation and Characterization of Reticuline N-Methyltransferase Involved in Biosynthesis of the Aporphine Alkaloid Magnoflorine in Opium Poppy. The Journal of Biological Chemistry. PMID 27634038 DOI: 10.1074/Jbc.M116.750893 |
0.53 |
|
| 2016 |
Torres MA, Hoffarth E, Eugenio L, Savtchouk J, Chen X, Morris J, Facchini PJ, Ng KK. Structural and Functional Studies of Pavine N-Methyltransferase from Thalictrum flavum Reveal Novel Insights into Substrate Recognition and Catalytic Mechanism. The Journal of Biological Chemistry. PMID 27573242 DOI: 10.1074/Jbc.M116.747261 |
0.436 |
|
| 2016 |
Morris JS, Dastmalchi M, Li J, Chang L, Chen X, Hagel JM, Facchini PJ. Plug-and-Play Benzylisoquinoline Alkaloid Biosynthetic Gene Discovery in Engineered Yeast. Methods in Enzymology. 575: 143-78. PMID 27417928 DOI: 10.1016/Bs.Mie.2016.03.023 |
0.494 |
|
| 2016 |
Kilpatrick K, Pajak A, Hagel JM, Sumarah MW, Lewinsohn E, Facchini PJ, Marsolais F. Characterization of aromatic aminotransferases from Ephedra sinica Stapf. Amino Acids. PMID 26832171 DOI: 10.1007/S00726-015-2156-1 |
0.451 |
|
| 2016 |
Morris JS, Dastmalchi M, Li J, Chang L, Chen X, Hagel JM, Facchini PJ. Plug-and-Play Benzylisoquinoline Alkaloid Biosynthetic Gene Discovery in Engineered Yeast Methods in Enzymology. DOI: 10.1016/bs.mie.2016.03.023 |
0.397 |
|
| 2015 |
Hagel JM, Morris JS, Lee EJ, Desgagné-Penix I, Bross CD, Chang L, Chen X, Farrow SC, Zhang Y, Soh J, Sensen CW, Facchini PJ. Transcriptome analysis of 20 taxonomically related benzylisoquinoline alkaloid-producing plants. Bmc Plant Biology. 15: 227. PMID 26384972 DOI: 10.1186/S12870-015-0596-0 |
0.484 |
|
| 2015 |
Hagel JM, Mandal R, Han B, Han J, Dinsmore DR, Borchers CH, Wishart DS, Facchini PJ. Metabolome analysis of 20 taxonomically related benzylisoquinoline alkaloid-producing plants. Bmc Plant Biology. 15: 220. PMID 26369413 DOI: 10.1186/S12870-015-0594-2 |
0.474 |
|
| 2015 |
Chang L, Hagel JM, Facchini PJ. Isolation and Characterization of O-methyltransferases Involved in the Biosynthesis of Glaucine in Glaucium flavum. Plant Physiology. 169: 1127-40. PMID 26297140 DOI: 10.1104/Pp.15.01240 |
0.356 |
|
| 2015 |
Farrow SC, Facchini PJ. Papaverine 7-O-demethylase, a novel 2-oxoglutarate/Fe(2+)-dependent dioxygenase from opium poppy. Febs Letters. 589: 2701-6. PMID 26264169 DOI: 10.1016/J.Febslet.2015.07.042 |
0.319 |
|
| 2015 |
Farrow SC, Hagel JM, Beaudoin GA, Burns DC, Facchini PJ. Stereochemical inversion of (S)-reticuline by a cytochrome P450 fusion in opium poppy. Nature Chemical Biology. 11: 728-32. PMID 26147354 DOI: 10.1038/Nchembio.1879 |
0.439 |
|
| 2015 |
Groves RA, Hagel JM, Zhang Y, Kilpatrick K, Levy A, Marsolais F, Lewinsohn E, Sensen CW, Facchini PJ. Transcriptome profiling of khat (Catha edulis) and Ephedra sinica reveals gene candidates potentially involved in amphetamine-type alkaloid biosynthesis. Plos One. 10: e0119701. PMID 25806807 DOI: 10.1371/Journal.Pone.0119701 |
0.511 |
|
| 2015 |
Chen X, Dang TT, Facchini PJ. Noscapine comes of age. Phytochemistry. 111: 7-13. PMID 25583437 DOI: 10.1016/J.Phytochem.2014.09.008 |
0.754 |
|
| 2015 |
Dang TT, Chen X, Facchini PJ. Acetylation serves as a protective group in noscapine biosynthesis in opium poppy. Nature Chemical Biology. 11: 104-6. PMID 25485687 DOI: 10.1038/Nchembio.1717 |
0.704 |
|
| 2014 |
Farrow SC, Facchini PJ. Functional diversity of 2-oxoglutarate/Fe(II)-dependent dioxygenases in plant metabolism. Frontiers in Plant Science. 5: 524. PMID 25346740 DOI: 10.3389/Fpls.2014.00524 |
0.419 |
|
| 2014 |
Chen X, Facchini PJ. Short-chain dehydrogenase/reductase catalyzing the final step of noscapine biosynthesis is localized to laticifers in opium poppy. The Plant Journal : For Cell and Molecular Biology. 77: 173-84. PMID 24708518 DOI: 10.1111/Tpj.12379 |
0.502 |
|
| 2014 |
Beaudoin GA, Facchini PJ. Benzylisoquinoline alkaloid biosynthesis in opium poppy. Planta. 240: 19-32. PMID 24671624 DOI: 10.1007/S00425-014-2056-8 |
0.493 |
|
| 2014 |
Fossati E, Ekins A, Narcross L, Zhu Y, Falgueyret JP, Beaudoin GA, Facchini PJ, Martin VJ. Reconstitution of a 10-gene pathway for synthesis of the plant alkaloid dihydrosanguinarine in Saccharomyces cerevisiae. Nature Communications. 5: 3283. PMID 24513861 DOI: 10.1038/Ncomms4283 |
0.475 |
|
| 2014 |
Dang TT, Facchini PJ. CYP82Y1 is N-methylcanadine 1-hydroxylase, a key noscapine biosynthetic enzyme in opium poppy. The Journal of Biological Chemistry. 289: 2013-26. PMID 24324259 DOI: 10.1074/Jbc.M113.505099 |
0.748 |
|
| 2014 |
Dang TT, Facchini PJ. Cloning and characterization of canadine synthase involved in noscapine biosynthesis in opium poppy. Febs Letters. 588: 198-204. PMID 24316226 DOI: 10.1016/J.Febslet.2013.11.037 |
0.742 |
|
| 2013 |
Onoyovwe A, Hagel JM, Chen X, Khan MF, Schriemer DC, Facchini PJ. Morphine biosynthesis in opium poppy involves two cell types: sieve elements and laticifers. The Plant Cell. 25: 4110-22. PMID 24104569 DOI: 10.1105/Tpc.113.115113 |
0.378 |
|
| 2013 |
Farrow SC, Facchini PJ. Dioxygenases catalyze O-demethylation and O,O-demethylenation with widespread roles in benzylisoquinoline alkaloid metabolism in opium poppy. The Journal of Biological Chemistry. 288: 28997-9012. PMID 23928311 DOI: 10.1074/Jbc.M113.488585 |
0.361 |
|
| 2013 |
Lee EJ, Hagel JM, Facchini PJ. Role of the phloem in the biochemistry and ecophysiology of benzylisoquinoline alkaloid metabolism. Frontiers in Plant Science. 4: 182. PMID 23781223 DOI: 10.3389/Fpls.2013.00182 |
0.472 |
|
| 2013 |
Xiao M, Zhang Y, Chen X, Lee EJ, Barber CJ, Chakrabarty R, Desgagné-Penix I, Haslam TM, Kim YB, Liu E, MacNevin G, Masada-Atsumi S, Reed DW, Stout JM, Zerbe P, ... ... Facchini PJ, et al. Transcriptome analysis based on next-generation sequencing of non-model plants producing specialized metabolites of biotechnological interest. Journal of Biotechnology. 166: 122-34. PMID 23602801 DOI: 10.1016/J.Jbiotec.2013.04.004 |
0.436 |
|
| 2013 |
Hagel JM, Facchini PJ. Benzylisoquinoline alkaloid metabolism: a century of discovery and a brave new world. Plant & Cell Physiology. 54: 647-72. PMID 23385146 DOI: 10.1093/Pcp/Pct020 |
0.532 |
|
| 2013 |
Beaudoin GA, Facchini PJ. Isolation and characterization of a cDNA encoding (S)-cis-N-methylstylopine 14-hydroxylase from opium poppy, a key enzyme in sanguinarine biosynthesis. Biochemical and Biophysical Research Communications. 431: 597-603. PMID 23313486 DOI: 10.1016/J.Bbrc.2012.12.129 |
0.467 |
|
| 2012 |
Hagel JM, Beaudoin GA, Fossati E, Ekins A, Martin VJ, Facchini PJ. Characterization of a flavoprotein oxidase from opium poppy catalyzing the final steps in sanguinarine and papaverine biosynthesis. The Journal of Biological Chemistry. 287: 42972-83. PMID 23118227 DOI: 10.1074/Jbc.M112.420414 |
0.466 |
|
| 2012 |
Dang TT, Onoyovwi A, Farrow SC, Facchini PJ. Biochemical genomics for gene discovery in benzylisoquinoline alkaloid biosynthesis in opium poppy and related species. Methods in Enzymology. 515: 231-66. PMID 22999177 DOI: 10.1016/B978-0-12-394290-6.00011-2 |
0.756 |
|
| 2012 |
Krizevski R, Bar E, Shalit OR, Levy A, Hagel JM, Kilpatrick K, Marsolais F, Facchini PJ, Ben-Shabat S, Sitrit Y, Lewinsohn E. Benzaldehyde is a precursor of phenylpropylamino alkaloids as revealed by targeted metabolic profiling and comparative biochemical analyses in Ephedra spp. Phytochemistry. 81: 71-9. PMID 22727117 DOI: 10.1016/J.Phytochem.2012.05.018 |
0.307 |
|
| 2012 |
Desgagné-Penix I, Facchini PJ. Systematic silencing of benzylisoquinoline alkaloid biosynthetic genes reveals the major route to papaverine in opium poppy. The Plant Journal : For Cell and Molecular Biology. 72: 331-44. PMID 22725256 DOI: 10.1111/J.1365-313X.2012.05084.X |
0.424 |
|
| 2012 |
Dang TT, Facchini PJ. Characterization of three O-methyltransferases involved in noscapine biosynthesis in opium poppy. Plant Physiology. 159: 618-31. PMID 22535422 DOI: 10.1104/Pp.112.194886 |
0.739 |
|
| 2012 |
Desgagné-Penix I, Farrow SC, Cram D, Nowak J, Facchini PJ. Integration of deep transcript and targeted metabolite profiles for eight cultivars of opium poppy. Plant Molecular Biology. 79: 295-313. PMID 22527754 DOI: 10.1007/S11103-012-9913-2 |
0.463 |
|
| 2012 |
Hagel JM, Krizevski R, Marsolais F, Lewinsohn E, Facchini PJ. Biosynthesis of amphetamine analogs in plants. Trends in Plant Science. 17: 404-12. PMID 22502775 DOI: 10.1016/J.Tplants.2012.03.004 |
0.473 |
|
| 2012 |
Farrow SC, Hagel JM, Facchini PJ. Transcript and metabolite profiling in cell cultures of 18 plant species that produce benzylisoquinoline alkaloids. Phytochemistry. 77: 79-88. PMID 22424601 DOI: 10.1016/J.Phytochem.2012.02.014 |
0.499 |
|
| 2012 |
Facchini PJ, Bohlmann J, Covello PS, De Luca V, Mahadevan R, Page JE, Ro DK, Sensen CW, Storms R, Martin VJ. Synthetic biosystems for the production of high-value plant metabolites. Trends in Biotechnology. 30: 127-31. PMID 22209518 DOI: 10.1016/J.Tibtech.2011.10.001 |
0.487 |
|
| 2012 |
Wijekoon CP, Facchini PJ. Systematic knockdown of morphine pathway enzymes in opium poppy using virus-induced gene silencing. The Plant Journal : For Cell and Molecular Biology. 69: 1052-63. PMID 22098111 DOI: 10.1111/J.1365-313X.2011.04855.X |
0.465 |
|
| 2012 |
Hagel JM, Facchini PJ. Subcellular localization of sanguinarine biosynthetic enzymes in cultured opium poppy cells In Vitro Cellular & Developmental Biology - Plant. 48: 233-240. DOI: 10.1007/S11627-012-9426-3 |
0.435 |
|
| 2011 |
Hagel JM, Krizevski R, Kilpatrick K, Sitrit Y, Marsolais F, Lewinsohn E, Facchini PJ. Expressed sequence tag analysis of khat (Catha edulis) provides a putative molecular biochemical basis for the biosynthesis of phenylpropylamino alkaloids. Genetics and Molecular Biology. 34: 640-6. PMID 22215969 DOI: 10.1590/S1415-47572011000400017 |
0.4 |
|
| 2011 |
Lee EJ, Facchini PJ. Tyrosine aminotransferase contributes to benzylisoquinoline alkaloid biosynthesis in opium poppy. Plant Physiology. 157: 1067-78. PMID 21949209 DOI: 10.1104/Pp.111.185512 |
0.478 |
|
| 2010 |
Hagel JM, Facchini PJ. Biochemistry and occurrence of o-demethylation in plant metabolism. Frontiers in Physiology. 1: 14. PMID 21423357 DOI: 10.3389/Fphys.2010.00014 |
0.453 |
|
| 2010 |
Desgagné-Penix I, Khan MF, Schriemer DC, Cram D, Nowak J, Facchini PJ. Integration of deep transcriptome and proteome analyses reveals the components of alkaloid metabolism in opium poppy cell cultures. Bmc Plant Biology. 10: 252. PMID 21083930 DOI: 10.1186/1471-2229-10-252 |
0.406 |
|
| 2010 |
Lee EJ, Facchini P. Norcoclaurine synthase is a member of the pathogenesis-related 10/Bet v1 protein family. The Plant Cell. 22: 3489-503. PMID 21037103 DOI: 10.1105/Tpc.110.077958 |
0.405 |
|
| 2010 |
Hagel JM, Facchini PJ. Dioxygenases catalyze the O-demethylation steps of morphine biosynthesis in opium poppy. Nature Chemical Biology. 6: 273-5. PMID 20228795 DOI: 10.1038/Nchembio.317 |
0.411 |
|
| 2009 |
Ziegler J, Facchini PJ, Geissler R, Schmidt J, Ammer C, Kramell R, Voigtländer S, Gesell A, Pienkny S, Brandt W. Evolution of morphine biosynthesis in opium poppy. Phytochemistry. 70: 1696-707. PMID 19665152 DOI: 10.1016/J.Phytochem.2009.07.006 |
0.517 |
|
| 2009 |
Lee EJ, Rustem S, Weljie AM, Vogel HJ, Facchini PJ, Park SU, Kim YK, Yang TJ. Quality assessment of ginseng by1H NMR metabolite fingerprinting and profiling analysis Journal of Agricultural and Food Chemistry. 57: 7513-7522. PMID 19655726 DOI: 10.1021/Jf901675Y |
0.535 |
|
| 2009 |
Ziegler J, Brandt W, Geissler R, Facchini PJ. Removal of substrate inhibition and increase in maximal velocity in the short chain dehydrogenase/reductase salutaridine reductase involved in morphine biosynthesis. The Journal of Biological Chemistry. 284: 26758-67. PMID 19648114 DOI: 10.1074/Jbc.M109.030957 |
0.368 |
|
| 2009 |
Liscombe DK, Ziegler J, Schmidt J, Ammer C, Facchini PJ. Targeted metabolite and transcript profiling for elucidating enzyme function: isolation of novel N-methyltransferases from three benzylisoquinoline alkaloid-producing species. The Plant Journal : For Cell and Molecular Biology. 60: 729-43. PMID 19624470 DOI: 10.1111/J.1365-313X.2009.03980.X |
0.475 |
|
| 2009 |
Zulak KG, Khan MF, Alcantara J, Schriemer DC, Facchini PJ. Plant defense responses in opium poppy cell cultures revealed by liquid chromatography-tandem mass spectrometry proteomics. Molecular & Cellular Proteomics : McP. 8: 86-98. PMID 18682378 DOI: 10.1074/Mcp.M800211-Mcp200 |
0.453 |
|
| 2008 |
Jain A, Ziegler J, Liscombe DK, Facchini PJ, Tucker PA, Panjikar S. Purification, crystallization and X-ray diffraction analysis of pavine N-methyltransferase from Thalictrum flavum. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 64: 1066-9. PMID 18997344 DOI: 10.1107/S1744309108033046 |
0.38 |
|
| 2008 |
Hagel JM, Yeung EC, Facchini PJ. Got milk? The secret life of laticifers. Trends in Plant Science. 13: 631-9. PMID 18977166 DOI: 10.1016/J.Tplants.2008.09.005 |
0.421 |
|
| 2008 |
Hagel JM, Weljie AM, Vogel HJ, Facchini PJ. Quantitative 1H nuclear magnetic resonance metabolite profiling as a functional genomics platform to investigate alkaloid biosynthesis in opium poppy Plant Physiology. 147: 1805-1821. PMID 18550684 DOI: 10.1104/Pp.108.120493 |
0.464 |
|
| 2008 |
Facchini PJ, De Luca V. Opium poppy and Madagascar periwinkle: model non-model systems to investigate alkaloid biosynthesis in plants. The Plant Journal : For Cell and Molecular Biology. 54: 763-84. PMID 18476877 DOI: 10.1111/J.1365-313X.2008.03438.X |
0.493 |
|
| 2008 |
Liscombe DK, Facchini PJ. Evolutionary and cellular webs in benzylisoquinoline alkaloid biosynthesis. Current Opinion in Biotechnology. 19: 173-80. PMID 18396034 DOI: 10.1016/J.Copbio.2008.02.012 |
0.479 |
|
| 2008 |
Ziegler J, Facchini PJ. Alkaloid biosynthesis: metabolism and trafficking. Annual Review of Plant Biology. 59: 735-69. PMID 18251710 DOI: 10.1146/Annurev.Arplant.59.032607.092730 |
0.505 |
|
| 2008 |
Zulak KG, Weljie AM, Vogel HJ, Facchini PJ. Quantitative 1H NMR metabolomics reveals extensive metabolic reprogramming of primary and secondary metabolism in elicitor-treated opium poppy cell cultures. Bmc Plant Biology. 8: 5. PMID 18211706 DOI: 10.1186/1471-2229-8-5 |
0.428 |
|
| 2008 |
Facchini PJ, Loukanina N, Blanche V. Genetic transformation via somatic embryogenesis to establish herbicide-resistant opium poppy. Plant Cell Reports. 27: 719-27. PMID 18057938 DOI: 10.1007/S00299-007-0483-8 |
0.437 |
|
| 2007 |
Berkner H, Engelhorn J, Liscombe DK, Schweimer K, Wöhrl BM, Facchini PJ, Rösch P, Matecko I. High-yield expression and purification of isotopically labeled norcoclaurine synthase, a Bet v 1-homologous enzyme, from Thalictrum flavum for NMR studies. Protein Expression and Purification. 56: 197-204. PMID 17900926 DOI: 10.1016/J.Pep.2007.07.010 |
0.462 |
|
| 2007 |
Luk LYP, Bunn S, Liscombe DK, Facchini PJ, Tanner ME. Mechanistic studies on norcoclaurine synthase of benzylisoquinoline alkaloid biosynthesis: An enzymatic Pictet-Spengler reaction Biochemistry. 46: 10153-10161. PMID 17696451 DOI: 10.1021/Bi700752N |
0.348 |
|
| 2007 |
Liscombe DK, Facchini PJ. Molecular cloning and characterization of tetrahydroprotoberberine cis-N-methyltransferase, an enzyme involved in alkaloid biosynthesis in opium poppy. The Journal of Biological Chemistry. 282: 14741-51. PMID 17389594 DOI: 10.1074/Jbc.M611908200 |
0.511 |
|
| 2007 |
Zulak KG, Cornish A, Daskalchuk TE, Deyholos MK, Goodenowe DB, Gordon PM, Klassen D, Pelcher LE, Sensen CW, Facchini PJ. Gene transcript and metabolite profiling of elicitor-induced opium poppy cell cultures reveals the coordinate regulation of primary and secondary metabolism. Planta. 225: 1085-106. PMID 17077972 DOI: 10.1007/S00425-006-0419-5 |
0.474 |
|
| 2007 |
Berkner H, Schweimer K, Wöhrl BM, Facchini PJ, Vieths S, Rösch P, Matecko I. Structural characterization of norcoclaurine synthase suggests the enzyme to be a true member of the Bet v 1 protein family World Allergy Organization Journal. DOI: 10.1097/01.Wox.0000301404.71854.C1 |
0.308 |
|
| 2007 |
Hagel JM, Facchini PJ. Plant metabolomics: analytical platforms and integration with functional genomics Phytochemistry Reviews. 7: 479-497. DOI: 10.1007/S11101-007-9086-9 |
0.395 |
|
| 2007 |
Facchini PJ, Hagel JM, Liscombe DK, Loukanina N, MacLeod BP, Samanani N, Zulak KG. Opium poppy: Blueprint for an alkaloid factory Phytochemistry Reviews. 6: 97-124. DOI: 10.1007/S11101-006-9042-0 |
0.462 |
|
| 2006 |
Facchini PJ. Regulation of alkaloid biosynthesis in plants. The Alkaloids. Chemistry and Biology. 63: 1-44. PMID 17133713 DOI: 10.1016/S1099-4831(06)63001-0 |
0.485 |
|
| 2006 |
Samanani N, Alcantara J, Bourgault R, Zulak KG, Facchini PJ. The role of phloem sieve elements and laticifers in the biosynthesis and accumulation of alkaloids in opium poppy Plant Journal. 47: 547-563. PMID 16813579 DOI: 10.1111/J.1365-313X.2006.02801.X |
0.444 |
|
| 2006 |
MacLeod BP, Facchini PJ. Methods for regeneration and transformation in Eschscholzia californica: A model plant to investigate alkaloid biosynthesis. Methods in Molecular Biology (Clifton, N.J.). 318: 357-68. PMID 16673930 DOI: 10.1385/1-59259-959-1:357 |
0.425 |
|
| 2006 |
Samanani N, Facchini PJ. Chapter Three - Compartmentalization of Plant Secondary Metabolism Recent Advances in Phytochemistry. 40: 53-83. DOI: 10.1016/S0079-9920(06)80037-7 |
0.491 |
|
| 2005 |
Liscombe DK, MacLeod BP, Loukanina N, Nandi OI, Facchini PJ. Evidence for the monophyletic evolution of benzylisoquinoline alkaloid biosynthesis in angiosperms. Phytochemistry. 66: 2501-20. PMID 16342378 DOI: 10.1016/J.Phytochem.2005.04.044 |
0.48 |
|
| 2005 |
Facchini PJ, St-Pierre B. Synthesis and trafficking of alkaloid biosynthetic enzymes. Current Opinion in Plant Biology. 8: 657-66. PMID 16182601 DOI: 10.1016/J.Pbi.2005.09.008 |
0.44 |
|
| 2005 |
Liscombe DK, Macleod BP, Loukanina N, Nandi OI, Facchini PJ. Evidence for the monophyletic evolution of benzylisoquinoline alkaloid biosynthesis in angiosperms. Phytochemistry. 66: 1374-93. PMID 15925393 DOI: 10.1016/J.Phytochem.2005.04.029 |
0.478 |
|
| 2005 |
Alcantara J, Bird DA, Franceschi VR, Facchini PJ. Sanguinarine biosynthesis is associated with the endoplasmic reticulum in cultured opium poppy cells after elicitor treatment. Plant Physiology. 138: 173-83. PMID 15849302 DOI: 10.1104/Pp.105.059287 |
0.398 |
|
| 2005 |
Hagel JM, Facchini PJ. Elevated tyrosine decarboxylase and tyramine hydroxycinnamoyltransferase levels increase wound-induced tyramine-derived hydroxycinnamic acid amide accumulation in transgenic tobacco leaves. Planta. 221: 904-14. PMID 15744495 DOI: 10.1007/S00425-005-1484-X |
0.432 |
|
| 2005 |
Samanani N, Park SU, Facchini PJ. Cell type-specific localization of transcripts encoding nine consecutive enzymes involved in protoberberine alkaloid biosynthesis. The Plant Cell. 17: 915-26. PMID 15722473 DOI: 10.1105/Tpc.104.028654 |
0.634 |
|
| 2004 |
Samanani N, Liscombe DK, Facchini PJ. Molecular cloning and characterization of norcoclaurine synthase, an enzyme catalyzing the first committed step in benzylisoquinoline alkaloid biosynthesis. The Plant Journal : For Cell and Molecular Biology. 40: 302-13. PMID 15447655 DOI: 10.1111/J.1365-313X.2004.02210.X |
0.497 |
|
| 2004 |
Facchini PJ, Bird DA, St-Pierre B. Can Arabidopsis make complex alkaloids? Trends in Plant Science. 9: 116-22. PMID 15003234 DOI: 10.1016/J.Tplants.2004.01.004 |
0.485 |
|
| 2003 |
Bird DA, Franceschi VR, Facchini PJ. A tale of three cell types: alkaloid biosynthesis is localized to sieve elements in opium poppy. The Plant Cell. 15: 2626-35. PMID 14508000 DOI: 10.1105/Tpc.015396 |
0.46 |
|
| 2003 |
Facchini PJ, Park SU. Developmental and inducible accumulation of gene transcripts involved in alkaloid biosynthesis in opium poppy. Phytochemistry. 64: 177-86. PMID 12946416 DOI: 10.1016/S0031-9422(03)00292-9 |
0.651 |
|
| 2003 |
Park SU, Chae YA, Facchini PJ. Genetic transformation of the figwort, Scrophularia buergeriana Miq., an Oriental medicinal plant. Plant Cell Reports. 21: 1194-8. PMID 12910369 DOI: 10.1007/S00299-003-0639-0 |
0.628 |
|
| 2003 |
Park SU, Yu M, Facchini PJ. Modulation of berberine bridge enzyme levels in transgenic root cultures of California poppy alters the accumulation of benzophenanthridine alkaloids. Plant Molecular Biology. 51: 153-64. PMID 12602874 DOI: 10.1023/A:1021199311049 |
0.631 |
|
| 2003 |
Facchini PJ, Bird DA, MacLeod BP, Park SU, Samanani N. Chapter seven Multiple levels of control in the regulation of alkaloid biosynthesis Recent Advances in Phytochemistry. 37: 143-180. DOI: 10.1016/S0079-9920(03)80022-9 |
0.653 |
|
| 2002 |
Samanani N, Park SU, Facchini PJ. In vitro regeneration and genetic transformation of the berberine-producing plant, Thalictrum flavum ssp. glaucum. Physiologia Plantarum. 116: 79-86. PMID 12207665 DOI: 10.1034/J.1399-3054.2002.1160110.X |
0.57 |
|
| 2002 |
Samanani N, Facchini PJ. Purification and characterization of norcoclaurine synthase. The first committed enzyme in benzylisoquinoline alkaloid biosynthesis in plants. The Journal of Biological Chemistry. 277: 33878-83. PMID 12107162 DOI: 10.1074/Jbc.M203051200 |
0.413 |
|
| 2002 |
Park SU, Yu M, Facchini PJ. Antisense RNA-mediated suppression of benzophenanthridine alkaloid biosynthesis in transgenic cell cultures of California poppy. Plant Physiology. 128: 696-706. PMID 11842172 DOI: 10.1104/Pp.010741 |
0.605 |
|
| 2002 |
Samanani N, Facchini PJ. Isolation and partial characterization of norcoclaurine synthase, the first committed step in benzylisoquinoline alkaloid biosynthesis, from opium poppy. Planta. 213: 898-906. PMID 11722126 DOI: 10.1007/S004250100581 |
0.459 |
|
| 2002 |
Bird DA, Facchini PJ. Berberine bridge enzyme, a key branch-point enzyme in benzylisoquinoline alkaloid biosynthesis, contains a vacuolar sorting determinant. Planta. 213: 888-97. PMID 11722125 DOI: 10.1007/S004250100582 |
0.381 |
|
| 2002 |
Facchini PJ, Hagel J, Zulak KG. Hydroxycinnamic acid amide metabolism: physiology and biochemistry Canadian Journal of Botany. 80: 577-589. DOI: 10.1139/B02-065 |
0.482 |
|
| 2002 |
Samanani N, Yeung EC, Facchini PJ. Cell type-specific protoberberine alkaloid accumulation inThalictrum flavum Journal of Plant Physiology. 159: 1189-1196. DOI: 10.1078/0176-1617-00891 |
0.406 |
|
| 2001 |
Facchini PJ. ALKALOID BIOSYNTHESIS IN PLANTS: Biochemistry, Cell Biology, Molecular Regulation, and Metabolic Engineering Applications. Annual Review of Plant Physiology and Plant Molecular Biology. 52: 29-66. PMID 11337391 DOI: 10.1146/annurev.arplant.52.1.29 |
0.317 |
|
| 2001 |
Park S, Facchini PJ. Somatic embryogenesis from embryogenic cell suspension cultures of california poppy, Eschscholzia californica Cham In Vitro Cellular & Developmental Biology - Plant. 37: 35-39. DOI: 10.1007/S11627-001-0007-0 |
0.52 |
|
| 2000 |
Park SU, Facchini PJ. Agrobacterium-mediated genetic transformation of California poppy, Eschscholzia californica Cham., via somatic embryogenesis. Plant Cell Reports. 19: 1006-1012. PMID 30754831 DOI: 10.1007/S002990000213 |
0.412 |
|
| 2000 |
Park SU, Facchini PJ. High-efficiency somatic embryogenesis and plant regeneration in California poppy, Eschscholzia californica Cham. Plant Cell Reports. 19: 421-426. PMID 30754797 DOI: 10.1007/S002990050750 |
0.356 |
|
| 2000 |
Park SU, Facchini PJ. Agrobacterium rhizogenes-mediated transformation of opium poppy, Papaver somniferum l., and California poppy, Eschscholzia californica cham., root cultures. Journal of Experimental Botany. 51: 1005-16. PMID 10948228 DOI: 10.1093/Jexbot/51.347.1005 |
0.603 |
|
| 2000 |
Facchini PJ, Huber-Allanach KL, Tari LW. Plant aromatic L-amino acid decarboxylases: evolution, biochemistry, regulation, and metabolic engineering applications. Phytochemistry. 54: 121-38. PMID 10872203 DOI: 10.1016/S0031-9422(00)00050-9 |
0.443 |
|
| 2000 |
Yu M, Facchini PJ. Molecular cloning and characterization of a type III glutathione S
-transferase from cell suspension cultures of opium poppy treated with a fungal elicitor Physiologia Plantarum. 108: 101-109. DOI: 10.1034/J.1399-3054.2000.108001101.X |
0.481 |
|
| 2000 |
Park S, Facchini PJ. Agrobacterium-mediated transformation of opium poppy, Papaver somniferum, via shoot organogenesis Journal of Plant Physiology. 157: 207-214. DOI: 10.1016/S0176-1617(00)80192-3 |
0.556 |
|
| 1999 |
Facchini PJ. Plant secondary metabolism: out of the evolutionary abyss. Trends in Plant Science. 4: 382-384. PMID 10498958 DOI: 10.1016/S1360-1385(99)01476-4 |
0.426 |
|
| 1999 |
Yu M, Facchini PJ. Purification, characterization, and immunolocalization of hydroxycinnamoyl-CoA: tyramine N-(hydroxycinnamoyl)transferase from opium poppy. Planta. 209: 33-44. PMID 10467029 DOI: 10.1007/S004250050604 |
0.426 |
|
| 1999 |
Facchini PJ, Yu M, Penzes-Yost C. Decreased cell wall digestibility in canola transformed with chimeric tyrosine decarboxylase genes from opium poppy Plant Physiology. 120: 653-664. PMID 10398700 DOI: 10.1104/Pp.120.3.653 |
0.406 |
|
| 1999 |
Park SU, Johnson AG, Penzes-Yost C, Facchini PJ. Analysis of promoters from tyrosine/dihydroxyphenylalanine decarboxylase and berberine bridge enzyme genes involved in benzylisoquinoline alkaloid biosynthesis in opium poppy. Plant Molecular Biology. 40: 121-31. PMID 10394951 DOI: 10.1023/A:1026433112119 |
0.57 |
|
| 1998 |
Facchini PJ, Penzes-Yost C, Samanani N, Kowalchuk B. Expression patterns conferred by tyrosine/dihydroxyphenylalanine decarboxylase promoters from opium poppy are conserved in transgenic tobacco. Plant Physiology. 118: 69-81. PMID 9733527 DOI: 10.1104/Pp.118.1.69 |
0.416 |
|
| 1998 |
Facchini PJ. Temporal Correlation of Tyramine Metabolism with Alkaloid and Amide Biosynthesis in Elicited Opium Poppy Cell Cultures fn1 fn1Dedicated to Professor G. H. Neil Towers on the occasion of his seventy-fifth birthday. Phytochemistry. 49: 481-490. DOI: 10.1016/S0031-9422(98)00136-8 |
0.374 |
|
| 1998 |
Facchini PJ, Bird DA. Developmental regulation of benzylisoquinoline alkaloid biosynthesis in opium poppy plants and tissue cultures In Vitro Cellular & Developmental Biology - Plant. 34: 69-79. DOI: 10.1007/Bf02823126 |
0.461 |
|
| 1997 |
Facchini PJ, Penzes C, Johnson AG, Bull D. Molecular characterization of berberine bridge enzyme genes from opium poppy. Plant Physiology. 112: 1669-77. PMID 8972604 DOI: 10.1104/Pp.112.4.1669 |
0.49 |
|
| 1996 |
Facchini PJ, Johnson AG, Poupart J, de Luca V. Uncoupled defense gene expression and antimicrobial alkaloid accumulation in elicited opium poppy cell cultures. Plant Physiology. 111: 687-97. PMID 8754678 DOI: 10.1104/Pp.111.3.687 |
0.364 |
|
| 1995 |
Facchini PJ, De Luca V. Expression in Escherichia coli and partial characterization of two tyrosine/dopa decarboxylases from opium poppy. Phytochemistry. 38: 1119-26. PMID 7766394 DOI: 10.1016/0031-9422(94)00814-A |
0.351 |
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