| Year |
Citation |
Score |
| 2024 |
Aljagthmi AA, Hira A, Zhang J, Cooke M, Kazanietz MG, Kadakia MP. ∆Np63α inhibits Rac1 activation and cancer cell invasion through suppression of PREX1. Cell Death Discovery. 10: 13. PMID 38191532 DOI: 10.1038/s41420-023-01789-0 |
0.378 |
|
| 2023 |
Cooke M, Zhang S, Maciel FC, Kazanietz MG. Gi/o GPCRs drive the formation of actin-rich tunneling nanotubes in cancer cells via a Gβγ/PKCα/FARP1/Cdc42 axis. The Journal of Biological Chemistry. 104983. PMID 37390986 DOI: 10.1016/j.jbc.2023.104983 |
0.309 |
|
| 2022 |
Medina JI, Cruz-Collazo A, Del Mar Maldonado M, Gascot TM, Borrero-Garcia LD, Cooke M, Kazanietz MG, O'Farril EH, Vlaar CP, Dharmawardhane S. Characterization of Novel Derivatives of MBQ-167, an inhibitor of the GTP-binding proteins Rac/Cdc42. Cancer Research Communications. 2: 1711-1726. PMID 36861094 DOI: 10.1158/2767-9764.crc-22-0303 |
0.376 |
|
| 2022 |
Cooke M, Zhang X, Zhang S, Eruslanov E, Lal P, Daniel RE, Feldman MD, Abba MC, Kazanietz MG. PROTEIN KINASE C ALPHA IS A CENTRAL NODE FOR TUMORIGENIC TRANSCRIPTIONAL NETWORKS IN HUMAN PROSTATE CANCER. Cancer Research Communications. 2: 1372-1387. PMID 36818489 DOI: 10.1158/2767-9764.crc-22-0170 |
0.362 |
|
| 2022 |
Cooke M, Kazanietz MG. Overarching roles of diacylglycerol signaling in cancer development and antitumor immunity. Science Signaling. 15: eabo0264. PMID 35412850 DOI: 10.1126/scisignal.abo0264 |
0.389 |
|
| 2021 |
Cooke M, Kreider-Letterman G, Baker MJ, Zhang S, Sullivan NT, Eruslanov E, Abba MC, Goicoechea SM, García-Mata R, Kazanietz MG. FARP1, ARHGEF39, and TIAM2 are essential receptor tyrosine kinase effectors for Rac1-dependent cell motility in human lung adenocarcinoma. Cell Reports. 37: 109905. PMID 34731623 DOI: 10.1016/j.celrep.2021.109905 |
0.336 |
|
| 2020 |
Rahimova N, Cooke M, Zhang S, Baker MJ, Kazanietz MG. The PKC universe keeps expanding: From cancer initiation to metastasis. Advances in Biological Regulation. 78: 100755. PMID 33017725 DOI: 10.1016/j.jbior.2020.100755 |
0.406 |
|
| 2020 |
Zhang S, Kazanietz MG, Cooke M. Rho GTPases and the emerging role of tunneling nanotubes in physiology and disease. American Journal of Physiology. Cell Physiology. PMID 32845720 DOI: 10.1152/Ajpcell.00351.2020 |
0.373 |
|
| 2020 |
Baker MJ, Cooke M, Kreider-Letterman G, Garcia-Mata R, Janmey PA, Kazanietz MG. Evaluation of active Rac1 levels in cancer cells: a case of misleading conclusions from immunofluorescence analysis. The Journal of Biological Chemistry. PMID 32817335 DOI: 10.1074/Jbc.Ra120.013919 |
0.435 |
|
| 2020 |
Cooke M, Baker MJ, Kazanietz MG. Rac-GEF/Rac Signaling and Metastatic Dissemination in Lung Cancer. Frontiers in Cell and Developmental Biology. 8: 118. PMID 32158759 DOI: 10.3389/Fcell.2020.00118 |
0.439 |
|
| 2020 |
Baker MJ, Abba MC, Garcia-Mata R, Kazanietz MG. P-REX1-Independent, Calcium-Dependent RAC1 Hyperactivation in Prostate Cancer. Cancers. 12. PMID 32092966 DOI: 10.3390/Cancers12020480 |
0.429 |
|
| 2020 |
Aljagthmi AA, Cooke M, Kazanietz M, Kadakia MP. ΔNp63α suppresses cell invasion through downregulating Rac1 activity The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.02084 |
0.366 |
|
| 2019 |
Casado-Medrano V, Barrio-Real L, Gutiérrez-Miranda L, González-Sarmiento R, Velasco EA, Kazanietz MG, Caloca MJ. Identification of a truncated β1-chimaerin variant that inactivates nuclear Rac1. The Journal of Biological Chemistry. PMID 31871052 DOI: 10.1074/Jbc.Ra119.008688 |
0.352 |
|
| 2019 |
Llorens MC, Rossi FA, García IA, Cooke M, Abba MC, Lopez-Haber C, Barrio-Real L, Vaglienti MV, Rossi M, Bocco JL, Kazanietz MG, Soria G. PKCα Modulates Epithelial-to-Mesenchymal Transition and Invasiveness of Breast Cancer Cells Through ZEB1. Frontiers in Oncology. 9: 1323. PMID 31828042 DOI: 10.3389/Fonc.2019.01323 |
0.475 |
|
| 2019 |
Cooke M, Baker MJ, Kazanietz MG, Casado-Medrano V. PKCε regulates Rho GTPases and actin cytoskeleton reorganization in non-small cell lung cancer cells. Small Gtpases. PMID 31648598 DOI: 10.1080/21541248.2019.1684785 |
0.488 |
|
| 2019 |
Aljagthmi AA, Hill NT, Cooke M, Kazanietz MG, Abba MC, Long W, Kadakia MP. ΔNp63α suppresses cells invasion by downregulating PKCγ/Rac1 signaling through miR-320a. Cell Death & Disease. 10: 680. PMID 31515469 DOI: 10.1038/S41419-019-1921-6 |
0.332 |
|
| 2019 |
Kazanietz MG, Durando M, Cooke M. CXCL13 and Its Receptor CXCR5 in Cancer: Inflammation, Immune Response, and Beyond. Frontiers in Endocrinology. 10: 471. PMID 31354634 DOI: 10.3389/Fendo.2019.00471 |
0.434 |
|
| 2019 |
Neuman I, Cooke M, Lemiña NA, Kazanietz MG, Cornejo Maciel F. 5-oxo-ETE activates migration of H295R adrenocortical cells via MAPK and PKC pathways. Prostaglandins & Other Lipid Mediators. 106346. PMID 31301403 DOI: 10.1016/J.Prostaglandins.2019.106346 |
0.398 |
|
| 2019 |
Cooke M, Casado-Medrano V, Ann J, Lee J, Blumberg PM, Abba MC, Kazanietz MG. Differential Regulation of Gene Expression in Lung Cancer Cells by Diacyglycerol-Lactones and a Phorbol Ester Via Selective Activation of Protein Kinase C Isozymes. Scientific Reports. 9: 6041. PMID 30988374 DOI: 10.1038/S41598-019-42581-4 |
0.44 |
|
| 2019 |
Casado-Medrano V, Barrio-Real L, Wang A, Cooke M, Lopez-Haber C, Kazanietz MG. Distinctive requirement of PKCε in the control of Rho GTPases in epithelial and mesenchymally transformed lung cancer cells. Oncogene. PMID 30923343 DOI: 10.1038/S41388-019-0796-4 |
0.474 |
|
| 2018 |
Casado-Medrano V, Baker MJ, Lopez-Haber C, Cooke M, Wang S, Caloca MJ, Kazanietz MG. The role of Rac in tumor susceptibility and disease progression: from biochemistry to the clinic. Biochemical Society Transactions. PMID 30065108 DOI: 10.1042/Bst20170519 |
0.422 |
|
| 2018 |
Barrio-Real L, Lopez-Haber C, Casado-Medrano V, Goglia AG, Toettcher JE, Caloca MJ, Kazanietz MG. P-Rex1 is dispensable for Erk activation and mitogenesis in breast cancer. Oncotarget. 9: 28612-28624. PMID 29983884 DOI: 10.18632/Oncotarget.25584 |
0.458 |
|
| 2018 |
Garg R, Blando JM, Perez CJ, Lal P, Feldman MD, Smyth EM, Ricciotti E, Grosser T, Benavides F, Kazanietz MG. COX-2 mediates pro-tumorigenic effects of PKCε in prostate cancer. Oncogene. PMID 29765153 DOI: 10.1038/S41388-018-0318-9 |
0.37 |
|
| 2018 |
Cooke M, Zhou X, Casado-Medrano V, Lopez-Haber C, Baker MJ, Garg R, Ann J, Lee J, Blumberg PM, Kazanietz MG. Characterization of AJH-836, a DAG-lactone with selectivity for novel PKC isozymes. The Journal of Biological Chemistry. PMID 29636415 DOI: 10.1074/Jbc.Ra117.000235 |
0.52 |
|
| 2018 |
Bessa C, Soares J, Raimundo L, Loureiro JB, Gomes C, Reis F, Soares ML, Santos D, Dureja C, Chaudhuri SR, Lopez-Haber C, Kazanietz MG, Gonçalves J, Simões MF, Rijo P, et al. Discovery of a small-molecule protein kinase Cδ-selective activator with promising application in colon cancer therapy. Cell Death & Disease. 9: 23. PMID 29348560 DOI: 10.1038/S41419-017-0154-9 |
0.504 |
|
| 2017 |
Kazanietz MG, Caloca MJ. The Rac GTPase in cancer: from old concepts to new paradigms. Cancer Research. PMID 28807941 DOI: 10.1158/0008-5472.Can-17-1456 |
0.462 |
|
| 2017 |
Garg R, Blando JM, Perez CJ, Abba MC, Benavides F, Kazanietz MG. Protein Kinase C Epsilon Cooperates with PTEN Loss for Prostate Tumorigenesis through the CXCL13-CXCR5 Pathway. Cell Reports. 19: 375-388. PMID 28402859 DOI: 10.1016/J.Celrep.2017.03.042 |
0.441 |
|
| 2017 |
Baker MJ, Cooke M, Kazanietz MG. Nuclear PKCι-ECT2-Rac1 and Ribosome Biogenesis: A Novel Axis in Lung Tumorigenesis. Cancer Cell. 31: 167-169. PMID 28196591 DOI: 10.1016/J.Ccell.2017.01.008 |
0.397 |
|
| 2017 |
Cooke M, Magimaidas A, Casado-Medrano V, Kazanietz MG. Protein kinase C in cancer: The top five unanswered questions. Molecular Carcinogenesis. PMID 28112438 DOI: 10.1002/Mc.22617 |
0.488 |
|
| 2017 |
Garg R, Blando J, Perez C, Abba M, Benavides F, Kazanietz M. Abstract LB-230: Oncogenic PKC epsilon and Pten loss converge on activating CXCL13 via atypical NF-κB transcriptional signaling in prostate cancer progression Cancer Research. 77. DOI: 10.1158/1538-7445.Am2017-Lb-230 |
0.375 |
|
| 2016 |
Kazanietz MG, Barrio-Real L, Casado-Medrano V, Baker MJ, Lopez-Haber C. The P-Rex1/Rac signaling pathway as a point of convergence for HER/ErbB receptor and GPCR responses. Small Gtpases. 1-7. PMID 27588611 DOI: 10.1080/21541248.2016.1221273 |
0.423 |
|
| 2016 |
Barrio-Real L, Wertheimer E, Garg R, Abba MC, Kazanietz MG. Characterization of a P-Rex1 gene signature in breast cancer cells. Oncotarget. PMID 27351228 DOI: 10.18632/Oncotarget.10285 |
0.42 |
|
| 2016 |
Priego N, Arechederra M, Sequera C, Bragado P, Vázquez-Carballo A, Gutiérrez-Uzquiza Á, Martín-Granado V, Ventura JJ, Kazanietz MG, Guerrero C, Porras A. C3G knock-down enhances migration and invasion by increasing Rap1-mediated p38α activation, while it impairs tumor growth through p38α-independent mechanisms. Oncotarget. PMID 27286263 DOI: 10.18632/Oncotarget.9911 |
0.413 |
|
| 2016 |
Lopez-Haber C, Barrio-Real L, Casado-Medrano V, Kazanietz MG. HEREGULIN/ErbB3 SIGNALING ENHANCES CXCR4-DRIVEN Rac1 ACTIVATION AND BREAST CANCER CELL MOTILITY VIA HIF-1α. Molecular and Cellular Biology. PMID 27185877 DOI: 10.1128/Mcb.00180-16 |
0.41 |
|
| 2016 |
Garg R, Kapoor V, Abba M, Feldser DM, Albelda SM, Kazanietz MG. Abstract 5164: Protein kinase C epsilon is a mediator of KRAS-driven lung tumorigenesis Cancer Research. 76: 5164-5164. DOI: 10.1158/1538-7445.Am2016-5164 |
0.414 |
|
| 2015 |
Gutierrez-Uzquiza A, Lopez-Haber C, Jernigan DL, Fatatis A, Kazanietz MG. PKCε Is an Essential Mediator of Prostate Cancer Bone Metastasis. Molecular Cancer Research : McR. 13: 1336-46. PMID 26023164 DOI: 10.1158/1541-7786.Mcr-15-0111 |
0.403 |
|
| 2015 |
Abera MB, Kazanietz MG. Protein kinase Cα mediates erlotinib resistance in lung cancer cells. Molecular Pharmacology. 87: 832-41. PMID 25724832 DOI: 10.1124/Mol.115.097725 |
0.78 |
|
| 2015 |
Garg R, Blando J, Perez CJ, Benavides FJ, Kazanietz MG. Abstract 799: Protein kinase C ε cooperates with Pten deficiency to regulate NF-κB pathway in prostate cancer progression Cancer Research. 75: 799-799. DOI: 10.1158/1538-7445.Am2015-799 |
0.431 |
|
| 2014 |
Barrio-Real L, Benedetti LG, Engel N, Tu Y, Cho S, Sukumar S, Kazanietz MG. Subtype-specific overexpression of the Rac-GEF P-REX1 in breast cancer is associated with promoter hypomethylation. Breast Cancer Research : Bcr. 16: 441. PMID 25248717 DOI: 10.1186/S13058-014-0441-7 |
0.342 |
|
| 2014 |
Wang H, Gutierrez-Uzquiza A, Garg R, Barrio-Real L, Abera MB, Lopez-Haber C, Rosemblit C, Lu H, Abba M, Kazanietz MG. Transcriptional regulation of oncogenic protein kinase Cϵ (PKCϵ) by STAT1 and Sp1 proteins. The Journal of Biological Chemistry. 289: 19823-38. PMID 24825907 DOI: 10.1074/Jbc.M114.548446 |
0.778 |
|
| 2014 |
Zubeldia-Brenner L, Gutierrez-Uzquiza A, Barrio-Real L, Wang H, Kazanietz MG, Leskow FC. β3-chimaerin, a novel member of the chimaerin Rac-GAP family. Molecular Biology Reports. 41: 2067-76. PMID 24430297 DOI: 10.1007/S11033-014-3055-3 |
0.507 |
|
| 2014 |
Garg R, Benedetti LG, Abera MB, Wang H, Abba M, Kazanietz MG. Protein kinase C and cancer: what we know and what we do not. Oncogene. 33: 5225-37. PMID 24336328 DOI: 10.1038/Onc.2013.524 |
0.788 |
|
| 2014 |
Garg R, Abba M, Kazanietz MG. Abstract 1596: CXCL13 as a mediator of oncogenic PKCε in prostate cancer Cancer Research. 74: 1596-1596. DOI: 10.1158/1538-7445.Am2014-1596 |
0.442 |
|
| 2013 |
Garg R, Caino MC, Kazanietz MG. Regulation of Transcriptional Networks by PKC Isozymes: Identification of c-Rel as a Key Transcription Factor for PKC-Regulated Genes. Plos One. 8: e67319. PMID 23826267 DOI: 10.1371/Journal.Pone.0067319 |
0.482 |
|
| 2013 |
Cirigliano SM, Mauro LV, Grossoni VC, Colombo LL, Diament MJ, Kazanietz MG, Bal de Kier Joffé ED, Puricelli LI, Urtreger AJ. Modulation of pancreatic tumor potential by overexpression of protein kinase C β1. Pancreas. 42: 1060-9. PMID 23695799 DOI: 10.1097/Mpa.0B013E31828Fd141 |
0.407 |
|
| 2013 |
Dipaolo BC, Davidovich N, Kazanietz MG, Margulies SS. Rac1 pathway mediates stretch response in pulmonary alveolar epithelial cells. American Journal of Physiology. Lung Cellular and Molecular Physiology. 305: L141-53. PMID 23686855 DOI: 10.1152/Ajplung.00298.2012 |
0.442 |
|
| 2013 |
Gutierrez-Uzquiza A, Colon-Gonzalez F, Leonard TA, Canagarajah BJ, Wang H, Mayer BJ, Hurley JH, Kazanietz MG. Coordinated activation of the Rac-GAP β2-chimaerin by an atypical proline-rich domain and diacylglycerol. Nature Communications. 4: 1849. PMID 23673634 DOI: 10.1038/Ncomms2834 |
0.786 |
|
| 2013 |
Lopez-Haber C, Kazanietz MG. Cucurbitacin I inhibits Rac1 activation in breast cancer cells by a reactive oxygen species-mediated mechanism and independently of Janus tyrosine kinase 2 and P-Rex1. Molecular Pharmacology. 83: 1141-54. PMID 23478800 DOI: 10.1124/Mol.112.084293 |
0.481 |
|
| 2013 |
Sviridonov L, Dobkin-Bekman M, Shterntal B, Przedecki F, Formishell L, Kravchook S, Rahamim-Ben Navi L, Bar-Lev TH, Kazanietz MG, Yao Z, Seger R, Naor Z. Differential signaling of the GnRH receptor in pituitary gonadotrope cell lines and prostate cancer cell lines. Molecular and Cellular Endocrinology. 369: 107-18. PMID 23380421 DOI: 10.1016/J.Mce.2013.01.010 |
0.389 |
|
| 2013 |
Millholland MG, Mishra S, Dupont CD, Love MS, Patel B, Shilling D, Kazanietz MG, Foskett JK, Hunter CA, Sinnis P, Greenbaum DC. A host GPCR signaling network required for the cytolysis of infected cells facilitates release of apicomplexan parasites. Cell Host & Microbe. 13: 15-28. PMID 23332153 DOI: 10.1016/J.Chom.2012.12.001 |
0.315 |
|
| 2013 |
Garg R, Lal P, Blando J, Benavides FJ, Feldman MD, Smyth EM, Kazanietz MG. Abstract LB-154: COX-2 as a mediator of oncogenic PKCε in prostate cancer. Cancer Research. 73. DOI: 10.1158/1538-7445.Am2013-Lb-154 |
0.408 |
|
| 2013 |
Abera M, Sordella R, Kazanietz M. Abstract 5261: PKC alpha is implicated in epithelial to mesenchymal transition and erlotinib resistance in non-small cell lung carcinoma cells. Cancer Research. 73: 5261-5261. DOI: 10.1158/1538-7445.Am2013-5261 |
0.768 |
|
| 2012 |
Barrio-Real L, Kazanietz MG. Rho GEFs and cancer: linking gene expression and metastatic dissemination. Science Signaling. 5: pe43. PMID 23033535 DOI: 10.1126/Scisignal.2003543 |
0.423 |
|
| 2012 |
Garg R, Blando J, Perez CJ, Wang H, Benavides FJ, Kazanietz MG. Activation of nuclear factor κB (NF-κB) in prostate cancer is mediated by protein kinase C epsilon (PKCepsilon). The Journal of Biological Chemistry. 287: 37570-82. PMID 22955280 DOI: 10.1074/Jbc.M112.398925 |
0.585 |
|
| 2012 |
Riccomagno MM, Hurtado A, Wang H, Macopson JG, Griner EM, Betz A, Brose N, Kazanietz MG, Kolodkin AL. The RacGAP β2-Chimaerin selectively mediates axonal pruning in the hippocampus. Cell. 149: 1594-606. PMID 22726444 DOI: 10.1016/J.Cell.2012.05.018 |
0.434 |
|
| 2012 |
Caino MC, Lopez-Haber C, Kissil JL, Kazanietz MG. Non-small cell lung carcinoma cell motility, rac activation and metastatic dissemination are mediated by protein kinase C epsilon. Plos One. 7: e31714. PMID 22384062 DOI: 10.1371/Journal.Pone.0031714 |
0.489 |
|
| 2012 |
Urtreger AJ, Kazanietz MG, Bal de Kier Joffé ED. Contribution of individual PKC isoforms to breast cancer progression. Iubmb Life. 64: 18-26. PMID 22095874 DOI: 10.1002/Iub.574 |
0.467 |
|
| 2012 |
Caino MC, Lopez-Haber C, Kim J, Mochly-Rosen D, Kazanietz MG. Proteins kinase Cε is required for non-small cell lung carcinoma growth and regulates the expression of apoptotic genes Oncogene. 31: 2593-2600. PMID 21996750 DOI: 10.1038/Onc.2011.428 |
0.457 |
|
| 2012 |
Wertheimer E, Gutierrez-Uzquiza A, Rosemblit C, Lopez-Haber C, Sosa MS, Kazanietz MG. Rac signaling in breast cancer: a tale of GEFs and GAPs. Cellular Signalling. 24: 353-62. PMID 21893191 DOI: 10.1016/J.Cellsig.2011.08.011 |
0.466 |
|
| 2012 |
Garg R, Blando J, Perez CJ, Benavides F, Kazanietz MG. Abstract 534: Protein kinase c ≤ cooperates with Pten deficiency in prostate cancer progression Cancer Research. 72: 534-534. DOI: 10.1158/1538-7445.Am2012-534 |
0.423 |
|
| 2011 |
Wang H, Xiao L, Kazanietz MG. p23/Tmp21 associates with protein kinase Cdelta (PKCdelta) and modulates its apoptotic function. The Journal of Biological Chemistry. 286: 15821-31. PMID 21454541 DOI: 10.1074/Jbc.M111.227991 |
0.609 |
|
| 2011 |
Kazanietz MG, Lemmon MA. Protein kinase C regulation: C1 meets C-tail. Structure (London, England : 1993). 19: 144-6. PMID 21300283 DOI: 10.1016/J.Str.2011.01.004 |
0.429 |
|
| 2011 |
Caino MC, von Burstin VA, Lopez-Haber C, Kazanietz MG. Differential regulation of gene expression by protein kinase C isozymes as determined by genome-wide expression analysis. The Journal of Biological Chemistry. 286: 11254-64. PMID 21252239 DOI: 10.1074/Jbc.M110.194332 |
0.449 |
|
| 2011 |
Benavides F, Blando J, Perez CJ, Garg R, Conti CJ, DiGiovanni J, Kazanietz MG. Transgenic overexpression of PKCε in the mouse prostate induces preneoplastic lesions Cell Cycle. 10: 268-277. PMID 21224724 DOI: 10.4161/Cc.10.2.14469 |
0.376 |
|
| 2011 |
Wang H, Xiao L, Kazanietz MG. Abstract 194: The Golgi/ER protein p23/Tmp21 regulates PKCΔ-mediated apoptosis in prostate cancer cells Cancer Research. 71: 194-194. DOI: 10.1158/1538-7445.Am2011-194 |
0.611 |
|
| 2011 |
Garg R, Benavides F, Blando J, Wang H, Caino MC, Kazanietz MG. Abstract 1031: Protein kinase c ∈ regulates tumor necrosis factor-α induced nuclear factor-κB signaling in prostate cancer Cancer Research. 71: 1031-1031. DOI: 10.1158/1538-7445.Am2011-1031 |
0.602 |
|
| 2010 |
Sosa MS, Lopez-Haber C, Yang C, Wang H, Lemmon MA, Busillo JM, Luo J, Benovic JL, Klein-Szanto A, Yagi H, Gutkind JS, Parsons RE, Kazanietz MG. Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer. Molecular Cell. 40: 877-92. PMID 21172654 DOI: 10.1016/J.Molcel.2010.11.029 |
0.581 |
|
| 2010 |
Meshki J, Caino MC, von Burstin VA, Griner E, Kazanietz MG. Regulation of prostate cancer cell survival by protein kinase Cepsilon involves bad phosphorylation and modulation of the TNFalpha/JNK pathway. The Journal of Biological Chemistry. 285: 26033-40. PMID 20566643 DOI: 10.1074/Jbc.M110.128371 |
0.499 |
|
| 2010 |
von Burstin VA, Xiao L, Kazanietz MG. Bryostatin 1 inhibits phorbol ester-induced apoptosis in prostate cancer cells by differentially modulating protein kinase C (PKC) delta translocation and preventing PKCdelta-mediated release of tumor necrosis factor-alpha. Molecular Pharmacology. 78: 325-32. PMID 20516369 DOI: 10.1124/Mol.110.064741 |
0.478 |
|
| 2010 |
Griner EM, Caino MC, Sosa MS, Colón-González F, Chalmers MJ, Mischak H, Kazanietz MG. A novel cross-talk in diacylglycerol signaling: the Rac-GAP beta2-chimaerin is negatively regulated by protein kinase Cdelta-mediated phosphorylation. The Journal of Biological Chemistry. 285: 16931-41. PMID 20335173 DOI: 10.1074/Jbc.M109.099036 |
0.784 |
|
| 2010 |
Wang H, Kazanietz MG. p23/Tmp21 differentially targets the Rac-GAP beta2-chimaerin and protein kinase C via their C1 domains. Molecular Biology of the Cell. 21: 1398-408. PMID 20164256 DOI: 10.1091/Mbc.E09-08-0735 |
0.573 |
|
| 2010 |
Chinchilla P, Xiao L, Kazanietz MG, Riobo NA. Hedgehog proteins activate pro-angiogenic responses in endothelial cells through non-canonical signaling pathways. Cell Cycle (Georgetown, Tex.). 9: 570-79. PMID 20081366 DOI: 10.4161/Cc.9.3.10591 |
0.39 |
|
| 2010 |
Mauro LV, Grossoni VC, Urtreger AJ, Yang C, Colombo LL, Morandi A, Pallotta MG, Kazanietz MG, Bal de Kier Joffé ED, Puricelli LL. PKC Delta (PKCdelta) promotes tumoral progression of human ductal pancreatic cancer. Pancreas. 39: e31-41. PMID 19924022 DOI: 10.1097/Mpa.0B013E3181Bce796 |
0.409 |
|
| 2010 |
Notcovich C, Diez F, Tubio MR, Baldi A, Kazanietz MG, Davio C, Shayo C. Histamine acting on H1 receptor promotes inhibition of proliferation via PLC, RAC, and JNK-dependent pathways. Experimental Cell Research. 316: 401-11. PMID 19913013 DOI: 10.1016/J.Yexcr.2009.11.002 |
0.439 |
|
| 2010 |
Caino MC, Haber CCL, Kim J, Kazanietz MG. Abstract 1255: Protein kinase C epsilon (PKCε) as a target for lung cancer treatment: Essential role of PKCε in tumor growth and metastatic dissemination of non-small cell lung cancer (NSCLC) cells Cancer Research. 70: 1255-1255. DOI: 10.1158/1538-7445.Am10-1255 |
0.455 |
|
| 2009 |
Xiao L, Eto M, Kazanietz MG. ROCK mediates phorbol ester-induced apoptosis in prostate cancer cells via p21Cip1 up-regulation and JNK. The Journal of Biological Chemistry. 284: 29365-75. PMID 19667069 DOI: 10.1074/Jbc.M109.007971 |
0.435 |
|
| 2009 |
Sosa MS, Lewin NE, Choi SH, Blumberg PM, Kazanietz MG. Biochemical characterization of hyperactive beta2-chimaerin mutants revealed an enhanced exposure of C1 and Rac-GAP domains. Biochemistry. 48: 8171-8. PMID 19618918 DOI: 10.1021/Bi9010623 |
0.388 |
|
| 2009 |
Caino MC, Meshki J, Kazanietz MG. Hallmarks for senescence in carcinogenesis: novel signaling players. Apoptosis : An International Journal On Programmed Cell Death. 14: 392-408. PMID 19169823 DOI: 10.1007/S10495-009-0316-Z |
0.5 |
|
| 2009 |
Grossoni VC, Todaro LB, Kazanietz MG, de Kier Joffé ED, Urtreger AJ. Opposite effects of protein kinase C beta1 (PKCbeta1) and PKCepsilon in the metastatic potential of a breast cancer murine model. Breast Cancer Research and Treatment. 118: 469-80. PMID 19132529 DOI: 10.1007/S10549-008-0299-4 |
0.471 |
|
| 2009 |
Xiao L, Gonzalez-Guerrico A, Kazanietz MG. PKC-mediated secretion of death factors in LNCaP prostate cancer cells is regulated by androgens. Molecular Carcinogenesis. 48: 187-95. PMID 18756441 DOI: 10.1002/Mc.20476 |
0.431 |
|
| 2008 |
Colón-González F, Leskow FC, Kazanietz MG. Identification of an autoinhibitory mechanism that restricts C1 domain-mediated activation of the Rac-GAP alpha2-chimaerin. The Journal of Biological Chemistry. 283: 35247-57. PMID 18826946 DOI: 10.1074/Jbc.M806264200 |
0.758 |
|
| 2008 |
Xiao L, Caino MC, von Burstin VA, Oliva JL, Kazanietz MG. Phorbol ester-induced apoptosis and senescence in cancer cell models. Methods in Enzymology. 446: 123-39. PMID 18603119 DOI: 10.1016/S0076-6879(08)01607-8 |
0.497 |
|
| 2008 |
Oliva JL, Caino MC, Senderowicz AM, Kazanietz MG. S-Phase-specific activation of PKC alpha induces senescence in non-small cell lung cancer cells. The Journal of Biological Chemistry. 283: 5466-76. PMID 18162471 DOI: 10.1074/Jbc.M707576200 |
0.441 |
|
| 2008 |
Yang C, Klein EA, Assoian RK, Kazanietz MG. Heregulin beta1 promotes breast cancer cell proliferation through Rac/ERK-dependent induction of cyclin D1 and p21Cip1. The Biochemical Journal. 410: 167-75. PMID 17941827 DOI: 10.1042/Bj20070781 |
0.497 |
|
| 2007 |
Friedland JC, Lakins JN, Kazanietz MG, Chernoff J, Boettiger D, Weaver VM. alpha6beta4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-kappaB-dependent resistance to apoptosis in 3D mammary acini. Journal of Cell Science. 120: 3700-12. PMID 17911169 DOI: 10.1242/Jcs.03484 |
0.369 |
|
| 2007 |
Grossoni VC, Falbo KB, Mauro LV, Krasnapolski MA, Kazanietz MG, Bal De Kier Joffé ED, Urtreger AJ. Protein kinase C delta inhibits the production of proteolytic enzymes in murine mammary cells. Clinical & Experimental Metastasis. 24: 513-20. PMID 17653823 DOI: 10.1007/S10585-007-9088-4 |
0.486 |
|
| 2007 |
Klein EA, Yang C, Kazanietz MG, Assoian RK. NFkappaB-independent signaling to the cyclin D1 gene by Rac. Cell Cycle (Georgetown, Tex.). 6: 1115-21. PMID 17426454 DOI: 10.4161/Cc.6.9.4147 |
0.318 |
|
| 2007 |
Griner EM, Kazanietz MG. Protein kinase C and other diacylglycerol effectors in cancer. Nature Reviews. Cancer. 7: 281-94. PMID 17384583 DOI: 10.1038/Nrc2110 |
0.52 |
|
| 2007 |
Yang C, Kazanietz MG. Chimaerins: GAPs that bridge diacylglycerol signalling and the small G-protein Rac. The Biochemical Journal. 403: 1-12. PMID 17346241 DOI: 10.1042/Bj20061750 |
0.481 |
|
| 2007 |
Grossoni VC, Falbo KB, Kazanietz MG, de Kier Joffé ED, Urtreger AJ. Protein kinase C delta enhances proliferation and survival of murine mammary cells. Molecular Carcinogenesis. 46: 381-90. PMID 17219421 DOI: 10.1002/Mc.20287 |
0.544 |
|
| 2007 |
Caino MC, Oliva JL, Jiang H, Penning TM, Kazanietz MG. Benzo[a]pyrene-7,8-dihydrodiol promotes checkpoint activation and G2/M arrest in human bronchoalveolar carcinoma H358 cells. Molecular Pharmacology. 71: 744-50. PMID 17114299 DOI: 10.1124/Mol.106.032078 |
0.374 |
|
| 2006 |
Gavrielides MV, Gonzalez-Guerrico AM, Riobo NA, Kazanietz MG. Androgens regulate protein kinase Cdelta transcription and modulate its apoptotic function in prostate cancer cells. Cancer Research. 66: 11792-801. PMID 17178875 DOI: 10.1158/0008-5472.Can-06-1139 |
0.462 |
|
| 2006 |
Wang H, Kazanietz MG. The lipid second messenger diacylglycerol as a negative regulator of Rac signalling. Biochemical Society Transactions. 34: 855-7. PMID 17052214 DOI: 10.1042/Bst0340855 |
0.619 |
|
| 2006 |
Walker JL, Castagnino P, Chung BM, Kazanietz MG, Assoian RK. Post-transcriptional destabilization of p21cip1 by protein kinase C in fibroblasts. The Journal of Biological Chemistry. 281: 38127-32. PMID 17043352 DOI: 10.1074/Jbc.M609622200 |
0.442 |
|
| 2006 |
Colón-González F, Kazanietz MG. C1 domains exposed: from diacylglycerol binding to protein-protein interactions. Biochimica Et Biophysica Acta. 1761: 827-37. PMID 16861033 DOI: 10.1016/J.Bbalip.2006.05.001 |
0.755 |
|
| 2006 |
Wang H, Yang C, Leskow FC, Sun J, Canagarajah B, Hurley JH, Kazanietz MG. Phospholipase Cgamma/diacylglycerol-dependent activation of beta2-chimaerin restricts EGF-induced Rac signaling. The Embo Journal. 25: 2062-74. PMID 16628218 DOI: 10.1038/Sj.Emboj.7601098 |
0.547 |
|
| 2006 |
Leskow FC, Holloway BA, Wang H, Mullins MC, Kazanietz MG. The zebrafish homologue of mammalian chimerin Rac-GAPs is implicated in epiboly progression during development. Proceedings of the National Academy of Sciences of the United States of America. 103: 5373-8. PMID 16569702 DOI: 10.1073/Pnas.0508585103 |
0.543 |
|
| 2006 |
Yang C, Liu Y, Lemmon MA, Kazanietz MG. Essential role for Rac in heregulin beta1 mitogenic signaling: a mechanism that involves epidermal growth factor receptor and is independent of ErbB4. Molecular and Cellular Biology. 26: 831-42. PMID 16428439 DOI: 10.1128/Mcb.26.3.831-842.2006 |
0.497 |
|
| 2006 |
Siliceo M, García-Bernal D, Carrasco S, Díaz-Flores E, Coluccio Leskow F, Leskow FC, Teixidó J, Kazanietz MG, Mérida I. Beta2-chimaerin provides a diacylglycerol-dependent mechanism for regulation of adhesion and chemotaxis of T cells. Journal of Cell Science. 119: 141-52. PMID 16352660 DOI: 10.1242/Jcs.02722 |
0.42 |
|
| 2005 |
Oliva JL, Griner EM, Kazanietz MG. PKC isozymes and diacylglycerol-regulated proteins as effectors of growth factor receptors. Growth Factors (Chur, Switzerland). 23: 245-52. PMID 16338787 DOI: 10.1080/08977190500366043 |
0.438 |
|
| 2005 |
Gonzalez-Guerrico AM, Meshki J, Xiao L, Benavides F, Conti CJ, Kazanietz MG. Molecular mechanisms of protein kinase C-induced apoptosis in prostate cancer cells. Journal of Biochemistry and Molecular Biology. 38: 639-45. PMID 16336777 DOI: 10.5483/Bmbrep.2005.38.6.639 |
0.505 |
|
| 2005 |
Kazanietz MG. Targeting protein kinase C and "non-kinase" phorbol ester receptors: emerging concepts and therapeutic implications. Biochimica Et Biophysica Acta. 1754: 296-304. PMID 16202672 DOI: 10.1016/J.Bbapap.2005.07.034 |
0.507 |
|
| 2005 |
Gonzalez-Guerrico AM, Kazanietz MG. Phorbol ester-induced apoptosis in prostate cancer cells via autocrine activation of the extrinsic apoptotic cascade: a key role for protein kinase C delta. The Journal of Biological Chemistry. 280: 38982-91. PMID 16183650 DOI: 10.1074/Jbc.M506767200 |
0.462 |
|
| 2005 |
Nakagawa M, Oliva JL, Kothapalli D, Fournier A, Assoian RK, Kazanietz MG. Phorbol ester-induced G1 phase arrest selectively mediated by protein kinase Cdelta-dependent induction of p21. The Journal of Biological Chemistry. 280: 33926-34. PMID 16055435 DOI: 10.1074/Jbc.M505748200 |
0.464 |
|
| 2005 |
Santiago-Walker AE, Fikaris AJ, Kao GD, Brown EJ, Kazanietz MG, Meinkoth JL. Protein kinase C δ stimulates apoptosis by initiating G1 phase cell cycle progression and S phase arrest Journal of Biological Chemistry. 280: 32107-32114. PMID 16051606 DOI: 10.1074/Jbc.M504432200 |
0.415 |
|
| 2005 |
Yang C, Liu Y, Leskow FC, Weaver VM, Kazanietz MG. Rac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerin. The Journal of Biological Chemistry. 280: 24363-70. PMID 15863513 DOI: 10.1074/Jbc.M411629200 |
0.494 |
|
| 2005 |
Urtreger AJ, Grossoni VC, Falbo KB, Kazanietz MG, Bal de Kier Joffé ED. Atypical protein kinase C-zeta modulates clonogenicity, motility, and secretion of proteolytic enzymes in murine mammary cells. Molecular Carcinogenesis. 42: 29-39. PMID 15546134 DOI: 10.1002/Mc.20066 |
0.497 |
|
| 2004 |
Canagarajah B, Leskow FC, Ho JY, Mischak H, Saidi LF, Kazanietz MG, Hurley JH. Structural mechanism for lipid activation of the Rac-specific GAP, beta2-chimaerin. Cell. 119: 407-18. PMID 15507211 DOI: 10.1016/J.Cell.2004.10.012 |
0.393 |
|
| 2004 |
Gavrielides MV, Frijhoff AF, Conti CJ, Kazanietz MG. Protein kinase C and prostate carcinogenesis: targeting the cell cycle and apoptotic mechanisms. Current Drug Targets. 5: 431-43. PMID 15216909 DOI: 10.2174/1389450043345380 |
0.427 |
|
| 2004 |
Frey MR, Clark JA, Bateman NW, Kazanietz MG, Black AR, Black JD. Cell cycle- and protein kinase C-specific effects of resiniferatoxin and resiniferonol 9,13,14-ortho-phenylacetate in intestinal epithelial cells. Biochemical Pharmacology. 67: 1873-86. PMID 15130764 DOI: 10.1016/J.Bcp.2004.02.006 |
0.453 |
|
| 2003 |
Yang C, Kazanietz MG. Divergence and complexities in DAG signaling: looking beyond PKC. Trends in Pharmacological Sciences. 24: 602-8. PMID 14607084 DOI: 10.1016/J.Tips.2003.09.003 |
0.471 |
|
| 2003 |
Nakagawa S, Fujii T, Yokoyama G, Kazanietz MG, Yamana H, Shirouzu K. Cell growth inhibition by all-trans retinoic acid in SKBR-3 breast cancer cells: involvement of protein kinase Calpha and extracellular signal-regulated kinase mitogen-activated protein kinase. Molecular Carcinogenesis. 38: 106-16. PMID 14587095 DOI: 10.1002/Mc.10150 |
0.525 |
|
| 2003 |
Caloca MJ, Wang H, Kazanietz MG. Characterization of the Rac-GAP (Rac-GTPase-activating protein) activity of beta2-chimaerin, a 'non-protein kinase C' phorbol ester receptor. The Biochemical Journal. 375: 313-21. PMID 12877655 DOI: 10.1042/Bj20030727 |
0.598 |
|
| 2003 |
Kazanietz MG, Lorenzo PS. Phorbol esters as probes for the study of protein kinase C function. Methods in Molecular Biology (Clifton, N.J.). 233: 423-39. PMID 12840526 DOI: 10.1385/1-59259-397-6:423 |
0.418 |
|
| 2003 |
Kazanietz MG. Pharmacological probes for protein kinase C: an introduction. Methods in Molecular Biology (Clifton, N.J.). 233: 389-95. PMID 12840524 DOI: 10.1385/1-59259-397-6:389 |
0.426 |
|
| 2003 |
Tanaka Y, Gavrielides MV, Mitsuuchi Y, Fujii T, Kazanietz MG. Protein kinase C promotes apoptosis in LNCaP prostate cancer cells through activation of p38 MAPK and inhibition of the Akt survival pathway. The Journal of Biological Chemistry. 278: 33753-62. PMID 12824193 DOI: 10.1074/Jbc.M303313200 |
0.489 |
|
| 2003 |
Li Y, Gonzalez MI, Meinkoth JL, Field J, Kazanietz MG, Tennekoon GI. Lysophosphatidic acid promotes survival and differentiation of rat Schwann cells. The Journal of Biological Chemistry. 278: 9585-91. PMID 12524451 DOI: 10.1074/Jbc.M213244200 |
0.466 |
|
| 2003 |
Kazanietz MG. DAG signaling taught us a lesson: what diverges can converge Blood. 102: 1152-1152. DOI: 10.1182/Blood-2003-06-1938 |
0.334 |
|
| 2002 |
Roaten JB, Kazanietz MG, Caloca MJ, Bertics PJ, Lothstein L, Parrill AL, Israel M, Sweatman TW. Interaction of the novel anthracycline antitumor agent N-benzyladriamycin-14-valerate with the C1-regulatory domain of protein kinase C: structural requirements, isoform specificity, and correlation with drug cytotoxicity. Molecular Cancer Therapeutics. 1: 483-92. PMID 12479266 |
0.319 |
|
| 2002 |
Yu D, Kazanietz MG, Harvey RG, Penning TM. Polycyclic aromatic hydrocarbon o-quinones inhibit the activity of the catalytic fragment of protein kinase C. Biochemistry. 41: 11888-94. PMID 12269833 DOI: 10.1021/Bi020270P |
0.42 |
|
| 2002 |
Kazanietz MG. Novel "nonkinase" phorbol ester receptors: the C1 domain connection. Molecular Pharmacology. 61: 759-67. PMID 11901214 DOI: 10.1124/Mol.61.4.759 |
0.458 |
|
| 2002 |
Wang H, Kazanietz MG. Chimaerins, novel non-protein kinase C phorbol ester receptors, associate with Tmp21-I (p23): evidence for a novel anchoring mechanism involving the chimaerin C1 domain. The Journal of Biological Chemistry. 277: 4541-50. PMID 11689559 DOI: 10.1074/Jbc.M107150200 |
0.618 |
|
| 2002 |
Garcia-Bermejo ML, Leskow FC, Fujii T, Wang Q, Blumberg PM, Ohba M, Kuroki T, Han KC, Lee J, Marquez VE, Kazanietz MG. Diacylglycerol (DAG)-lactones, a new class of protein kinase C (PKC) agonists, induce apoptosis in LNCaP prostate cancer cells by selective activation of PKCalpha. The Journal of Biological Chemistry. 277: 645-55. PMID 11584014 DOI: 10.1074/Jbc.M107639200 |
0.469 |
|
| 2001 |
Barry OP, Kazanietz MG. Protein kinase C isozymes, novel phorbol ester receptors and cancer chemotherapy. Current Pharmaceutical Design. 7: 1725-1744. PMID 11562308 DOI: 10.2174/1381612013397041 |
0.487 |
|
| 2001 |
Qiao L, Zhao LY, Rong SB, Wu XW, Wang S, Fujii T, Kazanietz MG, Rauser L, Savage J, Roth BL, Flippen-Anderson J, Kozikowski AP. Rational design, synthesis, and biological evaluation of rigid pyrrolidone analogues as potential inhibitors of prostate cancer cell growth. Bioorganic & Medicinal Chemistry Letters. 11: 955-9. PMID 11327599 DOI: 10.1016/S0960-894X(01)00097-X |
0.478 |
|
| 2001 |
Roaten JB, Kazanietz MG, Sweatman TW, Lothstein L, Israel M, Parrill AL. Molecular models of N-benzyladriamycin-14-valerate (AD 198) in complex with the phorbol ester-binding C1b domain of protein kinase C-delta. Journal of Medicinal Chemistry. 44: 1028-34. PMID 11297449 DOI: 10.1021/Jm000289V |
0.385 |
|
| 2001 |
Caloca MJ, Wang H, Delemos A, Wang S, Kazanietz MG. Phorbol esters and related analogs regulate the subcellular localization of beta 2-chimaerin, a non-protein kinase C phorbol ester receptor. The Journal of Biological Chemistry. 276: 18303-12. PMID 11278894 DOI: 10.1074/Jbc.M011368200 |
0.558 |
|
| 2000 |
Fernandez N, Caloca MA, Prendergast GV, Meinkoth JL, Kazanietz MG. Atypical Protein Kinase C-ζ Stimulates Thyrotropin-Independent Proliferation in Rat Thyroid Cells1. Endocrinology. 141: 146-152. PMID 28200778 DOI: 10.1210/Endo.141.1.7278 |
0.45 |
|
| 2000 |
Aroca P, Santos E, Kazanietz MG. Recombinant C1b domain of PKCδ triggers meiotic maturation upon microinjection in Xenopus laevis oocytes Febs Letters. 483: 27-32. PMID 11033350 DOI: 10.1016/S0014-5793(00)02075-5 |
0.376 |
|
| 2000 |
Kazanietz MG, Caloca MJ, Eroles P, Fujii T, García-Bermejo ML, Reilly M, Wang H. Pharmacology of the receptors for the phorbol ester tumor promoters: multiple receptors with different biochemical properties. Biochemical Pharmacology. 60: 1417-24. PMID 11020443 DOI: 10.1016/S0006-2952(00)00470-6 |
0.58 |
|
| 2000 |
Kazanietz MG. Eyes wide shut: protein kinase C isozymes are not the only receptors for the phorbol ester tumor promoters. Molecular Carcinogenesis. 28: 5-11. PMID 10820483 DOI: 10.1002/(Sici)1098-2744(200005)28:1<5::Aid-Mc2>3.0.Co;2-G |
0.455 |
|
| 2000 |
Galán A, GarcÃa-Bermejo ML, Troyano A, Vilaboa NE, de Blas E, Kazanietz MG, Aller P. Stimulation of p38 mitogen-activated protein kinase is an early regulatory event for the cadmium-induced apoptosis in human promonocytic cells. The Journal of Biological Chemistry. 275: 11418-24. PMID 10753958 DOI: 10.1074/Jbc.275.15.11418 |
0.422 |
|
| 2000 |
Fujii T, Garcı́a-Bermejo ML, Bernabó JL, Caamaño J, Ohba M, Kuroki T, Li L, Yuspa SH, Kazanietz MG. Involvement of Protein Kinase C δ (PKCδ) in Phorbol Ester-induced Apoptosis in LNCaP Prostate Cancer Cells LACK OF PROTEOLYTIC CLEAVAGE OF PKCδ Journal of Biological Chemistry. 275: 7574-7582. PMID 10713064 DOI: 10.1074/Jbc.275.11.7574 |
0.463 |
|
| 1999 |
Caloca MJ, Garcia-Bermejo ML, Blumberg PM, Lewin NE, Kremmer E, Mischak H, Wang S, Nacro K, Bienfait B, Marquez VE, Kazanietz MG. beta2-chimaerin is a novel target for diacylglycerol: binding properties and changes in subcellular localization mediated by ligand binding to its C1 domain. Proceedings of the National Academy of Sciences of the United States of America. 96: 11854-9. PMID 10518540 DOI: 10.1073/Pnas.96.21.11854 |
0.408 |
|
| 1999 |
Ron D, Kazanietz MG. New insights into the regulation of protein kinase C and novel phorbol ester receptors. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 13: 1658-76. PMID 10506570 DOI: 10.1096/Fasebj.13.13.1658 |
0.493 |
|
| 1999 |
Gómez ML, Ochatt CM, Kazanietz MG, Torres HN, Téllez-Iñón MT. Biochemical and immunological studies of protein kinase C from Trypanosoma cruzi. International Journal For Parasitology. 29: 981-9. PMID 10501608 DOI: 10.1016/S0020-7519(99)00041-7 |
0.441 |
|
| 1999 |
Barry OP, Kazanietz MG, Praticò D, FitzGerald GA. Arachidonic acid in platelet microparticles up-regulates cyclooxygenase-2-dependent prostaglandin formation via a protein kinase C/mitogen-activated protein kinase-dependent pathway. The Journal of Biological Chemistry. 274: 7545-56. PMID 10066822 DOI: 10.1074/Jbc.274.11.7545 |
0.46 |
|
| 1997 |
Caloca MJ, Fernandez N, Lewin NE, Ching D, Modali R, Blumberg PM, Kazanietz MG. Beta2-chimaerin is a high affinity receptor for the phorbol ester tumor promoters. The Journal of Biological Chemistry. 272: 26488-96. PMID 9334226 DOI: 10.1074/Jbc.272.42.26488 |
0.368 |
|
| 1996 |
Jideama NM, Noland TA, Raynor RL, Blobe GC, Fabbro D, Kazanietz MG, Blumberg PM, Hannun YA, Kuo JF. Phosphorylation specificities of protein kinase C isozymes for bovine cardiac troponin I and troponin T and sites within these proteins and regulation of myofilament properties. The Journal of Biological Chemistry. 271: 23277-83. PMID 8798526 DOI: 10.1074/Jbc.271.38.23277 |
0.39 |
|
| 1996 |
Wang S, Kazanietz MG, Blumberg PM, Marquez VE, Milne GW. Molecular modeling and site-directed mutagenesis studies of a phorbol ester-binding site in protein kinase C. Journal of Medicinal Chemistry. 39: 2541-53. PMID 8691452 DOI: 10.1021/Jm950403N |
0.381 |
|
| 1995 |
Kazanietz MG, Barchi JJ, Omichinski JG, Blumberg PM. Low affinity binding of phorbol esters to protein kinase C and its recombinant cysteine-rich region in the absence of phospholipids Journal of Biological Chemistry. 270: 14679-14684. PMID 7782331 DOI: 10.1074/Jbc.270.24.14679 |
0.438 |
|
| 1995 |
Zhang G, Kazanietz MG, Blumberg PM, Hurley JH. Crystal structure of the cys2 activator-binding domain of protein kinase C delta in complex with phorbol ester. Cell. 81: 917-24. PMID 7781068 DOI: 10.1016/0092-8674(95)90011-X |
0.435 |
|
| 1995 |
Kazanietz MG, Wang S, Milne GW, Lewin NE, Liu HL, Blumberg PM. Residues in the second cysteine-rich region of protein kinase C delta relevant to phorbol ester binding as revealed by site-directed mutagenesis. The Journal of Biological Chemistry. 270: 21852-9. PMID 7665608 DOI: 10.1074/Jbc.270.37.21852 |
0.386 |
|
| 1995 |
Kazanietz MG, Lewin NE, Bruns JD, Blumberg PM. Characterization of the cysteine-rich region of the Caenorhabditis elegans protein Unc-13 as a high affinity phorbol ester receptor. Analysis of ligand-binding interactions, lipid cofactor requirements, and inhibitor sensitivity. The Journal of Biological Chemistry. 270: 10777-83. PMID 7537738 DOI: 10.1074/Jbc.270.18.10777 |
0.416 |
|
| 1995 |
Winkler JD, Hong B, Bahador A, Kazanietz MG, Blumberg PM. Inside-outside stereoisomerism. VII. Methodology for the Synthesis of 3-Oxygenated Ingenanes. The First Ingenol Analogs with High Affinity for Protein Kinase C The Journal of Organic Chemistry. 60: 1381-1390. DOI: 10.1021/Jo00110A048 |
0.388 |
|
| 1994 |
Lee J, Marquez VE, Blumberg PM, Krausz KW, Kazanietz MG. Conformationally constrained analogues of diacylglycerol (DAG)--II. Differential interaction of delta-lactones and gamma-lactones with protein kinase C (PK-C). Bioorganic & Medicinal Chemistry. 1: 119-23. PMID 8081841 DOI: 10.1016/S0968-0896(00)82109-4 |
0.311 |
|
| 1994 |
Razin E, Szallasi Z, Kazanietz MG, Blumberg PM, Rivera J. Protein kinases C-beta and C-epsilon link the mast cell high-affinity receptor for IgE to the expression of c-fos and c-jun. Proceedings of the National Academy of Sciences of the United States of America. 91: 7722-6. PMID 8052650 DOI: 10.1073/Pnas.91.16.7722 |
0.422 |
|
| 1993 |
Winkler JD, Hong BC, Bahador A, Kazanietz MG, Blumberg PM. Synthesis of ingenol analogs wth affinity for protein kinase C Bioorganic and Medicinal Chemistry Letters. 3: 577-580. DOI: 10.1016/S0960-894X(01)81232-4 |
0.404 |
|
| 1993 |
Lee J, Marquez VE, Lewin NE, Kazanietz MG, Bahador A, Blumberg PM. Conformationally constrained analogues of diacylglycerol (DAG). 3. Interaction of α-alkyl-γ-lactones with protein kinase C (PK-C) Bioorganic & Medicinal Chemistry Letters. 3: 1101-1106. DOI: 10.1016/S0960-894X(00)80295-4 |
0.398 |
|
| 1992 |
Goodnight J, Kazanietz MG, Blumberg PM, Mushinski JF, Mischak H. The cDNA sequence, expression pattern and protein characteristics of mouse protein kinase C-zeta. Gene. 122: 305-11. PMID 1487145 DOI: 10.1016/0378-1119(92)90219-F |
0.367 |
|
| 1992 |
Teng K, Marquez VE, Milne GWA, Barchi JJ, Kazanietz MG, Lewin NE, Blumberg PM, Abushanab E. Conformationally constrained analogs of diacylglycerol. Interaction of .gamma.-lactones with the phorbol ester receptor of protein kinase C Journal of the American Chemical Society. 114: 1059-1070. DOI: 10.1021/Ja00029A039 |
0.423 |
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