| Year |
Citation |
Score |
| 2024 |
Erickson EC, You I, Perry G, Dugourd A, Donovan KA, Crafter C, Johannes JW, Williamson S, Moss JI, Ros S, Ziegler RE, Barry ST, Fischer ES, Gray NS, Madsen RR, ... Toker A, et al. Multiomic profiling of breast cancer cells uncovers stress MAPK-associated sensitivity to AKT degradation. Science Signaling. 17: eadf2670. PMID 38412255 DOI: 10.1126/scisignal.adf2670 |
0.513 |
|
| 2022 |
Dibble CC, Barritt SA, Perry GE, Lien EC, Geck RC, DuBois-Coyne SE, Bartee D, Zengeya TT, Cohen EB, Yuan M, Hopkins BD, Meier JL, Clohessy JG, Asara JM, Cantley LC, ... Toker A, et al. PI3K drives the de novo synthesis of coenzyme A from vitamin B5. Nature. PMID 35896750 DOI: 10.1038/s41586-022-04984-8 |
0.818 |
|
| 2021 |
Kishikawa T, Higuchi H, Wang L, Panch N, Maymi V, Best S, Lee S, Notoya G, Toker A, Matesic LE, Wulf GM, Wei W, Otsuka M, Koike K, Clohessy JG, et al. WWP1 inactivation enhances efficacy of PI3K inhibitors while suppressing their toxicities in breast cancer models. The Journal of Clinical Investigation. 131. PMID 34907909 DOI: 10.1172/JCI140436 |
0.45 |
|
| 2021 |
Madsen RR, Erickson EC, Rueda OM, Robin X, Caldas C, Toker A, Semple RK, Vanhaesebroeck B. Positive correlation between transcriptomic stemness and PI3K/AKT/mTOR signaling scores in breast cancer, and a counterintuitive relationship with PIK3CA genotype. Plos Genetics. 17: e1009876. PMID 34762647 DOI: 10.1371/journal.pgen.1009876 |
0.324 |
|
| 2020 |
Hillis AL, Toker A. Lactate Lights up PI3K Inhibitor Resistance in Breast Cancer. Cancer Cell. 38: 441-443. PMID 33049205 DOI: 10.1016/j.ccell.2020.09.011 |
0.31 |
|
| 2020 |
Cohen EB, Geck RC, Toker A. Metabolic pathway alterations in microvascular endothelial cells in response to hypoxia. Plos One. 15: e0232072. PMID 32645038 DOI: 10.1371/Journal.Pone.0232072 |
0.306 |
|
| 2020 |
Liu H, Paddock MN, Wang H, Murphy CJ, Geck RC, Navarro AJ, Wulf GM, Elemento O, Haucke V, Cantley LC, Toker A. The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple Negative Breast Cancer. Cancer Discovery. PMID 32513774 DOI: 10.1158/2159-8290.Cd-19-1262 |
0.559 |
|
| 2020 |
Geck RC, Foley JR, Murray Stewart T, Asara JM, Casero RA, Toker A. Inhibition of the polyamine synthesis enzyme ornithine decarboxylase sensitizes triple-negative breast cancer cells to cytotoxic chemotherapy. The Journal of Biological Chemistry. PMID 32139506 DOI: 10.1074/Jbc.Ra119.012376 |
0.423 |
|
| 2019 |
You I, Erickson EC, Donovan KA, Eleuteri NA, Fischer ES, Gray NS, Toker A. Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling. Cell Chemical Biology. PMID 31859249 DOI: 10.1016/J.Chembiol.2019.11.014 |
0.5 |
|
| 2019 |
Toker A. Double trouble for cancer gene. Science (New York, N.Y.). 366: 685-686. PMID 31699922 DOI: 10.1126/Science.Aaz4016 |
0.312 |
|
| 2019 |
Guo J, Dai X, Laurent B, Zheng N, Gan W, Zhang J, Guo A, Yuan M, Liu P, Asara JM, Toker A, Shi Y, Pandolfi PP, Wei W. AKT methylation by SETDB1 promotes AKT kinase activity and oncogenic functions. Nature Cell Biology. PMID 30692625 DOI: 10.1038/S41556-018-0261-6 |
0.503 |
|
| 2019 |
Toker A. Abstract ES6-2: PI3K in breast cancer, glutamine changes and methionine addiction Cancer Research. 79. DOI: 10.1158/1538-7445.Sabcs18-Es6-2 |
0.515 |
|
| 2018 |
Toker A, Dibble CC. PI 3-Kinase Signaling: AKTing up inside the Cell. Molecular Cell. 71: 875-876. PMID 30241602 DOI: 10.1016/J.Molcel.2018.09.006 |
0.794 |
|
| 2018 |
Clement E, Inuzuka H, Nihira NT, Wei W, Toker A. Skp2-dependent reactivation of AKT drives resistance to PI3K inhibitors. Science Signaling. 11. PMID 29535262 DOI: 10.1126/Scisignal.Aao3810 |
0.811 |
|
| 2017 |
Lien EC, Ghisolfi L, Geck RC, Asara JM, Toker A. Oncogenic PI3K promotes methionine dependency in breast cancer cells through the cystine-glutamate antiporter xCT. Science Signaling. 10. PMID 29259101 DOI: 10.1126/Scisignal.Aao6604 |
0.78 |
|
| 2017 |
Liu H, Murphy CJ, Karreth FA, Emdal KB, White FM, Elemento O, Toker A, Wulf GM, Cantley LC. Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple Negative Breast Cancer. Cancer Discovery. PMID 29203461 DOI: 10.1158/2159-8290.Cd-17-0679 |
0.541 |
|
| 2017 |
Manning BD, Toker A. AKT/PKB Signaling: Navigating the Network. Cell. 169: 381-405. PMID 28431241 DOI: 10.1016/J.Cell.2017.04.001 |
0.468 |
|
| 2017 |
Ruzzene M, Bertacchini J, Toker A, Marmiroli S. Cross-talk between the CK2 and AKT signaling pathways in cancer. Advances in Biological Regulation. PMID 28373060 DOI: 10.1016/J.Jbior.2017.03.002 |
0.508 |
|
| 2017 |
Lien EC, Dibble CC, Toker A. PI3K signaling in cancer: beyond AKT. Current Opinion in Cell Biology. 45: 62-71. PMID 28343126 DOI: 10.1016/J.Ceb.2017.02.007 |
0.839 |
|
| 2017 |
Brown KK, Spinelli JB, Asara JM, Toker A. Adaptive Reprogramming of De Novo Pyrimidine Synthesis Is a Metabolic Vulnerability in Triple-Negative Breast Cancer. Cancer Discovery. PMID 28255083 DOI: 10.1158/2159-8290.Cd-16-0611 |
0.403 |
|
| 2017 |
Thomas C, Henry W, Cuiffo BG, Collmann AY, Marangoni E, Benhamo V, Bhasin MK, Fan C, Fuhrmann L, Baldwin AS, Perou C, Vincent-Salomon A, Toker A, Karnoub AE. Pentraxin-3 is a PI3K signaling target that promotes stem cell-like traits in basal-like breast cancers. Science Signaling. 10. PMID 28223411 DOI: 10.1126/Scisignal.Aah4674 |
0.844 |
|
| 2017 |
Shimizu K, Fukushima H, Ogura K, Lien EC, Nihira NT, Zhang J, North BJ, Guo A, Nagashima K, Nakagawa T, Hoshikawa S, Watahiki A, Okabe K, Yamada A, Toker A, et al. The SCFβ-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis. Science Signaling. 10. PMID 28049764 DOI: 10.1126/Scisignal.Aah4117 |
0.71 |
|
| 2016 |
Henry WS, Laszewski T, Tsang T, Beca F, Beck AH, McAllister SS, Toker A. Aspirin suppresses growth in PI3K-mutant breast cancer by activating AMPK and inhibiting mTORC1 signaling. Cancer Research. PMID 27940576 DOI: 10.1158/0008-5472.Can-16-2400 |
0.837 |
|
| 2016 |
Henry WS, Hendrickson DG, Beca F, Glass B, Lindahl-Allen M, He L, Ji Z, Struhl K, Beck AH, Rinn JL, Toker A. LINC00520 is induced by Src, STAT3, and PI3K and plays a functional role in breast cancer. Oncotarget. PMID 27626181 DOI: 10.18632/Oncotarget.11962 |
0.812 |
|
| 2016 |
Guo J, Chakraborty AA, Liu P, Gan W, Zheng X, Inuzuka H, Wang B, Zhang J, Zhang L, Yuan M, Novak J, Cheng JQ, Toker A, Signoretti S, Zhang Q, et al. pVHL suppresses kinase activity of Akt in a proline-hydroxylation-dependent manner. Science (New York, N.Y.). 353: 929-32. PMID 27563096 DOI: 10.1126/Science.Aad5755 |
0.547 |
|
| 2016 |
Zhang J, Xu K, Liu P, Geng Y, Wang B, Gan W, Guo J, Wu F, Chin YR, Berrios C, Lien EC, Toker A, DeCaprio JA, Sicinski P, Wei W. Inhibition of Rb Phosphorylation Leads to mTORC2-Mediated Activation of Akt. Molecular Cell. PMID 27237051 DOI: 10.1016/J.Molcel.2016.04.023 |
0.796 |
|
| 2016 |
Lien EC, Lyssiotis CA, Juvekar A, Hu H, Asara JM, Cantley LC, Toker A. Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer. Nature Cell Biology. PMID 27088857 DOI: 10.1038/Ncb3341 |
0.828 |
|
| 2016 |
Mancini ML, Lien EC, Toker A. Oncogenic AKT1(E17K) mutation induces mammary hyperplasia but prevents HER2-driven tumorigenesis. Oncotarget. PMID 27004402 DOI: 10.18632/Oncotarget.8191 |
0.835 |
|
| 2016 |
Geck RC, Toker A. Nonessential amino acid metabolism in breast cancer. Advances in Biological Regulation. PMID 26838061 DOI: 10.1016/J.Jbior.2016.01.001 |
0.358 |
|
| 2015 |
Liu P, Gan W, Chin YR, Ogura K, Guo J, Zhang J, Wang B, Blenis J, Cantley LC, Toker A, Su B, Wei W. PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex. Cancer Discovery. 5: 1194-209. PMID 26293922 DOI: 10.1158/2159-8290.Cd-15-0460 |
0.581 |
|
| 2015 |
Toker A, Rameh L. PIPPing on AKT1: How Many Phosphatases Does It Take to Turn off PI3K? Cancer Cell. 28: 143-5. PMID 26267528 DOI: 10.1016/J.Ccell.2015.07.010 |
0.554 |
|
| 2015 |
Brown KK, Montaser-Kouhsari L, Beck AH, Toker A. MERIT40 Is an Akt Substrate that Promotes Resolution of DNA Damage Induced by Chemotherapy. Cell Reports. 11: 1358-66. PMID 26027929 DOI: 10.1016/J.Celrep.2015.05.004 |
0.477 |
|
| 2015 |
Brown KK, Toker A. The phosphoinositide 3-kinase pathway and therapy resistance in cancer. F1000prime Reports. 7: 13. PMID 25750731 DOI: 10.12703/P7-13 |
0.466 |
|
| 2015 |
Kaunisto A, Henry WS, Montaser-Kouhsari L, Jaminet SC, Oh EY, Zhao L, Luo HR, Beck AH, Toker A. NFAT1 promotes intratumoral neutrophil infiltration by regulating IL8 expression in breast cancer. Molecular Oncology. 9: 1140-54. PMID 25735562 DOI: 10.1016/J.Molonc.2015.02.004 |
0.797 |
|
| 2015 |
Toker A. Abstract IA06: PI 3-kinase and Akt at the interface of signaling and metabolism Molecular Cancer Therapeutics. 14. DOI: 10.1158/1538-8514.Pi3K14-Ia06 |
0.574 |
|
| 2015 |
Chin YR, Toker A. Abstract A42: Increased Akt3 expression as a resistance mechanism to targeted therapy Molecular Cancer Therapeutics. 14. DOI: 10.1158/1538-8514.Pi3K14-A42 |
0.474 |
|
| 2015 |
Henry W, Toker A. Abstract 2634: Investigating the chemotherapeutic effects of aspirin in mutant PIK3CA breast cancer Cancer Research. 75: 2634-2634. DOI: 10.1158/1538-7445.Am2015-2634 |
0.822 |
|
| 2014 |
Gasser JA, Inuzuka H, Lau AW, Wei W, Beroukhim R, Toker A. SGK3 mediates INPP4B-dependent PI3K signaling in breast cancer. Molecular Cell. 56: 595-607. PMID 25458846 DOI: 10.1016/J.Molcel.2014.09.023 |
0.803 |
|
| 2014 |
Clark AR, Toker A. Signalling specificity in the Akt pathway in breast cancer. Biochemical Society Transactions. 42: 1349-55. PMID 25233414 DOI: 10.1042/Bst20140160 |
0.598 |
|
| 2014 |
Chin YR, Yuan X, Balk SP, Toker A. PTEN-deficient tumors depend on AKT2 for maintenance and survival. Cancer Discovery. 4: 942-55. PMID 24838891 DOI: 10.1158/2159-8290.Cd-13-0873 |
0.496 |
|
| 2014 |
Toker A, Chin YR. Akt-ing up on SRPK1: oncogene or tumor suppressor? Molecular Cell. 54: 329-30. PMID 24813709 DOI: 10.1016/J.Molcel.2014.04.020 |
0.479 |
|
| 2014 |
Toker A, Marmiroli S. Signaling specificity in the Akt pathway in biology and disease. Advances in Biological Regulation. 55: 28-38. PMID 24794538 DOI: 10.1016/J.Jbior.2014.04.001 |
0.507 |
|
| 2014 |
Liu P, Begley M, Michowski W, Inuzuka H, Ginzberg M, Gao D, Tsou P, Gan W, Papa A, Kim BM, Wan L, Singh A, Zhai B, Yuan M, Wang Z, ... ... Toker A, et al. Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus. Nature. 508: 541-5. PMID 24670654 DOI: 10.1038/Nature13079 |
0.766 |
|
| 2014 |
Chin YR, Yoshida T, Marusyk A, Beck AH, Polyak K, Toker A. Targeting Akt3 signaling in triple-negative breast cancer. Cancer Research. 74: 964-73. PMID 24335962 DOI: 10.1158/0008-5472.Can-13-2175 |
0.547 |
|
| 2014 |
Elloul S, Kedrin D, Knoblauch NW, Beck AH, Toker A. The adherens junction protein afadin is an AKT substrate that regulates breast cancer cell migration. Molecular Cancer Research : McR. 12: 464-76. PMID 24269953 DOI: 10.1158/1541-7786.Mcr-13-0398 |
0.842 |
|
| 2014 |
Chin R, Balk SP, Toker A. Abstract 4421: PTEN-deficient tumors depend on Akt2 for maintenance Cancer Research. 74: 4421-4421. DOI: 10.1158/1538-7445.Am2014-4421 |
0.495 |
|
| 2013 |
White CD, Toker A. Using phospho-motif antibodies to determine kinase substrates. Current Protocols in Molecular Biology / Edited by Frederick M. Ausubel ... [Et Al.]. Unit 18.20.. PMID 23288461 DOI: 10.1002/0471142727.Mb1820S101 |
0.477 |
|
| 2013 |
Kazerounian S, Gerald D, Huang M, Chin YR, Udayakumar D, Zheng N, O'Donnell RK, Perruzzi C, Mangiante L, Pourat J, Phung TL, Bravo-Nuevo A, Shechter S, McNamara S, Duhadaway JB, ... ... Toker A, et al. RhoB differentially controls Akt function in tumor cells and stromal endothelial cells during breast tumorigenesis. Cancer Research. 73: 50-61. PMID 23135917 DOI: 10.1158/0008-5472.Can-11-3055 |
0.464 |
|
| 2013 |
Brown K, Toker A. Abstract 549: MAGI3-Akt3, a novel fusion protein in the PI 3-K pathway in cancer. Cancer Research. 73: 549-549. DOI: 10.1158/1538-7445.Am2013-549 |
0.565 |
|
| 2013 |
Collmann E, Toker A. Abstract 547: Inhibition of PI 3-K isoforms lead to reactivation of Akt signaling in a subset of breast cancer cell lines. Cancer Research. 73: 547-547. DOI: 10.1158/1538-7445.Am2013-547 |
0.573 |
|
| 2013 |
Kaunisto A, Toker A. Abstract 4998: NFAT signaling modulates tumor microenvironment. Cancer Research. 73: 4998-4998. DOI: 10.1158/1538-7445.Am2013-4998 |
0.448 |
|
| 2013 |
Chin YMR, Balk S, Toker A. Abstract 4090: Akt2-specific signaling in prostate cancer maintenance. Cancer Research. 73: 4090-4090. DOI: 10.1158/1538-7445.Am2013-4090 |
0.483 |
|
| 2013 |
Brown K, Toker A. Abstract B195: MAGI3-Akt3, a novel fusion protein in the PI3K pathway in cancer. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-B195 |
0.586 |
|
| 2012 |
Christoforides C, Rainero E, Brown KK, Norman JC, Toker A. PKD controls αvβ3 integrin recycling and tumor cell invasive migration through its substrate Rabaptin-5. Developmental Cell. 23: 560-72. PMID 22975325 DOI: 10.1016/J.Devcel.2012.08.008 |
0.523 |
|
| 2012 |
Inuzuka H, Gao D, Finley LW, Yang W, Wan L, Fukushima H, Chin YR, Zhai B, Shaik S, Lau AW, Wang Z, Gygi SP, Nakayama K, Teruya-Feldstein J, Toker A, et al. Acetylation-dependent regulation of Skp2 function. Cell. 150: 179-93. PMID 22770219 DOI: 10.1016/J.Cell.2012.05.038 |
0.461 |
|
| 2012 |
Banerji S, Cibulskis K, Rangel-Escareno C, Brown KK, Carter SL, Frederick AM, Lawrence MS, Sivachenko AY, Sougnez C, Zou L, Cortes ML, Fernandez-Lopez JC, Peng S, Ardlie KG, Auclair D, ... ... Toker A, et al. Sequence analysis of mutations and translocations across breast cancer subtypes. Nature. 486: 405-9. PMID 22722202 DOI: 10.1038/Nature11154 |
0.444 |
|
| 2012 |
Toker A. Phosphoinositide 3-kinases-a historical perspective. Sub-Cellular Biochemistry. 58: 95-110. PMID 22403075 DOI: 10.1007/978-94-007-3012-0_4 |
0.439 |
|
| 2012 |
Toker A. Achieving specificity in Akt signaling in cancer. Advances in Biological Regulation. 52: 78-87. PMID 21986444 DOI: 10.1016/J.Advenzreg.2011.09.020 |
0.563 |
|
| 2012 |
Banerji S, Cibulskis K, Rangel-Escareño C, Brown KK, Carter SL, Frederick AM, Lawrence MS, Sivachenko AY, Sougnez C, Zou L, Cortes ML, Fernandez-Lopez JC, Peng S, Ardlie KG, Auclair D, ... ... Toker A, et al. Abstract PL07-01: Molecular profiling of breast cancer in Mexico: Identification of novel therapeutic targets through whole genome sequencing analysis. Cancer Epidemiology, Biomarkers & Prevention. 21. DOI: 10.1158/1055-9965.Disp12-Pl07-01 |
0.416 |
|
| 2011 |
Gao D, Inuzuka H, Tan MK, Fukushima H, Locasale JW, Liu P, Wan L, Zhai B, Chin YR, Shaik S, Lyssiotis CA, Gygi SP, Toker A, Cantley LC, Asara JM, et al. mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR. Molecular Cell. 44: 290-303. PMID 22017875 DOI: 10.1016/J.Molcel.2011.08.030 |
0.795 |
|
| 2011 |
Yiu GK, Kaunisto A, Chin YR, Toker A. NFAT promotes carcinoma invasive migration through glypican-6. The Biochemical Journal. 440: 157-66. PMID 21871017 DOI: 10.1042/Bj20110530 |
0.523 |
|
| 2011 |
Chin YR, Toker A. Akt isoform-specific signaling in breast cancer: uncovering an anti-migratory role for palladin. Cell Adhesion & Migration. 5: 211-4. PMID 21519185 DOI: 10.4161/Cam.5.3.15790 |
0.563 |
|
| 2010 |
Chin YR, Toker A. Akt2 regulates expression of the actin-bundling protein palladin. Febs Letters. 584: 4769-74. PMID 21050850 DOI: 10.1016/J.Febslet.2010.10.056 |
0.574 |
|
| 2010 |
Gao D, Wan L, Inuzuka H, Berg AH, Tseng A, Zhai B, Shaik S, Bennett E, Tron AE, Gasser JA, Lau A, Gygi SP, Harper JW, DeCaprio JA, Toker A, et al. Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction. Molecular Cell. 39: 797-808. PMID 20832730 DOI: 10.1016/J.Molcel.2010.08.016 |
0.771 |
|
| 2010 |
Fry JL, Toker A. Secreted and membrane-bound isoforms of protease ADAM9 have opposing effects on breast cancer cell migration. Cancer Research. 70: 8187-98. PMID 20736367 DOI: 10.1158/0008-5472.Can-09-4231 |
0.779 |
|
| 2010 |
Chin YR, Toker A. The actin-bundling protein palladin is an Akt1-specific substrate that regulates breast cancer cell migration. Molecular Cell. 38: 333-44. PMID 20471940 DOI: 10.1016/J.Molcel.2010.02.031 |
0.566 |
|
| 2010 |
Nhek S, Ngo M, Yang X, Ng MM, Field SJ, Asara JM, Ridgway ND, Toker A. Regulation of oxysterol-binding protein Golgi localization through protein kinase D-mediated phosphorylation. Molecular Biology of the Cell. 21: 2327-37. PMID 20444975 DOI: 10.1091/Mbc.E10-02-0090 |
0.782 |
|
| 2010 |
Chin YMR, Toker A. Abstract 3838: Akt isoform-specific signaling in breast cancer cell invasive migration Cancer Research. 70: 3838-3838. DOI: 10.1158/1538-7445.Am10-3838 |
0.583 |
|
| 2009 |
Toker A. TTC3 ubiquitination terminates Akt-ivation. Developmental Cell. 17: 752-4. PMID 20059946 DOI: 10.1016/J.Devcel.2009.12.003 |
0.484 |
|
| 2009 |
Mancini M, Toker A. NFAT proteins: emerging roles in cancer progression. Nature Reviews. Cancer. 9: 810-20. PMID 19851316 DOI: 10.1038/Nrc2735 |
0.704 |
|
| 2009 |
Maurer M, Su T, Saal LH, Koujak S, Hopkins BD, Barkley CR, Wu J, Nandula S, Dutta B, Xie Y, Chin YR, Kim DI, Ferris JS, Gruvberger-Saal SK, Laakso M, ... ... Toker A, et al. 3-Phosphoinositide-dependent kinase 1 potentiates upstream lesions on the phosphatidylinositol 3-kinase pathway in breast carcinoma. Cancer Research. 69: 6299-306. PMID 19602588 DOI: 10.1158/0008-5472.Can-09-0820 |
0.587 |
|
| 2009 |
Storz P, Döppler H, Copland JA, Simpson KJ, Toker A. FOXO3a promotes tumor cell invasion through the induction of matrix metalloproteinases. Molecular and Cellular Biology. 29: 4906-17. PMID 19564415 DOI: 10.1128/Mcb.00077-09 |
0.615 |
|
| 2009 |
Gao D, Inuzuka H, Tseng A, Chin RY, Toker A, Wei W. Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction. Nature Cell Biology. 11: 397-408. PMID 19270695 DOI: 10.1038/Ncb1847 |
0.572 |
|
| 2009 |
Yoeli-Lerner M, Chin YR, Hansen CK, Toker A. Akt/protein kinase b and glycogen synthase kinase-3beta signaling pathway regulates cell migration through the NFAT1 transcription factor. Molecular Cancer Research : McR. 7: 425-32. PMID 19258413 DOI: 10.1158/1541-7786.Mcr-08-0342 |
0.562 |
|
| 2009 |
Chin YR, Toker A. Function of Akt/PKB signaling to cell motility, invasion and the tumor stroma in cancer. Cellular Signalling. 21: 470-6. PMID 19110052 DOI: 10.1016/J.Cellsig.2008.11.015 |
0.574 |
|
| 2009 |
Fry JL, Toker A. Abstract B8: The two isoforms of ADAM9 have opposing roles in breast cancer cell migration Cancer Research. 69. DOI: 10.1158/0008-5472.Fbcr09-B8 |
0.758 |
|
| 2008 |
Watkins JL, Lewandowski KT, Meek SE, Storz P, Toker A, Piwnica-Worms H. Phosphorylation of the Par-1 polarity kinase by protein kinase D regulates 14-3-3 binding and membrane association. Proceedings of the National Academy of Sciences of the United States of America. 105: 18378-83. PMID 19011111 DOI: 10.1073/Pnas.0809661105 |
0.711 |
|
| 2008 |
Toker A. mTOR and Akt signaling in cancer: SGK cycles in. Molecular Cell. 31: 6-8. PMID 18614042 DOI: 10.1016/J.Molcel.2008.06.007 |
0.499 |
|
| 2008 |
Toker A. Akt signaling: a damaging interaction makes good. Trends in Biochemical Sciences. 33: 356-9. PMID 18585043 DOI: 10.1016/J.Tibs.2008.05.003 |
0.429 |
|
| 2007 |
Kunkel MT, Toker A, Tsien RY, Newton AC. Calcium-dependent regulation of protein kinase D revealed by a genetically encoded kinase activity reporter. The Journal of Biological Chemistry. 282: 6733-42. PMID 17189263 DOI: 10.1074/Jbc.M608086200 |
0.406 |
|
| 2007 |
Toker A. Inhibiting the uninhibited: on the specificity of protein kinase inhibitors Biochemical Journal. DOI: 10.1042/Bj2007C003 |
0.455 |
|
| 2006 |
Toker A, Yoeli-Lerner M. Akt signaling and cancer: surviving but not moving on. Cancer Research. 66: 3963-6. PMID 16618711 DOI: 10.1158/0008-5472.Can-06-0743 |
0.551 |
|
| 2006 |
Yoeli-Lerner M, Toker A. Akt/PKB signaling in cancer: a function in cell motility and invasion. Cell Cycle (Georgetown, Tex.). 5: 603-5. PMID 16582622 DOI: 10.4161/Cc.5.6.2561 |
0.538 |
|
| 2006 |
Yiu GK, Toker A. NFAT induces breast cancer cell invasion by promoting the induction of cyclooxygenase-2. The Journal of Biological Chemistry. 281: 12210-7. PMID 16505480 DOI: 10.1074/jbc.M600184200 |
0.36 |
|
| 2005 |
Yoeli-Lerner M, Yiu GK, Rabinovitz I, Erhardt P, Jauliac S, Toker A. Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT. Molecular Cell. 20: 539-50. PMID 16307918 DOI: 10.1016/J.Molcel.2005.10.033 |
0.847 |
|
| 2005 |
Storz P, Döppler H, Toker A. Protein kinase D mediates mitochondrion-to-nucleus signaling and detoxification from mitochondrial reactive oxygen species. Molecular and Cellular Biology. 25: 8520-30. PMID 16166634 DOI: 10.1128/Mcb.25.19.8520-8530.2005 |
0.655 |
|
| 2005 |
Hausser A, Storz P, Märtens S, Link G, Toker A, Pfizenmaier K. Protein kinase D regulates vesicular transport by phosphorylating and activating phosphatidylinositol-4 kinase IIIbeta at the Golgi complex. Nature Cell Biology. 7: 880-6. PMID 16100512 DOI: 10.1038/Ncb1289 |
0.696 |
|
| 2005 |
Mazzocca A, Coppari R, De Franco R, Cho JY, Libermann TA, Pinzani M, Toker A. A secreted form of ADAM9 promotes carcinoma invasion through tumor-stromal interactions. Cancer Research. 65: 4728-38. PMID 15930291 DOI: 10.1158/0008-5472.Can-04-4449 |
0.356 |
|
| 2005 |
Toker A. The biology and biochemistry of diacylglycerol signalling. Meeting on molecular advances in diacylglycerol signalling. Embo Reports. 6: 310-4. PMID 15791268 DOI: 10.1038/Sj.Embor.7400378 |
0.456 |
|
| 2005 |
Döppler H, Storz P, Li J, Comb MJ, Toker A. A phosphorylation state-specific antibody recognizes Hsp27, a novel substrate of protein kinase D. The Journal of Biological Chemistry. 280: 15013-9. PMID 15728188 DOI: 10.1074/Jbc.C400575200 |
0.644 |
|
| 2005 |
Storz P, Döppler H, Ferran C, Grey ST, Toker A. Functional dichotomy of A20 in apoptotic and necrotic cell death Biochemical Journal. 387: 47-55. PMID 15527421 DOI: 10.1042/Bj20041443 |
0.598 |
|
| 2004 |
Hutti JE, Jarrell ET, Chang JD, Abbott DW, Storz P, Toker A, Cantley LC, Turk BE. A rapid method for determining protein kinase phosphorylation specificity. Nature Methods. 1: 27-9. PMID 15782149 DOI: 10.1038/Nmeth708 |
0.774 |
|
| 2004 |
Hodges RR, Raddassi I, Zoukhri D, Toker A, Kazlauskas A, Dartt DA. Effect of overexpression of constitutively active PKCalpha on rat lacrimal gland protein secretion. Investigative Ophthalmology & Visual Science. 45: 3974-81. PMID 15505044 DOI: 10.1167/Iovs.04-0508 |
0.339 |
|
| 2004 |
Storz P, Döppler H, Toker A. Activation loop phosphorylation controls protein kinase D-dependent activation of nuclear factor kappaB. Molecular Pharmacology. 66: 870-9. PMID 15226414 DOI: 10.1124/Mol.104.000687 |
0.696 |
|
| 2004 |
Storz P, Döppler H, Toker A. Protein kinase Cdelta selectively regulates protein kinase D-dependent activation of NF-kappaB in oxidative stress signaling. Molecular and Cellular Biology. 24: 2614-26. PMID 15024053 DOI: 10.1128/Mcb.24.7.2614-2626.2004 |
0.7 |
|
| 2003 |
Toker A. Genetic manipulation of protein kinase C in vivo. Methods in Molecular Biology (Clifton, N.J.). 233: 475-89. PMID 12840530 DOI: 10.1385/1-59259-397-6:475 |
0.382 |
|
| 2003 |
Toker A. Identifying protein kinase C substrates: an introduction. Methods in Molecular Biology (Clifton, N.J.). 233: 247-51. PMID 12840512 DOI: 10.1385/1-59259-397-6:247 |
0.412 |
|
| 2003 |
Toker A. PDK-1 and protein kinase C phosphorylation. Methods in Molecular Biology (Clifton, N.J.). 233: 171-89. PMID 12840507 DOI: 10.1385/1-59259-397-6:171 |
0.444 |
|
| 2003 |
Storz P, Toker A. NF-kappaB signaling--an alternate pathway for oxidative stress responses. Cell Cycle (Georgetown, Tex.). 2: 9-10. PMID 12695674 DOI: 10.4161/Cc.2.1.234 |
0.59 |
|
| 2003 |
Storz P, Döppler H, Johannes FJ, Toker A. Tyrosine phosphorylation of protein kinase D in the pleckstrin homology domain leads to activation. The Journal of Biological Chemistry. 278: 17969-76. PMID 12637538 DOI: 10.1074/Jbc.M213224200 |
0.705 |
|
| 2003 |
Storz P, Toker A. Protein kinase D mediates a stress-induced NF-kappaB activation and survival pathway. The Embo Journal. 22: 109-20. PMID 12505989 DOI: 10.1093/Emboj/Cdg009 |
0.674 |
|
| 2002 |
Toker A. Phosphoinositides and signal transduction. Cellular and Molecular Life Sciences. 59: 761-779. PMID 12088277 DOI: 10.1007/S00018-002-8465-Z |
0.442 |
|
| 2002 |
Jauliac S, López-Rodriguez C, Shaw LM, Brown LF, Rao A, Toker A. The role of NFAT transcription factors in integrin-mediated carcinoma invasion. Nature Cell Biology. 4: 540-4. PMID 12080349 DOI: 10.1038/Ncb816 |
0.78 |
|
| 2002 |
Cenni V, Döppler H, Sonnenburg ED, Maraldi N, Newton AC, Toker A. Regulation of novel protein kinase C epsilon by phosphorylation. The Biochemical Journal. 363: 537-45. PMID 11964154 DOI: 10.1042/0264-6021:3630537 |
0.508 |
|
| 2002 |
Storz P, Toker A. 3'-phosphoinositide-dependent kinase-1 (PDK-1) in PI 3-kinase signaling. Frontiers in Bioscience : a Journal and Virtual Library. 7: d886-902. PMID 11897568 DOI: 10.2741/Storz |
0.733 |
|
| 2002 |
CENNI V, DÖPPLER H, SONNENBURG ED, MARALDI N, NEWTON AC, TOKER A. Regulation of novel protein kinase C ε by phosphorylation Biochemical Journal. 363: 537-545. DOI: 10.1042/bj3630537 |
0.412 |
|
| 2001 |
Gao T, Toker A, Newton AC. The carboxyl terminus of protein kinase c provides a switch to regulate its interaction with the phosphoinositide-dependent kinase, PDK-1. The Journal of Biological Chemistry. 276: 19588-96. PMID 11376011 DOI: 10.1074/Jbc.M101357200 |
0.489 |
|
| 2001 |
Lian JP, Toker A, Badwey JA. Phosphorylation of the activation loop of gamma p21-activated kinase (gamma-Pak) and related kinases (MSTs) in normal and stressed neutrophils. Journal of Immunology (Baltimore, Md. : 1950). 166: 6349-57. PMID 11342659 DOI: 10.4049/Jimmunol.166.10.6349 |
0.458 |
|
| 2001 |
Lian JP, Crossley L, Zhan Q, Huang R, Coffer P, Toker A, Robinson D, Badwey JA. Antagonists of Calcium Fluxes and Calmodulin Block Activation of the p21-Activated Protein Kinases in Neutrophils Journal of Immunology. 166: 2643-2650. PMID 11160327 DOI: 10.4049/Jimmunol.166.4.2643 |
0.387 |
|
| 2000 |
Toker A, Newton AC. Cellular signaling: pivoting around PDK-1. Cell. 103: 185-8. PMID 11057891 DOI: 10.1016/S0092-8674(00)00110-0 |
0.35 |
|
| 2000 |
Toker A, Newton AC. Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site. The Journal of Biological Chemistry. 275: 8271-4. PMID 10722653 DOI: 10.1074/Jbc.275.12.8271 |
0.476 |
|
| 2000 |
Bavelloni A, Faenza I, Aluigi M, Ferri A, Toker A, Maraldi NM, Marmiroli S. Inhibition of phosphoinositide 3-kinase impairs pre-commitment cell cycle traverse and prevents differentiation in erythroleukaemia cells. Cell Death and Differentiation. 7: 112-7. PMID 10713726 DOI: 10.1038/Sj.Cdd.4400591 |
0.477 |
|
| 2000 |
Balciunaite E, Jones S, Toker A, Kazlauskas A. PDGF initiates two distinct phases of protein kinase C activity that make unequal contributions to the G0 to S transition. Current Biology : Cb. 10: 261-7. PMID 10712903 DOI: 10.1016/S0960-9822(00)00358-4 |
0.427 |
|
| 2000 |
Toker A. Protein Kinases as Mediators of Phosphoinositide 3-Kinase Signaling Molecular Pharmacology. 57: 652-658. DOI: 10.1124/Mol.57.4.652 |
0.513 |
|
| 2000 |
Hodges RR, Kazlauskas A, Toker A, Darlene A. EFFECT OF OVEREXPRESSION OF PROTEIN KINASE Cα ON RAT LACRIMAL GLAND PROTEIN SECRETION. Cornea. 19. DOI: 10.1097/00003226-200011002-00079 |
0.371 |
|
| 1999 |
Robinson D, Huang R, Lian JP, Toker A, Badwey JA. Functions of the p21-activated protein kinases (Paks) in neutrophils and their regulation by complex lipids. Advances in Experimental Medicine and Biology. 469: 385-390. PMID 10667357 DOI: 10.1007/978-1-4615-4793-8_56 |
0.406 |
|
| 1999 |
Feranchak AP, Roman RM, Doctor RB, Salter KD, Toker A, Fitz JG. The lipid products of phosphoinositide 3-kinase contribute to regulation of cholangiocyte ATP and chloride transport. The Journal of Biological Chemistry. 274: 30979-86. PMID 10521494 DOI: 10.1074/jbc.274.43.30979 |
0.374 |
|
| 1999 |
Rabinovitz I, Toker A, Mercurio AM. Protein kinase C-dependent mobilization of the alpha6beta4 integrin from hemidesmosomes and its association with actin-rich cell protrusions drive the chemotactic migration of carcinoma cells. The Journal of Cell Biology. 146: 1147-60. PMID 10477766 DOI: 10.1083/Jcb.146.5.1147 |
0.425 |
|
| 1999 |
Standaert ML, Bandyopadhyay G, Perez L, Price D, Galloway L, Poklepovic A, Sajan MP, Cenni V, Sirri A, Moscat J, Toker A, Farese RV. Insulin activates protein kinases C-zeta and C-lambda by an autophosphorylation-dependent mechanism and stimulates their translocation to GLUT4 vesicles and other membrane fractions in rat adipocytes. The Journal of Biological Chemistry. 274: 25308-16. PMID 10464256 DOI: 10.1074/JBC.274.36.25308 |
0.338 |
|
| 1999 |
Paradis S, Ailion M, Toker A, Thomas JH, Ruvkun G. A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans. Genes & Development. 13: 1438-52. PMID 10364160 DOI: 10.1101/Gad.13.11.1438 |
0.481 |
|
| 1999 |
Jones SM, Klinghoffer R, Prestwich GD, Toker A, Kazlauskas A. PDGF induces an early and a late wave of PI 3-kinase activity, and only the late wave is required for progression through G1. Current Biology : Cb. 9: 512-21. PMID 10339426 DOI: 10.1016/S0960-9822(99)80235-8 |
0.442 |
|
| 1999 |
Romanelli A, Martin KA, Toker A, Blenis J. p70 S6 kinase is regulated by protein kinase Czeta and participates in a phosphoinositide 3-kinase-regulated signalling complex. Molecular and Cellular Biology. 19: 2921-8. PMID 10082559 DOI: 10.1128/Mcb.19.4.2921 |
0.53 |
|
| 1999 |
Lian JP, Huang R, Crossley L, Robinson D, Toker A, Badwey JA. Regulation of the P21-activated protein kinases (PAKS) in neutrophils by phosphoinositides and sphingolipids Prostaglandins & Other Lipid Mediators. 59: 30. DOI: 10.1016/S0090-6980(99)90265-4 |
0.472 |
|
| 1998 |
Dutil EM, Toker A, Newton AC. Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1). Current Biology : Cb. 8: 1366-75. PMID 9889098 DOI: 10.1016/S0960-9822(98)00017-7 |
0.494 |
|
| 1998 |
Marmiroli S, Bavelloni A, Faenza I, Sirri A, Ognibene A, Cenni V, Tsukada J, Koyama Y, Ruzzene M, Ferri A, Auron PE, Toker A, Maraldi NM. Phosphatidylinositol 3-kinase is recruited to a specific site in the activated IL-1 receptor I. Febs Letters. 438: 49-54. PMID 9821957 DOI: 10.1016/S0014-5793(98)01270-8 |
0.374 |
|
| 1998 |
Toker A. Signaling through protein kinase C. Frontiers in Bioscience : a Journal and Virtual Library. 3: D1134-47. PMID 9792904 DOI: 10.2741/A350 |
0.536 |
|
| 1998 |
Chou MM, Hou W, Johnson J, Graham LK, Lee MH, Chen CS, Newton AC, Schaffhausen BS, Toker A. Regulation of protein kinase C zeta by PI 3-kinase and PDK-1. Current Biology : Cb. 8: 1069-77. PMID 9768361 DOI: 10.1016/S0960-9822(98)70444-0 |
0.519 |
|
| 1998 |
Nishikawa K, Toker A, Wong K, Marignani PA, Johannes FJ, Cantley LC. Association of protein kinase Cmu with type II phosphatidylinositol 4-kinase and type I phosphatidylinositol-4-phosphate 5-kinase. The Journal of Biological Chemistry. 273: 23126-33. PMID 9722541 DOI: 10.1074/Jbc.273.36.23126 |
0.59 |
|
| 1998 |
Toker A. The synthesis and cellular roles of phosphatidylinositol 4,5-bisphosphate. Current Opinion in Cell Biology. 10: 254-61. PMID 9561850 DOI: 10.1016/S0955-0674(98)80148-8 |
0.405 |
|
| 1998 |
Shaw LM, Rabinovitz I, Wang HH, Toker A, Mercurio AM. Activation of phosphoinositide 3-OH kinase by the alpha6beta4 integrin promotes carcinoma invasion. Cell. 91: 949-60. PMID 9428518 DOI: 10.1016/S0092-8674(00)80486-9 |
0.452 |
|
| 1997 |
Toker A, Cantley LC. Signalling through the lipid products of phosphoinositide-3-OH kinase. Nature. 387: 673-6. PMID 9192891 DOI: 10.1038/42648 |
0.541 |
|
| 1997 |
Klingmüller U, Wu H, Hsiao JG, Toker A, Duckworth BC, Cantley LC, Lodish HF. Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors. Proceedings of the National Academy of Sciences of the United States of America. 94: 3016-21. PMID 9096338 DOI: 10.1073/Pnas.94.7.3016 |
0.636 |
|
| 1997 |
Derman MP, Toker A, Hartwig JH, Spokes K, Falck JR, Chen CS, Cantley LC, Cantley LG. The lipid products of phosphoinositide 3-kinase increase cell motility through protein kinase C. The Journal of Biological Chemistry. 272: 6465-70. PMID 9045671 DOI: 10.1074/Jbc.272.10.6465 |
0.59 |
|
| 1997 |
Zoukhri D, Hodges RR, Sergheraert C, Toker A, Dartt DA. Lacrimal gland PKC isoforms are differentially involved in agonist-induced protein secretion American Journal of Physiology-Cell Physiology. 272. PMID 9038832 DOI: 10.1152/Ajpcell.1997.272.1.C263 |
0.338 |
|
| 1997 |
Franke TF, Kaplan DR, Cantley LC, Toker A. Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate Science. 275: 665-668. PMID 9005852 DOI: 10.1126/Science.275.5300.665 |
0.574 |
|
| 1997 |
Nishikawa K, Toker A, Johannes FJ, Songyang Z, Cantley LC. Determination of the specific substrate sequence motifs of protein kinase C isozymes. The Journal of Biological Chemistry. 272: 952-60. PMID 8995387 DOI: 10.1074/Jbc.272.2.952 |
0.467 |
|
| 1997 |
Hartwig JH, Kung S, Kovacsovics T, Janmey PA, Cantley LC, Stossel TP, Toker A. D3 phosphoinositides and outside-in integrin signaling by glycoprotein IIb-IIIa mediate platelet actin assembly and filopodial extension induced by phorbol 12-myristate 13-acetate. The Journal of Biological Chemistry. 271: 32986-93. PMID 8955143 DOI: 10.1074/Jbc.271.51.32986 |
0.521 |
|
| 1996 |
Sossin WS, Chen CS, Toker A. Stimulation of an insulin receptor activates and down-regulates the Ca2+-independent protein kinase C, Apl II, through a Wortmannin-sensitive signaling pathway in Aplysia. Journal of Neurochemistry. 67: 220-8. PMID 8666995 DOI: 10.1046/J.1471-4159.1996.67010220.X |
0.477 |
|
| 1996 |
Toker A, Bachelot C, Chen CS, Falck JR, Hartwig JH, Cantley LC, Kovacsovics TJ. Phosphorylation of the platelet p47 phosphoprotein is mediated by the lipid products of phosphoinositide 3-kinase. The Journal of Biological Chemistry. 270: 29525-31. PMID 7493994 DOI: 10.1074/Jbc.270.49.29525 |
0.555 |
|
| 1995 |
Kovacsovics TJ, Bachelot C, Toker A, Vlahos CJ, Duckworth B, Cantley LC, Hartwig JH. Phosphoinositide 3-kinase inhibition spares actin assembly in activating platelets but reverses platelet aggregation. The Journal of Biological Chemistry. 270: 11358-66. PMID 7744773 DOI: 10.1074/Jbc.270.19.11358 |
0.497 |
|
| 1995 |
Kapeller R, Toker A, Cantley LC, Carpenter CL. Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin. The Journal of Biological Chemistry. 270: 25985-91. PMID 7592789 DOI: 10.1074/Jbc.270.43.25985 |
0.578 |
|
| 1995 |
Soltoff SP, Toker A. Carbachol, substance P, and phorbol ester promote the tyrosine phosphorylation of protein kinase C delta in salivary gland epithelial cells. The Journal of Biological Chemistry. 270: 13490-5. PMID 7539427 DOI: 10.1074/Jbc.270.22.13490 |
0.464 |
|
| 1992 |
Aitken A, Amess B, Howell S, Jones D, Martin H, Patel Y, Robinson K, Toker A. The role of specific isoforms of 14-3-3 protein in regulating protein kinase activity in the brain. Biochemical Society Transactions. 20: 607-11. PMID 1426598 DOI: 10.1042/bst0200607 |
0.304 |
|
| 1990 |
Aitken A, Ellis CA, Harris A, Sellers LA, Toker A. Kinase and neurotransmitters. Nature. 344: 594. PMID 1970123 DOI: 10.1038/344594A0 |
0.459 |
|
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